Affinage

SLC16A1

Monocarboxylate transporter 1 · UniProt P53985

Length
500 aa
Mass
53.9 kDa
Annotated
2026-06-10
55 papers in source corpus 16 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC16A1 encodes MCT1, a proton-coupled monocarboxylate transporter that moves lactate, ketone bodies, 5-oxoproline, and related substrates across membranes and thereby couples cellular metabolism to intracellular pH homeostasis (PMID:7835905, PMID:25371203, PMID:29154783). Heterologous transport assays establish that MCT1 catalyzes H⁺-dependent uptake of 5-oxoproline and l-lactate with sub-millimolar affinity, and the common coding variant rs1049434 raises the Km for these substrates and the K0.5 for proton activation, demonstrating that single residues tune both substrate and proton handling (PMID:25371203, PMID:29154783). Its directionality is context-dependent: in glycolytic tumor cells MCT1-mediated lactate efflux maintains intracellular pH and is required for survival, such that inhibition or silencing collapses pH and triggers cell death (PMID:19427019, PMID:17000864), whereas in cardiac muscle MCT1 imports lactate directly into mitochondria for oxidation independently of the mitochondrial pyruvate carrier, and in the intervertebral disc it transfers lactate from nucleus pulposus to endplate cells to support metabolic coupling and growth. β-cell-specific overexpression of MCT1 is sufficient to cause exercise-induced hyperinsulinism by allowing pyruvate entry to drive inappropriate insulin secretion, explaining the basis of EIHI-associated SLC16A1 promoter mutations (PMID:22522610). MCT1 function is shaped by accessory and regulatory inputs: it physically associates with OAT10 (SLC22A13), acting as an efflux escape route that reshapes apparent OAT10 substrate selectivity (PMID:35926947), and it depends on the chaperone Basigin, whose support is negatively modulated by TMPRSS11B (PMID:40508207). SLC16A1 expression is controlled transcriptionally by PXR and by an ITCH→LATS1→YAP1 axis that governs pH-dependent cell death, and post-transcriptionally by miR-124 repression and by HNRNPA1-dependent mRNA stabilization (PMID:34298852, PMID:39179170, PMID:19427019, PMID:39247822). Downstream, MCT1-driven lactate flux engages STAT3/SLC7A11 and HCAR1/PI3K/AKT signaling in tumor cells and c-Raf/ERK-driven M2 macrophage polarization, linking lactate transport to proliferative and immunomodulatory programs (PMID:42065048, PMID:41840642, PMID:39247822).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1994 High

    Established the molecular identity and chromosomal location of human MCT1, providing the cloned reagent needed for all subsequent mechanistic work.

    Evidence cDNA cloning, PCR on somatic cell hybrid panels, and FISH mapping to 1p13.2-p12

    PMID:7835905

    Open questions at the time
    • No functional transport characterization in this study
    • No interactors or regulators identified
  2. 2006 Medium

    Tested whether MCT1-mediated lactate efflux is required for survival, showing that inhibition collapses intracellular pH and reduces viability in neuroblastoma.

    Evidence Intracellular pH measurement with pharmacological MCT inhibition and exogenous lactate in neuroblastoma cells

    PMID:17000864

    Open questions at the time
    • Pharmacological inhibitors are not MCT1-specific
    • Does not distinguish MCT1 from other MCT isoforms genetically
  3. 2009 Medium

    Identified a post-transcriptional brake on SLC16A1 and reinforced that its lactate-efflux function supports glycolytic cell survival.

    Evidence miR-124 transfection, 3'UTR luciferase reporter, and siRNA knockdown with viability readout in medulloblastoma cells

    PMID:19427019

    Open questions at the time
    • Single cell-type context
    • Physiological relevance of miR-124 regulation in vivo not established
  4. 2012 High

    Demonstrated causally that aberrant β-cell MCT1 expression triggers inappropriate insulin secretion, defining the disease mechanism of EIHI.

