Affinage

SOX11

Transcription factor SOX-11 · UniProt P35716

Length
441 aa
Mass
46.7 kDa
Annotated
2026-06-10
100 papers in source corpus 40 papers cited in narrative 41 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SOX11 is an HMG-box transcription factor that functions as a pioneer factor and master regulator across neural development, tissue morphogenesis, and oncogenesis (PMID:32350470, PMID:23321250). Structurally, its HMG domain engages nucleosomal DNA at superhelical location 2 to locally distort DNA, detach terminal nucleosomal DNA from the histone octamer, and reposition the histone H4 N-terminal tail, thereby increasing chromatin accessibility, while a C-terminal transactivation domain with a stable alpha-helical structure drives target gene expression more efficiently than its SOXC paralogs (PMID:32350470, PMID:18403418). Its activity and nuclear localization are tuned by post-translational modification: phosphorylation at S30 promotes nuclear localization, SUMOylation at K91 restricts nuclear localization and constrains axon-growth programs, and the deubiquitinase USP11 stabilizes SOX11 protein to support cortical neuron production (PMID:29973868, PMID:33441400, PMID:33579706). In neural development SOX11 is required for neuron survival, proliferation of neural progenitors, and axon growth in both embryonic and adult contexts, while its downregulation upon neuronal maturation is required to permit dendritic branching (PMID:21117150, PMID:23483698, PMID:27225767). SOX11 governs morphogenesis of multiple tissues through direct transcriptional targets, including FSCN1 in epidermal wound re-epithelialization, GDF5 in limb, Fgf9 in palate, and a protocadherin B locus control region in kidney; a CAKUT-associated SOX11 variant impairing transactivation links SOX11 to congenital kidney malformation in patients (PMID:31492871, PMID:23356643, PMID:26826126, PMID:29459093). In mantle cell lymphoma SOX11 drives pathogenesis by blocking terminal B-cell differentiation through direct activation of PAX5, promoting angiogenesis via PDGFA, and enhancing BCR signaling, stromal interactions and immune evasion through CXCR4, PTK2/FAK, and CD70; its own expression is set epigenetically by a shift from repressive to activating histone marks and by CCND1-mediated displacement of HDAC1/2 from the SOX11 locus (PMID:23321250, PMID:25092176, PMID:28533307, PMID:34189576, PMID:30530749, PMID:21738649). SOX11 also acts as a core regulatory circuitry factor in adrenergic neuroblastoma, directly regulating SWI/SNF, NuRD, and PRC1 chromatin-machinery components (PMID:36882421).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2006 Medium

    Established that SOX11 is functionally required in neurons, not merely expressed there, by showing its loss kills neurons and stunts neurite growth.

    Evidence RNAi knockdown in Neuro2a and primary DRG neurons with apoptosis and neurite readouts

    PMID:17055661

    Open questions at the time
    • Direct transcriptional targets driving survival vs. growth not separated
    • Cell-autonomy in vivo not addressed
  2. 2008 High

    Defined the structural basis of SOX11's transactivation by mapping the C-terminal TAD and explaining why SOX11 activates more strongly than its SOXC paralogs.

    Evidence Reporter transactivation assays, domain mapping, and TAD structural analysis

    PMID:18403418

    Open questions at the time
    • Coactivators recruited by the TAD not identified
    • Regulation of TAD/DNA-binding interference in cells unresolved
  3. 2010 High

    Distinguished SOX11 from SOX4 functionally within the SOXC group, showing SOX11 drives early progenitor proliferation while SOX4 supports later survival.

    Evidence Conditional and double Sox4/Sox11 knockout mice plus chicken overexpression in sympathetic ganglia

    PMID:20147379

    Open questions at the time
    • Target genes mediating proliferation vs. survival not defined
    • Mechanism of paralog functional divergence unknown
  4. 2011 High

    Separated SOX11's survival and axon-growth functions genetically, proving a cell-death-independent role in axon outgrowth.

    Evidence Sox11 LacZ-knockin knockout mouse with histology and in vitro axon growth, including cell-death blockade

    PMID:21117150

    Open questions at the time
    • Direct axon-growth target genes not identified
    • How axon vs. survival programs are partitioned unclear
  5. 2013 High

    Identified the central oncogenic mechanism in MCL: SOX11 directly activates PAX5 to enforce a B-cell program and block plasmacytic differentiation.

    Evidence ChIP-microarray, expression profiling, siRNA knockdown, and MCL xenografts

    PMID:23321250

    Open questions at the time
    • Full direct target network beyond PAX5 not mapped
    • Cofactors at the PAX5 locus unknown
  6. 2014 High

    Explained how SOX11 reshapes the MCL microenvironment by directly activating PDGFA (angiogenesis) and CXCR4/PTK2-FAK (migration, adhesion, drug resistance).

