Affinage

SYCP2

Synaptonemal complex protein 2 · UniProt Q9BX26

Round 2 corrected
Length
1530 aa
Mass
175.6 kDa
Annotated
2026-04-28
85 papers in source corpus 13 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SYCP2 is a core structural component of the meiotic synaptonemal complex that organizes the chromosome axis and coordinates meiotic recombination. It forms heterotetrameric coiled-coil filaments with SYCP3 to constitute the axial/lateral elements of the synaptonemal complex, and its C-terminal region directly binds the transverse filament protein SYCP1, physically linking lateral elements to transverse filaments and thereby enabling chromosomal synapsis (PMID:16717126, PMID:19034475, PMID:30657449). SYCP2 also contains closure motifs that recruit meiotic HORMADs, and its loss abolishes not only SC assembly but also early meiotic recombination (Dmc1/Rad51 focus formation), causing male infertility in mice, zebrafish, and humans—where both gain- and loss-of-function variants cause non-obstructive azoospermia (PMID:30657449, PMID:32092049, PMID:31866047, PMID:37337432). When aberrantly expressed in breast and ovarian cancers, SYCP2 promotes R-loop-mediated transcription-coupled homologous recombination and RAD51 recruitment independently of BRCA1, a function regulated by ABL1 phosphorylation at Y739, conferring resistance to PARP inhibitors and platinum agents (PMID:38383600, PMID:40918650).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1998 Medium

    Identification of SYCP2 as a major lateral element protein of the synaptonemal complex resolved the molecular composition of the LE, revealing a coiled-coil-containing 173 kDa protein with meiosis-specific expression and structural similarity to yeast Red1.

    Evidence cDNA cloning from rat testis with monoclonal anti-SC antibodies and immunogold EM ultrastructural localization showing asymmetric LE distribution

    PMID:9592139 PMID:9933407

    Open questions at the time
    • No functional data; role inferred from localization only
    • Interaction partners not yet identified
    • Mouse genetic validation absent
  2. 2005 Medium

    Genetic studies in SYCP3-knockout mice (which also lack SYCP2 on chromosome cores) established that SYCP2/SYCP3 are dispensable for homologous chromosome alignment but essential for intimate synapsis, chromatin loop attachment specificity, and sex-specific maintenance of cohesin core integrity at diplotene.

    Evidence SYCP3-/- knockout mice analyzed by chromosome painting, FISH, and cohesin immunofluorescence in both sexes

    PMID:15237206 PMID:15870106

    Open questions at the time
    • SYCP2-specific contributions could not be separated from SYCP3 in these knockouts
    • Mechanism of cohesin stabilization by axial element proteins unknown
  3. 2006 High

    Direct demonstration that SYCP2 heterodimerizes with SYCP3 through its coiled-coil domain and is the primary determinant of axial element assembly resolved the hierarchical relationship between the two LE components—SYCP2 recruits SYCP3 rather than vice versa.

    Evidence Targeted deletion of SYCP2 coiled-coil domain in mice; in vitro binding and co-immunoprecipitation showing heterodimer formation; male sterility and female subfertility phenotype

    PMID:16717126

    Open questions at the time
    • How SYCP2 itself is recruited to chromosome axes without SYCP3 remained unclear
    • Higher-order assembly mechanism not resolved
  4. 2008 High

    Discovery that SYCP2's C-terminal region directly binds the C-terminus of SYCP1 established SYCP2 as the physical linker between lateral elements and transverse filaments, providing the architectural connection required for synapsis.

    Evidence Co-immunoprecipitation from meiotic cell extracts and yeast two-hybrid/interaction trap validation

    PMID:19034475

    Open questions at the time
    • Structural basis of the SYCP2–SYCP1 interface not determined
    • Whether the SYCP1-binding and SYCP3-binding functions of SYCP2 are simultaneously engaged was untested
  5. 2019 High

    Reconstitution of SYCP2–SYCP3 heterotetrameric filaments and identification of HORMAD-recruiting closure motifs in SYCP2 unified the structural and signaling functions of the chromosome axis, revealing a conserved filament architecture shared with yeast Red1 and plant ASY3/ASY4.

