Affinage

SLC39A7

Zinc transporter SLC39A7 · UniProt Q92504

Length
469 aa
Mass
50.1 kDa
Annotated
2026-04-28
42 papers in source corpus 23 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC39A7 (ZIP7) is an ER-resident zinc transporter that gates the release of Zn²⁺ from ER/Golgi stores into the cytosol, functioning as a central node linking intracellular zinc homeostasis to cell signaling, ER proteostasis, and cell fate decisions. CK2-mediated phosphorylation at conserved serine residues (S275, S276, and two additional sites) activates ZIP7, triggering a cytosolic zinc wave that inhibits phosphatases and thereby potentiates tyrosine kinase, MAPK, PI3K-AKT, and mTOR signaling (PMID:22317921, PMID:28205653, PMID:18583420). Loss of ZIP7 causes ER zinc accumulation, protein disulfide isomerase aggregation, ER stress, impaired ERAD—partly through reduced Zn²⁺ supply to the Rpn11 proteasomal deubiquitinase—and defective secretory pathway trafficking of Notch and death receptors (PMID:28545780, PMID:38670102, PMID:23785054, PMID:30237509). Hypomorphic SLC39A7 mutations in humans cause a block in early B cell development due to insufficient cytosolic zinc and excessive phosphatase activity that attenuates pre-BCR/BCR signaling (PMID:30918914).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2005 High

    Establishing that ZIP7 is a zinc transporter operating in the secretory compartment resolved the question of how zinc stored in the Golgi/ER can be mobilized to the cytoplasm.

    Evidence V5-tagged ZIP7 expression in CHO cells and yeast Δzrt3 complementation with subcellular fractionation

    PMID:15705588

    Open questions at the time
    • Precise ER vs. Golgi localization was debated
    • Mechanism of transport gating was unknown
    • Physiological contexts requiring ZIP7 were uncharacterized
  2. 2008 High

    Demonstrating that ZIP7-released zinc inhibits phosphatases to activate receptor tyrosine kinases established the first signaling paradigm downstream of ZIP7-mediated zinc flux.

    Evidence siRNA knockdown in tamoxifen-resistant breast cancer cells with phosphatase activity and RTK phosphorylation readouts

    PMID:18583420

    Open questions at the time
    • Identity of the kinase activating ZIP7 was unknown
    • Whether ZIP7 activation was constitutive or regulated was unclear
  3. 2012 High

    Identification of CK2 as the activating kinase and the ER as the primary ZIP7 compartment revealed that ZIP7 operates as a gated channel whose phosphorylation triggers a zinc signaling wave activating AKT and ERK1/2.

    Evidence CK2 pharmacological inhibition, proximity ligation assay, and ZIP7 phosphosite mutagenesis in mammalian cells; confirmed in zebrafish morpholino knockdown with zinc rescue

    PMID:22317921 PMID:22912764

    Open questions at the time
    • Number and hierarchy of phosphorylation sites was incomplete
    • Structural basis of gating was unknown
  4. 2013 High

    Loss-of-function studies in Drosophila Catsup revealed that ZIP7-mediated zinc transport is required for Notch receptor trafficking through the ER/Golgi, linking ZIP7 to secretory pathway fidelity.

    Evidence Forward genetic screen in Drosophila with Notch localization and ER stress marker analysis

    PMID:23785054

    Open questions at the time
    • Whether the trafficking defect is zinc-specific or secondary to ER stress was not resolved
    • Mammalian Notch trafficking dependence on ZIP7 was not yet shown
  5. 2017 High

    Mapping four serine phosphorylation sites as collectively required for maximal ZIP7 activation, and demonstrating that ZIP7 loss causes ER zinc accumulation that aggregates PDI, provided the molecular mechanism by which ZIP7 maintains ER proteostasis.

