Affinage

SMARCA1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 · UniProt P28370

Round 2 corrected
Length
1042 aa
Mass
121.1 kDa
Annotated
2026-04-28
130 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SMARCA1 (SNF2L) is the catalytic ATPase subunit of multiple ISWI-family chromatin remodeling complexes—including NURF and CERF—that reposition nucleosomes to regulate gene expression during neural development and other processes (PMID:14609955, PMID:15640247, PMID:28801535). Its remodeling activity is gated by two conserved autoinhibitory domains, AutoN and NegC, which restrict ATP hydrolysis and productive DNA translocation, respectively; these are relieved by the histone H4 basic patch and extranucleosomal DNA, ensuring substrate-specific activation (PMID:23143334, PMID:27919072, PMID:30872815). SMARCA1 is recruited to H3K4me3-marked chromatin via the PHD finger of its NURF partner BPTF and can also be guided to specific promoters by lncRNAs such as DLEU1 (PMID:16728976, PMID:30098595). Beyond its chromatin role, the ISWI ortholog functions as a RanGTP-dependent microtubule-associated protein required for spindle integrity and anaphase chromosome segregation (PMID:20008562).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2002 High

    Establishing how the nucleosome substrate regulates ISWI activity: H4K16 acetylation was shown to antagonize ISWI function, revealing that the unmodified H4 tail is a critical activating signal for the ATPase.

    Evidence Drosophila genetic epistasis combined with peptide competition ATPase assays

    PMID:11882543

    Open questions at the time
    • Whether the H4K16ac effect is direct on the mammalian SNF2L enzyme was not tested
    • The structural basis for H4-tail recognition was unknown
  2. 2003 High

    Identifying the biological context of mammalian SMARCA1: purification of human NURF (hNURF) established SNF2L as its ATPase subunit, showed enrichment in brain, and linked the complex to Engrailed-dependent neurite outgrowth.

    Evidence Biochemical purification, reporter assays, and neurite outgrowth in cultured cells

    PMID:14609955

    Open questions at the time
    • In vivo requirement for hNURF in mammalian brain development was not demonstrated
    • How SNF2L is targeted to Engrailed regulatory elements was unclear
  3. 2005 High

    Expanding the repertoire of SMARCA1 complexes: discovery of CERF (CECR2–SNF2L) demonstrated that SMARCA1 functions in a second remodeling complex, and Cecr2 knockout mice linked this complex to neurulation.

    Evidence Co-purification, in vitro remodeling assays, and mouse genetrap knockout causing exencephaly

    PMID:15640247

    Open questions at the time
    • Whether CERF has distinct genomic targets from NURF was unknown
    • The contribution of SNF2L catalytic activity versus CECR2 scaffolding was not dissected
  4. 2006 High

    Determining how SMARCA1 is targeted to active chromatin: the PHD finger of BPTF was shown to read H3K4me3, coupling this epigenetic mark to NURF/SNF2L recruitment at Hox gene promoters.

    Evidence Peptide pulldown, ChIP, and Xenopus loss-of-function

    PMID:16728976

    Open questions at the time
    • Whether H3K4me3-directed recruitment is the sole targeting mechanism for SNF2L was not resolved
    • Mammalian in vivo validation was lacking
  5. 2009 High

    Revealing a non-chromatin function: ISWI/SMARCA1 ortholog was identified as a RanGTP-dependent microtubule-associated protein that nucleates and bundles microtubules, with depletion causing spindle collapse and failed anaphase chromosome segregation.

    Evidence In vitro MT assembly reconstitution, Xenopus egg extract depletion, Drosophila S2 cell RNAi, and live imaging

    PMID:20008562

    Open questions at the time
    • Whether mammalian SMARCA1 retains the mitotic MT function was not shown
    • The relationship between chromatin remodeling and MT-stabilizing activities is unresolved
  6. 2012 High

    Defining the autoinhibitory mechanism: two conserved domains (AutoN and NegC) were shown to suppress ATPase activity and productive DNA translocation, respectively, and are antagonized by the H4 basic patch and extranucleosomal DNA—explaining why ISWI remodels only appropriate nucleosomal substrates.

