Affinage

TIAM2

Rho guanine nucleotide exchange factor TIAM2 · UniProt Q8IVF5

Length
1701 aa
Mass
190.1 kDa
Annotated
2026-06-10
27 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STEF/TIAM2 is a Rac1-selective guanine nucleotide exchange factor that converts upstream receptor and small-GTPase signals into localized Rac1 activation driving actin cytoskeletal remodeling (PMID:10364228). Its catalytic DH domain mediates selective GDP release from Rac1 (not RhoA or Cdc42), with the C-terminal PH domain promoting catalysis and the N-terminal PH/TSS region directing membrane association; loss of this membrane-targeting module blocks Rac1-dependent neurite outgrowth (PMID:10364228, PMID:11707441). TIAM2 operates within defined spatial signaling assemblies: it binds PAR-3 to join the PAR-3/aPKC/PAR-6/Cdc42-GTP polarity complex that couples Cdc42 to Rac1 activation and lamellipodia formation during neuronal polarization (PMID:15723051), and it associates with activated Rap1 through its TSS region downstream of cAMP/Epac signaling (PMID:18047838). Through these inputs TIAM2 supports radial migration of cortical neurons via a Rac1-JNK-MAP1B axis controlling microtubule dynamics (PMID:12912917), growth-cone lamellipodium formation (PMID:14550769), microtubule-induced focal adhesion disassembly during cell migration (PMID:20224579), and maintenance of the perinuclear actin cap at the nuclear envelope where it co-localizes with Nesprin-2G and non-muscle myosin IIB to regulate nuclear mechanics and TAZ-dependent transcription (PMID:29844364). Its activity is bidirectionally tuned by phosphorylation: PKA phosphorylation at Thr-749 is required for cAMP-induced Rac1 activation and neurite outgrowth (PMID:21460187), whereas Rho-kinase phosphorylation at Thr-1662 suppresses Rac1 activation and weakens its interaction with MAP1B (PMID:17320046). TIAM2 also drives Rac1-dependent invasion and epithelial-to-mesenchymal transition in carcinoma cells downstream of EGFR/c-Met receptor tyrosine kinases (PMID:21469146, PMID:24377522, PMID:34731623), and its mRNA is stabilized by NSUN2-catalyzed m5C methylation in a YBX1-dependent manner (PMID:37393317).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1999 High

    Established that TIAM2 is a catalytically active GEF with selectivity for Rac1, defining its core biochemical identity and downstream effector.

    Evidence In vitro GDP dissociation/exchange assays with purified protein, domain analysis, and cell-based ruffling assay; independent cloning as STEF and as a TIAM1 homolog

    PMID:10364228 PMID:10512681

    Open questions at the time
    • Did not resolve how Rac1 selectivity is structurally encoded
    • Upstream activators unknown at this stage
  2. 2001 High

    Mapped functional roles to individual domains, showing membrane targeting (N-terminal PH), catalysis (DH), and catalytic enhancement (C-terminal PH) are separable and that TIAM2 drives neurite outgrowth through Rac1.

    Evidence Deletion mutagenesis, dominant-negative expression with rescue, neurite outgrowth assay in N1E-115 neuroblastoma cells

    PMID:11707441

    Open questions at the time
    • Dominant-negative PHnTSS fragment also inhibits Tiam1, leaving paralog-specific contributions unresolved
    • Membrane lipid/protein determinants of PH targeting not defined
  3. 2003 High

    Demonstrated an in vivo requirement for TIAM2/Tiam1-Rac1 signaling in cortical neuron migration and linked it to a Rac1-JNK-MAP1B microtubule-regulatory axis.

    Evidence In utero electroporation of dominant-negative/shRNA constructs, cortical migration assay, JNK inhibitor and MAP1B phosphorylation analysis

    PMID:12912917

    Open questions at the time
    • Does not separate TIAM2 from Tiam1 contributions in vivo
    • Upstream receptor triggering migratory Rac1 activation not identified
  4. 2003 Medium

    Localized TIAM2 to growth cones and placed it at the convergence of laminin and Cdc42 inputs activating Rac1, with RhoA acting antagonistically.

