Affinage

SRGN

Serglycin · UniProt P10124

Length
158 aa
Mass
17.7 kDa
Annotated
2026-04-28
92 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SRGN (serglycin) is a secreted proteoglycan that functions as an extracellular signaling molecule activating multiple receptor-mediated pathways to drive inflammation, tumor invasion, stemness, and chemoresistance. Secreted SRGN engages CD44 to activate NF-κB signaling in microglia and CREB1-dependent TGFβ2 transcription in breast cancer, and signals through ITGA5/FAK to promote YAP nuclear translocation and YAP/TEAD1-dependent transcriptional programs including HDAC2 and CRISPLD2, establishing feed-forward circuits that sustain tumor stemness and metastasis (PMID:32292495, PMID:28692037, PMID:38287411, PMID:40384866). SRGN also activates NF-κB and MAPK cascades to induce proinflammatory cytokines (CCL2, TNF-α, IL-6, CCL3) in diverse cell types including Sertoli cells, endothelial cells, and chondrocytes (PMID:41910735, PMID:34524427, PMID:39067006). SRGN transcription is directly regulated by HIF-1α, Smad3, and CREB1 binding to its promoter, and its mRNA is post-transcriptionally stabilized by ALKBH5-mediated m6A demethylation (PMID:30121667, PMID:35562411, PMID:41910735).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2017 High

    Establishing that secreted SRGN is not merely a structural proteoglycan but an autocrine/paracrine signaling molecule that engages CD44 to activate CREB1 and TGFβ2, forming a feed-forward loop with Smad3-driven SRGN transcription to promote EMT and invasion.

    Evidence ChIP for Smad3 on SRGN promoter, shRNA knockdown, recombinant protein treatment, and in vivo metastasis model in TNBC cells

    PMID:28692037

    Open questions at the time
    • CD44-CREB1 signaling intermediates not fully mapped
    • Glycosaminoglycan chain requirement for CD44 engagement not tested
    • Feed-forward loop dynamics not quantified
  2. 2018 Medium

    Identifying HIF-1α as a direct transcriptional activator of SRGN through a hypoxia response element, linking SRGN upregulation to the tumor hypoxic microenvironment.

    Evidence ChIP showing HIF-1α binding to SRGN promoter, shRNA knockdown, and transwell assays in colorectal cancer cells

    PMID:30121667

    Open questions at the time
    • Single-lab study without independent replication
    • Contribution of hypoxia-induced SRGN relative to other HIF-1α targets not dissected
    • No in vivo hypoxia validation
  3. 2019 Medium

    Demonstrating post-transcriptional regulation of SRGN via a ceRNA mechanism (SNHG3/miR-758-3p/SRGN axis), showing that SRGN levels can be modulated by non-coding RNA networks in AML.

    Evidence miRNA target validation, genetic rescue epistasis with SNHG3 knockdown and miR-758-3p inhibition in AML cells

    PMID:31452272

    Open questions at the time
    • In vitro only with no in vivo validation
    • Direct miR-758-3p binding site on SRGN 3′UTR not confirmed by mutation
    • Physiological relevance to AML progression unclear
  4. 2020 High

    Deciphering the SRGN/ITGA5/FAK/CREB/YAP/HDAC2 signaling cascade that establishes a feed-forward transcriptional circuit driving chemoresistance and stemness in breast cancer, and separately showing that PKA/CREB mediates shear-stress-induced SRGN expression in endothelial cells.

    Evidence Co-IP, ChIP-qPCR, luciferase reporters, epistasis via YAP knockdown/overexpression, xenograft models (breast cancer); PKA/CREB inhibitors and carotid ligation model (endothelial cells)

    PMID:32292495 PMID:32712749

    Open questions at the time
    • ITGA5 as direct SRGN receptor not validated by binding assay
    • Relative contribution of FAK vs other integrin-proximal kinases unknown
    • PKA/CREB-SRGN link in endothelial cells relies on pharmacological inhibition
  5. 2022 High

    Mapping a STAT3/FoxO1/miR-148a-5p/CREB1 regulatory cascade converging on SRGN promoter activation, and confirming SRGN's role in immune evasion through PD-L1 upregulation and proinflammatory cytokine induction in lung adenocarcinoma.

