- Length
- 224 aa
- Mass
- 24.4 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
28 papers cited in narrative
28 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Insufficient on-target evidence to synthesize a narrative — discovery timeline does not match the canonical SRA1 protein.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 28 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 1999 | SRA (Steroid Receptor RNA Activator) was identified as a novel transcriptional coactivator that functions as an RNA transcript rather than a protein; it is selective for steroid hormone receptors, mediates transactivation via their amino-terminal AF-1 activation function, and exists in distinct ribonucleoprotein complexes including one containing SRC-1. Evidence that SRA functions as RNA: coactivation persists in the presence of cycloheximide and SRA mutants with multiple translational stop signals retain coactivator activity. | Biochemical fractionation, ribonucleoprotein complex isolation, functional reporter assays with cycloheximide treatment, translational stop-signal mutagenesis | Cell | High | 10199399 |
| 2001 | The RNA-binding DEAD-box proteins p72/p68 function as estrogen receptor alpha (ERα) coactivators through the AF-1 domain by associating with a coactivator complex containing SRA and SRC-1/TIF2. p72/p68 interact with the AD2 domain of SRC-1/TIF2 family proteins and the ERα A/B domain, and co-immunoprecipitate with estrogen-bound ERα in MCF7 cells. Combination of p72/p68 with SRA and TIF2 produces synergistic estrogen-induced transactivation of ERα. | Co-immunoprecipitation from MCF7 cells and HeLa nuclear extracts, transient transfection reporter assays, immunofluorescence co-localization | The EMBO journal | High | 11250900 |
| 2003 | SRA coactivates ERα in a ligand-independent manner through the AF-1 domain, requiring an intact serine-118 (S118) residue in ERα AF-1. MAPK activation induces ligand-independent coactivation of ERα by SRA; activated H-Ras (H-RasV12) cannot rescue S118 ERα mutant activity, indicating that MAPK-mediated phosphorylation of S118 participates in SRA's AF-1-dependent effect. SRA does not coactivate ERβ via AF-1 in the same manner, demonstrating isoform selectivity. | Transient transfection reporter assays, site-directed mutagenesis of ERα S118, co-expression with activated Ras and MAPK pathway components | The Journal of steroid biochemistry and molecular biology | Medium | 12943696 |
| 2003 | In Drosophila cells, Sra-1 (ortholog of human CYFIP1/SRA1 WAVE complex subunit), together with Abi and Kette (Nap1), protects SCAR/WAVE from proteasome-mediated degradation and is critical for SCAR localization and for Arp2/3-dependent actin protrusion generation. RNAi-mediated removal of Sra-1, Abi, or Kette abolishes dynamic protrusions, demonstrating these proteins are essential components of the SCAR regulatory complex downstream of Rac and Cdc42. | RNAi screen in Drosophila adherent cells, immunofluorescence, proteasome inhibitor experiments, epistasis analysis | Current biology : CB | High | 14588242 |
| 2004 | Sra-1 (CYFIP/PIR121) and Nap1 are constitutive components of a WAVE2/Abi-1-containing complex that links Rac1 signaling to site-directed actin assembly and lamellipodia formation. RNA interference removal of Sra-1 or Nap1 abrogates Rac-dependent lamellipodia induced by growth factor stimulation or aluminum fluoride treatment, and microinjection of constitutively active Rac fails to restore lamellipodia in cells lacking either protein. Sra-1, Nap1, WAVE2, and Abi-1 translocate to tips of membrane protrusions after active Rac microinjection. | RNAi knockdown, microinjection of constitutively active Rac1, immunofluorescence, co-immunoprecipitation of complex components | The EMBO journal | High | 14765121 |
| 2004 | The Arabidopsis PIROGI gene encodes a functional ortholog of the human WAVE complex subunit SRA1 (CYFIP1). PIROGI/SRA1 directly interacts with the small GTPase ATROP2 with isoform specificity and selectivity for active (GTP-bound) forms. Both PIROGI and human SRA1 are functionally interchangeable and display identical physical interactions with RHO family GTPases and the WAVE complex subunit NAP125, indicating deeply conserved molecular function in ARP2/3-dependent actin regulation. | Genetic complementation, yeast two-hybrid, pull-down assays with active/inactive GTPase forms, phenotypic analysis of pir mutants | Development (Cambridge, England) | High | 15294869 |