    Evidence Doxycycline-inducible β-cell-specific transgenic mouse with islet perifusion, pyruvate challenge, and exercise protocols

    PMID:22522610

    Open questions at the time
    • Models overexpression rather than the human promoter mutation directly
    • Does not address regulation that normally represses β-cell expression
  5. 2014 High

    Defined MCT1 substrate kinetics and showed that the common rs1049434 variant alters both substrate Km and proton affinity, giving the variant a functional consequence.

    Evidence Heterologous expression of WT and mutant SLC16A1 with radiolabeled transport and Michaelis-Menten analysis

    PMID:25371203

    Open questions at the time
    • In vitro kinetics; in vivo physiological impact of the variant not measured
    • Structural basis of altered proton coupling unknown
  6. 2017 Medium

    Confirmed MCT1 as the principal pH-dependent l-lactate transporter in human astrocytes using genetic-independent pharmacology and protein expression.

    Evidence Radiolabeled l-lactate uptake with selective inhibitors and immunohistochemistry in NHA cells

    PMID:29154783

    Open questions at the time
    • No genetic knockdown confirmation
    • Single cell model
  7. 2019 Medium

    Showed that MCT1 protein and lactate transport are under circadian control in retinal pigment epithelium, linking transporter abundance to tissue rhythms.

    Evidence Time-course protein/mRNA quantification and lactate measurement in ARPE-19 monolayers with photoreceptor outer segment incubation

    PMID:31678436

    Open questions at the time
    • No genetic manipulation of clock or SLC16A1
    • Mechanism linking clock to MCT1 protein levels not resolved
  8. 2021 Medium

    Placed SLC16A1 transcription under PXR control and showed it mediates intracellular drug accumulation, connecting the transporter to xenobiotic handling.

    Evidence PXR ChIP at the SLC16A1 promoter plus BAY-8002 inhibition and intracellular afatinib measurement in prostate cancer cells

    PMID:34298852

    Open questions at the time
    • Single lab and cell context
    • Direct transport of afatinib by MCT1 versus indirect effect not fully resolved
  9. 2022 Medium

    Identified a physical and functional partnership with OAT10, revealing MCT1 as an efflux escape route that reshapes a neighbouring transporter's apparent selectivity.

    Evidence Reciprocal co-IP/LC-MS/MS and siRNA knockdown with substrate uptake in HEK293 and oocytes

    PMID:35926947

    Open questions at the time
    • Physiological tissue where OAT10-MCT1 coupling operates not defined
    • Stoichiometry of the association unknown
  10. 2022 Medium

    Quantified the relative contribution of MCT1 versus MCT4 to hepatocellular carcinoma lactate transport, showing both operate as distinct kinetic systems.

    Evidence Isoform-selective siRNA knockdown with kinetic l-lactate uptake analysis in HepG2 and Huh-7 cells

    PMID:36104287

    Open questions at the time
    • Does not resolve directionality (import vs export) in situ
    • Single tumor-type context
  11. 2024 Medium

    Positioned SLC16A1 as a transcriptional output of an ITCH→LATS1→YAP1 axis that controls pH-dependent cell death (alkaliptosis).

    Evidence Nuclear proteomics with sequential shRNA knockdown and gain-of-function epistasis in PDAC cells

    PMID:39179170

    Open questions at the time
    • Direct YAP1 binding at the SLC16A1 locus not shown
    • Single lab
  12. 2024 Medium

    Revealed a non-canonical role in which exosomal lncRNA stabilizes SLC16A1 mRNA via HNRNPA1, driving lactate-ERK signaling and M2 macrophage polarization.

    Evidence RIP, mRNA stability assay, knockdown/overexpression, lactate influx and c-Raf/ERK readouts

    PMID:39247822

    Open questions at the time
    • In vivo relevance of macrophage reprogramming not fully established
    • HNRNPA1-SLC16A1 mRNA interaction mapped in single context
  13. 2024 Medium

    Linked MCT1 lactate transport to a STAT3→SLC7A11 axis conferring ferroptosis resistance and tumor growth in HNSCC.

    Evidence RNA-seq of knockdown cells, loss/gain-of-function, and xenograft assays

    PMID:42065048

    Open questions at the time
    • Mechanism by which MCT1 activates STAT3 not defined
    • Single tumor type
  14. 2024 Low

    Placed MCT1-mediated lactate export upstream of HCAR1/PI3K/AKT survival signaling in glioblastoma.

