Affinage

SYCP1

Synaptonemal complex protein 1 · UniProt Q15431

Length
976 aa
Mass
114.2 kDa
Annotated
2026-04-28
75 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SYCP1 is the major transverse filament protein of the meiotic synaptonemal complex (SC), essential for homologous chromosome synapsis, crossover formation, and proper meiotic progression in vertebrates. SYCP1 forms an obligate tetramer whose N-terminal four-helical bundle mediates cooperative head-to-head interactions at the SC midline while C-terminal coiled-coil dimers anchor at lateral elements, establishing the zipper-like lattice that spans the inter-homolog space (PMID:8660934, PMID:8660935, PMID:29915389). This SYCP1 lattice is actively remodeled during synapsis by the central element protein SYCE3, which converts SYCP1 tetramers into SYCP1–SYCE3 heterotrimers and nucleates a new integrated scaffold that recruits additional central element complexes SYCE1–SIX6OS1 and SYCE2–TEX12 (PMID:36635604). Loss of SYCP1 in mouse and zebrafish permits axial element formation and homolog alignment but abolishes synapsis, blocks crossover maturation (loss of MLH1/MLH3 foci), causes meiotic arrest or aneuploidy, and in humans a homozygous SYCP1 frameshift variant is associated with severe oligozoospermia (PMID:15937223, PMID:33842489, PMID:35377450).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1996 High

    Establishing the polarity model of SC transverse filaments — how SYCP1 molecules are oriented within the complex — resolved a fundamental architectural question by showing that N-termini converge at the central element via head-to-head interaction while C-termini embed in lateral elements.

    Evidence Domain-specific antibody immunogold electron microscopy on rat spermatocytes combined with yeast two-hybrid for N-terminal self-interaction

    PMID:8660934 PMID:8660935

    Open questions at the time
    • Oligomeric state of SYCP1 was unknown
    • Molecular basis of head-to-head and axis-anchoring contacts unresolved
    • No functional/genetic test of the polarity model
  2. 1999 Medium

    Demonstrating that SYCP1 is phosphorylated during the pachytene-to-metaphase I transition linked SC disassembly to post-translational regulation, while promoter dissection showed that a minimal region drives pachytene-specific expression in males.

    Evidence In vitro kinase assays with staged spermatocyte extracts; transgenic reporter mice with promoter deletions

    PMID:10096061 PMID:9914155

    Open questions at the time
    • Identity of the kinase(s) responsible for SYCP1 phosphorylation was not determined
    • Causal link between phosphorylation and SC disassembly not established
    • Regulatory elements controlling female meiotic expression unknown
  3. 2004 High

    Reconstituting SYCP1 self-assembly in non-meiotic cells established that SYCP1 is a primary determinant of SC-like structure formation, with distinct roles for the N-terminal, coiled-coil, and C-terminal domains.

    Evidence Ectopic expression of wild-type and mutant SYCP1 in COS-7 cells, analyzed by electron microscopy

    PMID:15496453

    Open questions at the time
    • Whether self-assembly in somatic cells faithfully represents in vivo SC architecture was unclear
    • Binding partners required for native SC assembly not addressed
  4. 2005 High

    The Sycp1 knockout mouse proved that SYCP1 is required for synapsis and crossover formation but dispensable for axial element assembly and homolog alignment, defining SYCP1's non-redundant role in meiosis and linking it to central element protein recruitment.

    Evidence Sycp1 gene knockout in mouse with cytological, immunofluorescence, and recombination analysis; identification of SYCE1/SYCE2 as SYCP1-dependent central element components by co-IP and yeast two-hybrid

    PMID:15937223 PMID:15944401

    Open questions at the time
    • Mechanism by which SYCP1 promotes crossover maturation (MLH1/MLH3 loading) was unknown
    • Order of central element protein recruitment unclear
  5. 2018 High

    Solving the crystal structure of SYCP1 revealed it forms an obligate tetramer and identified two discrete self-assembly interfaces — N-terminal cooperative head-to-head and C-terminal back-to-back contacts — explaining how the zipper-like SC lattice is built.