| 2004 | Drosophila Sra-1 interacts physically with Kette (Nap1) in vivo, and both proteins stabilize each other. Sra-1 is expressed in neuronal growth cones; RNAi knockdown of sra-1 in photoreceptor neurons causes stalling of axonal growth, and knockdown in motoneurons produces abnormal neuromuscular junctions similar to kette hypomorphic mutants. A membrane-bound Sra-1 lacking the Kette-binding domain phenocopies loss of function, indicating Sra-1 function is mediated through Kette and controls F-actin cytoskeleton in a Wasp-dependent manner. | In vivo co-immunoprecipitation, RNAi in specific neuronal subtypes, dominant-negative Sra-1 construct lacking Kette-binding domain, confocal imaging of neuromuscular junctions | Development (Cambridge, England) | High | 15269173 |
| 2005 | CRMP-2 interacts with the Sra-1/WAVE1 complex and with the light chain of kinesin-1, linking kinesin-1 to the Sra-1/WAVE1 complex for anterograde transport to axonal growth cones. Knockdown of Sra-1 and WAVE1 cancels CRMP-2-induced axon outgrowth and multiple-axon formation in hippocampal neurons; knockdown of CRMP-2 or kinesin-1 delocalizes Sra-1 and WAVE1 from growth cones, establishing a kinesin-1-dependent transport mechanism for the Sra-1/WAVE1 complex in axon formation. | Co-immunoprecipitation, RNAi knockdown in hippocampal neurons, immunofluorescence localization in growth cones | Molecular and cellular biology | High | 16260607 |
| 2006 | The RNA helicases p68/p72 (DDX5/DDX17) are MyoD-associated proteins, and the non-coding RNA SRA co-immunoprecipitates with MyoD. Both p68/p72 and SRA function as coactivators of MyoD in skeletal muscle differentiation; RNAi knockdown of either p68/p72 or SRA prevents activation of muscle gene expression and cell differentiation. Loss of p68/p72 impairs recruitment of TBP, RNA polymerase II, and the SWI/SNF catalytic subunit Brg-1, and hinders chromatin remodeling at muscle gene promoters. | Co-immunoprecipitation with MyoD, RNAi knockdown, chromatin immunoprecipitation, reporter assays, differentiation assays | Developmental cell | High | 17011493 |
| 2006 | SLIRP (SRA stem-loop interacting RNA binding protein) binds a functional substructure of SRA RNA (STR7) via its RNA recognition motif (RRM) and functions as a nuclear receptor corepressor. SLIRP represses nuclear receptor transactivation in a SRA- and RRM-dependent manner, augments tamoxifen's effect, modulates SRC-1 association with SRA, and is recruited to endogenous promoters in a SRA-dependent manner. SHARP also binds STR7, augmenting repression with SLIRP. | RNA pull-down, co-immunoprecipitation, reporter assays, chromatin immunoprecipitation, RRM mutagenesis, immunofluorescence | Molecular cell | High | 16762838 |
| 2006 | Alternative splicing of the first intron of SRA1 generates both coding (SRAP-producing) and non-coding SRA RNA isoforms in breast cancer cell lines. The intron-1 sequence is sufficient to drive differential splicing in both endogenous and minigene contexts. The relative proportion of coding vs. non-coding SRA transcripts varies across breast cancer cell lines, suggesting that alternative splicing is a regulatory mechanism controlling the balance between SRA RNA coactivator and SRAP protein. | 5'-RACE, RT-PCR with isoform-specific primers, minigene splicing assay in breast cancer cell lines | DNA and cell biology | Medium | 16848684 |
| 2007 | SRA1 encodes both a non-coding RNA (SRA) and an endogenous protein (SRAP) through alternative splicing of intron-1; retention of intron-1 disrupts the SRAP open reading frame, generating the non-coding isoform. Both SRA RNA and SRAP have opposing regulatory roles on steroid receptor signaling and are conserved among Chordata, establishing SRA1 as a bifaceted gene. | Review/synthesis of published molecular characterization; original data on isoform identification referenced | Nuclear receptor signaling | Low | 17710122 |
