Affinage

SLC30A6

Zinc transporter 6 · UniProt Q6NXT4

Length
461 aa
Mass
51.1 kDa
Annotated
2026-06-10
60 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC30A6 (ZnT6) is a cation diffusion facilitator-family zinc transporter that operates in the early secretory pathway to metalate and activate zinc-requiring enzymes, controlling diverse downstream processes from ectoenzyme function to pigmentation and N-glycan maturation (PMID:15994300, PMID:28028180, PMID:38762179). ZnT6 localizes to the trans-Golgi network and vesicular compartments and functions not as an independent transporter but obligately as a heterodimer with ZnT5, into which ZnT5 contributes the His-rich loop that provides zinc-binding activity while ZnT6 plays a structural role in complex formation (PMID:11997387, PMID:15994300, PMID:19759014); ZnT5 recruits ZnT6 to the Golgi to assemble this heterodimer, which acts in parallel with ZnT7 homodimers (PMID:32179649). The ZnT5/ZnT6 complex activates client enzymes through a two-step mechanism, first stabilizing the apo-enzyme as a separable function from zinc transport and then loading zinc to generate the active holo-enzyme—failure of zinc loading routes the client to proteasomal degradation (PMID:16636052, PMID:21402707). Through this activity the complex matures a broad set of zinc-dependent enzymes including tissue-nonspecific alkaline phosphatase, autotaxin, MMP9, carbonic anhydrase IX, sphingomyelin phosphodiesterase 1, TYRP1, and Golgi α-mannosidase II, thereby supporting ectoenzyme function, sphingolipid balance, melanin synthesis, and hybrid-to-complex N-glycan conversion (PMID:21402707, PMID:28028180, PMID:35294847, PMID:37072620, PMID:38762179). By regulating labile Zn2+ specifically in the medial Golgi, ZnT5/ZnT6 tunes the localization and client-retrieval activity of the chaperone ERp44 in secretory proteostasis (PMID:37160917). ZnT6 is post-translationally controlled by SUMO1-mediated SUMOylation at Lys-409, which reduces its stability; high zinc triggers MTF-1/SENP1-dependent deSUMOylation that is required for efficient Zn2+ export into the Golgi (PMID:39367979).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2002 Medium

    Established that ZnT6 is a zinc transporter that moves cytoplasmic zinc into the Golgi/vesicular compartment, defining its basic transport directionality and subcellular site of action.

    Evidence Yeast overexpression growth assays and immunofluorescence co-localization with TGN38 and transferrin receptor in NRK cells

    PMID:11997387

    Open questions at the time
    • Did not identify physiological cargo enzymes or partner proteins
    • Transport mechanism inferred from yeast phenotype rather than direct flux measurement
  2. 2005 High

    Resolved how ZnT6 acts by showing it functions as an obligate hetero-oligomer with ZnT5 (not as a homo-oligomer) to supply zinc for alkaline phosphatase activation, with ZnT7 forming a parallel independent complex.

    Evidence DT40 gene targeting, reciprocal co-immunoprecipitation, ALP activity assays and rescue, plus yeast genetic complementation against Msc2p/Zrg17p

    PMID:15961382 PMID:15994300

    Open questions at the time
    • Did not establish which subunit binds zinc versus provides structure
    • Mechanism of client enzyme activation not yet defined
  3. 2009 High

    Defined the molecular determinants of complex assembly, showing ZnT5 and ZnT6 form discrete heterodimers and that the ZnT5 C-terminal tail selects ZnT6 as partner, while ZnT6 transmembrane residues are not zinc-binding.

    Evidence Co-immunoprecipitation, mutagenesis and chimera studies in DT40 cells deficient in ZnT5/ZnT6/ZnT7

    PMID:19759014

    Open questions at the time
    • No high-resolution structure of the heterodimer
    • Stoichiometry and transport pore architecture unresolved
  4. 2011 High

    Separated the two mechanistic steps of client activation, demonstrating ZnT5/ZnT6 first stabilizes apo-enzyme independent of transport and then loads zinc to form active holo-enzyme.

    Evidence Gene disruption/re-expression in DT40 cells using a zinc-transport-incompetent ZnT5 mutant, ALP activity and zinc supplementation assays

    PMID:21402707

    Open questions at the time
    • Structural basis of the apo-enzyme stabilization step not defined
    • Whether all clients share identical two-step kinetics not established
  5. 2016 High

    Broadened the client repertoire and disease relevance by showing ZnT5/ZnT6 activates cancer-promoting ectoenzymes (autotaxin, MMP9, CAIX) and mapped the ZnT5 di-proline motif required for client maturation but not transport.

