Affinage

SMARCD3

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 · UniProt Q6STE5

Length
483 aa
Mass
55.0 kDa
Annotated
2026-04-28
34 papers in source corpus 21 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SMARCD3 (BAF60c) is a tissue-specific subunit of the SWI/SNF (BAF) chromatin-remodeling complex that functions as a molecular bridge between lineage-specific transcription factors and the Brg1 ATPase, directing chromatin remodeling at target gene loci to control cardiac, skeletal muscle, smooth muscle, and metabolic differentiation programs. It physically interacts with transcription factors including GATA4, TBX5, MyoD, SRF, Mef2c, Six4, nuclear receptors, and Notch intracellular domain, recruiting the BAF complex to their cognate regulatory elements to activate tissue-specific transcription (PMID:15525990, PMID:14701856, PMID:22068056, PMID:23110084, PMID:36066968, PMID:40585527). Its activity is regulated by signal-dependent phosphorylation—p38α-mediated phosphorylation promotes BAF60c incorporation into the Brg1 complex during myogenesis, while PKCζ/λ-mediated S247 phosphorylation triggers nuclear translocation and lipogenic gene activation (PMID:22068056, PMID:23219531). Beyond chromatin remodeling, BAF60c performs a non-canonical role as part of an RNA–protein complex with nucleophosmin (NPM1) that regulates Reg3b mRNA stability, controlling β-cell–macrophage crosstalk in pancreatic islets (PMID:41806831).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2003 High

    Establishing that BAF60c isoforms serve as a physical link between nuclear receptors and the SWI/SNF complex resolved how tissue-specific transcription factors gain access to chromatin remodeling machinery.

    Evidence Yeast two-hybrid, Co-IP, subcellular fractionation, and transcriptional reporter assays in cell lines

    PMID:14701856

    Open questions at the time
    • No in vivo validation of nuclear receptor coactivation
    • Structural basis of BAF60c–nuclear receptor interaction unknown
  2. 2004 High

    Demonstrating that Baf60c is selectively expressed in heart and somites and bridges GATA4/Tbx5 to Brg1 established it as the tissue-restricted subunit specifying cardiac BAF complex identity.

    Evidence RNAi in mouse embryos, Co-IP of Baf60c with GATA4/Tbx5/Brg1, cardiac differentiation assays

    PMID:15525990

    Open questions at the time
    • Mechanism of tissue-restricted expression not determined
    • No conditional knockout at this stage
  3. 2007 High

    Identifying Baf60c as required for Notch-dependent transcription and left-right asymmetry, and as a Brachyury/Ntl partner in zebrafish myogenesis, broadened BAF60c's known transcription factor repertoire beyond cardiac factors to developmental signaling pathways.

    Evidence RNAi in mouse and zebrafish embryos, Co-IP of Baf60c with NICD/RBP-J and Ntl, Notch reporter and myod/myf5 in situ hybridization

    PMID:17210915 PMID:17363140 PMID:18056260

    Open questions at the time
    • Direct chromatin remodeling at Notch target loci not shown
    • Functional redundancy with BAF60a/b not addressed
  4. 2011 High

    Showing that p38α phosphorylation of BAF60c triggers its incorporation into the Brg1 complex on MyoD-bound promoters resolved how signal-dependent post-translational modification gates SWI/SNF recruitment during myogenesis.

    Evidence In vitro kinase assay with p38α, phosphosite mutagenesis, ChIP, Co-IP, siRNA knockdown in myoblasts

    PMID:22068056

    Open questions at the time
    • Identity of the phosphorylated threonine residue confirmed but phosphoproteomics not performed in vivo
    • Downstream chromatin remodeling kinetics not measured
  5. 2012 High

    Discovery that insulin-stimulated PKCζ/λ phosphorylation at S247 causes BAF60c cytoplasm-to-nucleus translocation to form the lipoBAF complex with USF-1 revealed a second, metabolically regulated phospho-switch controlling lipogenic gene activation.

