Affinage

SLC4A1

Band 3 anion transport protein · UniProt P02730

Length
911 aa
Mass
101.8 kDa
Annotated
2026-06-10
100 papers in source corpus 13 papers cited in narrative 13 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC4A1 (Band 3/AE1) is an electroneutral Cl-/HCO3- anion exchanger whose membrane domain forms dimers and translocates anions by an alternating-access cycle through outward-facing, occluded, and inward-facing states (PMID:27058983, PMID:35283786). Crystallographic analysis of the dimeric membrane domain defined the anion-binding and translocation residues, N-glycosylation and protease cleavage sites, and the positions of disease-causing mutations (PMID:27058983). In erythrocytes, AE1 transport activity is supported by accessory protein partners: glycophorin A associates with AE1 to maintain high anion-transport activity and proper structural organization of the transport site (PMID:14604989), an interaction mediated by an ionic bond between Glu658 of AE1 and Arg61 of GPA that constitutes the Wright blood group antigen (PMID:30011272, PMID:982531), and stomatin directly binds AE1 and upregulates its Cl-/HCO3- exchange (PMID:23219802, PMID:28387307). AE1 does not require a physical metabolon with carbonic anhydrase II for bicarbonate transport (PMID:23878365). In the kidney, the AE1 isoform is required for distal bicarbonate regeneration: its loss causes distal renal tubular acidosis with hyperchloremic metabolic acidosis, nephrocalcinosis, and dysregulated aquaporin-2 localization (PMID:17409310). SLC4A1 mutations cause distal renal tubular acidosis, with dominant alleles retained in the ER and trapping wild-type protein in heterodimers (dominant-negative) while recessive alleles are retained in the Golgi or degraded yet rescued by wild-type co-expression (PMID:19565014, PMID:14736961, PMID:15211439).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1976 Medium

    Establishing that the Wright blood group antigens depend on the Band 3/AE1 gene product linked a serologically defined antigen system to a specific erythrocyte membrane protein.

    Evidence Serological testing of En(a-) and heterozygote red cells with anti-Wra/anti-Wrb and enzyme treatments

    PMID:982531

    Open questions at the time
    • Did not define the molecular interface generating the antigen
    • No transport-function correlate established
  2. 2003 High

    Showing that GPA-deficient red cells have impaired anion transport established that glycophorin A association is functionally required for full AE1 transport activity and structural organization, not merely a passive neighbor.

    Evidence Sulfate/iodide transport assays and fluorescence structural probes in GPA-deficient red cells

    PMID:14604989

    Open questions at the time
    • Molecular basis of the GPA-AE1 contact not resolved here
    • Did not distinguish direct allosteric effect from membrane organization
  3. 2004 Medium

    Linking specific dRTA mutations to reduced red cell sulfate influx and to absence of AE1 from intercalated cells in vivo connected genotype to both transport defect and mislocalization.

    Evidence Sulfate influx in patient red cells with compound heterozygous mutations; immunocytochemistry of human kidney with R589H

    PMID:14736961 PMID:15211439

    Open questions at the time
    • Single families/cases
    • Did not resolve the cellular trafficking itinerary of mutants
  4. 2005 High

    Systematic trafficking analysis of dominant vs recessive kAE1 mutants explained the genetics of dRTA: dominant mutants are ER-retained and trap wild-type in heterodimers, whereas recessive mutants are rescued by wild-type co-expression.

    Evidence Transfection of polarized/non-polarized cells with immunofluorescence localization, transport assays, and mutant/wild-type co-expression

    PMID:19565014

    Open questions at the time
    • Performed in cultured cell lines rather than native intercalated cells
    • Mechanism of differential ER vs Golgi retention not defined
  5. 2007 High

    Knockout of slc4a1 in mice established that AE1 is required for distal renal bicarbonate regeneration and revealed downstream consequences on water handling.