    Evidence Combinatorial phosphosite mutagenesis with phospho-protein arrays; conditional KO mouse with PDI activity assays and ER zinc measurement; CK2α siRNA in cardiomyocytes with FRET zinc sensors

    PMID:28205653 PMID:28232492 PMID:28545780

    Open questions at the time
    • Structural model of ZIP7 gating was lacking
    • Direct measurement of zinc flux rate was not performed
  6. 2018 High

    Genetic ablation and unbiased screens established that ZIP7 zinc transport is causally required for cell proliferation, ER homeostasis, and surface trafficking of TNFR1/FAS death receptors, broadening ZIP7's role beyond kinase signaling to include receptor trafficking and necroptosis regulation.

    Evidence KO with zinc rescue in mammalian cells; genome-wide gene-trap and CRISPR screens in FADD-deficient haploid cells with death receptor surface-level measurement

    PMID:29980658 PMID:30237509

    Open questions at the time
    • Whether all ER-resident transmembrane proteins are equally affected by ZIP7 loss was untested
    • Selectivity of trafficking impairment was unclear
  7. 2019 High

    Discovery that hypomorphic SLC39A7 mutations in humans block B cell development—recapitulated by CRISPR mouse models—established ZIP7 as essential for B cell receptor signaling strength via cytosolic zinc modulation of phosphatase activity, and defined a human Mendelian immunodeficiency.

    Evidence Human autosomal recessive mutations, CRISPR-Cas9 mouse modeling, cytoplasmic zinc measurement, phosphatase activity assay, B cell development flow cytometry

    PMID:30718914

    Open questions at the time
    • Whether other immune lineages are similarly affected was not fully characterized
    • Precise phosphatase targets regulated by ZIP7-derived zinc were not identified
  8. 2019 High

    A direct-binding small-molecule inhibitor (NVS-ZP7-4) of ZIP7 confirmed its druggability and its requirement for Notch signaling in mammalian cells, validated by a resistance mutation (V430E).

    Evidence Phenotypic screen with photoaffinity labeling and resistance mutation sequencing in human cells

    PMID:30643281

    Open questions at the time
    • Binding site and inhibitor mechanism of action at atomic resolution were not determined
    • In vivo pharmacology not reported
  9. 2021 High

    A genome-wide RNAi screen identified ZIP7 as a genetic determinant of ferroptosis susceptibility, showing that ZIP7 inhibition triggers ER stress that induces HERPUD1, which in turn protects against ferroptosis.

    Evidence Genome-wide RNAi screen, ZIP7 siRNA/chemical inhibition, epistasis with HERPUD1 knockdown, ferroptosis assays

    PMID:33608508

    Open questions at the time
    • Whether ZIP7's role in ferroptosis is entirely ER-stress dependent or also involves direct lipid peroxidation modulation was not resolved
  10. 2024 High

    ZIP7-supplied Zn²⁺ was shown to activate the Rpn11 metalloproteinase in the proteasome lid, mechanistically coupling ER zinc release to ERAD substrate deubiquitination and explaining how ZIP7 overexpression rescues neurodegeneration from misfolded proteins.

    Evidence Drosophila border cell genetics and misfolded-rhodopsin neurodegeneration model; Rpn11 deubiquitinase activity assay in human cells

    PMID:38670102

    Open questions at the time
    • Whether Rpn11 is the sole proteasomal zinc-dependent target of ZIP7 is unknown
    • Quantitative contribution of ZIP7 vs. other zinc sources to proteasomal function not determined
  11. 2024 High

    Cardiac-specific ZIP7 knockout in diabetic mice prevented mitochondrial zinc depletion, restored PINK1/Parkin-dependent mitophagy, and rescued diabetic cardiomyopathy, establishing ZIP7 as a regulator of mitophagy via mitochondrial zinc levels.

    Evidence Cardiac-specific CRISPR/Cas9 conditional KO in T2DM mice, mitoKeima/mitoQC mitophagy assays, echocardiography

    PMID:39511569

    Open questions at the time
    • Whether ZIP7 directly transports zinc across the mitochondrial membrane or acts indirectly through ER-mitochondria contact sites is unresolved
    • The mechanism by which mitochondrial zinc levels regulate PINK1 stability was not defined
  12. 2025 Medium

    METTL9-mediated N1-histidine methylation at His45 and His49 of ZIP7 was identified as a post-translational modification that modulates ferroptosis via the PERK/ATF4/SLC7A11 axis and glutathione synthesis, adding a second regulatory layer beyond CK2 phosphorylation.

