Affinage

SUZ12

Polycomb protein SUZ12 · UniProt Q15022

Length
739 aa
Mass
83.1 kDa
Annotated
2026-06-10
100 papers in source corpus 27 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SUZ12 is an essential non-catalytic core subunit of Polycomb Repressive Complex 2 (PRC2) that is required for the H3K27 histone methyltransferase activity of EZH2 and for the structural integrity of the complex; with EZH2 and EED it constitutes the minimal active enzyme, and its loss causes genome-wide collapse of H3K27me2/me3 and derepression of Hox and other developmental genes both in cells and in mouse embryos (PMID:15225548, PMID:15385962, PMID:20150217). SUZ12 not only enables catalysis but also specifies where PRC2 acts: it directs de novo establishment of the genomic H3K27 methylation pattern in PRC2-null cells, and through two structural platforms—a non-canonical C2 domain and a VEFS domain that interfaces with the EZH2 ortholog—it recruits mutually exclusive accessory subunits (AEBP2, Jarid2/EPOP, PCL/PHF19 proteins) that govern chromatin association and the bulk of PRC2's chromatin residence time (PMID:29483650, PMID:29499137, PMID:29891558, PMID:24100017). Its catalytic output is further tuned by post-translational control: CK2-mediated phosphorylation at S583 engages a stimulation loop with the SET domain to stabilize the active site and enhance SAM and nucleosome binding, while PLK1-driven phosphorylation and USP3-regulated deubiquitination control SUZ12 protein levels through the ubiquitin-proteasome system (PMID:36351927, PMID:25855382, PMID:31234902). Through this repressive program SUZ12 is required in vivo for embryogenesis, ES cell differentiation, hematopoietic stem cell maintenance, and the pacing of neural developmental timing, with partial loss producing dose-dependent phenotypes such as enhanced HSC self-renewal and accelerated neural fate acquisition (PMID:17339329, PMID:26036803, PMID:40897805). Oncogenic t(7;17) JAZF1-SUZ12 fusion proteins destabilize EZH2 and EED, reduce H3K27me3 at target loci, and fail to rescue differentiation, linking PRC2 disruption to endometrial stromal tumorigenesis (PMID:27845897).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2001 High

    Established SUZ12's founding biological role: the Drosophila ortholog Su(z)12 was shown to be a Polycomb group gene needed throughout development to maintain HOX gene repression, framing SUZ12 as a heritable transcriptional silencer.

    Evidence Drosophila loss-of-function genetics, homeotic transformation phenotyping and PEV suppression assays

    PMID:11546753

    Open questions at the time
    • Molecular mechanism of silencing not defined
    • No biochemical link to a histone-modifying complex yet
  2. 2004 High

    Defined SUZ12 as a required core subunit of PRC2 by showing it is essential both for EZH2 methyltransferase activity and for complex stability, converting the genetic Polycomb phenotype into a biochemical mechanism.

    Evidence In vitro HMTase reconstitution with defined subunits, shRNA knockdown, ChIP and Western blot in human cells; parallel Suz12 knockout mouse with in vivo H3K27me loss and proliferation defects

    PMID:15225548 PMID:15385962

    Open questions at the time
    • Structural basis of SUZ12-EZH2 interface not resolved
    • How SUZ12 is targeted to specific loci unknown
  3. 2006 Medium

    Mapped SUZ12 genome occupancy and showed cell-type-specific targeting, raising the question of how PRC2 is recruited to particular promoters.

    Evidence ChIP-chip across multiple human and mouse cell lines, with OCT4 co-occupancy at differentiation genes

    PMID:16751344

    Open questions at the time
    • Recruitment factors inferred from co-occupancy, not demonstrated functionally
    • No perturbation of OCT4 to test recruitment
  4. 2007 High

    Connected SUZ12/PRC2 to developmental gene regulation by showing Suz12 is required for proper ES cell differentiation and dynamic recruitment during lineage commitment.