    Evidence EMSA, ChIP, dual-luciferase reporter, and xenograft models (NPC); siRNA knockdown with cytokine profiling and syngeneic models (LUAD)

    PMID:34524427 PMID:35562411

    Open questions at the time
    • SRGN-to-PD-L1 signaling intermediates not identified
    • NNMT-DNA methylation-SRGN link is correlative without direct demethylation rescue
    • Whether STAT3 axis and HIF-1α axis converge on SRGN promoter simultaneously is unknown
  6. 2024 High

    Establishing CD44 as a genetically validated SRGN receptor in vivo through Cd44-knockout rescue of SRGN-driven neuroinflammation, and identifying SRGN-dependent CCL3 secretion as a macrophage chemoattractant mechanism in chondrocytes.

    Evidence Srgn-KO and Cd44-KO mice with MCAO stroke model and recombinant SRGN injection; siRNA knockdown with transwell macrophage migration in chondrocyte co-culture

    PMID:38287411 PMID:39067006

    Open questions at the time
    • Glycosaminoglycan chain versus core protein requirement for CD44 binding not dissected
    • CCL3 induction mechanism downstream of SRGN not identified
    • Chondrocyte findings are in vitro only
  7. 2025 Medium

    Extending the SRGN/YAP axis to hepatocellular carcinoma and identifying CRISPLD2 as a direct YAP/TEAD1 transcriptional target mediating SRGN-driven HCC metastasis and stemness.

    Evidence Reporter assays for YAP/TEAD1 on CRISPLD2 promoter, nuclear fractionation, knockdown/overexpression epistasis, and in vivo HCC models

    PMID:40384866

    Open questions at the time
    • Single lab; receptor mediating SRGN-to-YAP in HCC not identified
    • Whether CRISPLD2 is the principal YAP effector or one of many targets is unclear
    • No structural data on SRGN-receptor interaction
  8. 2026 Medium

    Revealing epitranscriptomic regulation of SRGN through ALKBH5-mediated m6A demethylation that stabilizes Srgn mRNA, connecting lipotoxic stress to NF-κB/MAPK activation and blood-testis barrier disruption.

    Evidence m6A methylation assay, RNA stability assay, ALKBH5 knockdown rescue, tight junction integrity assays in Sertoli cells

    PMID:41910735

    Open questions at the time
    • Specific m6A sites on Srgn mRNA not mapped
    • In vivo fertility consequences not assessed
    • Whether ALKBH5 regulation of SRGN operates in other cell types is unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity and structural basis of SRGN's interaction with its receptors (CD44, ITGA5) — including whether the glycosaminoglycan chains or core protein mediate binding — remain unresolved, and no structural model of SRGN-receptor complexes exists.
  • No crystal or cryo-EM structure of SRGN or SRGN-receptor complex
  • GAG chain versus core protein contribution to signaling not dissected
  • Unified model integrating multiple receptor inputs (CD44, ITGA5) is lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0060089 molecular transducer activity 3
Localization
GO:0005576 extracellular region 6
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1643685 Disease 6 R-HSA-168256 Immune System 3
Partners
ALKBH5CD44CREB1HDAC2ITGA5SMAD3TEAD1YAP1