    Evidence Domain deletion/mutagenesis with in vitro ATPase and nucleosome sliding assays on Drosophila ISWI

    PMID:23143334

    Open questions at the time
    • Structural basis for AutoN and NegC inhibition was not yet available
    • Whether human SNF2L autoinhibition follows identical rules was assumed but not directly tested
  7. 2016 High

    Providing the structural basis for autoinhibition and H4-tail activation: crystal structures revealed that AutoN binds RecA-like core2 to lock ISWI in an inactive state, and the H4 tail competes at an overlapping binding site to relieve inhibition.

    Evidence X-ray crystallography of M. thermophila ISWI with structure-function mutagenesis

    PMID:27919072

    Open questions at the time
    • Full nucleosome-bound structure was not obtained
    • NegC relief mechanism upon extranucleosomal DNA sensing lacked atomic detail
  8. 2017 High

    Refining the N-terminal regulatory region: AutoN was shown not to be a simple pseudosubstrate; instead it cooperates with AcidicN and ppHSA motifs to confer H4-tail sensitivity and discriminate nucleosomes from free DNA, with ppHSA required in vivo.

    Evidence Mutagenesis, in vitro ATPase/sliding assays, cross-linking, Drosophila in vivo complementation

    PMID:28109157

    Open questions at the time
    • How AcidicN and ppHSA are affected by post-translational modifications is unknown
    • Whether regulatory subunits modulate AutoN/NegC gating was not addressed
  9. 2017 Medium

    Expanding ISWI complex combinatorics: endogenous co-purification showed SNF2L can pair with every known ISWI regulatory subunit (including a novel partner BAZ2B), vastly increasing the diversity of SMARCA1-containing complexes.

    Evidence Endogenous co-purification and reconstitution of active complexes with nucleosome remodeling assays

    PMID:28801535

    Open questions at the time
    • Functional specificity of each SNF2L-containing complex was not distinguished
    • In vivo relevance of BAZ2B–SNF2L pairing was not established
  10. 2019 High

    Visualizing the remodeling mechanism at near-atomic resolution: cryo-EM structures of nucleosome-bound ISW1 revealed that substrate binding triggers major rearrangement of catalytic domains with AutoN repacking and NegC disordering, and that DNA is translocated with local distortion but without notable histone deformation.

    Evidence Cryo-EM at 3.3 Å resolution with crosslinking-based functional validation

    PMID:30872815

    Open questions at the time
    • Structures of mammalian SNF2L on nucleosomes are still lacking
    • Transition-state intermediates during the full translocation cycle were not captured

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the genomic target specificity and non-redundancy of each SMARCA1-containing complex in mammalian tissues; whether the mitotic microtubule function of SMARCA1 is conserved and physiologically relevant in mammals; and the mechanistic contribution of SMARCA1 variants to neurodevelopmental and psychiatric disease.
  • No mammalian conditional knockout systematically comparing complex-specific phenotypes
  • Mitotic MT role not tested in mammalian cells
  • Disease-linked SMARCA1 variants lack functional validation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140657 ATP-dependent activity 6 GO:0042393 histone binding 4 GO:0003677 DNA binding 2 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005634 nucleus 3 GO:0005694 chromosome 2 GO:0005856 cytoskeleton 1
Pathway
R-HSA-4839726 Chromatin organization 6 R-HSA-1266738 Developmental Biology 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 1
Partners
BAZ2BBPTFCECR2DLEU1
Complex memberships
CERFNURF