    Evidence siRNA knockdown in orthotopic rat GBM model with PI3K/AKT and apoptosis readouts

    PMID:41840642

    Open questions at the time
    • Pathway placement indirect from knockdown phenotype
    • Single lab, no rescue experiment
  15. 2025 Medium

    Identified TMPRSS11B as a negative regulator of Basigin-supported MCT1 lactate uptake, adding a new layer of post-translational control.

    Evidence shRNA knockdown, overexpression, and iLACCO1 lactate biosensor epistasis in PDAC cells

    PMID:40508207

    Open questions at the time
    • Molecular mechanism by which TMPRSS11B acts on BSG/MCT1 not defined
    • Single lab
  16. 2025 Medium

    Demonstrated in vivo that MCT1 mediates nucleus pulposus-to-endplate lactate transfer driving metabolic coupling and histone lactylation essential for disc growth.

    Evidence Conditional Slc16a1 knockout mouse with histology, spatial transcriptomics, and lactylation immunodetection (preprint)

    Open questions at the time
    • Preprint, single lab
    • Directionality of lactate flux inferred rather than directly traced
  17. 2024 Medium

    Established MCT1 as essential for mitochondrial lactate import and oxidation in the heart, independent of the mitochondrial pyruvate carrier.

    Evidence 13C tracing, MPC and cardiac MCT1 deletion, isolated mitochondrial assays, and cardiac function monitoring (preprint)

    Open questions at the time
    • Preprint, single lab
    • Mechanism of MCT1 targeting to mitochondrial membrane not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MCT1 directionality (import vs export) and substrate preference are set in a given tissue, and the structural basis of its proton coupling, remain unresolved.
  • No high-resolution structure or proton-coupling mechanism in the corpus
  • Determinants switching between lactate efflux (tumor pH homeostasis) and mitochondrial/import roles unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 6 GO:0140104 molecular carrier activity 4
Localization
GO:0005886 plasma membrane 4 GO:0005739 mitochondrion 1
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-382551 Transport of small molecules 4 R-HSA-5357801 Programmed Cell Death 4
Partners
BSGHNRNPA1SLC22A13TMPRSS11B

