Affinage

SNX10

Sorting nexin-10 · UniProt Q9Y5X0

Length
201 aa
Mass
23.6 kDa
Annotated
2026-06-10
50 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SNX10 is a PtdIns3P-binding sorting nexin built around an extended phox-homology (PXe) domain that anchors it to endosomal membranes and governs multiple vesicular trafficking pathways across diverse cell types (PMID:25212774, PMID:40052924). Through its association with the V-ATPase complex it targets acidification machinery to the centrosome, where it controls ciliary trafficking of Rab8a to enable ciliogenesis (PMID:21844891). In osteoclasts SNX10 is essential for RANKL-induced differentiation, ruffled-border formation, extracellular acidification, and bone resorption (PMID:22174188, PMID:25811986), and it does so in part by physically interacting with the lysosomal Cl-/H+ exchanger CLC-7 to traffic CLC-7/OSTM1-containing lysosomes to the cell periphery (PMID:41408708). SNX10 also imposes a cell-autonomous brake on the fusion of mature osteoclasts: its loss or the R51Q mutation produces giant dysfunctional osteoclasts via persistent peripheral DC-STAMP and elevated surface La protein, with R51Q SNX10 being unstable and exhibiting altered lipid binding and reduced endocytosis (PMID:32278070, PMID:33975343, PMID:39095084). Causative SNX10 mutations — missense, splice-site, and the R51Q knock-in — produce autosomal recessive osteopetrosis with osteoclasts that form sealing zones but cannot resorb bone, and global loss additionally raises stomach pH and impairs calcium absorption to cause rickets (PMID:22499339, PMID:25811986, PMID:28592808, PMID:32278070). Beyond bone, SNX10 organizes endolysosomal degradative routes: it directs cathepsin A (CTSA) maturation to control LAMP-2A stability and chaperone-mediated autophagy flux (PMID:29452206, PMID:35265214), mediates autophagic degradation of SRC (PMID:31208298), recruits the Mon1-Ccz1 complex to drive phagosome maturation and bacterial killing (PMID:28903313), and acts as a negative regulator of piecemeal mitophagy via dynamic endosome-mitochondria contacts that protect mitochondrial proteins from turnover (PMID:40052924). At the intestinal epithelium SNX10 recruits caspase-5 and PIKfyve to early endosomes to enable cytosolic LPS sensing from bacterial outer membrane vesicles, triggering barrier dysfunction (PMID:34747049).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2011 High

    Established SNX10 as a trafficking adaptor for the V-ATPase, linking it to a defined cellular structure (the centrosome) and process (ciliogenesis) rather than leaving it an orphan sorting nexin.

    Evidence Co-IP, centrosomal imaging, and loss-of-function with rescue in cultured cells and zebrafish

    PMID:21844891

    Open questions at the time
    • Did not define the PtdIns3P/membrane basis of V-ATPase targeting
    • Relationship between ciliary and later osteoclast roles not addressed
  2. 2012 Medium

    Connected SNX10 to osteoclast biology and human osteopetrosis, showing it is required for differentiation and resorption and that a patient missense mutation perturbs the endosomal pathway.

    Evidence siRNA knockdown with resorption assays in osteoclasts; patient osteoclast and dextran endocytosis analysis with homozygosity mapping

    PMID:22174188 PMID:22499339

    Open questions at the time
    • Molecular mechanism connecting SNX10 to ruffled border and acidification not yet defined
    • Reported nuclear/ER localization not reconciled with endosomal function
  3. 2014 High

    Solved the human SNX10 crystal structure, defining an extended PXe domain and pinpointing residues (Tyr32, Arg51) required for protein stability and vacuolation activity, providing a structural basis for disease mutations.

    Evidence X-ray crystallography at 2.6 A with structure-guided mutagenesis and vacuolation assays (building on the SNX11 PXe structure)

    PMID:23615901 PMID:25212774

    Open questions at the time
    • Lipid-binding specificity not directly resolved in the structure
    • How the PXe helices engage partner proteins not shown
  4. 2015 High

    Used tissue-specific knockout mice to mechanistically separate SNX10's osteoclast resorption role from a distinct gastric epithelial role, explaining the combined osteopetrosis-plus-rickets phenotype.