    Evidence Slc4a1 knockout mouse with collecting duct Cl-/HCO3- exchange assay and aquaporin-2 immunolocalization

    PMID:17409310

    Open questions at the time
    • Mechanism linking AE1 loss to aquaporin-2 dysregulation unresolved
    • Did not address human-specific allele behavior
  6. 2012 Medium

    Identifying stomatin as a direct Band 3 partner in native erythrocyte membranes added a candidate regulator of AE1 within membrane complexes.

    Evidence In situ cross-linking, immunoaffinity purification, and mass spectrometry of erythrocyte membranes

    PMID:23219802

    Open questions at the time
    • Functional consequence not tested in this study
    • Single lab, single primary method
  7. 2013 High

    Testing the proposed AE1-CAII metabolon excluded a required physical interaction, refining the model of how bicarbonate transport couples to carbonic anhydrase activity.

    Evidence FRET, Co-IP, and stopped-flow HCO3- permeability in tsA201 cells and CAII-deficient human red cells

    PMID:23878365

    Open questions at the time
    • Does not exclude transient or low-affinity coupling below detection
    • Total CA activity dependence mechanism not fully resolved
  8. 2016 High

    The crystal structure of the dimeric AE1 membrane domain provided the atomic framework mapping anion-binding/translocation residues, antigen sites, and disease mutations onto a defined fold.

    Evidence Crystal structure determination with MD simulations and integration of cysteine/glycosylation mutagenesis

    PMID:27058983

    Open questions at the time
    • Captures limited conformational states
    • Cytoplasmic domain and full-length assembly not resolved
  9. 2017 High

    Demonstrating that stomatin overexpression increases and stomatin deficiency decreases AE1 anion exchange established stomatin as a positive functional modulator of transport.

    Evidence Stopped-flow fluorimetry in HEK293 and red cell ghosts plus in situ proximity ligation assay

    PMID:28387307

    Open questions at the time
    • Structural basis of stomatin modulation unknown
    • Physiological context of regulation not defined
  10. 2018 Medium

    MD simulations in an asymmetric bilayer defined specific lipid enrichments around AE1 and resolved the Glu658-Arg61 ionic bond underlying the GPA/Wright antigen interaction and higher-order Band 3-GPA strand assembly.

    Evidence Large-scale molecular dynamics simulations with phospholipids, cholesterol, and glycophorin A

    PMID:30011272

    Open questions at the time
    • No orthogonal experimental validation of lipid enrichment in this study
    • Functional impact of specific lipids on transport not measured directly
  11. 2021 Medium

    A minigene splicing assay revealed that a dRTA-associated variant acts through aberrant pre-mRNA splicing, broadening the mutational mechanisms beyond trafficking and transport defects.

    Evidence Minigene splicing assay with bioinformatic prediction of splicing regulatory elements for c.1765C>T

    PMID:34157794

    Open questions at the time
    • Single method without patient RNA confirmation
    • Quantitative effect on protein output not measured
  12. 2022 Low

    MD studies articulated AE1 cycling through outward-facing, occluded, and inward-facing states, framing the alternating-access transport mechanism.

    Evidence Molecular dynamics simulations of conformational states and lipid-protein interactions

    PMID:35283786

    Open questions at the time
    • Computational, no direct experimental validation in this paper
    • Kinetics of state transitions not measured

Open questions

Synthesis pass · forward-looking unresolved questions
  • How accessory partners (GPA, stomatin) and membrane lipids mechanistically couple to the conformational cycle, and how distinct dRTA alleles produce their precise trafficking fates in native intercalated cells, remain unresolved.
  • No structure of AE1 in complex with stomatin or GPA
  • Mechanism of allele-specific ER vs Golgi retention not defined in vivo
  • Direct experimental capture of transport intermediate states lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3 GO:0140104 molecular carrier activity 2
Localization
GO:0005886 plasma membrane 3 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1643685 Disease 2 R-HSA-382551 Transport of small molecules 2
Partners
GYPASTOM
Complex memberships
Band 3-glycophorin A complex (Wright antigen)