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 Human MCT1/SLC16A1 cDNA was cloned and the protein shown to be 86% identical to hamster MCT1; the SLC16A1 locus was mapped to chromosome 1p13.2-p12 by PCR on human×rodent hybrid cell panels and fluorescence in situ hybridization. cDNA cloning, PCR on somatic cell hybrid panels, FISH Genomics High 7835905
2012 Transgenic β-cell-specific overexpression of MCT1/SLC16A1 in mice is sufficient to cause exercise-induced hyperinsulinism (EIHI): isolated islets secreted insulin in response to pyruvate, fasting blood glucose was lowered in vivo, pyruvate challenge raised plasma insulin, and exercise failed to suppress insulin secretion—directly demonstrating that pyruvate entry via MCT1 triggers inappropriate insulin secretion and explaining the mechanism of EIHI-associated SLC16A1 promoter mutations. Doxycycline-inducible β-cell-specific transgenic mouse, ex vivo islet perifusion, in vivo pyruvate challenge, exercise protocol, blood glucose/insulin measurement Diabetes High 22522610
2014 SLC16A1/MCT1 mediates H⁺-coupled transport of 5-oxoproline; the common polymorphism rs1049434 increases the Km for 5-oxoproline and lactate and increases the K0.5 for proton activation compared to wild-type, demonstrating a functional consequence of this variant on transporter kinetics. In T98G astrocyte-model cells, 5-oxoproline uptake is mediated solely by SLC16A1. Heterologous expression of wild-type and mutant SLC16A1, radiolabeled substrate transport assay, Michaelis-Menten kinetics, inhibitor studies in T98G cells The Journal of biological chemistry High 25371203
2016 Atorvastatin is a non-competitive inhibitor of SLC16A1-mediated 5-oxoproline/lactate transport with an inhibition constant of ~40 µM, indicating it binds outside the substrate recognition site; however, the affinity is low enough that clinical interactions are unlikely. Heterologous SLC16A1 expression in mammalian cells and Xenopus oocytes, [³H]-5-oxoproline transport inhibition assay, Ki determination European journal of pharmacology Medium 27341998
2017 In human astrocytes (NHA cells), pH-dependent l-lactate uptake (Km ~0.64 mM) is mediated primarily by MCT1/SLC16A1, as shown by inhibition with the selective MCT1 inhibitors α-cyano-4-hydroxycinnamate and 5-oxoproline, and confirmed by MCT1 protein expression via immunohistochemistry. Radiolabeled l-lactate uptake assay, pharmacological inhibition, immunohistochemistry Life sciences Medium 29154783
2019 The circadian clock in retinal pigment epithelial cells regulates SLC16A1/MCT1 protein levels and apical lactate transport in a rhythmic manner; MCT1 protein (but not GLUT1) oscillated over time in ARPE-19 monolayers, and apical lactate concentrations were rhythmic and correlated with SLC16A1 mRNA expression. Photoreceptor outer segment (POS) incubation modulated SLC16A1 mRNA in a time-dependent fashion, suggesting the retina regulates RPE lactate transport via POS-RPE interaction. ARPE-19 monolayer culture, time-course protein and mRNA quantification, spectrophotometric lactate measurement, POS incubation experiment Experimental eye research Medium 31678436
2021 PXR (Pregnane X Receptor) binds the SLC16A1 promoter and transcriptionally induces SLC16A1 expression in the presence of PXR agonists; pharmacological inhibition of SLC16A1 by BAY-8002 suppressed PXR-mediated sensitization of prostate cancer cells to afatinib and reduced intracellular afatinib accumulation, demonstrating that SLC16A1 mediates intracellular drug accumulation downstream of PXR. Stable PXR overexpression, ChIP assay (PXR binding to SLC16A1 promoter), pharmacological inhibition (BAY-8002), intracellular drug concentration measurement, cell viability assay Cancers Medium 34298852
2022 OAT10 (SLC22A13) physically associates with MCT1/SLC16A1 in HEK293 cells, as identified by co-immunoprecipitation followed by LC-MS/MS. MCT1 knockdown increased OAT10-mediated uptake of β-hydroxybutyrate and nicotinate (shared substrates), but not orotate (OAT10-only substrate), indicating MCT1 acts as an efflux escape route for substrates taken up by nearby OAT10, functionally altering apparent OAT10 substrate selectivity. Co-immunoprecipitation / LC-MS/MS, siRNA knockdown, substrate uptake assay in Xenopus oocytes and HEK293 cells Journal of pharmacological sciences Medium 35926947
2022 Both MCT1/SLC16A1 and MCT4 contribute to pH-dependent l-lactate transport in hepatocellular carcinoma cells (HepG2, Huh-7); selective knockdown of MCT1 or MCT4 (but not MCT2) decreased l-lactate uptake, and kinetic analysis revealed biphasic uptake consistent with two distinct transporter systems operating simultaneously. siRNA knockdown, radiolabeled l-lactate uptake, pharmacological inhibitors, kinetic (Michaelis-Menten) analysis Biopharmaceutics & drug disposition Medium 36104287