    Evidence METTL9 overexpression/knockdown with methylation site identification, SLC7A11 and glutathione measurement, adipogenic differentiation assay in vitro and OVX mouse model

    PMID:40414869

    Open questions at the time
    • Whether histidine methylation affects ZIP7 transport activity directly or indirectly is unknown
    • Independent validation of the methylation sites is needed
    • Interplay between CK2 phosphorylation and METTL9 methylation has not been tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic structure of ZIP7 and the gating mechanism, the full spectrum of zinc-dependent ER chaperones affected by ZIP7 loss, whether ZIP7 directly resides on mitochondrial membranes or acts through ER-mitochondria contact sites, and the identity of the specific phosphatases inhibited by ZIP7-released zinc.
  • No high-resolution structure of ZIP7 exists
  • Direct mitochondrial localization vs. MAM-mediated action is unresolved
  • Specific phosphatase substrates of ZIP7-derived zinc remain unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 8
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005739 mitochondrion 3 GO:0005794 Golgi apparatus 2
Pathway
R-HSA-382551 Transport of small molecules 6 R-HSA-162582 Signal Transduction 5 R-HSA-8953897 Cellular responses to stimuli 5 R-HSA-392499 Metabolism of proteins 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-9612973 Autophagy 2 R-HSA-168256 Immune System 1
Partners
ACSL4CSNK2A1MAZMETTL9NLRX1VDAC3