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 Crystal structure of the dimeric membrane domain of human Band 3 (AE1, SLC4A1) revealed key structural features responsible for anion binding and translocation, identified locations of blood group antigens, N-glycosylation site, protease cleavage sites, inhibitor and chemical labeling sites, and disease-causing mutations (Southeast Asian ovalocytosis, hereditary stomatocytosis, hereditary spherocytosis, distal renal tubular acidosis) within the structure. Crystal structure determination, molecular dynamics simulations, integration of scanning cysteine and N-glycosylation mutagenesis data Biochimica et biophysica acta High 27058983
2007 Knockout of slc4a1 (AE1) in mice caused distal renal tubular acidosis with hyperchloremic metabolic acidosis, alkaline urine, reduced basolateral Cl-/HCO3- exchange activity in acid-secretory intercalated cells of the medullary collecting duct, nephrocalcinosis, and dysregulated aquaporin-2 localization, establishing that AE1 is required for distal renal bicarbonate regeneration. Slc4a1 knockout mouse model, isolated superfused medullary collecting duct Cl-/HCO3- exchange assay, immunolocalization of aquaporin-2 Journal of the American Society of Nephrology : JASN High 17409310
2013 FRET measurements and immunoprecipitation in tsA201 cells expressing fluorescent fusion proteins showed no detectable physical interaction between AE1 and cytosolic carbonic anhydrase II (CAII); AE1-mediated HCO3- transport was positively correlated with total intracellular CA activity but did not require a CAII-AE1 metabolon. CAII-deficient human red cells had HCO3- permeability indistinguishable from normal cells, providing no support for a functionally important AE1-CAII physical interaction. FRET (Förster resonance energy transfer), immunoprecipitation with Flag-tagged AE1, stopped-flow HCO3- permeability measurements in tsA201 cells and human red cells, non-catalytic CAII mutant overexpression The Journal of physiology High 23878365
2012 In situ chemical cross-linking of erythrocyte membranes followed by immunoaffinity purification and mass spectrometry identified stomatin as a direct interaction partner of band 3 (AE1, SLC4A1) in erythrocyte membrane complexes. In situ chemical cross-linking, immunoaffinity chromatography, mass spectrometry Biochimica et biophysica acta Medium 23219802
2017 Stomatin directly interacts with AE1 (SLC4A1) and modulates its transport activity: overexpression of stomatin in HEK293 cells increased AE1-dependent Cl-/HCO3- exchange permeability by ~30%; stomatin-deficient red cell ghosts showed ~42-47% decreased HCO3- and Cl- permeability. In situ Proximity Ligation Assays confirmed the AE1-stomatin interaction in both HEK cells and red blood cells. Stopped-flow fluorimetry in HEK293 cells and red cell ghosts, in situ Proximity Ligation Assay, recombinant overexpression Scientific reports High 28387307
2003 Band 3 (AE1) in red cells lacking glycophorin A (GPA) exhibited reduced anion transport (sulfate, iodide, chloride) with increased apparent Km or reduced Vmax, and increased flexibility in the region of the transport site (EMA-binding region), indicating that GPA association supports high anion transport activity and proper structural organization of band 3. Sulfate and iodide transport assays in GPA-deficient red cells (MkMk, En(a-), MiV cells), eosin-5-maleimide fluorescence quenching, fluorescence polarization The Journal of biological chemistry High 14604989
