Affinage

SLC2A8

Solute carrier family 2, facilitated glucose transporter member 8 · UniProt Q9NY64

Length
477 aa
Mass
50.8 kDa
Annotated
2026-04-28
59 papers in source corpus 25 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC2A8 (GLUT8) is a class III facilitative hexose transporter that mediates uptake of glucose, fructose, dehydroascorbic acid, and trehalose, and functions predominantly at intracellular late endosomal/lysosomal membranes rather than at the cell surface (PMID:10821868, PMID:23396969, PMID:27922102). Constitutive intracellular retention is governed by an N-terminal [DE]XXXL[LI] dileucine motif whose interaction with AP-2 (via the beta2-adaptin subunit) and AP-1 drives clathrin-dependent endocytosis and lysosomal targeting; mutation of the motif or depletion of AP-2 redirects GLUT8 to the plasma membrane (PMID:16262729, PMID:16723738, PMID:21067453). In mouse blastocysts, insulin stimulates GLUT8 translocation to the cell surface to increase glucose uptake, but in most other cell types—including adipocytes, neurons, and hepatocytes—no tested stimulus triggers surface redistribution (PMID:10860996, PMID:11513753, PMID:16109784). GLUT8-mediated hepatic fructose and trehalose transport links it to downstream metabolic regulation: GLUT8 deficiency protects against high-fructose diet–induced dyslipidemia through enhanced PPARγ abundance, augments fasting PPARα/FGF21 signaling, and abolishes trehalose-induced AMPK-dependent autophagy (PMID:24519932, PMID:24030250, PMID:29596655, PMID:27922102).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2000 High

    Establishing that GLUT8 is a bona fide facilitative glucose transporter resolved the question of whether this orphan SLC2 family member had intrinsic sugar transport activity.

    Evidence Reconstituted glucose transport and cytochalasin B binding in COS-7 cells; parallel Km determination (~2 mM) and dileucine motif identification in Xenopus oocytes

    PMID:10671487 PMID:10821868

    Open questions at the time
    • Substrate selectivity beyond glucose not yet characterized
    • Physiological site of action (intracellular vs. plasma membrane) unclear
  2. 2000 High

    Demonstrating insulin-stimulated GLUT8 translocation and glucose uptake in blastocysts established the first physiological context for GLUT8 function and raised the question of whether insulin-regulated trafficking was a general feature.

    Evidence Antisense knockdown, glucose uptake assay, and immunolocalization in mouse blastocysts

    PMID:10860996

    Open questions at the time
    • Mechanism of insulin-regulated translocation in blastocysts not defined
    • Whether this occurs in somatic tissues was untested
  3. 2001 High

    Systematic testing in adipocytes showed GLUT8 does not undergo insulin-stimulated surface translocation like GLUT4, establishing that stimulus-regulated trafficking is cell-type specific and that intracellular retention is the default state.

    Evidence HA-tagged GLUT8, dominant-negative dynamin, and dileucine mutagenesis in primary rat adipocytes

    PMID:11513753

    Open questions at the time
    • Why blastocysts but not adipocytes support translocation remained unexplained
    • Nature of the intracellular compartment not resolved
  4. 2004 High

    Identifying the [DE]XXXL[LI] motif as a late endosomal/lysosomal targeting signal—distinct from GLUT4's recycling endosome pathway—resolved the compartment identity and explained constitutive intracellular retention.

    Evidence Site-directed mutagenesis of the dileucine motif glutamate residue combined with immunofluorescence in 3T3-L1, HEK293, and CHO cells

    PMID:16262729

    Open questions at the time
    • Adaptor proteins mediating the sorting not yet identified
    • Functional role of lysosomal localization unknown
  5. 2005 Medium

    Comprehensive stimulus screens in neurons confirmed that no known signaling pathway induces GLUT8 surface translocation in neuronal cells, reinforcing its constitutive intracellular residence and distinguishing it mechanistically from GLUT4.