    Evidence X-ray crystallography of human SYCP1 fragments, validated by analytical ultracentrifugation and small-angle X-ray scattering

    PMID:29915389

    Open questions at the time
    • How the lattice accommodates central element proteins was unknown
    • In vivo validation of specific lattice contacts not yet performed
    • Full-length structure remained unresolved
  6. 2023 High

    Discovery that SYCE3 actively remodels the SYCP1 lattice — converting tetramers to SYCP1–SYCE3 heterotrimers and nucleating a new integrated scaffold — provided the first mechanistic model for how the SC transitions from initial SYCP1 self-assembly to a mature central element that recruits downstream complexes.

    Evidence Biochemical reconstitution, X-ray crystallography, and separation-of-function mutations in mice

    PMID:36635604

    Open questions at the time
    • Temporal dynamics of remodeling in vivo not captured
    • Whether remodeling is reversible during SC disassembly is unknown
  7. 2023 High

    In vivo mutagenesis of the conserved N-terminal head-to-head interface (L106E) confirmed that this specific lattice contact is essential for synapsis initiation and crossover formation, validating the structural model in a physiological context.

    Evidence CRISPR/knock-in L106E point mutation in mice with cytological and molecular analysis

    PMID:37862414

    Open questions at the time
    • Whether partial disruption of the interface can support partial synapsis is untested
    • Contribution of back-to-back C-terminal interface not yet tested by equivalent in vivo mutation
  8. 2022 Medium

    Identification of a homozygous SYCP1 frameshift variant associated with severe oligozoospermia in humans extended the functional requirement of SYCP1 to human male fertility.

    Evidence Whole-exome sequencing of infertile men, Sanger validation, immunofluorescence of semen cells

    PMID:35377450

    Open questions at the time
    • Single family studied; replication in independent cohorts needed
    • Functional rescue experiment not performed
    • Mechanistic inference relies on computational modeling rather than direct biochemistry
  9. 2025 Medium

    Zebrafish sycp1 mutant analysis revealed sex-specific consequences: male sterility with meiotic arrest versus female fertility with offspring aneuploidy, demonstrating that SYCP1-dependent synapsis is differentially required for male and female meiotic fidelity.

    Evidence Zebrafish sycp1 loss-of-function mutants with fertility and offspring genome analysis