    Evidence In vitro kinase assay, S247 mutagenesis, subcellular fractionation, Co-IP, ChIP, transgenic mouse overexpression

    PMID:23219531

    Open questions at the time
    • Phosphatase responsible for reversing S247 phosphorylation unknown
    • Structural basis of lipoBAF complex assembly not determined
  6. 2012 Medium

    Identifying TGFβ1-SMAD2/3 as direct transcriptional activators of the Baf60c gene, and Baf60c-SRF interaction at CArG boxes as the effector for smooth muscle gene expression, established the upstream induction and downstream mechanism of Baf60c in smooth muscle differentiation.

    Evidence ChIP for SMAD2/3 at Baf60c promoter and Baf60c at SMC promoters, Co-IP with SRF, siRNA and overexpression in progenitor cells

    PMID:23110084

    Open questions at the time
    • Single-lab study without independent replication
    • Contribution of BAF60a/b to SMC gene regulation not excluded
  7. 2013 High

    Gain- and loss-of-function in skeletal muscle showed BAF60c-Six4 drives Deptor expression to activate Akt and glycolytic metabolism, establishing BAF60c as a metabolic fiber-type determinant and linking it to insulin sensitivity.

    Evidence Muscle-specific transgenic and knockout mice, Co-IP (Baf60c-Six4), Deptor siRNA epistasis, metabolic phenotyping

    PMID:23563706

    Open questions at the time
    • Direct chromatin remodeling at Deptor locus not shown at this stage
    • Human relevance not demonstrated
  8. 2013 High

    Demonstrating that Baf60c-GATA4/Tbx5 opens chromatin at the Nkx2.5 enhancer downstream of Cerberus-1/Nodal inhibition provided the first direct evidence of BAF60c-mediated chromatin accessibility changes at a specific cardiac locus.

    Evidence Chromatin accessibility assay at Nkx2.5 enhancer, Co-IP, siRNA and overexpression rescue in ESC cardiomyogenesis

    PMID:24186978

    Open questions at the time
    • Genome-wide accessibility changes not profiled
    • Temporal dynamics of BAF60c recruitment versus chromatin opening not resolved
  9. 2014 Medium

    Connecting TNFα-ERK signaling to Baf60c downregulation and subsequent Deptor/Akt pathway suppression linked meta-inflammation to BAF60c-dependent metabolic dysfunction in obesity.

    Evidence ERK inhibitor rescue in myotubes and obese mice, transgenic Baf60c overexpression rescue

    PMID:24458360

    Open questions at the time
    • Direct ERK-mediated transcriptional repression mechanism at Baf60c locus not defined
    • Single-lab study
  10. 2022 High

    VSMC-specific Baf60c knockout aggravating abdominal aortic aneurysm formation, combined with mechanistic evidence of SRF-P300-SWI/SNF coactivation, NF-κB repression, and KLF5-BCL2 anti-apoptotic signaling, established BAF60c as a multifunctional guardian of the contractile VSMC phenotype.

    Evidence VSMC-specific Cre-lox KO, Co-IP (SRF-P300-SWI/SNF), ChIP for repressive marks at NF-κB targets and KLF5/BCL2 locus, AAA disease models

    PMID:36066968

    Open questions at the time
    • Whether BAF60c directly recruits repressive machinery to NF-κB targets or acts indirectly not fully resolved
    • Human vascular tissue validation not performed
  11. 2023 High

    Identifying BAF60c-Six4-mediated suppression of secreted Dkk3 as a myofiber-to-stem-cell paracrine signal controlling muscle regeneration revealed a non-cell-autonomous role for BAF60c in the muscle stem cell niche.

    Evidence Myofiber-specific KO and transgenic, Co-IP (Baf60c-Six4), ChIP at Dkk3 locus, Dkk3 knockdown rescue in vivo

    PMID:37284884

    Open questions at the time
    • Direct chromatin remodeling at Dkk3 regulatory elements not shown
    • Relevance to human muscle regeneration not tested
  12. 2025 High

    Demonstrating that BAF60c-Mef2c interaction modulates chromatin accessibility at the Musclin promoter and controls muscle-to-adipose thermogenic crosstalk expanded BAF60c's metabolic role to inter-organ endocrine communication.