    Evidence In vitro structural reconstitution, electron microscopy of filaments, closure motif identification

    PMID:30657449

    Open questions at the time
    • Atomic-resolution structure of the SYCP2–SYCP3 heterotetramer not yet available
    • How HORMAD recruitment by closure motifs is temporally regulated in vivo is unknown
  6. 2019 High

    Human genetic evidence established that both overexpression and heterozygous loss-of-function of SYCP2 cause male infertility, demonstrating dosage sensitivity and implicating SYCP2 as a Mendelian disease gene for non-obstructive azoospermia.

    Evidence Balanced translocation t(20;22) with overexpression validated by RNA-seq; heterozygous frameshift variants in additional infertile males; yeast SC modeling

    PMID:31866047

    Open questions at the time
    • Mechanism by which SYCP2 overexpression disrupts SC integrity not molecularly defined
    • Penetrance and genotype-phenotype correlations in larger cohorts not established
  7. 2020 High

    Zebrafish Sycp2 knockout demonstrated that SYCP2 is required not only for SC assembly but also for early meiotic recombination (Dmc1/Rad51 focus formation), extending its function beyond a purely structural role to an essential upstream regulator of recombination initiation.

    Evidence ENU and TALEN-generated zebrafish knockouts; immunofluorescence for Dmc1/Rad51, RPA, and γH2AX

    PMID:32092049

    Open questions at the time
    • Whether SYCP2 promotes recombination directly or indirectly through HORMAD recruitment was not distinguished
    • Applicability to mammalian female meiosis untested
  8. 2023 Medium

    A homozygous SYCP2 frameshift variant causing zygotene arrest confirmed autosomal recessive inheritance as an additional mode of SYCP2-related human infertility, complementing the earlier dominant mechanism.

    Evidence Whole exome sequencing, meiotic chromosomal spread, and immunofluorescence in an azoospermic patient

    PMID:37337432

    Open questions at the time
    • Single family; independent replication in additional homozygous individuals needed
    • Functional rescue experiment not performed
  9. 2024 High

    Discovery that aberrantly expressed SYCP2 in cancers promotes R-loop-mediated transcription-coupled homologous recombination and RAD51 recruitment independently of BRCA1 revealed a non-meiotic gain-of-function that confers resistance to PARP and TOP1 inhibitors.

    Evidence SYCP2 knockdown/overexpression in breast and ovarian cancer cells; R-loop immunofluorescence; RAD51 foci quantification; PARP/TOP1 inhibitor sensitivity assays; clinical cohort validation

    PMID:38383600

    Open questions at the time
    • Which domain of SYCP2 mediates R-loop recognition was not mapped
    • Whether this function requires SYCP3 co-expression in tumors is unknown
  10. 2025 High

    Identification of ABL1 as a kinase that phosphorylates SYCP2 at Y739 to promote its R-loop and RAD51-related function provided a regulatory mechanism for SYCP2's oncogenic DNA repair activity and a therapeutic vulnerability (ABL1 inhibitors) in platinum-resistant ovarian cancer.

    Evidence Phosphosite mutagenesis, ABL1 inhibitor sensitivity in vitro and in vivo, colocalization of ABL1/SYCP2 at R-loop sites

    PMID:40918650

    Open questions at the time
    • Whether additional kinases phosphorylate SYCP2 in cancer contexts is unknown
    • Structural basis of how Y739 phosphorylation alters SYCP2 activity not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic-resolution structure of the SYCP2–SYCP3 heterotetramer, the mechanism by which SYCP2 closure motifs temporally regulate HORMAD recruitment in vivo, whether SYCP2's cancer R-loop function requires its meiotic interaction partners (SYCP3, SYCP1), and the full genotype-phenotype spectrum of SYCP2 variants in human infertility.
  • No high-resolution structure of SYCP2–SYCP3 complex
  • Temporal regulation of HORMAD recruitment undefined
  • Cancer mechanism may involve unknown co-factors