    PMID:40911633

    Open questions at the time
    • Molecular basis for sex-specific tolerance of synapsis failure unknown
    • Whether compensatory mechanisms exist in female meiosis not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the identity of kinases and phosphatases controlling SYCP1 disassembly at the pachytene-diplotene transition; the structural basis of SYCP1 C-terminal anchoring to lateral element proteins; whether the back-to-back C-terminal lattice interface is essential in vivo; and the full temporal sequence and regulation of SC remodeling from initial SYCP1 lattice to mature central element.
  • No kinase/phosphatase identified for SYCP1 disassembly regulation
  • No structural model of SYCP1 C-terminus interaction with lateral element proteins (SYCP2/SYCP3)
  • In vivo validation of C-terminal back-to-back interface lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 5
Localization
GO:0005694 chromosome 4
Pathway
R-HSA-1474165 Reproduction 4
Partners
SIX6OS1SYCE1SYCE2SYCE3TEX12
Complex memberships
SYCP1-SYCE3 heterotrimersynaptonemal complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 The N-terminal end of SYCP1 is localized within the central element of the synaptonemal complex, while the C-terminal end is close to or within the lateral element. The N-terminus of SYCP1 interacts with itself (head-to-head), as demonstrated by yeast two-hybrid, suggesting that transverse filaments consist of pairs of SYCP1 dimers organized head-to-head with C-termini anchored in lateral elements. Immunoelectron microscopy, yeast two-hybrid system Experimental cell research High 8660934
1996 SCP1 molecules in rat synaptonemal complexes are oriented with their C-terminus in the inner half of the lateral element, the central coiled-coil projecting through the central region, and the N-terminus overlapping with N-termini from opposite lateral elements in the central element, establishing the polarity model of transverse filament organization. Immunoelectron microscopy on Lowicryl sections and surface-spread spermatocytes using antibodies against N-terminal, middle, and C-terminal fragments of SCP1 Experimental cell research High 8660935
2004 SYCP1 is a primary determinant of synaptonemal complex assembly: when expressed ectopically in COS-7 cells (which lack SC proteins), SYCP1 self-assembles into polycomplex structures resembling SCs. Mutations altering the length of the central alpha-helical domain change polycomplex width; deletions of either the N- or C-terminal non-helical domains impair polycomplex assembly in distinct ways. Ectopic expression in COS-7 cells, mutagenesis, electron microscopy Molecular biology of the cell High 15496453
2005 Mouse SYCP1 (transverse filament protein) is required for meiotic chromosome synapsis, crossover formation, and XY body formation. Sycp1-/- spermatocytes form normal axial elements and homolog alignment but fail to synapse; recombination intermediates (RAD51/DMC1, RPA, MSH4 foci) accumulate but MLH1/MLH3 foci (crossover markers) are absent, and crossovers are rare. Gene knockout in mouse, immunofluorescence, electron microscopy, recombination analysis Genes & development High 15937223
2005 Two novel proteins, SYCE1 and CESC1 (later SYCE2), are exclusive components of the central element of the mammalian synaptonemal complex. They physically interact with the transverse filament protein SYCP1, and their localization to the central element depends on recruitment by SYCP1. Co-immunoprecipitation, yeast two-hybrid, immunofluorescence, microarray expression profiling Journal of cell science High 15944401
1999 SYN1/SCP1 and COR1/SCP3 are efficiently phosphorylated in vitro by extracts from isolated pachytene spermatocytes, and their phosphorylation correlates with removal from chromosomes during the pachytene-to-metaphase I transition; extracts from metaphase I cells (with displaced SCP1/SCP3) lack this kinase capability. In vitro kinase assay with spermatocyte extracts, okadaic acid-induced meiotic activation, immunofluorescence Journal of cell science Medium 9914155
2018 X-ray crystallography and biophysical studies reveal that human SYCP1 forms an obligate tetramer: an N-terminal four-helical bundle bifurcates into two elongated C-terminal dimeric coiled-coils. SYCP1 self-assembles into a zipper-like lattice via two sites: cooperative N-terminal head-to-head assembly at the SC midline, and C-terminal back-to-back interactions on the chromosome axis. X-ray crystallography, analytical ultracentrifugation, small-angle X-ray scattering, biophysical characterization Nature structural & molecular biology High 29915389