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 The PHD finger of BPTF (the large subunit of the NURF complex) directly binds trimethylated histone H3 lysine 4 (H3K4me3), coupling this epigenetic mark to recruitment of the associated ATPase SNF2L (SMARCA1) to target promoters such as HOXC8. Depletion of H3K4me3 causes partial release of BPTF from chromatin and defective recruitment of SNF2L, and loss of BPTF in Xenopus embryos compromises spatial control of Hox gene expression. Peptide pulldown, ChIP, Xenopus loss-of-function, co-immunoprecipitation Nature High 16728976
2003 Human SNF2L (SMARCA1) was purified as the ATPase catalytic subunit of a human NURF complex (hNURF) orthologous to Drosophila NURF. hNURF is enriched in brain tissue and directly regulates expression of the homeodomain protein Engrailed, potentiating neurite outgrowth in cell culture. Biochemical purification, immunoprecipitation, reporter gene assays, neurite outgrowth assay The EMBO journal High 14609955
2005 SNF2L (SMARCA1) forms a novel heterodimeric chromatin remodeling complex (CERF) with CECR2, a bromodomain- and DDT-domain-containing protein. CERF remodels chromatin in vitro and has nucleosome-stimulated ATPase activity. Loss of Cecr2 in mice causes exencephaly (neural tube defect), implicating SNF2L-containing CERF in neurulation. Biochemical co-purification, in vitro chromatin remodeling assay, ATPase assay, mouse genetrap knockout Human molecular genetics High 15640247
2002 Drosophila ISWI (ortholog of SMARCA1) activity is negatively regulated by acetylation of histone H4 at lysine 16 (H4K16ac). H4K16 acetylation reduces ISWI's ability to interact productively with its nucleosome substrate, as shown by peptide competition assays; blocking H4K16ac suppresses X-chromosome defects from ISWI loss, while forced H4K16ac in ISWI mutant females phenocopies ISWI mutant males. Drosophila genetics (epistasis), peptide competition ATPase assay, MOF overexpression EMBO reports High 11882543
2007 The histone acetyltransferase GCN5 acetylates Drosophila ISWI (ortholog of SMARCA1) at a single conserved lysine (K753) in vivo and in vitro. The target sequence is similar to the N-terminus of histone H3 where GCN5 acetylates H3K14. Acetylated ISWI represents a minor species associated with the NURF complex. In vitro acetyltransferase assay, mass spectrometry, in vivo acetylation detection BMC molecular biology Medium 17760996
2009 Xenopus/Drosophila ISWI (ortholog of SMARCA1) is a RanGTP-dependent microtubule-associated protein required for chromosome segregation. Recombinant ISWI induces MT nucleation, stabilization, and bundling in vitro. Depletion in Xenopus egg extracts leads to spindle MT disappearance and failed chromosome segregation in anaphase; depletion in Drosophila S2 cells causes spindle defects and growth arrest. ISWI localizes to spindles during mitosis, distinct from its interphase chromatin role. Xenopus egg extract depletion, in vitro MT assembly assay, RNAi in Drosophila S2 cells, live imaging The Journal of cell biology High 20008562
2012 ISWI (ortholog of SMARCA1) is regulated by two conserved inhibitory domains: AutoN (inhibits ATP hydrolysis) and NegC (uncouples ATP hydrolysis from productive DNA translocation). The H4 basic patch on nucleosomes antagonizes AutoN, and extranucleosomal DNA antagonizes NegC, enabling remodeling only on appropriate chromatin substrates. Mutation or removal of AutoN and NegC confers SWI/SNF-like biochemical attributes on ISWI. ATPase assays, nucleosome sliding assays, domain deletion/mutagenesis in Drosophila ISWI Nature High 23143334