    Evidence Myc-tagged GLUT8 adenovirus in PC12 cells and primary hippocampal neurons tested with depolarization, PKA/PKC activators, tyrosine kinase signaling, glucose deprivation, AMPK activation, and osmotic shock

    PMID:16109784

    Open questions at the time
    • Subcellular compartment in neurons (partially ER-overlapping) differs from late endosome assignment in other cells
    • Functional role of neuronal GLUT8 unresolved
  6. 2006 High

    Identification of AP-2 beta2-adaptin as the direct binding partner for the GLUT8 dileucine motif defined the molecular mechanism of clathrin-mediated endocytosis that enforces intracellular retention.

    Evidence Yeast two-hybrid, GST pulldown, and AP-2 mu2 RNAi knockdown causing surface accumulation

    PMID:16723738

    Open questions at the time
    • Role of AP-1 interaction in biosynthetic trafficking not fully dissected
    • Whether AP-2-mediated endocytosis is regulated in any tissue not tested
  7. 2006 High

    Generation of Slc2a8-knockout mice showed the gene is dispensable for embryonic development and glucose homeostasis but revealed unexpected phenotypes—increased hippocampal neurogenesis and prolonged cardiac P-wave duration—pointing to specialized tissue functions.

    Evidence Slc2a8 knockout mice with BrdU incorporation in hippocampus and cardiac electrophysiology

    PMID:16705176

    Open questions at the time
    • Mechanistic basis for hippocampal proliferation and cardiac conduction phenotypes unknown
    • Metabolic challenge conditions not yet tested
  8. 2009 High

    Demonstrating that the GLUT8 N-terminal domain interacts with both AP-1 and AP-2 and is sufficient to redirect a heterologous reporter to intracellular membranes established the minimal sorting determinant and extended the adaptor interaction map.

    Evidence Chimeric IL-2Rα/GLUT8 constructs and AP complex interaction assays in spermatocytes/spermatids

    PMID:19523115

    Open questions at the time
    • Relative contributions of AP-1 versus AP-2 to steady-state localization not resolved
    • Functional role in spermatogenesis not defined
  9. 2010 Medium

    Fine-mapping the dileucine motif flanking residues showed that the proline at position −2 tunes AP-1/AP-2 binding affinity and is critical for lysosomal versus surface sorting, explaining differences between GLUT8 and GLUT12 trafficking.

    Evidence Systematic mutagenesis of XXX residues in [DE]XXXL[LI] motif with subcellular localization in CHO/HEK293 cells

    PMID:21067453

    Open questions at the time
    • Whether these residues are post-translationally modified to regulate sorting is unknown
    • In vivo relevance of motif variants not tested
  10. 2012 High

    Establishing GLUT8 as a hepatic fructose transporter and showing that its loss protects against fructose-induced lipogenesis and steatosis redefined GLUT8's primary physiological substrate in the liver as fructose rather than glucose.

    Evidence shRNA knockdown and adenoviral overexpression with radiolabeled fructose uptake in hepatocytes; GLUT8-KO mice on high-fructose diet

    PMID:24519932

    Open questions at the time
    • Intracellular compartment where fructose transport occurs not specified
    • Relationship to known fructolysis enzymes not explored
  11. 2012 High

    Finding that GLUT8 deficiency increases enterocyte fructose uptake (with compensatory GLUT12 upregulation) revealed tissue-specific directionality: GLUT8 restricts fructose absorption in the gut but promotes it in the liver.

    Evidence GLUT8 shRNA in Caco2 cells and GLUT8-KO mice with jejunal 14C-fructose uptake

    PMID:22822162

    Open questions at the time
    • Mechanism by which GLUT8 suppresses enterocyte fructose uptake (competition vs. regulation) unclear
    • Whether GLUT8 functions on the apical or intracellular membranes in enterocytes not resolved
  12. 2012 High

    Demonstrating that GLUT8 loss impairs oocyte ATP production and endometrial decidualization established a non-redundant metabolic role in female reproduction.

    Evidence Slc2a8 knockout mice with oocyte metabolic assays, ATP measurement, decidualization assay, and ovarian transplantation

    PMID:22649075

    Open questions at the time
    • Substrate transported in oocytes (glucose, fructose, or trehalose) not determined
    • Signaling link between GLUT8 and decidualization not identified
  13. 2013 High

    Kinetic characterization of dehydroascorbic acid transport expanded the substrate repertoire beyond hexoses, showing GLUT8 is a multi-substrate transporter.

