Affinage

SLAMF1

Signaling lymphocytic activation molecule · UniProt Q13291

Length
335 aa
Mass
37.2 kDa
Annotated
2026-04-28
100 papers in source corpus 25 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLAMF1 (CD150) is a homophilic immunoglobulin-superfamily receptor that orchestrates adaptive and innate immune responses by coupling antigen receptor signaling to cytokine polarization, cytotoxicity, autophagy, and pathogen handling on T cells, B cells, NKT cells, and myeloid cells. Homotypic SLAMF1–SLAMF1 engagement recruits the adaptor SAP, whose SH2 domain binds cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs) and simultaneously docks FynT via a non-canonical SH2–SH3 interaction, activating a downstream phosphorylation cascade involving SHIP, Dok1/2, Shc, and RasGAP that drives IL-4 and IFN-γ production, granule-dependent cytotoxicity, and NKT cell lineage development (PMID:9774102, PMID:11477403, PMID:12545174, PMID:18031695, PMID:20525889). In myeloid cells, SLAMF1 promotes Nox2-dependent ROS production and autophagy through a Beclin-1–VPS34 macrocomplex, regulates intracellular replication of pathogens such as Trypanosoma cruzi and Brucella abortus, and is exploited by morbilliviruses—including measles, canine distemper, and rinderpest viruses—as the primary entry receptor via direct hemagglutinin binding that triggers macropinocytosis-like internalization (PMID:10972291, PMID:11390585, PMID:26619119, PMID:25799045, PMID:22807679, PMID:31953913, PMID:28100610). Loss-of-function mutations in SAP (SH2D1A), which uncouples SLAMF1 signaling and shifts the pathway toward inhibitory SHP-1/SHP-2 recruitment, cause X-linked lymphoproliferative disease (PMID:9774102, PMID:22683123).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1997 Medium

    Establishing that SLAMF1 undergoes homophilic (self-ligand) interaction and that this engagement costimulates B cell proliferation and immunoglobulin production resolved the question of the receptor's natural ligand and placed SLAMF1 as a lymphocyte costimulatory molecule.

    Evidence Recombinant soluble SLAMF1 and SLAMF1-transfected L cells in B cell proliferation/Ig secretion assays

    PMID:9091591

    Open questions at the time
    • Structural basis of homophilic interaction not defined
    • Signaling events downstream of B cell engagement not characterized
  2. 1998 High

    Identification of SAP as an SH2-domain adaptor that binds the SLAMF1 cytoplasmic tail and blocks SHP-2 recruitment—and its mutational loss in XLP patients—established the first signaling mechanism downstream of SLAMF1 and linked it to human immunodeficiency.

    Evidence Co-immunoprecipitation, SH2 domain binding assays, and patient mutational analysis

    PMID:9774102

    Open questions at the time
    • Kinase effectors downstream of SAP–SLAMF1 unknown
    • Whether SAP loss rewires rather than merely ablates signaling was unresolved
  3. 2000 High

    Demonstrating that SLAMF1 cDNA transfection confers measles virus susceptibility to resistant cells resolved the identity of the primary wild-type measles virus entry receptor, a long-standing question in morbillivirus biology.

    Evidence Heterologous expression of SLAMF1 in non-susceptible cell lines followed by MV binding and infection assays

    PMID:10972291

    Open questions at the time
    • Molecular interface between hemagglutinin and SLAMF1 undefined
    • Whether other morbilliviruses share SLAM usage unknown at this point
  4. 2001 High

    Multiple studies established that SLAMF1 signaling proceeds through a SAP-dependent phosphorylation cascade (FynT, SHIP, Dok1/2, RasGAP) that controls cytokine production and T cell cytotoxicity, and that SLAMF1 serves as a shared morbillivirus receptor across species.