    Evidence DT40 gene-disruption mutants with activity and secretion assays across multiple ectoenzymes; site-directed PP-motif mutagenesis

    PMID:27303047 PMID:28028180

    Open questions at the time
    • Direct contribution of ZnT6 residues to client recognition not dissected
    • In vivo relevance to tumor biology not yet tested
  6. 2014 Medium

    Confirmed heterodimerization occurs in living cells with functional zinc transport, validating the complex beyond biochemical co-IP.

    Evidence Bimolecular fluorescence complementation in live cells with Zinquin zinc-probe functional readout

    PMID:24451381

    Open questions at the time
    • Single-lab visualization
    • Did not quantify transport stoichiometry or kinetics
  7. 2020 High

    Revealed spatial regulation of assembly—ZnT5 recruits ZnT6 to the Golgi—and confirmed the two-complex activation mechanism is conserved in human cells.

    Evidence Genetic disruption in human HAP1 cells, purified ALP zinc-metalation assays, ZIP knockdowns, confocal imaging

    PMID:32179649

    Open questions at the time
    • Signal driving ZnT6 recruitment not identified
    • Source of the zinc pool delivered to clients not fully mapped
  8. 2022 High

    Extended client scope to lysosomal sphingomyelin phosphodiesterase 1, linking ZnT5/ZnT6 to sphingolipid homeostasis and membrane integrity.

    Evidence DT40 gene disruption/re-expression, SMPD1 activity assays, lipidomics, electron microscopy

    PMID:35294847

    Open questions at the time
    • Whether SMPD1 follows the same two-step activation as TNAP not tested
    • Physiological consequence in mammalian tissue not assessed
  9. 2023 High

    Placed ZnT5/ZnT6 in spatial proteostasis control, showing it sets labile Zn2+ specifically in the medial Golgi to tune ERp44 trafficking and client retrieval, and demonstrated a role in pigmentation via TYRP1 zinc supply.

    Evidence Systematic ZnT knockdowns with super-resolution microscopy and Golgi-targeted Zn2+ probes; gene disruption in medaka and melanoma cells with pigmentation and TYRP1 assays

    PMID:37072620 PMID:37160917

    Open questions at the time
    • Molecular mechanism by which ERp44 senses medial-Golgi Zn2+ not fully resolved
    • Whether TYRP1 metalation uses the canonical two-step mechanism not directly shown
  10. 2024 High

    Added N-glycan maturation as a downstream output (Golgi α-mannosidase II activation) with in vivo tumor relevance, and identified SUMOylation as a post-translational switch on ZnT6 transport.

    Evidence Gene disruption in DT40 and MIA PaCa-2 cells with N-glycan profiling, GMII activity assays and xenografts; SUMOylation site mutagenesis and MTF-1/SENP1 pathway manipulation in fish hepatocytes

    PMID:38762179 PMID:39367979

    Open questions at the time
    • How SUMOylation at Lys-409 mechanically reduces stability not defined
    • Whether SUMO regulation operates in mammalian secretory clients beyond hepatocytes unknown
  11. 2025 Medium

    Reported a non-canonical context where ZnT6 overexpression drives mitochondrial localization and redistributes Zn2+ into mitochondria, triggering fission, depolarization, ROS, and autophagy-linked apoptosis in cardiomyocytes.

    Evidence Confocal and electron microscopy, mitochondrial membrane potential/ROS/ATP assays, DRP1 translocation and autophagy/apoptosis markers in ZnT6-overexpressing H9c2 cells

    PMID:38091184 PMID:40087209

    Open questions at the time
    • Mitochondrial localization observed only under overexpression, not endogenous conditions
    • Single cell-line system without in vivo confirmation
    • Mechanism of mitochondrial targeting unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of zinc translocation by the ZnT5/ZnT6 heterodimer and the molecular rules governing client enzyme selection remain unresolved.
  • No high-resolution structure of the heterodimer or its client-loading interface
  • How specific apo-enzymes are recognized and stabilized prior to metalation is undefined
  • Whether the mitochondrial/cardiomyocyte phenotypes reflect a physiological function or an overexpression artifact is unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0140096 catalytic activity, acting on a protein 3
Localization
GO:0005794 Golgi apparatus 3 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-1430728 Metabolism 2 R-HSA-5653656 Vesicle-mediated transport 1
Partners
SLC30A5
Complex memberships
ZnT5/ZnT6 heterodimer

