Affinage

NOTCH1

Neurogenic locus notch homolog protein 1 · UniProt P46531

Length
2555 aa
Mass
272.5 kDa
Annotated
2026-06-10
100 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NOTCH1 is a ligand-activated transmembrane receptor whose released intracellular domain (NICD/N1ICD) drives a transcriptional program governing cell-fate decisions across vascular, cardiac, immune, renal, and epithelial tissues (PMID:29158473, PMID:26062937, PMID:36583388). Signaling initiates when DSL ligands such as DLL4 engage the receptor and trigger clathrin/dynamin-dependent endocytosis of NOTCH1 into SARA-positive endosomes, a step coupled to ligand transendocytosis and required for productive signal transduction (PMID:26522918); receptor competence is tuned by O-fucosylation of specific EGF repeats, which controls Lunatic Fringe-mediated potentiation of DLL1-NOTCH1 activation and receptor trafficking (PMID:32820046), and by GSK3β-controlled postendocytic recycling that sets surface receptor levels (PMID:29237816). Signal output is determined by the number of NICD molecules reaching the nucleus and the duration of the NICD-RBPJk-MAML-DNA complex, with tissue-specific γ-secretase cleavage choices tuning NICD stability (PMID:26062937). NICD abundance and activity are extensively post-translationally controlled: p300-dependent acetylation extends N1ICD half-life while SIRT1 deacetylates and destabilizes it (PMID:29186476, PMID:38017499); FBW7/FBXW7 mediates phosphorylation-dependent nuclear degradation (PMID:25955618); c-Cbl monoubiquitinates NOTCH1 for lysosomal degradation upon PI3K/AKT withdrawal (PMID:26052821); the microprotein N1DARP displaces the deubiquitinase USP10 to promote K11/K48 polyubiquitination and proteasomal turnover (PMID:37714834); RFC4 stabilizes NICD1 by blocking CDK8/FBXW7-dependent degradation in a feed-forward loop (PMID:33976158); and c-Src phosphorylates NICD to reduce MAML recruitment and transcriptional output (PMID:30341382). Nuclear NICD transactivates targets including HES1, MYC, SERPINE1, and IL-6 and represses VE-cadherin via SNAI1 and ERG (PMID:33435713, PMID:28314854, PMID:26847059, PMID:33109684). In endothelium, NOTCH1 functions as a shear-stress mechanosensor that maintains junctional integrity and suppresses proliferation and inflammation, with loss promoting atherosclerosis and metastatic endothelial activation (PMID:26552708, PMID:29158473, PMID:28238683). Context-dependent roles span ventricular cardiomyocyte specification and proliferation (PMID:36583388, PMID:29186476), aortic and cardiac morphogenesis (PMID:29093270, PMID:34571841), podocyte injury in diabetic and Fabry kidney disease (PMID:26293507, PMID:26206887), and oncogenic signaling integrated with PI3K/Akt, NF-κB, HIF-1α, and TGF-β/Smad3 pathways (PMID:18924608, PMID:18292500).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2004 Medium

    Established an upstream brake on NOTCH1 activation during T-cell development by linking p53 to the proteolytic machinery that releases NICD.

    Evidence Trp53-/- mouse thymocytes with NIC detection and CD4/CD8 flow cytometry, mapping p53 repression of Presenilin1

    PMID:14991602

    Open questions at the time
    • Does not establish direct p53 binding to the PS1 promoter
    • Effect on other tissues not tested
  2. 2008 Medium

    Defined how NOTCH1 abundance is driven by oncogenic and hypoxic inputs, showing PI3K/Akt-NF-κB and HIF-1α converge to upregulate Notch1 and make it required for transformation.

    Evidence Melanoma cell lines and xenografts with pathway-specific inhibitors and Notch1 knockdown; plus Co-IP linking N1ICD to phospho-Smad3 in dendritic cells

    PMID:18292500 PMID:18924608

    Open questions at the time
    • Direct transcription-factor occupancy on the NOTCH1 locus not shown in melanoma context
    • Smad3 interaction surface on NICD not mapped
  3. 2011 Medium

    Identified a receptor tyrosine kinase, DDR1, as a physical NOTCH1 partner that links collagen sensing to canonical Notch target activation.

    Evidence Tandem affinity purification, Co-IP, nuclear fractionation and DDR1 knockdown with γ-secretase inhibitor

    PMID:21398698

    Open questions at the time
    • Mechanism by which DDR1 activates Notch cleavage unresolved
    • Single-lab interaction without structural detail
  4. 2015 High

    Resolved that NOTCH1/NOTCH2 functional divergence is encoded by signal strength and NICD complex duration rather than intrinsic ICD differences, with γ-secretase cleavage choice tuning stability.

    Evidence Intracellular domain swap mouse model with genetic epistasis across multiple tissues

    PMID:26062937

    Open questions at the time
    • Molecular basis of tissue-specific scissile bond choice not defined
    • Does not map cofactors setting complex half-life
  5. 2015 Medium

    Built the degradation arm of NICD regulation, defining FBW7-mediated nuclear degradation and PI3K/AKT-gated c-Cbl monoubiquitination/lysosomal turnover.

    Evidence siRNA/overexpression with migration assays in HCC; ubiquitin capture and Co-IP in cells with PI3K inhibition and dominant-negative AKT

    PMID:25955618 PMID:26052821

    Open questions at the time
    • Phosphodegron residues recognized by FBW7 not directly mapped here
    • c-Cbl ubiquitination site not defined
  6. 2015 Medium

    Established the transcriptional control of the NOTCH1 gene itself in keratinocytes, identifying DLX5/EGR3 and ERβ as regulators of PolII recruitment and pause release.