    Evidence Suz12-/- mESC lines, ChIP, gene expression analysis; additional studies linking SUZ12 to RARE elements and to H3K9me3/HP1alpha regulation

    PMID:17339329 PMID:17406994 PMID:17663992

    Open questions at the time
    • EZH2-independent H3K9me3 effects mechanistically unexplained
    • Direct vs indirect effects on differentiation genes not fully separated
  5. 2010 High

    Quantified the chromatin consequences of SUZ12 loss, revealing an antagonistic H3K27 methyl/acetyl switch that explains how PRC2 loss flips chromatin from repressed to active.

    Evidence SILAC quantitative mass spectrometry of histone PTMs in Suz12-/- mESCs

    PMID:20150217

    Open questions at the time
    • Identity of the antagonizing acetyltransferase not defined
    • Whether the switch is causal or consequence of derepression unresolved
  6. 2013 High

    Dissected SUZ12 domain architecture, separating the VEFS subdomain (required for EZH2 assembly and HMTase stimulation) from the zinc finger (dispensable in vitro but needed for genomic targeting in vivo).

    Evidence Recombinant PRC2 reconstitution with VEFS mutants, in vitro HMTase assays, Drosophila genetic rescue and ChIP

    PMID:24100017

    Open questions at the time
    • Atomic structure of the interface not yet available
    • How the ZnF directs genomic targeting unknown
  7. 2015 Medium

    Identified post-translational and contextual regulators of SUZ12 levels and revealed non-canonical activities, expanding its role beyond constitutive H3K27 methylation.

    Evidence Co-IP and degradation assays for PLK1-driven phosphorylation/ubiquitination (HOTAIR-enhanced); Co-IP/ChIP for TFIIIC interaction at Pol III genes; in vitro RNA-binding assays of purified PRC2 subunits

    PMID:25855382 PMID:26038315 PMID:26177152

    Open questions at the time
    • RNA-binding specificity described as cryptic and uncharacterized
    • PLK1 phospho-sites and physiological context limited to single systems
  8. 2015 High

    Demonstrated a stage- and dose-dependent in vivo requirement for SUZ12 in blood development, showing PRC2 dosage tunes stem cell self-renewal versus differentiation.

    Evidence Hematopoietic-specific conditional Suz12 knockout, flow cytometry, colony and bone marrow transplantation assays

    PMID:26036803

    Open questions at the time
    • Direct target genes underlying HSC phenotypes not pinpointed
    • Mechanism of dose-dependent self-renewal enhancement unresolved
  9. 2018 High

    Resolved how SUZ12 both specifies PRC2 targeting and organizes the complex, showing SUZ12 alone directs de novo H3K27 methylation patterns and provides two structural platforms for mutually exclusive accessory subunits that drive chromatin binding.

    Evidence PRC2-subunit re-expression in PRC2-knockout mESCs with ChIP-seq; crystal structures of Suz12-Rbbp4-Jarid2-Aebp2 with competition/nucleosome binding assays; endogenous HaloTag single-particle tracking with separation-of-function mutants

    PMID:29483650 PMID:29499137 PMID:29891558

    Open questions at the time
    • How accessory-subunit choice is determined in different cell types unclear
    • Sequence/chromatin features read by SUZ12 platforms not fully defined
  10. 2022 High

    Established a phosphorylation-based catalytic switch, showing CK2 phosphorylation of SUZ12 S583 stabilizes the EZH2 active site and SAM-binding pocket to promote PRC2 catalysis and H3K27me3 deposition.

    Evidence Crystal structure with phosphomimetic/phosphodead mutants, in vitro kinase assays, nucleosome binding, and ChIP-seq in mESCs

    PMID:36351927

    Open questions at the time
    • Signals upstream of CK2 that gate this modification unknown
    • Crosstalk with PLK1-driven degradation not integrated
  11. 2025 High

    Identified SUZ12 as a tunable regulator of developmental timing, where its loss accelerates neural fate by shifting the H3K4me3/H3K27me3 balance at bivalent promoters.