2016 The C-terminal coiled-coil domain of SYCP1 forms an asymmetric, anti-parallel dimer in solution, as determined by X-ray crystallography. X-ray crystallography, solution biophysics PloS one Medium 27548613
2023 The CE protein SYCE3 actively remodels the SYCP1 lattice during synapsis: SYCP1 tetramers undergo conformational change into 2:1 SYCP1-SYCE3 heterotrimers upon SYCE3 binding, disrupting the SYCP1 assembly interfaces. SYCE3 then establishes a new lattice by self-assembly that tethers SYCP1 dimers together, and also recruits CE complexes SYCE1-SIX6OS1 and SYCE2-TEX12. Biochemical reconstitution, X-ray crystallography, separation-of-function mutagenesis in mice, pulldown assays Nature structural & molecular biology High 36635604
2023 The conserved N-terminal head-to-head interface of SYCP1 (involving residue L106) is essential for meiotic chromosome synapsis in vivo. A L106E point mutation abolishes synapsis in mice; homologs align and recruit low levels of mutant SYCP1 and other SC proteins, but no synapsis occurs, crossover formation fails, and meiosis arrests. CRISPR/knock-in mouse mutagenesis, immunofluorescence, molecular dynamics simulation Science advances High 37862414
1999 The Sycp1 promoter region (from -54 to +102 relative to transcription start) is sufficient for stage-specific expression in pachytene spermatocytes in transgenic mice; an upstream enhancer element between -54 and -260 quantitatively regulates expression. None of the testis-active promoter sequences drive expression during female meiosis. Transgenic reporter mice, promoter deletion analysis Mechanisms of development Medium 10096061
2021 In zebrafish, Sycp1 is required for homologous chromosome alignment/synapsis but not for subtelomeric DNA double-strand break formation. sycp1 mutant spermatocytes form axial elements, pair at chromosome ends, show normal γH2AX, Dmc1/Rad51 and RPA signals near telomeres, but fail to complete synapsis; Hormad1 persists along axes while Iho1 dissociation is DSB-dependent. Zebrafish sycp1 mutant analysis, immunofluorescence, cytology Frontiers in cell and developmental biology Medium 33842489
2022 A homozygous frameshift mutation in human SYCP1 (c.2892delA: p.K967Nfs*1) that deletes the C-tail region is associated with severe oligozoospermia in men; HADDOCK modeling indicates reduced DNA-binding by the truncated protein, and immunodetection shows γH2AX signals and 40% DNA fragmentation index in mutant semen cells, suggesting impaired DSB repair. Whole-exome sequencing, Sanger sequencing, immunofluorescence, computational modeling Molecular human reproduction Medium 35377450
2025 In zebrafish, sycp1 mutant males are sterile with spermatocytes that transit prophase I but arrest at metaphase I or II, while sycp1 mutant females are fertile but produce offspring with somatic mosaic aneuploidy, demonstrating that SYCP1-dependent synapsis is required for efficient meiotic DSB repair and proper chromosome segregation. Zebrafish sycp1 mutant genetic analysis, cytology, fertility/offspring analysis PLoS genetics Medium 40911633
2020 A-MYB transcription factor binds the promoter of lncRNA-Gm2044 (at -819 bp) and promotes its expression; lncRNA-Gm2044 acts as a miR-335-3p sponge to protect Sycp1 mRNA from degradation, thereby up-regulating SYCP1 protein in mouse spermatocytes and reducing GC-2spd(ts) cell proliferation. ChIP assay, luciferase reporter, overexpression/knockdown in cell line, qPCR Differentiation; research in biological diversity Medium 32585553
2025 SYCP1 is aberrantly re-expressed in breast cancer and other tumors, where it binds chromatin at regulatory elements, controls transcriptional programs for DNA repair (CCNB1, PCNA, RAD51C, H2AX), interfaces with chromatin remodeling complexes and transcription factors SP1/SP2, and promotes tumor cell proliferation, migration, and resistance to cisplatin and gemcitabine. Loss of SYCP1 impairs DNA repair kinetics and reduces proliferation. Integrative genomics (ChIP-seq), proteomics, loss-of-function (knockdown), drug sensitivity assays, co-IP bioRxivpreprint Medium bio_10.1101_2025.09.18.677087