    Evidence ChIP, functional migration/adhesion/angiogenesis assays, and xenografts with inhibitor treatment

    PMID:25092176 PMID:28533307

    Open questions at the time
    • Relative contribution of each target to tumor growth not quantified
    • Direct vs. paracrine effects partly entangled
  7. 2018 High

    Resolved how SOX11 expression is set in MCL, showing CCND1 displaces HDAC1/2 from the locus to raise histone acetylation while STAT3 represses it.

    Evidence ChIP, Co-IP, RNAi, overexpression, HDAC inhibitor and cytokine assays

    PMID:30530749

    Open questions at the time
    • Transcription factors directing CCND1/HDAC to the locus unknown
    • Interplay with DNA methylation status not fully integrated
  8. 2018 High

    Demonstrated SOX11 is a bona fide MCL driver in vivo, sufficient to hyperactivate BCR signaling and produce MCL-like disease.

    Evidence Eu-SOX11 transgenic mouse, CyTOF signaling analysis, serial bone marrow transplantation

    PMID:29615403

    Open questions at the time
    • Direct targets linking SOX11 to BTK activation not pinpointed
    • Cooperating lesions for full malignancy not defined
  9. 2018 High

    Extended SOX11 from neural roles to organ morphogenesis, linking it to human CAKUT and identifying direct regulation of a protocadherin B locus control region.

    Evidence Sox11 knockout mouse, ChIP, patient variant transactivation analysis

    PMID:29459093

    Open questions at the time
    • Effector genes downstream of protocadherin regulation in kidney unclear
    • Penetrance of human variant not established
  10. 2019 High

    Established a cytoskeletal output for SOX11 by showing it, with SOX4, directly activates FSCN1 to drive cell motility in epidermal wound re-epithelialization.

    Evidence Mouse knockouts, ChIP, expression profiling, wound-healing assays

    PMID:24310815 PMID:31492871

    Open questions at the time
    • Whether the same motility program operates in tumors not directly tested
    • Division of labor between SOX11 and SOX4 unresolved
  11. 2020 High

    Provided the structural mechanism for SOX11 pioneer activity, showing HMG-domain binding to nucleosomal DNA distorts DNA and increases accessibility.

    Evidence Cryo-EM structures of SOX11 HMG domain on nucleosomes

    PMID:32350470

    Open questions at the time
    • How TAD and PTMs feed back on nucleosome engagement not shown
    • Genome-wide pioneer targeting rules not derived from structure
  12. 2021 High

    Defined post-translational control of SOX11 abundance and localization, with USP11 stabilizing the protein and S30 phosphorylation / K91 SUMOylation gating nuclear access and axon-growth programs.

    Evidence Usp11 knockout mouse and Co-IP; mass spectrometry and phospho/SUMO site mutants with localization and optic-nerve regeneration readouts

    PMID:29973868 PMID:33441400 PMID:33579706

    Open questions at the time
    • Kinases and SUMO E3 ligases acting on SOX11 not identified
    • Crosstalk among phosphorylation, SUMOylation and ubiquitination unresolved
  13. 2023 High

    Positioned SOX11 atop chromatin regulation by showing it acts as a core regulatory circuitry factor directly governing SWI/SNF, NuRD and PRC1 components in adrenergic neuroblastoma.

    Evidence ChIP-seq, super-enhancer and dependency analysis in neuroblastoma cell lines

    PMID:36882421

    Open questions at the time
    • Functional consequence of regulating each chromatin complex not dissected
    • Whether this circuitry generalizes beyond neuroblastoma unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SOX11's pioneer activity, transactivation domain, and post-translational modifications are integrated to select context-specific target gene sets across neurons, epithelia, and tumors remains unresolved.
  • No unified model linking PTM state to genomic target choice
  • Coactivator/corepressor complexes recruited by the TAD largely unidentified
  • Determinants of oncogenic vs. tumor-suppressive output across tissues unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 3 GO:0042393 histone binding 1
Localization
GO:0005634 nucleus 2 GO:0000228 nuclear chromosome 1
Pathway
R-HSA-1266738 Developmental Biology 6 R-HSA-1643685 Disease 4 R-HSA-112316 Neuronal System 3 R-HSA-4839726 Chromatin organization 3 R-HSA-74160 Gene expression (Transcription) 3
Partners
CCND1CTNNB1HSP90AA1USP11WT1

