Affinage

GYPA

Glycophorin-A · UniProt P02724

Length
150 aa
Mass
16.4 kDa
Annotated
2026-06-10
100 papers in source corpus 7 papers cited in narrative 7 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Glycophorin A (GYPA/GPA/CD235a) is an abundant erythrocyte sialoglycoprotein whose transmembrane domain forms sequence-specific homodimers whose stability is governed by the lipid environment: dimerization is most efficient under hydrophobic-matching conditions, and cholesterol promotes helix self-association by increasing acyl-chain ordering (PMID:20603102). Beyond its own oligomerization, GPA functions as an obligatory partner for the band 3 anion exchanger (AE1/SLC4A1): coexpression of GPA is required for surface trafficking and anion-transport activity (Cl− flux, Cl−/HCO3− exchange, sulfate and oxalate uptake) of the spherostomatocytosis mutant AE1 E758K, while the mutant's cation permeability is GPA-independent (PMID:19907019). A specific GPA epitope involving Ala65 is necessary for this interaction, as an Ala65→Pro substitution disrupts the high-incidence ENEP antigen and aberrantly reduces Wrb expression even when band 3 is normal (PMID:10354388). GPA also serves as the principal erythrocyte attachment site for Plasmodium falciparum: its exon 2-encoded receptor-binding domain shows population-genetic signatures of balancing selection in malaria-endemic regions (PMID:29362874). During erythropoiesis, GPA surface expression marks early definitive erythroblast commitment (PMID:27720903), and GPA-bearing erythrocyte-derived microparticles are shed from growing thrombi and contribute to local procoagulant activity (PMID:26239059). The GYPA locus is subject to gene-conversion exchange with GYPB, generating hybrid genes and antigenic variation (PMID:24916810).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 1999 Medium

    Established that a discrete GPA epitope (residue Ala65) is required for the GPA-band 3 interaction underlying normal Wrb antigen expression, localizing the contact surface to the extracellular domain.

    Evidence DNA sequencing of GYPA and band 3 plus serological antigen typing in unrelated individuals carrying a natural Ala65Pro mutation

    PMID:10354388

    Open questions at the time
    • No in vitro reconstitution of the GPA-band 3 interaction
    • Structural basis of the Ala65 contact not resolved
  2. 2009 High

    Defined GPA as a functional requirement for band 3 surface trafficking and anion transport, distinguishing GPA-dependent (anion) from GPA-independent (cation) activities of the AE1 E758K mutant.

    Evidence Xenopus and Ambystoma oocyte coexpression with 36Cl− flux, 86Rb+ influx, electrophysiology, and pharmacological inhibition

    PMID:19907019

    Open questions at the time
    • Tested with a disease mutant rather than wild-type AE1
    • Molecular mechanism by which GPA chaperones AE1 to the surface unresolved
  3. 2010 Medium

    Showed that GPA transmembrane homodimerization is not intrinsic but tuned by membrane physical state, with hydrophobic matching and cholesterol-driven acyl-chain ordering setting helix-helix stability.

    Evidence Fluorescence spectroscopy of labeled GPA TM peptides in model membranes of varying lipid composition

    PMID:20603102

    Open questions at the time
    • Performed in reconstituted model membranes, not native erythrocyte membranes
    • Functional consequence of lipid-tuned dimerization not assayed
  4. 2014 Medium

    Demonstrated that the GYPA locus generates antigenic and sequence diversity through unequal homologous recombination with GYPB, producing GYPA-B-A hybrid alleles.

    Evidence gDNA and cDNA sequencing with haplotype separation and serological blood group typing

    PMID:24916810

    Open questions at the time
    • Functional impact of the position-13 substitution beyond preserved M/N antigens not assessed
    • Single-lab study
  5. 2015 Medium

    Linked GPA-bearing erythrocyte microparticles to thrombosis, showing they are shed in proportion to thrombus mass and add to procoagulant activity.

