Affinage

STC1

Stanniocalcin-1 · UniProt P52823

Length
247 aa
Mass
27.6 kDa
Annotated
2026-06-10
100 papers in source corpus 22 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STC1 is a secreted glycoprotein that acts at the cell surface and on mitochondria to modulate energy metabolism, calcium handling, and intercellular signaling, with prominent roles in the tumor microenvironment (PMID:17092635, PMID:22146344, PMID:23243022). Through high-affinity cell-surface receptors it engages inhibitory G-protein signaling to suppress cAMP and dampens FSH-stimulated steroidogenesis in granulosa cells, acting downstream of adenylate cyclase (PMID:15131261, PMID:25591908). On isolated mitochondria STC1 uncouples oxidative phosphorylation—raising respiration while lowering ADP:O ratios and increasing Ca2+ uptake in a nucleotide-sensitive manner (PMID:17092635)—and in cells it drives this effect by upregulating UCP2, thereby lowering ROS and shifting metabolism toward glycolysis (PMID:22146344). In cancer, stromal- and CAF-derived STC1 promotes metastasis downstream of PDGF receptor signaling (PMID:23243022), and within tumor cells STC1 acts as a protein-protein competitor and scaffold: it competes with YAP for βPIX binding to drive YAP nuclear translocation and CCL2/VEGFA signaling (PMID:38768671), sequesters calreticulin in mitochondria to block the surface 'eat-me' signal and enable immune evasion (a function stabilized when A20 blocks GSK3β-mediated phosphorylation at Thr86) (PMID:37607946), and shapes macrophage differentiation by sequestering GRP94 (PMID:32579928). STC1's own expression is set transcriptionally and post-transcriptionally, including CAPG/PRMT5 competition at its promoter and m6A-dependent control of upstream regulators (PMID:29721098, PMID:32859993). A mechanistically distinct activity is seen in fission yeast, where the Stc1 ortholog bridges the RNAi effector Ago1 to the CLRC histone methyltransferase complex to couple RNAi to H3K9 methylation and heterochromatin formation (PMID:20211136, PMID:23613586).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2004 Medium

    Established that STC1 is a secreted paracrine factor acting through specific cell-surface receptors, answering whether it signals on target endocrine cells; it suppresses FSH-stimulated steroidogenesis downstream of adenylate cyclase.

    Evidence Recombinant STC1 treatment of primary rat granulosa cells with radioligand receptor binding and steroid/cAMP readouts

    PMID:15131261

    Open questions at the time
    • Receptor identity not molecularly defined
    • Signaling step downstream of adenylate cyclase not resolved
  2. 2006 Medium

    Defined a direct mitochondrial action for STC1, showing it uncouples oxidative phosphorylation and enhances Ca2+ uptake in a nucleotide-regulated manner, locating part of its function at the organelle.

    Evidence Respiration and ADP:O assays plus 45Ca uptake and nucleotide-competition receptor binding on isolated rat mitochondria

    PMID:17092635

    Open questions at the time
    • Molecular target on/in mitochondria not identified
    • Link between surface receptor binding and mitochondrial entry unresolved
  3. 2010 High

    Resolved how RNAi is coupled to heterochromatin in fission yeast by showing the Stc1 ortholog physically bridges Ago1 and the CLRC complex, with tethering sufficient to silence.

    Evidence Co-IP, genetic epistasis, tethering assay, and H3K9me ChIP in fission yeast

    PMID:20211136

    Open questions at the time
    • Relationship of this nuclear chromatin role to mammalian secreted STC1 unclear
    • Does not address mammalian function
  4. 2011 Medium

    Connected STC1's mitochondrial uncoupling activity to a cellular effector, showing UCP2 upregulation mediates ROS reduction and a glycolytic shift that promotes cancer cell survival.

    Evidence UCP2 shRNA knockdown with recombinant STC1 rescue, ROS, membrane potential, and lactate assays in A549 cells

    PMID:22146344

    Open questions at the time
    • Mechanism linking STC1 receptor engagement to UCP2 transcription not defined
  5. 2012 Medium

    Demonstrated a stromal pro-metastatic role, placing STC1 downstream of PDGF receptor signaling in cancer-associated fibroblasts that drive tumor cell intravasation.