2024 ITCH E3 ubiquitin ligase inhibits alkaliptosis (pH-dependent cell death) in pancreatic ductal adenocarcinoma cells by blocking LATS1 ubiquitination, which in turn suppresses YAP1-dependent transcriptional activation of SLC16A1; SLC16A1 upregulation by YAP1 inhibits JTC801-induced alkaliptosis, establishing an ITCH→LATS1→YAP1→SLC16A1 signaling axis that controls intracellular pH homeostasis. Proteomics of nuclear fractions, shRNA knockdown of ITCH and pathway components, overexpression, cell viability and death assays, Western blot The international journal of biochemistry & cell biology Medium 39179170
2024 In HCC exosomes, SLC16A1-AS1 lncRNA enhances mRNA stabilization of SLC16A1 in macrophages by promoting interaction between the 3'UTR of SLC16A1 mRNA and the RNA-binding protein HNRNPA1; elevated SLC16A1 in macrophages accelerates lactate influx and activates c-Raf/ERK signaling to induce M2 polarization, establishing a non-canonical role of lactate transport via SLC16A1 in macrophage reprogramming. RNA immunoprecipitation, co-immunoprecipitation, mRNA stability assay, SLC16A1 knockdown/overexpression, lactate influx assay, c-Raf/ERK signaling readout International journal of biological sciences Medium 39247822
2025 TMPRSS11B modulates lactate import through SLC16A1 in pancreatic ductal adenocarcinoma cells: shRNA-mediated TMPRSS11B knockdown enhanced lactate import via SLC16A1 (measured by GFP/iLACCO1 lactate uptake assay), whereas TMPRSS11B overexpression dampened SLC16A1-driven lactate uptake; both effects depended on SLC16A1 and its chaperone Basigin (BSG), establishing TMPRSS11B as a negative regulator of BSG-supported SLC16A1 lactate transport. shRNA knockdown, overexpression, iLACCO1 fluorescent lactate biosensor assay, gene silencing epistasis, immunohistochemistry International journal of molecular sciences Medium 40508207
2024 SLC16A1 activates STAT3, which transcriptionally upregulates SLC7A11 in HNSCC cells; this SLC16A1→STAT3→SLC7A11 axis promotes ferroptosis resistance and tumor growth, as established by RNA sequencing of SLC16A1-knockdown cells, loss- and gain-of-function experiments, and xenograft assays. RNA sequencing, shRNA/siRNA knockdown, overexpression, in vitro and xenograft in vivo functional assays, Western blot, RT-qPCR Oncology research Medium 42065048
2009 miR-124 directly represses SLC16A1 expression: transfection of miR-124 in medulloblastoma cells reduced SLC16A1 mRNA and protein levels, and a luciferase reporter assay with the SLC16A1 3'UTR confirmed direct miR-124 binding; siRNA-mediated SLC16A1 knockdown independently induced cell death, suggesting SLC16A1 lactate-efflux function is required for cell survival during aerobic glycolysis. Transfection of miR-124, qRT-PCR, Western blot, 3'UTR luciferase reporter assay, siRNA knockdown, cell viability assay Human pathology Medium 19427019
2006 MCT1/SLC16A1 inhibition (via lonidamine or exogenous lactate at acidic pH) lowered intracellular pH in neuroblastoma cells and correlated with reduced cell viability, and this mechanism of cell death was similar to that produced by the established MCT inhibitor α-cyano-4-OH-cinnamate, implicating MCT1-mediated lactate efflux as required for pH homeostasis and survival in neuroblastoma. Intracellular pH measurement (fluorescent dye), pharmacological MCT inhibition (lonidamine, α-cyano-4-OH-cinnamate), exogenous lactate treatment, cell viability assay Molecular pharmacology Medium 17000864
2024 In an orthotopic glioblastoma model, SLC16A1 silencing induced intracellular lactate accumulation, suppressed lactate-stimulated HCAR1/PI3K/AKT signaling, and promoted apoptosis both in vitro and in vivo, placing SLC16A1-mediated lactate export upstream of HCAR1/PI3K/AKT survival signaling. siRNA-mediated SLC16A1 knockdown, orthotopic rat GBM model, Western blot (PI3K/AKT pathway), apoptosis assay, histological analysis Journal of nanobiotechnology Low 41840642
2025 Conditional knockout of Mct1 (Slc16a1) specifically in annulus fibrosus and endplate cells of mice caused significant intervertebral disc degeneration with nucleus pulposus cell loss and delayed endplate maturation; endplate cells metabolized lactate and showed lactate-promoted H3K18 lactylation, demonstrating that MCT1-dependent lactate transport from nucleus pulposus cells to endplate cells mediates metabolic coupling essential for disc growth. Conditional knockout mouse (Slc16a1 Col2CreERT2), histology, spatial transcriptomics, metabolic assays, lactylation immunodetection bioRxivpreprint Medium
2024 MCT1/SLC16A1 mediates direct mitochondrial import of lactate in the myocardium independently of the mitochondrial pyruvate carrier (MPC); isolated mitochondria from hearts lacking MCT1 showed a specific defect in mitochondrial lactate (but not pyruvate) metabolism, and cardiac MCT1 deletion caused rapid progression to heart failure under stress, establishing MCT1 as essential for mitochondrial lactate oxidation and cardiac energetics. 13C stable isotope tracing, MPC genetic deletion, MCT1 cardiac-specific knockout, mitochondrial isolation and functional assays, cardiac function monitoring bioRxivpreprint Medium