    Evidence Muscle-specific KO and transgenic, Co-IP (Baf60c-Mef2c), ATAC-seq at Musclin promoter, in vivo thermogenesis assays

    PMID:40585527

    Open questions at the time
    • Musclin receptor signaling in adipose tissue not characterized in this study
    • Whether Mef2c is uniquely required or redundant with other MEF2 family members not tested
  13. 2026 High

    Discovery that BAF60c forms an RNA-protein complex with NPM1 to stabilize Reg3b mRNA in β cells established a non-canonical, chromatin-independent function for BAF60c in post-transcriptional gene regulation and islet inflammation.

    Evidence β cell-specific KO, RNA immunoprecipitation (BAF60c-NPM1-Reg3b mRNA), mRNA stability assays, Co-IP (BAF60c-NPM1)

    PMID:41806831

    Open questions at the time
    • Whether BAF60c binds RNA directly or only through NPM1 not resolved
    • Scope of BAF60c RNA targets beyond Reg3b unknown
    • Structural basis of the BAF60c-NPM1-mRNA complex not determined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of BAF60c-transcription factor selectivity, the genome-wide landscape of BAF60c-dependent chromatin remodeling events across tissues, potential functional redundancy with BAF60a/BAF60b, and the full extent of its non-canonical RNA-regulatory functions.
  • No high-resolution structure of BAF60c in complex with any partner
  • No systematic genome-wide comparison of BAF60c versus BAF60a/b occupancy
  • Full RNA-binding transcriptome not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 9 GO:0060090 molecular adaptor activity 5 GO:0003723 RNA binding 1
Localization
GO:0005634 nucleus 4 GO:0005694 chromosome 2 GO:0005829 cytosol 1
Pathway
R-HSA-74160 Gene expression (Transcription) 8 R-HSA-4839726 Chromatin organization 6 R-HSA-1266738 Developmental Biology 5 R-HSA-1430728 Metabolism 4 R-HSA-162582 Signal Transduction 3 R-HSA-8953854 Metabolism of RNA 1
Partners
BRG1GATA4MEF2CMYOD1NPM1SIX4SRFTBX5
Complex memberships
SWI/SNF (BAF) complexlipoBAF complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Baf60c (SMARCD3) is expressed specifically in heart and somites in the early mouse embryo and mediates physical interactions between cardiac transcription factors (GATA4, Tbx5) and the BAF complex ATPase Brg1, thereby potentiating activation of cardiac target genes; silencing causes defects in anterior/secondary heart field expansion and cardiac/skeletal muscle differentiation. RNA interference in mouse embryos, cell culture overexpression, co-immunoprecipitation with Brg1 and cardiac transcription factors Nature High 15525990
2003 BAF60c1 and BAF60c2 isoforms physically interact with multiple nuclear receptors and transcription factors, are localized primarily in the cell nucleus, and enhance transcriptional activity of PPARγ and RORα1 in a ligand-independent manner by serving as an anchoring point for SWI/SNF complex recruitment. Yeast two-hybrid screen, co-immunoprecipitation, subcellular fractionation/localization, transcriptional reporter assays The Journal of biological chemistry High 14701856
2011 BAF60c pre-assembles with MyoD on regulatory elements of MyoD-target genes in myoblasts prior to transcription; p38α kinase phosphorylates BAF60c on a conserved threonine in response to differentiation signals, promoting incorporation of the MyoD-BAF60c complex into a Brg1-based SWI/SNF complex that remodels chromatin and activates muscle gene transcription. ChIP, co-immunoprecipitation, phosphorylation assays with p38α kinase, siRNA knockdown with transcriptional readouts, mutagenesis of threonine phosphorylation site The EMBO journal High 22068056
2007 Baf60c is required for Notch-dependent transcriptional activation and functions to stabilize interactions between activated Notch (NICD) and its DNA-binding partner RBP-J; Brg1 is also required, indicating BAF complexes are key components of nuclear Notch signaling and are essential for establishing left-right asymmetry via Nodal activation at the node. Baf60c knockdown in mouse embryos (RNAi) and zebrafish, cell culture Notch transcription reporter assays, co-immunoprecipitation of Baf60c with NICD and RBP-J Proceedings of the National Academy of Sciences of the United States of America High 17210915