    Evidence Xenopus oocyte reconstitution with radiolabeled DHA, kinetic analysis (Km 3.23 mM), competitive inhibition with glucose/fructose/flavonoids

    PMID:23396969

    Open questions at the time
    • Physiological relevance of DHA transport through a lysosomal transporter not established
    • Whether DHA and hexose transport use the same binding site not structurally resolved
  14. 2013 Medium

    Linking GLUT8 deficiency to enhanced hepatic PPARγ abundance and protection from fructose-induced metabolic syndrome positioned GLUT8 upstream of lipogenic transcriptional programs.

    Evidence GLUT8-KO mice on high-fructose diet and adenoviral GLUT8 overexpression suppressing PPARγ

    PMID:24030250

    Open questions at the time
    • Direct versus indirect regulation of PPARγ by GLUT8-mediated fructose flux not distinguished
    • Mechanism of PPARγ regulation not identified
  15. 2016 High

    Identifying GLUT8 as the mammalian trehalose transporter and showing that trehalose-induced AMPK activation and autophagy require GLUT8 provided a mechanistic explanation for how a lysosomal transporter connects sugar sensing to autophagic signaling.

    Evidence GC/MS, radiolabeled trehalose uptake, GLUT8-KO hepatocytes, rescue by Drosophila Tret1, AMPK phosphorylation and autophagy flux assays

    PMID:27922102

    Open questions at the time
    • Whether trehalose is transported into or out of the lysosome not resolved
    • Molecular link from trehalose to AMPK activation unknown
  16. 2018 Medium

    Epistasis experiments placing GLUT8 upstream of PPARα/FGF21 during fasting revealed that GLUT8 normally suppresses the fasting ketogenic response, integrating its lysosomal transport function with systemic metabolic adaptation.

    Evidence GLUT8-KO mice with fasting metabolic phenotyping; adenoviral PPARα knockdown normalizing enhanced ketogenesis and FGF21

    PMID:29596655

    Open questions at the time
    • Substrate whose lysosomal transport by GLUT8 controls PPARα activity not identified
    • Whether this operates through mTORC1 or another nutrient-sensing pathway unknown
  17. 2020 Medium

    Discovery of lysosome-dependent C-terminal cleavage of GLUT8 suggested it undergoes regulated proteolytic processing, potentially linking its lysosomal residence to TXNIP-mediated hexosamine sensing.

    Evidence Lysosomal inhibitor experiments, subcellular fractionation showing cleaved C-terminal peptide in a separate vesicle population

    PMID:33077497

    Open questions at the time
    • Protease responsible for cleavage not identified
    • Functional consequence of cleavage for transport activity unknown
    • TXNIP connection is correlative
  18. 2022 Medium

    Identification of TM4SF5 as a cell-surface binding partner that modulates GLUT8 plasma membrane availability for fructose uptake provided the first evidence of regulated GLUT8 surface translocation outside of blastocysts.

    Evidence Co-immunoprecipitation, Tm4sf5-KO mice, fructose-induced dissociation dynamics by immunofluorescence

    PMID:35123128

    Open questions at the time
    • Interaction validated by Co-IP only; reciprocal and endogenous validation limited
    • Whether TM4SF5-GLUT8 interaction is direct or via a complex not resolved
    • Tissue generality of this mechanism unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the directionality and physiological substrate of GLUT8's lysosomal transport in vivo, the structural basis of its multi-substrate recognition, how lysosomal GLUT8 activity is sensed by PPARα/PPARγ and AMPK signaling cascades, and the functional significance of its C-terminal cleavage.
  • No crystal or cryo-EM structure available
  • Directionality of lysosomal transport (import vs. export) not determined
  • Precise molecular link from GLUT8 activity to PPAR and AMPK signaling undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 6
Localization
GO:0005764 lysosome 3 GO:0005768 endosome 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-382551 Transport of small molecules 5 R-HSA-1430728 Metabolism 3 R-HSA-9612973 Autophagy 1
Partners
AP1AP2B1TM4SF5