    Evidence Dominant-negative expression, immunolocalization in primary hippocampal neurons, growth cone morphology assay, epistasis with Cdc42 and RhoA

    PMID:14550769

    Open questions at the time
    • Epistasis relies on dominant-negative constructs without direct binding data for laminin receptor coupling
    • Mechanism of RhoA antagonism not defined here
  5. 2005 High

    Defined the molecular bridge by which Cdc42 activates Rac1, showing direct PAR-3 binding incorporates TIAM2 into the PAR polarity complex to drive lamellipodia and neuronal polarity.

    Evidence Reciprocal co-immunoprecipitation, direct binding assays, dominant-negative/overexpression and Rac1 activation assays in N1E-115 cells and hippocampal neurons

    PMID:15723051

    Open questions at the time
    • Which TIAM2 domain mediates PAR-3 binding not pinpointed
    • How complex assembly is spatially restricted to the axon tip not fully resolved
  6. 2007 High

    Identified Rho-kinase phosphorylation at Thr-1662 as a negative regulatory input that dampens Rac1 activation and disrupts the TIAM2-MAP1B interaction.

    Evidence In vitro kinase assay, site-directed mutagenesis, Rac1 activation assay, Co-IP, neurite outgrowth assay, Y-27632 inhibitor in PC12D cells

    PMID:17320046

    Open questions at the time
    • Structural basis for how Thr-1662 phosphorylation alters activity not determined
    • Physiological stimuli engaging this brake beyond LPA not mapped
  7. 2007 Medium

    Connected TIAM2 to the cAMP/Epac/Rap1 cascade via TSS-region binding to activated Rap1, linking it to Rac1-dependent non-amyloidogenic APP processing.

    Evidence Co-IP of Rap1-STEF, ΔTSS deletion mutant, Rac1 activation and sAPPα secretion assays

    PMID:18047838

    Open questions at the time
    • Single-lab Co-IP without structural mapping of the Rap1-TSS interface
    • Whether Rap1 binding is direct or complex-mediated not established
  8. 2010 High

    Revealed a role in cell migration whereby TIAM2-driven Rac1 activation couples microtubule regrowth to focal adhesion disassembly.

    Evidence siRNA knockdown, Rac1 activation assay, live imaging of FA dynamics, nocodazole washout, migration speed measurement

    PMID:20224579

    Open questions at the time
    • How microtubule contact triggers TIAM2 recruitment/activation not defined
    • Direct microtubule-TIAM2 association not demonstrated
  9. 2011 High

    Defined the distinct PDZ ligand specificity of TIAM2 relative to Tiam1 at the residue level, establishing non-redundant scaffolding interactions.

    Evidence Combinatorial peptide library, peptide binding assays, site-directed mutagenesis, double mutant cycle analysis

    PMID:21192692

    Open questions at the time
    • Endogenous physiological PDZ ligands of TIAM2 not identified
    • Functional consequence of distinct specificity in cells untested
  10. 2011 High

    Identified PKA phosphorylation at Thr-749 as a positive regulatory input required for cAMP-induced, spatially localized Rac1 activation and neurite outgrowth.

    Evidence FRET biosensors, siRNA knockdown, phosphorylation-site mutants, neurite outgrowth and PKA activity reporters in PC12D cells

    PMID:21460187

    Open questions at the time
    • Mechanism by which Thr-749 phosphorylation enhances GEF activity not structurally resolved
    • Interplay with Rho-kinase inhibitory phosphorylation not directly tested
  11. 2018 High

    Uncovered a nuclear-envelope function in which TIAM2 controls perinuclear Rac1 to maintain the actin cap, nuclear mechanics, and TAZ-dependent transcription.

    Evidence siRNA knockdown with active-Rac1 nuclear-envelope targeting rescue, perinuclear FRET biosensor, FRAP, nuclear morphology and TAZ reporter assays; co-localization with Nesprin-2G and NMMIIB

    PMID:29844364

    Open questions at the time
    • How TIAM2 is recruited to the nuclear envelope not defined
    • Whether Nesprin-2G binding is direct not established
  12. 2011 Medium

    Implicated TIAM2 (and a short isoform) in carcinoma progression by promoting Rac1-dependent invasion and epithelial-to-mesenchymal transition.