2016 Crystal structures of ISWI from thermophilic yeast Myceliophthora thermophila reveal that the AutoN domain contains two inhibitory elements that bind the second RecA-like domain (core2), holding ISWI in an inactive conformation. The histone H4 peptide binds to core2 at a site coincident with one AutoN-binding site, explaining H4-tail-dependent activation. The NegC domain contacts core2 as an allosteric element responding to extranucleosomal DNA length. X-ray crystallography, structure-function mutagenesis, peptide binding assays Nature High 27919072
2019 Cryo-EM structures of yeast ISW1 (ISWI ortholog of SMARCA1) in ADP-bound and ADP-BeFx-bound states show that nucleosome binding activates ISW1 via substantial rearrangement of catalytic domains. The AutoN domain packs against the first RecA-like core and NegC becomes disordered upon activation. Local DNA distortion and translocation occurs without notable histone deformation, suggesting a general mechanism of chromatin remodeling involving DNA distortion independent of histone displacement. Cryo-EM at 3.3 Å resolution, crosslinking assays to prevent histone distortion Nature structural & molecular biology High 30872815
2017 Mapping of the H4-tail binding pocket of ISWI (ortholog of SMARCA1) reveals that AutoN does not act as a simple pseudosubstrate competing with H4. Instead, AutoN cooperates with a second motif (AcidicN) to confer H4-tail sensitivity and discriminate nucleosomes from free DNA. A third N-terminal region motif (ppHSA) stabilizes the NTR by clamping it to Lobe 2 of the ATPase domain and is required in vivo. Mutagenesis, in vitro ATPase and sliding assays, cross-linking, in vivo complementation in Drosophila eLife High 28109157
2017 Each endogenously expressed ISWI ATPase (including SNF2L/SMARCA1) co-purifies with every regulatory subunit, substantially expanding the diversity of ISWI complexes beyond previously known pairings. SNF2L forms stable, direct complexes with all tested regulatory subunits. BAZ2B was identified as a novel seventh regulatory subunit. Reconstituted human ISWI complexes containing SNF2L showed nucleosome remodeling activity. Endogenous co-purification, reconstitution of catalytically active complexes, nucleosome remodeling assays EMBO reports Medium 28801535
2016 Whole-genome sequencing of multiplex families with psychotic disorders identified a novel private missense variant in SMARCA1 (on the X chromosome) segregating with illness in four affected siblings and their unaffected mother. The variant alters the SMARCA1 protein sequence and is considered a candidate causal mutation for schizophrenia spectrum disorders in this family. Whole-genome sequencing, familial segregation analysis Molecular psychiatry Low 27001614
2018 LncRNA DLEU1 promotes colorectal cancer progression by recruiting SMARCA1 (SNF2L, a subunit of the NURF chromatin remodeling complex) to the promoter of KPNA3, activating its transcription. Biotin-coupled probe pulldown, RNA immunoprecipitation, and FISH confirmed direct interaction between DLEU1 and SMARCA1. DLEU1 knockdown reduced SMARCA1 deposition at the KPNA3 promoter. RNA immunoprecipitation, biotin-probe pulldown, ChIP, FISH, shRNA knockdown with phenotypic rescue Molecular cancer Medium 30098595
2017 Review and genetic analysis of Smarca1 knockout mice establishes that SMARCA1 (SNF2L) is required for proper brain development. Loss of SMARCA1 function has been implicated in neurodevelopmental disorders, and ISWI complex-mediated nucleosome positioning within gene regulatory elements is important for the transition from committed neural progenitor states to differentiated cell states. Mouse knockout analysis, genetic studies Molecular and cellular neurosciences Low 29249292