    Evidence Bioinformatic screen, ChIP for PolII occupancy, ERβ gain-of-function in vitro and in xenotransplants

    PMID:24743148

    Open questions at the time
    • Generality beyond squamous keratinocytes untested
    • Direct DLX5/EGR3 binding sites not mapped
  7. 2015 High

    Defined NOTCH1 as a protective, anti-inflammatory regulator of endothelium suppressed by inflammatory lipids/cytokines via STAT3, with loss promoting atherosclerosis.

    Evidence siRNA in human aortic ECs, monocyte adhesion assays, Notch1 heterozygous atherosclerosis mouse model

    PMID:26552708

    Open questions at the time
    • Direct STAT3 action on the NOTCH1 locus not shown
    • Downstream effectors of EC inflammation incompletely defined
  8. 2017 High

    Demonstrated that ligand-induced NOTCH1 endocytosis into SARA endosomes is required for signaling, and that GSK3β-controlled recycling tunes surface receptor levels.

    Evidence Live-cell imaging with clathrin/dynamin inhibition and ligand co-culture; GSK3β inhibition with recycling and NICD production assays

    PMID:26522918 PMID:29237816

    Open questions at the time
    • Adaptors coupling NOTCH1 to clathrin not identified
    • GSK3β substrate residue on Notch1 unmapped
  9. 2017 High

    Established NOTCH1 as a vascular mechanosensor, scaling signaling to shear stress to maintain junctional integrity and suppress proliferation through calcium signaling.

    Evidence Shear stress assays, siRNA knockdown, calcium rescue, adult endothelial Notch1-knockout atherosclerosis mouse model

    PMID:29158473

    Open questions at the time
    • The force-transducing element of NOTCH1 not structurally defined
    • Link between flow sensing and proteolytic activation unresolved
  10. 2017 Medium

    Expanded NOTCH1 partner biology to cytoskeletal and adhesion contexts, identifying keratin 8/18 as stabilizers in colonocytes and MEGF10 as a disease-relevant ICD partner.

    Evidence PLA and reciprocal Co-IP with knockout/rescue (K8/K18); reciprocal Co-IP with pathogenic MEGF10 mutation disruption

    PMID:28475172 PMID:28498977

    Open questions at the time
    • How keratins stabilize Notch1 protein not mechanistically resolved
    • MEGF10-Notch1 interaction interface not mapped
  11. 2017 High

    Showed activated endothelial NOTCH1 (N1ICD) is pro-metastatic, inducing senescence, chemokines and VCAM1 to drive tumor-cell adhesion and intravasation.

    Evidence Conditional N1ICD EC expression, Notch1-blocking antibody, VCAM1 blockade, ovarian carcinoma and lung colonization mouse models

    PMID:28238683

    Open questions at the time
    • Transcriptional targets driving SASP not fully enumerated
    • Context distinguishing protective vs pro-metastatic EC Notch1 unclear
  12. 2017 Medium

    Defined tissue-specific transcriptional outputs of NOTCH1 in tumor and fibroblast contexts, including MYC transactivation in CLL and IL-6-dependent angiogenic suppression in fibroblasts.

    Evidence ICN1 detection and ChIP/reporter on B-cell MYC elements in primary CLL; FSP-1-Cre;ROSA-NICD1 wound-healing mice with IL-6 validation; CRISPR Notch1 ablation radiosensitizing GBM

    PMID:28314854 PMID:29152141 PMID:33109684

    Open questions at the time
    • Opposing growth effects across cell types mechanistically unreconciled
    • Direct vs indirect target status of IL-6 not fully resolved
  13. 2018 High

    Established acetylation as a positive NICD stability switch and phosphorylation by c-Src as a negative one, coupling kinase signaling to transcriptional output.

    Evidence Acetylation assays and SIRT1 gain/loss with in vivo cardiac regeneration; Co-IP, in vitro kinase assay and mutagenesis with reporter (Src)

    PMID:29186476 PMID:30341382

    Open questions at the time
    • Acetylated lysines on N1ICD not enumerated
    • Crosstalk between Src phosphorylation and FBW7/Cbl pathways untested
  14. 2019 Medium

    Extended NOTCH1 regulation to cell-cycle and B-cell signaling kinases, identifying PLK1 control at G2/M and DNA damage and a BTK-NICD axis transmitting BCR signals in CLL.

    Evidence Kinase screen plus Co-IP and cell-cycle analysis (PLK1); PLA and qRT-PCR of targets in CLL patient samples with ibrutinib (BTK)

    PMID:31578228 PMID:31597699

    Open questions at the time
    • Whether PLK1 directly phosphorylates Notch1 not established
    • BTK-NICD interaction interface and direct phosphorylation not defined
  15. 2020 High

    Defined the glycosylation logic of NOTCH1 ligand selectivity and trafficking, mapping specific O-fucose sites required for Fringe-mediated DLL1 potentiation; and identified a PAK1-Notch1 axis controlling crypt homeostasis.

    Evidence Cell-based signaling/binding assays with mass spectrometry and EGF O-fucose site mutants; Co-IP and co-localization in organoids with PAK1/Notch1 perturbation and double-KO mice

    PMID:32820046 PMID:33189893

    Open questions at the time
    • Structural basis of Fringe-modified ligand discrimination not solved
    • How PAK1 binding restrains Notch1 activation unresolved
  16. 2021 High

    Defined transcriptional and physiological consequences of endothelial NOTCH1, repressing VE-cadherin via SNAI1/ERG and cooperating with pericyte NOTCH3 to stabilize vasculature.

    Evidence VE-cadherin promoter dissection with TF knockdown and transgenic NICD1 mice (albuminuria); vascular co-culture with NOTCH1/NOTCH3 siRNA and DLL4 ligand identification; Dll4-neutralization PH model

    PMID:33435713 PMID:34739767 PMID:34878922

    Open questions at the time
    • Threshold distinguishing protective vs barrier-disrupting Notch1 unclear
    • Reconciliation of junction stabilization with VE-cadherin repression incomplete
  17. 2021 High

    Established a stabilizing feed-forward loop (RFC4 protecting NICD1 from CDK8/FBXW7 degradation) and cell-type-specific pathological roles in podocytes, fibrosis, and bone.