    Evidence Genome-wide CRISPR-Cas9 screen, directed hESC neural differentiation, H3K4me3/H3K27me3 ChIP-seq, pharmacological loss-of-function

    PMID:40897805

    Open questions at the time
    • Mechanistic basis of synergy with Menin not resolved
    • Whether timing control generalizes beyond neural lineage untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SUZ12-directed PRC2 reads genomic features to select its de novo targets in a cell-type-specific manner, and how the multiple SUZ12 post-translational inputs (CK2, PLK1, USP3) are coordinated in vivo, remain unresolved.
  • No unifying model linking SUZ12 modifications to target selection
  • Sequence determinants of de novo PRC2 nucleation undefined
  • Cell-type logic of accessory subunit usage unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0003677 DNA binding 3 GO:0098772 molecular function regulator activity 3 GO:0140110 transcription regulator activity 3 GO:0042393 histone binding 1
Localization
GO:0000228 nuclear chromosome 4 GO:0005634 nucleus 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-4839726 Chromatin organization 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1643685 Disease 2
Partners
AEBP2EEDEZH2JARID2PHF19RBBP4TFIIICUXT
Complex memberships
PRC2

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 SUZ12 is required for both the histone methyltransferase (HMTase) activity and stability of PRC2/3 complexes. The minimum components required for HMTase activity are EZH2, EED, and SUZ12, while AEBP2 is required for optimal activity. SUZ12 knockdown results in genome-wide loss of H3-K27 methylation and upregulation of Hox genes. ChIP identified a SUZ12 binding site ~4 kb upstream of HoxA9 transcription initiation site. In vitro HMTase reconstitution assay, stable shRNA knockdown cell line, ChIP, Western blot Molecular cell High 15225548
2004 SUZ12 is essential for EZH2 histone methyltransferase activity and for the stability of PRC2/3 complexes in mouse embryos, tissue culture cells, and in vitro. Suz12-deficient mouse embryos show specific loss of di- and trimethylated H3K27, demonstrating that Suz12 is required for EZH2 activity in vivo. SUZ12 is also required for cell proliferation in tissue culture. Suz12 knockout mouse model, in vitro HMTase activity assays, Western blot for H3K27me marks, cell proliferation assays The EMBO journal High 15385962
2007 Suz12 is required for proper ES cell differentiation; Suz12-/- ES cells display global loss of H3K27me3, higher expression of differentiation-specific genes, and are impaired in establishing specific expression programs during differentiation. PcG proteins are actively recruited to several genes during ES cell differentiation to increase H3K27me3 levels. Suz12-/- mouse ES cell lines, ChIP, gene expression analysis Molecular and cellular biology High 17339329
2001 Drosophila Su(z)12 is a Polycomb group gene required throughout development to maintain repression of HOX genes; Su(z)12 mutations cause strong homeotic transformations and suppress position-effect variegation (PEV), suggesting a role in heterochromatin-mediated repression. Su(z)12 is also required for germ cell development. Drosophila genetic loss-of-function mutant analysis, homeotic transformation phenotyping, PEV suppression assay Development (Cambridge, England) High 11546753