    Evidence SAP-deficient/reconstituted T cell signaling assays, pharmacological inhibition of MEK1/2 and calcium, pseudotype entry assays with species-specific SLAM orthologs

    PMID:11312320 PMID:11390585 PMID:11477403 PMID:11536173 PMID:11714966

    Open questions at the time
    • How SAP couples to FynT mechanistically remained unclear
    • Contribution of individual downstream effectors (e.g., Dok vs SHIP) not dissected in vivo
  5. 2003 High

    The crystal structure of the ternary SLAM–SAP–Fyn-SH3 complex revealed a non-canonical SH2–SH3 surface interaction through which SAP recruits and activates FynT, explaining how an adaptor lacking enzymatic activity transduces SLAMF1 signals.

    Evidence X-ray crystallography of ternary complex with in vitro binding validation

    PMID:12545174

    Open questions at the time
    • Ternary complex formation not demonstrated in intact cells with endogenous proteins at that time
    • Whether the same mechanism applies at all SLAM-family receptors not tested
  6. 2004 High

    Dissection of SLAMF1 signaling in B cells showed SH2D1A-dependent switching between ERK (via SHIP) and Akt (via Syk) pathways, with Lyn phosphorylating SLAMF1 Y327, demonstrating that SLAMF1 operates as a signaling platform whose output depends on adapter availability.

    Evidence DT40 B cell knockout sublines for individual kinases/adaptors with phosphorylation and pathway-specific readouts

    PMID:15315965

    Open questions at the time
    • Relevance of Y327 phosphorylation in primary B cells not validated
    • Integration of ERK vs Akt branches in physiological B cell responses unclear
  7. 2007 High

    Genetic epistasis in knockout mice demonstrated that SLAMF1 (with SLAMF6) provides essential thymocyte-derived costimulatory signals for NKT cell lineage development via SAP-Fyn recruitment, and that SLAMF1 lipid-raft localization in CD8+ T cells enhances cytotoxicity and IFN-γ production.

    Evidence Multiple knockout/chimeric mice for NKT analysis; lipid raft fractionation, overexpression/siRNA, and xenograft models for CD8+ T cells

    PMID:17692919 PMID:18031695

    Open questions at the time
    • Relative contributions of SLAMF1 vs SLAMF6 to NKT development not fully separated
    • Mechanism linking lipid raft localization to enhanced signaling not biochemically defined
  8. 2008 High

    Identification of hemagglutinin residue I194 as the primary SLAMF1-binding determinant and a distinct fusion-triggering site on blade 5 established a two-step model of MV entry (binding then conformational change), while NOD mouse studies showed that reduced SLAMF1 on dendritic cells impairs NKT2 polarization via defective GATA-3 induction.

    Evidence Site-directed mutagenesis with SPR and fusion assays for MV entry; cross-strain DC–NKT co-culture for NOD phenotype

    PMID:18292085 PMID:18606638

    Open questions at the time
    • Full atomic structure of SLAMF1–hemagglutinin complex not yet solved
    • Whether NOD SLAMF1 defect is solely expression-level or includes functional polymorphism unclear
  9. 2012 High

    SLAMF1 was shown to regulate immunological synapse organization in cytotoxic lymphocytes: in the absence of SAP, SLAM-family signaling recruits SHP-1 instead of Fyn, impairing actin clearance and B cell killing; separately, SLAMF1 on myeloid cells was found essential for intracellular Trypanosoma cruzi replication, with knockout mice fully protected from lethal challenge.

    Evidence SAP-deficient mouse CD8+ T cell synapse imaging and cytotoxicity assays; Slamf1 KO mice and anti-SLAMF1 antibody blockade in T. cruzi infection

    PMID:22683123 PMID:22807679

    Open questions at the time
    • How SLAMF1 promotes parasite replication at the molecular level unknown
    • Relative contribution of SHP-1 vs loss of Fyn to cytotoxic defect not separated
  10. 2015 High

    SLAMF1 was placed as a positive regulator of autophagy (via a Beclin-1–VPS34 macrocomplex and ROS/p38/JNK signaling) and Nox2-dependent ROS production in myeloid cells, while triple SLAM-family knockout studies revealed SLAMF1 as a negative regulator of humoral responses, adding B-cell-intrinsic suppressive function to its portfolio.