    Evidence Ex vivo thrombogenic-surface perfusion with triple-label flow cytometry and thrombin generation assays, validated in STEMI patient blood

    PMID:26239059

    Open questions at the time
    • CD235a used as erythrocyte identity marker rather than functionally manipulated
    • Specific contribution of GPA itself to procoagulant activity not isolated
  6. 2016 Low

    Positioned GPA surface expression as one of the earliest markers of definitive erythroblast commitment during hPSC differentiation.

    Evidence hPSC co-culture differentiation with serial flow cytometry for CD34, CD235a, CD36, and β-globin

    PMID:27720903

    Open questions at the time
    • Marker-based correlation only; no loss-of-function manipulation of GPA
    • Causal role of GPA in commitment not tested
  7. 2018 Low

    Provided population-genetic evidence that GYPA exon 2, the P. falciparum EBA-175 binding domain, is under balancing selection in malaria-endemic populations.

    Evidence Population resequencing and neutrality testing across endemic and non-endemic populations

    PMID:29362874

    Open questions at the time
    • The receptor function is referenced from prior work, not demonstrated here
    • Inference is statistical, not mechanistic

Open questions

Synthesis pass · forward-looking unresolved questions
  • How lipid-tuned GPA dimerization, band 3 chaperoning, and pathogen-receptor function are integrated at the native erythrocyte membrane, and whether GPA loss-of-function alters erythroid commitment, remain unresolved.
  • No structure of the GPA-band 3 complex in the corpus
  • No direct GPA loss-of-function experiment in erythropoiesis
  • Direct biochemical demonstration of EBA-175 binding absent from the timeline

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2 GO:0001618 virus receptor activity 1
Localization
GO:0005886 plasma membrane 5
Partners
SLC4A1

Evidence

Reading pass · 7 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 The GPA (Glycophorin A) transmembrane domain dimerization propensity is strongly influenced by lipid bilayer thickness, with dimerization most efficient under hydrophobic matching conditions. Cholesterol promotes self-association of GPA transmembrane helices by increasing lipid acyl chain ordering. The order of lipid acyl chains is a key determinant of the strength and stability of the GPA TM helix-helix interaction. Fluorescence spectroscopy of fluorescent-labeled GPA transmembrane peptides in model membranes with varying lipid compositions Biochimica et biophysica acta Medium 20603102
2009 The hereditary spherostomatocytosis AE1 mutation E758K requires coexpressed Glycophorin A (GPA) for surface expression in Xenopus oocytes. GPA dependence extends to DIDS-sensitive Cl− influx, trans-anion-dependent Cl− efflux, Cl−/HCO3− exchange, SO4²− uptake, and oxalate uptake activities of the mutant AE1 E758K. By contrast, the Rb+ influx and inward cation currents associated with AE1 E758K expression were largely GPA-independent, indicating that GPA selectively enables surface trafficking and anion transport of this AE1 mutant but is not required for its cation permeability pathway. Xenopus and Ambystoma oocyte expression system with 36Cl− flux assays, 86Rb+ influx assays, electrophysiology, and pharmacological inhibition; coexpression with/without GPA American journal of physiology. Cell physiology High 19907019
