Affinage

SLC39A7

Zinc transporter SLC39A7 · UniProt Q92504

Length
469 aa
Mass
50.1 kDa
Annotated
2026-06-10
44 papers in source corpus 26 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC39A7/ZIP7 is an endoplasmic reticulum- and Golgi-resident zinc transporter that releases Zn2+ from intracellular stores into the cytosol, thereby converting compartmentalized zinc into a cytosolic signaling event that governs cell proliferation, secretory-pathway proteostasis, and growth-factor signaling (PMID:14525538, PMID:15705588, PMID:18583420). Gated zinc release is triggered by protein kinase CK2, which phosphorylates conserved serine residues (S275/S276 and additional sites) required for maximal ZIP7 activation; the resulting cytosolic zinc wave inhibits phosphatases and activates tyrosine kinases, AKT, ERK1/2, and the MAPK, mTOR, and PI3K/AKT pathways (PMID:22317921, PMID:28205653, PMID:28232492). Through this signaling output ZIP7 is required for growth-factor receptor activation in tamoxifen-resistant breast cancer cells, insulin signaling and glucose-gene expression in muscle, and B cell receptor signal strength, where hypomorphic human SLC39A7 mutations cause a block in B cell development and agammaglobulinemia replicated in CRISPR mouse models (PMID:18583420, PMID:24265765, PMID:30718914). A second, parallel role lies in maintaining ER zinc balance: loss of ZIP7 causes zinc to accumulate in the ER and depletes the cytosol, triggering ER stress, aggregation and inhibition of protein disulfide isomerase, and impaired proliferation that is rescued by restoring cytosolic zinc (PMID:28545780, PMID:29980658, PMID:27736879). ER-derived cytosolic zinc is also rate-limiting for ERAD, supplying Zn2+ to the proteasomal deubiquitinase Rpn11 to clear misfolded clients (PMID:38670102), and ZIP7-dependent ER homeostasis controls death-receptor trafficking and necroptosis via TNFR1/FAS surface levels and HERPUD1-dependent ferroptosis (PMID:30237509, PMID:33608508). ZIP7 additionally localizes to mitochondria where it shapes mitochondrial Zn2+ and PINK1/Parkin-dependent mitophagy (PMID:39511569). Across organisms ZIP7 is essential for developmental zinc homeostasis and secretory trafficking, including Notch receptor processing in Drosophila (PMID:22912764, PMID:23785054).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2004 Medium

    Established that ZIP7 is an intracellular-membrane protein that elevates cytosolic free zinc, defining it as a candidate store-release transporter rather than a plasma-membrane importer.

    Evidence Transient expression, Newport Green zinc dye, and immunolocalization in mammalian cells

    PMID:14525538

    Open questions at the time
    • Direction and driving force of transport not resolved
    • Metalloprotease-like motif function not tested
    • No identification of the store compartment beyond ER
  2. 2005 High

    Demonstrated that endogenous ZIP7 releases zinc from the Golgi/ER lumen into cytoplasm and nucleus, and that its expression is zinc-repressed, defining it as a regulated store-release transporter.

    Evidence Subcellular fractionation, immunolocalization in CHO cells, and yeast Δzrt3 complementation

    PMID:15705588

    Open questions at the time
    • Mechanism of activation/gating unknown
    • Transport stoichiometry not measured
  3. 2008 Medium

    Connected ZIP7-mediated zinc redistribution to downstream signaling by showing it is required for growth-factor receptor activation, framing zinc as a second messenger downstream of ZIP7.

    Evidence siRNA knockdown and phospho-western for EGFR/IGF-IR/Src/HER receptors in tamoxifen-resistant MCF7 cells

    PMID:18583420

    Open questions at the time
    • Phosphatase targets of cytosolic zinc not directly identified
    • Single cell-line context
  4. 2012 High

    Identified the activation mechanism: CK2 phosphorylation of conserved serines gates ER zinc release that activates tyrosine kinases, AKT, and ERK — converting ZIP7 from a passive transporter to a signal-gated channel.