    Evidence RNAi/agonistic antibody in CLL cells with co-IP of SLAMF1–Beclin-1–VPS34; Slamf1 KO myeloid ROS and migration assays; triple KO adoptive transfer for antibody responses

    PMID:25799045 PMID:25926831 PMID:26619119

    Open questions at the time
    • How Beclin-1 is recruited to SLAMF1 (direct vs indirect) not established
    • Mechanism by which SLAMF1 restrains antibody responses at the molecular level unresolved
  11. 2017 High

    Demonstrating that MV engagement of SLAMF1 triggers a macropinocytosis-like entry pathway via RhoA–ROCK–myosin II defined the cell-biological mechanism of SLAMF1-mediated viral internalization, beyond simple receptor binding.

    Evidence Live-cell imaging and pharmacological inhibition of actin dynamics and RhoA–ROCK–myosin II pathway in SLAMF1+ cells during MV infection

    PMID:28100610

    Open questions at the time
    • Whether this entry pathway is shared by all morbilliviruses not tested
    • SLAMF1 cytoplasmic domain signaling events that trigger macropinocytosis not defined
  12. 2019 High

    Comprehensive SFR-knockout and single-gene rescue experiments showed that SLAMF6, more than SLAMF1, is the critical family member reducing TCR signal strength to permit iNKT survival after positive selection, refining the earlier model of redundant SLAMF1/SLAMF6 roles in NKT development.

    Evidence Seven-SFR-deficient mice with SLAMF6 single rescue, epistasis with SAP-Fyn and SHP-1

    PMID:30833791

    Open questions at the time
    • Whether SLAMF1 has any non-redundant role in iNKT development beyond SLAMF6 remains unclear
    • Cell-type-specific redundancy among SFRs in humans not addressed
  13. 2020 High

    SLAMF1 was identified as a direct target of bacterial immune evasion (Brucella Omp25 binds SLAMF1 to suppress NF-κB and DC activation) and as a promoter of neutrophil autophagy during M. tuberculosis infection, extending its microbial-sensor role to chronic bacterial pathogens.

    Evidence In vitro Omp25–SLAMF1 binding assays and in vivo Brucella persistence models; SLAMF1–LC3B colocalization and agonistic antibody stimulation in Mtb-exposed neutrophils

    PMID:31953913 PMID:32954947

    Open questions at the time
    • Omp25–SLAMF1 binding interface not structurally defined
    • Whether SLAMF1-driven autophagy in neutrophils restricts Mtb growth in vivo unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the atomic structure of the SLAMF1 homophilic interface, the mechanism by which SLAMF1 cytoplasmic signals trigger macropinocytosis and autophagy complex assembly, and how SLAMF1 restrains humoral immune responses at the molecular level.
  • No high-resolution structure of SLAMF1 homophilic complex
  • Mechanism linking SLAMF1 cytoplasmic domain to Beclin-1–VPS34 recruitment unknown
  • Molecular basis of B-cell-intrinsic antibody suppression undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0001618 virus receptor activity 3 GO:0098631 cell adhesion mediator activity 3
Localization
GO:0005886 plasma membrane 5 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-168256 Immune System 8 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-9612973 Autophagy 2 R-HSA-5357801 Programmed Cell Death 1
Partners
BECN1DOK1DOK2FYNLYNPIK3C3SH2D1ASHIP1
Complex memberships
SLAMF1–Beclin-1–VPS34 autophagy macrocomplexSLAMF1–SAP–FynT ternary signaling complex