1999 A point mutation in GPA (Ala65→Pro) disrupts expression of the high-incidence ENEP antigen and creates a novel low-incidence antigen (HAG), and additionally causes aberrant (reduced) Wrb expression on red blood cells. Since band 3 from the same patient had normal Glu658 (required for Wrb), the altered Wrb expression is directly attributable to the Ala65→Pro mutation in GPA, providing direct evidence that a specific GPA epitope (involving residue Ala65) is necessary for normal Wrb expression — i.e., for the GPA–band 3 interaction required for Wrb. DNA sequencing of GYPA and band 3 genes; serological blood group antigen typing; identification of two unrelated individuals homozygous or heterozygous for the mutation Transfusion medicine (Oxford, England) Medium 10354388
2018 Resequencing of GYPA in populations from P. falciparum endemic and non-endemic regions revealed patterns of variation consistent with balancing selection acting on GYPA in malaria-endemic populations and Europeans. Exon 2 of GYPA, which encodes the receptor-binding domain for P. falciparum EBA-175 (the 175-kDa erythrocyte-binding antigen), shows signatures of selection, consistent with GPA's experimentally established role as the major binding site for P. falciparum on erythrocytes. Population resequencing and population genetics analyses (neutrality tests) across malaria-endemic and non-endemic populations Human genetics Low 29362874
2016 During early erythropoiesis from human pluripotent stem cells (hPSCs), GPA (Glycophorin A/CD235a) is expressed as one of the earliest surface markers of the definitive erythroblast lineage, with initial GPA+CD34lowCD36− cells maturing into GPA+CD36low/+ cells with higher β-globin expression, establishing GPA surface expression as a stage-specific marker functionally linked to erythroid commitment and maturation. hPSC co-culture differentiation system with serial flow cytometric analysis of CD34, GPA/CD235a, CD36, β-globin expression Stem cell reports Low 27720903
2015 Growing thrombi release elevated levels of Glycophorin-A-positive (CD235a+) erythrocyte-derived microparticles (ErMPs) into distal perfusing blood, as shown in ex vivo perfusion experiments and validated in STEMI patient blood. The release of CD235a+ ErMPs is directly related to thrombus mass and plasma procoagulant activity, indicating that GPA-expressing erythrocyte microparticles are shed during thrombosis and contribute to the procoagulant environment. Ex vivo perfusion of thrombogenic surfaces with triple-labeling flow cytometry; thrombin generation assays; validation in STEMI patient coronary and peripheral blood Journal of thrombosis and haemostasis Medium 26239059
2014 Gene conversion events between GYPA and GYPB produce GYPA-B-A hybrid genes via unequal homologous recombination, resulting in a segmental transfer of a GYPB sequence (including intron 1 and exon 2) into GYPA. This causes an amino acid substitution at position 13 (Arg→Glu, c.38C>A) in the GPA protein. Despite this substitution, normal M and N antigen expression is maintained, and the hybrid is associated with a heterozygous deletion of GYPB exon 2 in all probands. Sequence analysis of GYPA exons 1–7 and GYPB exons 1–5 from genomic DNA and cDNA; haplotype separation; serological blood group typing Vox sanguinis Medium 24916810