    Evidence Global and osteoclast-specific Snx10 knockout mice with endocytosis, acidification, ruffled border, stomach pH assays and calcium rescue

    PMID:25811986

    Open questions at the time
    • Direct trafficking substrate at the ruffled border not identified here
    • Gastric mechanism beyond pH/calcium absorption not detailed
  5. 2017 Medium

    Expanded SNX10 trafficking roles into MMP9 secretion in osteoclasts and Mon1-Ccz1-dependent phagosome maturation in macrophages, broadening its function from bone to innate immunity.

    Evidence Co-IP/co-localization and KD/KO with MMP9 activity and MAPK readouts; Listeria infection of SNX10-deficient macrophages and mice

    PMID:28498635 PMID:28903313

    Open questions at the time
    • Whether MAPK changes are direct or downstream of trafficking defects unresolved
    • Mechanism of Mon1-Ccz1 recruitment by SNX10 not structurally defined
  6. 2017 Medium

    Confirmed via a splice-site mutation that loss of functional SNX10 yields morphologically large, multinucleated osteoclasts that form sealing zones but lack ruffled borders, foreshadowing a fusion-control role.

    Evidence Whole exome and transcript analysis with functional assays of patient-derived osteoclast progenitors

    PMID:28592808

    Open questions at the time
    • Did not establish why mutant osteoclasts become large
    • No in vivo model in this study
  7. 2018 High

    Identified a direct SNX10-CTSA interaction controlling chaperone-mediated autophagy, defining a molecular substrate-maturation mechanism (CTSA maturation tuning LAMP-2A stability) for SNX10.

    Evidence Pull-down interaction, Snx10 KO mice in alcohol liver injury, LAMP-2A siRNA epistasis, CMA activity assays

    PMID:29452206

    Open questions at the time
    • How SNX10 promotes CTSA maturation enzymatically not resolved
    • Generality of the CMA axis beyond liver not addressed here
  8. 2019 Medium

    Extended SNX10's degradative roles to autophagic clearance of SRC and to PIKfyve/FKBP12 partnerships at early endosomes required for osteoclast lysosome biogenesis.

    Evidence KO mice/cells with autophagy flux assays for SRC; co-IP, co-localization, Y2H, and apilimod epistasis for PIKfyve and FKBP12

    PMID:30887568 PMID:31208298 PMID:31692073

    Open questions at the time
    • Functional consequence of the FKBP12 interaction not directly demonstrated
    • Whether SRC degradation and lysosome biogenesis roles share a common trafficking step unknown
  9. 2020 High

    A R51Q knock-in mouse demonstrated in vivo that this disease allele causes osteopetrosis through absent ruffled borders and failed proton secretion, validating the mutation as causative.

    Evidence R51Q knock-in mice with ruffled border histology, proton secretion, and bone density measurements

    PMID:32278070

    Open questions at the time
    • Did not yet link the proton secretion defect to a specific trafficking cargo
    • Cellular instability of R51Q protein not quantified here
  10. 2021 High

    Defined a cell-autonomous fusion-arrest function: R51Q is unstable with altered lipid binding and reduced endocytosis, and wild-type SNX10 actively limits fusion of mature osteoclasts.

    Evidence R51Q homozygous mice with live fusion imaging, endocytosis assays, and lipid-binding assays on mutant protein

    PMID:33975343

    Open questions at the time
    • Membrane effector linking lipid binding to fusion control not yet identified
    • Lipid species bound by wild-type vs R51Q not fully mapped
  11. 2021 High

    Placed SNX10 at the center of cytosolic LPS sensing, showing it recruits caspase-5 and PIKfyve to early endosomes to release LPS from bacterial OMVs and drive intestinal barrier dysfunction.

    Evidence Co-IP, endosomal fractionation, intestinal epithelial KO, caspase-5 activation assays, SNX10 inhibitor, and colitis mouse model

    PMID:34747049

    Open questions at the time
    • How SNX10 selects OMV-containing endosomes not defined
    • Druggability of the SNX10-caspase-5 axis beyond initial inhibitor unexplored
  12. 2022 Medium

    Showed the SNX10-CTSA-LAMP2A axis is inducible by NSAID-driven CHOP-dependent ER stress, providing a regulatory input that suppresses CMA and causes hepatic lipid accumulation.