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0003677 DNA binding 2
Localization
GO:0005694 chromosome 6 GO:0005634 nucleus 4
Pathway
R-HSA-1474165 Reproduction 5 R-HSA-1640170 Cell Cycle 3 R-HSA-1643685 Disease 2 R-HSA-73894 DNA Repair 2
Partners
ABL1RAD51SYCP1SYCP3
Complex memberships
Synaptonemal complex lateral element (SYCP2–SYCP3 heterotetramer)

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 SCP2 (SYCP2) was identified as a major protein component (173 kDa) of the lateral elements of synaptonemal complexes in rat, transcribed specifically in testis during meiotic prophase. The C-terminus contains a coiled-coil domain, two clusters of S/T-P motifs flanking a basic central region, and potential phosphorylation sites for p34(cdc2), cAMP/cGMP-dependent kinases. Secondary structure similarity to yeast Red1 suggested a role in structural organization of meiotic prophase chromosomes. cDNA cloning from rat testis using monoclonal anti-SC antibodies, sequence analysis, Northern blot Nucleic acids research Medium 9592139
1998 SCP2 (SYCP2) and SCP3 both localize to the lateral elements of synaptonemal complexes in rat spermatocytes, with SCP2 labeling showing an asymmetrical distribution (shoulder at the inner side of the LE) and labeling of fuzzy connections/bridges between LEs not labeled by anti-SCP3 antibodies, indicating distinct sub-structural positions within the lateral element. Immunogold electron microscopy on ultrathin sections of rat testicular tissue using antisera against non-overlapping SCP2 fragments and SCP3 Chromosoma Medium 9933407
2004 In the absence of SYCP3 (which also eliminates SYCP2 from chromosome cores), homologous chromosome alignment is maintained, indicating that alignment is not a function of SYCP2/SYCP3 core components but may be mediated by chromatin-chromatin interactions. However, SYCP2 and SYCP3 are required for intimate chromosomal synapsis and for specificity of chromatin loop attachment to chromosome cores, as exogenous lambda phage sequences show multiple aberrant attachments to cores in SYCP3-/- males lacking both proteins. Whole chromosome painting and chromatin loop analysis in SYCP3-/- knockout mice; fluorescence in situ hybridization with centromeric major satellite and transgene sequences Cytogenetic and genome research Medium 15237206
2005 SYCP2 and SYCP3 are required for maintenance of cohesin core integrity at the diplotene stage of meiosis in female germ cells; in the absence of SYCP3 (which also removes SYCP2), cohesin cores associated with female meiotic chromosomes disassemble prematurely at diplotene. However, SYCP3 and SYCP2 are not required for centromere cohesion at the metaphase-I stage in male germ cells, demonstrating a temporally restricted and sex-specific function. Analysis of cohesin complex protein distribution by immunofluorescence in Sycp3-deficient male and female mice Journal of cell science Medium 15870106
2006 SYCP2 forms heterodimers with SYCP3 both in vitro and in vivo, mediated by an evolutionarily conserved coiled-coil domain in SYCP2. Deletion of this coiled-coil domain in mice causes male sterility due to failure to form axial elements and chromosomal synapsis; the mutant SYCP2 protein localizes to axial chromosomal cores but SYCP3 does not, establishing SYCP2 as a primary determinant of axial/lateral element assembly and required for SYCP3 incorporation into synaptonemal complexes. Females are subfertile rather than sterile, demonstrating sexual dimorphism. In vitro binding assay, co-immunoprecipitation, targeted deletion of coiled-coil domain in mice, immunofluorescence on spermatocytes and fetal oocytes The Journal of cell biology High 16717126
2008 SYCP2 directly interacts with the C-terminus of SYCP1 (the transverse filament protein), mediated by the C-terminal region of SYCP2, as demonstrated by co-immunoprecipitation from meiotic cell extracts and yeast two-hybrid assays confirmed by interaction trap experiments. This positions SYCP2 as a linker between lateral element (SYCP3) and transverse filament (SYCP1) components, providing the missing connecting link between LEs and TFs essential for chromosome synapsis. Co-immunoprecipitation from meiotic cell extracts, yeast two-hybrid system, interaction trap assays Chromosoma High 19034475