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 ZIP7 (SLC39A7) localizes to the Golgi apparatus and functions as a zinc transporter that moves zinc from the Golgi apparatus into the cytoplasm. Protein expression is repressed under zinc-rich conditions, but intracellular localization is unaffected by zinc status. V5-tagged fusion protein expression in CHO cells, yeast complementation assay (Δzrt3 mutant), subcellular fractionation, zinc measurement The Journal of biological chemistry High 15705588
2008 ZIP7 is required for redistribution of zinc from intracellular stores to the cytoplasm; siRNA-mediated knockdown of ZIP7 reduces intracellular zinc levels and abolishes zinc-induced inhibition of phosphatases, thereby blocking activation of EGFR, IGF-IR, Src, HER2, HER3, and HER4 in tamoxifen-resistant breast cancer cells. siRNA knockdown, growth factor receptor phosphorylation assays, zinc measurement Endocrinology High 18583420
2012 Protein kinase CK2 phosphorylates evolutionarily conserved residues on the endoplasmic reticulum zinc channel ZIP7, triggering gated release of Zn2+ from ER stores into the cytosol, which activates tyrosine kinases and downstream phosphorylation of AKT and ERK1/2. Pharmacological inhibition of CK2, proximity ligation assay (PLA), site-directed mutagenesis of ZIP7 phosphorylation sites, phospho-western blotting Science signaling High 22317921
2012 Zip7 is required for zinc homeostasis in vivo; morpholino knockdown in zebrafish causes reduced zinc in brain, eyes, and gills, and developmental defects (reduced head size, smaller eyes, shorter palate, curved spine) that are rescued by zinc supplementation. Morpholino antisense knockdown in zebrafish, synchrotron radiation X-ray fluorescence (SR-XRF) zinc quantification, zinc rescue experiment PloS one High 22912764
2013 Loss of Catsup (Drosophila ortholog of ZIP7/SLC39A7) causes Notch receptor accumulation in the ER and Golgi, impairs Notch signaling, and elevates ER stress, indicating ZIP7-mediated zinc transport is required for proper trafficking of the Notch receptor through the secretory pathway. Forward genetic screen, loss-of-function mutations, immunofluorescence imaging of Notch receptor localization, ER stress markers Development (Cambridge, England) High 23785054
2013 Zip7 knockdown in skeletal muscle cells reduces expression of glucose metabolism genes (including Glut4, Insr, Irs1, Irs2) and decreases insulin-stimulated glycogen synthesis and Akt phosphorylation, placing Zip7 as a regulator of glucose metabolism and insulin signaling in muscle. siRNA knockdown, qPCR, western blot, glycogen synthesis assay, Akt phosphorylation measurement PloS one Medium 24265765
2016 Intestinal epithelial-specific deletion of Zip7 triggers ER stress in proliferative progenitor cells, causes death of progenitor cells, loss of Olfm4+ intestinal stem cells, and degeneration of Paneth cells, demonstrating that ZIP7-mediated zinc transport from the ER is essential for intestinal epithelial homeostasis. Conditional knockout mouse (intestinal epithelium-specific), histology, ER stress markers, stem cell marker analysis (Olfm4) PLoS genetics High 27736879
2017 Phosphorylation of ZIP7 at four serine residues (including S275 and S276) is required for maximal activation and zinc release from intracellular stores, which drives MAPK, PI3K-AKT, and mTOR signaling pathways. Site-directed mutagenesis of individual and combined serine residues, phospho-protein arrays, downstream pathway analysis Metallomics : integrated biometal science High 28205653
2017 ZIP7 localizes to the ER in mesenchymal stem cells; ablation of Zip7 causes zinc accumulation in the ER, zinc-dependent aggregation and inhibition of protein disulfide isomerase (PDI), leading to ER dysfunction and impaired dermal development. Conditional knockout mouse (collagen 1-expressing tissue), immunofluorescence localization, zinc measurement, PDI activity assay, proliferation assay The Journal of investigative dermatology High 28545780
2017 Hyperglycemia increases ZIP7 expression and phosphorylation in cardiomyocytes, resulting in elevated cytosolic free Zn2+ and decreased ER/SR Zn2+; CK2α siRNA suppresses ZIP7 phosphorylation and the associated Zn2+ redistribution, confirming CK2 as the kinase responsible for ZIP7 activation in the heart. FRET-based zinc sensors, siRNA knockdown of CK2α, phospho-western blotting, subcellular fractionation in cardiomyocytes from diabetic rats Diabetes High 28232492
2018 Genetic ablation of SLC39A7 decreases cytosolic zinc levels, increases ER zinc levels, impairs cell proliferation, and induces ER stress; both ER stress and proliferation defects are rescued by increasing cytosolic zinc, confirming that ZIP7's zinc transport activity is causally responsible. Genetic knockout, zinc supplementation rescue, cell proliferation assay, ER stress markers, small-molecule screen Molecular pharmacology High 29980658
2018 SLC39A7 knockout in FADD-deficient haploid human cells confers resistance to necroptosis by impairing TNFR1 and FAS receptor surface trafficking; loss of SLC39A7 causes augmented ER stress that reduces receptor trafficking to the cell surface, globally affecting downstream death receptor signaling. Genome-wide gene-trap screen, CRISPR/Cas9 knockout, SLC-focused CRISPR screen, death receptor surface level measurement Cell death and differentiation High 30237509