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 Secreted SRGN triggers ITGA5/FAK/CREB signaling to enhance YAP transcription; reciprocally, YAP promotes SRGN transcription in a TEAD1-dependent manner, forming a feed-forward circuit. The YAP/RUNX1 complex then promotes HDAC2 transcription to induce chemoresistance and stemness in breast cancer cells. Ectopic YAP expression restored effects of SRGN knockdown, and YAP knockdown rescued SRGN overexpression effects, establishing epistatic pathway order. Co-immunoprecipitation, luciferase reporter assay, ChIP-qPCR, shRNA knockdown, flow cytometry, mammosphere assay, in vivo xenograft, immunofluorescence Theranostics High 32292495
2017 Secreted SRGN protein activates CD44/CREB1 signaling to increase TGFβ2 expression and secretion, promoting epithelial-to-mesenchymal transition and invasion in triple-negative breast cancer cells. Conversely, TGFβ2 activates Smad3, which binds the SRGN promoter to upregulate SRGN transcription, establishing an autocrine/paracrine feed-forward regulatory loop. shRNA knockdown, recombinant protein treatment, ChIP assay, transwell invasion assay, in vivo metastasis model, Western blot, qPCR Oncogenesis High 28692037
2024 SRGN signals through its receptor CD44 on microglia to activate NF-κB signaling and increase glycolysis, amplifying proinflammatory microglial activation following ischemic stroke. Genetic deletion of Cd44 partially rescued rSRGN-induced excess neuroinflammation and ischemic brain injury in mice. Srgn and Cd44 knockout mice, middle cerebral artery occlusion model, stereotactic injection of recombinant SRGN, Iba1 immunostaining, cytokine measurement, TTC staining, LPS stimulation in vitro Journal of neuroinflammation High 38287411
2018 HIF-1α directly binds a hypoxia response element in the SRGN promoter to transcriptionally upregulate SRGN, and SRGN overexpression promotes colorectal cancer cell migration and invasion, placing SRGN as a direct downstream effector of hypoxia signaling in colorectal cancer metastasis. Chromatin immunoprecipitation (ChIP), qRT-PCR, Western blot, transwell migration/invasion assay, shRNA knockdown Cellular physiology and biochemistry Medium 30121667
2022 STAT3 regulates SRGN expression in nasopharyngeal carcinoma through a FoxO1-miR-148a-5p-CREB1 axis: FoxO1 binds and activates miR-148a-5p transcription; miR-148a-5p suppresses CREB1; CREB1 directly binds the SRGN promoter to drive SRGN expression. SRGN knockdown suppressed NPC tumor progression in vitro and in vivo. EMSA, ChIP, dual-luciferase reporter assay, RIP assay, qRT-PCR, Western blot, xenograft tumor model, Transwell assay Laboratory investigation High 35562411
2022 SRGN regulates PD-L1 expression as well as proinflammatory cytokines (IL-6, IL-8, CXCL1) in lung adenocarcinoma cells, and increases migratory and invasive properties of LUAD cells and fibroblasts and enhances angiogenesis. SRGN expression is induced by DNA demethylation resulting from NNMT-mediated impairment of methionine metabolism. siRNA knockdown, syngeneic mouse model, cytokine measurement, migration/invasion assays, proteomic and metabolomic analyses, immunohistochemistry Journal of the National Cancer Institute Medium 34524427
2020 Low shear stress enhances SRGN expression in human umbilical vein endothelial cells via the PKA/CREB-dependent signaling pathway, and SRGN high-expression cells show increased Ki67+ cell proportion and higher nitric oxide concentration, implicating SRGN in endothelial cell proliferation in response to shear stress. In vitro shear stress loading in HUVECs, in vivo partial carotid artery ligation in mice, PKA/CREB inhibitor experiments, Ki67 staining, NO concentration measurement, bioinformatics analysis of zebrafish high-throughput data Molecular and cellular biochemistry Medium 32712749
2019 SNHG3 (lncRNA) modulates SRGN expression by competitively sponging miR-758-3p; miR-758-3p targets SRGN mRNA; knockdown of SNHG3 decreased SRGN and inhibited AML cell proliferation while inducing apoptosis, and these effects were rescued by miR-758-3p suppression or SRGN overexpression. siRNA knockdown, luciferase reporter assay (implied), qRT-PCR, Western blot, flow cytometry for apoptosis, CCK-8 proliferation assay, miRNA target validation Journal of cellular biochemistry Medium 31452272
2025 SRGN activates YAP nuclear translocation in hepatocellular carcinoma cells, and YAP/TEAD1 complex directly targets the CRISPLD2 promoter to upregulate CRISPLD2, establishing a SRGN/YAP/CRISPLD2 axis that promotes HCC metastasis and stemness maintenance in an autocrine manner. In vitro migration assays, in vivo experiments, reporter assays, knockdown and overexpression of SRGN/YAP/CRISPLD2, nuclear/cytoplasmic fractionation for YAP localization International journal of biological sciences Medium 40384866
2024 SRGN in chondrocytes promotes recruitment of THP-1-derived macrophages by upregulating CCL3 expression and secretion; siRNA-mediated SRGN knockdown reduced CCL3 and impaired macrophage migration in a transwell co-culture model. siRNA knockdown, plasmid overexpression, conditioned media co-culture, transwell macrophage migration assay, qPCR, Western blot, ELISA for CCL3 Connective tissue research Medium 39067006
2026 ALKBH5-mediated m6A demethylation of Srgn mRNA enhances its stability, leading to increased SRGN protein in Sertoli cells exposed to palmitic acid. Elevated SRGN then activates NF-κB and MAPK pathways, upregulating Ccl2 and TNF-α, thereby disrupting blood-testis barrier integrity. Suppressing Alkbh5 alleviated this BTB disruption. siRNA knockdown of Alkbh5, Srgn overexpression and knockdown, m6A methylation assay, RNA stability assay, NF-κB and MAPK pathway analysis, Western blot, tight junction integrity assays in TM4 and primary Sertoli cells Cellular and molecular life sciences Medium 41910735