2006 Suz12 binds to silenced regions of the genome in a cell-type-specific manner as part of PRC2/3/4 complexes. Target promoters are cell-type specific; PRC2 complexes can be localized to discrete binding sites or spread through large genomic regions. Some Suz12 target genes are co-bound by OCT4 in embryonal cells, suggesting OCT4 recruits PRC complexes to differentiation-promoting genes. ChIP-chip (promoter and tiling arrays) in five human and mouse cell lines Genome research Medium 16751344
2007 SUZ12 associates with retinoic acid response elements (RAREs) of Hoxa1, RARbeta2, and Cyp26A1 in embryonal carcinoma cells; this association is attenuated by RA treatment and restored upon RA removal, correlating with changes in H3K27me3 levels. RARγ is required for deposition of SUZ12 at target gene RAREs and both RARγ and Suz12 exist in a multi-protein complex in the absence of ligand in ES cells. ChIP assay, co-immunoprecipitation Journal of molecular biology Medium 17663992 20857416
2018 H3K27 methylation patterns can be accurately established de novo by SUZ12-directed PRC2 without pre-existing H3K27 methylation marks. Re-expression of PRC2 subunits in PRC2-knockout mESCs that have lost all H3K27 methylation restores correct methylation patterns. Specification of the genomic PRC2 binding pattern is specifically dependent on the PRC2 core subunit SUZ12. PRC2 subunit re-expression in PRC2-knockout mESCs, ChIP-seq, H3K27 methylation profiling Nature structural & molecular biology High 29483650
2018 Crystal structures of a 120 kDa Suz12-Rbbp4-Jarid2-Aebp2 heterotetrameric complex and an inactive Suz12-Rbbp4 binary complex reveal that Suz12 contains two unique structural platforms defining distinct classes of PRC2 for chromatin binding. Aebp2 and Phf19 compete for binding of a non-canonical C2 domain of Suz12; Jarid2 and EPOP occupy an overlapping Suz12 surface required for chromatin association. Suz12 and Aebp2 progressively block histone H3K4 binding to Rbbp4. X-ray crystallography, nucleosome binding assays, competition binding assays Molecular cell High 29499137
2018 Live-cell imaging and single-particle tracking of endogenously HaloTag-tagged EZH2 and SUZ12 in human cancer cells shows ~80% of PRC2 rapidly diffuses through the nucleus while ~20% is chromatin-bound. Separation-of-function mutants of SUZ12 that cannot bind accessory proteins (AEBP2 and PCL homolog proteins) have reduced chromatin residence time, revealing that these accessory proteins make a major contribution to PRC2 chromatin binding. CRISPR-mediated endogenous HaloTag insertion, single-particle tracking, live-cell imaging Genes & development High 29891558
2013 Functional dissection of the Drosophila SU(Z)12 subunit identifies distinct VEFS subdomain elements required for assembly with E(Z) and for stimulation of histone methyltransferase activity. The SU(Z)12 zinc finger (ZnF) is not needed for methyltransferase activity in vitro but is required in vivo for proper PRC2 binding to genomic targets. Recombinant PRC2 reconstitution with VEFS domain mutants, in vitro HMTase assay, genetic rescue assay, ChIP Molecular and cellular biology High 24100017
2007 SUZ12 regulates histone H3 lysine 9 methylation independently of EZH2 in differentiated cells. Knockdown of SUZ12 in human cells reduces both H3K27me3 and H3K9me3 and alters HP1α distribution, whereas EZH2 knockdown causes loss of H3K27me3 but not H3K9me3. shRNA knockdown, Western blot for histone marks, immunofluorescence for HP1α distribution Chromosome research Medium 17406994