    Evidence Primary hepatocytes and HepG2 with diclofenac, CMA reporter, protein-level analyses, and in vivo NSAID/AR7 administration

    PMID:35265214

    Open questions at the time
    • Direct CHOP regulation of the SNX10 locus not mapped
    • Reconciliation with opposite-direction CMA effects in other tissues incomplete
  13. 2024 High

    Resolved the molecular basis of osteoclast gigantism, showing SNX10 loss leaves DC-STAMP persistently at the periphery to permit uncontrolled fusion, with quantitative 3D volumetric confirmation.

    Evidence SNX10-KO mice with EGFP labeling, multiphoton/confocal/SHG imaging, 3D volume analysis, and DC-STAMP immunofluorescence

    PMID:39095084

    Open questions at the time
    • Whether SNX10 directly traffics DC-STAMP not shown
    • Link between DC-STAMP and surface La regulation not addressed here
  14. 2024 Medium

    Broadened SNX10's adaptor function to Wnt signaling, showing it stabilizes LRP6 through direct interaction, with a small molecule (gentisic acid) disrupting this to attenuate Wnt/beta-catenin in atherosclerosis.

    Evidence CETSA/DARTS target engagement, SNX10-LRP6 co-IP, and macrophage-specific SNX10 depletion in vivo

    PMID:39603572

    Open questions at the time
    • Membrane/endosomal step coupling SNX10 to LRP6 stability not defined
    • Generality beyond plaque macrophages unknown
  15. 2025 High

    Multiple studies converged on the trafficking effectors and substrates underlying SNX10's roles: CLC-7/OSTM1 lysosome positioning, surface La regulation, DEPDC5 turnover gating mTORC1, viral entry via AP2M1, and negative regulation of piecemeal mitophagy.

    Evidence Co-IP/co-localization/KO for CLC-7-OSTM1; antibody rescue for surface La (preprint); co-IP and CMA/mTORC1/glycolysis assays for DEPDC5; IP-MS and KO/rescue viral entry assays for AP2M1; respiration, citrate synthase, live imaging, and zebrafish KO for mitophagy

    PMID:40052924 PMID:40645503 PMID:41408708 PMID:41487148 PMID:bio_10.1101_2025.09.07.674639

    Open questions at the time
    • Whether one PtdIns3P-anchored mechanism unifies these diverse cargoes is unresolved
    • Surface La result is a single-lab preprint awaiting peer review
    • Direct vs indirect handling of DEPDC5 and AP2M1 not fully distinguished

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how a single PtdIns3P-binding PXe domain protein achieves selectivity among its many cargoes and pathways (V-ATPase, CLC-7, CTSA, DC-STAMP, caspase-5, mitochondrial contacts), and what determines context-specific partner choice.
  • No structural model of SNX10 bound to any partner protein
  • No unifying biochemical principle for cargo selection across tissues
  • Lipid-binding determinants of wild-type SNX10 only partially mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0008289 lipid binding 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005768 endosome 4 GO:0005764 lysosome 3 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9612973 Autophagy 4 R-HSA-168256 Immune System 2
Partners
AP2M1CLC-7CTSADEPDC5FKBP12LRP6OSTM1PIKFYVE

