Affinage

SERPINA3

Alpha-1-antichymotrypsin · UniProt P01011

Length
423 aa
Mass
47.7 kDa
Annotated
2026-04-28
100 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SERPINA3 (alpha-1-antichymotrypsin) is a secreted serine protease inhibitor that functions as an acute-phase protein, inhibiting cathepsin G and related proteases, and participates in diverse processes including hematopoietic progenitor mobilization, inflammation, cortical development, and cancer progression (PMID:17485262, PMID:15795238). Its transcription is directly regulated by the orphan nuclear receptor Nur77 via an NBRE element in the promoter, by NR4A1/NR1D1 in response to ApoA4 signaling in hepatocytes, and by STAT3 in melanoma cells (PMID:18248459, PMID:28412351, PMID:31278347). In multiple cancer types, SERPINA3 promotes cell proliferation, migration, invasion, and epithelial-mesenchymal transition through MAPK/ERK, PI3K/AKT, NF-κB, and EZH2-dependent mechanisms, and facilitates metastasis partly by upregulating MMP-2/9 (PMID:24817931, PMID:29855767, PMID:33569740, PMID:37417362). In the developing brain, SERPINA3 overexpression drives outer radial glia proliferation and neocortical gyrification by binding the Glo1 promoter (PMID:36414636).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2005 Medium

    Establishing that SERPINA3 is not merely a hepatic acute-phase protein but is expressed by bone marrow hematopoietic cells and dynamically down-regulated during progenitor mobilization, linking protease–antiprotease balance to stem cell release.

    Evidence ELISA and RT-PCR of bone marrow during G-CSF- or chemotherapy-induced mobilization in human subjects

    PMID:15795238

    Open questions at the time
    • No direct demonstration that SERPINA3 loss is required or sufficient for progenitor egress
    • Identity of the specific serine protease(s) counterbalanced by SERPINA3 in this context not established
    • Mechanism of SERPINA3 down-regulation during mobilization unknown
  2. 2008 High

    Identifying the first direct transcriptional regulator of SERPINA3: the orphan nuclear receptor Nur77 binds an NBRE element at −182 to −175 in the SERPINA3 promoter, explaining how nuclear receptor signaling controls acute-phase SERPINA3 expression.

    Evidence EMSA, ChIP, luciferase reporter, Nur77 overexpression and RNAi in human cell lines

    PMID:18248459

    Open questions at the time
    • Physiological stimuli upstream of Nur77 that regulate SERPINA3 in vivo not defined
    • Contribution of Nur77 versus other transcription factors to hepatic SERPINA3 expression not quantified
  3. 2014 Medium

    Demonstrating that SERPINA3 has a cell-autonomous pro-proliferative role in cancer, promoting G2/M progression and inhibiting apoptosis via MAPK/ERK1/2 and PI3K/AKT signaling — shifting understanding from a secreted protease inhibitor to an intracellular signaling modulator.

    Evidence SERPINA3 overexpression/knockdown in endometrial cancer cells with cell cycle, apoptosis, and phospho-western blot readouts

    PMID:24817931

    Open questions at the time
    • Direct binding partners mediating MAPK/ERK and PI3K/AKT activation not identified
    • Whether the protease inhibitory activity is required for the proliferative phenotype is unknown
    • Findings limited to a single cancer type at this point
  4. 2017 Medium

    Extending SERPINA3's oncogenic role to melanoma (pro-migration/invasion without affecting proliferation) and showing that ApoA4-NR4A1/NR1D1 signaling constitutes a second nuclear-receptor-dependent transcriptional axis for SERPINA3 in hepatocytes, broadening understanding of its regulation.

    Evidence siRNA knockdown with migration/invasion assays in melanoma (PMID:27213583); ChIP, luciferase, and RNAi for NR4A1/NR1D1 in mouse hepatocytes (PMID:28412351)

    PMID:27213583 PMID:28412351

    Open questions at the time
    • The cell-type-specific effects (proliferation vs. migration) are unexplained mechanistically
    • Whether NR4A1/NR1D1-mediated regulation occurs in extrahepatic tissues is untested
  5. 2018 Medium

    Providing in vivo evidence that SERPINA3 promotes cancer metastasis: silencing SERPINA3 reduces colon cancer liver metastasis in a mouse xenograft model, mechanistically linked to decreased MMP-2/9 expression.