2007 Drosophila SU(Z)12 binds ~90 specific chromosomal sites co-localizing with E(z) and other PRC2 components on polytene chromosomes. Overexpression of SU(Z)12 in somatic clones results in higher H3K27me3 levels, indicating SU(Z)12 is rate-limiting for PRC2 enzymatic activity in vivo. Polytene chromosome immunostaining, immunostaining of somatic clones Molecular genetics and genomics Medium 18034266
2015 PLK1 kinase induces proteasomal degradation of SUZ12 by site-specific phosphorylation. PLK1-dependent ubiquitination of SUZ12 is enhanced by the lncRNA HOTAIR. This phosphorylation-mediated degradation of SUZ12 leads to global changes in histone modifications in HBV X protein-expressing cells. Co-immunoprecipitation, site-specific phosphorylation assays, proteasome inhibitor experiments, Western blot Cancer research Medium 25855382
2022 CK2 (casein kinase 2) phosphorylates SUZ12 at residue S583. Crystal structure shows the flexible phosphorylation-dependent stimulation loop harboring S583 becomes engaged with the catalytic SET domain through a phosphoserine-centered interaction network, stabilizing the enzyme active site and SAM-binding pocket. CK2-mediated S583 phosphorylation promotes PRC2 catalysis by enhancing binding to SAM and nucleosomal substrates, facilitates reporter gene repression, and loss of S583 phosphorylation impedes PRC2 recruitment and H3K27me3 deposition in mESCs. Crystal structure determination, in vitro kinase assay, CK2 inhibition, S583 phosphorylation mutants, nucleosome binding assay, ChIP-seq in mESCs Nature communications High 36351927
2006 SUZ12 interacts with the WD-repeat protein MEP50 in vitro and in vivo. MEP50 selectively binds histone H2A among core histones and mediates transcriptional repression of PRMT5. Co-immunoprecipitation (in vitro and in vivo), histone binding assay Biochemical and biophysical research communications Low 16712789
2015 EZH2 and SUZ12 directly bind to RNAs with a general preference for longer RNAs. Individual PRC2 components purified from human cells have cryptic RNA-binding activity. Purification of individual PRC2 components from human cells followed by RNA-binding assays RNA biology Low 26177152
2016 The EZH1-SUZ12 complex positively regulates transcription of NF-κB target genes through interaction with UXT. UXT specifically interacts with EZH1 and SUZ12 but not EED. EZH1 and SUZ12 regulate the recruitment of p65 and RNA Pol II to NF-κB target genes without affecting H3K27 methylation at those loci. Co-immunoprecipitation, shRNA knockdown, ChIP-seq, luciferase reporter assay Journal of cell science Medium 27127229
2015 SUZ12 is required for EZH2-mediated repression of RNA Pol III-transcribed non-translated RNA genes (tRNA, 5S rRNA, 7SL RNA). EZH2 and H3K27me3 co-occupy promoters of these genes; SUZ12 interacts with the TFIIIC complex and its knockdown decreases EZH2 occupancy and H3K27me3 at Pol III target gene promoters. ChIP, Co-IP, shRNA knockdown, qRT-PCR Nucleic acids research Medium 26038315
2017 The JAZF1-SUZ12 fusion protein destabilizes PRC2 components EZH2 and EED, resulting in decreased histone methyltransferase activity (confirmed by in vitro studies using reconstituted PRC2 and nucleosome array substrates), decreased binding affinity of PRC2 to target chromatin loci, and reduced H3K27me3 in ESS tissue samples with t(7;17). Re-expression of wild-type SUZ12 in Suz12-/- ES cells rescued neuronal differentiation, whereas the fusion protein failed to restore this function. In vitro reconstituted PRC2 HMTase assay with nucleosome arrays, Co-IP, ChIP, Western blot for H3K27me3, ES cell differentiation rescue assay Oncotarget High 27845897