2018 Molecular dynamics simulations of Band 3 (AE1) in an asymmetric lipid bilayer showed enrichment of phosphatidylserine and PIP2 in the annular inner leaflet around Band 3, and enrichment of cholesterol at the dimer interface. GPA was shown to associate with Band 3 via an ionic bond between Glu658 in Band 3 and Arg61 in GPA to form the Wright (Wr) blood group antigen complex; large-scale simulations showed GPA dimers bridge Band 3 dimers forming long alternating strands. Molecular dynamics simulations in asymmetric lipid bilayer containing phospholipids, cholesterol, and glycophorin A PLoS computational biology Medium 30011272
2022 Molecular dynamics simulations showed Band 3 (AE1) operates by an alternating access transport mechanism, cycling between outward-facing, occluded anion-bound, and inward-facing conformational states, and revealed specific lipid-protein interactions influencing transport. Molecular dynamics simulations Frontiers in physiology Low 35283786
2005 Dominant dRTA-causing kAE1 mutants (R589H, R901X, S613F) are retained in the ER in cultured polarized and non-polarized cells, while R901X and G609R are mis-targeted to the apical membrane; heterodimers of dominant mutant kAE1 with wild-type protein are intracellularly retained (dominant-negative effect). Recessive mutants G701D (retained in Golgi) and S773P (impaired ER exit, degraded by proteasome) form heterodimers with wild-type kAE1 that traffic to the plasma membrane (dominant-positive/rescue effect), explaining why heterozygotes are unaffected. Transfection of polarized and non-polarized cultured cells, immunofluorescence/immunostaining of intracellular localization, anion transport assays, co-expression studies of mutant and wild-type kAE1 Journal of molecular and genetic medicine : an international journal of biomedical research High 19565014
2021 Minigene splicing assay demonstrated that the SLC4A1 variant c.1765C>T (p.Arg589Cys) causes exon skipping by disrupting exonic splicing enhancers (ESEs) or generating exonic splicing silencers, providing a pre-mRNA splicing mechanism for this dRTA-associated mutation. Minigene splicing assay, bioinformatics prediction of splicing regulatory elements Human mutation Medium 34157794
2004 In a family with dominant dRTA carrying AE1 R589H mutation, immunostaining of kidney cortex showed absence of detectable AE1 polypeptide in vH+-ATPase-positive intercalated cells, confirming that the R589H mutation prevents AE1 from reaching the basolateral membrane of intercalated cells in vivo. Immunocytochemistry of kidney tissue with AE1 and vH+-ATPase antibodies Nephrology, dialysis, transplantation Medium 14736961
1976 Red blood cells with the En(a-) phenotype (lacking the band 3/AE1 Ena antigen) are phenotypically Wr(a-b-), and En(a-)En heterozygotes express only a single dose of Wrb antigen, establishing that the Wright (Wra/Wrb) blood group antigens are dependent on the presence of the Ena (band 3/AE1) gene product for their expression. Serological testing of En(a-) and En heterozygote red cells with anti-Wra and anti-Wrb antibodies; neuraminidase, trypsin, and ficin treatment experiments Transfusion Medium 982531
2004 Novel compound heterozygous SLC4A1 mutations G701D/S773P and SAO/R602H in Thai patients with AR dRTA were associated with reduced red cell sulfate influx, confirming that these mutations impair the anion exchange function of AE1. Sulfate influx assay in patient red cells, molecular genetic sequencing, clinical phenotyping American journal of kidney diseases Medium 15211439