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS genetics 162 25393678
2004 Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. The EMBO journal 138 14988722
2002 Optical studies of solid hydrogen to 320 GPa and evidence for black hydrogen. Nature 134 11948345
2003 Properties of diamond under hydrostatic pressures up to 140 GPa. Nature materials 106 12612670
1995 Validation and population studies of the loci LDLR, GYPA, HBGG, D7S8, and Gc (PM loci), and HLA-DQ alpha using a multiplex amplification and typing procedure. Journal of forensic sciences 89 7876801
2010 The membrane environment modulates self-association of the human GpA TM domain--implications for membrane protein folding and transmembrane signaling. Biochimica et biophysica acta 81 20603102
2005 Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development (Cambridge, England) 73 16162648
2003 Embryonic handedness choice in C. elegans involves the Galpha protein GPA-16. Development (Cambridge, England) 61 14534142
2006 LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis. Current biology : CB 60 17189697
1993 In vivo somatic mutation and segregation at the human glycophorin A (GPA) locus: phenotypic variation encompassing both gene-specific and chromosomal mechanisms. Mutation research 59 7686259
2021 Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA). Allergo journal international 55 33643776
2023 Diagnosis and treatment of Hymenoptera venom allergy: S2k Guideline of the German Society of Allergology and Clinical Immunology (DGAKI) in collaboration with the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (ABD), the Medical Association of German Allergologists (AeDA), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Allergy and Environmental Medicine (GPA), German Respiratory Society (DGP), and the Austrian Society for Allergy and Immunology (ÖGAI). Allergologie select 51 37854067
2015 Growing thrombi release increased levels of CD235a(+) microparticles and decreased levels of activated platelet-derived microparticles. Validation in ST-elevation myocardial infarction patients. Journal of thrombosis and haemostasis : JTH 49 26239059
2019 Synthesis of clathrate cerium superhydride CeH9 at 80-100 GPa with atomic hydrogen sublattice. Nature communications 48 31575861
2016 Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36. Stem cell reports 46 27720903
2005 Effect of pressure on the crystal structure of L-serine-I and the crystal structure of L-serine-II at 5.4 GPa. Acta crystallographica. Section B, Structural science 46 15659858
1995 Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development. Development (Cambridge, England) 46 7671828
2021 GPA Peptide Attenuates Sepsis-Induced Acute Lung Injury in Mice via Inhibiting Oxidative Stress and Pyroptosis of Alveolar Macrophage. Oxidative medicine and cellular longevity 45 34992715
2007 Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC. Environmental and molecular mutagenesis 44 17358027
2013 Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA). Arthritis research & therapy 43 23799890
2020 GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway. Aging 41 32950971
2023 Stoichiometric Ternary Superhydride LaBeH_{8} as a New Template for High-Temperature Superconductivity at 110 K under 80 GPa. Physical review letters 39 37450815
2010 In situ crystallization of low-melting ionic liquid [BMIM][PF6] under high pressure up to 2 GPa. The journal of physical chemistry. B 37 20353249
2007 Structure of sodium above 100 GPa by single-crystal x-ray diffraction. Proceedings of the National Academy of Sciences of the United States of America 37 17947379
2009 The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes. American journal of physiology. Cell physiology 36 19907019
1996 Mutations affecting the high affinity ATPase center of gpA, the large subunit of bacteriophage lambda terminase, inactivate the endonuclease activity of terminase. Journal of molecular biology 35 8794874
2009 Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms. American journal of physiology. Endocrinology and metabolism 31 19318515
1995 Arab population data on the PCR-based loci: HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80. Journal of forensic sciences 30 7595333
2010 The RNA backbone plays a crucial role in mediating the intrinsic stability of the GpU dinucleotide platform and the GpUpA/GpA miniduplex. Nucleic acids research 29 20223772
1998 Human in vivo somatic mutation measured at two loci: individuals with stably elevated background erythrocyte glycophorin A (gpa) variant frequencies exhibit normal T-lymphocyte hprt mutant frequencies. Mutation research 28 9541637
1994 Swiss population data on the loci HLA-DQ alpha, LDLR, GYPA, HBGG, D7S8, Gc and D1S80. Forensic science international 28 7959474
1993 GPA and CNTF produce similar effects in sympathetic neurones but differ in receptor binding. Neuroreport 28 8298104
2016 Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3. Molecular and cellular probes 26 27559009