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2016 ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 1233 26777405
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2006 A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 918 16728976
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2005 The DNA sequence of the human X chromosome. Nature 816 15772651
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2010 Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 639 20850016
2018 Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Cell 586 30343899
1997 ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 527 9230310
2009 The SWI/SNF complex and cancer. Oncogene 470 19234488
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
1997 Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Nature 436 9252192
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1984 Five SWI genes are required for expression of the HO gene in yeast. Journal of molecular biology 373 6436497
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
1999 Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer. Cell 296 10399913
2018 The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature 256 30401838
2014 SWI/SNF chromatin remodeling and human malignancies. Annual review of pathology 250 25387058
2002 An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nature genetics 249 12434153
2021 Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 246 34937944
2006 Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome. Nature structural & molecular biology 213 16518397
2019 Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4. Molecular cancer 204 30922402
2019 Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors. Nature 204 30996347
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2003 PIE1, an ISWI family gene, is required for FLC activation and floral repression in Arabidopsis. The Plant cell 200 12837955
2003 SWI/SNF unwraps, slides, and rewraps the nucleosome. Molecular cell 195 12620227
2002 WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. The EMBO journal 194 11980720
2020 COMPASS and SWI/SNF complexes in development and disease. Nature reviews. Genetics 192 32958894
2012 Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America 185 22233809
1996 DNA-binding properties of the yeast SWI/SNF complex. Nature 184 8587611
2002 Modulation of ISWI function by site-specific histone acetylation. EMBO reports 180 11882543
2017 Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders. Frontiers in molecular neuroscience 174 28824374
2014 Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Molecular cell 173 25544563
2001 When the SWI/SNF complex remodels...the cell cycle. Oncogene 171 11420722
2020 UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination. Nature cell biology 168 32807901
2001 Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors. Journal of cell science 162 11683384
2014 A rationale to target the SWI/SNF complex for cancer therapy. Trends in genetics : TIG 153 24932742
2003 Isolation of human NURF: a regulator of Engrailed gene expression. The EMBO journal 145 14609955
2019 Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer. Genes & development 144 31123059
2002 SWI/SNF chromatin remodeling and cancer. Current opinion in genetics & development 143 11790558
2012 SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions. The Journal of biological chemistry 139 22952240
2018 Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Molecular cell 136 30554943
2014 SWI/SNF chromatin remodeling complexes and cancer. American journal of medical genetics. Part C, Seminars in medical genetics 134 25169151
2002 Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics 132 12112843
2014 The central role of EED in the orchestration of polycomb group complexes. Nature communications 131 24457600
2020 Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Nature 129 32188938
2012 Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes. Nature 128 23143334
2022 Human transcription factor protein interaction networks. Nature communications 123 35140242
2021 Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy. Oncogene 123 33941852
2003 Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme. Molecular and cellular biology 123 12612068
2005 CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. Human molecular genetics 122 15640247
2015 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Molecular systems biology 120 25609649
2018 LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3. Molecular cancer 115 30098595
2013 Linking the SWI/SNF complex to prostate cancer. Nature genetics 114 24165726
2008 Architecture of the SWI/SNF-nucleosome complex. Molecular and cellular biology 111 18644858
2016 PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease. Biochemistry 110 26836503
2020 Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. Nature 106 32188943
2007 SWI/SNF chromatin remodeling and linker histones in plants. Biochimica et biophysica acta 102 17292979
2006 Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control. Molecular and cellular biology 101 17101803
2005 BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF. Molecular and cellular biology 98 15743818
2014 ISWI chromatin remodeling complexes in the DNA damage response. Cell cycle (Georgetown, Tex.) 97 25486562
2019 SWI/SNF: Complex complexes in genome stability and cancer. DNA repair 89 30897376
2016 The Role of SWI/SNF Chromatin Remodeling Complexes in Hormone Crosstalk. Trends in plant science 88 26920655
2019 Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nature structural & molecular biology 84 30872815
2007 A novel ISWI is involved in VSG expression site downregulation in African trypanosomes. The EMBO journal 84 17431399
2016 Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness. Molecular psychiatry 83 27001614
2017 Expansion of the ISWI chromatin remodeler family with new active complexes. EMBO reports 81 28801535
2011 Chromatin remodelling in mammalian cells by ISWI-type complexes--where, when and why? The FEBS journal 77 21810179