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes & development 541 17403776
2005 Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes & development 378 15937223
2005 Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. Journal of cell science 163 15944401
1996 Localization of the N-terminus of SCP1 to the central element of the synaptonemal complex and evidence for direct interactions between the N-termini of SCP1 molecules organized head-to-head. Experimental cell research 114 8660934
1996 Organization of SCP1 protein molecules within synaptonemal complexes of the rat. Experimental cell research 102 8660935
2006 Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Molecular cell 94 17157258
1977 Genetic determination of methylenomycin synthesis by the SCP1 plasmid of Streptomyces coelicolor A3(2). Journal of general microbiology 91 833570
2004 Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes. Molecular biology of the cell 88 15496453
2004 SCP1, a 356,023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolor A3(2). Molecular microbiology 84 15009889
2018 Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly. Nature structural & molecular biology 61 29915389
2017 The Cytochrome P450 Gene CsCYP85A1 Is a Putative Candidate for Super Compact-1 (Scp-1) Plant Architecture Mutation in Cucumber (Cucumis sativus L.). Frontiers in plant science 58 28303144
2020 Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein. Oncogene 57 32973332
2019 Production, purification, and in vivo evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccine. International immunopharmacology 56 31499268
1991 Physical characterization of SCP1, a giant linear plasmid from Streptomyces coelicolor. Journal of bacteriology 56 1847368
2006 Structural components of the synaptonemal complex, SYCP1 and SYCP3, in the medaka fish Oryzias latipes. Experimental cell research 55 16764855
1996 Mouse fetal antigen 1 (mFA1), the circulating gene product of mdlk, pref-1 and SCP-1: isolation, characterization and biology. Journal of reproduction and fertility 53 8882295
2003 SCP1 encodes an actin-bundling protein in yeast. The Biochemical journal 50 12868959
1999 Meiotic activation of rat pachytene spermatocytes with okadaic acid: the behaviour of synaptonemal complex components SYN1/SCP1 and COR1/SCP3. Journal of cell science 50 9914155
1997 Glycosylation analysis and protein structure determination of murine fetal antigen 1 (mFA1)--the circulating gene product of the delta-like protein (dlk), preadipocyte factor 1 (Pref-1) and stromal-cell-derived protein 1 (SCP-1) cDNAs. European journal of biochemistry 49 9118998
2008 Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis. The Journal of biological chemistry 37 18400761
2002 Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum. Cancer immunity 36 12747750
1999 Temporal and spatial control of the Sycp1 gene transcription in the mouse meiosis: regulatory elements active in the male are not sufficient for expression in the female gonad. Mechanisms of development 36 10096061
1997 Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene. Genomics 34 9119375
2010 Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein science : a publication of the Protein Society 33 20222012
2007 The telomere system of the Streptomyces linear plasmid SCP1 represents a novel class. Molecular microbiology 33 17367390
1992 Effect of induced molting on B cell and CT4 and CT8 T cell numbers in spleens and peripheral blood of White Leghorn hens. Poultry science 33 1361673
2020 Efficacy of co-immunization with the DNA and peptide vaccines containing SYCP1 and ACRBP epitopes in a murine triple-negative breast cancer model. Human vaccines & immunotherapeutics 32 32497486
2005 Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells. Blood 31 16030183
1999 The linear plasmid SCP1 of Streptomyces coelicolor A3(2) possesses a centrally located replication origin and shows significant homology to the transposon Tn4811. Plasmid 30 10545260
1995 cDNA sequence of the murine synaptonemal complex protein 1 (SCP1). Biochimica et biophysica acta 25 7548215
1992 The structure of an integrated copy of the giant linear plasmid SCP1 in the chromosome of Streptomyces coelicolor 2612. Molecular & general genetics : MGG 25 1311404
1992 Integration of SCP1, a giant linear plasmid, into the Streptomyces coelicolor chromosome. Gene 25 1319377
2015 SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62. Oncogene 24 25893300
1998 Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1. Journal of bacteriology 24 9573173
1976 Genetic studies on SCP1-prime strains of Streptomyces coelicolor A3(2). Journal of general microbiology 24 956772
2013 A tandem Kunitz protease inhibitor (KPI106)-serine carboxypeptidase (SCP1) controls mycorrhiza establishment and arbuscule development in Medicago truncatula. The Plant journal : for cell and molecular biology 23 23662629
2004 Two chimeric chromosomes of Streptomyces coelicolor A3(2) generated by single crossover of the wild-type chromosome and linear plasmid scp1. Journal of bacteriology 22 15375137
2023 Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3. Nature structural & molecular biology 19 36635604
2020 LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates Sycp1 expression as a miR-335-3p sponge in mouse spermatocyte-derived GC-2spd(ts) cells. Differentiation; research in biological diversity 18 32585553