    Evidence Stable overexpression/siRNA knockdown, proliferation/invasion assays, xenograft models, and EMT marker analysis in hepatocellular and lung cancer cells

    PMID:21469146 PMID:24377522

    Open questions at the time
    • Causal upstream activators of TIAM2 in these tumors not fully defined here
    • Isoform-specific mechanisms not resolved in the carcinoma context
  13. 2019 Medium

    Showed isoform-specific and opposing TIAM2 functions in mouse t-haplotype transmission ratio distortion via Rac1 signaling in sperm.

    Evidence Transgenic mouse approaches, transmission ratio distortion assay, isoform-specific expression analysis

    PMID:30817801

    Open questions at the time
    • Molecular basis for opposing short vs full-length isoform activity unresolved
    • Direct sperm Rac1 substrate/effector readouts limited
  14. 2021 Medium

    Positioned TIAM2 as a non-redundant Rac-GEF for lung adenocarcinoma cell migration downstream of EGFR/c-Met receptor tyrosine kinases controlling distinct ruffle dynamics.

    Evidence siRNA functional screen, Rac1 activity assay, ruffle dynamics imaging, epistasis with EGFR/c-Met/AXL-Gab1-PI3K

    PMID:34731623

    Open questions at the time
    • Direct receptor-to-TIAM2 coupling mechanism not defined
    • Basis for non-redundancy with FARP1/ARHGEF39 unresolved
  15. 2023 Medium

    Identified post-transcriptional control of TIAM2 by NSUN2-mediated m5C mRNA methylation, stabilizing the transcript and supporting cancer EMT and metastasis.

    Evidence m5C-seq, RNA-seq, knockdown/overexpression, mRNA stability and YBX1 dependency assays, xenograft in pancreatic cancer

    PMID:37393317

    Open questions at the time
    • Methylated residues on TIAM2 mRNA not pinpointed
    • Whether m5C control operates in non-cancer contexts unknown
  16. 2023 Medium

    Demonstrated that dually lipidated CaMKIγ couples to compartmentalized STEF-Rac1 signaling at lipid rafts to drive neurite extension, requiring palmitoylation.

    Evidence Lipid raft fractionation, palmitoylation/prenylation mutants, Rac1 activity and neurite outgrowth assays in PC12 cells