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 SNX10 interacts with the V-ATPase complex and targets it to the centrosome where ciliogenesis is initiated; SNX10 and V-ATPase together regulate ciliary trafficking of Rab8a, a critical regulator of ciliary membrane extension, establishing an SNX10/V-ATPase vesicular trafficking pathway required for ciliogenesis in vitro and in zebrafish in vivo. Loss-of-function assay in cultured cells and zebrafish morpholino knockdown; co-immunoprecipitation; confocal imaging of centrosomal targeting; rescue experiments Cell research High 21844891
2012 SNX10 is required for RANKL-induced osteoclast formation and resorption activity; silencing SNX10 inhibits osteoclast differentiation, bone resorption on hydroxyapatite, and TRAP secretion. SNX10 localizes to the nucleus and endoplasmic reticulum in osteoclasts. siRNA knockdown of SNX10 in RANKL-stimulated osteoclast precursors; confocal immunofluorescence; subcellular fractionation; qPCR; hydroxyapatite resorption assay Journal of cellular biochemistry Medium 22174188
2012 A missense mutation in SNX10 in osteopetrosis patients results in an abnormally abundant mutant protein with altered distribution, fewer and smaller osteoclasts with markedly deranged resorptive capacity, and a perturbed endosomal pathway as evidenced by altered distribution of internalized dextran. Homozygosity mapping; analysis of patient osteoclasts; dextran endocytosis assay; immunostaining for SNX10 distribution Journal of medical genetics Medium 22499339
2013 Crystal structure of SNX11 reveals a novel extended PX (PXe) domain with two additional C-terminal α-helices; these helices are indispensable for SNX11 in vitro function and the same PXe domain architecture is proposed to be present in SNX10, responsible for its vacuolation activity. X-ray crystallography of truncated SNX11; mutagenesis of C-terminal helices; vacuolation functional assay The Journal of biological chemistry Medium 23615901
2014 Crystal structure of human SNX10 at 2.6 Å resolution reveals an extended phox-homology (PXe) domain; Tyr32 and Arg51 are important for protein stability and vacuolation activity; disease-associated mutation Arg16Leu may affect SNX10 function through protein-protein interactions. X-ray crystallography; structure-guided mutagenesis; vacuolation activity assay Proteins High 25212774
2015 Snx10-deficient osteoclasts show severely defective endocytosis, extracellular acidification, ruffled border formation, and bone resorption. Snx10 is also highly expressed in stomach epithelium and its loss leads to high stomach pH and impaired calcium absorption, causing rickets in addition to osteopetrosis. Global and osteoclast-specific Snx10 knockout mice; endocytosis assays; extracellular acidification measurement; histology of ruffled borders; bone resorption assays; stomach pH measurement; calcium supplementation rescue experiment PLoS genetics High 25811986
2017 SNX10 co-localizes with MMP9 and participates in MMP9 trafficking and secretion; SNX10 knockdown reduces MMP9 secretion and activity while increasing intracellular MMP9 protein; SNX10 knockout osteoclasts show downregulated phosphorylation of JNK, p38, and ERK, indicating SNX10 regulates MMP9 secretion via the JNK-p38-ERK signaling pathway. Immunostaining; co-immunoprecipitation; siRNA knockdown; SNX10 overexpression; SNX10 knockout osteoclasts; western blotting for phospho-JNK/p38/ERK; MMP9 activity assay Journal of cellular biochemistry Medium 28498635
2017 SNX10 splice-site mutation (c.212+1G>T) causes aberrant mRNA splicing with frameshift and premature stop, producing dysfunctional osteoclasts with defective ruffled borders that are unable to resorb bone despite forming sealing zones and appearing morphologically large and multinucleated. Whole exome sequencing; Sanger sequencing; SNX10 transcript analysis; functional analysis of patient-derived osteoclast progenitors; bone resorption assay in vitro Scientific reports Medium 28592808
2017 SNX10 promotes phagosome maturation in macrophages by recruiting the Mon1-Ccz1 complex to endosomes and phagosomes; SNX10 deficiency decreases bacterial killing ability of macrophages and increases susceptibility to Listeria monocytogenes infection in vivo. L. monocytogenes infection of macrophages; immunofluorescence co-localization; knockdown/knockout studies; in vivo infection of SNX10-deficient mice Oncotarget Medium 28903313