2019 USP3 (ubiquitin-specific protease 3) interacts with and stabilizes SUZ12 via deubiquitination. SUZ12 knockdown inhibits USP3-induced cell migration, invasion, and EMT in gastric cancer cells. Co-immunoprecipitation, deubiquitination assay, siRNA knockdown, migration and invasion assays Journal of experimental & clinical cancer research Medium 31234902
2015 Conditional deletion of Suz12 in hematopoietic cells results in failure of hematopoiesis and loss of hematopoietic stem cell (HSC) maintenance in both embryo and adult. Partial loss of PRC2 (via heterozygous Suz12 deletion) enhances HSC self-renewal. Suz12 is required for lymphoid development but is dispensable for granulocytic, monocytic, and megakaryocytic development. Conditional Suz12 knockout mouse model (hematopoietic-specific Cre), flow cytometry, colony assays, bone marrow transplantation Blood High 26036803
2010 SUZ12 loss in Suz12-deficient mESCs leads to dramatic reduction of H3K27me2 and H3K27me3 and a compensatory increase of H3K27ac, uncovering an antagonistic methyl/acetyl switch at H3K27. Reduction in H3K27 methylation is accompanied by H3K36 acetylation and methylation changes. Quantitative mass spectrometry (SILAC + LC-MS/MS) with ETD and CID fragmentation, Suz12-/- mESCs Molecular & cellular proteomics High 20150217
2012 SUZ12 knockdown in human EOC cells decreases H3K27me3 levels and triggers apoptosis. HRK (Harakiri), a proapoptotic gene, is identified as a direct SUZ12 target gene whose upregulation mediates apoptosis induced by SUZ12 knockdown. shRNA knockdown, ChIP, Western blot, xenograft mouse model Molecular cancer research Medium 22964433
2007 In Drosophila, the JAZF1-JJAZ1 (SUZ12) fusion protein (JAZF1-JJAZ1) in human cells was shown to restore EZH2 levels and H3K27me3 that were reduced by knockdown of endogenous JJAZ1/SUZ12. Presence of the JAZF1-JJAZ1 fusion markedly inhibits apoptosis and induces above-normal proliferation rates when normal JJAZ1 is suppressed. shRNA knockdown of endogenous JJAZ1, ectopic expression of JAZF1-JJAZ1 fusion, Western blot for EZH2 and H3K27me3, apoptosis and proliferation assays Proceedings of the National Academy of Sciences of the United States of America Medium 18077430
2011 SUZ12 occupies promoters of specific genes (BAMBI, CCND2, DKK2, DLK1, EpCAM, IGFII) in untransformed hepatocytes, repressing their transcription. Suz12 knockdown or pX-mediated transformation reduces Suz12 promoter occupancy and activates these repressed target genes. ChIP, shRNA knockdown, RT-PCR in cell lines and animal models Hepatology (Baltimore, Md.) Medium 22505317
2015 Suz12 conditional deletion in hematopoietic cells results in complete failure of hematopoiesis. Partial loss enhances HSC self-renewal indicating dose-dependent PRC2 activity effects in blood development. Conditional knockout, hematopoietic progenitor assays, bone marrow transplantation Blood High 26036803
2025 Genome-wide CRISPR-Cas9 knockout screen identified SUZ12 as a modulator of developmental timing in human neural differentiation. Loss of SUZ12 accelerates PAX6 expression and cell fate acquisition during neural differentiation by shifting the balance of H3K4me3 and H3K27me3 at bivalent promoters, priming developmental genes for faster activation. SUZ12 and Menin show synergistic interaction in controlling differentiation speed. Whole-genome CRISPR-Cas9 knockout screen, directed differentiation of hESCs, ChIP-seq for H3K4me3 and H3K27me3, pharmacological loss-of-function Nature cell biology High 40897805