    Evidence Proximity ligation, pharmacological CK2 inhibition, phospho-site mutagenesis, and zinc imaging; plus in vivo zebrafish morpholino knockdown with zinc rescue

    PMID:22317921 PMID:22912764

    Open questions at the time
    • Structural basis of phospho-gating unresolved
    • Whether CK2 acts directly on ZIP7 in all cell types not established
  5. 2013 Medium

    Extended ZIP7 function to secretory-pathway trafficking and tissue-specific signaling, linking ER zinc homeostasis to Notch receptor processing and to insulin/glucose signaling in muscle.

    Evidence Drosophila Catsup forward-genetic loss-of-function with Notch localization; siRNA knockdown with glycogen synthesis and phospho-AKT readouts in muscle cells

    PMID:23785054 PMID:24265765

    Open questions at the time
    • Direct mechanism linking ER zinc to receptor trafficking not defined
    • Glucose-gene regulation pathway not mapped
  6. 2017 High

    Defined the full phospho-site requirement and the pathway output, and revealed the ER zinc-PDI axis whereby ZIP7 loss causes ER zinc accumulation, PDI inhibition, and ER stress.

    Evidence Phospho-site mutagenesis with phospho-protein arrays; mesenchymal and intestinal conditional KO mice with PDI aggregation assays and ER stress markers; CK2α-dependent FRET zinc redistribution in cardiomyocytes

    PMID:27736879 PMID:28205653 PMID:28232492 PMID:28545780

    Open questions at the time
    • Quantitative contribution of each phospho-site unclear
    • How ER zinc excess inhibits PDI mechanistically beyond aggregation not fully detailed
  7. 2018 High

    Confirmed by genetic ablation that impaired ER-to-cytosol zinc transport is the causal driver of ER stress and proliferation defects, and broadened roles to myogenesis, death-receptor trafficking, and mitochondrial zinc.

    Evidence Gene ablation with zinc-rescue epistasis; siRNA in myoblasts; haploid gene-trap and CRISPR screens with surface receptor flow cytometry; cardiomyocyte fractionation showing mitochondrial localization

    PMID:29307859 PMID:29980658 PMID:30206294 PMID:30237509

    Open questions at the time
    • Mechanism of TNFR1/FAS trafficking dependence on ER zinc not resolved
    • Mitochondrial localization function not yet defined at this stage
  8. 2019 High

    Linked ZIP7 to human disease and provided a directly-binding chemical probe, establishing ZIP7 as a druggable target whose loss impairs BCR signaling via cytosolic zinc.

    Evidence Human autosomal-recessive genetics with CRISPR mouse modeling and phosphatase/phospho-BCR assays; phenotypic screen with V430E resistance mutation and photoaffinity labeling by NVS-ZP7-4; ZIP7/ZIP13 compartment-specific comparison

    PMID:30643281 PMID:30718914 PMID:31412620

    Open questions at the time
    • Structure of ZIP7 with bound inhibitor not determined
    • Phosphatase substrates of zinc in B cells not enumerated
  9. 2021 High

    Positioned ZIP7 upstream of HERPUD1 in a zinc/ER-stress axis controlling ferroptosis, identifying a defined genetic epistasis for ZIP7-dependent cell death sensitivity.

    Evidence Genome-wide RNAi screen, siRNA knockdown, zinc-rescue, and HERPUD1 knockdown epistasis in breast and renal cancer cells

    PMID:33608508

    Open questions at the time
    • How HERPUD1 induction executes ferroptosis downstream not detailed
    • Connection between ER zinc and lipid peroxidation unresolved
  10. 2023 Medium

    Identified mitochondrial protein complexes for ZIP7, implicating it in mitochondrial zinc and iron trafficking, dynamics, and mitophagy.

    Evidence Co-IP of NLRX1-SLC39A7 with mitophagy assays in nucleus pulposus cells; later ACSL4-ZIP7-VDAC3 Co-IP at ER-mitochondria contacts with organellar iron measurement

    PMID:37876250 PMID:39579909

    Open questions at the time
    • Co-IP complexes lack reciprocal/structural validation
    • Whether ZIP7 transports iron or only zinc at these sites not established
  11. 2024 High

    Defined a proteostasis output (ERAD via Rpn11 zinc supply) and additional mitophagy and metastasis roles, showing cytosolic zinc from ZIP7 is rate-limiting for deubiquitination.