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 The C-terminal 33 residues of SOX11 constitute its transactivation domain (TAD). SOX11 activates transcription more efficiently than SOX4 and SOX12, owing to a more stable alpha-helical structure of its TAD. Acidic domains and the TAD itself interfere with DNA binding. Reporter gene transactivation assays, domain mapping, structural analysis of TAD Nucleic acids research High 18403418
2020 Cryo-EM structures show that SOX11 HMG domain binds nucleosomal DNA at superhelical location 2, locally distorting DNA and facilitating detachment of terminal nucleosomal DNA from the histone octamer, thereby increasing DNA accessibility. SOX11 binding also repositions the N-terminal tail of histone H4 including K16. Cryo-electron microscopy structure determination Nature High 32350470
2006 SOX11 is required for neuron survival and neurite outgrowth. siRNA-mediated knockdown in Neuro2a cells increased apoptosis and decreased neurite growth, upregulated pro-apoptotic BNIP3, and decreased anti-apoptotic TANK. In primary DRG neurons, SOX11 knockdown decreased neurite growth/branching and reduced Arpc3 (actin organizing protein) mRNA. RNAi knockdown in Neuro2a cells and primary DRG neurons, gene expression analysis Neuroscience Medium 17055661
2008 In vivo siRNA-mediated knockdown of Sox11 in injured mouse saphenous nerve transiently inhibited peripheral nerve regeneration of both myelinated and unmyelinated axons. Sox11 knockdown reduced ATF3 expression at transcriptional and translational levels in injured neurons. In vivo siRNA injection via Penetratin conjugation, electron microscopy, immunostaining Brain research Medium 19133245
2013 SOX11 promotes tumor growth in MCL xenograft models. By ChIP-microarray combined with gene expression profiling upon SOX11 knockdown, SOX11 directly targets PAX5. SOX11 silencing downregulates PAX5, induces BLIMP1, and promotes plasmacytic differentiation, blocking terminal B-cell differentiation. ChIP-microarray, gene expression profiling, siRNA knockdown, xenograft mouse model Blood High 23321250
2014 SOX11 directly binds regulatory regions of CXCR4 and PTK2 (FAK), upregulating their expression in MCL cells. This activates PI3K/AKT and ERK1/2 FAK-downstream pathways, enhancing cell migration, stromal adhesion, endothelial transmigration, proliferation, and cell adhesion-mediated drug resistance. ChIP, gene expression analysis, siRNA knockdown, functional migration/adhesion assays, xenograft models, FAK/CXCR4 inhibitor treatment Blood High 28533307
2014 SOX11 directly transcriptionally upregulates PDGFA in MCL cells. SOX11-positive MCL tumors had higher microvascular density and angiogenic gene signatures; conditioned media from SOX11+ cells promoted endothelial cell proliferation, migration, and tube formation. PDGFA inhibition impaired SOX11-enhanced angiogenesis. ChIP, gene expression profiling, conditioned media assays, endothelial cell functional assays, xenograft models with imatinib treatment Blood High 25092176
2010 SOX11 directly reduces tumor growth in hematopoietic malignancies. siRNA knockdown and ectopic overexpression alter proliferation. Gene expression analysis identified Rb-E2F cell cycle regulatory pathways as associated with SOX11-induced growth reduction. SOX11 is epigenetically silenced by DNA methylation in B-cell lymphomas. siRNA knockdown, ectopic overexpression, GeneChip expression analysis, promoter methylation analysis Molecular cancer Medium 20624318
2011 SOX11 epigenetic activation in aggressive B-cell lymphomas is mediated by a shift from inactivating histone marks (H3K9me2, H3K27me3) to activating histone marks (H3K9/14Ac, H3K4me3). SOX11 silencing in non-expressing lymphoid cells correlates with H3K27me3. HDAC inhibitor SAHA reversed SOX11 silencing but DNA methyltransferase inhibitor AZA did not. ChIP, bisulfite sequencing, HDAC inhibitor and DNA methyltransferase inhibitor treatment PloS one Medium 21738649
2011 Sox11 knockout mice show severe reduction in sensory neuron survival in trigeminal and dorsal root ganglia, and arrest of axonal outgrowth in vivo and in vitro. This axonal growth defect could not be fully rescued by blocking cell death, indicating a cell-death-independent role in axon growth. Sox11 knockout mouse (knockin of LacZ replacing Sox11 coding region), histological analysis, in vitro axon growth assay Developmental dynamics High 21117150