    Evidence Coculture invasion assays and STC1-deficient fibroblasts in an orthotopic mouse model

    PMID:23243022

    Open questions at the time
    • Receptor on tumor cells mediating the effect not identified
    • Direct STC1 effector in invasion unresolved
  6. 2013 High

    Provided the structural basis for the Stc1 bridge, showing an unusual N-terminal tandem zinc finger binds Ago1 while the C-terminus binds CLRC.

    Evidence NMR/structural analysis with deletion/mutagenesis and Co-IP in fission yeast

    PMID:23613586

    Open questions at the time
    • Structure pertains to the yeast ortholog, not mammalian STC1
  7. 2015 Low

    Began to define STC1's proximal signaling, indicating it acts through inhibitory G-protein to suppress cAMP in a receptor-specific manner.

    Evidence cAMP accumulation assays in calcitonin-receptor- vs CALCRL/RAMP1-transfected HEK293 cells and receptor immunofluorescence

    PMID:25591908

    Open questions at the time
    • Cell-based assay in transfected cells without direct STC1-receptor binding demonstration
    • Endogenous receptor not established
  8. 2018 Medium

    Explained how STC1 transcription is set epigenetically, showing CAPG displaces the repressor PRMT5 at the STC1 promoter to lower H4R3 methylation and boost expression.

    Evidence ChIP, luciferase reporter, Co-IP, HMT assay, and xenograft in breast cancer

    PMID:29721098

    Open questions at the time
    • Generality across tissues not tested
  9. 2020 Medium

    Extended STC1 regulation to the m6A/RNA axis, showing AURKA-stabilized METTL14 promotes m6A of DROSHA, which with β-Catenin transactivates STC1 to drive stemness.

    Evidence Co-IP, m6A analysis, RNA stability, ubiquitylation, and mutant rescue in breast cancer stem-like cells

    PMID:32859993

    Open questions at the time
    • Direct STC1 contribution to stemness phenotype only inferred from upstream regulators
  10. 2020 Medium

    Identified a sequestration mechanism by which fibroblast STC1 suppresses macrophage maturation, proposing GRP94 sequestration to limit autocrine differentiation signals.

    Evidence Stc1 knockout mouse lung tumor models with macrophage differentiation assays and TGF-β1 measurement

    PMID:32579928

    Open questions at the time
    • GRP94 sequestration inferred rather than directly demonstrated biochemically
  11. 2023 Medium

    Defined a calreticulin-sequestration mechanism of immune evasion, with STC1 retaining CRT in mitochondria, and a phospho-regulatory node (A20→GSK3β→Thr86) controlling STC1 stability.

    Evidence Co-IP, phospho-STC1(Thr86) Western blots, cell-surface CRT assays, and in vivo colorectal cancer models

    PMID:37607946

    Open questions at the time
    • How STC1 enters/retains CRT in mitochondria mechanistically unresolved
  12. 2024 Medium

    Revealed STC1 as a competitive scaffold, displacing YAP from βPIX to drive YAP nuclear activation, CCL2/VEGFA signaling, and a pro-metastatic feedback loop with PD-L1 induction.

    Evidence MS, Co-IP (STC1–βPIX, YAP–βPIX), CCL2 reporter/ChIP, and in vivo lung metastasis model in melanoma

    PMID:38768671

    Open questions at the time
    • Whether secreted vs intracellular STC1 mediates βPIX competition not clarified

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity of the mammalian STC1 cell-surface receptor and the molecular link between extracellular receptor engagement and its intracellular/mitochondrial activities remain unresolved.
  • Receptor not cloned
  • Mechanism of mitochondrial localization of a secreted protein undefined
  • Reconciliation of yeast chromatin role with mammalian secreted roles absent

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0140313 molecular sequestering activity 3 GO:0060089 molecular transducer activity 2
Localization
GO:0005576 extracellular region 3 GO:0005634 nucleus 2 GO:0005739 mitochondrion 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-1430728 Metabolism 2 R-HSA-168256 Immune System 2 R-HSA-4839726 Chromatin organization 2
Partners
AGO1ARHGEF7CRTHSP90B1NOTCH1YAP1