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context. Biochimica et biophysica acta 161 27058983
2003 Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia 132 12592335
2018 The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway. EBioMedicine 115 30448228
2007 Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). Journal of the American Society of Nephrology : JASN 105 17409310
2005 Conifer root and butt rot caused by Heterobasidion annosum (Fr.) Bref. s.l. Molecular plant pathology 97 20565666
2016 Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. Brain, behavior, and immunity 93 27647532
2003 IMGT databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr. Leukemia 89 12529691
1990 Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990. Digestive diseases and sciences 84 2226098
1997 Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. International journal of radiation biology 69 9120355
2012 Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains. Biochimica et biophysica acta 68 23219802
2014 Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. Food & function 61 25288148
2010 Intracellular localisation, geno- and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480). Toxicology letters 58 20600712
2003 Differences in virus-induced cell morphology and in virus maturation between MVA and other strains (WR, Ankara, and NYCBH) of vaccinia virus in infected human cells. Journal of virology 58 12970445
1986 Protection by WR-2721 of human bone marrow function following irradiation. International journal of radiation oncology, biology, physics 57 2428794
1986 A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327. Radiation research 57 3010368
2014 Antihyperlipidemic and hepatoprotective activities of mycelia zinc polysaccharide from Pholiota nameko SW-02. International journal of biological macromolecules 50 25077837
2008 Targeting the folate receptor (FR): imaging and cytotoxicity of ReI conjugates in FR-overexpressing cancer cells. ChemMedChem 50 18651631
1984 WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x rays. International journal of radiation oncology, biology, physics 46 6323362
2011 The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differentiation of human liposarcoma cells (SW 872). PloS one 44 22205965
2010 Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake. Biomacromolecules 43 20687544
1982 Triton WR-1339, a lysosomotropic compound, is excreted into bile and alters the biliary excretion of lysosomal enzymes and lipids. Hepatology (Baltimore, Md.) 41 6802741
2013 Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1. The Journal of physiology 40 23878365
1983 WR-2721, its derivatives and their radioprotective effects on mammalian cells in culture. International journal of radiation biology and related studies in physics, chemistry, and medicine 40 6305861
1994 [Transformation of NIH/3T3 cells and SW 480 cells displaying K-ras mutation]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 39 7882132
1996 Delay or inhibition of rat lens opacification using pantethine and WR-77913. Experimental eye research 38 8674515
2004 Novel compound heterozygous SLC4A1 mutations in Thai patients with autosomal recessive distal renal tubular acidosis. American journal of kidney diseases : the official journal of the National Kidney Foundation 37 15211439
1998 Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutation research 37 9541656
1996 WR-1065 and radioprotection of vascular endothelial cells. I. Cell proliferation, DNA synthesis and damage. Radiation research 37 8606931
1976 The phenotypes En(a-), Wr(a-b-), and En(a+), Wr(a+b-), and further studies on the Wright and En blood group systems. Transfusion 37 982531
2005 Molecular mechanisms of autosomal dominant and recessive distal renal tubular acidosis caused by SLC4A1 (AE1) mutations. Journal of molecular and genetic medicine : an international journal of biomedical research 36 19565014
1998 Chemoprotection in anticancer therapy: the emerging role of amifostine (WR-2721). Anticancer research 36 9703784
1999 Vaccinia virus WR gene A5L is required for morphogenesis of mature virions. Journal of virology 35 10233918
1995 Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278. Carcinogenesis 35 8603486
2018 The Sw-5 Gene Cluster: Tomato Breeding and Research Toward Orthotospovirus Disease Control. Frontiers in plant science 33 30073012
2003 Altered structure and anion transport properties of band 3 (AE1, SLC4A1) in human red cells lacking glycophorin A. The Journal of biological chemistry 33 14604989
1993 Analysis of RNA phage fr coat protein assembly by insertion, deletion and substitution mutagenesis. Protein engineering 33 8309936
2020 Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions. ACS chemical biology 32 32320205