2010 In sympathetic nervous system development, Sox11 is required early for proliferation of tyrosine hydroxylase-expressing cells, while Sox4 ensures their survival at later stages. In double Sox4/Sox11 knockout mice, sympathetic ganglia remain hypoplastic due to consecutive proliferation and survival defects, leading to dysautonomia. Mouse mutagenesis (conditional knockouts), overexpression in chicken, histological analysis Development (Cambridge, England) High 20147379
2013 Sox11 is required for both embryonic and adult neurogenesis. Sox11 null embryos develop small, disorganized brains with transient NPC proliferation deficits. Conditional Sox11 deletion in adult NPCs blunts proliferation in the SGZ. Functional genomics identified potential downstream target genes. Sox11 conditional knockout mice (Cre-loxP), BrdU labeling, functional genomics/transcriptomics Developmental dynamics High 23483698
2018 Phosphorylation of SOX11 at serine 30 promotes nuclear over cytoplasmic localization. Mass spectrometry identified 10 putative phosphorylated serine residues in SOX11. Western blot of embryonic mouse brain lysates confirmed SOX11 is post-translationally modified by phosphorylation. Mass spectrometry, phospho-mutant analysis, Western blot, subcellular localization assays Frontiers in molecular neuroscience Medium 29973868
2021 USP11 deubiquitinase stabilizes SOX11 protein in the developing cortex. USP11 deficiency impairs layer 6 neuron production and delays neuronal migration. Disease-associated USP11 mutant fails to stabilize SOX11. USP11 ablation reduces SOX11 protein despite induction of Sox11 mRNA, indicating post-translational regulation. Mouse Usp11 knockout, cortical analysis, co-immunoprecipitation, neuronal migration assays Science advances High 33579706
2021 SUMOylation of SOX11 at lysine 91 (K91) regulates its nuclear localization and function. Non-SUMOylatable SOX11-K91A shows increased nuclear localization and enhanced RGC differentiation in vitro, but promotes RGC death and stronger axon regeneration after optic nerve injury in vivo. RNA-seq showed Sox11 and Sox11K91A increase axon growth gene expression but downregulate Spp1 and Opn4. Site-directed mutagenesis (K91A), in vitro RGC differentiation assay, optic nerve crush model in vivo, RNA-seq eNeuro High 33441400
2012 Sox11 modulates BDNF transcription in an exon promoter-specific manner. Sox11 activates BDNF exon I and IV promoters via Sox binding motif 5'-AACAAAG-3'; mutation of these sites reduces activation. Sox11 overexpression in Neuro2a cells elevated exon IV and VII BDNF transcripts. Luciferase reporter assays, Sox binding site mutagenesis, RT-PCR expression analysis Journal of neuroscience research Medium 22331573
2012 SOX11 and WT1 synergistically regulate the Wnt4 promoter in embryonic kidney mesenchyme. Sox11 and WT1 co-immunoprecipitate from embryonic kidney cells. Dominant negative WT1 mutants (P129L, F154S) that cannot interact with Sox11 cannot activate Wnt4. Morpholino knockdown of wt1 or sox11 in Xenopus inhibited Wnt4 expression in the pronephros. Co-immunoprecipitation, luciferase reporter assay, dominant-negative mutants, morpholino knockdown in Xenopus Experimental cell research High 22465478
2013 SOX11 directly binds conserved SOX family binding sites in the 5' UTR of GDF5 and activates GDF5 expression. SOX11 overexpression in chick limb micromass cultures directly activates GDF5, and enhances Gdf5 expression in developing chick limbs. In vitro reporter assay, micromass cultures, RCAS virus-mediated overexpression in chick limb, binding site analysis BMC developmental biology Medium 23356643
2018 SOX11 expression in MCL is regulated by CCND1 and STAT3. CCND1 increases SOX11 transcription by sequestering HDAC1 and HDAC2 from the SOX11 locus, leading to increased H3K9/14 acetylation. STAT3 activation decreases SOX11 expression; JAK1/JAK2 inhibition or STAT3 knockdown increases SOX11 expression. ChIP, Co-IP, RNAi knockdown, ectopic overexpression, HDAC inhibitor treatment, cytokine stimulation assays Blood High 30530749
2018 SOX11 overexpression in B cells drives BCR signaling hyperactivation (pBTK and downstream molecules) and produces an oligoclonal B-cell hyperplasia with MCL-like immunophenotype (CD5+CD19+CD23-). Serial bone marrow transplant from transgenic donors produces lethal disease with decreasing latency. Transgenic mouse model (Eμ-SOX11-EGFP), phosphocytometric mass cytometry (CyTOF), bone marrow transplantation Blood High 29615403