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 GLUT8 (SLC2A8) is a facilitative glucose transporter with intrinsic glucose transport activity, demonstrated by specific cytochalasin B binding (Kd=56.6 nM) and reconstitutable glucose transport in COS-7 cells transfected with GLUT8 cDNA. Heterologous expression in COS-7 cells, cytochalasin B binding assay, reconstituted glucose transport assay The Journal of biological chemistry High 10821868
2000 GLUT8 mediates insulin-stimulated glucose uptake in mouse blastocysts; insulin induces a change in intracellular localization of GLUT8 that translates into increased glucose uptake, an effect blocked by antisense oligoprobes. Antisense oligoprobe inhibition, glucose uptake assay, immunolocalization in blastocysts Proceedings of the National Academy of Sciences of the United States of America High 10860996
2000 GLUTX1 (GLUT8) has glucose transport activity with Km ~2 mM when expressed in Xenopus oocytes, but only after mutational suppression of an N-terminal dileucine internalization motif that normally retains the protein intracellularly; transport is inhibited by cytochalasin B and partly competed by D-fructose and D-galactose. Xenopus oocyte expression, transport assay, site-directed mutagenesis of dileucine motif The Journal of biological chemistry High 10671487
2001 GLUT8 is retained in intracellular compartments via its N-terminal dileucine motif; mutation of this motif leads to constitutive plasma membrane expression, and blocking endocytosis with dominant-negative dynamin also causes cell surface accumulation, but unlike GLUT4, GLUT8 does not translocate to the plasma membrane in response to insulin, phorbol ester, or hyperosmolarity in rat adipose cells. HA-epitope tagging, transfection in primary rat adipocytes, dominant-negative dynamin co-expression, immunofluorescence The Biochemical journal High 11513753
2002 GLUT8 undergoes rapid translocation to the rough endoplasmic reticulum in rat hippocampal neurons following peripheral glucose administration, as shown by immunogold electron microscopy and subcellular fractionation; this trafficking is impaired in streptozotocin diabetic rats, suggesting insulin is required for GLUT8 translocation. Immunogold electron microscopy, subcellular membrane fractionation, immunoblot The Journal of comparative neurology Medium 12271485
2004 GLUT8 contains a [DE]XXXL[LI] late endosomal/lysosomal targeting motif; mutation of the glutamate to arginine (as in GLUT4) alters GLUT8 endocytosis and retains it at the plasma membrane; GLUT8 does not reside in a recycling vesicle pool and localizes to late endosomes/lysosomes. Site-directed mutagenesis, immunofluorescence, subcellular localization in 3T3L1, HEK293, CHO cells Traffic (Copenhagen, Denmark) High 16262729
2004 GLUT8 translocation to the plasma membrane in neuronal N2A cells is not stimulated by insulin, IGF-1, KCl depolarization, or hypoxia; mutation of the N-terminal dileucine motif (L12,13→A12,13) constitutively localizes GLUT8 to the plasma membrane. GLUT8-GFP stable transfection, immunohistochemistry, subcellular fractionation, site-directed mutagenesis Journal of neuroscience research Medium 14994344
2006 GLUT8 endocytosis is mediated by direct interaction of its N-terminal dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex, targeting GLUT8 to clathrin-coated vesicles; RNAi knockdown of AP-2 mu2 subunit causes GLUT8 accumulation at the plasma membrane comparable to dominant-negative dynamin. Yeast two-hybrid, GST pulldown, RNAi knockdown of AP-2, immunofluorescence Journal of cell science High 16723738
2006 Deletion of the Slc2a8 gene in mice results in increased hippocampal neuronal proliferation and increased P-wave duration in the heart, but does not impair normal embryonic or postnatal development or glucose homeostasis; GLUT8 is dispensable for embryonic development. Knockout mouse generation, cardiac electrophysiology, hippocampal BrdU incorporation assay Molecular and cellular biology High 16705176