    Evidence siRNA knockdown, Transwell invasion assay, ELISA for MMP-2/9, mouse liver metastasis model with IHC

    PMID:29855767

    Open questions at the time
    • Whether MMP-2/9 regulation by SERPINA3 is direct or indirect remains unresolved
    • Role of SERPINA3's protease inhibitory function versus a non-canonical activity in metastasis is unclear
  6. 2019 High

    Identifying STAT3 as a third direct transcriptional regulator of SERPINA3, binding defined sites in the SERPINA3 promoter in melanoma cells and coupling SERPINA3 expression to STAT3-driven migration and invasion.

    Evidence STAT3 siRNA knockdown, ChIP-qPCR for STAT3 at SERPINA3 promoter, migration and invasion assays in melanoma cells

    PMID:31278347

    Open questions at the time
    • Whether STAT3 regulation of SERPINA3 generalizes beyond melanoma is unknown
    • Epistatic relationship between Nur77 and STAT3 at the SERPINA3 promoter not addressed
  7. 2021 Medium

    Broadening SERPINA3's downstream signaling repertoire: in breast cancer SERPINA3 drives EMT through EZH2 upregulation and reduces cisplatin sensitivity; in vascular smooth muscle cells it promotes proliferation and migration via NF-κB/IκBα phosphorylation; and circSERPINA3 stabilizes SERPINA3 mRNA through BUD13 recruitment and miR-653-5p sponging.

    Evidence Overexpression/knockdown with EMT marker and EZH2 western blot in TNBC (PMID:33569740); siRNA in RASMCs with NF-κB western blot (PMID:34957248); RIP, RNA pulldown, luciferase reporter for circSERPINA3/BUD13/miR-653-5p axis in prostate cancer (PMID:34861864)

    PMID:33569740 PMID:34861864 PMID:34957248

    Open questions at the time
    • Whether EZH2 is a direct or indirect target of SERPINA3 is unknown
    • The NF-κB effects of SERPINA3 differ in direction across cancer vs. vascular contexts — mechanistic basis unresolved
    • All findings from single labs without independent replication
  8. 2022 Medium

    Revealing a neurodevelopmental role: human SERPINA3 overexpression in mouse brain induces cortical folding by promoting outer radial glia proliferation, with SERPINA3 directly binding the Glo1 promoter as a transcriptional mechanism — an unexpected non-canonical function for a serpin.

    Evidence In vivo SERPINA3 overexpression in mouse brain, ChIP for SERPINA3 at Glo1 promoter, histological and behavioral analysis

    PMID:36414636

    Open questions at the time
    • How a secreted protease inhibitor enters the nucleus and acts as a transcriptional regulator is mechanistically unexplained
    • Whether endogenous SERPINA3 is required for human cortical gyrification is untested
    • Glo1 downstream effectors mediating oRG proliferation not identified
  9. 2022 Medium

    Demonstrating that SERPINA3 modulates NF-κB-dependent inflammation in osteoarthritis chondrocytes, suppressing COX2, iNOS, TNF-α, IL-6, and MMPs — consistent with its anti-inflammatory function via protease inhibition in non-cancer contexts.

    Evidence siRNA and pharmacological modulation in IL-1β-stimulated chondrocytes with NF-κB western blot; rat OA model

    PMID:36056701

    Open questions at the time
    • Whether chondroprotective effects require serine protease inhibitory activity specifically is not tested
    • Findings from a single lab; effect size of SERPINA3 relative to other serpins in OA unknown
  10. 2023 Medium

    In lung cancer, SERPINA3 overexpression upregulates SPOP and suppresses NF-κB p65, inhibiting tumor growth — revealing context-dependent tumor-suppressive activity contrasting with its oncogenic role in other cancers.

    Evidence DIA-MS proteomics, western blot validation, xenograft mouse model with SERPINA3 overexpression in lung cancer cells

    PMID:37417362

    Open questions at the time
    • Why SERPINA3 is tumor-suppressive in lung cancer but oncogenic in other cancers is mechanistically unexplained
    • Whether SERPINA3 directly regulates SPOP expression or acts indirectly is not established
    • Single study; independent replication lacking

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions remain: (1) how a secreted serpin accesses the nucleus to regulate promoters (Glo1), (2) what determines the context-dependent pro- vs. anti-tumorigenic activity across cancer types, and (3) whether the protease-inhibitory and signaling functions are mechanistically separable.
  • No nuclear import mechanism or nuclear localization signal identified for SERPINA3
  • Structure–function dissection separating protease inhibition from intracellular signaling not performed
  • No crystal structure of SERPINA3 bound to a non-protease partner