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 SLAMF1 (CD150/SLAM) functions as a cellular receptor for measles virus; transfection of human SLAMF1 cDNA into non-susceptible cell lines enabled measles virus binding, replication, and cytopathic effects, establishing SLAMF1 as the entry receptor for wild-type measles virus strains. Transfection of SLAMF1 cDNA into resistant cell lines followed by virus binding and infection assays Nature High 10972291
1998 SAP (SLAM-associated protein) binds to the SLAMF1 cytoplasmic region via its SH2 domain, acting as an inhibitor that blocks recruitment of SHP-2 to SLAMF1, thereby regulating SLAM-mediated signaling; SAP gene mutations were found in XLP patients, linking defective SLAMF1 signaling regulation to the disease. Co-immunoprecipitation, SH2 domain binding assays, patient mutational analysis Nature High 9774102
2001 SLAMF1 receptor engagement triggers protein tyrosine phosphorylation signaling in T cells strictly dependent on SAP expression; this signal involves SHIP, Dok2, Dok1, Shc, and RasGAP, with SAP facilitating selective recruitment and activation of Src-related kinase FynT to SLAMF1; signaling via this pathway alters cytokine production profile during T cell activation. T cell signaling assays with SAP-deficient and reconstituted cell lines, phosphorylation assays, cytokine production measurement Nature immunology High 11477403
2003 SAP couples FynT to SLAMF1 by binding the SH3 domain of FynT through the SAP SH2 domain via a non-canonical surface-surface interaction; a crystal structure of a ternary SLAM-SAP-Fyn-SH3 complex revealed this interaction mode and showed that SAP binding precludes the auto-inhibited conformation of Fyn, promoting kinase activation after recruitment. Crystal structure determination of ternary complex, in vitro binding assays Nature cell biology High 12545174
2001 SLAMF1 (CD150) is used as a cellular receptor by canine distemper virus and rinderpest virus (acting on their respective host species SLAM orthologs), demonstrating that SLAM usage as a receptor is a common property of morbilliviruses; virus entry via SLAM was confirmed by pseudotype assays. Expression of species-specific SLAM in CHO cells, infection assays, VSV pseudotype entry assays Journal of virology High 11390585
2007 Homotypic interactions mediated by Slamf1 (SLAM) and Slamf6 (Ly108) between thymocytes provide 'second signals' during TCR engagement that recruit SAP and Fyn kinase, which are essential for NKT cell lineage expansion and differentiation; this cosignaling pathway is only available when selecting ligands are presented by thymocytes (not epithelial cells) because stromal cells do not express Slamf1/Slamf6. Genetic knockout mice, bone marrow chimeras, flow cytometric analysis of NKT development, epistasis experiments Immunity High 18031695
2010 SLAMF1 (CD150) receptor ligation on germinal center T follicular helper (GC TFH) cells is specifically required for IL-4 production by these cells, as demonstrated by SLAM-deficient mice that lacked IL-4 production in GC TFH cells despite only a moderate defect in TFH differentiation. SLAM knockout mouse analysis, flow cytometry, intracellular cytokine staining Journal of immunology High 20525889
2002 The measles virus hemagglutinin (H protein) is responsible for downregulating SLAMF1 from the cell surface after infection; transfection of hemagglutinin expression plasmid alone induced SLAM downregulation in cells expressing or coming in contact with hemagglutinin-expressing cells, while the fusion protein had no such effect. Transfection of individual MV envelope proteins, flow cytometric measurement of surface SLAM expression Archives of virology Medium 11855632
2008 Measles virus hemagglutinin isoleucine 194 is essential for primary binding to SLAMF1 (measured by surface plasmon resonance); after binding, a quartet of residues on propeller blade 5 mediates receptor-specific conformational changes required for membrane fusion, establishing distinct binding and fusion-triggering sites on the hemagglutinin-SLAMF1 interface. Site-directed mutagenesis, surface plasmon resonance, receptor-specific fusion assays, crystal structure localization of residues The Journal of biological chemistry High 18292085