    Evidence Drosophila genetics and proteasome deubiquitination assays with human cell zinc manipulation and in vivo rhodopsin rescue; cardiac-specific KO mouse with PINK1/Parkin and mitophagy flux assays; Co-IP/fractionation/RNA-seq for MAZ-MYBL2 in prostate metastasis

    PMID:38670102 PMID:39511569 PMID:42010154

    Open questions at the time
    • Direct demonstration that ZIP7 delivers Zn2+ to Rpn11 in human cells inferred from rate-limiting epistasis
    • Contradictory mitophagy effects across tissues not reconciled
  12. 2025 Medium

    Added a post-translational regulatory layer: METTL9-mediated histidine methylation of ZIP7 couples it to PERK/ATF4/SLC7A11 ferroptosis-resistance signaling.

    Evidence METTL9 methyltransferase assay, His45/His49 mapping, ferroptosis and PERK/ATF4/SLC7A11 readouts in vitro and OVX mouse model

    PMID:40414869

    Open questions at the time
    • Effect of His methylation on ZIP7 transport activity not measured
    • Single-lab finding without independent confirmation

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single ER/Golgi zinc transporter selectively partitions its cytosolic zinc output between phosphatase-inhibition signaling, ER proteostasis/ERAD, ferroptosis control, and mitochondrial dynamics across tissues remains unresolved.
  • No structure of human ZIP7 or its transport mechanism
  • Direct zinc substrates/targets of cytosolic phosphatases not enumerated
  • Tissue-specific opposing mitophagy roles not mechanistically reconciled

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005783 endoplasmic reticulum 6 GO:0005739 mitochondrion 4 GO:0005794 Golgi apparatus 3
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-8953897 Cellular responses to stimuli 4 R-HSA-5357801 Programmed Cell Death 2 R-HSA-9612973 Autophagy 2 R-HSA-392499 Metabolism of proteins 1
Partners
ACSL4CSNK2A1MAZMETTL9NLRX1VDAC3
Complex memberships
ACSL4-ZIP7-VDAC3 complexNLRX1-SLC39A7 complex