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0140110 transcription regulator activity 1
Localization
GO:0005576 extracellular region 3
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 2
Partners
BUD13EZH2GLO1NR1D1NR4A1SPOPSTAT3

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 SERPINA3 (alpha-1-antichymotrypsin/ACT) functions as a serine protease inhibitor; its structure, regulatory elements, tissue-specific expression, and physiological roles including acute-phase response were characterized. It inhibits cathepsin G and other serine proteases. Review synthesizing proteomic, transcriptomic, and genomic studies Frontiers in bioscience Medium 17485262
2005 SERPINA3 (serpina3) is expressed by multiple hematopoietic cell populations in bone marrow and is down-regulated at both mRNA and protein levels during G-CSF- or chemotherapy-induced hematopoietic progenitor mobilization, shifting the balance between serine protease inhibitors and neutrophil serine proteases to allow progenitor release. Protein and mRNA expression analysis (ELISA, RT-PCR) in bone marrow during mobilization; tissue comparison (bone marrow vs. liver) The Journal of experimental medicine Medium 15795238
2008 Orphan nuclear receptor Nur77 directly binds to the NBRE element (-182 to -175) in the SERPINA3 promoter, transactivating SERPINA3 gene expression, as demonstrated by EMSA, ChIP, luciferase reporter assays, Nur77 overexpression, and RNA interference-mediated knockdown. Luciferase reporter assay, EMSA, chromatin immunoprecipitation (ChIP), Nur77 overexpression, RNA interference knockdown The FEBS journal High 18248459
2017 ApoA4 stimulates SERPINA3 gene expression in mouse hepatocytes in a dose- and time-dependent manner; the transcriptional response is mediated by ApoA4 binding to nuclear receptors NR4A1 and NR1D1 on the SERPINA3 promoter, as confirmed by ChIP, luciferase assay, and RNA interference of NR4A1 or NR1D1. ChIP, luciferase reporter assay, RNA interference, RT-PCR, in vivo and in vitro hepatocyte stimulation Biochemical and biophysical research communications High 28412351
2019 STAT3 directly regulates SERPINA3 transcription in human melanoma cells; STAT3 knockdown reduces SERPINA3 expression, and STAT3 physically associates with defined STAT3-binding sites in the SERPINA3 promoter as validated by ChIP-qPCR. SERPINA3 is functionally involved in STAT3-mediated regulation of melanoma migration and invasion. Gene expression profiling, STAT3 siRNA knockdown, chromatin immunoprecipitation (ChIP)-qPCR, migration and invasion assays Laboratory investigation High 31278347
2014 SERPINA3 promotes endometrial cancer cell proliferation by regulating G2/M cell cycle checkpoint and inhibiting apoptosis; this pro-proliferative effect is mediated through activation of MAPK/ERK1/2 and PI3K/AKT signaling pathways. SERPINA3 overexpression/knockdown, cell cycle analysis, apoptosis assay, western blot for ERK1/2 and AKT phosphorylation International journal of clinical and experimental pathology Medium 24817931
2018 SERPINA3 silencing inhibits the migration, invasion, and liver metastasis of colon cancer cells, and reduces MMP-2 and MMP-9 expression levels both in vitro (ELISA) and in vivo (immunohistochemistry in mouse liver metastasis model). siRNA knockdown, wound-healing assay, Transwell invasion assay, ELISA (MMP-2/9), mouse xenograft liver metastasis model, immunohistochemistry Digestive diseases and sciences Medium 29855767
2017 SERPINA3 knockdown significantly decreases migration and matrix invasion of melanoma cells without affecting proliferation, establishing a pro-migration and pro-invasion function for SERPINA3 in melanoma. siRNA knockdown, cell migration assay, matrix invasion assay, cell proliferation assay Oncotarget Medium 27213583