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 Fission yeast Stc1 (a LIM domain protein) acts as a molecular bridge coupling RNAi to heterochromatin formation: it physically interacts with the RNAi effector Ago1 (via its N-terminal tandem zinc finger domain) and with the chromatin-modifying CLRC complex (via its non-conserved C-terminal region), thereby recruiting CLRC to RITS-bound centromeric transcripts and promoting H3K9 methylation. Tethering Stc1 to a euchromatic locus is sufficient to induce silencing independently of RNAi. Co-immunoprecipitation, genetic epistasis, tethering assay, ChIP for H3K9me, loss-of-function analysis in fission yeast Cell High 20211136
2013 Structural analysis of fission yeast Stc1 revealed that its conserved N-terminal region forms an unusual tandem zinc finger domain (with similarities to LIM domains but lacking preferred relative orientation of the two zinc fingers) that mediates binding to Ago1, while the non-conserved C-terminal region mediates association with CLRC. NMR/structural analysis combined with in vivo functional validation (deletion/mutagenesis analysis, Co-IP) Proceedings of the National Academy of Sciences of the United States of America High 23613586
2004 Recombinant N-glycosylated STC1 protein specifically suppresses FSH-stimulated progesterone biosynthesis (including CYP11A transcripts and LH receptor induction) in rat granulosa cells while having minimal effect on estradiol and cAMP production; radiolabeled STC1 shows high-affinity specific receptor binding on granulosa cells, and STC1 acts downstream of adenylate cyclase, suggesting a follicular paracrine system in which theca-derived STC1 dampens granulosa cell differentiation. Recombinant protein treatment of primary granulosa cells, radioligand receptor binding assay, RT-PCR for CYP11A, RIA for steroid hormones Molecular endocrinology (Baltimore, Md.) Medium 15131261
2006 STC1 uncouples oxidative phosphorylation in intact mitochondria isolated from rat muscle and liver: exposure to 500 nM recombinant human STC1 increases respiration rate, significantly reduces ADP:O ratios, and enhances mitochondrial 45Ca uptake. These respiratory effects are attenuated or abolished by nucleotide triphosphates (ATP, GTP at 5 mM) through a four-fold decrease in receptor binding affinity. Mitochondrial respiration assay (oxygen consumption), ADP:O ratio measurement, 45Ca uptake assay, radioligand receptor binding assay with nucleotide competition Molecular and cellular endocrinology Medium 17092635
2011 MSC-derived STC1 promotes survival of lung cancer (A549) cells by upregulating uncoupling protein 2 (UCP2), which uncouples oxidative phosphorylation, reduces intracellular ROS, decreases mitochondrial membrane potential, and shifts metabolism toward glycolysis (increased lactate production). Knockdown of UCP2 abolishes the protective effects of both MSC conditioned medium and recombinant STC1. shRNA knockdown of UCP2, recombinant STC1 treatment, ROS measurement, mitochondrial membrane potential assay, lactate production assay Molecular therapy : the journal of the American Society of Gene Therapy Medium 22146344
2012 PDGF-stimulated cancer-associated fibroblasts increase migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner; in an orthotopic mouse model, STC1-deficient fibroblasts produce tumors with reduced tumor cell intravasation and fewer/smaller distant metastases, identifying STC1 as a mediator of PDGF receptor-driven metastasis. Co-culture invasion/migration assay, STC1-deficient fibroblasts (genetic loss-of-function), orthotopic mouse model with intravasation quantification Cancer research Medium 23243022
2018 CAPG competes with the transcriptional repressor PRMT5 for binding to the STC1 promoter; when CAPG displaces PRMT5, histone H4R3 methylation at the STC1 promoter is reduced, leading to enhanced STC1 transcription and increased breast cancer cell metastasis. Chromatin immunoprecipitation (ChIP), luciferase reporter assay, Co-IP, MS/MS, histone methyltransferase assay, xenograft model Theranostics Medium 29721098