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 ZnT6 (SLC30A6) localizes to the trans-Golgi network and vesicular compartments (overlapping with TGN38 and transferrin receptor) in normal rat kidney cells, and its intracellular distribution is regulated by zinc levels. Overexpression in wild-type yeast causes growth inhibition, consistent with a zinc transport function that moves cytoplasmic zinc into the Golgi/vesicular compartment. Overexpression in yeast growth assays, immunofluorescence co-localization with TGN38 and transferrin receptor in NRK cells The Journal of biological chemistry Medium 11997387
2005 ZnT5 and ZnT6 form hetero-oligomers (but not homo-oligomers with each other) that constitute one of two distinct zinc transport complexes in the secretory pathway required for activation of alkaline phosphatases; ZnT7 operates independently as homo-oligomers. The Ser-rich loop of ZnT6 is dispensable for the zinc-supplying function of the ZnT5/ZnT6 hetero-oligomer, suggesting the His-rich loop of ZnT5 provides zinc-binding activity, while ZnT6's loop may serve a structural role in hetero-oligomer formation. Gene targeting in chicken DT40 cells, co-immunoprecipitation, alkaline phosphatase activity assays, transgene re-expression rescue experiments The Journal of biological chemistry High 15994300
2005 ZnT5 and ZnT6, mammalian homologues of yeast Msc2p and Zrg17p respectively, functionally interact and form a heteromeric zinc transport complex in the secretory pathway, paralleling the Msc2p/Zrg17p ER zinc transport complex in Saccharomyces cerevisiae. Co-immunoprecipitation, yeast genetic complementation, functional interaction assays The Journal of biological chemistry Medium 15961382
2006 ZnT5/ZnT6 hetero-oligomeric complexes in the secretory pathway are required for zinc loading of alkaline phosphatase; in ZnT5−/ZnT7−/− cells, inactive alkaline phosphatase is degraded via proteasome-mediated degradation without trafficking to the plasma membrane, revealing that zinc loading prevents proteasomal degradation of the enzyme. DT40 gene-targeting knockouts, ALP activity assays, proteasome inhibitor experiments, unfolded protein response assays The Journal of biological chemistry High 16636052
2009 ZnT5 and ZnT6 form heterodimers (not larger complexes) in the early secretory pathway. Mutagenesis showed that the conserved hydrophilic residues in transmembrane domains II and V of ZnT6 are not involved in zinc binding (unlike in homo-oligomeric CDF members). The cytosolic C-terminal tail of ZnT5 determines ZnT6 as its heterodimerization partner. The long N-terminal half of ZnT5 is dispensable for functional interaction with ZnT6. Co-immunoprecipitation, mutagenesis, chimera studies in DT40 cells deficient in ZnT5/ZnT6/ZnT7 The Journal of biological chemistry High 19759014
2011 TNAP is activated via a two-step mechanism: first, ZnT5/ZnT6 heterodimers stabilize TNAP as an apo-form (protein stabilization step independent of zinc transport); second, ZNT complexes load zinc to convert apo-TNAP to holo-TNAP. Expression of ZnT5/ZnT6 heterodimers reconstituted with a zinc transport-incompetent ZnT5 mutant stabilized TNAP protein as an apo-form but failed to restore TNAP activity, demonstrating that protein stabilization and zinc loading are separable functions. Gene disruption/re-expression in DT40 cells, zinc transport-incompetent ZnT5 mutants, ALP activity assays, zinc supplementation experiments The Journal of biological chemistry High 21402707
2014 ZnT5 and ZnT6 form heterodimers in situ in live cells, as directly visualized by bimolecular fluorescence complementation (BiFC). The BiFC signal from ZnT5-YC and ZnT6-YN co-transfection confirmed heterodimerization with subcellular compartment-appropriate localization, and the dimerized complex was functionally active as assessed by Zinquin fluorescent zinc probe. Bimolecular fluorescence complementation (BiFC) in live cells, Zinquin zinc probe functional assay The Journal of biological chemistry Medium 24451381
2016 ZnT5/ZnT6 heterodimers and ZnT7 homodimers activate cancer-promoting zinc-requiring ectoenzymes—autotaxin (ATX), matrix metalloproteinase 9 (MMP9), and carbonic anhydrase IX (CAIX)—via zinc metalation in the early secretory pathway. MMP9 required both ZnT complexes for secretion as well as activation; CAIX was additionally activated by ZnT4 homodimers. ATX followed a similar two-step activation mechanism as TNAP but with different protein stability regulation. DT40 gene-disruption mutants, activity assays for ATX, MMP9, CAIX; secretion assays; transgene re-expression The Journal of biological chemistry High 28028180
2016 The di-proline (PP) motif in luminal loop 2 of ZnT5 is important for TNAP activation by ZnT5/ZnT6 heterodimers. PP-to-AA mutation in ZnT5 reduced TNAP activation by ~90% without significantly impairing zinc transport activity of ZnT7, indicating the PP-motif is involved in the TNAP maturation/stabilization process rather than zinc transport per se. Site-directed mutagenesis of ZnT5 PP motif, DT40 TKO cell rescue assays, ALP activity assays, apo-to-holo conversion assays The Biochemical journal High 27303047