| 2008 | SRA1 gene knockout (SRA-/-) in zebrafish using morpholino antisense reagents results in a phenotype of myocardial contractile dysfunction, demonstrating that SRA1 (along with HBEGF and IK, which cosegregate in a 600-kb linkage disequilibrium block) independently contributes to cardiac muscle function in vivo. | Morpholino antisense knockdown in zebrafish, cardiac function assessment | Genome research | Medium | 19064678 |
| 2009 | SRA functions as an RNA coactivator for steroidogenic factor 1 (SF-1), and both SF-1 and Dax-1 bind SRA. Dax-1 acts as a dosage-dependent SF-1 coactivator through SRA; SRA knockdown abolishes Dax-1-mediated coactivation and reduces expression of steroidogenic gene products (StAR, MC2R) in adrenal Y1 cells. TIF2 associates with Dax-1 and synergistically coactivates SF-1 target gene transcription in a SRA-dependent manner. | Co-immunoprecipitation, siRNA knockdown of SRA, reporter assays, qRT-PCR of steroidogenic gene products | Molecular and cellular biology | High | 19188450 |
| 2010 | SRA non-coding RNA enhances myogenic differentiation and myogenic conversion through co-activation of MyoD activity, while SRAP (the protein encoded by the same locus) counteracts this SRA RNA-dependent co-activation. SRAP's inhibitory effect is mediated through its RRM-like domain interacting with functional sub-structure STR7 of SRA RNA, establishing a regulatory feedback between the two products of the SRA1 locus. | Constructs producing exclusively SRA ncRNA or SRAP protein, myogenic differentiation assays in human satellite cells, co-immunoprecipitation, domain mutagenesis | Nucleic acids research | High | 20855289 |
| 2010 | SRA non-coding RNA associates with PPARγ and coactivates PPARγ-dependent gene expression to promote adipogenesis. SRA overexpression in ST2 mesenchymal precursor cells promotes adipocyte differentiation; SRA knockdown inhibits 3T3-L1 preadipocyte differentiation. SRA also increases glucose uptake and Akt/FOXO1 phosphorylation in response to insulin, promotes S-phase entry by decreasing p21Cip1 and p27Kip1 expression, and inhibits TNFα-induced JNK phosphorylation, demonstrating multiple signaling roles. | Co-immunoprecipitation of SRA with PPARγ, reporter assays, siRNA knockdown, overexpression in ST2 cells, flow cytometry, Western blotting for signaling pathway components | PloS one | High | 21152033 |
| 2010 | The DEAD-box RNA helicase p68 (DDX5) and its associated non-coding RNA SRA form a complex with CTCF that is essential for insulator function at the IGF2/H19 imprinted control region (ICR). Depletion of SRA or p68 reduces CTCF-mediated insulator activity, increases IGF2 expression, and reduces cohesin binding to CTCF sites without affecting CTCF binding itself. p68/SRA interacts with cohesin complex members, suggesting that p68/SRA stabilizes cohesin-CTCF interaction. | ChIP, co-immunoprecipitation, siRNA knockdown, chromosome conformation capture (3C), reporter assays for insulator function | Genes & development | High | 20966046 |
| 2010 | Dax1 augments LRH-1-mediated activation of the Oct4 gene in mouse embryonic stem cells through a mechanism dependent on the RNA coactivator SRA; SRA knockdown abolishes Dax1-mediated coactivation of Oct4. Dax1 and LRH-1 co-localize at 43% of LRH-1 target genes involved in mES cell pluripotency, and SRA is required for their co-activation. | Co-immunoprecipitation of Dax1 with LRH-1, ChIP at Oct4 promoter, luciferase reporter assays, siRNA knockdown of SRA, genome-wide ChIP analysis | Molecular endocrinology (Baltimore, Md.) | Medium | 20943815 |
| 2010 | Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signaling during clathrin-AP-1-coated carrier biogenesis at the trans-Golgi network (TGN). CYFIP-containing complexes are recruited to TGN membranes by Arf1 GTPase; Rac1 and its exchange factor β-PIX then activate these complexes to promote N-WASP- and Arp2/3-dependent actin polymerization and tubule formation. These events were reconstituted with synthetic membranes. | Immunoprecipitation of CYFIP complexes, synthetic membrane reconstitution assay, siRNA knockdown, fluorescence microscopy, dominant-negative GTPase experiments | Nature cell biology | High | 20228810 |