    PMID:37601281

    Open questions at the time
    • Whether CaMKIγ directly modifies/binds TIAM2 not established
    • Lipid-raft recruitment determinants of TIAM2 undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for how phosphorylation (Thr-749 activation vs Thr-1662 inhibition) and partner binding (PAR-3, Rap1, Nesprin-2G) toggle TIAM2 catalytic activity, and how distinct spatial pools are coordinated, remains unresolved.
  • No structural model of full-length TIAM2 or its regulatory interfaces in the corpus
  • Direct vs scaffold-mediated nature of several key partner interactions undetermined
  • Mechanism integrating opposing kinase inputs on a single molecule not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005856 cytoskeleton 3 GO:0005886 plasma membrane 3 GO:0005635 nuclear envelope 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4
Partners
CDC42MAP1BMYH10PARD3RAC1RAP1SYNE2
Complex memberships
PAR-3/aPKC/PAR-6/Cdc42 polarity complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 STEF/TIAM2 is a novel guanine nucleotide exchange factor (GEF) that specifically activates Rac1 but not RhoA or Cdc42. In vitro GDP dissociation assays demonstrated selective GDP release from Rac1. The protein contains two pleckstrin homology (PH) domains, a PDZ domain, and a Dbl homology (DH) domain. Expression of a truncated STEF in cultured cells induced membrane ruffling with altered actin localization, indicating in vivo Rac1 activation. In vitro GDP dissociation assay, domain structure analysis, cell-based ruffling assay The Journal of biological chemistry High 10364228
1999 TIAM2 (cloned independently as a TIAM1 homolog) encodes a protein with GDP-GTP exchange activity, confirmed by direct purification and exchange assay. Protein purification, GDP-GTP exchange assay Genomics High 10512681
2001 Domain dissection of STEF revealed that the N-terminal PH domain (PHnTSS) is required for membrane association, the DH domain carries enzymatic GEF activity, and the C-terminal PH domain (PHc) promotes catalytic activity. A dominant-negative PHnTSS fragment inhibited both STEF and Tiam1 function and blocked neurite outgrowth in N1E-115 neuroblastoma cells; this inhibition was rescued by exogenous STEF or Tiam1, demonstrating STEF acts through Rac1 to drive neurite formation. Deletion mutagenesis, dominant-negative expression, neurite outgrowth assay, rescue experiment The Journal of biological chemistry High 11707441
2003 In vivo gene transfer by in utero electroporation showed that STEF/Tiam1 (Rac1 activators) are required for radial migration of cortical neurons. Functional repression of STEF/Tiam1 or Rac1 inhibited neuronal migration and caused loss of the leading process; downstream JNK (activated by Rac1) regulates microtubule dynamics via MAP1B phosphorylation in migrating neurons. In utero electroporation (dominant-negative/shRNA), cortical migration assay, JNK inhibitor treatment, MAP1B phosphorylation assay The EMBO journal High 12912917
2003 STEF and Tiam1 localize within growth cones of primary hippocampal neurons and are essential for formation of growth cone lamellipodia and neurite growth. STEF/Tiam1 mediate extracellular laminin signals and intracellular Cdc42 signals to activate Rac1 in the growth cone; RhoA inhibits the STEF/Tiam1-Rac1 pathway. Dominant-negative expression, immunolocalization in primary neurons, growth cone morphology assay, epistasis with Cdc42 and RhoA Molecular and cellular neurosciences Medium 14550769
2005 PAR-3 directly interacts with STEF/Tiam1 (Rac-specific GEFs) and STEF forms a complex with PAR-3-aPKC-PAR-6-Cdc42-GTP. This complex mediates Cdc42-induced Rac activation and lamellipodia formation in neuroblastoma cells and cultured hippocampal neurons, establishing a Cdc42-PAR-6-PAR-3-STEF-Rac pathway required for neuronal polarity. Disruption of PAR-3-STEF binding inhibited Cdc42-induced lamellipodia but not filopodia. STEF accumulates at the tip of the growing axon co-localizing with PAR-3. Co-immunoprecipitation, direct binding assay, dominant-negative and overexpression in N1E-115 cells and hippocampal neurons, Rac1 activation assay Nature cell biology High 15723051
2007 Rho-kinase phosphorylates STEF at Thr1662 in vitro, reducing STEF-induced Rac1 activation in COS7 cells. LPA-induced phosphorylation of STEF in PC12D cells is suppressed by Y-27632 (Rho-kinase inhibitor). Phosphorylation diminishes STEF interaction with microtubule-associated protein 1B (MAP1B), and a phosphomimetic STEF mutant has weakened ability to enhance NGF-induced neurite outgrowth. In vitro kinase assay, site-directed mutagenesis, Rac1 activation assay, Co-immunoprecipitation, neurite outgrowth assay, pharmacological inhibitor Biochemical and biophysical research communications High 17320046
2007 STEF physically associates with activated Rap1 through its TSS region. Rap1-STEF interaction downstream of the cAMP/Epac/Rap1 cascade activates Rac1, which mediates non-amyloidogenic alpha-cleavage of APP (sAPPα secretion). A deleted TSS domain of STEF fails to activate Rac1 and dramatically decreases sAPPα secretion induced by Epac. Co-immunoprecipitation (Rap1-STEF), deletion mutagenesis (ΔTSS), Rac1 activation assay, sAPPα secretion assay FEBS letters Medium 18047838