2012 In response to insulin, BAF60c is phosphorylated at S247 by atypical PKCζ/λ, causing translocation from cytoplasm to nucleus; nuclear BAF60c then directly interacts with phosphorylated/acetylated USF-1 to form the lipoBAF complex, which remodels chromatin and activates lipogenic genes (fatty acid synthase, GPAT), increasing triglyceride levels in vivo. In vitro kinase assay with PKCζ/λ, subcellular fractionation, co-immunoprecipitation (BAF60c-USF-1), ChIP, mutagenesis of S247, transgenic mouse overexpression Molecular cell High 23219531
2013 Baf60c (Smarcd3) in skeletal muscle promotes a switch from oxidative to glycolytic myofiber type by inducing Deptor expression through the Baf60c-Six4 transcriptional complex; Deptor then mediates activation of Akt and glycolytic metabolism in a cell-autonomous manner, protecting mice from diet-induced insulin resistance. Muscle-specific transgenic overexpression, muscle-specific knockout, metabolic phenotyping, co-immunoprecipitation (Baf60c-Six4), siRNA knockdown of Deptor, Akt phosphorylation assays Nature medicine High 23563706
2013 SMARCD3/Baf60c expression in epithelial cells induces EMT by upregulating Wnt5a expression; RNAi knockdown of Wnt5a or use of blocking antibody reversed Smarcd3-induced EMT, placing Wnt5a downstream of SMARCD3 in this pathway. RNAi screen, gain- and loss-of-function in breast cancer cell lines, Wnt5a RNAi and blocking antibody rescue experiments, EpCAM/E-cadherin flow cytometry Molecular and cellular biology Medium 23716599
2013 Nodal inhibition by Cerberus-1 induces Baf60c expression in multipotent cardiac progenitors (KDR/Flk1+); Baf60c interacts with GATA4 and Tbx5 to direct SWI/SNF complex (via Brg1) to cardiomyogenic loci, mediating developmental opening of chromatin at the Nkx2.5 cardiac enhancer; overexpression of Baf60c rescued Cer1 or Brg1 siRNA-induced deficits, placing Baf60c downstream of Cer1. siRNA knockdown, ATAC/chromatin accessibility assay at Nkx2.5 enhancer, overexpression rescue, co-immunoprecipitation (Baf60c-GATA4/Tbx5), embryonic stem cell cardiomyogenesis model Genes & development High 24186978
2007 In zebrafish, Smarcd3 physically interacts with the T-box transcription factor No tail (Ntl/Brachyury), and Smarcd3 overexpression fails to rescue myod expression in ntl mutants; Smarcd3b is the limiting factor that regulates the onset of myogenesis (myod/myf5 expression) downstream of Fgf and Ntl signaling. Co-immunoprecipitation (Smarcd3-Ntl), overexpression in zebrafish embryos, ntl mutant epistasis analysis, in situ hybridization for myod/myf5 The Journal of biological chemistry Medium 18056260
2007 BAF60c1 and BAF60c2 physically interact with retinoic acid receptors (RARs) and act as coactivators; this coactivating activity is dependent on SRC1 (a HAT coactivator), demonstrating cooperation between SWI/SNF and histone acetyltransferase complexes in RAR-mediated transcription. Co-immunoprecipitation, transcriptional reporter assays, SRC1 knockdown epistasis Molecular and cellular endocrinology Medium 17363140
2008 Baf60c is a component of a neural progenitor-specific BAF complex; its overexpression in retinal progenitors keeps them in a proliferative state through interaction with the Notch pathway, and Baf60c expression is lost upon neural differentiation but re-expressed in Müller glia that re-enter the cell cycle. Immunofluorescence and expression analysis in mouse/human retina, overexpression in retinal progenitors with proliferation readout, Notch pathway interaction assays Developmental dynamics Medium 18816825
2012 TGFβ1 activates Baf60c transcription via direct binding of SMAD2/3 complexes to the Baf60c promoter; Baf60c then regulates smooth muscle cell (SMC) gene expression through interaction with SRF at CArG box-containing promoter elements; Baf60c knockdown decreases SMC gene expression while ectopic expression is sufficient to commit progenitor cells to SMC fate in the absence of exogenous cytokines. ChIP (SMAD2/3 at Baf60c promoter, Baf60c at SMC gene promoters), co-immunoprecipitation (Baf60c-SRF), siRNA knockdown, overexpression, in vivo vessel contribution assay PloS one Medium 23110084
2014 Proinflammatory cytokine TNF-α downregulates Baf60c and Deptor in skeletal muscle via ERK activation; ERK inhibition (U0126) rescues Baf60c and Deptor expression and lowers blood glucose in obese mice; transgenic Baf60c rescue in muscle restores Deptor expression and Akt phosphorylation, linking meta-inflammation to the Baf60c/Deptor/Akt pathway. ERK inhibitor treatment of myotubes and obese mice, transgenic overexpression rescue, Akt phosphorylation western blot, blood glucose measurement Diabetes Medium 24458360