2016 Sox11 suppresses dendritic morphogenesis of excitatory neurons in mouse cerebral cortex. Loss-of-function causes precocious neurite branching and a neuronal migration defect; gain-of-function inhibits dendritic morphogenesis. Arrival at final cortical position induces Sox11 downregulation, which is required to permit dendritic branching. In utero electroporation and postnatal electroporation (loss- and gain-of-function), morphological analysis The Journal of neuroscience Medium 27225767
2019 SOX11 and SOX4 regulate embryonic epidermal state and are required for wound re-epithelialization. They regulate cytoskeletal/ECM genes and directly target FSCN1 (fascin), which mediates cell migration. Sox11/Sox4 deficiency accelerates differentiation and dramatically impairs cell motility. Mouse knockout models, chromatin immunoprecipitation, gene expression profiling, wound healing assays Nature communications High 31492871
2014 Sox11 overexpression in MSCs transcriptionally activates Runx2 and CXCR4 expression (demonstrated by dual-luciferase reporter assay) and activates the BMP/Smad signaling pathway, enhancing trilineage differentiation and migration of MSCs. Lentiviral overexpression, dual-luciferase reporter assay, ectopic bone formation, western blot, open fracture rat model FASEB journal Medium 25466891
2020 Wnt7b induces Sox11 expression in BMSCs via a β-catenin-independent, Ca2+-dependent Nfatc1 signaling pathway. ChIP-qPCR showed Nfatc1 directly binds the Sox11 promoter. Sox11 in turn transcriptionally activates Ccnb1, Sox2 (proliferation) and Runx2, Sp7 (osteogenesis). ChIP-qPCR, RNA-seq, shRNA knockdown, transgenic mice, immunofluorescence, ex vivo transplantation Stem cells (Dayton, Ohio) Medium 32346881
2021 SOX11 directly upregulates CD70 expression in MCL cells. CD70 overexpression in SOX11+ MCL is associated with increased Treg cell infiltration and an immunosuppressive tumor microenvironment. CD40L stimulation induces CD70 in SOX11+ but not SOX11- MCL cells in vitro. ChIP (binding to CD70 regulatory regions), gene expression analysis, immunohistochemistry, in vitro stimulation assays Blood Medium 34189576
2009 Sox11 overexpression in glioma-initiating cells (NSC-derived) prevents tumorigenesis by inducing neuronal differentiation, accompanied by decreased plagl1 expression. Plagl1 overexpression abolishes neuronal commitment and induces tumorigenicity. Sox11 loss is found in human glioma-initiating cells, and Sox11 overexpression prevents their tumorigenesis in vivo. Gene expression profiling, overexpression assays, in vivo tumorigenesis, limiting dilution assays Cancer research Medium 19808959
2017 Endogenous SOX11 directly binds the SDCCAG8 gene promoter in highly invasive HNSCC cells. Wild-type SOX11 but not a DNA-binding mutant activates SDCCAG8 promoter activity. Inhibitory effects of SOX11 knockdown on proliferation, migration, and invasion were partially rescued by SDCCAG8 overexpression. ChIP, luciferase reporter assay, mutagenesis, quantitative proteomics, rescue assay Journal of experimental & clinical cancer research Medium 30922366
2017 SOX11 binds the slug (SNAI2) promoter and activates its transcription in MCF-7 tamoxifen-resistant breast cancer cells, promoting epithelial-to-mesenchymal transition and suppressing ESR1 expression. Chromatin immunoprecipitation, luciferase reporter assay, gene expression analysis Journal of cellular physiology Medium 32043610
2023 SOX11 is a core regulatory circuitry (CRC) transcription factor in adrenergic neuroblastoma. SOX11 directly regulates 10 SWI/SNF core components (including SMARCC1, SMARCA4/BRG1, ARID1A), HDAC2, PRC1 component CBX2, KDM1A/LSD1, and c-MYB. SOX11 is regulated by multiple adrenergic-specific super-enhancers. ChIP-seq, enhancer analysis, gene expression dependency analysis, neuroblastoma cell line functional studies Nature communications High 36882421
2017 SOX11 binds to HSP90α (HSP90AA1) in head and neck cancer cells. The interaction was identified by Co-IP/LC-MS/MS and validated by Co-IP with western blotting. Co-immunoprecipitation, liquid chromatography-tandem mass spectrometry (LC-MS/MS), western blotting Journal of proteome research Medium 28915052