2010 STEF/TIAM2 is required for Rac activation during microtubule regrowth (following nocodazole washout), which drives focal adhesion (FA) disassembly. STEF knockdown reduces the rate of multiple FA targeting by microtubules, leading to enlarged FAs and reduced cell migration speed. siRNA knockdown, Rac1 activation assay (FRET/pulldown), live imaging of FA dynamics (fluorescence microscopy), nocodazole washout assay, migration speed measurement EMBO reports High 20224579
2011 The PDZ domains of Tiam1 and Tiam2 have overlapping but distinct ligand specificities determined by non-conserved residues in the S(0) and S(-2) pockets. Site-directed mutagenesis of four non-conserved residues in Tiam1's PDZ domain converted its specificity to that of Tiam2, as confirmed by combinatorial peptide library screening and binding assays with native protein-derived peptides. Combinatorial peptide library, peptide binding assays, site-directed mutagenesis, double mutant cycle analysis Biochemistry High 21192692
2011 PKA phosphorylates STEF at three residues (Thr-749, Ser-782, Ser-1562); phosphorylation at Thr-749 is specifically critical for cAMP/dbcAMP-induced Rac1 activation and neurite outgrowth in PC12D cells. STEF depletion drastically reduces dbcAMP-induced neurite outgrowth. During dbcAMP stimulation, PKA activation at the plasma membrane becomes localized to neurite tips, coinciding with local Rac1 activation via STEF. FRET-based biosensors (Rac1, Cdc42, PIP3), STEF siRNA knockdown, site-directed mutagenesis (phosphorylation-site mutants), neurite outgrowth assay, PKA activity reporter Molecular biology of the cell High 21460187
2011 Expression of TIAM2S (short isoform) in HepG2 hepatocellular carcinoma cells promoted cell growth, invasiveness, and in vivo tumor formation in xenograft mice. TIAM2S expression upregulated N-cadherin and vimentin and caused redistribution of E-cadherin, indicating promotion of epithelial-to-mesenchymal transition (EMT). Stable overexpression, proliferation and invasion assays, xenograft mouse model, Western blot for EMT markers International journal of cancer Medium 21469146
2013 TIAM2 knockdown by siRNA in NSCLC cells suppressed Rac1 activation (assessed by GST pulldown), reduced invasion and motility, upregulated E-cadherin, and downregulated MMP-3, Twist, and Snail, linking TIAM2-mediated Rac1 activation to EMT regulation in lung cancer cells. siRNA knockdown, GST-Rac1 pulldown activation assay, invasion/motility assay, Western blot for EMT markers Asian Pacific journal of cancer prevention Medium 24377522
2018 STEF/TIAM2 localizes at the nuclear envelope, co-localizing with Nesprin-2G and Non-muscle myosin IIB (NMMIIB), where it regulates perinuclear Rac1 activity. STEF depletion reduces apical perinuclear actin cables (rescued by targeting active Rac1 to the nuclear envelope), increases nuclear height, impairs nuclear re-orientation, reduces perinuclear pMLC and myosin-generated tension at the nuclear envelope, decreases nuclear stiffness, and reduces TAZ-regulated gene expression. siRNA knockdown, fluorescence localization (co-localization with Nesprin-2G and NMMIIB), FRET-based perinuclear Rac1 biosensor, active-Rac1 nuclear envelope targeting rescue, FRAP, nuclear morphology assay, TAZ reporter Nature communications High 29844364
2019 Two isoforms of TIAM2 act oppositely in regulating transmission ratio distortion (TRD) by the mouse t-haplotype: the short isoform (Tiam2s), whose expression is strongly increased from the t-allele, enhances t-haplotype transmission (sperm motility-linked), while the full-length isoform (Tiam2l) has the opposite effect. Both isoforms affect Rac1 signaling in sperm. Transgenic mouse approaches, transmission ratio distortion assay, isoform-specific expression analysis PLoS genetics Medium 30817801
2021 TIAM2 is identified as an essential Rac-GEF responsible for Rac1-mediated lung adenocarcinoma cell migration downstream of EGFR and c-Met receptor tyrosine kinases. TIAM2 controls distinctive aspects of ruffle dynamics in a non-redundant manner with FARP1 and ARHGEF39. The AXL-Gab1-PI3K axis confers pro-motility signaling in this context. siRNA knockdown (functional screen), Rac1 activity assay, ruffle dynamics live imaging, epistasis with EGFR/c-Met/AXL-Gab1-PI3K pathway Cell reports Medium 34731623
2023 NSUN2-catalyzed m5C methylation of TIAM2 mRNA stabilizes the transcript in a YBX1-dependent manner. Loss of NSUN2 decreases m5C modification on TIAM2 mRNA, accelerates its decay, reduces TIAM2 expression, and suppresses pancreatic cancer EMT, growth, and metastasis. Rescue experiments confirmed TIAM2 acts downstream of NSUN2. m5C-seq, RNA-seq, lentiviral knockdown/overexpression, mRNA stability assay, YBX1 dependency assay, in vivo xenograft Cell death discovery Medium 37393317
2023 Dually lipidated CaMKIγ (prenylated and palmitoylated) functionally couples to STEF-Rac1 signaling at lipid rafts to drive neurite extension in PC12 cells. Palmitoylation is specifically required for CaMKIγ to activate the compartmentalized STEF-Rac1 pathway; prenylation alone is insufficient for this functional coupling. Lipid raft fractionation, palmitoylation/prenylation mutants, Rac1 activity assay, neurite outgrowth assay in PC12 cells lacking endogenous CaMKIγ Frontiers in cellular neuroscience Medium 37601281