2009 Endogenous GLUT8 in spermatocytes and spermatids localizes to a late endosomal/lysosomal compartment; its N-terminal intracellular domain interacts with AP1 and AP2 (but not AP3 or AP4), and the GLUT8 N-terminal intracellular domain fused to the tailless IL-2 receptor alpha chain is sufficient to direct that chimera to intracellular membranes. Immunofluorescence of endogenous protein, AP complex interaction assays, chimeric protein targeting experiments The FEBS journal High 19523115
2012 GLUT8 is required for hepatocyte fructose transport; GLUT8 overexpression or shRNA-mediated knockdown significantly increases or decreases radiolabeled fructose uptake in cultured hepatocytes; GLUT8-deficient mice show diminished fructose uptake, reduced de novo lipogenesis, and attenuated hepatic triglyceride/cholesterol accumulation on a high-fructose diet. shRNA knockdown, adenoviral overexpression, radiolabeled fructose uptake, GLUT8-deficient mouse model, hepatic lipid quantification The Journal of biological chemistry High 24519932
2012 GLUT8 regulates enterocyte fructose transport; shRNA-mediated GLUT8 knockdown in Caco2 cells stimulates fructose uptake; GLUT8-deficient mice exhibit greater jejunal fructose uptake and GLUT8 deficiency leads to compensatory upregulation of GLUT12 in enterocytes. shRNA knockdown in Caco2 cells, GLUT8-KO mouse model, 14C-fructose uptake assay, immunoblot Endocrinology High 22822162
2012 Slc2a8 deficiency in mice impairs oocyte metabolism and ATP production, and causes defective decidualization of endometrial stromal cells, leading to reduced litter size and impaired implantation; ovarian transplantation studies confirm effects on both embryo and implantation. Slc2a8 knockout mice, oocyte metabolic assays, ATP measurement, decidualization assay, ovarian transplantation Biology of reproduction High 22649075
2013 GLUT8 transports dehydroascorbic acid (DHA) in Xenopus oocytes with Km of 3.23 mM and Vmax of 10.1 pmol/min/oocyte; DHA transport by GLUT8 is inhibited by glucose, fructose, and flavonoids (phloretin, quercetin), and maximal transport rates for DHA are lower than for 2-deoxy-D-glucose or fructose. Xenopus oocyte expression system, radiolabeled DHA and glucose transport assays, competitive inhibition studies The Journal of biological chemistry High 23396969
2013 GLUT8 deficiency in male mice confers resistance to high-fructose diet-induced glucose intolerance and dyslipidemia, associated with enhanced hepatic PPARγ protein abundance; adenoviral GLUT8 overexpression in liver suppresses hepatic PPARγ expression, placing GLUT8 upstream of PPARγ in fructose-induced metabolic regulation. GLUT8-KO mice, high-fructose diet challenge, adenoviral overexpression, immunoblot for PPARγ Molecular endocrinology Medium 24030250
2016 SLC2A8 (GLUT8) is a mammalian trehalose transporter; trehalose enters hepatocytes via GLUT8 (demonstrated by GC/MS, fluorescence microscopy, and radiolabeled uptake); GLUT8-deficient hepatocytes and mice resist trehalose-induced AMPK phosphorylation and autophagic induction; heterologous overexpression of the Drosophila trehalose transporter Tret1 rescues autophagic flux in GLUT8-deficient hepatocytes. GC/MS, fluorescence microscopy, radiolabeled trehalose uptake, GLUT8-KO mouse/hepatocytes, Tret1 rescue experiment, AMPK phosphorylation immunoblot, autophagy flux assay Scientific reports High 27922102
2018 GLUT8 deficiency in mice enhances hepatic PPARα activity and FGF21 secretion during fasting; hepatic PPARα knockdown in GLUT8-deficient mice normalizes the enhanced ketogenic and FGF21 secretory responses, placing GLUT8 upstream of PPARα in the adaptive fasting response. GLUT8-KO mice, fasting metabolic phenotyping, adenoviral PPARα knockdown, FGF21 ELISA, mitochondrial respiratory function assays Endocrinology Medium 29596655