2018 SNX10 controls chaperone-mediated autophagy (CMA) activity by mediating cathepsin A (CTSA) maturation; SNX10 directly interacts with CTSA (shown by pull-down assay); SNX10 deficiency inhibits CTSA maturation, increases LAMP-2A stability, and upregulates CMA activity, thereby activating Nrf2 and AMPK signaling pathways and protecting against alcohol-induced liver injury. Snx10 knockout mice; ethanol-fed Lieber-DeCarli model; pull-down assay (SNX10-CTSA interaction); western blotting for LAMP-2A; LAMP-2A siRNA interference; CMA activity assays; primary hepatocyte culture Journal of hepatology High 29452206
2019 SNX10 controls SRC protein levels by mediating autophagosome-lysosome fusion and SRC recruitment for autophagic degradation, thereby regulating SRC-STAT3 and SRC-CTNNB1 signaling pathways in colorectal epithelial cells. SNX10 KO mice and cell lines; autophagy flux assays (MAP1LC3, LAMP1, LAMP2); chloroquine treatment; co-localization of SRC with autophagic markers; western blotting for SRC, STAT3, CTNNB1 pathway components Autophagy Medium 31208298
2019 SNX10 and PIKfyve co-localize to early endosomes in osteoclasts and co-immunoprecipitate in vesicle fractions; both are required for lysosome formation in osteoclasts; apilimod-specific inhibition of PIKfyve requires SNX10 expression and does not inhibit lysosome biogenesis in SNX10-deficient osteoclasts. Co-immunoprecipitation from vesicle fractions; confocal co-localization; overexpression studies; apilimod treatment; genetic deletion of PIKfyve; lysosome formation and TRAP secretion assays Journal of cellular biochemistry Medium 31692073
2019 FKBP12 is a binding partner of SNX10 in osteoclasts; identified by yeast two-hybrid screening, validated by co-immunoprecipitation and co-localization; FKBP12, SNX10, and EEA1 are present in the same subcellular fractions (early endosomes) in osteoclasts. Yeast two-hybrid screening; co-immunoprecipitation; confocal co-localization; sucrose gradient subcellular fractionation Journal of cellular biochemistry Medium 30887568
2020 The R51Q SNX10 knock-in mouse model displays massive osteopetrosis due to osteoclast inactivity caused by absence of ruffled borders and inability to secrete protons, confirming that the R51Q mutation is a causative factor in ARO. R51Q SNX10 knock-in mice; histological analysis of ruffled borders; extracellular proton secretion assay; bone density measurement Bone High 32278070
2021 The R51Q SNX10 mutation causes uncontrolled fusion of mature osteoclasts, generating giant dysfunctional osteoclasts; wild-type SNX10 provides a cell-autonomous mechanism that arrests fusion between mature osteoclasts. The R51Q SNX10 protein is unstable and exhibits altered lipid-binding properties, leading to reduced endocytotic activity and altered membrane homeostasis. R51Q SNX10 homozygous mice; time-lapse live imaging of osteoclast fusion; endocytosis assays; lipid-binding assays with R51Q mutant protein; cell size quantification Journal of cell science High 33975343
2021 SNX10 recruits caspase-5 and PIKfyve to early endosomal membranes upon internalization of Gram-negative bacterial outer membrane vesicles (OMVs); this enables LPS release from OMVs into the cytosol, where caspase-5 activated by cytosolic LPS leads to Lyn phosphorylation, nuclear translocation of Snail/Slug, downregulation of E-cadherin, and intestinal barrier dysfunction. Co-immunoprecipitation; endosomal fractionation; SNX10 deletion in intestinal epithelial cells; caspase-5 activation assays; immunofluorescence; DC-SX029 SNX10 inhibitor treatment; colitis mouse model The EMBO journal High 34747049
2022 NSAIDs induce SNX10 upregulation via a CHOP-dependent ER stress response, which promotes CTSA maturation; matured CTSA then degrades LAMP2A, suppressing CMA activity, impairing PLIN2 degradation, and inducing hepatic lipid accumulation and hepatotoxicity. Mouse primary hepatocytes and HepG2 cells; diclofenac treatment; western blotting for LAMP2A/CTSA/SNX10; CMA reporter assay (KFERQ-PAmCherry); SNX10/LAMP2A overexpression; ER stress pathway analysis; in vivo diclofenac and AR7 administration Theranostics Medium 35265214