| 2010 | SRA RNA depletion in human cancer cell lines (MCF-7 and MDA-MB-231) by siRNA reveals hundreds of endogenous SRA target genes, with the majority reduced upon knockdown, implicating SRA as a broad endogenous coactivator. Novel SRA targets identified include SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2. SRA depletion in MDA-MB-231 cells reduces invasiveness. | siRNA knockdown, microarray gene expression profiling, reporter assays for specific promoters | Molecular endocrinology (Baltimore, Md.) | Medium | 20219889 |
| 2013 | The cytoplasmic RISC proteins PACT, TRBP, and Dicer bind SRA RNA and function as nuclear receptor coregulators. These RISC proteins, together with Argonaute 2, associate with SRA and specific pre-microRNAs in both the nucleus and cytoplasm and target steroid-responsive promoters to regulate nuclear receptor activity and downstream gene expression. | RNA pull-down with SRA, co-immunoprecipitation, ChIP at steroid-responsive promoters, reporter assays, immunofluorescence showing nuclear/cytoplasmic localization | Proceedings of the National Academy of Sciences of the United States of America | Medium | 23550157 |
| 2013 | RNA helicase Ddx5 (p68) is a novel component of the RBP-J/NICD (Notch intracellular domain) complex; Ddx5 directly interacts with RBP-J and localizes to RBP-J binding sites at Notch target gene loci (preTCRα, Hes1, CD25) in a Notch-dependent manner. SRA, as a cofactor of Ddx5, is also required for Notch target gene activation; knockdown of SRA downregulates Hes1 and preTCRα, associated with loss of p300 occupancy and decreased histone acetylation at Notch target genes. | Biotinylation-tagging/mass spectrometry, Co-IP, ChIP, siRNA knockdown, reporter assays | Biochimica et biophysica acta | Medium | 23396200 |
| 2014 | Whole-body Sra1 gene knockout (SRA-/-) mice are resistant to high-fat diet-induced obesity with decreased fat mass, increased insulin sensitivity (reduced fasting insulin, improved glucose tolerance), decreased adipocyte marker gene expression, reduced plasma TNFα, and fewer hepatic lipid droplets with decreased lipogenesis-associated gene expression. This demonstrates an in vivo role for the SRA1 gene product in adipose tissue mass and glucose homeostasis. | Gene knockout mouse model (whole-body Sra1 KO), high-fat diet feeding, body composition analysis, glucose/insulin tolerance tests, gene expression analysis, histology | The Journal of biological chemistry | High | 24675075 |
| 2014 | The crystal structure of the carboxy-terminal domain of human SRAP (SRA protein) reveals a five-helix bundle that is structurally distinct from known RNA-binding motifs and instead resembles the C-terminal domain of the yeast spliceosome protein PRP18. The structure does not contain the postulated RRM (RNA recognition motif), and direct RNA-binding experiments (in vitro with recombinant SRAP and in cell-based assays) failed to reveal a specific interaction between SRAP and SRA RNA, necessitating re-evaluation of the current model for SRAP function. | Crystal structure determination, RNA-binding assays in vitro and in cells, siRNA knockdown with RNA-seq, immunofluorescence for subcellular localization | Journal of molecular biology | High | 24486609 |
| 2015 | SRA lncRNA participates in transcriptional regulation through complex formation with both trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. The SRA-associated RNA helicase p68 preferentially stabilizes SRA-TrxG complex formation over SRA-PRC2. SRA binding sites co-occupied by p68 are enriched for H3K4me3 in NTERA2 pluripotent stem cells. NANOG directly interacts with SRA and co-localizes with it genome-wide. SRA is required for maintaining the stem cell state and for reprogramming human fibroblasts to pluripotency. | Co-immunoprecipitation of SRA with TrxG and PRC2 components, ChIP-seq for histone marks, RNA immunoprecipitation, genome-wide SRA binding analysis, reprogramming assays | PLoS genetics | Medium | 26496121 |
| 2016 | LncRNA SRA promotes hepatic steatosis by repressing expression of adipose triglyceride lipase (ATGL). SRA inhibits ATGL promoter activity primarily by inhibiting the inductive effects of the transcription factor FoxO1. Loss of SRA in primary hepatocytes or hepatocyte cell lines upregulates ATGL expression and free fatty acid β-oxidation, while forced SRA expression inhibits ATGL and β-oxidation. Hepatic SRA and ATGL levels are inversely regulated by fasting in mice. | Sra KO mice, primary hepatocyte isolation, siRNA and overexpression in hepatocyte cell line, ATGL promoter-luciferase reporter assays, FoxO1 co-transfection experiments | Scientific reports | Medium | 27759039 |