2020 DROSHA interacts with β-Catenin to transactivate STC1 in an RNA cleavage-independent manner in breast cancer stem-like cells (BCSCs), promoting stemness. AURKA stabilizes METTL14 (by inhibiting its ubiquitylation/degradation) to promote m6A methylation of DROSHA mRNA, enhancing its stability; AURKA also directly binds the DROSHA transcript to strengthen IGF2BP2 binding and stabilization of m6A-modified DROSHA. Co-IP (DROSHA–β-Catenin interaction), m6A methylation analysis, ubiquitylation assay, RNA stability assay, luciferase reporter, m6A-deficient mutant rescue experiments Cell research Medium 32859993
2019 STC1 ameliorates renal injury in diabetic nephropathy by inhibiting BNIP3 expression through activation of the AMPK/SIRT3 pathway in db/db mice and high-glucose-treated BUMPT cells. In vivo db/db mouse model, in vitro high-glucose cell model, Western blotting for AMPK/SIRT3/BNIP3 pathway components, siRNA knockdown Laboratory investigation; a journal of technical methods and pathology Low 30683904
2016 Elevated STC1 increases invasiveness of triple-negative breast cancer cells through activation of the JNK/c-Jun signaling pathway, leading to increased MMP-9 expression; JNK inhibitor SP600125 suppresses both STC1-induced MMP-9 expression and cell invasion. Recombinant STC1 treatment, siRNA knockdown, Western blotting for phospho-JNK/c-Jun, MMP-9 expression, Transwell invasion assay Oncology reports Low 27459971
2017 STC1 regulates glioblastoma migration and invasion via the TGF-β/SMAD4 signaling pathway: STC1 knockdown reduces SMAD2/3 and SMAD4 protein levels, and SMAD4 expression is suppressed by miR-34a (whose expression is also decreased by STC1 knockdown), with luciferase assay confirming SMAD4 3'UTR as miR-34a target. shRNA knockdown, lentiviral overexpression, Western blotting, luciferase 3'UTR reporter assay, EdU/Transwell assays Molecular medicine reports Low 31432189
2021 STC1 inhibits airway smooth muscle (ASM) contraction and airway hyperresponsiveness by blocking store-operated Ca2+ entry (SOCE) through suppression of stromal interaction molecule 1 (STIM1), thereby inhibiting Ca2+-dependent myosin light chain (MLC) phosphorylation. IL-13 suppresses STC1 release from bronchial epithelial cells, whereas recombinant human STC1 reduces AHR and inflammation in OVA-challenged mice. Recombinant human STC1 (rhSTC1) treatment ex vivo and in vivo (intranasal), Ca2+ influx assay (SOCE measurement), STIM1/MLC phosphorylation Western blotting, mouse AHR model Allergy Medium 33378582
2015 STC1 signals through inhibitory G-protein to modulate cAMP: STC1 inhibits forskolin-stimulated cAMP accumulation in HEK293 cells transfected with calcitonin receptor (CTR) but not in CALCRL/RAMP1-transfected HEK293 cells, indicating STC1's inhibitory action is specific to CTR and not CGRP receptor. STC1 also modifies plasma membrane spatial distribution of CALCRL/RAMP1 complex in pre-osteoblasts. cAMP accumulation assay in transfected HEK293 cells, immunofluorescence for receptor localization in osteoblastogenesis model Molecular and cellular endocrinology Low 25591908
2022 STC1 upregulates SMAD7 in a UCP2-dependent manner in alveolar epithelial and fibroblast cells, induces demethylation of the SMAD7 promoter and acetylation of SMAD7 protein, and attenuates pulmonary fibrosis in a bleomycin mouse model. STC1 also stimulates glycolysis, acetyl-CoA synthesis, and the methionine/cysteine-glutathione pathway as shown by comprehensive metabolomics. Metabolomics (capillary electrophoresis-TOF MS), Western blotting, promoter methylation assay, UCP2-dependent knockdown rescue, bleomycin mouse model American journal of respiratory cell and molecular biology Low 35696344