    Evidence Reciprocal Co-IP and degradation assays with target validation in NSCLC; podocyte-specific Notch1 conditional KO diabetic mice; αSMACreERT2 NICD1 fracture model with anti-NRR1 antibody

    PMID:26293507 PMID:32141629 PMID:33976158

    Open questions at the time
    • Generality of RFC4 loop beyond NSCLC untested
    • Compensatory Notch2 upregulation complicates Notch1-specific interpretation
  18. 2022 High

    Used engineered and genetic systems to causally dissect NOTCH1's role in cardiomyocyte fate and proliferation and in ligand-independent oncogenic activation.

    Evidence CRISPR NOTCH1 KO in human iPSC-cardiomyocytes with scRNA-seq and electrophysiology; optogenetic optoNotch ligand-independent N1ICD control in breast cancer cells

    PMID:35585598 PMID:36583388

    Open questions at the time
    • Effector genes driving ventricular vs atrial fate choice incompletely mapped
    • optoNotch in vivo relevance untested
  19. 2023 Medium

    Defined ubiquitin-pathway control of NICD by the USP10 deubiquitinase (disruptable by the microprotein N1DARP) and SIRT1-driven deacetylation/degradation, and a fate-controlling role in alveolar epithelium.

    Evidence Co-IP, ubiquitination assays and stapled-peptide functional studies in pancreatic cancer (N1DARP/USP10); PLA and in vivo heart-failure model (SIRT1); in vivo and ex vivo IPF lung slices with Notch inhibition

    PMID:36047984 PMID:37714834 PMID:38017499

    Open questions at the time
    • Endogenous role of N1DARP microprotein beyond cancer unclear
    • JAK/STAT linkage in AEC2s remains putative

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse post-translational regulators (acetylation, multiple ubiquitin ligases/DUBs, tyrosine kinases) are integrated to set NICD dose and duration in a given cell type, and what determines NOTCH1's context-dependent oncogenic versus tumor-suppressive output, remain unresolved.
  • No unified quantitative model of competing NICD stabilizers and degraders
  • Determinants of tissue-specific protective vs pathogenic Notch1 outcomes undefined
  • Structural basis of mechanosensing and ligand-dependent cleavage not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0060089 molecular transducer activity 3 GO:0140299 molecular sensor activity 1
Localization
GO:0005634 nucleus 3 GO:0005886 plasma membrane 3 GO:0005768 endosome 2
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-1643685 Disease 4 R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3
Partners
BTKDDR1FBXW7MAMLRBPJRFC4SIRT1USP10
Complex memberships
NICD-RBPJk-MAML transcriptional activation complex