| 2016 | In ovarian endometriotic stromal cells (ESCs), SRA1 silencing via siRNA increases ERα expression but reduces ERβ expression, and attenuates proliferation while promoting early apoptosis. LncRNA SRA and ERα are expressed at lower levels, while SRAP and ERβ are higher, in ovarian endometriotic tissues versus normal endometrial tissues, establishing SRA1 products as regulators of estrogen receptor isoform balance in endometriosis. | siRNA knockdown in primary ESCs, RT-PCR and Western blotting for ER isoforms, CCK-8 proliferation assay, flow cytometry for apoptosis, IHC on tissue specimens | Reproductive sciences (Thousand Oaks, Calif.) | Low | 27694140 |
| 2021 | SRSF1 promotes inclusion of exon 3 of SRA1 pre-mRNA to generate the long isoform SRA1-L (which promotes HCC cell invasion) by directly binding to exon 3 of SRA1 pre-mRNA. RNA immunoprecipitation, cross-link immunoprecipitation, RNA pull-down, and minigene-MS2 mutation experiments all confirm SRSF1 binding to the SRA1 exon 3 sequence. SRA1-L overexpression increases CD44 expression and promotes HCC cell migration/invasion in vitro and lung metastasis in vivo; SRA1-S (lacking exon 3) reverses these effects. | RNA immunoprecipitation (RIP), cross-link immunoprecipitation (CLIP), RNA pull-down, minigene-MS2 mutation, siRNA/overexpression, in vivo lung metastasis model | Cell death discovery | High | 34011971 |
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2002 | The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. | Genes & development | 1408 | 12414734 |
| 1994 | Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. | Nature | 1268 | 7990924 |
| 1994 | Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. | Cell | 1239 | 8001137 |
| 2009 | A census of human transcription factors: function, expression and evolution. | Nature reviews. Genetics | 1191 | 19274049 |
| 2007 | The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. | Nature | 985 | 17994007 |
| 2012 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. | Nature genetics | 958 | 22504420 |
| 2017 | Impact of cytosine methylation on DNA binding specificities of human transcription factors. | Science (New York, N.Y.) | 934 | 28473536 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 2012 | Slug and Sox9 cooperatively determine the mammary stem cell state. | Cell | 815 | 22385965 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 1999 | A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. | Cell | 640 | 10199399 |
| 2004 | Interactions between Sox9 and beta-catenin control chondrocyte differentiation. | Genes & development | 637 | 15132997 |
| 1998 | Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene. | Molecular and cellular biology | 482 | 9774680 |
| 2011 | Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. | Nature genetics | 456 | 22001757 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2004 | SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. | The Journal of cell biology | 406 | 15240568 |
| 2008 | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. | Nature | 395 | 18772891 |
| 2008 | Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. | Nature | 379 | 18772889 |
| 2008 | The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. | Nature | 342 | 18772888 |
| 2004 | Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. | The EMBO journal | 325 | 14765121 |
| 2009 | Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence. | Nature genetics | 320 | 19234473 |
| 2007 | The SRA methyl-cytosine-binding domain links DNA and histone methylation. | Current biology : CB | 315 | 17239600 |
| 2003 | Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. | Current biology : CB | 294 | 14588242 |
| 2004 | Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. | The Journal of biological chemistry | 278 | 15623506 |
| 2001 | Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. | Genes & development | 277 | 11331609 |
| 2017 | SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 274 | 28336567 |
| 2016 | SOX9 and the many facets of its regulation in the chondrocyte lineage. | Connective tissue research | 264 | 27128146 |