2021 SERPINA3 overexpression in triple-negative breast cancer cells promotes cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) by upregulating EMT markers and EZH2; SERPINA3 overexpression also reduces sensitivity to cisplatin. Overexpression and knockdown, wound healing, Transwell assay, CCK-8 proliferation assay, western blot for EMT markers and EZH2, drug sensitivity assay Breast cancer (Tokyo, Japan) Medium 33569740
2021 SERPINA3 regulates vascular smooth muscle cell (VSMC) proliferation and migration through the NF-κB signaling pathway; SERPINA3 knockdown in rat aortic smooth muscle cells attenuated proliferation, migration, and inhibited phosphorylated IκBα and its downstream pathway. Secreted SERPINA3 protein increases inflammatory factor expression in human umbilical vein endothelial cells (HUVECs). siRNA knockdown in RASMCs, EdU proliferation assay, scratch migration assay, western blot and RT-PCR for NF-κB pathway components, SERPINA3 protein stimulation of HUVECs Frontiers in cardiovascular medicine Medium 34957248
2021 CircSERPINA3 stabilizes SERPINA3 mRNA by recruiting the RNA-binding protein BUD13, and also acts as a miR-653-5p sponge to competitively release SERPINA3 from miR-653-5p-mediated suppression. SERPINA3 itself inhibits apoptosis and promotes aerobic glycolysis and autophagy in prostate cancer cells. RT-qPCR, RNA pulldown, luciferase reporter assay (miRNA sponge), RIP (RNA immunoprecipitation), functional assays (apoptosis, autophagy, glycolysis) Journal of translational medicine Medium 34861864
2023 SERPINA3 overexpression in lung cancer cells upregulates SPOP and inhibits NF-κB p65, suppressing tumor cell growth, proliferation, migration, and invasion; mechanistically identified by data-independent acquisition mass spectrometry (DIA-MS) and validated by western blot in cell lines and mouse xenograft tumors. SERPINA3 overexpression, DIA-MS proteomics, western blot, xenograft mouse model, proliferation and invasion assays International journal of oncology Medium 37417362
2022 Human SERPINA3 overexpression in mice induces neocortical folding and increases outer radial glia (oRG) proliferation and upper-layer neuron numbers; SERPINA3 promotes oRG proliferation by binding to the Glo1 promoter, with Glo1 identified as a downstream target involved in SERPINA3-induced gyrification. SERPINA3 overexpression in mouse brain, ChIP (SERPINA3 binding to Glo1 promoter), histological analysis, behavioral cognitive testing Cell discovery Medium 36414636
2022 SERPINA3 inhibits NF-κB activation and downstream inflammatory mediators (COX2, iNOS, TNF-α, IL-6, MMP13, MMP9) in osteoarthritis chondrocytes; sinensetin exerts its chondroprotective effects partly by regulating SERPINA3 expression. In vitro IL-1β-stimulated OA chondrocytes, siRNA/pharmacological modulation of SERPINA3, western blot for NF-κB and inflammatory markers, rat OA in vivo model Food & function Medium 36056701
2017 SERPINA3 is strongly up-regulated at both mRNA and protein levels in the brain of all human prion disease subtypes, suggesting involvement in prion disease pathogenesis and progression; this is distinct from the mild up-regulation observed in Alzheimer's disease. RT-qPCR on frontal cortex samples (128 prion disease patients, 14 AD patients, 30 controls), protein-level confirmation Scientific reports Low 29142239
2022 SERPINA3 is upregulated in renal tubules of diabetic nephropathy patients; as an inhibitor of mast cell chymase, SERPINA3 is proposed to protect against renal tubular injury by inhibiting mast cell proliferation/activation and chymase activity. RNA-seq dataset analysis, immunohistochemistry of human renal tubular biopsies for SERPINA3 and chymase expression, mast cell infiltration analysis Frontiers in immunology Low 36304455