2018 Interaction of the human erythrocyte Band 3 anion exchanger 1 (AE1, SLC4A1) with lipids and glycophorin A: Molecular organization of the Wright (Wr) blood group antigen. PLoS computational biology 32 30011272
2016 Development of Streptomyces sp. FR-008 as an emerging chassis. Synthetic and systems biotechnology 32 29062944
2008 WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free radical biology & medicine 32 18845240
1994 D-penicillamine- and quinidine-induced antinuclear antibodies in A.SW (H-2s) mice: similarities with autoantibodies in spontaneous and heavy metal-induced autoimmunity. European journal of immunology 31 8125139
2017 Stomatin modulates the activity of the Anion Exchanger 1 (AE1, SLC4A1). Scientific reports 28 28387307
1992 Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil. International journal of radiation oncology, biology, physics 28 1312075
2017 Biosynthesis of gold and selenium nanoparticles by purified protein from Acinetobacter sp. SW 30. Enzyme and microbial technology 27 29421042
2010 The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8). Experimental dermatology 27 20201958
2004 Characterization of a highly polymorphic marker adjacent to the SLC4A1 gene and of kidney immunostaining in a family with distal renal tubular acidosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 27 14736961
2002 Bleomycin genotoxicity and amifostine (WR-2721) cell protection in normal leukocytes vs. K562 tumoral cells. Biochemical pharmacology 27 11911849
1989 Radiosensitisation and radioprotection by BSO and WR-2721: the role of oxygenation. British journal of cancer 26 2553091
1982 Influence of WR 2721 on the efficacy of radiotherapy and chemotherapy of murine tumors. International journal of radiation oncology, biology, physics 26 6286550
2013 AMP-activated protein kinase mediates insulin-like and lipo-mobilising effects of β-glucan-rich polysaccharides isolated from Pleurotus sajor-caju (Fr.), Singer mushroom, in 3T3-L1 cells. Food chemistry 25 24128468
2002 Kinetic analysis of the reactions of 4-hydroperoxycyclophosphamide and acrolein with glutathione, mesna, and WR-1065. Drug metabolism and disposition: the biological fate of chemicals 25 12124304
1996 WR-1065 and radioprotection of vascular endothelial cells. II. Morphology. Radiation research 25 8606932
2021 Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice. Journal of ethnopharmacology 24 33640441
2021 Tenuazonic Acid-Triggered Cell Death Is the Essential Prerequisite for Alternaria alternata (Fr.) Keissler to Infect Successfully Host Ageratina adenophora. Cells 23 33922952
2016 Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncology letters 23 27313717
2019 Activation of lncRNA lnc-SLC4A1-1 induced by H3K27 acetylation promotes the development of breast cancer via activating CXCL8 and NF-kB pathway. Artificial cells, nanomedicine, and biotechnology 22 31556319
2018 Glucocorticoid signaling regulates cell invasion and migration in the human first-trimester trophoblast cell line Sw.71. American journal of reproductive immunology (New York, N.Y. : 1989) 22 29774963
2015 Radioprotector WR-2721 and mitigating peptidoglycan synergistically promote mouse survival through the amelioration of intestinal and bone marrow damage. Journal of radiation research 22 25617317
2009 Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. Applied and environmental microbiology 21 19139241
2022 Lectins ConA and ConM extracted from Canavalia ensiformis (L.) DC and Canavalia rosea (Sw.) DC inhibit planktonic Candida albicans and Candida tropicalis. Archives of microbiology 20 35608680
2021 Identification of seven exonic variants in the SLC4A1, ATP6V1B1, and ATP6V0A4 genes that alter RNA splicing by minigene assay. Human mutation 20 34157794
2015 The anti-membranous glomerulonephritic activity of purified polysaccharides from Irpex lacteus Fr. International journal of biological macromolecules 20 26656595
1986 Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats. International journal of radiation oncology, biology, physics 20 3019964
2012 dRTA and hemolytic anemia: first detailed description of SLC4A1 A858D mutation in homozygous state. European journal of haematology 19 22126643
1999 Characterization of non-peptide bradykinin B2 receptor agonist (FR 190997) and antagonist (FR 173657). Immunopharmacology 19 10596851
1988 Radioprotection of mouse jejunum by WR-2721 and WR-1065: effects on DNA strand-break induction and rejoining. Radiation research 19 2836883
2019 C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast. Journal of agricultural and food chemistry 18 31469960
2015 Moderate Hypoxia Down-Regulates Interleukin-6 Secretion and TLR4 Expression in Human Sw.71 Placental Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 17 26279422