Source papers

Stage 0 corpus · 92 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Molecular cell 458 18571452
2008 A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis. Current biology : CB 222 18501605
2019 Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance. Cell 194 31178117
2009 Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell 122 19766573
2003 A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nature neuroscience 110 12730698
2015 PPG neurons of the lower brain stem and their role in brain GLP-1 receptor activation. American journal of physiology. Regulatory, integrative and comparative physiology 84 26290108
2001 Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells. Oncogene 77 11244505
2005 Comparison of coatings from reactive star shaped PEG-stat-PPG prepolymers and grafted linear PEG for biological and medical applications. Biomacromolecules 71 15762665
2020 SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression. Theranostics 64 32292495
1998 The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. FEBS letters 61 9781666
2018 Inhibitory effect of surface pre-reacted glass-ionomer (S-PRG) eluate against adhesion and colonization by Streptococcus mutans. Scientific reports 60 29568011
2011 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). The Journal of biological chemistry 58 21454492
1997 Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Molecular endocrinology (Baltimore, Md.) 53 9092801
2024 SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury. Journal of neuroinflammation 52 38287411
2004 Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. The European journal of neuroscience 51 14750979
2017 SRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer. Oncogenesis 50 28692037
2016 Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO molecular medicine 45 26671989
1993 The gene PPG encodes a novel yeast protein phosphatase involved in glycogen accumulation. The Journal of biological chemistry 44 7678255
2023 Multiple-Ion Releasing Bioactive Surface Pre-Reacted Glass-Ionomer (S-PRG) Filler: Innovative Technology for Dental Treatment and Care. Journal of functional biomaterials 43 37103326
2016 PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. Developmental cell 43 27453502
1996 PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. Cancer research 43 8653710
2022 SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas. Journal of the National Cancer Institute 42 34524427
2017 Identification of novel follicular dendritic cell sarcoma markers, FDCSP and SRGN, by whole transcriptome sequencing. Oncotarget 41 28145886
2012 Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria. International journal of dentistry 39 22693508
2016 Structure-property relationship for in vitro siRNA delivery performance of cationic 2-hydroxypropyl-β-cyclodextrin: PEG-PPG-PEG polyrotaxane vectors. Biomaterials 38 26826298
1998 The proliferation-associated early response gene p22/PRG1 is a novel p53 target gene. Oncogene 38 9627114
2018 SRGN Promotes Colorectal Cancer Metastasis as a Critical Downstream Target of HIF-1α. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36 30121667
2019 lncRNA SNHG3 facilitates acute myeloid leukemia cell growth via the regulation of miR-758-3p/SRGN axis. Journal of cellular biochemistry 34 31452272
2013 5-Fluorouracil-loaded PLA/PLGA PEG-PPG-PEG polymeric nanoparticles: formulation, in vitro characterization and cell culture studies. Drug development and industrial pharmacy 33 23596973
1999 Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cells. Pancreas 32 10231843
1999 The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo. Biochemical and biophysical research communications 32 10448082
2010 Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein. The Biochemical journal 29 20653564
2008 ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats. Toxicology letters 29 19059322
1994 Mutations in PRG1, a yeast proteasome-related gene, cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene. Proceedings of the National Academy of Sciences of the United States of America 29 8134345
2020 PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice. Molecular metabolism 28 32446875
2021 PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus. International journal of biological sciences 26 34671215