2004 CD150 (SLAMF1) ligation in DT40 B cells induces ERK signaling requiring SHIP but not SH2D1A, while CD150-mediated Akt phosphorylation requires Syk and SH2D1A and is negatively regulated by Lyn and Btk; Lyn directly phosphorylates Y327 in the SLAMF1 cytoplasmic tail, demonstrating SH2D1A-dependent switching of SLAMF1 downstream signaling pathways. DT40 B cell knockout sublines, phosphorylation assays, kinase-specific inhibitors, direct kinase phosphorylation assay Blood High 15315965
2015 SLAMF1 ligation in CLL cells with an agonistic monoclonal antibody induces ROS accumulation, phosphorylation of p38, JNK1/2, and BCL2, and promotes autophagic flux; mechanistically, Beclin1 dissociates from BCL2 upon SLAMF1 ligation, leading to formation of an autophagy macrocomplex containing SLAMF1, Beclin1, and VPS34; SLAMF1-silenced cells showed increased CXCR4, CD38, and CD44 expression and enhanced chemotactic responses to CXCL12. SLAMF1 silencing (RNAi), agonistic antibody ligation, co-immunoprecipitation, immunoblotting, autophagy flux assays, migration assays The Journal of clinical investigation High 26619119
2015 Slamf1 and Slamf8 differentially regulate NADPH-oxidase (Nox2)-dependent reactive oxygen species (ROS) production by myeloid cells in response to bacteria; Slamf1 is required for optimal ROS production and promotes myeloid cell migration in vivo, while Slamf8 negatively regulates ROS production and its absence accelerates myeloid cell migration; inhibiting ROS in Slamf8-deficient macrophages blocked enhanced in vitro migration. Knockout mice, in vivo migration assays (peritonitis, skin sensitization, intestinal repopulation), in vitro transwell migration assays, ROS production measurement with DPI inhibition PloS one High 25799045
2012 SLAMF1 (and related family members Ly108 and 2B4) regulate immunological synapse organization between cytotoxic lymphocytes and B cell targets; in the absence of SAP, signaling through Ly108 and 2B4 results in increased SHP-1 phosphatase recruitment, altered SHP-1 localization, and decreased activation of Src kinases at the synapse, leading to impaired actin clearance and defective killing of B cell targets. SAP-deficient mouse CD8+ T cells, cytotoxicity assays against different targets, confocal imaging of immunological synapses, phosphatase recruitment assays Immunity High 22683123
2017 SLAMF1 engagement by measles virus induces MeV endocytosis via a macropinocytosis-like pathway; MeV engagement of SLAMF1 triggers membrane blebbing, actin cytoskeleton rearrangement, and the RhoA-ROCK-myosin II signaling axis to mediate viral particle internalization; chemical inhibition of macropinocytosis or actin dynamics blocked MeV entry. Live-cell imaging, chemical inhibitors (RhoA-ROCK-myosin II pathway, macropinocytosis inhibitors), colocalization studies, infection assays in SLAMF1+ vs SLAMF1- cells Journal of virology High 28100610
2012 Slamf1 is required on myeloid cells for efficient intracellular replication of Trypanosoma cruzi; Slamf1-deficient mice were completely protected from lethal parasite challenge, with Slamf1-deficient myeloid cells impaired in parasite replication and showing altered cytokine production; anti-Slamf1 monoclonal antibody treatment also reduced cardiac parasites. Slamf1 knockout mice, in vivo and in vitro infection assays, anti-Slamf1 antibody blockade, cytokine production assays PLoS pathogens High 22807679
2020 Brucella abortus outer membrane protein Omp25 specifically binds SLAMF1 on dendritic cells; this Omp25-SLAMF1 engagement limits NF-κB translocation, decreases pro-inflammatory cytokine secretion, and impairs DC activation without affecting Brucella intracellular trafficking; at chronic infection stage, the Omp25-SLAMF1 axis is essential for bacterial persistence in vivo. In vitro binding assays (Omp25-SLAMF1 interaction), NF-κB translocation assays, cytokine measurement, mouse infection models (acute and chronic stages) Cellular microbiology High 31953913