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 Ligand-induced endocytosis of Notch1 into SARA-positive endosomes is required for signal transduction; inhibition of clathrin- and dynamin-dependent endocytosis in the receptor-expressing cell impairs ligand-induced Notch1 signaling, and Notch1 endocytosis is accompanied by transendocytosis of ligand into the signal-receiving cell. Live-cell imaging, clathrin/dynamin inhibition, ligand-expressing co-culture Biochimica et biophysica acta High 26522918
2018 c-Src kinase physically interacts with the Notch1 intracellular domain (NICD), directly phosphorylates it at specific tyrosine residues downstream of β3 integrin/MAGP2 signaling, and this phosphorylation attenuates Notch1-mediated transcription by decreasing MAML recruitment to the co-transcriptional complex and reducing NICD half-life. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis, transcriptional reporter assay Scientific reports High 30341382
2018 The Notch1 intracellular domain (N1ICD) is reversibly acetylated in proliferating neonatal cardiomyocytes; acetylation extends N1ICD half-life and enhances its transcriptional activity to sustain cardiomyocyte proliferation and counteract apoptosis, while SIRT1 acts as a deacetylase that reverses N1ICD acetylation and dampens its stability. Acetylation assays, SIRT1 overexpression, constitutively acetylated N1ICD-p300 fusion protein, adeno-associated viral vector delivery, neonatal mouse apical resection model Cardiovascular research High 29186476
2023 SIRT1 deacetylates and promotes degradation of the active Notch1 intracellular domain (NICD); mechanistically, dapagliflozin reduces SIRT1 phosphorylation (preventing its ubiquitination/degradation), enabling nuclear SIRT1 translocation and binding to NICD, leading to NICD deacetylation, degradation, and inactivation of Notch1 signaling, thereby attenuating endothelial-mesenchymal transition. Western blotting, confocal proximity ligation assay, in vivo heart failure model, in vitro HUVEC/MAEC assays, SIRT1 inhibition experiments Cardiovascular diabetology Medium 38017499
2023 The microprotein N1DARP competitively disrupts the interaction between N1ICD and the deubiquitinase USP10, thereby promoting K11- and K48-linked polyubiquitination of N1ICD and its proteasome-mediated degradation, suppressing canonical and non-canonical Notch1 signaling in pancreatic cancer. Co-immunoprecipitation, ubiquitination assays, N1DARP knockout in organoids and KPC mice, cell-penetrating stapled peptide functional studies Cell discovery High 37714834
2021 RFC4 directly binds to the Notch1 intracellular domain (NICD1) and competitively abrogates CDK8/FBXW7-mediated degradation of NICD1, thereby stabilizing it; RFC4 is itself a transcriptional target of Notch1 signaling, forming a positive feedback loop that sustains NICD1 overactivation in NSCLC. Co-immunoprecipitation, pulldown, ubiquitination/degradation assays, transcriptional target validation, NSCLC cell lines and patient datasets Nature communications High 33976158
2015 PI3K/AKT signaling inhibits lysosomal degradation of NOTCH1; withdrawal of PI3K/AKT activity leads to NOTCH1 tyrosine phosphorylation, monoubiquitination by the E3 ligase c-Cbl (shown by co-immunoprecipitation), and subsequent lysosomal degradation of NOTCH1 protein. PI3K inhibitor treatment, dominant-negative AKT transfection, ubiquitin capture assay, co-immunoprecipitation, colocalization analysis Genes, chromosomes & cancer Medium 26052821
2015 FBW7 (FBXW7) E3 ubiquitin ligase mediates phosphorylation-dependent degradation of the Notch1 intracellular domain in the nucleus; loss of FBXW7 in hepatocellular carcinoma increases NICD levels and promotes cell migration and invasion via Notch1 downstream molecules. siRNA knockdown, Fbxw7 overexpression, migration/invasion assays, Western blot, tissue microarray International journal of oncology Medium 25955618
2019 PLK1 interacts with NOTCH1 and regulates NOTCH1 expression at the G2/M transition; during DNA damage, PLK1 activity is inhibited, NOTCH1 expression is maintained, and arsenite-induced genotoxic stress causes a PLK1-dependent signaling response that antagonizes NOTCH1's role in the DNA damage checkpoint. Chemical library kinase screen, co-immunoprecipitation, cell cycle analysis, PLK1 inhibition, DNA damage assays The Journal of biological chemistry Medium 31597699
2017 GSK3β regulates Notch1 signaling by controlling postendocytic receptor recycling; GSK3β inhibition increases Notch1 cell surface levels, elevates NICD production and signaling activity, and alters Notch1 localization within a tubulovesicular compartment. GSK3β inhibition, immunolocalization, Notch1 transport/recycling assays, NICD production measurement Molecular biology of the cell Medium 29237816
2011 DDR1 receptor tyrosine kinase physically interacts with Notch1 (identified by tandem affinity protein purification); upon ligand-mediated DDR1 activation, Notch1 is activated and bound to DDR1, activating canonical Notch1 targets (Hes1, Hey2), and DDR1 knockdown abolishes collagen I-induced nuclear accumulation of active Notch1. Tandem affinity protein purification, co-immunoprecipitation, nuclear fractionation, DDR1 knockdown, gamma-secretase inhibitor treatment The Journal of biological chemistry Medium 21398698
2008 Notch1 intracellular domain physically interacts with phospho-Smad3 (pSmad3) in dendritic cells; overexpression of N1ICD facilitates pSmad3 nuclear translocation and enhances pSmad3 transcriptional activity on Smad-sensitive promoters, mechanistically linking Notch1 signaling to TGF-β-mediated Treg effector function. Co-immunoprecipitation, luciferase reporter assay, antibody blockade of Notch1/Jagged1, in vitro Treg suppression assay Journal of immunology Medium 18292500