2012 Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7. Arthritis research & therapy 24 22490392
2000 Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage. Neuropharmacology 24 10699457
2006 Isolation of bacteria able to grow on both polyethylene glycol (PEG) and polypropylene glycol (PPG) and their PEG/PPG dehydrogenases. Applied microbiology and biotechnology 23 17043822
2022 Development, validation, and reproducibility of the pullback pressure gradient (PPG) derived from manual fractional flow reserve pullbacks. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 22 35233906
2020 The role of SRGN in the survival and immune infiltrates of skin cutaneous melanoma (SKCM) and SKCM-metastasis patients. BMC cancer 21 32370744
2017 Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders. Behavioural brain research 21 28843862
2021 A Comparative Study of Cytotoxicity of PPG and PEG Surface-Modified 2-D Ti3C2 MXene Flakes on Human Cancer Cells and Their Photothermal Response. Materials (Basel, Switzerland) 20 34442891
2020 Binary CorNET: Accelerator for HR Estimation From Wrist-PPG. IEEE transactions on biomedical circuits and systems 17 32746344
2022 Hyaluronic acid-g-PPG and PEG-PPG-PEG hybrid thermogel for prolonged gel stability and sustained drug release. Carbohydrate polymers 16 35698385
2011 Synthesis, characterizations and biocompatibility of alternating block polyurethanes based on P3/4HB and PPG-PEG-PPG. Journal of biomedical materials research. Part A 16 21538829
2000 (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist. Bioorganic & medicinal chemistry letters 15 10866390
2016 Distinct Contributions of Enzymic Functional Groups to the 2',3'-Cyclic Phosphodiesterase, 3'-Phosphate Guanylylation, and 3'-ppG/5'-OH Ligation Steps of the Escherichia coli RtcB Nucleic Acid Splicing Pathway. Journal of bacteriology 14 26858100
1994 Physicochemical characterization of PEG-PPG conjugated human urokinase. Biochimica et biophysica acta 14 8123669
2008 Prg1 is regulated by the basic helix-loop-helix transcription factor Math2. Journal of neurochemistry 13 18643870
2022 STAT3 regulates SRGN and promotes metastasis of nasopharyngeal carcinoma through the FoxO1-miR-148a-5p-CREB1 axis. Laboratory investigation; a journal of technical methods and pathology 12 35562411
2019 Optimization of Degradation Conditions with PRG, a Polysaccharide from Phellinus ribis, by RSM and the Neuroprotective Activity in PC12 Cells Damaged by Aβ25-35. Molecules (Basel, Switzerland) 12 31434196
2005 Dynamic pattern of mRNA expression of plasticity-related gene-3 (PRG-3) in the mouse cerebral cortex during development. Brain research bulletin 12 16144631
1995 Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein. The Biochemical journal 12 7741717
2020 SRGN, a new identified shear-stress-responsive gene in endothelial cells. Molecular and cellular biochemistry 11 32712749
1987 Biodehalogenation of bromotrichloromethane and 1,2-dibromo-3-chloropropane by Pseudomonas putida PpG-786. Biotechnology and bioengineering 10 18576369
1975 [Isolation and characterization of a high molecular weight placental protein (PPg)(author's transl)]. Archiv fur Gynakologie 10 50830
2023 Neuroprotective effects of PRG on Aβ25-35-induced cytotoxicity through activation of the ERK1/2 signaling pathway. Journal of ethnopharmacology 9 37120057
2021 Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology 9 33581143
2002 Crystallization of the collagen-like polypeptide (PPG)10 aboard the International Space Station. 1. Video observation. Acta crystallographica. Section D, Biological crystallography 8 12351887
2024 PRG ameliorates cognitive impairment in Alzheimer's disease mice by regulating β-amyloid and targeting the ERK pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 7 38763005
2002 Crystallization of the collagen-like polypeptide (PPG)10 aboard the International Space Station. 2. Comparison of crystal quality by X-ray diffraction. Acta crystallographica. Section D, Biological crystallography 7 12351888
2022 PRG-1 prevents neonatal stimuli-induced persistent hyperalgesia and memory dysfunction via NSF/Glu/GluR2 signaling. iScience 6 36093041
2024 Transdentinal effects of S-PRG fillers on odontoblast-like cells. Dental materials : official publication of the Academy of Dental Materials 5 38871524