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. The EMBO journal 726 15385962
2004 SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Molecular cell 652 15225548
2007 The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Molecular and cellular biology 561 17339329
2014 PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nature genetics 483 25240281
2014 TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. Clinical cancer research : an official journal of the American Association for Cancer Research 369 24449823
2010 Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Molecular cell 331 20832727
2001 Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proceedings of the National Academy of Sciences of the United States of America 288 11371647
2006 Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome research 260 16751344
2018 Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2. Nature structural & molecular biology 181 29483650
2019 EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell chemical biology 167 31786184
2001 Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development (Cambridge, England) 162 11546753
2012 Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes, chromosomes & cancer 125 22489043
1995 Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA research : an international journal for rapid publication of reports on genes and genomes 124 8590280
2003 Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy. Molecular cancer therapeutics 123 12533679
2018 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Molecular cell 121 29499137
2015 PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis. Cancer research 121 25855382
2016 lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Neuron 112 28041882
2007 Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. Journal of molecular biology 112 17663992
2004 High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene. American journal of human genetics 108 15257518
2010 Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36. Molecular & cellular proteomics : MCP 107 20150217
2015 Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 103 26268246
2013 Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis. British journal of cancer 91 24169343
2004 Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. The American journal of surgical pathology 87 15043312
2015 Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis. Blood 84 26036803
2007 Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. The American journal of surgical pathology 82 17197920
2018 Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes & development 70 29891558
2009 Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors. The American journal of surgical pathology 69 19542872
2005 JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. The Journal of molecular diagnostics : JMD 67 16049311
2003 Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). Cancer genetics and cytogenetics 67 12850374
2007 High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. The American journal of surgical pathology 64 17667554
2014 Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer. Journal of cancer research and clinical oncology 63 25326896
2012 SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK. Molecular cancer research : MCR 62 22964433
2007 Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Proceedings of the National Academy of Sciences of the United States of America 62 18077430
2017 The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis. Oncotarget 54 27845897
2019 Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer. Journal of experimental & clinical cancer research : CR 53 31234902
2011 Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. Hepatology (Baltimore, Md.) 50 21480320
2022 MARCKSL1-2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b. Molecular cancer 48 35864549
2014 SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 47 24633887
2020 Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A). Circulation. Heart failure 46 31957467
2015 SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 45 25672609
2012 Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein. Hepatology (Baltimore, Md.) 45 22505317
2009 Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube. Disease models & mechanisms 43 19535498
2020 CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature communications 42 32807777
2016 JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas. Orphanet journal of rare diseases 42 26879382
2019 Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia. Blood 41 31492675
2019 LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression. Pathology, research and practice 40 31196742
2018 Novel SUZ12 mutations in Weaver-like syndrome. Clinical genetics 40 30019515
2015 Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 40 25833694
2010 Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma. The American journal of pathology 38 20558579
2013 SUZ12 depletion suppresses the proliferation of gastric cancer cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36 23735840
2007 The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 36 17406994
2016 The EZH1-SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT. Journal of cell science 32 27127229
2012 Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation. The Journal of biological chemistry 31 22843710
2021 TSC2-mutant uterine sarcomas with JAZF1-SUZ12 fusions demonstrate hybrid features of endometrial stromal sarcoma and PEComa and are responsive to mTOR inhibition. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 30 34561551
2018 TRPS1 Suppresses Breast Cancer Epithelial-mesenchymal Transition Program as a Negative Regulator of SUZ12. Translational oncology 30 29471243
2013 Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function. Molecular and cellular biology 29 24100017
2022 Loss of m6A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression. Frontiers in cardiovascular medicine 27 35295259