2017 Keratin 8 (K8) and its partner K18 physically interact with Notch1 receptor (shown by proximity ligation assay and co-immunoprecipitation in colonocytes); K8/K18 enhance Notch1 protein levels and activity in a dose-dependent manner, and K8 loss reduces full-length Notch1, NICD, and downstream target gene expression, shifting colonic differentiation toward goblet cell and enteroendocrine fates. Proximity ligation assay, co-immunoprecipitation, K8-knockout mice, CRISPR/Cas9 Caco-2 knockout, K8/K18 re-expression rescue Cell death and differentiation High 28475172
2020 Fringe enzymes and canonical Notch ligands differentially regulate NOTCH1 vs. NOTCH2; DLL4 activates NOTCH1 more than twice as potently as NOTCH2 in the absence of Fringes; O-fucosylation on EGF8 and EGF12 of NOTCH1 is required for Lunatic Fringe-mediated enhancement of DLL1-NOTCH1 activation, and O-fucosylation on EGF9 is important for receptor trafficking of both NOTCH1 and NOTCH2. Cell-based Notch signaling and ligand-binding assays, mass spectrometry for O-fucose, Fringe enzyme mutagenesis, EGF domain O-fucose site mutants The Journal of biological chemistry High 32820046
2015 Endothelial NOTCH1 is suppressed by inflammatory lipids (Ox-PAPC) and cytokines (TNF, IL-1β) through a STAT3-dependent mechanism; siRNA-mediated reduction of NOTCH1 in human aortic endothelial cells increases inflammatory molecules and monocyte binding in the absence of inflammatory stimulus, and endothelial Notch1 heterozygous mice show higher diet-induced atherosclerosis. siRNA knockdown, inflammatory lipid treatment, monocyte adhesion assay, Notch1 heterozygous mouse atherosclerosis model The Journal of experimental medicine High 26552708
2017 Endothelial NOTCH1 functions as a mechanosensor: NOTCH1 localizes downstream of flow and canonical NOTCH signaling scales with the magnitude of fluid shear stress; NOTCH1 is required for maintenance of junctional integrity and suppression of proliferation under laminar shear stress, and loss of NOTCH1 destabilizes junctions and triggers proliferation through changes in intracellular calcium signaling. Shear stress assays, siRNA knockdown, live imaging, gene expression profiling, calcium signaling rescue experiments, adult endothelial Notch1-knockout mouse atherosclerosis model Nature communications High 29158473
2021 Endothelial NOTCH1 activation suppresses VE-cadherin expression through the transcription factors SNAI1 (binding -373 E-box) and ERG (binding -134/-118 ETS element) on the VE-cadherin promoter; constitutive endothelial NICD1 expression in mice induces severe albuminuria associated with decreased VE-cadherin and reduced glomerular endothelial glycocalyx. NICD1 lentiviral infection, DLL4 treatment, VE-cadherin promoter analysis, transgenic mouse model (ZEG-NICD1/Tie2-tTA/Tet-O-Cre), SNAI1/ERG knockdown, monolayer permeability assay Circulation research High 33435713
2017 MEGF10 interacts with Notch1 via their respective intracellular domains (shown by reciprocal co-immunoprecipitation); the pathogenic MEGF10 p.C774R mutation impairs this interaction, and MEGF10 regulation of myoblast proliferation and migration is mediated at least in part through Notch1 signaling. Reciprocal co-immunoprecipitation, shRNA knockdown, pathogenic mutation overexpression, Megf10-/- mouse myoblast proliferation/migration assays Human molecular genetics Medium 28498977
2015 In the intracellular domain swap mouse model, differences between Notch1 and Notch2 outcomes reflect signal strength (number of NICD molecules reaching the nucleus, integrating ligand-mediated release and nuclear translocation) and duration (half-life of NICD-RBPJk-MAML-DNA complexes); tissue-specific NICD stability differences are caused by alternative scissile bond choices by tissue-specific γ-secretase complexes. Intracellular domain swap mouse model, genetic epistasis across multiple tissues (T-cell development, skin, inner ear, lung, retina), gamma-secretase complex analysis Development (Cambridge, England) High 26062937
2004 p53 negatively regulates Notch1 activation during T-cell development through Presenilin1 (PS1): p53 represses PS1 expression, and PS1 cleaves Notch1 to release the NIC; Trp53-/- thymocytes show elevated NIC levels and altered CD4+/CD8+ T-cell ratios consistent with increased Notch1 activation, phenocopying NIC-overexpressing mice. Thymoma cell lines, Trp53-/- mouse thymocytes, NIC protein detection, flow cytometry for CD4/CD8 populations European journal of immunology Medium 14991602
2021 Pericyte NOTCH3 and endothelial NOTCH1 cooperate for pericyte-induced vascular stabilization: DLL4 expression in pericytes is dependent on NOTCH3, and DLL4 is the key ligand activating endothelial NOTCH1; loss of either NOTCH3 or NOTCH1 decreases VE-cadherin accumulation at adherens junctions and increases junction motility in vitro. In vitro vascular co-culture models, siRNA knockdown of NOTCH1 and NOTCH3, VE-cadherin imaging, DLL4 ligand identification American journal of physiology. Cell physiology Medium 34878922
2021 Notch1 activation in podocytes drives diabetic kidney disease: conditional deletion of Notch1 (but not Notch2) in podocytes markedly ameliorates albuminuria and mesangial expansion in diabetic mice; Notch1-null podocytes are protected from apoptosis and dedifferentiation in vitro; deletion of Notch1 leads to compensatory upregulation of Notch2. NPHS2(cre)Notch1(flox/flox) conditional knockout mice, diabetic nephropathy model, in vitro podocyte apoptosis/dedifferentiation assays, Notch2 transgenic overexpression Diabetes High 26293507