2015 SYCP2 is an ancient metazoan protein present in the common ancestor of metazoans more than 500 million years ago, grouping with SYCP1, SYCP3, SYCE2, and TEX12 as ancient synaptonemal complex components identified across basal-branching metazoans by bioinformatic analysis and RNA/protein expression studies. Bioinformatic phylogenetic analysis, RNA expression analysis, protein expression analysis across metazoan species Cytogenetic and genome research Low 25831978
2019 SYCP2 and SYCP3 form a heterotetrameric coiled-coil assembly (analogous to yeast Red1 homotetramers and plant ASY3:ASY4 heterotetramers) that further oligomerizes into micron-length filaments constituting the meiotic chromosome axis core. SYCP2 contains 'closure motifs' that recruit meiotic HORMADs, the master regulators of meiotic recombination. This filamentous architecture is conserved across fungi, mammals, and plants. Structural reconstitution, electron microscopy of filament assemblies, identification of HORMAD-binding closure motifs, sequence/structural homology analysis with yeast Red1 and plant ASY3/ASY4 eLife High 30657449
2019 Overexpression of SYCP2 from a derivative chromosome (der(20)) due to a balanced chromosomal aberration t(20;22) in an infertile male causes severe oligozoospermia by disrupting the structural integrity of the synaptonemal complex; heterozygous frameshift variants in SYCP2 are independently associated with cryptozoospermia and azoospermia in additional infertile males, establishing an autosomal dominant mechanism of SYCP2-mediated male infertility in humans. RNA sequencing showing exclusive overexpression from der(20); modeling in budding yeast showing disrupted SC structural integrity; exome sequencing identifying heterozygous frameshift variants in additional infertile males American journal of human genetics High 31866047
2020 In zebrafish, Sycp2 is required for assembly of the synaptonemal complex initiated near telomeres, for early meiotic recombination, and for homologous pairing in spermatocytes. Sycp2 knockout spermatocytes show largely diminished foci of meiotic recombinases Dmc1/Rad51, RPA, and γH2AX signals, demonstrating that Sycp2 is required not only for SC structural assembly but also for initiation of meiotic recombination. N-ethyl-N-nitrosourea mutagenesis screen, TALEN-generated knockout, immunofluorescence for SC components and recombination markers (Dmc1/Rad51, RPA, γH2AX) PLoS genetics High 32092049
2023 A homozygous frameshift variant in SYCP2 (c.2689_2690insT) causes meiotic arrest at the zygotene stage and non-obstructive azoospermia in a patient, demonstrating autosomal recessive inheritance in this case; HE, immunofluorescence, and meiotic chromosomal spread analyses confirmed zygotene arrest. Whole exome sequencing, Sanger sequencing, hematoxylin-eosin histology, immunofluorescence, meiotic chromosomal spread analysis Clinical genetics Medium 37337432
2024 SYCP2, aberrantly expressed in breast and ovarian cancers, enhances repair of DNA double-strand breaks through transcription-coupled homologous recombination (TC-HR) by promoting R-loop formation at DSBs and facilitating RAD51 recruitment independently of BRCA1. SYCP2 loss impairs RAD51 localization, reduces TC-HR, and sensitizes tumor cells to PARP and topoisomerase I (TOP1) inhibitors, conferring broad resistance to DNA damage response drugs. SYCP2 knockdown/overexpression in breast and ovarian cancer cells; R-loop immunofluorescence; RAD51 recruitment assays; PARP/TOP1 inhibitor sensitivity assays; clinical cohort correlation Nature communications High 38383600
2025 ABL1 tyrosine kinase phosphorylates SYCP2 at tyrosine Y739 within a [RK]-x(2,3)-[DE]-x(2,3)-Y phosphorylation motif. ABL1-mediated Y739 phosphorylation promotes SYCP2 function at sites of R-loops by facilitating RAD51 localization and transcription-coupled homologous recombination (TC-HR), contributing to platinum resistance in ovarian cancer. ABL1 and SYCP2 colocalize at R-loop sites after DNA damage, and abolishing Y739 phosphorylation renders cancer cells sensitive to ABL1 inhibitors. Phosphorylation motif identification; site-directed mutagenesis of Y739; ABL1 inhibitor sensitivity assays in vitro and in vivo; immunofluorescence colocalization of ABL1/SYCP2 at R-loops; RAD51 recruitment assays NAR cancer High 40918650