2020 In fibroblast-derived STC1 regulation of lung adenocarcinoma: STC1 secreted by tumor-associated fibroblasts (TAFs) suppresses tumor-associated macrophage (TAM) differentiation at least in part by sequestering GRP94 (an autocrine macrophage-differentiation-inducing factor) from binding to its cognate scavenger receptors; Stc1-deficient mouse lungs accumulate more mature TAMs, which secrete more TGF-β1 leading to increased TAF accumulation. Stc1 knockout mouse lung models (G12DKRAS, V600EBRAF), macrophage differentiation assays, GRP94-receptor binding competition (mechanistic inference from genetic model), TGF-β1 measurement Cell reports Medium 32579928
2023 CAF-derived STC1 directly binds Notch1 receptors (shown by Co-IP) to activate Notch signaling, promoting hepatocellular carcinoma stemness; STC1 is in turn a direct transcriptional target of CSL (a Notch transcriptional effector), forming a feedforward amplification loop. STC1 expression positively correlates with Notch1 expression in HCC tissue microarray. Co-immunoprecipitation (STC1–Notch1 binding), dual-luciferase reporter assay (CSL→STC1 promoter), sphere formation, sorafenib resistance assay, orthotopic xenograft Journal of translational medicine Low 37004088
2023 A20 inhibits GSK3β-mediated phosphorylation of STC1 at Thr86, slowing STC1 protein degradation; elevated STC1 then binds calreticulin (CRT) and retains it in mitochondria, preventing CRT translocation to the cell membrane (the 'eat-me' signal), thereby promoting immune evasion in colorectal cancer. Co-IP (STC1–CRT interaction), Western blotting for phospho-STC1(Thr86), cell surface CRT assay, gain/loss-of-function studies, in vivo mouse model Signal transduction and targeted therapy Medium 37607946
2024 STC1 competes with YAP for binding to βPIX within its KER domain in melanoma cells; competitive binding displaces YAP from βPIX, leading to YAP nuclear translocation and activation, which drives CCL2 upregulation. CCL2-recruited M2 macrophages secrete VEGFA, which activates AKT signaling in melanoma cells to further increase STC1 expression, forming a pro-metastatic feedback loop. STC1-induced YAP activation also increases PD-L1 expression. Mass spectrometry, Co-immunoprecipitation (STC1–βPIX, YAP–βPIX), Dual-luciferase reporter assay (CCL2 promoter), ChIP (YAP at CCL2 promoter), in vivo lung metastasis model Pharmacological research Medium 38768671
2012 STC1 overexpression in cervical cancer cells activates NF-κB p65, inhibiting cell proliferation and invasion; NF-κB p65 protein directly binds the STC1 promoter and activates STC1 expression (as confirmed by ChIP and reporter assay), establishing a regulatory loop. shRNA knockdown, STC1 overexpression, ChIP (NF-κB p65 at STC1 promoter), luciferase reporter assay, cell proliferation and invasion assays PloS one Low 23382863
2017 STC1 overexpression in hepatocellular carcinoma cells inhibits the p70S6K/phospho-rpS6 signaling pathway, reduces cellular ATP levels, activates AMPK, and shifts cellular energy metabolism toward lower glycolysis and oxygen consumption rates, thereby reducing tumor growth in a xenograft model. Lentiviral STC1 overexpression, Western blotting (p-rpS6, p70S6K, p-AMPK), ATP measurement, Seahorse metabolic flux analysis (glycolysis/OCR), xenograft model Oncotarget Low 29467934
2023 METTL3-mediated m6A methylation increases the mRNA stability of STC1 (and GDF6) in dental pulp stem cells, promoting dentinogenesis differentiation; METTL3 knockdown impairs differentiation while overexpression promotes it. MeRIP-seq, RNA stability assay (actinomycin D chase), lentiviral METTL3 knockdown/overexpression, ALP/alizarin red staining, direct pulp capping rat model BMC oral health Low 37041485
2012 PACAP induces STC1 gene expression in rat cortical neurons through cAMP and ERK1/2 signaling but not through canonical cAMP-dependent PKA; PACAP-mediated ERK1/2 activation occurs downstream of cAMP but independently of PKA, distinguishing this neuroprotective pathway from the canonical PKA-dependent cAMP pathway used for BDNF induction. PACAP receptor activation, pharmacological inhibitors (MEK/ERK inhibitor, PKA inhibitor H-89), cAMP and Ca2+ second messenger assays, STC1 mRNA quantification in cultured cortical neurons Journal of molecular neuroscience : MN Low 21975601