2018 ZIP7 and ZnT7 also localize to mitochondria in cardiomyocytes; in hyperglycemic conditions, mitochondrial ZIP7 expression decreases while ZnT7 increases, leading to increased mitochondrial Zn2+, ROS production, and mitochondrial membrane potential changes, affecting SR-mitochondria coupling. Fluorescence imaging, mitochondrial fractionation/biochemical analysis, FRET-based zinc sensors Mitochondrion Medium 29307859
2019 ZIP7 (SLC39A7) governs Notch trafficking and signaling; a small-molecule inhibitor (NVS-ZP7-4) directly interacts with ZIP7 (photoaffinity labeling), and a V430E resistance mutation in ZIP7 confers resistance to the compound; inhibition alters ER zinc levels and induces ER stress-mediated apoptosis. Phenotypic screen, resistance mutation sequencing, photoaffinity labeling of ZIP7, zinc measurement in ER Nature chemical biology High 30643281
2019 Hypomorphic mutations of SLC39A7 in humans and CRISPR-modeled mice cause a block in B cell development; mutant B cells have diminished cytoplasmic free zinc, increased phosphatase activity, and decreased phosphorylation of pre-B cell and B cell receptor signaling molecules, establishing that cytosolic Zn2+ delivered by ZIP7 is required to modulate BCR signal strength. Human genetics (autosomal recessive mutations), CRISPR-Cas9 mouse modeling, cytoplasmic zinc measurement, phosphatase activity assay, phospho-western blotting, B cell development flow cytometry Nature immunology High 30718914
2019 ZIP7 is localized to the ER, while ZIP13 localizes to both ER and Golgi; ZIP7 depletion (but not ZIP13 depletion) induces ER stress in mesenchymal stem cells and inhibits fibrogenic differentiation, demonstrating distinct non-redundant roles for each transporter in dermal development. Sibling transporter comparison, immunofluorescence co-localization, ER stress markers, differentiation assays, genome-wide gene expression analysis International journal of molecular sciences Medium 31412620
2021 ZIP7 controls zinc transport from the ER to the cytosol and is a genetic determinant of ferroptosis; genetic or chemical inhibition of ZIP7 protects cells from ferroptosis by triggering ER stress (including induction of HERPUD1 and ATF3), and HERPUD1 knockdown abolishes this ferroptosis protection. Genome-wide RNAi screen, ZIP7 siRNA knockdown, chemical inhibition, zinc chelation/supplementation, epistasis with HERPUD1 knockdown, ferroptosis assays Cell death & disease High 33608508
2023 NLRX1 physically interacts with SLC39A7 (ZIP7) to form an NLRX1-SLC39A7 complex on the mitochondrial membrane of nucleus pulposus cells, modulating mitochondrial Zn2+ trafficking and thereby orchestrating mitochondrial dynamics (fission/fusion) and mitophagy. Co-immunoprecipitation (interaction), confocal co-localization on mitochondrial membrane, in vitro/in vivo cell and animal models, mitochondrial function assays Autophagy Medium 37876250
2024 ZIP7-mediated Zn2+ transport enhances ERAD by providing Zn2+ to the Rpn11 Zn2+ metalloproteinase in the proteasome lid, which is required for deubiquitination of substrates entering the proteasome; ZIP7 overexpression rescues neurodegeneration caused by misfolded rhodopsin in a Drosophila model. Drosophila border cell migration genetics, human cell ZIP7 manipulation, Rpn11 deubiquitinase activity assay, misfolded rhodopsin neurodegeneration model, proteasomal substrate deubiquitination assay Developmental cell High 38670102
2024 ZIP7 upregulation in T2DM mouse hearts reduces mitochondrial Zn2+, causing mitochondrial hyperpolarization and suppression of PINK1/Parkin-dependent mitophagy; cardiac-specific ZIP7 conditional knockout prevents these effects and rescues cardiac dysfunction and fibrosis in diabetic mice. Cardiac-specific CRISPR/Cas9 conditional knockout, echocardiography, mitoKeima/mitoQC mitophagy assays, ROS measurement, PINK1/Parkin mitochondrial accumulation assay Cardiovascular diabetology High 39511569
2025 METTL9 methylates SLC39A7 at His45 and His49 residues (N1-histidine methylation), which suppresses ferroptosis through the PERK/ATF4/SLC7A11 axis, promoting glutathione synthesis and reducing ROS; this modification inhibits adipogenic differentiation of mesenchymal stem cells. METTL9 overexpression/knockdown, N1-histidine methylation site identification (His45/His49), SLC7A11 and glutathione measurement, ROS assay, adipogenic differentiation assay in vitro and OVX mouse model in vivo Molecular medicine (Cambridge, Mass.) Medium 40414869
2026 ZIP7 interacts with MAZ in the cytoplasm to facilitate MAZ nuclear import; nuclear MAZ promotes MYBL2 transcription, driving prostate cancer bone metastasis; ZIP7 silencing inhibits cell migration, invasion, and bone metastasis in vivo. Co-immunoprecipitation, nuclear/cytoplasmic fractionation, RNA-seq, in vitro migration/invasion assays, intra-arterial bone metastasis xenograft model, ZIP7 inhibitor treatment Communications biology Medium 42010154
2024 ACSL4 interacts with both ZIP7 and VDAC3; this complex mediates ER-to-mitochondria iron transfer in hepatocytes under PFOS exposure, with ZIP7 functioning as an ER iron efflux channel and ACSL4 bridging ZIP7 and VDAC3 at the mitochondria-associated ER membrane. Co-immunoprecipitation (ZIP7-ACSL4-VDAC3), ZIP7 inhibition/siRNA knockdown, organellar iron measurement, VDAC3/MCU knockdown epistasis The Science of the total environment Medium 39579909