Source papers

Stage 0 corpus · 85 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2006 Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. The Journal of cell biology 221 16717126
1985 The Streptomyces plasmid SCP2*: its functional analysis and development into useful cloning vectors. Gene 186 2995202
2016 Regulating the construction and demolition of the synaptonemal complex. Nature structural & molecular biology 175 27142324
2001 The DNA sequence and comparative analysis of human chromosome 20. Nature 168 11780052
1998 SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat. Nucleic acids research 150 9592139
2010 Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Human reproduction (Oxford, England) 123 20378615
2021 Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 113 34349018
2019 A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. eLife 98 30657449
1998 Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat. Chromosoma 84 9933407
2005 SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. Journal of cell science 83 15870106
2019 SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility. American journal of human genetics 72 31866047
1994 The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2). Genomics 65 7698762
2004 Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis. Journal of lipid research 56 15342684
2015 Deregulation of SYCP2 predicts early stage human papillomavirus-positive oropharyngeal carcinoma: A prospective whole transcriptome analysis. Cancer science 48 26334652
2022 NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nature immunology 46 36138187
2020 Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes. PLoS genetics 43 32092049
2008 Protein SYCP2 provides a link between transverse filaments and lateral elements of mammalian synaptonemal complexes. Chromosoma 43 19034475
2004 Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment. Cytogenetic and genome research 41 15237206
2015 SR protein kinases promote splicing of nonconsensus introns. Nature structural & molecular biology 37 26167880
1988 A mass spectrometric study of the structure of sterol carrier protein SCP2 from rat liver. Biochemical and biophysical research communications 37 3395344
2019 MicroRNA-15a Regulates the Differentiation of Intramuscular Preadipocytes by Targeting ACAA1, ACOX1 and SCP2 in Chickens. International journal of molecular sciences 36 31434294
2022 Role of STAR and SCP2/SCPx in the Transport of Cholesterol and Other Lipids. International journal of molecular sciences 34 36292972
2003 Streptomyces coelicolor A3(2) plasmid SCP2*: deductions from the complete sequence. Microbiology (Reading, England) 34 12624212
1988 Intracellular redistribution of SCP2 in Leydig cells after hormonal stimulation may contribute to increased pregnenolone production. Biochemical and biophysical research communications 27 3395346
2023 NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis. Nature communications 25 37770465
1988 Regulation of sterol carrier protein2 (SCP2) levels in the soluble fraction of rat Leydig cells. Kinetics and the possible role of calcium influx. Molecular and cellular endocrinology 25 3371541
2007 Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members. Journal of lipid research 24 18084051
1993 Analysis of the transfer region of the Streptomyces plasmid SCP2. Molecular microbiology 24 7968512
2023 SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis. Cell death discovery 22 37422468
2010 Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects. Journal of lipid research 22 20656919
2007 A new N-terminal recognition domain in caveolin-1 interacts with sterol carrier protein-2 (SCP-2). Biochemistry 21 17580960
2019 SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation. Journal of experimental & clinical cancer research : CR 19 31519191