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 HKE4 (SLC39A7/ZIP7) localizes to intracellular membranes including the endoplasmic reticulum and increases intracellular free zinc in a time-, temperature-, and concentration-dependent manner, as measured by the zinc-specific fluorescent dye Newport Green. The protein contains a conserved HEXPHEXGD metalloprotease motif in transmembrane domain V and a consensus zinc-transport sequence in transmembrane domain IV. Transient expression in mammalian cells, fluorescent zinc dye (Newport Green), immunolocalization The Biochemical journal Medium 14525538
2005 Endogenous ZIP7 associates with the Golgi apparatus and transports zinc from the Golgi into the cytoplasm. In a yeast Δzrt3 mutant defective in vacuolar zinc release, ZIP7 expression decreased accumulated vacuolar zinc and increased nuclear/cytoplasmic labile zinc. ZIP7 protein expression is repressed under zinc-rich conditions but its intracellular localization is unaffected by zinc status. Subcellular fractionation, immunolocalization in CHO cells, yeast complementation assay (Δzrt3), V5-tagged overexpression The Journal of biological chemistry High 15705588
2008 ZIP7 knockdown (siRNA) in tamoxifen-resistant MCF7 (TamR) breast cancer cells reduces intracellular zinc levels and abolishes activation of EGFR, IGF-IR, Src, HER2, HER3, and HER4, demonstrating that ZIP7-mediated zinc redistribution from intracellular stores to the cytoplasm is required for zinc-induced phosphatase inhibition and downstream growth factor receptor activation. siRNA knockdown, western blot for receptor phosphorylation, intracellular zinc measurement Endocrinology Medium 18583420
2012 Protein kinase CK2 phosphorylates evolutionarily conserved residues in ZIP7 on the endoplasmic reticulum, triggering gated release of Zn2+ from ER stores into the cytosol, which activates tyrosine kinases and phosphorylation of AKT and ERK1/2. CK2 was identified as the responsible kinase by pharmacological inhibition, proximity ligation assay, and site-directed mutagenesis of the phosphorylation sites. Proximity ligation assay, pharmacological CK2 inhibition, site-directed mutagenesis, phospho-western blot, intracellular zinc imaging Science signaling High 22317921
2012 Morpholino-mediated knockdown of zip7 in zebrafish causes morphological defects (reduced head size, smaller eyes, shorter palates, curved spinal cord) accompanied by reduced zinc concentrations in brain, eyes, and gills as measured by synchrotron radiation X-ray fluorescence, and these defects are partially rescued by zinc supplementation, establishing an in vivo requirement for Zip7 in developmental zinc homeostasis. Morpholino antisense knockdown in zebrafish, synchrotron radiation X-ray fluorescence (SR-XRF), zinc rescue experiment PloS one Medium 22912764
2013 In Drosophila, loss of Catsup (the ZIP7 ortholog) causes Notch receptor to accumulate abnormally in the ER and Golgi, impairing Notch signaling, and elevates ER stress, linking ZIP7-dependent zinc homeostasis to secretory pathway protein trafficking and Notch receptor processing. Forward genetic screen, immunofluorescence localization of Notch in mutant epithelia, ER stress markers Development (Cambridge, England) Medium 23785054
2013 siRNA knockdown of Zip7 in skeletal muscle cells downregulates expression of glucose metabolism genes (including Glut4, Insr, Irs1, Irs2) and reduces insulin-stimulated glycogen synthesis and AKT phosphorylation, placing ZIP7 upstream of insulin signaling and glucose uptake in skeletal muscle. siRNA knockdown, RT-PCR, western blot, glycogen synthesis assay, phospho-AKT immunoblot PloS one Medium 24265765
2014 ZIP7 co-localizes with CLN6 (a disease-associated protein) at the ER/Golgi in neurons and astrocytes. Loss of Zip7 accompanies aberrant biometal accumulation in CLN6-variant NCL, and treatment with ZnII(atsm) upregulates Zip7, promotes zinc redistribution, and restores zinc-dependent functions in Cln6-deficient mouse neurons and astrocytes. Immunofluorescence co-localization, metal analysis, pharmacological rescue (ZnII(atsm)) in primary mouse neurons Acta neuropathologica communications Medium 24581221
2016 Intestinal epithelium-specific knockout of Zip7 in mice triggers ER stress in proliferative progenitor cells, causes cell death of progenitors, loss of Olfm4+ intestinal stem cells, and degeneration of Paneth cells, establishing ZIP7 as essential for intestinal epithelial homeostasis through maintenance of ER function. Conditional knockout mouse (intestinal epithelium-specific), histology, immunofluorescence, ER stress markers PLoS genetics High 27736879