| 2004 | ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. | Oncogene | 263 | 15361834 |
| 2014 | SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. | Nature | 259 | 24463519 |
| 2006 | The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. | Developmental cell | 248 | 17011493 |
| 2000 | Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. | Molecular and cellular biology | 233 | 10805756 |
| 2013 | ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. | The Journal of clinical investigation | 229 | 23426182 |
| 2001 | A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. | The EMBO journal | 229 | 11250900 |
| 2014 | Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. | Cancer research | 227 | 24906622 |
| 1998 | Toward understanding SOX9 function in chondrocyte differentiation. | Matrix biology : journal of the International Society for Matrix Biology | 212 | 9569122 |
| 2008 | Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. | Arteriosclerosis, thrombosis, and vascular biology | 211 | 18948635 |
| 2011 | Toward an understanding of the protein interaction network of the human liver. | Molecular systems biology | 207 | 21988832 |
| 2005 | CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. | Molecular and cellular biology | 207 | 16260607 |
| 2010 | Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. | Genes & development | 194 | 20966046 |
| 2013 | A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. | PLoS genetics | 190 | 23408906 |
| 2012 | Oncogenicity of the developmental transcription factor Sox9. | Cancer research | 188 | 22246670 |
| 1996 | Sex reversal by loss of the C-terminal transactivation domain of human SOX9. | Nature genetics | 181 | 8640233 |
| 2003 | Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. | The Journal of biological chemistry | 180 | 12732631 |
| 2010 | Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. | PloS one | 176 | 21152033 |
| 2005 | Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. | The EMBO journal | 174 | 15889150 |
| 2001 | Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene. | Lancet (London, England) | 161 | 11755607 |
| 1993 | Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. | Nature genetics | 158 | 8348155 |
| 2011 | Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. | PloS one | 145 | 21731699 |
| 2008 | Three SRA-domain methylcytosine-binding proteins cooperate to maintain global CpG methylation and epigenetic silencing in Arabidopsis. | PLoS genetics | 134 | 18704160 |
| 2008 | SRA-domain proteins required for DRM2-mediated de novo DNA methylation. | PLoS genetics | 128 | 19043555 |
| 1984 | Mutagenesis of the region between env and src of the SR-A strain of Rous sarcoma virus for the purpose of constructing helper-independent vectors. | Virology | 126 | 6330999 |
| 2010 | Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation. | Nucleic acids research | 117 | 20855289 |
| 1999 | Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. | Arteriosclerosis, thrombosis, and vascular biology | 117 | 10073945 |
| 2020 | Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice. | Theranostics | 112 | 31938053 |
| 2013 | Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36. | Atherosclerosis | 112 | 23706521 |
| 2012 | The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression. | Oncogene | 112 | 22330138 |
| 2006 | SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. | Molecular cell | 109 | 16762838 |
| 2012 | Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. | PloS one | 106 | 22470565 |
| 2010 | Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors. | Cardiovascular research | 102 | 20634212 |
| 2014 | SRA gene knockout protects against diet-induced obesity and improves glucose tolerance. | The Journal of biological chemistry | 101 | 24675075 |
| 2016 | The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region. | Cell reports | 100 | 27210747 |
| 2007 | Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer. | Nuclear receptor signaling | 100 | 17710122 |
| 2016 | LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL). | Scientific reports | 96 | 27759039 |
| 2004 | Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development. | Development (Cambridge, England) | 96 | 15294869 |