2020 ZnT5 recruits ZnT6 to the Golgi apparatus to form the heterodimeric complex (ZnT5 recruits ZnT6), revealing a previously unrecognized spatial regulation of ZnT5/ZnT6 heterodimer formation. In human HAP1 cells lacking both ZnT5 and ZnT7, TNAP activation is impaired, confirming conservation of the two-complex activation mechanism in human cells. Genetic disruption of ZnT5 and ZnT7 in human HAP1 cells, purified ALP zinc metalation assays, ZIP transporter knockdowns, confocal imaging of heterodimer localization The Journal of biological chemistry High 32179649
2022 ZnT5/ZnT6 heterodimers and ZnT7 homodimers in the early secretory pathway are required for activation of sphingomyelin phosphodiesterase 1 (SMPD1), a zinc-dependent lysosomal enzyme. Loss of both ZNT complexes results in reduced ceramide:sphingomyelin ratio, accumulation of minor sphingomyelin species, and multilamellar body-like structures indicative of membrane accumulation. Gene disruption/re-expression in DT40 cells, SMPD1 activity assays, lipidomics (ceramide/sphingomyelin ratio), electron microscopy American journal of physiology. Cell physiology High 35294847
2023 ZnT5/ZnT6 complex regulates labile Zn2+ concentration specifically in the medial Golgi compartment (distinct from ZnT4 at distal Golgi and ZnT7 at proximal Golgi), and ZnT-mediated Zn2+ fluxes tune the localization, trafficking, and client-retrieval activity of the chaperone ERp44 in the early secretory pathway. Systematic ZnT knockdowns, super-resolution microscopy, quantitative Zn2+-probes targeted to specific Golgi subregions, time-course imaging of synchronized secretory protein traffic, ERp44 functional assays Nature communications High 37160917
2023 ZnT5/ZnT6 heterodimers are required for TYRP1 expression and function in pigmentation. Loss of ZNT5/ZNT6 (and ZNT7) results in hypopigmentation in medaka fish and human melanoma cells, accompanied by immature melanosomes and reduced melanin content, phenocopying TYRP1 dysfunction. TYRP1 requires zinc (not copper) as a cofactor supplied by ZNT5-ZNT6 and ZNT7, and this requirement is conserved in human, mouse, and chicken orthologs. Gene disruption in medaka fish and melanoma cells, pigmentation assays, melanosome imaging, TYRP1 expression and functional assays, zinc supplementation experiments Communications biology High 37072620
2024 ZnT5/ZnT6 heterodimers and ZNT7 homodimers supply Zn2+ to Golgi α-mannosidase II (GMII), activating it to catalyze the conversion of hybrid- to complex-type N-glycans. Loss of both ZNT complexes results in accumulation of hybrid-type glycans and reduction of complex-type glycans; GMII activity is substantially decreased while lysosomal mannosidase (LAMAN) activity is unaffected, indicating specificity. Loss of ZNT5/ZNT6 and ZNT7 also significantly reduces pancreatic cancer cell growth in nude mouse xenograft models. Gene disruption in DT40 and MIA PaCa-2 cells, N-glycan profiling, GMII activity assays, LAMAN activity assays, xenograft mouse tumor growth assays The Journal of biological chemistry High 38762179
2024 ZnT6 undergoes SUMO1-mediated SUMOylation at Lys-409, which reduces ZnT6 protein stability (but does not affect its Golgi localization). High zinc activates the MTF-1/SENP1 pathway, leading to SENP1-mediated deSUMOylation of ZnT6 at Lys-409. DeSUMOylation of ZnT6 is required for efficient Zn2+ export from the cytosol into the Golgi apparatus. High-zinc diet feeding, SUMOylation site identification by mutagenesis, MTF-1/SENP1 pathway manipulation, Golgi localization imaging, Zn2+ transport functional assays in fish hepatocytes Cellular and molecular life sciences : CMLS Medium 39367979
2015 Reduced SLC30A6 (ZnT6) mRNA and protein expression was found in mammary tissue from two women producing severely zinc-deficient milk. Novel splice variants of SLC30A6 transcript were detected. Reduced SLC30A6 levels may be secondary to reduced SLC30A5 expression, as the two proteins function as a heterodimer in zinc transport. RT-PCR, Western blot, DNA methylation analysis, splice variant detection in lymphoblasts and fibroblasts from affected mothers Genes & nutrition Low 26319140
2025 ZnT6 overexpression in H9c2 cardiomyocytes causes ZnT6 to localize to mitochondria, redistributing Zn2+ from cytosol into mitochondria. This leads to increased mitochondrial fission (elevated DRP1 translocation to mitochondria), mitochondrial membrane depolarization, excess ROS production, reduced ATP levels, autophagosome accumulation, and autophagy-induced apoptosis. Confocal imaging, biochemical assays (mitochondrial membrane potential, ROS, ATP), electron microscopy, DRP1 translocation assay, autophagy and apoptosis markers in ZnT6-overexpressing H9c2 cells Molecular and cellular biochemistry Medium 40087209
2023 ZnT6 overexpression in insulin-resistant H9c2 cardiomyoblasts causes mitochondrial localization of ZnT6, elevated intracellular free Zn2+, abnormal mitochondrial and sarcoplasmic reticulum morphology (irregular cristae, dilated cisternae), mitochondrial depolarization, increased DRP1 total protein, increased K-acetylation, trimethylation of histone H3K27, and monomethylation of H3K36 — epigenetic modifications similar to those induced by insulin resistance. Confocal microscopy, electron microscopy, Western blot for ZnT6, MFN2, DRP1, histone modifications, mitochondrial membrane potential assay in ZnT6-OE and IR H9c2 cells Biochemical genetics Medium 38091184