2018 SOX11 overexpression in HCC cells enhances nemo-like kinase expression and TCF4 phosphorylation, thereby inhibiting Wnt/β-catenin signaling and promoting growth inhibition and apoptosis. Overexpression assays, western blot, cell viability and apoptosis assays Biotechnology and applied biochemistry Low 30517979
2013 Cell-type-specific deletion shows Sox11 is required for proper outflow tract development in both mesodermal cells and neural crest cells. Sox4 and Sox11 become essential after neural crest arrival in the outflow tract for differentiation and interaction through regulation of cytoskeletal, cell adhesion, and ECM molecules. Cell-type-specific conditional deletion in mouse (mesoderm and neural crest), phenotypic analysis Cellular and molecular life sciences High 24310815
2018 Sox11 disruption in mice causes CAKUT including duplex kidney formation. SOX11 directly binds and regulates a locus control region of the protocadherin B cluster. SOX11 regulates elongation of Henle's loop. A CAKUT-associated SOX11 variant identified in patients interferes with SOX11 transactivation capacity. Sox11 knockout mouse, ChIP demonstrating direct binding to protocadherin B locus control region, transactivation assays Kidney international High 29459093
2016 Sox11 deficiency causes cleft palate through mandibular hypoplasia; Sox11 loss reduces cell proliferation in mandibular mesenchyme via Cyclin D1. In vitro assays show Sox11 directly regulates Fgf9 expression, and FGF9 protein application to Sox11-deficient palatal shelves restores BrdU incorporation. Sox11 knockout mouse, BrdU proliferation assay, gene expression analysis, in vitro FGF9 rescue assay The Journal of biological chemistry Medium 26826126
2019 SOX11 promotes cell migration in wounded skin by activating expression of FSCN1 (fascin actin-bundling protein 1) as a direct transcriptional target. Sox11/Sox4 deficiency impairs cell motility and re-epithelialization. ChIP, mouse knockout models, wound healing assays, gene expression profiling Nature communications High 31492871
2017 LHX2 binds distal regulatory elements of Sox11 in cortical progenitors and interacts with NuRD complex subunits LSD1, HDAC2, and RBBP4 to maintain repressive chromatin at the Sox11 locus. Loss of LHX2 increases active histone marks at Sox11 loci and increases Sox11 expression, while LHX2 overexpression decreases it. ChIP, Co-IP (LHX2 with NuRD complex components), conditional knockout, overexpression, histone mark analysis The Journal of neuroscience Medium 28053041
2022 LINC01296 binds nucleolin (NCL) and forms a complex that activates SOX11 gene transcription, promoting neuroblastoma tumorigenesis. Silencing LINC01296 reduces SOX11 expression; RNA pull-down validated the LINC01296-NCL interaction. RNA pull-down assay, Co-IP, luciferase reporter assay, siRNA knockdown, in vivo xenograft Molecular therapy oncolytics Medium 35317520
2019 Sox11 in spinal cord injury promotes neuronal differentiation of endogenous neural stem cells and induces BDNF expression in the injured cord, improving locomotor recovery. Lentiviral Sox11 delivery to injured mouse spinal cord, immunostaining, behavioral assays Biochemical and biophysical research communications Low 24589730
2020 SOX11 confers a hybrid epithelial/mesenchymal (E/M) state in ER-negative breast cancer cells, leading to alterations in metastatic tropism (increased brain and bone metastasis, decreased lung metastasis) in xenograft models. SOX11 overexpression in DCIS.com cells, xenograft mouse model, single-cell analysis, E/M marker analysis eLife Medium 32909943
2015 SOX11 promoter in non-malignant cells shows low methylation with strong H3K27me3 enrichment. In cancer cells with low SOX11 methylation, HDAC inhibitors (vorinostat, trichostatin A) can reactivate SOX11 expression, while cells with dense methylation are resistant to re-expression. Bisulfite sequencing, ChIP-qPCR for H3K27me3, HDAC inhibitor treatment, methylation assays in 42 cell lines BMC cancer Medium 25880212
2019 SOX11 transcriptionally activates β-catenin expression in MSCs (core promoter region -242 to -1414 identified). Sox11 also interacts with β-catenin protein (co-immunoprecipitation) suggesting post-transcriptional regulation in addition to transcriptional activation. Dual-luciferase reporter assay, co-immunoprecipitation, quantitative RT-PCR, in vivo cartilage defect model Cell and tissue research Medium 30617615