2017 Site-directed mutagenesis of ZIP7 phosphorylation sites (S275, S276, and two additional predicted sites) demonstrates that all four residues are required for maximal ZIP7 activation and zinc release from intracellular stores. Phospho-protein arrays identify MAPK, mTOR, and PI3K-AKT as major downstream pathways activated by ZIP7-mediated zinc release. Site-directed mutagenesis, phospho-protein arrays, intracellular zinc imaging Metallomics : integrated biometal science High 28205653
2017 ZIP7 ablation in collagen 1-expressing mesenchymal stem cells causes dermal dysplasia in mice. Loss of ZIP7 causes zinc accumulation in the ER, leading to zinc-dependent aggregation and inhibition of protein disulfide isomerase (PDI), resulting in ER dysfunction and impaired cell proliferation. Conditional knockout mouse (mesenchymal), subcellular zinc measurement, PDI aggregation/activity assay, histology The Journal of investigative dermatology High 28545780
2017 In hyperglycemic cardiomyocytes, ZIP7 is phosphorylated (CK2α-dependent) and redistributes cytosolic free Zn2+ from the ER to the cytosol as shown by FRET-based Zn2+ sensors. siRNA silencing of CK2α suppresses this redistribution. ZIP7 and ZnT7 are also localized to the sarco(endo)plasmic reticulum in cardiomyocytes by fractionation. FRET-based Zn2+ sensors, siRNA knockdown of CK2α, subcellular fractionation, phospho-western blot Diabetes High 28232492
2018 Genetic ablation of SLC39A7 decreases cytosolic zinc, increases ER zinc levels, impairs cell proliferation, and induces ER stress. Increasing cytosolic zinc rescues both the ER stress and impaired proliferation, confirming impaired zinc transport as the causal mechanism. Genetic ablation (KO), intracellular zinc measurement, ER stress markers, proliferation assay, zinc supplementation rescue Molecular pharmacology High 29980658
2018 ZIP7 and ZnT7 are localized to both the sarco(endo)plasmic reticulum and mitochondria in cardiomyocytes, as confirmed by fluorescence imaging and biochemical fractionation. In hyperglycemic cells, ZIP7 is decreased and ZnT7 is increased in mitochondrial fractions, associated with elevated mitochondrial Zn2+, increased ROS, and altered S(E)R-mitochondria coupling proteins. Fluorescence microscopy, subcellular fractionation, western blot of mitochondrial fractions, ROS measurement Mitochondrion Medium 29307859
2018 Zinc promotes myoblast proliferation and differentiation via ZIP7-mediated activation of the PI3K/AKT pathway. siRNA depletion of ZIP7 reduces PI3K/AKT signaling and significantly reduces multinucleated myofibre and myotube formation. siRNA knockdown, western blot for pAKT, multinucleation assay Scientific reports Medium 30206294
2018 Loss-of-function genetic screens in haploid human KBM7 (FADD-deficient) cells identify SLC39A7 knockout as conferring necroptosis resistance by reducing TNFR1 surface levels. SLC-focused CRISPR screens show specificity for TNFR1- and FAS-mediated but not TRAIL-R1-mediated pathways. Mechanistically, SLC39A7 loss augments ER stress and impairs receptor trafficking. Genome-wide gene-trap screens, CRISPR/Cas9 KO, flow cytometry for surface receptor levels, cell death assays Cell death and differentiation High 30237509
2019 Hypomorphic mutations in SLC39A7 in humans cause a block in B cell development resulting in absent B cells and agammaglobulinemia. CRISPR-Cas9 modeling in mice reproduced the B cell developmental block. B cells from mutant mice showed diminished cytoplasmic free zinc, increased phosphatase activity, and decreased phosphorylation of pre-B cell receptor and B cell receptor signaling molecules, establishing ZIP7 as a modulator of BCR signal strength via cytosolic Zn2+. Human genetics (autosomal recessive mutations), CRISPR-Cas9 mouse modeling, flow cytometry, phosphatase activity assay, phospho-western blot, intracellular zinc measurement Nature immunology High 30718914
2019 A phenotypic screen identified compounds that impair Notch trafficking and induce ER stress-mediated apoptosis via ZIP7. A compound-resistant cell line harbored a V430E mutation in ZIP7, conferring transferable resistance. An analog of the compound NVS-ZP7-4 photoaffinity-labeled ZIP7 in cells, indicating direct compound-ZIP7 interaction. NVS-ZP7-4 alters zinc levels in the ER. Phenotypic screen, drug-resistance mutation sequencing, photoaffinity labeling in cells, ER zinc measurement Nature chemical biology High 30643281