2011 JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma. Human pathology 27 21316079
2006 Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Biochemical and biophysical research communications 27 16712789
2019 miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12. Oncology reports 26 31115583
2010 SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes, chromosomes & cancer 26 19847889
2022 CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site. Nature communications 25 36351927
2019 Low-grade endometrial stromal sarcoma with a novel MEAF6-SUZ12 fusion. Virchows Archiv : an international journal of pathology 25 31101969
2015 Cryptic RNA-binding by PRC2 components EZH2 and SUZ12. RNA biology 25 26177152
2018 SUZ12 is a novel putative oncogene promoting tumorigenesis in head and neck squamous cell carcinoma. Journal of cellular and molecular medicine 23 29667751
2021 HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression. Aging 22 34167089
2011 RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells. Journal of cellular physiology 22 20857416
2007 Extrauterine endometrial stromal sarcoma with JAZF1/JJAZ1 fusion confirmed by RT-PCR and interphase FISH presenting as an inguinal tumor. Virchows Archiv : an international journal of pathology 22 17235569
2023 Therapeutic targeting of FUBP3 phase separation by GATA2-AS1 inhibits malate-aspartate shuttle and neuroblastoma progression via modulating SUZ12 activity. Oncogene 20 37537343
2019 The Down-Regulation of SUZ12 Accelerates the Migration and Invasion of Liver Cancer Cells via Activating ERK1/2 Pathway. Journal of Cancer 20 31031847
2015 Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells. Experimental cell research 18 26407907
2023 Imagawa-Matsumoto syndrome: SUZ12-related overgrowth disorder. Clinical genetics 17 36645289
2017 Identification of an atypical microdeletion generating the RNF135-SUZ12 chimeric gene and causing a position effect in an NF1 patient with overgrowth. Human genetics 17 28776093
2015 PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex. Nucleic acids research 17 26038315
2017 MicroRNA-105 inhibits human glioma cell malignancy by directly targeting SUZ12. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 16 28618952
2025 LncRNA-MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid-Liquid Phase Separation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 14 40285575
2020 Knockdown of lncRNA PCAI protects against cognitive decline induced by hippocampal neuroinflammation via regulating SUZ12. Life sciences 13 32247002
2018 Low-grade Endometrioid Stromal Sarcoma of the Paratestis: A Novel Report With Molecular Confirmation of JAZF1/SUZ12 Translocation. The American journal of surgical pathology 13 29394168
2021 Re-expression of miR-200s in claudin-low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes. Cancer cell international 12 33541373
2019 DNA methylation-regulated and tumor-suppressive roles of miR-487b in colorectal cancer via targeting MYC, SUZ12, and KRAS. Cancer medicine 12 30791232
2009 Characterization of the expression pattern of the PRC2 core subunit Suz12 during embryonic development of Xenopus laevis. Developmental dynamics : an official publication of the American Association of Anatomists 12 19877271
2020 suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types. Disease models & mechanisms 11 32651197
2017 Deregulated expression of microRNA-200b/c and SUZ12, a Polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells. Genes & cancer 10 28966728
2023 SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs. Journal of biochemical and molecular toxicology 9 36994588
2021 SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas. Frontiers in oncology 9 34692515
2007 In vivo analysis of Drosophila SU(Z)12 function. Molecular genetics and genomics : MGG 9 18034266
2021 Novel MEAF6-SUZ12 fusion in ossifying fibromyxoid tumor with unusual features. Genes, chromosomes & cancer 8 33840146
2019 JAZF1-SUZ12 endometrial stromal sarcoma forming subserosal masses with extraordinary uptake of fluorodeoxyglucose on positron emission tomography: a case report. Diagnostic pathology 8 31615558
2025 LINC-PINT suppresses the progression of acute myeloid leukemia via miR-767-5p/SUZ12-mediated JAK/STAT signaling pathway. Cytokine 7 39978301
2022 SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels. Journal of leukocyte biology 7 34990019
2021 RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. PLoS genetics 7 34928964
2024 Upregulation of Enhancer of Zeste Homolog 2 (EZH2) with Associated pERK Co-Expression and PRC2 Complex Protein SUZ12 Correlation in Adult T-Cell Leukemia/Lymphoma. Cancers 6 38339397
2024 SUZ12-Increased NRF2 Alleviates Cardiac Ischemia/Reperfusion Injury by Regulating Apoptosis, Inflammation, and Ferroptosis. Cardiovascular toxicology 6 39729180
2023 Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced Dysfunction Through Upregulating SUZ12 Expression to Activate Wnt/β-catenin Signaling Pathway. International heart journal 6 37967992
2022 Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12. iScience 6 35800781
2025 Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing. Nature cell biology 5 40897805
2023 An investigation of the etiology and follow-up findings in 35 children with overgrowth syndromes, including biallelic SUZ12 variant. American journal of medical genetics. Part A 5 36919607
2016 [Endometrial stromal sarcoma: morphologic features and detection of JAZF1-SUZ12 and YWHAE FAM22 fusion genes]. Zhonghua bing li xue za zhi = Chinese journal of pathology 5 27142911
2014 Colonic low-grade endometrial stromal sarcoma and orthotopic endometrial stromal tumor with limited infiltration sharing the JAZF1-SUZ12 gene fusion. Pathology international 5 24750188
2010 Absence of the JAZF1/SUZ12 chimeric transcript in the immortalized non-neoplastic endometrial stromal cell line T HESCs. Oncology letters 5 22870092

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