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica 277 19880778
2008 The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic acids research 214 18403418
2020 Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 206 32350470
2008 Sox11 transcription factor modulates peripheral nerve regeneration in adult mice. Brain research 121 19133245
2013 SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma. Blood 119 23321250
1997 Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction. Developmental dynamics : an official publication of the American Association of Anatomists 118 9337129
2009 Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. Haematologica 117 19880779
2006 SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Neuroscience 115 17055661
2010 Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development (Cambridge, England) 104 20147379
2002 Differential expression of SOX4 and SOX11 in medulloblastoma. Journal of neuro-oncology 100 12125983
2017 SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma. Blood 99 28533307
2009 Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer research 99 19808959
2014 SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma. Blood 96 25092176
2009 Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. The European journal of neuroscience 96 19490090
2013 Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Developmental dynamics : an official publication of the American Association of Anatomists 92 23483698
2020 Regulatory roles for SOX11 in development, stem cells and cancer. Seminars in cancer biology 78 32574812
1995 The human SOX11 gene: cloning, chromosomal assignment and tissue expression. Genomics 76 8666406
2019 SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. Nature communications 74 31492871
2019 SOX11: friend or foe in tumor prevention and carcinogenesis? Therapeutic advances in medical oncology 70 31210798
2017 RETRACTED: MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression. International journal of molecular sciences 63 28587313
2017 LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. The Journal of neuroscience : the official journal of the Society for Neuroscience 62 28053041
2014 Sox11-modified mesenchymal stem cells (MSCs) accelerate bone fracture healing: Sox11 regulates differentiation and migration of MSCs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 62 25466891
2010 SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies. Molecular cancer 61 20624318
2016 Sox11 Balances Dendritic Morphogenesis with Neuronal Migration in the Developing Cerebral Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 53 27225767
2012 Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. The American journal of surgical pathology 53 22251940
2021 SOX11, CD70, and Treg cells configure the tumor-immune microenvironment of aggressive mantle cell lymphoma. Blood 49 34189576
2015 SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiology of disease 47 25766675
2011 Sox11 regulates survival and axonal growth of embryonic sensory neurons. Developmental dynamics : an official publication of the American Association of Anatomists 47 21117150
2018 SOX11, a key oncogenic factor in mantle cell lymphoma. Current opinion in hematology 46 29738333
2012 SOX11 is useful in differentiating cyclin D1-positive diffuse large B-cell lymphoma from mantle cell lymphoma. Histopathology 45 22642745
2018 SOX11 augments BCR signaling to drive MCL-like tumor development. Blood 43 29615403
2013 Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Cellular and molecular life sciences : CMLS 42 24310815
2020 Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells. Stem cells (Dayton, Ohio) 41 32346881
2017 Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas. American journal of clinical pathology 39 29272888
2013 SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC developmental biology 39 23356643
2011 Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications. PloS one 38 21738649
2017 miR-145 targets the SOX11 3'UTR to suppress endometrial cancer growth. American journal of cancer research 37 29218252
2015 Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 37 26360498
2017 SOX11 promotes invasive growth and ductal carcinoma in situ progression. The Journal of pathology 36 28707729
2021 Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization. Science advances 35 33579706
2013 sox4 and sox11 function during Xenopus laevis eye development. PloS one 35 23874955
2020 SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells. eLife 34 32909943
2023 SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry. Nature communications 33 36882421
2019 Sox11 promotes head and neck cancer progression via the regulation of SDCCAG8. Journal of experimental & clinical cancer research : CR 31 30922366
2018 Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma. Blood 31 30530749
2022 SOX11 variants cause a neurodevelopmental disorder with infrequent ocular malformations and hypogonadotropic hypogonadism and with distinct DNA methylation profile. Genetics in medicine : official journal of the American College of Medical Genetics 28 35341651
2015 The role of tumor suppressor gene SOX11 in prostate cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 28 25773392
2014 Sox11 promotes endogenous neurogenesis and locomotor recovery in mice spinal cord injury. Biochemical and biophysical research communications 28 24589730
2021 Posttranslational Modification of Sox11 Regulates RGC Survival and Axon Regeneration. eNeuro 27 33441400
2018 Different Effect of Sox11 in Retinal Ganglion Cells Survival and Axon Regeneration. Frontiers in genetics 27 30619460
2012 Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner. Journal of neuroscience research 27 22331573
2018 SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β-catenin signaling pathway. Biotechnology and applied biochemistry 26 30517979
2013 SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression. Scientific reports 26 23466598
2020 Upregulation of SOX11 enhances tamoxifen resistance and promotes epithelial-to-mesenchymal transition via slug in MCF-7 breast cancer cells. Journal of cellular physiology 25 32043610