Source papers

Stage 0 corpus · 60 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Functional characterization of a novel mammalian zinc transporter, ZnT6. The Journal of biological chemistry 176 11997387
2005 Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. The Journal of biological chemistry 142 15994300
2011 Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Human molecular genetics 93 21558427
2009 Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway. The Journal of biological chemistry 91 19759014
2005 Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells. The Journal of biological chemistry 89 15961382
2010 Dietary zinc absorption: A play of Zips and ZnTs in the gut. IUBMB life 86 20120011
2014 The Alu-rich genomic architecture of SPAST predisposes to diverse and functionally distinct disease-associated CNV alleles. American journal of human genetics 83 25065914
2006 Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells. The Journal of biological chemistry 80 16636052
2006 Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 76 17101726
2008 Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Investigative ophthalmology & visual science 59 18326752
2011 Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway. The Journal of biological chemistry 58 21402707
2016 Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review. Advances in nutrition (Bethesda, Md.) 56 27422508
2008 Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain. Neurobiology of aging 53 18378045
2011 Alu-specific microhomology-mediated deletion of the final exon of SPAST in three unrelated subjects with hereditary spastic paraplegia. Genetics in medicine : official journal of the American College of Medical Genetics 51 21659953
2014 In situ dimerization of multiple wild type and mutant zinc transporters in live cells using bimolecular fluorescence complementation. The Journal of biological chemistry 48 24451381
2012 Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. Journal of Alzheimer's disease : JAD 47 22349685
2014 Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis. Journal of neuroscience research 44 25284286
2013 Oocyte-cumulus cell interactions regulate free intracellular zinc in mouse oocytes. Reproduction (Cambridge, England) 44 23404848
2016 Analysis of Zinc-Exporters Expression in Prostate Cancer. Scientific reports 42 27833104
2023 Zinc homeostasis governed by Golgi-resident ZnT family members regulates ERp44-mediated proteostasis at the ER-Golgi interface. Nature communications 38 37160917
2016 Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims. Journal of psychiatric research 38 27661418
2006 Elevated zinc transporter-6 in mild cognitive impairment, Alzheimer disease, and pick disease. Journal of neuropathology and experimental neurology 36 16772872
2005 Abundant expression of zinc transporters in Bergman glia of mouse cerebellum. Brain research bulletin 32 15607832
2016 Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters. The Journal of biological chemistry 31 28028180
2013 Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway. PloS one 31 24204829
2016 Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. Frontiers in neuroscience 26 27147951
2008 Expression of the ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. Journal of molecular histology 25 18548323
2023 Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins. Communications biology 23 37072620
2021 Investigating the Short-Term Effects of Cold Stress on Metabolite Responses and Metabolic Pathways in Inner-Mongolia Sanhe Cattle. Animals : an open access journal from MDPI 22 34573458
2020 Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation. The Journal of biological chemistry 22 32179649
2016 The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation. The Biochemical journal 21 27303047
2017 Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS). Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 19 29199035