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Science signaling 222 22317921
2008 ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer Cells. Endocrinology 192 18583420
2005 The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. The Journal of biological chemistry 170 15705588
2009 Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends in molecular medicine 167 19246244
2021 Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell death & disease 99 33608508
2019 An essential role for the Zn2+ transporter ZIP7 in B cell development. Nature immunology 95 30718914
2016 Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress. PLoS genetics 77 27736879
2017 Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Diabetes 72 28232492
2017 Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling. Metallomics : integrated biometal science 71 28205653
2013 Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup. Development (Cambridge, England) 62 23785054
2017 Requirement of Zinc Transporter SLC39A7/ZIP7 for Dermal Development to Fine-Tune Endoplasmic Reticulum Function by Regulating Protein Disulfide Isomerase. The Journal of investigative dermatology 58 28545780
2013 The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells. PloS one 58 24265765
2019 Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nature chemical biology 57 30643281
2023 The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking. Autophagy 48 37876250
2018 Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Mitochondrion 40 29307859
2018 The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels. Molecular pharmacology 39 29980658
2012 Slc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish. PloS one 37 22912764
1996 cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. Genomics 34 8812499
2014 Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder. Acta neuropathologica communications 33 24581221
2019 miR-15a-3p Suppresses Prostate Cancer Cell Proliferation and Invasion by Targeting SLC39A7 Via Downregulating Wnt/β-Catenin Signaling Pathway. Cancer biotherapy & radiopharmaceuticals 28 31135177
2018 Zinc uptake promotes myoblast differentiation via Zip7 transporter and activation of Akt signalling transduction pathway. Scientific reports 28 30206294
2017 Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells. Acta biochimica et biophysica Sinica 28 28981607
2019 Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes. Nutrients 27 30781350
2018 Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell death and differentiation 27 30237509
2017 Knockdown of SLC39A7 suppresses cell proliferation, migration and invasion in cervical cancer. EXCLI journal 25 29285013
2019 Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer. Metallomics : integrated biometal science 21 31483418
2019 Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13 Are Essential for Dermal Development. International journal of molecular sciences 17 31412620
2018 The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidine-rich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum. Computers in biology and medicine 17 30029049
1996 Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and RT1.Hb genes in the rat major histocompatibility complex. Immunogenetics 17 8662089
2020 SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway. Bioscience reports 16 32109290
2019 The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet. Cells 16 31266232
2020 Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis. PloS one 14 32645059
2024 The Zn2+ transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila. Developmental cell 11 38670102
2024 ZIP7 contributes to the pathogenesis of diabetic cardiomyopathy by suppressing mitophagy in mouse hearts. Cardiovascular diabetology 11 39511569
2021 SLC39A7 promotes malignant behaviors in glioma via the TNF-α-mediated NF-κB signaling pathway. Journal of Cancer 7 34149917
2025 METTL9 mediated N1-Histidine methylation of SLC39A7 confers ferroptosis resistance and inhibits adipogenic differentiation in mesenchymal stem cells. Molecular medicine (Cambridge, Mass.) 5 40414869
2022 Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells. PloS one 4 35901031
2024 ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure. The Science of the total environment 3 39579909
2023 Rescue of proteotoxic stress and neurodegeneration by the Zn2+ transporter ZIP7. bioRxiv : the preprint server for biology 2 37292980
2009 Molecular characterization and association with carcass traits of the porcine SLC39A7 gene. Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 2 19630879
2026 Zinc-dependent Zip7-MAZ-MYBL2 axis promotes prostate cancer metastasis. Communications biology 0 42010154
2024 SLC39A7 upregulation links to skin fibrosis in systemic sclerosis via TGF-β/SMAD pathway. The Journal of dermatology 0 38217370