2008 Using generalized procrustes analysis (GPA) for normalization of cDNA microarray data. BMC bioinformatics 26 18199333
2020 GPA peptide enhances Nur77 expression in intestinal epithelial cells to exert a protective effect against DSS-induced colitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25 32978839
2022 Anionic N18 Macrocycles and a Polynitrogen Double Helix in Novel Yttrium Polynitrides YN6 and Y2 N11 at 100 GPa. Angewandte Chemie (International ed. in English) 23 35726633
2001 PCR amplification of putative gpa-2 and gpa-3 orthologs from the (A+T)-rich genome of Strongyloides stercoralis. International journal for parasitology 23 11306115
1998 Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia. Infection and immunity 22 9632583
1995 Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA. Gene 22 8566775
1990 Cytochrome c mRNA and alpha-actin mRNA in muscles of rats fed beta-GPA. Journal of applied physiology (Bethesda, Md. : 1985) 22 2174029
2017 Melting and High P-T Transitions of Hydrogen up to 300 GPa. Physical review letters 21 28949699
2016 Generation of pressures over 40 GPa using Kawai-type multi-anvil press with tungsten carbide anvils. The Review of scientific instruments 21 26931871
2014 Viscosity of fluid nitrogen to pressures of 10 GPa. The journal of physical chemistry. B 21 25215593
2019 Observation of methane filled hexagonal ice stable up to 150 GPa. Proceedings of the National Academy of Sciences of the United States of America 19 31332007
2009 X-ray diffraction measurements of Mo melting to 119 GPa and the high pressure phase diagram. The Journal of chemical physics 19 19334853
2007 The DNA maturation domain of gpA, the DNA packaging motor protein of bacteriophage lambda, contains an ATPase site associated with endonuclease activity. Journal of molecular biology 19 17870092
2018 NMR at pressures up to 90 GPa. Journal of magnetic resonance (San Diego, Calif. : 1997) 18 29778072
2017 Concurrent brain radiotherapy and EGFR-TKI may improve intracranial metastases control in non-small cell lung cancer and have survival benefit in patients with low DS-GPA score. Oncotarget 18 29340055
2015 Gene Perturbation Atlas (GPA): a single-gene perturbation repository for characterizing functional mechanisms of coding and non-coding genes. Scientific reports 18 26039571
2015 Melting of iron determined by X-ray absorption spectroscopy to 100 GPa. Proceedings of the National Academy of Sciences of the United States of America 18 26371317
2013 Oxidized eicosapentaenoic acids more potently reduce LXRα-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1β and GPA than its intact form. Lipids in health and disease 18 23680128
2010 Flexibility of the Cu,Zn superoxide dismutase structure investigated at 0.57 GPa. Acta crystallographica. Section D, Biological crystallography 18 20516618
2018 Synthesis of FeN4 at 180 GPa and its crystal structure from a submicron-sized grain. Acta crystallographica. Section E, Crystallographic communications 17 30319786
2017 Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients. Arthritis research & therapy 17 28615072
2005 Xenon melting curve to 80 GPa and 5p-d hybridization. Physical review letters 17 16384508
1999 Interaction of cis- and trans-RuCl2(DMSO)4 with the nucleotides GpA, d(GpA), ApG, d(ApG) and d(CCTGGTCC): high-field NMR characterization of the reaction products. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 17 10499092
2019 Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells. Clinical epigenetics 16 31182156
2016 Self-diffusion of protons in H2O ice VII at high pressures: Anomaly around 10 GPa. The Journal of chemical physics 16 27334175
2013 Equation of state, refractive index and polarizability of compressed water to 7 GPa and 673 K. The Journal of chemical physics 16 23406131
2012 The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a Gαi subunit. Journal of molecular signaling 16 22280843
2011 GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans. Aging cell 16 21108728
2010 Thermodynamic data and modeling of the water and ammonia-water phase diagrams up to 2.2 GPa for planetary geophysics. The Journal of chemical physics 16 20950012
2013 GPA-14, a Gα(i) subunit mediates dopaminergic behavioral plasticity in C. elegans. Behavioral and brain functions : BBF 15 23607404
2001 Platelet storage in PAS-2 or autologous plasma: impact on functional parameters. Transfusion medicine (Oxford, England) 15 11299027
1998 Effect of chronic electrical stimulation and beta-GPA diet on GLUT4 protein concentration in rat skeletal muscle. Acta physiologica Scandinavica 15 9715737
2014 Expression and localization of gonadotropic hormone subunits (Gpa, Fshb, and Lhb) in the pituitary during gonadal differentiation in medaka. General and comparative endocrinology 14 24859259
2014 Prolonged B cell depletion with rituximab is effective in treating refractory pulmonary granulomatous inflammation in granulomatosis with polyangiitis (GPA). Medicine 14 25501085