| 2011 | A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. | Genes & development | 93 | 21245167 |
| 2009 | Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis. | Molecular and cellular biology | 91 | 19188450 |
| 2014 | Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. | Molecular cell | 90 | 24813944 |
| 1994 | The serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a variant surface glycoprotein-like protein. | Molecular and biochemical parasitology | 90 | 7739673 |
| 2013 | RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. | Proceedings of the National Academy of Sciences of the United States of America | 87 | 23550157 |
| 2006 | Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines. | DNA and cell biology | 87 | 16848684 |
| 2010 | Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. | Nature cell biology | 86 | 20228810 |
| 1998 | A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake. | Journal of lipid research | 80 | 9548586 |
| 2008 | Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. | The Journal of biological chemistry | 79 | 18945682 |
| 2008 | HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. | Genome research | 79 | 19064678 |
| 2010 | Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE antibodies. | Allergy | 78 | 20973803 |
| 2009 | Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides. | Nucleic acids research | 77 | 19483093 |
| 2009 | Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation. | Blood | 69 | 19349620 |
| 2010 | EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1. | Cardiovascular research | 66 | 20615914 |
| 2018 | Expression Analysis of MALAT1, GAS5, SRA, and NEAT1 lncRNAs in Breast Cancer Tissues from Young Women and Women over 45 Years of Age. | Molecular therapy. Nucleic acids | 65 | 30126830 |
| 2012 | PKCδ signalling regulates SR-A and CD36 expression and foam cell formation. | Cardiovascular research | 63 | 22687273 |
| 2005 | Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. | The Journal of biological chemistry | 63 | 16040605 |
| 2001 | Escherichia coli ribosome-associated protein SRA, whose copy number increases during stationary phase. | Journal of bacteriology | 63 | 11292794 |
| 2005 | Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), compared with oxybutynin in the treatment of patients with overactive bladder. | World journal of urology | 62 | 16096831 |
| 2005 | Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. | Journal of immunology (Baltimore, Md. : 1950) | 62 | 16339556 |
| 2020 | Xenbase: deep integration of GEO & SRA RNA-seq and ChIP-seq data in a model organism database. | Nucleic acids research | 59 | 31733057 |
| 2006 | The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. | Current biology : CB | 59 | 16860743 |
| 2010 | Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene. | Molecular endocrinology (Baltimore, Md.) | 57 | 20219889 |
| 2019 | Structure Relaxation Approximation (SRA) for Elucidation of Protein Structures from Ion Mobility Measurements. | The journal of physical chemistry. B | 53 | 30866623 |
| 2003 | Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. | The Journal of steroid biochemistry and molecular biology | 53 | 12943696 |
| 2013 | RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway. | Biochimica et biophysica acta | 52 | 23396200 |
| 2002 | Synergically increased expression of CD36, CLA-1 and CD68, but not of SR-A and LOX-1, with the progression to foam cells from macrophages. | Journal of atherosclerosis and thrombosis | 52 | 12238639 |
| 1994 | A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa. | The Journal of biological chemistry | 52 | 8132570 |
| 2018 | Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice. | Medical science monitor : international medical journal of experimental and clinical research | 48 | 29674607 |
| 1992 | Only the serum-resistant bloodstream forms of Trypanosoma brucei rhodesiense express the serum resistance associated (SRA) protein. | Annales de la Societe belge de medecine tropicale | 48 | 1417165 |
| 2022 | Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis. | Drug delivery | 47 | 35119317 |
| 2004 | Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. | Development (Cambridge, England) | 47 | 15269173 |