2020 SLAMF1 is expressed on human neutrophils upon Mycobacterium tuberculosis stimulation; SLAMF1 colocalizes with LC3B+ vesicles, and SLAMF1 activation increases neutrophil autophagy induced by Mtb; tuberculosis patients' neutrophils display reduced SLAMF1 levels and lower autophagy against Mtb. Flow cytometry, confocal microscopy (SLAMF1-LC3B colocalization), SLAMF1 agonistic antibody stimulation, autophagy assays Autophagy Medium 32954947
2001 SLAMF1 (CD150) is downregulated from the cell surface after measles virus infection or contact with MV envelope proteins; anti-SLAM antibodies block virus binding but do not interfere with contact-mediated proliferation inhibition, demonstrating that MV-induced proliferation inhibition is independent of SLAMF1 and CD46 receptor engagement. Anti-SLAM antibody blocking assays, flow cytometric measurement of surface SLAM after infection/contact, cell proliferation assays Journal of virology Medium 11312320
2001 SLAMF1 (CD150) expression is induced on monocytes by phytohaemagglutinin, bacterial lipopolysaccharide, or measles virus itself (which do not constitutively express SLAM); once induced, SLAM serves as the functional MV receptor on activated monocytes, as confirmed by anti-SLAM antibody blocking of infection. Flow cytometry of monocyte SLAM expression under various stimuli, anti-SLAM antibody blocking of MV infection The Journal of general virology Medium 11714966
1997 SLAMF1 acts as a self-ligand (homophilic interaction) that promotes B cell proliferation and Ig synthesis; soluble SLAMF1 and L cells transfected with membrane SLAMF1 both enhanced proliferation and IgM, IgG, IgA production by activated human B cells, establishing SLAMF1-SLAMF1 homotypic interaction as a costimulatory signal for B cells. Recombinant soluble SLAMF1, SLAMF1-transfected L cells, B cell proliferation assays, Ig production measurement by ELISA The Journal of experimental medicine Medium 9091591
2015 SLAMF1, SLAMF5, and SLAMF6 act as negative regulators of humoral immune responses; combined knockout of all three genes resulted in enhanced T-dependent and T-independent antibody responses, with B-cell-intrinsic effects being more pronounced than T-cell effects as established by adoptive co-transfer experiments. Single and triple knockout mice, adoptive co-transfer of B and T cells, T-dependent and T-independent antibody response assays Frontiers in immunology Medium 25926831
2001 SLAMF1 engagement promotes T cell-mediated cytotoxicity; in CD4+ and CD8+ T cells SLAM enhanced TCR-mediated killing, and in Herpesvirus saimiri-transformed T cells SLAM engagement alone triggered cytotoxicity requiring release of lytic granules, extracellular Ca2+, cytoskeletal rearrangements, and MEK1/2 signaling in a CD95-independent manner. Cytotoxicity assays, pharmacological inhibition (MEK1/2, Ca2+, cytoskeletal), granule release assays European journal of immunology Medium 11536173
2019 SLAM family receptors (SFRs), with SLAMF6 alone being sufficient, promote iNKT cell development by reducing TCR signal strength after positive selection, improving iNKT cell survival; this involves the SAP-Fyn complex and the phosphatase SHP-1; loss of SFRs upregulated PD-1 expression on iNKT cells as a compensatory mechanism. SFR-deficient mice (seven simultaneous SFR knockouts), SLAMF6 single rescue in SFR-deficient background, epistasis with SAP-Fyn and SHP-1, TCR signaling measurement Nature immunology High 30833791
2008 Impaired SLAMF1 (SLAM) homotypic interaction between iNKT cells and mature dendritic cells from NOD mice results in defective GATA-3 upregulation and reduced IL-4/IL-10 (NKT2) cytokine production; NOD mDC express significantly lower levels of SLAMF1 due to the Slamf1 genetic defect, impairing peripheral NKT2 polarization. Cross-strain iNKT-DC co-culture assays, GATA-3 expression analysis, cytokine production measurement, flow cytometric SLAM expression on NOD vs C57BL/6 DCs Journal of immunology Medium 18606638
2007 CD150 (SLAMF1) co-localizes with lipid rafts in specific membrane compartments on CD8+ T cells after activation; overexpression of CD150 enhanced cytotoxic activity and IFN-γ secretion in vitro and anti-tumor activity in vivo, while siRNA silencing of CD150 reduced effector functions. Lipid raft fractionation/co-localization, CD150 overexpression and siRNA knockdown, cytotoxicity assays, IFN-γ ELISpot, xenograft tumor model Molecular immunology Medium 17692919