2021 Slc39a4 in the small intestine predicts zinc absorption and utilization: a comprehensive analysis of zinc transporter expression in response to diets of varied zinc content in young mice. The Journal of nutritional biochemistry 18 34843931
2014 Functional consequences of the over-expression of TRPC6 channels in HEK cells: impact on the homeostasis of zinc. Metallomics : integrated biometal science 18 24733507
2016 The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression. Progress in neuro-psychopharmacology & biological psychiatry 17 27565434
2012 Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver. The British journal of nutrition 17 22571646
2022 Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1. American journal of physiology. Cell physiology 16 35294847
2015 Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes & nutrition 16 26319140
2007 Zinc transporter mRNA expression in the RWPE-1 human prostate epithelial cell line. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 16 18097638
2021 Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco. Biochimica et biophysica acta. Gene regulatory mechanisms 14 34116248
2016 Nrf2-ARE-Dependent Alterations in Zinc Transporter mRNA Expression in HepG2 Cells. PloS one 14 27812191
2009 Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histology and histopathology 12 19283665
2022 The correlation and role analysis of SLC30A1 and SLC30A10 in cervical carcinoma. Journal of Cancer 10 35154468
2017 Interrelationships among mediators of cellular zinc homeostasis in healthy and type 2 diabetes mellitus populations. Molecular nutrition & food research 9 27957812
2024 ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II. The Journal of biological chemistry 8 38762179
2023 Nanoselenium Alleviates Cadmium-Induced Cerebral Injury via Regulating Cerebral Metal Transporters and Metal-Regulatory Transcription Factor 1. Journal of agricultural and food chemistry 7 37306234
2025 Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain. Nature communications 5 39934103
2024 Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacological reports : PR 5 39623245
2016 Long-term expression of zinc transporters in hippocampus following penicillin-induced developmental seizures and its regulation by E-64d. Experimental and therapeutic medicine 5 27347040
2025 ZnT6-mediated Zn2+ redistribution: impact on mitochondrial fission and autophagy in H9c2 cells. Molecular and cellular biochemistry 4 40087209
2023 Zinc pre-exposure improves Zn resistance by demethylation of metallothionein 2 and transcription regulation of zinc-regulatory genes in zebrafish ZF4 cells. Aquatic toxicology (Amsterdam, Netherlands) 4 37352751
2013 Large deletion mutation of SPAST in a multi-generation family from Sardinia. European journal of neurology 4 24824741
2025 A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for erectile dysfunction. Andrology 3 40145662
2024 Zinc transporter ZnT5 is associated with epithelial mesenchymal transition via SMAD1 in breast cancer. International journal of experimental pathology 3 39138630
2024 SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus. Cellular and molecular life sciences : CMLS 3 39367979
2023 An Overexpression of SLC30A6 Gene Contributes to Cardiomyocyte Dysfunction via Affecting Mitochondria and Inducing Activations in K-Acetylation and Epigenetic Proteins. Biochemical genetics 3 38091184
2025 A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration. JOR spine 2 40922807
2025 The Solute Carrier Superfamily as Therapeutic Targets in Pancreatic Ductal Adenocarcinoma. Genes 1 40282424
2025 Organic Trace Mineral Source Enhances the Bioavailability, Health Status, and Gut Microbiota Community in White Shrimp (Penaeus vannamei). Biology 1 40427729
2025 Novel Insights From In Silico Analysis of Biallelic ALPL (c.1001G/A and c.571G/A) in Two Mennonite Families Leading to Hypophosphatasia. Cureus 0 41158885

Missed literature

Know a paper Affinage missed for SLC30A6? Flag it for the maintainers and the community.

No submissions yet.