| 2003 | Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A. | Biochemical and biophysical research communications | 46 | 14521944 |
| 2001 | Cell surface regulation of silica-induced apoptosis by the SR-A scavenger receptor in a murine lung macrophage cell line (MH-S). | Toxicology and applied pharmacology | 45 | 11437644 |
| 2018 | New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action. | Frontiers in medicine | 44 | 30238005 |
| 2011 | Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 44 | 21900555 |
| 2010 | Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. | Molecular endocrinology (Baltimore, Md.) | 44 | 20943815 |
| 2011 | Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity. | Cancer research | 43 | 21914786 |
| 2010 | Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. | Developmental biology | 43 | 20561515 |
| 2016 | Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. | European journal of medicinal chemistry | 42 | 27049577 |
| 2013 | SR-A and SREC-I are Kupffer and endothelial cell receptors for helper-dependent adenoviral vectors. | Molecular therapy : the journal of the American Society of Gene Therapy | 39 | 23358188 |
| 2015 | Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes. | PLoS genetics | 36 | 26496121 |
| 2007 | The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions. | Cell cycle (Georgetown, Tex.) | 36 | 17495528 |
| 2009 | SRA and its binding partners: an expanding role for RNA-binding coregulators in nuclear receptor-mediated gene regulation. | Critical reviews in biochemistry and molecular biology | 35 | 19280430 |
| 2008 | SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors. | Journal of innate immunity | 35 | 20375573 |
| 2003 | The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development. | Development (Cambridge, England) | 35 | 12736202 |
| 2005 | Pathological roles of advanced glycation end product receptors SR-A and CD36. | Annals of the New York Academy of Sciences | 34 | 16037291 |
| 2022 | Using GenBank and SRA. | Methods in molecular biology (Clifton, N.J.) | 33 | 35037198 |
| 2016 | Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis. | Reproductive sciences (Thousand Oaks, Calif.) | 33 | 27694140 |
| 2018 | Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development. | Oncotarget | 32 | 29899856 |
| 2010 | The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells. | Journal of hepatology | 32 | 20338659 |
| 2017 | Roles of the Exogenous H2S-Mediated SR-A Signaling Pathway in Renal Ischemia/ Reperfusion Injury in Regulating Endoplasmic Reticulum Stress-Induced Autophagy in a Rat Model. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 30 | 28472786 |
| 2014 | Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection. | PloS one | 29 | 24498223 |
| 2019 | LncRNA-SRA1 Suppresses Osteosarcoma Cell Proliferation While Promoting Cell Apoptosis. | Technology in cancer research & treatment | 28 | 31106680 |
| 2016 | Genetic variants in lncRNA SRA and risk of breast cancer. | Oncotarget | 28 | 26967566 |
| 2011 | Recruitment of Dnmt1 roles of the SRA protein Np95 (Uhrf1) and other factors. | Progress in molecular biology and translational science | 28 | 21507355 |
| 2021 | SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA. | Cell death discovery | 26 | 34011971 |
| 2008 | The RNA coregulator SRA, its binding proteins and nuclear receptor signaling activity. | IUBMB life | 26 | 18380007 |
| 2004 | Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression. | Parasitology | 26 | 15521633 |
| 2012 | SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages. | Biochimica et biophysica acta | 25 | 23123599 |
| 2011 | SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation. | BMC immunology | 25 | 21736734 |
| 2011 | Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell. | Journal of molecular medicine (Berlin, Germany) | 25 | 22083206 |
| 2015 | Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins. | Nucleic acids research | 24 | 25564526 |
| 2014 | Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. | Journal of molecular biology | 23 | 24486609 |
| 2011 | Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. | American journal of physiology. Renal physiology | 23 | 21795641 |