2021 Effects of multi-components released from S-PRG filler on the activities of human dental pulp-derived stem cells. Dental materials journal 5 34234045
2015 NT-3 protein levels are enhanced in the hippocampus of PRG1-deficient mice but remain unchanged in PRG1/LPA2 double mutants. Neuroscience letters 5 26687273
2014 PPG peptide nucleic acids that promote DNA guanine quadruplexes. Chembiochem : a European journal of chemical biology 5 25044379
2025 SRGN-mediated reactivation of the YAP/CRISPLD2 axis promotes aggressiveness of hepatocellular carcinoma. International journal of biological sciences 4 40384866
2024 SRGN promotes macrophage recruitment through CCL3 in osteoarthritis. Connective tissue research 4 39067006
2014 The influences of PRG-1 on the expression of small RNAs and mRNAs. BMC genomics 4 24884413
2023 Mutations in plasticity-related-gene-1 (PRG-1) protein contribute to hippocampal seizure susceptibility and modify epileptic phenotype. Cerebral cortex (New York, N.Y. : 1991) 3 36977636
2023 Efficacy of a recombinant Lactobacillus plantarum Lp-pPG-Malt as an oral vaccine candidate against Aeromonas hydrophila infection in crucian carp. Fish & shellfish immunology 3 37030560
2023 Lc-pPG-612-OmpU-CTB: A promising oral vaccine for protecting Carassius auratus against Vibrio mimicus infection. Fish & shellfish immunology 3 37481101
2022 Cotransplantation with RADA16-PRG-Self-Assembled Nanopeptide Scaffolds, Bone Mesenchymal Stem Cells and Brain-Derived Neurotrophic Factor-Adeno-Associated Virus Promote Functional Repair After Acute Spinal Cord Injury in Rats. Journal of biomedical nanotechnology 3 35180916
2008 Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis. Pediatric blood & cancer 3 18000860
2005 PPG: online generation of protein pictures and animations. Nucleic acids research 3 15980481
1998 p22/PACAP response gene 1 (PRG1): a putative target gene for the tumor suppressor p53. Annals of the New York Academy of Sciences 3 9927993
2024 Bioactivity of human dental pulp-derived stem cells with boron-controlled S-PRG filler eluate by anion exchange. Dental materials journal 2 38432951
2022 Efficacy and Safety of Percutaneous Radiological Gastrostomy (PRG) as a Rescue Measure for Enteral Feeding in Patients with Advanced Head, Neck, and Upper Digestive Malignancies. The Indian journal of radiology & imaging 2 36451943
2021 Effects of S-PRG filler eluate on MMP-1 and MMP-3 secretion by human gingival fibroblasts. Dental materials journal 2 34602584
2020 Heart-rate tuned comb filters for processing photoplethysmogram (PPG) signals in pulse oximetry. Journal of clinical monitoring and computing 2 32556842
2011 PRG-1 transcriptional regulation independent from Nex1/Math2-mediated activation. Cellular and molecular life sciences : CMLS 2 21805347
2025 Therapeutic effect of novel drug candidate, PRG-N-01, on NF2 syndrome-related tumor. Neuro-oncology 1 39731295
2025 PRG-1 Relieves Neonatal Stimuli-Induced Hyperalgesia and Anxiety via Stage-Specific Synapse Remodeling. CNS neuroscience & therapeutics 1 40820861
2025 Integrating transfer learning with scalogram analysis for blood pressure estimation from PPG signals. Scientific reports 1 41224941
2024 PrG protects postovulatory oocytes aging in mice through the putrescine pathway. Biochemical and biophysical research communications 1 39053107
2003 Crystallization of the collagen-like polypeptide (PPG)10 aboard the International Space Station. 3. Analysis of residual acceleration-induced motion. Acta crystallographica. Section D, Biological crystallography 1 12657808
2026 ALKBH5 facilitates Srgn stability via m6A demethylation to disrupt blood-testis barrier integrity in the high-fat diet mice. Cellular and molecular life sciences : CMLS 0 41910735
2025 MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway. Proteome science 0 39915794
2025 Bioactive caries-preventing effects of mineral ions released from surface pre-reacted glass-ionomer (S-PRG) filler on oral biofilm. Archives of oral biology 0 40946583
2025 Real-Time Subject-Specific Predictive Modeling of PPG Signals for Artifact-Resilient SpO2 Estimation Under Hypoxia. Sensors (Basel, Switzerland) 0 41374551
2024 What Remote PPG Oximetry Tells Us about Pulsatile Volume? Biomedicines 0 39200248