2007 Conformational plasticity of the lipid transfer protein SCP2. Biochemistry 19 17566986
2013 Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop. The Biochemical journal 18 23909465
2006 Molecular cloning and characterization of Bombyx mori sterol carrier protein x/sterol carrier protein 2 (SCPx/SCP2) gene. DNA sequence : the journal of DNA sequencing and mapping 16 17343205
1998 In pre-sterol carrier protein 2 (SCP2) in solution the leader peptide 1-20 is flexibly disordered, and residues 21-143 adopt the same globular fold as in mature SCP2. Cellular and molecular life sciences : CMLS 16 9711242
2024 Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair. Nature communications 15 38383600
2022 Recombination rates in pigs differ between breeds, sexes and individuals, and are associated with the RNF212, SYCP2, PRDM7, MEI1 and MSH4 loci. Genetics, selection, evolution : GSE 14 35596132
2015 Protein SYCP2 is an ancient component of the metazoan synaptonemal complex. Cytogenetic and genome research 14 25831978
2006 Characterization of SCP-2 from Euphorbia lagascae reveals that a single Leu/Met exchange enhances sterol transfer activity. The FEBS journal 14 17212780
2018 Synergistic roles of acyl-CoA binding protein (ACBP1) and sterol carrier protein 2 (SCP2) in Toxoplasma lipid metabolism. Cellular microbiology 13 30362657
2016 Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice. Biochimica et biophysica acta. Molecular and cell biology of lipids 13 27940000
2022 SCP2 variant is associated with alterations in lipid metabolism, brainstem neurodegeneration, and testicular defects. Human genomics 12 35996156
1996 Structure and chromosomal assignment of the murine sterol carrier protein 2 gene (Scp2) and two related pseudogenes by in situ hybridization. Cytogenetics and cell genetics 12 8751375
1991 Sterol carrier protein2 (SCP2)-like protein in rat aorta. Artery 12 2021352
2021 Basic pH reversed-phase liquid chromatography (bRPLC) in combination with tip-based strong cation exchange (SCX-Tip), ReST, an efficient approach for large-scale cross-linked peptide analysis. Analytica chimica acta 11 34535262
2021 LINC00261 elevation inhibits angiogenesis and cell cycle progression of pancreatic cancer cells by upregulating SCP2 via targeting FOXP3. Journal of cellular and molecular medicine 11 34541823
2021 A peroxisomal sterol carrier protein 2 (Scp2) contributes to lipid trafficking in differentiation and virulence of the insect pathogenic fungus Beauveria bassiana. Fungal genetics and biology : FG & B 11 34906632
2015 Synthesis, purification and crystallographic studies of the C-terminal sterol carrier protein type 2 (SCP-2) domain of human hydroxysteroid dehydrogenase-like protein 2. Acta crystallographica. Section F, Structural biology communications 11 26144236
1979 Fertility properties and regulation of antimicrobial substance production by plasmid SCP2 of Streptomyces coelicolor. Journal of bacteriology 11 500559
2019 The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry. The Biochemical journal 10 30573650
2018 Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice. Biochimica et biophysica acta. Molecular and cell biology of lipids 10 29307784
1999 Isolation and characterization of the human SCP2 cDNA and chromosomal localization of the gene. Mammalian genome : official journal of the International Mammalian Genome Society 9 10341103
1995 Expression and purification of two recombinant sterol-carrier proteins: SCPX and SCP2. Protein expression and purification 9 7606169
2024 CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo. iScience 8 38591009
1996 Expression of sterol carrier protein 2 (SCP2) in human adrenocortical tissue. European journal of endocrinology 8 8640304