2019 NOTCH1-ICD physically interacts with BTK (demonstrated by in situ proximity ligation assay); BCR stimulation increases nuclear NOTCH1-ICD and activates HES1, DTX1, and c-MYC transcription; ibrutinib (BTK inhibitor) disrupts NOTCH1-ICD/BTK complexes and reduces NOTCH1 activation in CLL. Western blotting, confocal proximity ligation assay, qRT-PCR for downstream targets, ex vivo CLL patient samples Clinical cancer research Medium 31578228
2017 Activated Notch1 (N1ICD) in endothelial cells induces cellular senescence and expression of chemokines and VCAM1, promoting neutrophil infiltration, tumor cell adhesion to the endothelium, and intravasation; treatment with Notch1-blocking antibodies or genetic ablation of EC Notch signaling inhibited these pro-metastatic events. Conditional N1ICD expression in ECs, Notch1-blocking antibody treatment, VCAM1 blockade, peritoneal ovarian carcinoma mouse model, lung colonization assays Cancer cell High 28238683
2014 Notch1 heterozygosity in aortic valve interstitial cells produces a myofibroblast-like phenotype with higher cadherin-11 (regulated by Akt activity) and decreased Runx2; under cyclic strain, Notch1+/- AVICs show upregulated Akt phosphorylation and smooth muscle α-actin, leading to enhanced dystrophic (not osteogenic) calcific nodule formation. Murine immortalized Notch1+/- AVIC isolation, cyclic strain bioreactor, Akt inhibition, calcification nodule assays, molecular signaling pathway analysis Arteriosclerosis, thrombosis, and vascular biology Medium 26023079
2017 NOTCH1 transactivates MYC in CLL via binding to B-cell-specific regulatory elements; active intracellular NOTCH1 (ICN1) is detectable in ~50% of peripheral blood CLL cases lacking NOTCH1 mutations and correlates with a NOTCH1 gene-expression signature enriched for B-cell proliferation and survival regulators. ICN1 protein detection, ChIP/reporter assays for MYC regulatory elements, gene expression signature analysis in primary CLL samples Proceedings of the National Academy of Sciences of the United States of America Medium 28314854
2008 Hyperactivated PI3K/Akt signaling upregulates Notch1 through NF-κB activity, while hypoxia increases Notch1 mRNA and protein via HIF-1α stabilization; Notch1 is required for Akt and hypoxia to transform melanocytes and maintains cell proliferation and protects cells from stress-induced death in xenograft models. Human melanoma cell lines, xenograft model, PI3K/Akt inhibition, NF-κB inhibition, HIF-1α knockdown, Notch1 knockdown The Journal of clinical investigation Medium 18924608
2023 Notch1 signaling in type II alveolar epithelial cells (AEC2s) determines cell fate by inhibiting differentiation (reducing lamellar body compartment and surfactant proprotein processing capacity) and causing increased epithelial proliferation, putatively via altered JAK/STAT signaling; Notch1 activity is already activated early in IPF, and pharmacological inhibition of Notch in IPF-derived lung slices improved surfactant processing and reversed fibrosis. Notch1 NICD overexpression in vivo, bleomycin fibrosis model, human IPF precision-cut lung slices with Notch inhibition, flow cytometry, kinome profiling, primary murine/human AEC2s American journal of respiratory and critical care medicine Medium 36047984
2022 NOTCH1 deficiency in human iPSC-derived cardiomyocytes blocks ventricular-like cardiomyocyte differentiation and promotes atrial-like cardiomyocyte generation through shortening of action potential duration; NOTCH1 KO leads to biased differentiation of cardiac mesoderm toward epicardial and second heart field progenitors at the expense of first heart field progenitors, and defective cardiomyocyte proliferation with downregulated cell cycle progression pathways. CRISPR/Cas9 NOTCH1 deletion in human iPSCs, single-cell RNA-seq at multiple differentiation time points, action potential duration measurement Circulation research High 36583388
2022 Optogenetic NOTCH1 receptor (optoNotch) allows ligand-independent light-controlled activation of N1ICD and downstream transcription; NOTCH1 activation increases proliferation in MCF7 and MDA-MB-468 breast cancer cells and induces chemoresistance, with cell-type-specific migratory phenotypes. Optogenetic receptor engineering (optoNotch), 2D and 3D spheroid cultures, transcriptional activity assays, chemoresistance assays Cell communication and signaling Medium 35585598
2021 Reduced Notch1 cleavage in lung endothelial cells impairs endothelial barrier function and increases immune cell infiltration in vessel walls; Dll4-neutralizing antibodies inhibit Notch1 cleavage and induce pulmonary hypertension in mice, while overexpression of constitutively activated Notch1 attenuates pulmonary hypertension progression. Dll4-neutralizing antibody treatment in mice, Notch1 target gene array in human pulmonary microvascular ECs, constitutively activated Notch1 overexpression in vivo, PH mouse models, hemodynamic measurements Hypertension (Dallas, Tex. : 1979) Medium 34739767
2020 PAK1 directly co-localizes and physically interacts with Notch1 in colon epithelial cells; silencing of PAK1 leads to Notch1 activation, and Notch1 activation abrogates the PAK1-Notch1 interaction, identifying a PAK1-Notch1 axis that regulates intestinal crypt homeostasis through Notch1-dependent HES1 and Lgr5 expression. Co-immunoprecipitation, immunofluorescence co-localization in intestinal organoids and cell lines, PAK1/Notch1 siRNA, IL10/PAK1 double-knockout mice Cellular and molecular gastroenterology and hepatology Medium 33189893