2020 GLUT8 undergoes a lysosome-dependent cleavage reaction that releases the carboxy-terminal peptide to a separate vesicle population; GLUT8 does not transport glucose to the cell surface but is localized at the late endosomal/lysosomal interface where it may function as a sensory component of TXNIP-mediated hexosamine homeostasis. Splice variant cataloging, lysosomal inhibitor experiments, subcellular fractionation, immunofluorescence Molecular and cellular biology Medium 33077497
2022 TM4SF5 binds GLUT8 at the cell surface and modulates its translocation to the plasma membrane; fructose treatment transiently decreases TM4SF5-GLUT8 binding, allowing GLUT8 to separate and become active for fructose uptake; Tm4sf5 suppression or knockout reduces fructose uptake, de novo lipogenesis, and steatosis. Co-immunoprecipitation, Tm4sf5-KO mice, in vitro fructose uptake assays, immunofluorescence of TM4SF5-GLUT8 interaction dynamics Molecular metabolism Medium 35123128
2005 GLUT8 in PC12 cells and primary hippocampal neurons localizes to a perinuclear compartment partially overlapping with ER markers but not trans-Golgi, early endosomes, lysosomes, or synaptic vesicles; no stimulus tested (depolarization, PKA/PKC activation, tyrosine kinase signaling, glucose deprivation, AMPK stimulation, osmotic shock) induces GLUT8 surface translocation, and no constitutive recycling through the plasma membrane was detected. Recombinant adenoviral GLUT8 with extracellular myc tag, immunofluorescence, dominant-negative dynamin co-expression, anti-myc antibody internalization assay Endocrinology Medium 16109784
2010 The proline at position -2 from the dileucine residues in the [DE]XXXL[LI] motif of GLUT8 influences the affinity of AP1 and AP2 for GLUT8 and is critical for intracellular sorting to lysosomes; replacing the XXX (TQP) residues in GLUT8 with those from GLUT12 (GPN) causes dramatic missorting of GLUT8 to the cell surface. Site-directed mutagenesis of dileucine motif flanking residues, immunofluorescence, subcellular localization in CHO/HEK293 cells Molecular membrane biology Medium 21067453
2024 SLC2A8 RNAi knockdown (79% mRNA reduction) in human first-trimester trophoblast ACH-3P cells reduces glucose uptake by 11% and differentially expresses genes involved in cellular respiration, oxidative phosphorylation, and ATP synthesis, suggesting GLUT8's primary function in trophoblasts is supporting cellular respiration rather than glucose supply. Lentiviral RNAi knockdown, glucose uptake assay, RNA-seq transcriptomics Cells Medium 38474355
2019 Endogenous GLUT8 partially co-localizes with cis-Golgi markers (58K protein, GM130) and with α-lactalbumin (a component of lactose synthase) in mammary epithelial cells, suggesting GLUT8 supplies glucose to the Golgi to support lactose synthesis. Immunohistochemistry, immunofluorescence co-localization with Golgi markers and lactose synthase component Journal of physiology and biochemistry Low 31020623
2002 GLUT8 protein is localized to dense core vesicles of synaptic nerve endings in supraoptic nucleus and secretory granules of vasopressin-positive neurons, specifically in vasopressin (but not oxytocin) neurons, as demonstrated by immunogold electron microscopy and double immunofluorescence. Immunogold labeling of ultrathin cryosections, double immunofluorescence microscopy Endocrinology Medium 11751619
2002 GLUT8 in spermatozoa is predominantly associated with the acrosomal region in both mouse and human sperm, with immunoreactivity at both the plasma membrane and intracellularly; expression onset in mouse testis coincides with appearance of mature spermatozoa. Immunohistochemistry with C-terminus-specific antiserum, developmental timing analysis Cell and tissue research Medium 11845330