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1. Human pathology 143 19427019
2006 The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Molecular pharmacology 140 17000864
1994 cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics 81 7835905
2020 LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1. Theranostics 80 32863950
2012 Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise. Diabetes 80 22522610
2022 Silencing lncRNA SLC16A1-AS1 Induced Ferroptosis in Renal Cell Carcinoma Through miR-143-3p/SLC7A11 Signaling. Technology in cancer research & treatment 60 35167383
2014 Functional characterization of 5-oxoproline transport via SLC16A1/MCT1. The Journal of biological chemistry 48 25371203
2016 Heat stress-induced autophagy promotes lactate secretion in cultured immature boar Sertoli cells by inhibiting apoptosis and driving SLC2A3, LDHA, and SLC16A1 expression. Theriogenology 39 27751602
2016 Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4). Archives of biochemistry and biophysics 38 26854723
2020 Long non-coding RNA SLC16A1-AS1: its multiple tumorigenesis features and regulatory role in cell cycle in oral squamous cell carcinoma. Cell cycle (Georgetown, Tex.) 35 32450050
2022 Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). Journal of medicinal chemistry 30 36584238
2020 Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene. Carcinogenesis 27 31605138
2024 Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression. International journal of biological sciences 23 39247822
2020 SLC16A1-AS1 enhances radiosensitivity and represses cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma. Environmental science and pollution research international 20 32748357
2021 LncRNA SLC16A1-AS1 is Upregulated in Glioblastoma and Promotes Cancer Cell Proliferation by Regulating miR-149 Methylation. Cancer management and research 19 33603467
2017 Involvement of monocarboxylate transporter 1 (SLC16A1) in the uptake of l-lactate in human astrocytes. Life sciences 16 29154783
2015 Heterozygous Monocarboxylate Transporter 1 (MCT1, SLC16A1) Deficiency as a Cause of Recurrent Ketoacidosis. JIMD reports 16 26608392
2022 LncRNA SLC16A1-AS1 regulates the miR-182/PDCD4 axis and inhibits the triple-negative breast cancer cell cycle. Immunopharmacology and immunotoxicology 15 35316129
2021 PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1. Cancers 15 34298852
2019 The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1). Experimental eye research 15 31678436
2022 Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line. Biopharmaceutics & drug disposition 14 36104287
2009 Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore. Drug metabolism and pharmacokinetics 13 19881260
2019 A SLC16A1 Mutation in an Infant With Ketoacidosis and Neuroimaging Assessment: Expanding the Clinical Spectrum of MCT1 Deficiency. Frontiers in pediatrics 12 31380330
2022 Overexpression of lncRNA SLC16A1-AS1 Suppresses the Growth and Metastasis of Breast Cancer via the miR-552-5p/WIF1 Signaling Pathway. Frontiers in oncology 11 35372039
2021 Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas. Journal of molecular neuroscience : MN 10 33641091
2022 LncRNA SLC16A1-AS1 contributes to the progression of hepatocellular carcinoma cells by modulating miR-411/MITD1 axis. Journal of clinical laboratory analysis 9 35293026
2021 LncRNA SLC16A1-AS1 Suppresses Cell Proliferation in Cervical Squamous Cell Carcinoma (CSCC) Through the miR-194/SOCS2 Axis. Cancer management and research 8 33603475
2018 Genetic variations in the monocarboxylate transporter genes (SLC16A1, SLC16A3, and SLC16A11) in the Japanese population. Drug metabolism and pharmacokinetics 8 30177396
2015 Variants of the Solute Carrier SLC16A1 Gene (MCT1) Associated With Metabolic Responses During a Long-Graded Test in Road Cyclists. Journal of strength and conditioning research 8 26595136
2022 Analysis of the subcellular location of lncRNA SLC16A1-AS1 and its interaction with premature miR-5088-5p in oral squamous cell carcinoma. Odontology 7 35829849