2019 ZIP7 localized on the ER is distinct from ZIP13 (which localizes to both ER and Golgi when co-expressed). ZIP7 depletion induces ER stress in mesenchymal stem cells inhibiting fibrogenic differentiation, whereas ZIP13 depletion does not induce ER stress, establishing non-redundant, compartment-specific roles for each transporter. Conditional co-expression, immunofluorescence localization, ER stress markers, differentiation assay International journal of molecular sciences Medium 31412620
2021 ZIP7 controls zinc transport from the ER to the cytosol and is required for ferroptosis in breast and renal cancer cells. Genetic or chemical inhibition of ZIP7 protects cells against ferroptosis; this protection is abolished by zinc supplementation. ZIP7 knockdown triggers ER stress including induction of HERPUD1 and ATF3, and knockdown of HERPUD1 abolishes the ferroptosis protection from ZIP7 inhibition, placing ZIP7 upstream of HERPUD1 in ferroptosis regulation. Genome-wide RNAi screen, siRNA knockdown, zinc supplementation rescue, ER stress marker induction, HERPUD1 knockdown epistasis Cell death & disease High 33608508
2023 NLRX1 physically interacts with SLC39A7 (ZIP7) and forms an NLRX1-SLC39A7 complex on the mitochondrial membrane of nucleus pulposus cells, modulating mitochondrial Zn2+ trafficking to orchestrate mitochondrial dynamics (DNM1L/DRP1, OPA1, OMA1) and mitophagy. Co-immunoprecipitation, mitochondrial fractionation, FRET/zinc sensors, mitophagy assays (mito-LC3II, mitoKeima), animal and in vitro models Autophagy Medium 37876250
2024 ZIP7 overexpression in Drosophila enhances ERAD by supplying Zn2+ to the Rpn11 Zn2+ metalloproteinase in the proteasome lid, facilitating deubiquitination of client proteins. In human cells, ZIP7 and cytosolic Zn2+ are rate-limiting for this deubiquitination step. ZIP7 overexpression in a Drosophila model of neurodegeneration (misfolded rhodopsin) degrades misfolded Rh1 and rescues photoreceptor viability and vision. Drosophila border cell migration genetics, proteasome deubiquitination assay, human cell Zn2+ manipulation, in vivo neurodegeneration model (rhodopsin misfolding) Developmental cell High 38670102
2024 In diabetic cardiomyopathy (T2DM mouse model), ZIP7 is upregulated and mediates suppression of mitophagy via inhibition of the PINK1/Parkin pathway. ZIP7 cardiac-specific knockout (CRISPR-generated) prevents mitochondrial Zn2+ reduction, mitochondrial hyperpolarization, impaired PINK1/Parkin accumulation, and restores mitophagy, preventing cardiac dysfunction and fibrosis. CRISPR/Cas9 cardiac-specific KO mouse, echocardiography, mito-LC3II/mitoKeima/mitoQC mitophagy assays, DHE/mitoB ROS detection, mitochondrial Zn2+ measurement Cardiovascular diabetology High 39511569
2024 ACSL4 interacts with ZIP7 and VDAC3 in mouse liver and human hepatocytes, forming a complex at ER-mitochondria contact sites. Inhibition of ZIP7 reduces mitochondrial iron overload while elevating ER iron, and inhibition of ACSL4 reduces the ZIP7-VDAC3 interaction, implicating an ACSL4-ZIP7-VDAC3 axis in ER-to-mitochondria iron transfer under PFOS exposure. Co-immunoprecipitation, siRNA/inhibitor knockdown of ZIP7/VDAC3/ACSL4, organellar iron measurement, mouse liver model The Science of the total environment Medium 39579909
2025 METTL9 methylates SLC39A7 at His45 and His49 residues (N1-histidine methylation), suppressing ferroptosis through the ER stress PERK/ATF4 pathway and downstream SLC7A11-mediated glutathione synthesis, and inhibiting adipogenic differentiation of mesenchymal stem cells. Methyltransferase assay (METTL9), site-specific methylation mapping (His45, His49), ferroptosis assay, ROS measurement, PERK/ATF4/SLC7A11 western blot, adipogenic differentiation assay in vitro and OVX mouse model Molecular medicine (Cambridge, Mass.) Medium 40414869
2024 ZIP7 interacts with the transcription factor MAZ in the cytoplasm and facilitates its nuclear import. Nuclear MAZ promotes MYBL2 transcription, driving prostate cancer bone metastasis. ZIP7 silencing inhibits PCa cell migration/invasion in vitro and bone metastasis in vivo. Co-immunoprecipitation, nuclear/cytoplasmic fractionation, RNA-seq, in vivo intra-arterial bone metastasis xenograft model, siRNA/inhibitor Communications biology Medium 42010154