2022 In vascular smooth muscle cells, BAF60c preserves contractile phenotype by strengthening SRF association with coactivator P300 and the SWI/SNF complex; suppresses NF-κB target gene inflammation by promoting a repressive chromatin state; and prevents apoptosis through transcriptional activation of KLF5-dependent BCL2 expression. VSMC-specific Baf60c knockout aggravated AAA formation in mice. VSMC-specific Cre-lox knockout, co-immunoprecipitation (SRF-P300-SWI/SNF), ChIP for repressive chromatin marks at NF-κB targets, ChIP for KLF5/BCL2 locus, angiotensin II and elastase AAA models The Journal of clinical investigation High 36066968
2023 SMARCD3 regulates DAB1-mediated Reelin signaling in Purkinje cell migration and medulloblastoma metastasis by orchestrating cis-regulatory elements at the DAB1 locus; increased SMARCD3 activates Reelin-DAB1-Src kinase signaling; EZH2 and NFIX coordinate at the SMARCD3 locus chromatin hub to control SMARCD3 expression. Integrated genomic/epigenomic analysis, ChIP-seq, ATAC-seq, in vivo mouse models, Src kinase inhibitor treatment Nature cell biology Medium 36849558
2023 Myofiber Baf60c interacts with Six4 to synergistically suppress myocyte Dkk3 expression; myofiber-specific ablation of Baf60c upregulates secreted Dkk3, which inhibits muscle stem cell differentiation and attenuates muscle regeneration; Dkk3 blockade or Baf60c transgenic expression promotes muscle regeneration. Myofiber-specific Cre-lox knockout and transgenic overexpression, co-immunoprecipitation (Baf60c-Six4), ChIP at Dkk3 locus, in vivo muscle regeneration assays, Dkk3 knockdown rescue The Journal of experimental medicine High 37284884
2025 Baf60c physically interacts with the transcription factor Mef2c and modulates chromatin accessibility at proximal promoter regions upstream of the Musclin gene TSS, negatively regulating Musclin expression in skeletal muscle; muscle-specific Baf60c ablation elevates Musclin and inhibits adipose tissue thermogenesis, while overexpression increases thermogenesis via Musclin-mediated muscle-fat crosstalk. Muscle-specific Cre-lox knockout and transgenic overexpression, co-immunoprecipitation (Baf60c-Mef2c), ATAC-seq at Musclin promoter, in vivo metabolic assays (thermogenesis, glucose metabolism) Life metabolism High 40585527
2026 BAF60C forms an RNA-protein complex with nucleophosmin (NPM1) and Reg3b mRNA to modulate Reg3b mRNA decay (a non-canonical role distinct from chromatin remodeling); β cell-specific BAF60C deletion aggravates nucleolar stress and islet inflammation by reducing REG3B expression and secretion, impairing β cell-macrophage crosstalk in type 2 diabetes. β cell-specific Cre-lox knockout and overexpression, RNA immunoprecipitation (BAF60C-NPM1-Reg3b mRNA complex), mRNA stability assays, co-immunoprecipitation (BAF60C-NPM1), islet inflammation and glucose homeostasis assays Developmental cell High 41806831
2016 Knockdown of Smarcd3/Bap60 (Drosophila ortholog) in endothelial cells increases NF-κB-dependent inflammatory signaling; in mammalian aortic endothelial cells exposed to oscillatory shear stress, smarcd3 expression is reduced and siRNA knockdown of smarcd3 induces endothelial inflammation, identifying it as a mechanosensitive anti-inflammatory gene. Drosophila RNAi screen (NF-κB reporter readout), siRNA knockdown in mammalian aortic endothelial cells with inflammatory marker readout, oscillatory shear stress in vitro Scientific reports Medium 27819340
2023 In cervical cancer, the lncRNA UCA1 promotes SMARCD3 ubiquitination and proteasomal degradation, reducing SMARCD3 protein stability; UCA1-SMARCD3 protein interaction was identified by RNA pull-down and RIP, and ubiquitination assays confirmed UCA1-promoted SMARCD3 degradation. RNA pull-down, RNA immunoprecipitation, ubiquitination assays, co-immunoprecipitation, gain- and loss-of-function in cell lines and xenografts Molecular carcinogenesis Medium 38116886
2020 BAF60C loss in cardiomyocytes leads to cell cycle defects (increased endoreplication, accumulation of p21 without cell cycle arrest) and unrepaired DNA damage accumulation, identifying SMARCD3 as a regulator of cell cycle checkpoint integrity. siRNA knockdown in ER+ breast cancer cells, flow cytometry (cell cycle analysis), immunofluorescence (p21, DNA damage markers), microscopy Breast cancer research and treatment Medium 33180234