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 RNA editing by adenosine deaminases that act on RNA. Annual review of biochemistry 1058 12045112
2018 Circular RNAs Act as miRNA Sponges. Advances in experimental medicine and biology 908 30259358
2021 Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 501 33606976
1988 Aromatic rings act as hydrogen bond acceptors. Journal of molecular biology 496 3172202
2008 Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database. Bioinformatics (Oxford, England) 493 18845581
2020 Metabolites released from apoptotic cells act as tissue messengers. Nature 405 32238926
2015 Alternative 3' UTRs act as scaffolds to regulate membrane protein localization. Nature 384 25896326
2016 Mitochondrial biogenesis and clearance: a balancing act. The FEBS journal 371 27462821
2019 Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons. Cell 329 30612743
2018 A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation. Trends in microbiology 249 30201512
1990 Novel anxiolytics that act as partial agonists at benzodiazepine receptors. Trends in pharmacological sciences 240 1980040
2006 KIF14 and citron kinase act together to promote efficient cytokinesis. The Journal of cell biology 231 16431929
2000 p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nature cell biology 231 10707085
2013 The molecular balancing act of p16(INK4a) in cancer and aging. Molecular cancer research : MCR 228 24136988
2012 Intragenic enhancers act as alternative promoters. Molecular cell 219 22264824
2019 FACT caught in the act of manipulating the nucleosome. Nature 179 31775157
2007 Myosin II and mechanotransduction: a balancing act. Trends in cell biology 179 17320396
2001 Hematopoietic development: a balancing act. Current opinion in genetics & development 163 11532392
2010 Molecular diversity through RNA editing: a balancing act. Trends in genetics : TIG 154 20395010
1994 A class act: conservation of homeodomain protein functions. Development (Cambridge, England) 151 7579525
2000 Cholecystokinin and leptin act synergistically to reduce body weight. American journal of physiology. Regulatory, integrative and comparative physiology 139 10749775
2019 NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Developmental cell 124 30982665
2007 SERPINA3 (aka alpha-1-antichymotrypsin). Frontiers in bioscience : a journal and virtual library 123 17485262
2009 Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. Nature structural & molecular biology 120 20037596
2003 Integrins in angiogenesis: multitalented molecules in a balancing act. Cell and tissue research 117 13680353
2011 Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction. Autophagy 116 22024743
2012 Antidepressants act directly on astrocytes: evidences and functional consequences. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 106 22609317
2008 Myosin V and Kinesin act as tethers to enhance each others' processivity. Proceedings of the National Academy of Sciences of the United States of America 104 18347333
2003 pannier and pointedP2 act sequentially to regulate Drosophila heart development. Development (Cambridge, England) 104 12756183
2018 The Chromatin Remodelers PKL and PIE1 Act in an Epigenetic Pathway That Determines H3K27me3 Homeostasis in Arabidopsis. The Plant cell 103 29802212
2020 Manumycin polyketides act as molecular glues between UBR7 and P53. Nature chemical biology 100 32572277
2013 The balancing act of DNA repeat expansions. Current opinion in genetics & development 98 23725800
2005 Chutes and Ladders: the search for protein kinases that act on AMPK. Trends in biochemical sciences 95 16356723
2005 Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. The Journal of experimental medicine 87 15795238
2002 Sieve elements caught in the act. Trends in plant science 86 11906836
2002 Sex steroid hormones act as growth factors. The Journal of steroid biochemistry and molecular biology 82 12650699
2018 Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling. The Journal of biological chemistry 77 30266805
2024 Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair. Nature 75 38926576
2005 Haemostasis in normal pregnancy: a balancing act? Biochemical Society transactions 74 15787621
2013 ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. PLoS genetics 70 23468649
2020 The balancing act: Immunology of leishmaniosis. Research in veterinary science 66 32109759
2020 Granulocytes act as a niche for Mycobacterium tuberculosis growth. Mucosal immunology 65 32483198
2016 The Balancing Act of Ribonucleotides in DNA. Trends in biochemical sciences 64 26996833
1990 Transcriptional enhancers can act in trans. Trends in genetics : TIG 63 2238088
2015 Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines. Cell death discovery 62 27551472
2023 Annotation of cell types (ACT): a convenient web server for cell type annotation. Genome medicine 61 37924118
2023 SERPINA3: Stimulator or Inhibitor of Pathological Changes. Biomedicines 59 36672665
2020 A balancing act: how plants integrate nitrogen and water signals. Journal of experimental botany 59 31990028
2014 Balancing act: matching growth with environment by the TOR signalling pathway. Journal of experimental botany 59 24567496
2015 AIL and HDG proteins act antagonistically to control cell proliferation. Development (Cambridge, England) 51 25564655
2015 Granting immunity to FOP and catching heterotopic ossification in the Act. Seminars in cell & developmental biology 51 26706149
2008 Elevated expression of SerpinA1 and SerpinA3 in HLA-positive cervical carcinoma. The Journal of pathology 51 18438953