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochemical and biophysical research communications 640 15721318
2002 Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proceedings of the National Academy of Sciences of the United States of America 385 11854532
2010 Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell 180 20211136
2006 Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels. American journal of physiology. Cell physiology 171 16707556
2013 Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1). Stem cells (Dayton, Ohio) 160 23922312
2005 Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. The Journal of biological chemistry 157 15774482
2012 STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer research 152 23243022
2020 Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells. Cell research 109 32859993
2011 Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1. Molecular therapy : the journal of the American Society of Gene Therapy 105 22146344
2007 GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. American journal of physiology. Gastrointestinal and liver physiology 98 17290006
2000 A deep-coverage tomato BAC library and prospects toward development of an STC framework for genome sequencing. Genome research 92 10645957
2014 STC1 expression is associated with tumor growth and metastasis in breast cancer. Clinical & experimental metastasis 88 25391215
2016 Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. Journal of molecular endocrinology 86 26819328
2008 Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells. The FEBS journal 77 18691347
2000 Fatty acid-induced cholecystokinin secretion and changes in intracellular Ca2+ in two enteroendocrine cell lines, STC-1 and GLUTag. The Journal of physiology 76 11018115
1997 Peptones stimulate cholecystokinin secretion and gene transcription in the intestinal cell line STC-1. Endocrinology 75 9048620
2006 The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates. Molecular and cellular endocrinology 68 17092635
2004 Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Molecular endocrinology (Baltimore, Md.) 68 15131261
2011 TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. American journal of physiology. Cell physiology 60 21998136
1994 Characterization of the release of cholecystokinin from a murine neuroendocrine tumor cell line, STC-1. Biochimica et biophysica acta 59 8167157
2011 Green tea polyphenol epigallocatechin gallate activates TRPA1 in an intestinal enteroendocrine cell line, STC-1. Chemical senses 56 21890837
2012 Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells. Molecular nutrition & food research 50 22648622
2018 CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics 49 29721098
1999 Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics 49 10511551
1998 Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells. Endocrinology 48 9492022
2015 Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel. Toxicological sciences : an official journal of the Society of Toxicology 47 25787141
2020 Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1. Journal of animal science and biotechnology 46 33072314
2018 Berberine activates bitter taste responses of enteroendocrine STC-1 cells. Molecular and cellular biochemistry 45 29363059
2006 Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones. Biology of reproduction 45 16452456
2019 STC-1 ameliorates renal injury in diabetic nephropathy by inhibiting the expression of BNIP3 through the AMPK/SIRT3 pathway. Laboratory investigation; a journal of technical methods and pathology 44 30683904
1998 Expression of functional GABAA receptors in cholecystokinin-secreting gut neuroendocrine murine STC-1 cells. The Journal of physiology 42 9660895
2013 Stanniocalcin1 (STC1) Inhibits Cell Proliferation and Invasion of Cervical Cancer Cells. PloS one 41 23382863
2023 A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block "eat-me" signal. Signal transduction and targeted therapy 39 37607946
2017 Cysteine Linkages Accelerate Electron Flow through Tetra-Heme Protein STC. Journal of the American Chemical Society 38 29119787
2018 Stimulation of CCK and GLP-1 secretion and expression in STC-1 cells by human jejunal contents and in vitro gastrointestinal digests from casein and whey proteins. Food & function 37 30091426
2016 Elevated STC‑1 augments the invasiveness of triple‑negative breast cancer cells through activation of the JNK/c‑Jun signaling pathway. Oncology reports 37 27459971
2023 Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis. JCI insight 36 36795484