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2449 15989959
2000 SLAM (CDw150) is a cellular receptor for measles virus. Nature 865 10972291
1998 The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 705 9774102
2011 SLAM family receptors and SAP adaptors in immunity. Annual review of immunology 404 21219180
2010 Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). Journal of immunology (Baltimore, Md. : 1950) 353 20525889
2007 Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 287 18031695
2018 SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis. Science (New York, N.Y.) 285 29622725
2001 Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors. Journal of virology 268 11390585
2003 SAP couples Fyn to SLAM immune receptors. Nature cell biology 249 12545174
2003 The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nature reviews. Immunology 233 14523387
2007 Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques. PLoS pathogens 213 18020706
2007 Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annual review of immunology 210 17201683
2001 Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nature immunology 205 11477403
2005 SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 199 16219798
2018 CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell stem cell 195 29456159
2003 Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells. Journal of virology 183 12941904
2002 SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein. Journal of virology 181 12050387
2003 The dual-function CD150 receptor subfamily: the viral attraction. Nature immunology 179 12496974
2006 Immune regulation by SLAM family receptors and SAP-related adaptors. Nature reviews. Immunology 177 16493427
2009 SLAM receptors and SAP influence lymphocyte interactions, development and function. Nature reviews. Immunology 175 19079134
2001 CD150 (SLAM) is a receptor for measles virus but is not involved in viral contact-mediated proliferation inhibition. Journal of virology 160 11312320
2001 CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus. Virology 150 11145884
1997 Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. The Journal of experimental medicine 137 9091591
2015 SLAM family receptors in normal immunity and immune pathologies. Current opinion in immunology 126 26682762
2010 SLAM-family receptors: immune regulators with or without SAP-family adaptors. Cold Spring Harbor perspectives in biology 118 20300214
2013 CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma. Critical reviews in oncology/hematology 100 23731618
2007 Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity 99 18031694
2018 Dissecting newly transcribed and old RNA using GRAND-SLAM. Bioinformatics (Oxford, England) 93 29949974
2012 Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity 93 22683123
2003 The SLAM family of immune-cell receptors. Current opinion in immunology 90 12787752
2003 SLAM: cross-species gene finding and alignment with a generalized pair hidden Markov model. Genome research 89 12618381
2009 Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). Journal of virology 86 20042501
2006 NK cell regulation by SLAM family receptors and SAP-related adapters. Immunological reviews 84 17100873
2002 Analysis of receptor (CD46, CD150) usage by measles virus. The Journal of general virology 78 12029158
2006 Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. Journal of immunology (Baltimore, Md. : 1950) 73 16365421
2018 The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseases. Autoimmunity reviews 71 29729453
2008 DC-SIGN and CD150 have distinct roles in transmission of measles virus from dendritic cells to T-lymphocytes. PLoS pathogens 71 18421379
2013 Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150. PloS one 70 23554862
2010 Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. Journal of virology 67 20071568
2007 Slamf1, the NKT cell control gene Nkt1. Journal of immunology (Baltimore, Md. : 1950) 64 17237411
2007 The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction. Immunity 64 18031696
2001 Induction of the measles virus receptor SLAM (CD150) on monocytes. The Journal of general virology 64 11714966
2004 Measles virus receptors: SLAM and CD46. Reviews in medical virology 63 15248250
2011 Measles virus glycoprotein-pseudotyped lentiviral vector-mediated gene transfer into quiescent lymphocytes requires binding to both SLAM and CD46 entry receptors. Journal of virology 62 21450813
2011 Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. Journal of immunology (Baltimore, Md. : 1950) 59 22184727
2009 Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150. Stem cells (Dayton, Ohio) 58 19593793
2010 Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus. Clinical and experimental immunology 57 20345977
2008 Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). The Journal of biological chemistry 57 18292085
2019 SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection. Nature immunology 56 30833791
2003 CD46- and CD150-independent endothelial cell infection with wild-type measles viruses. The Journal of general virology 55 12692284
2002 The morbillivirus receptor SLAM (CD150). Microbiology and immunology 54 12008921
2006 Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection. Journal of virology 52 17135325