2015 NOTCH1 gene transcription in keratinocytes is directly controlled by transcription factors DLX5 and EGR3 (required for RNA PolII recruitment to the NOTCH1 locus) and estrogen receptor β (ERβ, controlling NOTCH1 transcription through RNA PolII pause release); experimentally increased ERβ expression or ERβ agonist treatment promotes NOTCH1 expression and squamous differentiation in vitro and in mouse xenotransplants. Bioinformatics screening, ChIP (PolII occupancy), ERβ overexpression, ERβ agonist treatment, mouse xenotransplant model The Journal of clinical investigation Medium 24743148
2017 Notch1 inhibition in glioblastoma using CRISPR/Cas9-mediated ablation suppresses tumor growth, increases γH2AX foci (indicating impaired DNA repair), radiosensitizes GBM cells, impairs angiogenesis, and attenuates VEGF and hypoxic response to irradiation in xenografts. CRISPR/Cas9 Notch1 ablation, clonogenic assays, γH2AX immunofluorescence, xenograft tumor growth, immunofluorescence staining Oncotarget Medium 29152141
2021 Notch1 signaling in osteochondroprogenitor cells (overexpression of NICD1) during fracture healing increases periosteal cell proliferation and migration, expands αSMA-positive cells and their osteoblast progeny, reduces callus cartilage, increases mineralized callus, and improves bone biomechanical strength; conversely, anti-NRR1 antibody inhibition of Notch1 increases cartilage area and reduces callus bone mass. αSMACreERT2-Rosa-NICD1 transgenic mice, anti-NRR1 antibody treatment, fracture callus histology, biomechanical testing, in vitro proliferation/migration assays Journal of orthopaedic research Medium 32141629
2019 Notch1 activation in renal tubular epithelial cells and fibroblasts contributes to TGF-β1/Smad2/3-dependent myofibroblastic phenotype; TGF-β1 induces Notch1 activity and these phenotypic transitions are abolished by Notch1 knockdown or DAPT, and exacerbated by Notch1 overexpression or Jagged-1-Fc activation. Notch1 siRNA, DAPT inhibitor, Jagged-1-Fc activator, fibroblast and TEC in vitro cultures, ureteral obstructive model in rats, CKD patient biopsies Cell communication and signaling Medium 31718671
2015 Lyso-Gb3 activates Notch1 signaling in human podocytes, increasing active Notch1 and HES1; Notch1 signaling activates NF-κB to mediate inflammatory chemokine (MCP-1, RANTES) upregulation, and promotes fibrogenic responses including fibronectin upregulation; these effects are abolished by Notch1 siRNA or γ-secretase inhibition. Notch1 siRNA, γ-secretase inhibitor, NFκB inhibitor (parthenolide), lyso-Gb3 treatment of cultured human podocytes, Fabry kidney biopsy immunostaining Human molecular genetics Medium 26206887
2017 Notch1 activation in fibroblasts (FSP-1;ROSA Notch1 gain-of-function mice) suppresses fibroblast growth, migration, and differentiation into myofibroblasts, delays wound healing, diminishes collagen deposition, and impairs angiogenic response; IL-6 was identified as a functional Notch1 target in fibroblasts involved in regulating angiogenesis. FSP-1-Cre;ROSA-NICD1 transgenic mouse wound healing model, in vitro fibroblast migration/differentiation assays, IL-6 functional validation Life science alliance Medium 33109684
2018 Notch1 provides myocardial protection against ischemia-reperfusion injury by improving mitochondrial quality control: Notch1 overexpression increases ATP production, promotes mitochondrial fusion, decreases fission, and inhibits mitophagy by suppressing Pink1 expression and Mfn2/Parkin phosphorylation. Adenoviral Ad-N1ICD and Ad-shN1ICD in rat cardiomyocytes, ischemia-reperfusion injury model, mitophagy and mitochondrial dynamics assays, Pink1/Mfn2/Parkin pathway analysis Journal of cellular physiology Medium 30515819
2016 Notch1 (NICD) regulates the aggressiveness of differentiated thyroid cancer (DTC) by suppressing SERPINE1 (PAI-1): NICD induction reduces SERPINE1 expression in a dose-dependent manner and inhibits DTC cell growth and migration in vitro and in an orthotopic xenograft model. Doxycycline-inducible NICD expression system, microarray target discovery, SERPINE1 knockdown, orthotopic thyroid cancer xenograft Clinical cancer research Medium 26847059
2015 Notch1 heterozygous loss is sufficient to cause ascending aortic aneurysm in 129S6 background mice; conditional heterozygous deletion of Notch1 in the second heart field (SHF) lineage recapitulates exacerbated aortic root dilation, establishing an SHF lineage-specific role for Notch1 in ascending aortic aneurysm. Notch1 heterozygous mice (129S6 background), SHF lineage-specific Notch1 conditional deletion, Marfan syndrome mouse model crossbreeding, RNA sequencing of aortic root JCI insight Medium 29093270
2017 Notch1 is required for intermittent hypoxia (IH)-enhanced hippocampal neurogenesis in vivo; IH activates Notch1 signaling in wild-type mice, and Notch1 heterozygous (N+/-) mice fail to upregulate Notch1 activity after IH and show blocked IH-enhanced NSC proliferation, newborn neuron survival/migration, and spine morphogenesis. Notch1 heterozygous mice, intermittent hypoxia protocol, BrdU incorporation, immunohistochemistry for neurogenesis markers Neurobiology of disease Medium 24368168
2021 Cardiac-specific Notch1 deletion causes multiple structural cardiac defects and embryonic lethality; Notch1 is expressed and activated in the myocardium at multiple stages; Notch1 or RBPJk deletion in NFP double-knockout (MDKO) mice partially rescues defects in cardiac progenitor cell differentiation, cardiomyocyte proliferation, and trabecular morphogenesis but not structural defects, indicating NFPs regulate cardiac development through both Notch1-dependent and Notch1-independent mechanisms. Cardiac-specific Notch1 and RBPJk knockout mice, Notch reporter lines, RNAScope, Numb/Numbl/Notch1/RBPJk triple knockout, phenotype comparison Cells Medium 34571841