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Science signaling 224 22317921
2008 ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer Cells. Endocrinology 194 18583420
2009 Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends in molecular medicine 172 19246244
2005 The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. The Journal of biological chemistry 171 15705588
2004 Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. The Biochemical journal 115 14525538
2021 Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell death & disease 106 33608508
2019 An essential role for the Zn2+ transporter ZIP7 in B cell development. Nature immunology 97 30718914
2016 Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress. PLoS genetics 79 27736879
2017 Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Diabetes 73 28232492
2017 Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling. Metallomics : integrated biometal science 71 28205653
2013 Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup. Development (Cambridge, England) 64 23785054
2017 Requirement of Zinc Transporter SLC39A7/ZIP7 for Dermal Development to Fine-Tune Endoplasmic Reticulum Function by Regulating Protein Disulfide Isomerase. The Journal of investigative dermatology 60 28545780
2019 Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nature chemical biology 59 30643281
2013 The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells. PloS one 59 24265765
2023 The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking. Autophagy 53 37876250
2018 Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Mitochondrion 40 29307859
2018 The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels. Molecular pharmacology 39 29980658
2012 Slc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish. PloS one 39 22912764
1996 cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. Genomics 34 8812499
2014 Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder. Acta neuropathologica communications 33 24581221
2018 Zinc uptake promotes myoblast differentiation via Zip7 transporter and activation of Akt signalling transduction pathway. Scientific reports 32 30206294
2019 Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes. Nutrients 29 30781350
2017 Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells. Acta biochimica et biophysica Sinica 29 28981607
2019 miR-15a-3p Suppresses Prostate Cancer Cell Proliferation and Invasion by Targeting SLC39A7 Via Downregulating Wnt/β-Catenin Signaling Pathway. Cancer biotherapy & radiopharmaceuticals 28 31135177
2018 Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell death and differentiation 27 30237509
2017 Knockdown of SLC39A7 suppresses cell proliferation, migration and invasion in cervical cancer. EXCLI journal 26 29285013
1997 Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. Genomics 26 9205114
2019 Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer. Metallomics : integrated biometal science 22 31483418
2018 The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidine-rich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum. Computers in biology and medicine 20 30029049
2019 The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet. Cells 18 31266232
2019 Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13 Are Essential for Dermal Development. International journal of molecular sciences 18 31412620
1996 Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and RT1.Hb genes in the rat major histocompatibility complex. Immunogenetics 17 8662089
2020 SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway. Bioscience reports 16 32109290
2024 ZIP7 contributes to the pathogenesis of diabetic cardiomyopathy by suppressing mitophagy in mouse hearts. Cardiovascular diabetology 15 39511569
2020 Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis. PloS one 14 32645059
2024 The Zn2+ transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila. Developmental cell 13 38670102
2025 METTL9 mediated N1-Histidine methylation of SLC39A7 confers ferroptosis resistance and inhibits adipogenic differentiation in mesenchymal stem cells. Molecular medicine (Cambridge, Mass.) 7 40414869
2021 SLC39A7 promotes malignant behaviors in glioma via the TNF-α-mediated NF-κB signaling pathway. Journal of Cancer 7 34149917
2024 ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure. The Science of the total environment 6 39579909
2022 Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells. PloS one 4 35901031
2023 Rescue of proteotoxic stress and neurodegeneration by the Zn2+ transporter ZIP7. bioRxiv : the preprint server for biology 2 37292980
2009 Molecular characterization and association with carcass traits of the porcine SLC39A7 gene. Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 2 19630879
2026 Zinc-dependent Zip7-MAZ-MYBL2 axis promotes prostate cancer metastasis. Communications biology 0 42010154
2024 SLC39A7 upregulation links to skin fibrosis in systemic sclerosis via TGF-β/SMAD pathway. The Journal of dermatology 0 38217370

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