Source papers

Stage 0 corpus · 27 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nature cell biology 313 15723051
2003 The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. The EMBO journal 258 12912917
1999 Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. The Journal of biological chemistry 96 10364228
2010 The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO reports 77 20224579
2001 Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth. The Journal of biological chemistry 76 11707441
2023 NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer. Cell death discovery 48 37393317
2018 STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature communications 48 29844364
2003 Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology. Molecular and cellular neurosciences 46 14550769
2011 Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer. International journal of cancer 44 21469146
1999 Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. Genomics 42 10512681
2007 Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing. FEBS letters 33 18047838
2011 Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains. Biochemistry 32 21192692
2021 FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma. Cell reports 30 34731623
2022 TIAM2 Contributes to Osimertinib Resistance, Cell Motility, and Tumor-Associated Macrophage M2-like Polarization in Lung Adenocarcinoma. International journal of molecular sciences 28 36142328
2011 Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells. Molecular biology of the cell 28 21460187
2019 Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype. PLoS genetics 26 30817801
2007 Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. Biochemical and biophysical research communications 24 17320046
2002 Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain. Mechanisms of development 22 11900975
2013 TIAM2 enhances non-small cell lung cancer cell invasion and motility. Asian Pacific journal of cancer prevention : APJCP 20 24377522
2019 The Fibroblast TIAM2 Promotes Lung Cancer Cell Invasion and Metastasis. Journal of Cancer 15 31205545
2021 The invasive alien red-eared slider turtle, Trachemys scripta, as a carrier of STEF-disease pathogens. Fungal biology 11 35078582
2024 Verbascum ponticum (Stef.) Extract Induces Lung Cancer Apoptosis via Mitochondrial-Dependent Apoptosis Pathway. Life (Basel, Switzerland) 4 39598318
2023 Lipidation states orchestrate CLICK-III/CaMKIγ's stepwise association with Golgi and rafts-enriched membranes and specify its functional coupling to STEF-Rac1-dependent neurite extension. Frontiers in cellular neuroscience 4 37601281
2022 TIAM2 promotes proliferation and invasion of osteosarcoma cells by activating the JAK2/STAT3 signaling pathway. Journal of bone oncology 3 36419799
2026 TIAM2 and ADCY7 polymorphisms and their association with feed efficiency in Huaibei partridge chickens. Poultry science 0 42035529
2026 Biologically Active Compounds and Antioxidant and DNA-Protective Potential of Rhodope Avens (Geum rhodopaeum Stoj.&Stef.) Dry Tinctures. Molecules (Basel, Switzerland) 0 42197197
2024 The analysis on Tiam2 for expression in esophageal carcinoma: A descriptive study. Medicine 0 39093764

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