2015 Nesfatin-1 stimulates glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide secretion from STC-1 cells in vitro. Biochemical and biophysical research communications 34 25930999
2005 Characterization of bitter taste responses of intestinal STC-1 cells. Chemical senses 34 15741596
2002 Stanniocalcin 1 (STC1) protein and mRNA are developmentally regulated during embryonic mouse osteogenesis: the potential of stc1 as an autocrine/paracrine factor for osteoblast development and bone formation. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 34 11897801
2017 STC1 promotes cell apoptosis via NF-κB phospho-P65 Ser536 in cervical cancer cells. Oncotarget 32 28545028
1998 Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. Genomics 31 9480753
2010 Acute and chronic effects of dietary fatty acids on cholecystokinin expression, storage and secretion in enteroendocrine STC-1 cells. Molecular nutrition & food research 29 20352619
2020 Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. Cell reports 28 32579928
2021 Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression. Cancer medicine 27 33543830
1997 Prohormone convertase 2 is necessary for the formation of cholecystokinin-22, but not cholecystokinin-8, in RIN5F and STC-1 cells. Endocrinology 27 9275044
2020 Trichostatin A Induces Autophagy in Cervical Cancer Cells by Regulating the PRMT5-STC1-TRPV6-JNK Pathway. Pharmacology 26 33142290
2019 STC1 regulates glioblastoma migration and invasion via the TGF‑β/SMAD4 signaling pathway. Molecular medicine reports 26 31432189
2010 Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2. American journal of physiology. Cell physiology 26 20219951
2021 MiR-144-3p targets STC1 to activate PI3K/AKT pathway to induce cell apoptosis and cell cycle arrest in selenium deficiency broilers. Journal of inorganic biochemistry 25 34800749
2003 The STC-1 cells express functional orexin-A receptors coupled to CCK release. Biochemical and biophysical research communications 25 12943684
2019 Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1). Cancer cell international 24 31889892
2021 Epithelial expression and role of secreted STC1 on asthma airway hyperresponsiveness through calcium channel modulation. Allergy 23 33378582
2009 Peptide-YY is released by the intestinal cell line STC-1. Journal of food science 22 19323755
1993 Potassium channels regulate cholecystokinin secretion in STC-1 cells. Biochemical and biophysical research communications 22 8216272
2024 STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop. Pharmacological research 21 38768671
2021 Abnormal proinflammatory and stressor environmental with increased the regulatory cellular IGF-1/PAPP-A/STC and Wnt-1/β-Catenin canonical pathway in placenta of women with Chronic venous Disease during Pregnancy. International journal of medical sciences 21 34220309
1996 Pituitary adenylate cyclase-activating polypeptide stimulates cholecystokinin secretion in STC-1 cells. The American journal of physiology 21 8843778
2019 A Possible Mechanism: Genistein Improves Metabolism and Induces White Fat Browning Through Modulating Hypothalamic Expression of Ucn3, Depp, and Stc1. Frontiers in endocrinology 20 31379744
2016 STC1 and NF-κB p65 (Rel A) is Constitutively Activated in Colorectal Cancer. Clinical laboratory 20 27156337
2023 The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma. Journal of translational medicine 19 37004088
2021 Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction. Circulation journal : official journal of the Japanese Circulation Society 19 33716265
2021 Bacillus Subtilis Promotes the Release of 5-HT to Regulate Intestinal Peristalsis in STC Mice via Bile Acid and Its Receptor TGR5 Pathway. Digestive diseases and sciences 19 34797444
2020 MEG3 Induces Cervical Carcinoma Cells' Apoptosis Through Endoplasmic Reticulum Stress by miR-7-5p/STC1 Axis. Cancer biotherapy & radiopharmaceuticals 19 32379497
2013 Unsaturated aldehydes induce CCK secretion via TRPA1 in STC-1 cells. Molecular nutrition & food research 19 24357536
2022 Digestion characteristics of quinoa, barley and mungbean proteins and the effects of their simulated gastrointestinal digests on CCK secretion in enteroendocrine STC-1 cells. Food & function 18 35587126
2020 Dipeptidyl peptidase-4 and GLP-1 interplay in STC-1 and GLUTag cell lines. Peptides 18 32998057
2018 Novel Mechanism of Fatty Acid Sensing in Enteroendocrine Cells: Specific Structures in Oxo-Fatty Acids Produced by Gut Bacteria Are Responsible for CCK Secretion in STC-1 Cells via GPR40. Molecular nutrition & food research 18 29938900
2016 Flavonoids stimulate cholecystokinin peptide secretion from the enteroendocrine STC-1 cells. Fitoterapia 18 27496247