2009 High-pressure (up to 10.7 GPa) crystal structure of single-component molecular metal [Au(tmdt)2]. Journal of the American Chemical Society 14 19405466
2007 Fabrication and efficiency evaluation of a hybrid NiCrAl pressure cell up to 4 GPa. The Review of scientific instruments 14 17672771
1998 ATP-reactive sites in the bacteriophage lambda packaging protein terminase lie in the N-termini of its subunits, gpA and gpNu1. Virology 14 9705918
2009 Pressure-dependent decomposition kinetics of the energetic material HMX up to 3.6 GPa. The journal of physical chemistry. A 13 19827806
2007 High-pressure studies of cyclohexane to 40 GPa. The journal of physical chemistry. B 13 17407345
1999 Glycophorin A mutation Ala65 --> Pro gives rise to a novel pair of MNS alleles ENEP (MNS39) and HAG (MNS41) and altered Wrb expression: direct evidence for GPA/band 3 interaction necessary for normal Wrb expression. Transfusion medicine (Oxford, England) 13 10354388
2018 Complex signatures of natural selection at GYPA. Human genetics 12 29362874
2017 Water-carbon dioxide solid phase equilibria at pressures above 4 GPa. Scientific reports 12 28400579
2021 Action-at-a-distance mutations at 5'-GpA-3' sites induced by oxidised guanine in WRN-knockdown cells. Mutagenesis 11 34272950
2020 Evaluation of analytical accuracy of HER2 status in patients with breast cancer: Comparison of HER2 GPA with HER2 IHC and HER2 FISH. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 11 32860265
2014 Melting temperatures of H2O up to 72 GPa measured in a diamond anvil cell using CO2 laser heating technique. The Journal of chemical physics 11 24559351
2011 Viscosity of methane to 6 GPa and 673 K. Physical review. E, Statistical, nonlinear, and soft matter physics 11 22304134
2005 Use of the glycophorin A somatic mutation assay for rapid, unambiguous identification of Fanconi anemia homozygotes regardless of GPA genotype. American journal of medical genetics. Part A 11 15822129
1997 Distribution of types for six PCR-based loci; LDLR, GYPA, HBGG, D7S8, GC and HLA-DQA1 in central Pyrenees and Teruel (Spain). Journal of forensic sciences 11 9144942
1996 Evaluation of 7 DNA markers (D1S80, HLA-DQ alpha, LDLR, GYPA, HBGG, D7S8 and GC) in a Japanese population. International journal of legal medicine 11 8876324
2000 Endonuclease and helicase activities of bacteriophage lambda terminase: changing nearby residue 515 restores activity to the gpA K497D mutant enzyme. Virology 10 11062051
1996 Population data on the loci LDLR, GYPA, HBGG, D7S8, and GC in three southwest European populations. Journal of forensic sciences 10 8871390
2017 Validation of the Disease-Specific GPA for Patients With 1 to 3 Synchronous Brain Metastases in Newly Diagnosed NSCLC. Clinical lung cancer 9 28739316
2016 Discovery of new nanomolar inhibitors of GPa: Extension of 2-oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors. European journal of medicinal chemistry 9 28076824
2005 Melting curve and high-pressure chemistry of formic acid to 8 GPa and 600 K. The journal of physical chemistry. B 9 16853512
1996 Cardiac phosphocreatine deficiency induced by GPA during postnatal development in rat. Molecular and cellular biochemistry 9 8974041
2021 CD8+ T Cells in GCA and GPA: Bystanders or Active Contributors? Frontiers in immunology 8 33815414
2021 Internal resistive heating of non-metallic samples to 3000 K and >60 GPa in the diamond anvil cell. The Review of scientific instruments 8 34243587
2015 Anvil cell gasket design for high pressure nuclear magnetic resonance experiments beyond 30 GPa. The Review of scientific instruments 8 26724046
2014 High-pressure Raman scattering of CaWO₄ up to 46.3 GPa: evidence of a new high-pressure phase. Inorganic chemistry 8 25162383
1997 Japanese population DNA typing data for the loci LDLR, GYPA, HBGG, D7S8, and GC. Journal of forensic sciences 8 9304841
2020 The HXD95: a modified Bassett-type hydrothermal diamond-anvil cell for in situ XRD experiments up to 5 GPa and 1300 K. Journal of synchrotron radiation 7 32153294
2015 CD235a (Glycophorin-A) Is the Most Predictive Value Among Different Circulating Cellular Microparticles in Thrombocytopenic Human Immunodeficiency Virus Type 1. Journal of clinical laboratory analysis 7 25716234
2014 MN typing discrepancies based on GYPA-B-A hybrid. Vox sanguinis 7 24916810
2014 Intermolecular stabilization of 3,3'-diamino-4,4'-azoxyfurazan (DAAF) compressed to 20 GPa. The journal of physical chemistry. A 7 25011055
2013 X-ray absorption spectroscopy of GeO2 glass to 64 GPa. Journal of physics. Condensed matter : an Institute of Physics journal 7 24285424
2012 Thermodynamic properties of aqueous sodium sulfate solutions to 773 K and 3 GPa derived from acoustic velocity measurements in the diamond anvil cell. The Journal of chemical physics 7 23249011
2005 The GPA in vivo somatic mutation assay. Methods in molecular biology (Clifton, N.J.) 7 15502223

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