2024 SNX10 stabilizes LRP6 by direct interaction; gentisic acid binds SNX10 (confirmed by CETSA and DARTS assays), disrupts the SNX10-LRP6 interaction, and leads to LRP6 degradation, attenuating Wnt/β-catenin pathway activation and macrophage apoptosis in atherosclerotic plaques. CETSA assay; DARTS assay; co-immunoprecipitation of SNX10-LRP6; macrophage-specific SNX10 depletion in vivo; western blotting for LRP6 and β-catenin pathway components Pharmacological research Medium 39603572
2024 SNX10 regulates osteoclast fusion and size in vivo; SNX10-deficient mice display massive osteopetrosis with osteoclasts 2–6-fold larger (by volume and nuclear number) than wild-type, due to persistent DC-STAMP protein at the osteoclast periphery enabling uncontrolled fusion of mature osteoclasts. SNX10-knockout mice; EGFP-labeling of osteoclasts; 2-photon, confocal, and second harmonics generation microscopy; 3D volumetric analysis; DC-STAMP immunofluorescence Journal of bone and mineral research High 39095084
2025 SNX10 is a negative regulator of piecemeal mitophagy; in control conditions SNX10 localizes to early endosomes in a PtdIns3P-dependent manner; under hypoxia-mimicking conditions, SNX10-positive late endosomal structures acquire selected mitochondrial proteins (COX-IV, SAMM50) along with SQSTM1/p62 and LC3B. SNX10 depletion enhances COX-IV turnover, reduces mitochondrial respiration and citrate synthase activity; zebrafish lacking Snx10 show reduced Cox-IV levels, elevated ROS, and ROS-mediated neuronal death. SNX10 depletion in mammalian cells; mitochondrial respiration assay; citrate synthase activity assay; confocal imaging of endosome-mitochondria contacts; zebrafish snx10 knockout; ROS measurement; cell death assay in zebrafish brain The Journal of cell biology High 40052924
2025 SNX10 physically interacts with CLC-7 (lysosomal Cl-/H+ exchanger) and is required for trafficking of CLC-7- and OSTM1-containing lysosomes to the cell periphery in osteoclasts; all three proteins (SNX10, CLC-7, OSTM1) co-localize in LAMP1-positive lysosomes; SNX10-KO osteoclasts show few peripheral lysosomes containing CLC-7 and OSTM1. Co-immunoprecipitation of SNX10 and CLC-7; confocal co-localization of SNX10/CLC-7/OSTM1/LAMP1; comparative phenotyping of SNX10-KO, CLC-7-KO, and OSTM1-KO osteoclasts; osteoclast fusion kinetics analysis Journal of bone and mineral research High 41408708
2025 SNX10 promotes HCoV-OC43 viral entry by facilitating phosphorylation of AP2M1 (AP2 complex subunit μ1), thereby enhancing clathrin-mediated viral endocytosis; SNX10 also promotes endosomal acidification to facilitate viral genome release; SNX10 knockout suppresses viral entry and triggers autophagy-mediated antiviral defense. IP-mass spectrometry identification of AP2M1 as SNX10 interactor; viral binding and internalization assays; SNX10 KO in vitro and in vivo; SNX10 reconstitution rescue; autophagy activation assays Virologica Sinica Medium 40645503
2025 SNX10 interacts with DEPDC5 and recruits it to lysosomes for CMA-mediated degradation; SNX10 knockdown accelerates DEPDC5 degradation, activating the mTORC1 pathway and elevating glycolysis in intestinal epithelial cells. α-hederin impairs the SNX10-DEPDC5 interaction, inhibiting this degradation pathway. Co-immunoprecipitation of SNX10-DEPDC5; lysosomal fractionation; CMA activity assays; SNX10 knockdown/rescue; mTORC1 activity (western blot); glycolysis enzyme assays; α-hederin treatment Journal of pharmaceutical analysis Medium 41487148
2025 Loss of SNX10 leads to elevated surface La protein on osteoclasts; inhibitory antibodies against La suppress excessive osteoclast hyperfusion in SNX10-mutant and OSTM1-mutant osteoclasts and restore resorptive function, linking SNX10-dependent membrane trafficking to regulation of surface La levels and osteoclast fusion control. Surface La detection by antibody staining; inhibitory anti-La antibody treatment of mutant osteoclasts; fusion assays; bone resorption assays; murine and human osteopetrosis cell models bioRxivpreprint Medium bio_10.1101_2025.09.07.674639