Source papers

Stage 0 corpus · 34 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature 441 15525990
2011 Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex. The EMBO journal 163 22068056
2013 Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. PloS one 125 23704920
2013 Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature medicine 122 23563706
2003 Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. The Journal of biological chemistry 113 14701856
2007 Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proceedings of the National Academy of Sciences of the United States of America 97 17210915
2013 SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling. Molecular and cellular biology 61 23716599
2022 BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. The Journal of clinical investigation 60 36066968
2012 Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin. Molecular cell 58 23219531
2014 The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity. Diabetes 43 24458360
2013 Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment. Genes & development 42 24186978
2007 The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. Molecular and cellular endocrinology 38 17363140
2008 Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Developmental dynamics : an official publication of the American Association of Anatomists 36 18816825
2023 A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis. Nature cell biology 26 36849558
2016 Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism. Nutrition & metabolism 23 27127533
2020 The SWI/SNF subunit SMARCD3 regulates cell cycle progression and predicts survival outcome in ER+ breast cancer. Breast cancer research and treatment 22 33180234
2016 Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice. Development, growth & differentiation 22 27125315
2007 Smarcd3 regulates the timing of zebrafish myogenesis onset. The Journal of biological chemistry 20 18056260
2023 Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling. The Journal of experimental medicine 19 37284884
2013 The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis. Cardiovascular research 18 23787002
2015 Gata4, Tbx5 and Baf60c induce differentiation of adipose tissue-derived mesenchymal stem cells into beating cardiomyocytes. The international journal of biochemistry & cell biology 16 26071180
2012 The BAF60c-MyoD complex poises chromatin for rapid transcription. Bioarchitecture 13 22880151
2018 Intensive Glucose Control Reduces the Risk Effect of TRIB3, SMARCD3, and ATF6 Genetic Variation on Diabetic Vascular Complications. Frontiers in pharmacology 11 30618737
2012 TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence. PloS one 11 23110084
2022 LncRNA SMARCD3-OT1 Promotes Muscle Hypertrophy and Fast-Twitch Fiber Transformation via Enhancing SMARCD3X4 Expression. International journal of molecular sciences 9 35562902
2023 lncRNA UCA1 promotes tumor progression by targeting SMARCD3 in cervical cancer. Molecular carcinogenesis 8 38116886
2020 The mechanism behind BAF60c in myocardial metabolism in rats with heart failure is through the PGC1α-PPARα-mTOR signaling pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire 7 33245682
2024 SMARCD3 Overexpression Promotes Epithelial-Mesenchymal Transition in Gastric Cancer. Cancers 5 38927986
2016 Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Scientific reports 5 27819340
2025 Baf60c in skeletal muscle regulates adipose tissue thermogenesis via Musclin-mediated endocrine signaling. Life metabolism 1 40585527
2023 Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish. iScience 1 37942006
2026 BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes through controlling Reg3b mRNA decay. Developmental cell 0 41806831
2025 SMARCD3 Promotes Epithelial-Mesenchymal Transition in Gastric Cancer by Integrating PI3K-AKT and WNT/β-Catenin Pathways. Cancers 0 41228321
2025 System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells. Cell reports. Medicine 0 41260207