1996 Polymorphism in AACT gene may lower age of onset of Alzheimer's disease. Neuroreport 50 8730823
2018 SERPINA3 Silencing Inhibits the Migration, Invasion, and Liver Metastasis of Colon Cancer Cells. Digestive diseases and sciences 48 29855767
2017 Up-regulation of SERPINA3 correlates with high mortality of melanoma patients and increased migration and invasion of cancer cells. Oncotarget 46 27213583
2019 Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila. PLoS genetics 43 30677014
2017 Differential overexpression of SERPINA3 in human prion diseases. Scientific reports 43 29142239
2000 Maximizing RNA folding rates: a balancing act. RNA (New York, N.Y.) 43 10864039
2021 Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial-mesenchymal-transition in triple-negative breast cancer cells. Breast cancer (Tokyo, Japan) 42 33569740
2014 SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. International journal of clinical and experimental pathology 41 24817931
2002 Telomeres act autonomously in maize to organize the meiotic bouquet from a semipolarized chromosome orientation. The Journal of cell biology 40 11956226
2017 Adenosine Deaminases That Act on RNA (ADARs). The Enzymes 39 28601223
2013 EMBRYONIC FLOWER1 and ULTRAPETALA1 Act Antagonistically on Arabidopsis Development and Stress Response. Plant physiology 39 23632855
2012 Do vacuolar peroxidases act as plant caretakers? Plant science : an international journal of experimental plant biology 35 23265317
2008 The disappearing act of factor VIII. Haemophilia : the official journal of the World Federation of Hemophilia 35 18771423
2024 New mechanism of LncRNA: In addition to act as a ceRNA. Non-coding RNA research 32 39022688
2019 Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo. Genes 32 31683575
2014 Mg2+ homeostasis: the balancing act of TRPM6. Current opinion in nephrology and hypertension 32 24906182
2011 Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas. Oncology letters 30 22866096
2019 Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells. Laboratory investigation; a journal of technical methods and pathology 28 31278347
2017 Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes. Biochemical and biophysical research communications 28 28412351
2012 Primary cilia act as mechanosensors during bone healing around an implant. Medical engineering & physics 28 22784673
2021 Optimizing pDNA Lipo-polyplexes: A Balancing Act between Stability and Cargo Release. Biomacromolecules 27 33616407
2016 FHY3 and FAR1 Act Downstream of Light Stable Phytochromes. Frontiers in plant science 27 26941752
2021 The Association and Pathogenesis of SERPINA3 in Coronary Artery Disease. Frontiers in cardiovascular medicine 26 34957248
2000 Hypermobility--not a circus act. International journal of clinical practice 26 10954958
2023 All-Inorganic Polyoxometalates Act as Superchaotropic Membrane Carriers. Advanced materials (Deerfield Beach, Fla.) 25 37943506
2022 Deiters Cells Act as Mechanical Equalizers for Outer Hair Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 25 36123119
2018 The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis. Skeletal muscle 25 30526691
2024 Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles. Neuropathology and applied neurobiology 24 38647003
2023 ZmSPL13 and ZmSPL29 act together to promote vegetative and reproductive transition in maize. The New phytologist 24 37306069
2019 DWT1/DWL2 act together with OsPIP5K1 to regulate plant uniform growth in rice. The New phytologist 23 31550392
2017 SERPINA3 induced by astroglia/microglia co-culture facilitates glioblastoma stem-like cell invasion. Oncology letters 23 29399139
2022 Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3. Food & function 22 36056701
2021 CircSERPINA3 regulates SERPINA3-mediated apoptosis, autophagy and aerobic glycolysis of prostate cancer cells by competitively binding to MiR-653-5p and recruiting BUD13. Journal of translational medicine 22 34861864
2008 Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77. The FEBS journal 22 18248459
2019 Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer. World journal of clinical cases 21 31423431
2016 7SKiing on chromatin: Move globally, act locally. RNA biology 20 27128603
2005 Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. Stroke 20 15718509
2016 Touch, act and go: landing and operating on nucleosomes. The EMBO journal 19 26787641
2024 Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis. Biomaterials 18 39471714
2021 Act Locally, Act Globally-Microbiota, Barriers, and Cytokines in Atherosclerosis. Cells 18 33562334
2021 Imatinib can act as an Allosteric Activator of Abl Kinase. Journal of molecular biology 17 34774565
2020 Exome sequencing identifies a recurrent variant in SERPINA3 associating with hereditary susceptibility to breast cancer. European journal of cancer (Oxford, England : 1990) 17 33279852
2016 APOBEC3G and APOBEC3F Act in Concert To Extinguish HIV-1 Replication. Journal of virology 17 26912618
2012 Cdc42p and Fus2p act together late in yeast cell fusion. Molecular biology of the cell 17 22323294
2022 Immune-related SERPINA3 as a biomarker involved in diabetic nephropathy renal tubular injury. Frontiers in immunology 16 36304455
2016 Adoptive Cellular Therapy (ACT) for Cancer Treatment. Advances in experimental medicine and biology 16 27240459
2023 Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer. International journal of oncology 15 37417362
2022 Human SERPINA3 induces neocortical folding and improves cognitive ability in mice. Cell discovery 15 36414636