2025 EndoMAP.v1 charts the structural landscape of human early endosome complexes. Nature 6 40437099
2016 The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism. Proteins 6 27093562
1993 Two yeast peroxisomal proteins crossreact with an antiserum against human sterol carrier protein 2 (SCP-2). Biochimica et biophysica acta 6 8499465
2023 A homozygous frameshift variant in SYCP2 caused meiotic arrest and non-obstructive azoospermia. Clinical genetics 5 37337432
2023 E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination. International immunopharmacology 5 37696143
2022 Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells. Cancers 5 35158823
2016 Solution Nuclear Magnetic Resonance Studies of Sterol Carrier Protein 2 Like 2 (SCP2L2) Reveal the Insecticide Specific Structural Characteristics of SCP2 Proteins in Aedes aegypti Mosquitoes. Biochemistry 5 27508310
2010 Characterization of the tyrosine recombinase MrpA encoded by the Streptomyces coelicolor A3(2) plasmid SCP2*. Archives of microbiology 5 21165603
2013 Increased bile lithogenicity by SCP2 via HMGCR and CYP7A1 regulation in human hepatocytes. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 4 24226717
1994 High-frequency homologous plasmid-plasmid recombination coupled with conjugation of plasmid SCP2* in Streptomyces. Molecular microbiology 4 7885233
1991 Purification, characterization and comparison with mammalian SCP2 of a chicken SCP2-like protein. Comparative biochemistry and physiology. B, Comparative biochemistry 4 1799965
2024 Novel Loss-of-Function SYCP2 Variants in Infertile Males Upgrade the Gene-Disease Clinical Validity Classification for SYCP2 and Male Infertility to Strong. Genes 3 39202451
2020 A novel 1p33p32.2 deletion involving SCP2, ORC1, and DAB1 genes in a patient with craniofacial dysplasia, short stature, developmental delay, and leukoencephalopathy: A case report. Medicine 3 33157955
2018 Binding properties of sterol carrier protein 2 (SCP2) characterized using Laurdan. Biochimica et biophysica acta. Proteins and proteomics 3 30282612
2012 Ursodeoxycholic acid lowers bile lithogenicity by regulating SCP2 expression in rabbit cholesterol gallstone models. EXCLI journal 3 27847447
2005 [Cloning and characterization of a novel mouse short-chain dehydrogenase/reductases cDNA mHsdl2#, encoding a protein with a SDR domaid and a SCP2 domain]. Molekuliarnaia biologiia 3 16240713
2025 A novel loss-of-function SYCP2 variant causes asthenoteratozoospermia in infertile males. Frontiers in genetics 2 40432880
2022 In Silico and In Vivo Evaluation of Synthesized SCP-2 Inhibiting Compounds on Life Table Parameters of Helicoverpa armigera (Hübner). Insects 2 36555079
1982 [Genetic instability of the production of antibiotic substances controlled by the SCP2 plasmid of Streptomyces coelicolor A3(2)]. Genetika 2 6951794
2025 ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer. NAR cancer 1 40918650
2023 Case report: Episodic psychosis caused by a novel SCP2 splicing mutation. Frontiers in neurology 1 37905191
2005 Identification of SCP2165, a new SCP2-derived plasmid of Streptomyces coelicolor A3(2). Letters in applied microbiology 1 16162143
2026 Comprehensive pan-cancer analysis and experimental verification of the roles of SCP2 in colon adenocarcinoma. BMC cancer 0 41526827
2025 Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulation and Hepatocellular Carcinoma Progression. The Tohoku journal of experimental medicine 0 40993092
2025 Unveiling the expression and mechanistic role of SYCP2 in cervical lesions. Discover oncology 0 41182523
1983 [Structural peculiarities of the SCP2 plasmid of Streptomyces coelicolor A3(2)]. Molekuliarnaia biologiia 0 6304492
1981 [Plasmid SCP2 transfer by Streptomyces coelicolor A3(2) actinophages]. Genetika 0 7196857