2022 Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10. Journal of pharmacological sciences 7 35926947
2019 Rno-miR-425-5p targets the DLST and SLC16A1 genes to reduce liver damage caused by excessive energy mobilization under cold stress. Journal of animal physiology and animal nutrition 7 31087708
2024 Exploring SLC16A1 as an Oncogenic Regulator and Therapeutic Target in Cholangiocarcinoma. Journal of Cancer 6 38911368
2023 Construction of SLC16A1/3 Targeted Gallic Acid-Iron-Embelin Nanoparticles for Regulating Glycolysis and Redox Pathways in Cervical Cancer. Molecular pharmaceutics 6 37307591
2020 Variation in the SLC16A1 and the ACOX1 Genes Is Associated with Gallop Racing Performance in Arabian Horses. Journal of equine veterinary science 6 32972674
2019 The use of the SLC16A1 gene as a potential marker to predict race performance in Arabian horses. BMC genetics 6 31510920
2022 MicroRNA-1269 is downregulated in glioblastoma and its maturation is regulated by long non-coding RNA SLC16A1 Antisense RNA 1. Bioengineered 5 35609320
2024 Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis. Cellular & molecular biology letters 4 38539084
2024 ITCH inhibits alkaliptosis in human pancreatic cancer cells through YAP1-dependent SLC16A1 activation. The international journal of biochemistry & cell biology 4 39179170
2016 Interaction of atorvastatin with the human glial transporter SLC16A1. European journal of pharmacology 4 27341998
2025 Transmembrane Protease Serine 11B Modulates Lactate Transport Through SLC16A1 in Pancreatic Ductal Adenocarcinoma-A Functional Link to Phenotype Heterogeneity. International journal of molecular sciences 3 40508207
2024 EP300 regulates the SLC16A1-AS1-AS1/TCF3 axis to promote lung cancer malignancies through the Wnt signaling pathway. Heliyon 3 38515708
2024 Biological roles of SLC16A1-AS1 lncRNA and its clinical impacts in tumors. Cancer cell international 3 38555465
2023 MiR-526b targets lncRNA SLC16A1-AS1 to suppress cell proliferation in triple-negative breast cancer. Journal of biochemical and molecular toxicology 3 36654514
2024 The polymorphism T1470A of the SLC16A1 gene is associated with the lactate and ventilatory thresholds but not with fat oxidation capacity in young men. European journal of applied physiology 2 38216723
2022 Effect of SLC16A1 on Hepatic Glucose Metabolism in Newborn and Post-Weaned Holstein Bulls. Frontiers in genetics 2 35664312
2026 SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. Oncology research 1 42065048
2025 Hypoglycaemia following physical exercise in a patient with novel SLC16A1 variant. European journal of endocrinology 1 39715334
2025 The association of SLC16A1 (MCT1) gene polymorphism with body composition changes during weight loss interventions: A randomized trial with sex-dependent analysis. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 1 39787575
2025 SLC16A1 Inhibits Ferroptosis and Promotes the Progression of Head and Neck Squamous Cell Carcinoma. Journal of Cancer 1 40302798
2024 LncRNA SLC16A1-AS1 participates in the initiation and progression of colorectal cancer by regulating MAP3K9 expression through targeting miR-515-5p. American journal of cancer research 1 39659936
2026 LncRNA SLC16A1-AS1 cooperates with NSUN2 to stabilize GRP78 mRNA via m5C modification in gastric cancer. iScience 0 41727188
2026 tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress. Journal of nanobiotechnology 0 41840642
2025 Genotype and Clinical Phenotype of Monocarboxylate Transporter 1 Deficiency in Three Palestinian Children: Report of Two Novel Variants in the SLC16A1 Gene. American journal of medical genetics. Part A 0 40464101
2025 Muscle Oxygen Saturation Responses During Maximal and Submaximal Exercise According to SLC16A1 (MCT1) Gene Polymorphism in Long-Distance Runners: A Cross-Sectional Pilot Study. Genes 0 41300776

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