2016 Structure and regulation of the chromatin remodeller ISWI. Nature 74 27919072
1999 The mammalian SWI/SNF complex and the control of cell growth. Seminars in cell & developmental biology 73 10441072
2017 Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex. Cell reports 71 28249160
2013 ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. PLoS genetics 70 23468649
2021 The emerging role of ISWI chromatin remodeling complexes in cancer. Journal of experimental & clinical cancer research : CR 68 34736517
2004 Functional diversity of ISWI complexes. Biochemistry and cell biology = Biochimie et biologie cellulaire 68 15284901
1998 Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI. Cytogenetics and cell genetics 68 9730600
2020 SWI/SNF Complex Mutations in Gynecologic Cancers: Molecular Mechanisms and Models. Annual review of pathology 66 31977292
2017 TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene 66 28068325
2019 FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex. EMBO reports 65 30962207
2023 Global identification of SWI/SNF targets reveals compensation by EP400. Cell 64 37922899
2014 Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair. The Journal of cell biology 64 25533843
2023 The Role and Activity of SWI/SNF Chromatin Remodelers. Annual review of plant biology 63 36889009
2014 Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription. Nucleic acids research 62 24990377
2017 Composition and Function of Mutant Swi/Snf Complexes. Cell reports 61 28249159
2023 Mitotic bookmarking by SWI/SNF subunits. Nature 56 37225980
2020 Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription. Genes & development 55 33303640
2019 Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome. Nature structural & molecular biology 55 30664740
2013 The SWI/SNF genetic blockade: effects in cell differentiation, cancer and developmental diseases. Oncogene 55 23752187
2017 The role of ISWI chromatin remodeling complexes in brain development and neurodevelopmental disorders. Molecular and cellular neurosciences 54 29249292
2023 Epigenetic pioneering by SWI/SNF family remodelers. Molecular cell 52 38016477
2023 SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities. Molecular cancer 51 36810086
2018 Hereditary SWI/SNF complex deficiency syndromes. Seminars in diagnostic pathology 50 29397238
2022 NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. Molecular cell 47 35537449
2009 Functional interplay between chromatin remodeling complexes RSC, SWI/SNF and ISWI in regulation of yeast heat shock genes. Nucleic acids research 47 20015969
2024 Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 46 38538798
2019 Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner. Clinical cancer research : an official journal of the American Association for Cancer Research 45 30723142
2001 The interactions of yeast SWI/SNF and RSC with the nucleosome before and after chromatin remodeling. The Journal of biological chemistry 45 11304548
2009 ISWI is a RanGTP-dependent MAP required for chromosome segregation. The Journal of cell biology 44 20008562
2020 Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. The Plant cell 42 32358072
2017 The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. Stem cells (Dayton, Ohio) 42 28276606
2013 The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond. Nucleus (Austin, Tex.) 42 24145903
2015 Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation. Frontiers in oncology 41 25774356
2018 SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications. Molecular cancer research : MCR 39 30037854
2014 The silencing of the SWI/SNF subunit and anticancer gene BRM in Rhabdoid tumors. Oncotarget 39 24913006
2007 Site-specific acetylation of ISWI by GCN5. BMC molecular biology 38 17760996
2004 ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays. The Journal of biological chemistry 38 15201272
2005 Chromatin remodeling by WSTF-ISWI at the replication site: opening a window of opportunity for epigenetic inheritance? Cell cycle (Georgetown, Tex.) 35 15753658
2010 SWI/SNF complexes, chromatin remodeling and skeletal myogenesis: it's time to exchange! Experimental cell research 33 20553711
2024 Targeting SWI/SNF Complexes in Cancer: Pharmacological Approaches and Implications. Epigenomes 31 38390898
2014 ISWI chromatin remodeling: one primary actor or a coordinated effort? Current opinion in structural biology 31 24561830
2014 Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5. PloS one 30 24498324
2011 The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. Molecular biology of the cell 29 21900490
2022 SWI/SNF senses carbon starvation with a pH-sensitive low-complexity sequence. eLife 28 35129437
2012 Disparity in the DNA translocase domains of SWI/SNF and ISW2. Nucleic acids research 28 22298509
2003 Selective gene regulation by SWI/SNF-related chromatin remodeling factors. Current topics in microbiology and immunology 28 12596906
2014 Investigating the interactions of yeast prions: [SWI+], [PSI+], and [PIN+]. Genetics 27 24727082
2023 SWI/SNF Chromatin Remodelers: Structural, Functional and Mechanistic Implications. Cell biochemistry and biophysics 26 37119511
2014 Regulation of ISWI chromatin remodelling activity. Chromosoma 26 24414837
2023 The esBAF and ISWI nucleosome remodeling complexes influence occupancy of overlapping dinucleosomes and fragile nucleosomes in murine embryonic stem cells. BMC genomics 24 37055726
2022 Emerging Themes in Mechanisms of Tumorigenesis by SWI/SNF Subunit Mutation. Epigenetics insights 24 35911061
2022 Paraspeckles interact with SWI/SNF subunit ARID1B to regulate transcription and splicing. EMBO reports 24 36354291
2021 SWI/SNF-deficient thoraco-pulmonary neoplasms. Seminars in diagnostic pathology 24 33451916
2017 Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail. eLife 24 28109157
2025 Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex. Epigenetics & chromatin 23 40269969
2007 ISWI chromatin remodeling in ovarian somatic and germ cells: revenge of the NURFs. Trends in endocrinology and metabolism: TEM 23 17544291