2005 Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 51 16260741
2005 Wild-type Rinderpest virus uses SLAM (CD150) as its receptor. The Journal of general virology 50 15914854
2006 A signal adaptor SLAM-associated protein regulates spontaneous autoimmunity and Fas-dependent lymphoproliferation in MRL-Faslpr lupus mice. Journal of immunology (Baltimore, Md. : 1950) 48 16365433
2015 SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response. The Journal of clinical investigation 47 26619119
2017 The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype. Chemico-biological interactions 43 28693884
2016 The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity 43 27521267
2015 Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PloS one 39 25799045
2010 Identification of key residues in virulent canine distemper virus hemagglutinin that control CD150/SLAM-binding activity. Journal of virology 39 20631152
2001 Signaling lymphocytic activation molecule (SLAM) regulates T cellular cytotoxicity. European journal of immunology 39 11536173
2015 Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Frontiers in immunology 37 25926831
2006 High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice. Journal of virology 37 16775330
2017 The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis. Journal of virology 35 28100610
2010 The role of SLAM/CD2 polymorphisms in systemic autoimmunity. Current opinion in immunology 35 21094032
2008 Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950) 34 18606638
2018 SLAM-ITseq: sequencing cell type-specific transcriptomes without cell sorting. Development (Cambridge, England) 33 29945865
2012 Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells. Journal of immunology (Baltimore, Md. : 1950) 33 23225888
2004 The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. Blood 31 15315965
2006 The role of SAP and the SLAM family in autoimmunity. Current opinion in immunology 30 17011767
2006 SLAM family receptors and SAP-related adaptors: matters arising. Trends in immunology 29 16584920
2020 Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1. Autophagy 28 32954947
2010 The role of SAP and SLAM family molecules in the humoral immune response. Annals of the New York Academy of Sciences 28 21091715
2005 Fine-tuning of immune responses by SLAM-related receptors. Journal of leukocyte biology 27 16365151
2016 Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor. BMC veterinary research 26 27484638
2014 Fine specificity and molecular competition in SLAM family receptor signalling. PloS one 26 24642916
2012 The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi. PLoS pathogens 26 22807679
2002 The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150). Archives of virology 25 11855632
2002 Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. Immunogenetics 25 12242590
2018 SLAM family receptors in natural killer cells - Mediators of adhesion, activation and inhibition via cis and trans interactions. Clinical immunology (Orlando, Fla.) 24 30359773
2015 Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM. Journal of virology 24 26608324
2014 Role of SLAM family receptors and specific adapter SAP in innate-like lymphocytes. Critical reviews in immunology 24 24941157
2020 Omp25-dependent engagement of SLAMF1 by Brucella abortus in dendritic cells limits acute inflammation and favours bacterial persistence in vivo. Cellular microbiology 22 31953913
2018 SLAMF1/CD150 in hematologic malignancies: Silent marker or active player? Clinical immunology (Orlando, Fla.) 22 30616923
2007 Immunohistochemical demonstration of the putative canine distemper virus receptor CD150 in dogs with and without distemper. Veterinary pathology 22 18039911
2004 SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors. The Journal of experimental medicine 22 15123741
2019 NK cell recognition of hematopoietic cells by SLAM-SAP families. Cellular & molecular immunology 21 30911116
2011 Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential. Blood 21 21791413
2024 SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Developmental cell 20 38366599
2003 SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients. The Journal of biological chemistry 20 12766168
2020 SLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma. Scientific reports 19 32054954
2020 Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases. Frontiers in immunology 19 32983115
2019 Sequencing cell-type-specific transcriptomes with SLAM-ITseq. Nature protocols 19 31243395
2015 IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation. The Journal of biological chemistry 19 26060253
2011 A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. PloS one 19 22194822
2007 Characterization of mouse CD229 (Ly9), a leukocyte cell surface molecule of the CD150 (SLAM) family. Tissue antigens 19 17919264
2006 The role of SLAM family receptors in immune cell signaling. Biochemistry and cell biology = Biochimie et biologie cellulaire 19 17215871
2023 SLAM-Drop-seq reveals mRNA kinetic rates throughout the cell cycle. Molecular systems biology 18 38778223
2019 Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species. Viruses 18 31430904
2007 Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP. Molecular immunology 18 17692919