Source papers

Stage 0 corpus · 50 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 An SNX10 mutation causes malignant osteopetrosis of infancy. Journal of medical genetics 90 22499339
2018 SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. Journal of hepatology 75 29452206
2011 A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell research 66 21844891
2021 SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. The EMBO journal 62 34747049
2019 SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC. Autophagy 61 31208298
2013 SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 50 23280965
2017 SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts. Scientific reports 44 28592808
2012 SNX10 is required for osteoclast formation and resorption activity. Journal of cellular biochemistry 44 22174188
2015 Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS genetics 41 25811986
2022 SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation. Theranostics 31 35265214
2012 Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia. European journal of medical genetics 26 23123320
2013 Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. The Journal of biological chemistry 23 23615901
2017 SNX10 Plays a Critical Role in MMP9 Secretion via JNK-p38-ERK Signaling Pathway. Journal of cellular biochemistry 22 28498635
2017 SNX10 promotes phagosome maturation in macrophages and protects mice against Listeria monocytogenes infection. Oncotarget 22 28903313
2021 Oral Nanoparticles of SNX10-shRNA Plasmids Ameliorate Mouse Colitis. International journal of nanomedicine 20 33488076
2019 Snx10 and PIKfyve are required for lysosome formation in osteoclasts. Journal of cellular biochemistry 19 31692073
2021 An SNX10-dependent mechanism downregulates fusion between mature osteoclasts. Journal of cell science 14 33975343
2014 Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 13 25212774
2020 Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice. Bone 12 32278070
2019 FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts. Journal of cellular biochemistry 11 30887568
2024 Gentisic acid prevents the development of atherosclerotic lesions by inhibiting SNX10-mediated stabilization of LRP6. Pharmacological research 10 39603572
2023 α-hederin regulates glucose metabolism in intestinal epithelial cells by increasing SNX10 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology 10 36724620
2022 Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis. Molecular immunology 10 36459790
2020 WITHDRAWN: SNX10 deficiency restricts foam cell formation and protects against atherosclerosis by suppressing CD36-Lyn axis. The Canadian journal of cardiology 9 32428616
2019 TCIRG1 and SNX10 gene mutations in the patients with autosomal recessive osteopetrosis. Gene 9 30898715
2017 A Novel Mutation in SNX10 Gene Causes Malignant Infantile Osteopetrosis. Avicenna journal of medical biotechnology 9 29090071
2025 SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer. Proceedings of the National Academy of Sciences of the United States of America 8 40228127
2024 Inhibiting SNX10 induces autophagy to suppress invasion and EMT and inhibits the PI3K/AKT pathway in cervical cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 7 39367898
2017 Generation of induced pluripotent stem cells (ARO-iPSC1-11) from a patient with autosomal recessive osteopetrosis harboring the c.212+1G>T mutation in SNX10 gene. Stem cell research 7 29034896
2025 SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics. The Journal of cell biology 6 40052924
2024 SNX10 regulates osteoclastogenic cell fusion and osteoclast size in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 6 39095084
2023 Ropivacaine inhibits the proliferation and metastasis of gastric cancer cells via the SNX10/SRC/STAT3 pathway. Chemical biology & drug design 6 37989501
2022 Overexpression Pattern of miR-301b in Osteosarcoma and Its Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10. Biochemical genetics 5 35732962
2024 SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation. Molecular immunology 4 38271879
2021 SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest. The EMBO journal 4 34796973
2022 Genome sequencing identifies a large non-coding region deletion of SNX10 causing autosomal recessive osteopetrosis. Journal of human genetics 3 36526684
2021 Does Decreased SNX10 Serve as a Novel Risk Factor in Atrial Fibrillation of the Valvular Heart Disease? - A Case-Control Study. Brazilian journal of cardiovascular surgery 3 33594863
2025 SNX10 Is Involved in Ovarian Cancer Cell Metastasis by Repolarizing Tumor-Associated Macrophages Through mTOR1/Lysosomes Pathway. Biomedicines 2 40426851
2025 SNX10 at the crossroad of endocytosis and piecemeal mitophagy. Autophagy 1 40327657
2025 SNX10 in autosomal recessive osteosclerosis, osteosarcoma, rheumatoid arthritis, and osteoporosis: molecular mechanisms and therapeutic implications. Frontiers in cell and developmental biology 1 40556739
2025 SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy. Virologica Sinica 1 40645503
2025 α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation. Journal of pharmaceutical analysis 1 41487148
2024 FFA intervention on LO2 cells mediates SNX-10 synthesis and regulates MMP9 secretion in LX2 cells via TGF-β1. Archives of biochemistry and biophysics 1 39662717
2021 SNX10 gene mutation in infantile malignant osteopetrosis: A case report and literature review. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 1 33678645
2026 Elaidic acid induces hepatic lipid accumulation by inhibiting chaperone-mediated autophagy via the GAS5/miR-27b-3p/SNX10 axis. Chemico-biological interactions 0 42191079
2025 SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway. Oncology reports 0 40341994
2025 Regulation and signaling of SNX10, a tumor suppressor in hepatocellular carcinoma. Biochimie 0 40617343
2025 Unveiling SNX10: a key player in bladder cancer progression. Translational andrology and urology 0 40800094
2025 Computer-Assisted Screening of Active Compounds in Traditional Chinese Medicine Targeting SNX10 as a Promising Treatment for Inflammatory Bowel Diseases. Basic & clinical pharmacology & toxicology 0 40873068
2025 The molecular and functional interplay between the osteopetrosis-associated proteins SNX10, OSTM1, and CLC-7 during mouse osteoclastogenesis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 0 41408708

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