2017 Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. eLife 18 28440748
2021 DUSP5 promotes osteogenic differentiation through SCP1/2-dependent phosphorylation of SMAD1. Stem cells (Dayton, Ohio) 16 34169608
2018 Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST). The Journal of biological chemistry 16 30217818
2001 Integrated structures of the linear plasmid SCP1 in two bidirectional donor strains of Streptomyces coelicolor A3(2). Molecular & general genetics : MGG 16 11212918
1990 Characterization of suppressor T cells for antibody production by chicken spleen cells. I. Antigen-induced suppressor cells are CT8+, TcR1+ (gamma delta) T cells. Immunology 16 2149122
2023 SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis. Science advances 15 37862414
2022 A rare frameshift mutation in SYCP1 is associated with human male infertility. Molecular human reproduction 14 35377450
2021 Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes. Frontiers in cell and developmental biology 14 33842489
2012 Gene cloning, molecular modeling, and phylogenetics of serine protease P32 and serine carboxypeptidase SCP1 from nematophagous fungi Pochonia rubescens and Pochonia chlamydosporia. Canadian journal of microbiology 14 22690687
1997 The Sycp1 loci of the mouse genome: successive retropositions of a meiotic gene during the recent evolution of the genus. Genomics 14 9286707
2016 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. Biochemical and biophysical research communications 12 27751849
2014 The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1. BMB reports 11 24755554
2010 Arabidopsis SCP1-like small phosphatases differentially dephosphorylate RNA polymerase II C-terminal domain. Biochemical and biophysical research communications 11 20513350
2016 Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals Non-Canonical Anti-Parallel Dimeric Structure of Transverse Filament at the Synaptonemal Complex. PloS one 10 27548613
2006 The Sycp1-Cre transgenic mouse and male germ cell inhibition of NF-kappa b. Journal of andrology 10 16775250
2007 Identification of low-molecular-weight protein (SCP1) from shark cartilage with anti-angiogenesis activity and sequence similarity to parvalbumin. Journal of pharmaceutical and biomedical analysis 9 18093782
1990 Characterization of suppressor T cells for antibody production by chicken spleen cells. II. Comparison of CT8+ cells from concanavalin A-injected normal and bursa cell-injected agammaglobulinaemic chickens. Immunology 8 2149123
2017 Down-regulation of miR-124 target protein SCP-1 inhibits neuroglioma cell migration. European review for medical and pharmacological sciences 7 28272711
2014 A study of substrate specificity for a CTD phosphatase, SCP1, by proteomic screening of binding partners. Biochemical and biophysical research communications 7 24769477
2014 In vivo putative O-GlcNAcylation of human SCP1 and evidence for possible role of its N-terminal disordered structure. BMB reports 6 25081999
2000 A complex insertion sequence cluster at a point of interaction between the linear plasmid SCP1 and the linear chromosome of Streptomyces coelicolor A3(2). Journal of bacteriology 6 10809688
2024 Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs. PloS one 5 39208330
2018 Development of a Substrate Identification Method for Human Scp1 Phosphatase Using Phosphorylation Mimic Phage Display. Protein and peptide letters 4 29210629
2013 Recombinational cloning of the antibiotic biosynthetic gene clusters in linear plasmid SCP1 of Streptomyces coelicolor A3(2). FEMS microbiology letters 4 23710588
2007 Identification of essential genes for linear replication of an SCP1 composite plasmid. FEMS microbiology letters 4 17326804
2013 Three functional replication origins of the linear and artificially circularized plasmid SCP1 of Streptomyces coelicolor. Microbiology (Reading, England) 3 23912938
2018 Amphioxus SYCP1: a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster. Development genes and evolution 2 29297095
2014 Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein). Biochemical and biophysical research communications 2 24751520
2002 [CG17604 gene from Drosophila melanogaster--possible functional homolog of the yeast ZIP1 and SCP1 (SYCP1) mammalian genes, coding for synaptonemal complex proteins]. Genetika 2 11852789
1991 Suppressor cells for antibody production in vivo, induced by bursa cell injection into agammaglobulinemic chickens, belong to A CT4-, CT8+, TCRI- subset of T cells. Developmental and comparative immunology 2 1828774
1986 SCP1-dependent Weigle activation of the VP5 phage in Streptomyces coelicolor A3(2). Mutation research 2 3785276
2025 Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish. PLoS genetics 1 40911633
2014 Over-expression in E. coli and purification of functional full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein). Protein expression and purification 1 24925644
2007 [Expression of cancer-testis antigen SCP-1 mRNA in human nasopharyngeal carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 1 17608150
2024 Identification of Inhibitors of the Disease-Associated Protein Phosphatase Scp1 Using Antibody Mimetic Molecules. International journal of molecular sciences 0 38612548
1988 Triparental crosses in Streptomyces coelicolor A3(2) as a means of demonstrating the de-repression of SCP1 plasmid conjugative functions. Microbiologica 0 3352526