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. The Journal of investigative dermatology 282 24662767
2017 Endothelial Notch1 Activity Facilitates Metastasis. Cancer cell 250 28238683
2017 NOTCH1 is a mechanosensor in adult arteries. Nature communications 248 29158473
2008 Notch1 is an effector of Akt and hypoxia in melanoma development. The Journal of clinical investigation 170 18924608
2009 The role of NOTCH1 signaling in T-ALL. Hematology. American Society of Hematology. Education Program 152 20008221
2014 Mutations in NOTCH1 cause Adams-Oliver syndrome. American journal of human genetics 150 25132448
1996 Modulated expression of notch1 during thymocyte development. Blood 133 8704256
2017 Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 113 28314854
2015 Lyso-Gb3 activates Notch1 in human podocytes. Human molecular genetics 109 26206887
2001 Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells. Leukemia & lymphoma 103 11699411
2021 An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness. Nature communications 92 33976158
2015 Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. The Journal of experimental medicine 92 26552708
2020 Notch1 in Cancer Therapy: Possible Clinical Implications and Challenges. Molecular pharmacology 89 32913140
2015 The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (Cambridge, England) 76 26062937
2016 Notch signaling in lung diseases: focus on Notch1 and Notch3. Therapeutic advances in respiratory disease 74 27378579
2008 Notch1 signaling and regulatory T cell function. Journal of immunology (Baltimore, Md. : 1950) 74 18292500
2014 Notch1 mutations are drivers of oral tumorigenesis. Cancer prevention research (Philadelphia, Pa.) 72 25406187
2011 MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. Cancer biology & therapy 72 21743299
2018 NOTCH1 Aberrations in Chronic Lymphocytic Leukemia. Frontiers in oncology 69 29998084
2008 Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. Clinical cancer research : an official journal of the American Association for Cancer Research 66 18765521
2011 DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation. The Journal of biological chemistry 65 21398698
2015 Notch1 is pan-endothelial at the onset of flow and regulated by flow. PloS one 64 25830332
2020 Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. The Journal of biological chemistry 59 32820046
2023 Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis. American journal of respiratory and critical care medicine 58 36047984
2017 Notch1 regulates tongue cancer cells proliferation, apoptosis and invasion. Cell cycle (Georgetown, Tex.) 57 29117785
2015 Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development. Diabetes 57 26293507
2014 Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer. The Journal of clinical investigation 57 24743148
1995 Differential expression of Notch1 and Notch2 in developing and adult mouse brain. Brain research. Molecular brain research 55 7609614
2017 Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proceedings of the National Academy of Sciences of the United States of America 52 28174276
2017 Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI insight 50 29093270
2022 Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circulation research 49 36583388
2017 Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell death and differentiation 46 28475172
2015 Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction. Arteriosclerosis, thrombosis, and vascular biology 46 26023079
2002 Notch1 and Jagged1 expression by the developing pulmonary vasculature. Developmental dynamics : an official publication of the American Association of Anatomists 44 12242716
2014 Variants in the NOTCH1 gene in patients with aortic coarctation. Congenital heart disease 41 24418111
2007 The Notch1/c-Myc pathway in T cell leukemia. Cell cycle (Georgetown, Tex.) 41 17404512
2023 A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer. Cell discovery 39 37714834
2019 Altered expression of Notch1 in Alzheimer's disease. PloS one 38 31770379
2017 Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Human molecular genetics 38 28498977
2016 Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget 38 27191259
2014 Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture. Bone 37 24508387
2011 Notch1 expression is upregulated in glioma and is associated with tumor progression. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 37 21251836
2021 Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. American journal of physiology. Cell physiology 36 34878922
2023 SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1. Cardiovascular diabetology 35 38017499
2020 Modulation of Notch1 signaling regulates bone fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 35 32141629
2018 Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes. Cardiovascular research 35 29186476
2008 Notch1 expression in colorectal carcinoma determines tumor differentiation status. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 35 18777195
2021 Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria. Circulation research 34 33435713
2019 Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis. Cell communication and signaling : CCS 34 31718671
2018 Notch1 provides myocardial protection by improving mitochondrial quality control. Journal of cellular physiology 34 30515819
2015 Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling. BMB reports 34 26058398
2007 The role of chorionic gonadotropin and Notch1 in implantation. Journal of assisted reproduction and genetics 34 17616802
2017 Notch1 ablation radiosensitizes glioblastoma cells. Oncotarget 33 29152141
2016 Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression. Clinical cancer research : an official journal of the American Association for Cancer Research 33 26847059
2015 Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. International journal of oncology 33 25955618
2014 Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell cycle (Georgetown, Tex.) 32 24801890
2013 Notch1 mediates postnatal neurogenesis in hippocampus enhanced by intermittent hypoxia. Neurobiology of disease 32 24368168
2004 p53 regulates thymic Notch1 activation. European journal of immunology 32 14991602
2014 NOTCH1, NOTCH3, NOTCH4, and JAG2 protein levels in human endometrial cancer. Medicina (Kaunas, Lithuania) 31 25060200
2019 Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells. Oncogene 30 31616059
2017 Leukemia-specific delivery of mutant NOTCH1 targeted therapy. The Journal of experimental medicine 30 29158376
2019 Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research 29 31578228
2017 NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL. BioMed research international 28 28246602
2017 Glycogen synthase kinase 3β inhibition enhances Notch1 recycling. Molecular biology of the cell 27 29237816
2014 Notch-1 mediates endothelial cell activation and invasion in psoriasis. Experimental dermatology 27 24330353
2020 Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling. Cardiovascular drugs and therapy 26 32157565
2020 Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds. Life science alliance 26 33109684
2016 Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma. Oncotarget 26 27167202
2015 PI3K/AKT signaling inhibits NOTCH1 lysosome-mediated degradation. Genes, chromosomes & cancer 26 26052821
2020 Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis. Neuroscience research 25 33309869
2022 CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype. Journal of experimental & clinical cancer research : CR 24 35172861
2015 Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome. Endocrine-related cancer 24 25979380
2015 Notch1 endocytosis is induced by ligand and is required for signal transduction. Biochimica et biophysica acta 24 26522918
2017 The Notch-1 receptor in prostate tumorigenesis. Cancer treatment reviews 23 28457880
2015 Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis. Cancer research 23 26294213
2021 Notch1 signaling enhances collagen expression and fibrosis in mouse uterus. BioFactors (Oxford, England) 22 34320265
2017 Expression of Notch1 and Numb in small cell lung cancer. Oncotarget 22 28060745
2021 Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Hypertension (Dallas, Tex. : 1979) 21 34739767
2020 α5-nAChR modulates melanoma growth through the Notch1 signaling pathway. Journal of cellular physiology 20 31907929
2017 Both Notch1 and its ligands in B cells promote antibody production. Molecular immunology 20 28863329
2010 Up-regulated expression of Notch1 and Jagged1 in human colon adenocarcinoma. Pathologie-biologie 20 21145176
2003 Fine-tuning Notch1 activation by endocytosis and glycosylation. Seminars in immunology 20 12681946
2019 PLK1 targets NOTCH1 during DNA damage and mitotic progression. The Journal of biological chemistry 19 31597699
2018 FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma. International journal of molecular medicine 19 29620159
2018 Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis. Experimental cell research 19 30266659
2012 P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis. Frontiers in bioscience (Elite edition) 18 22652674
2021 Notch1 haploinsufficiency in mice accelerates adipogenesis. Scientific reports 17 34408185
2019 High-Dose Radiation Increases Notch1 in Tumor Vasculature. International journal of radiation oncology, biology, physics 17 31759078
2017 Developmental changes in Notch1 and NLE1 expression in a genetic model of absence epilepsy. Brain structure & function 17 28210849
2020 A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation. Cellular and molecular gastroenterology and hepatology 16 33189893
2018 Chemotactic Cues for NOTCH1-Dependent Leukemia. Frontiers in immunology 16 29666622
2022 Optogenetic control of NOTCH1 signaling. Cell communication and signaling : CCS 15 35585598
2022 Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond. Cancers 15 35740661
2016 Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma. Histopathology 15 27542980
2016 Notch1 in oral squamous cell carcinoma. Histology and histopathology 15 27615693
2021 Notch1 switches progenitor competence in inducing medulloblastoma. Science advances 14 34162555
2020 Inhibition of the Notch1 pathway induces peripartum cardiomyopathy. Journal of cellular and molecular medicine 14 32529705
2018 Src kinase phosphorylates Notch1 to inhibit MAML binding. Scientific reports 14 30341382
2017 Notch1 Overexpression Correlates to Improved Survival in Cancer of the Oropharynx. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 14 28195818
2021 The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis. Cells 13 34571841

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