1984 Pulse radiolysis studies of WR-1065. International journal of radiation oncology, biology, physics 17 6480445
2000 Measurement of tafenoquine (WR 238605) in human plasma and venous and capillary blood by high-pressure liquid chromatography. Therapeutic drug monitoring 16 10774631
2022 Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells. ACS chemical neuroscience 15 35114083
2015 Polysaccharide composition of raw and cooked chayote (Sechium edule Sw.) fruits and tuberous roots. Carbohydrate polymers 15 26076612
2011 EGFR activation monitored by SW-FCCS in live cells. Frontiers in bioscience (Elite edition) 15 21196281
1993 Effects of WR-1065 and WR-151326 on survival and neoplastic transformation in C3H/10T1/2 cells exposed to TRIGA or JANUS fission neutrons. International journal of radiation biology 15 8093466
1991 Isolation of a new gene (SW A2) encoding an alpha-amylase from Schwanniomyces occidentalis and its expression in Saccharomyces cerevisiae. FEBS letters 15 1995339
2023 Antifungal activity of volatile and non-volatile metabolites of endophytes of Chloranthus elatior Sw. Frontiers in plant science 14 37265637
2022 Structure and Function Insight of the α-Glucosidase QsGH13 From Qipengyuania seohaensis sp. SW-135. Frontiers in microbiology 14 35308395
2020 Clinical Diagnosis of Red Cell Membrane Disorders: Comparison of Osmotic Gradient Ektacytometry and Eosin Maleimide (EMA) Fluorescence Test for Red Cell Band 3 (AE1, SLC4A1) Content for Clinical Diagnosis. Frontiers in physiology 14 32636758
2017 Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae). Journal of medicinal food 14 28613963
2013 Acute kernicterus in a neonate with O/B blood group incompatibility and a mutation in SLC4A1. Pediatrics 14 23878048
2009 Molecular population genetics of SLC4A1 and Southeast Asian ovalocytosis. Journal of human genetics 14 19229254
1996 YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p. Genomics 14 8838809
1988 Radioprotection of cultured Chinese hamster ovary cells by WR-255591. International journal of radiation biology 14 2900283
2023 Prosopis juliflora (Sw.) DC phytochemicals induce apoptosis and inhibit cell proliferation signaling pathways, EMT, migration, invasion, angiogenesis and stem cell markers in melanoma cell lines. Journal of ethnopharmacology 13 37062530
2021 Chemical profile, antioxidant and anti-inflammatory properties of Miconia albicans (Sw.) Triana (Melastomataceae) fruits extract. Journal of ethnopharmacology 13 33647428
2017 The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer. Journal of experimental & clinical cancer research : CR 13 28095907
2015 Protection of radiation induced DNA and membrane damages by total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst. Chemico-biological interactions 13 25824410
2014 Immunopotentiation of Pleurotus eryngii (DC. ex Fr.) Quel. Journal of ethnopharmacology 13 24650999
2001 Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation. International journal of cancer 13 11992383
1997 Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro. Anti-cancer drugs 13 9147609
1995 The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention. Carcinogenesis 13 7586189
2022 Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility. Frontiers in human neuroscience 12 35845248
2017 In Vitro and In Vivo Activity of Fomitopsis Pinicola (Sw. Ex Fr.) Karst Chloroform (Fpkc) Extract Against S180 Tumor Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 12 29241162
2003 IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr. Novartis Foundation symposium 12 14712935
2002 Relationships between cytoprotection and mutation prevention by WR-1065. Military medicine 12 11873516
1982 Chemical protection against gastrointestinal radiation injury in mice by WR 2822, WR 2823, or WR 109342 after 4 MeV X ray or fission neutron irradiation. International journal of radiation oncology, biology, physics 12 7107377
2022 Role of PsnWRKY70 in Regulatory Network Response to Infection with Alternaria alternata (Fr.) Keissl in Populus. International journal of molecular sciences 11 35886886
2021 Genome-Wide Identification, Structure Characterization, Expression Pattern Profiling, and Substrate Specificity of the Metal Tolerance Protein Family in Canavalia rosea (Sw.) DC. Plants (Basel, Switzerland) 11 34209283
2021 Polyethylene glycol triggers the anti-cancer impact of curcumin nanoparticles in sw-1736 thyroid cancer cells. Journal of materials science. Materials in medicine 11 34453618
2022 Organization and Dynamics of the Red Blood Cell Band 3 Anion Exchanger SLC4A1: Insights From Molecular Dynamics Simulations. Frontiers in physiology 10 35283786

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