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proceedings of the National Academy of Sciences of the United States of America 240 10860996
2000 GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. The Journal of biological chemistry 191 10821868
2000 GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. The Journal of biological chemistry 189 10671487
2012 Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood 157 22452979
2013 Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. The Journal of biological chemistry 101 23396969
2003 Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA. General and comparative endocrinology 95 12899849
2009 GLUT8, the enigmatic intracellular hexose transporter. American journal of physiology. Endocrinology and metabolism 94 19176349
2016 SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Scientific reports 87 27922102
2001 Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells. The Biochemical journal 85 11513753
2014 Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. The Journal of biological chemistry 83 24519932
2001 Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats. Proceedings of the National Academy of Sciences of the United States of America 83 11226324
2002 Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain. Brain research. Molecular brain research 81 12425944
2002 Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus. The Journal of comparative neurology 75 12271485
2005 GLUT8 contains a [DE]XXXL[LI] sorting motif and localizes to a late endosomal/lysosomal compartment. Traffic (Copenhagen, Denmark) 70 16262729
2012 GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovascular diabetology 68 22681646
2004 Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses. Placenta 66 15013641
2006 GLUT1 and GLUT8 in endometrium and endometrial adenocarcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 61 16892013
2002 Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons. Endocrinology 61 11751619
2002 The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. Cell and tissue research 60 11845330
2012 Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology 59 22822162
2016 Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway. Biology of reproduction 52 27535960
2007 The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and sperm. Reproductive sciences (Thousand Oaks, Calif.) 50 17913964
2006 GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function. Molecular and cellular biology 50 16705176
2004 Glucose transporter GLUT8 translocation in neurons is not insulin responsive. Journal of neuroscience research 50 14994344
2003 Regulation of hepatic GLUT8 expression in normal and diabetic models. Endocrinology 46 12697674
2002 GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. Brain research 46 11911870
2013 Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Molecular endocrinology (Baltimore, Md.) 45 24030250
2006 Differential expression of glucose transporter GLUT8 during mouse spermatogenesis. Reproduction (Cambridge, England) 43 16388010
2005 Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions. American journal of physiology. Renal physiology 40 15741607
2004 Bovine glucose transporter GLUT8: cloning, expression, and developmental regulation in mammary gland. Biochimica et biophysica acta 39 15488990
2009 Expression and regulation of insulin and the glucose transporter GLUT8 in the testes of diabetic rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 37 19194835
2014 Differential regulation of GLUT1 and GLUT8 expression by hypoxia in mammary epithelial cells. American journal of physiology. Regulatory, integrative and comparative physiology 36 24920730
2006 Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex. Journal of cell science 36 16723738
2004 Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus. Brain research 35 15047021
2012 Slc2a8 deficiency in mice results in reproductive and growth impairments. Biology of reproduction 33 22649075
2017 Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. Andrology 31 28471544
2001 Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose. Biochemical and biophysical research communications 30 11689004
2021 Placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in pregnancies complicated by gestational and type 1 diabetes mellitus. Journal of diabetes investigation 28 34555239
2010 Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex. Journal of anatomy 27 20819112
2003 GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. Pflugers Archiv : European journal of physiology 26 14704796
2005 GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons. Endocrinology 24 16109784
2009 Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction. The FEBS journal 23 19523115
2008 Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese hamster ovary cells. Traffic (Copenhagen, Denmark) 23 19076329
2022 Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis. Molecular metabolism 19 35123128
2018 Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. PloS one 19 29590129
2021 Differential Expression of Glucose Transporter Proteins GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in the Placenta of Macrosomic, Small-for-Gestational-Age and Growth-Restricted Foetuses. Journal of clinical medicine 18 34945129
2020 Alternative Splicing and Cleavage of GLUT8. Molecular and cellular biology 18 33077497
2018 Expression of glucose transporters SLC2A1, SLC2A8, and SLC2A12 in different chicken muscles during ontogenesis. Journal of animal science 16 29401234
2018 Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology 15 29596655
2009 Expression of GLUT8 in mouse intestine: identification of alternative spliced variants. Journal of cellular biochemistry 14 19229868
2011 Glucose transporters GLUT4 and GLUT8 are upregulated after facial nerve axotomy in adult mice. Journal of anatomy 13 21740425
2006 Glucose transporter 8 (GLUT8) from the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae). Archives of insect biochemistry and physiology 11 16703617
2010 The amino acids upstream of NH(2)-terminal dileucine motif play a role in regulating the intracellular sorting of the Class III transporters GLUT8 and GLUT12. Molecular membrane biology 10 21067453
2019 GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells. Journal of physiology and biochemistry 9 31020623
2015 AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle. Veterinary journal (London, England : 1997) 9 26116041
2024 The Impact of SLC2A8 RNA Interference on Glucose Uptake and the Transcriptome of Human Trophoblast Cells. Cells 2 38474355
2024 Opisthorchis viverrini excretory-secretory products suppress GLUT8 of cholangiocytes. Parasitology research 2 38491300
2014 Short communication: Protein kinase C regulates glucose uptake and mRNA expression of glucose transporter (GLUT) 1 and GLUT8 in lactating bovine mammary epithelial cells. Journal of dairy science 2 24819132
2017 Expression of glucose transporter 8 (GLUT8) in spermatogenesis of adult boar testes. Acta histochemica 1 28780960