2019 MicroRNA-204-5p targets SOX11 to regulate the inflammatory response in spinal cord injury. European review for medical and pharmacological sciences 25 31173278
2013 Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity. Cancer medicine 25 24402778
2012 WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis. Experimental cell research 25 22465478
2010 SOX11 expression in mantle cell lymphoma. Leukemia & lymphoma 25 20919851
2017 miR-223 is repressed and correlates with inferior clinical features in mantle cell lymphoma through targeting SOX11. Experimental hematology 24 29158064
2017 Role of SOX11 and Genetic Events Cooperating with Cyclin D1 in Mantle Cell Lymphoma. Current oncology reports 23 28466437
2018 Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney international 22 29459093
2012 Expanded clinical and experimental use of SOX11 - using a monoclonal antibody. BMC cancer 22 22738398
2020 LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR-223-3p and targeting SOX11. Cancer medicine 21 32045135
2018 Aberrant methylation of FAT4 and SOX11 in peripheral blood leukocytes and their association with gastric cancer risk. Journal of Cancer 21 30026822
2017 Differential Expression of Sox11 and Bdnf mRNA Isoforms in the Injured and Regenerating Nervous Systems. Frontiers in molecular neuroscience 21 29209164
2016 Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. The Journal of biological chemistry 21 26826126
2013 Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. FEBS letters 21 23313252
2018 Phosphorylation Modulates the Subcellular Localization of SOX11. Frontiers in molecular neuroscience 20 29973868
2017 Observation of Cleft Palate in an Individual with SOX11 Mutation: Indication of a Role for SOX11 in Human Palatogenesis. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 20 29437512
2016 SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Biomarker research 20 26949534
2013 Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival. British journal of cancer 20 23619925
2013 The role of SOX11 in mantle cell lymphoma. Leukemia research 20 24001358
2022 miR-145-5p Inhibits Neuroendocrine Differentiation and Tumor Growth by Regulating the SOX11/MYCN Axis in Prostate cancer. Frontiers in genetics 19 35368699
2019 SOX11 hypermethylation as a tumor biomarker in endometrial cancer. Biochimie 19 30935961
2019 A novel human stem cell model for Coffin-Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Human molecular genetics 19 31035284
2017 Mass Spectrometric Analysis of SOX11-Binding Proteins in Head and Neck Cancer Cells Demonstrates the Interaction of SOX11 and HSP90α. Journal of proteome research 19 28915052
2019 Increased tumour angiogenesis in SOX11-positive mantle cell lymphoma. Histopathology 18 31173643
2019 Highly sensitive and specific in situ hybridization assay for quantification of SOX11 mRNA in mantle cell lymphoma reveals association of TP53 mutations with negative and low SOX11 expression. Haematologica 18 31296581
2011 The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases. Medical oncology (Northwood, London, England) 18 21479697
2019 Promoter hypermethylation of SOX11 promotes the progression of cervical cancer in vitro and in vivo. Oncology reports 17 30720133
2018 SOX11: a potentially useful marker in surgical pathology: a systematic analysis of SOX11 expression in epithelial and non-epithelial tumours. Histopathology 17 30221780
2012 A highly sensitive and specific qPCR assay for quantification of the biomarker SOX11 in mantle cell lymphoma. European journal of haematology 17 22827557
2008 Expression of Sox11 and Brn transcription factors during development and following transient forebrain ischemia in the rat. Neuroscience letters 17 18261853
2024 SOX11 expression is restricted to EBV-negative Burkitt lymphoma and is associated with molecular genetic features. Blood 16 38620074
2023 Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine. PeerJ 16 38084140
2019 SOX11 promotes osteoarthritis through induction of TNF-α. Pathology, research and practice 16 31078342
2015 DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. BMC cancer 16 25880212
2014 Utility and diagnostic pitfalls of SOX11 monoclonal antibodies in mantle cell lymphoma and other lymphoproliferative disorders. Applied immunohistochemistry & molecular morphology : AIMM 16 25229384
2022 SOX11-dependent CATSPER1 expression controls colon cancer cell growth through regulation the PI3K/AKT signaling pathway. Genes & genomics 15 35305240
2018 Increased Expression of Transcription Factor SRY-box-Containing Gene 11 (Sox11) Enhances Neurite Growth by Regulating Neurotrophic Factor Responsiveness. Neuroscience 15 29746989
2021 SOX11, SOX10 and MITF Gene Interaction: A Possible Diagnostic Tool in Malignant Melanoma. Life (Basel, Switzerland) 14 33801642
2016 SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma. Leukemia & lymphoma 14 26757780
2022 LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex. Molecular therapy oncolytics 13 35317520
2021 Multi-Omics Analysis of SOX4, SOX11, and SOX12 Expression and the Associated Pathways in Human Cancers. Journal of personalized medicine 13 34442467
2020 LncRNA RNF144A-AS1 Promotes Bladder Cancer Progression via RNF144A-AS1/miR-455-5p/SOX11 Axis. OncoTargets and therapy 13 33177836
2019 Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats. Cell and tissue research 13 30617615
2024 microRNA-125b-5p alleviated CCI-induced neuropathic pain and modulated neuroinflammation via targeting SOX11. Synapse (New York, N.Y.) 12 39135278
2022 Systematic Investigation of the Multifaceted Role of SOX11 in Cancer. Cancers 12 36551589
2021 LINC01605 regulates proliferation, migration and invasion of colorectal cancer cells via targeting miR-3960/SOX11. European review for medical and pharmacological sciences 12 33629302
2014 Study of promoter DNA methylation of Sox11 and its correlation with tissue-specific expression in the laboratory mouse. Gene 11 25234735

Missed literature

Know a paper Affinage missed for SOX11? Flag it for the maintainers and the community.

No submissions yet.