1999 Diazepam-binding inhibitor33-50 elicits Ca2+ oscillation and CCK secretion in STC-1 cells via L-type Ca2+ channels. The American journal of physiology 18 10070046
1998 Bombesin stimulates cholecystokinin secretion through mitogen-activated protein-kinase-dependent and -independent mechanisms in the enteroendocrine STC-1 cell line. The Biochemical journal 18 9512470
2022 Circular RNA circPOSTN promotes neovascularization by regulating miR-219a-2-3p/STC1 axis and stimulating the secretion of VEGFA in glioblastoma. Cell death discovery 17 35927233
2016 Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. PloS one 17 27846263
2013 Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proceedings of the National Academy of Sciences of the United States of America 16 23613586
2000 Control of CCK gene transcription by PACAP in STC-1 cells. American journal of physiology. Gastrointestinal and liver physiology 16 10960361
2022 NF-κB-upregulated miR-155-5p promotes hepatocyte mitochondrial dysfunction to accelerate the development of nonalcoholic fatty liver disease through downregulation of STC1. Journal of biochemical and molecular toxicology 15 35603999
2020 Long Noncoding RNA MALAT1 Promotes the Development of Colon Cancer by Regulating miR-101-3p/STC1 Axis. OncoTargets and therapy 15 32431516
2017 Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells. Current microbiology 15 28905106
1993 Calcium-dependent regulation of cholecystokinin secretion and potassium currents in STC-1 cells. The American journal of physiology 15 8333529
2021 Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis. Technology in cancer research & treatment 14 33784880
2016 STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells. Oncology reports 14 27461417
2012 STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons. Journal of molecular neuroscience : MN 14 21975601
2010 Production of calcium maintenance factor Stanniocalcin-1 (STC1) by the equine endometrium during the early pregnant period. The Journal of reproduction and development 14 21139325
2007 Intestinal STC-1 cells respond to five basic taste stimuli. Neuroreport 14 18007200
2022 Synergistic Effect of Kokumi-Active γ-Glutamyl Peptides and l-Glutamate on Enhancing Umami Sensation and Stimulating Cholecystokinin Secretion via T1R1/T1R3 Activation in STC-1 Cells. Journal of agricultural and food chemistry 13 36318610
2018 MSCs protect endothelial cells from inflammatory injury partially by secreting STC1. International immunopharmacology 13 29857240
2017 Effects of STC1 overexpression on tumorigenicity and metabolism of hepatocellular carcinoma. Oncotarget 13 29467934
2016 Effects of abalone (Haliotis discus hannai Ino) gonad polysaccharides on cholecystokinin release in STC-1 cells and its signaling mechanism. Carbohydrate polymers 13 27474567
1995 Galanin inhibits cholecystokinin secretion in STC-1 cells. Biochemical and biophysical research communications 13 7488089
2024 In Vitro Hypoglycemic Activities of Lactobacilli and Bifidobacterium Strains from Healthy Children's Sources and Their Effect on Stimulating GLP-1 Secretion in STC-1 Cells. Foods (Basel, Switzerland) 12 38397496
2020 Multifactor dimensionality reduction reveals a strong gene-gene interaction between STC1 and COL11A1 genes as a possible risk factor of knee osteoarthritis. Molecular biology reports 12 32140959
1999 Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II. Biochemical and biophysical research communications 12 9920804
1996 Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells. The American journal of physiology 12 8779971
2024 Effects and mechanisms of sciadonic acid on colonic transit function through regulating 5-HT4/cAMP/PKA/AQP4 signaling pathway in STC model mice. The Journal of nutritional biochemistry 11 38851516
2022 Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis. American journal of respiratory cell and molecular biology 11 35696344
2021 Circ-140/chi-miR-8516/STC1-MMP1 Regulates αs1-/β-Casein Secretion and Lipid Formation in Goat Mammary Epithelial Cells. Genes 11 33946970
2016 Pregnane Glycosides from Cynanchum marnierianum Stimulate GLP-1 Secretion in STC-1 Cells. Planta medica 11 27224272
2015 STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition. Molecular and cellular endocrinology 11 25591908
2012 Hormone profiling in a novel enteroendocrine cell line pGIP/neo: STC-1. Metabolism: clinical and experimental 11 22768997
2023 METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability. BMC oral health 10 37041485

Missed literature

Know a paper Affinage missed for STC1? Flag it for the maintainers and the community.

No submissions yet.