Affinage

SEPTIN7

Septin-7 · UniProt Q16181

Audit flag: ungrounded claim
Length
437 aa
Mass
50.7 kDa
Annotated
2026-06-10
100 papers in source corpus 32 papers cited in narrative 32 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEPTIN7 is the central organizing subunit of mammalian hetero-oligomeric septin complexes and functions as a GTP-binding cytoskeletal scaffold that couples membrane and microtubule/actin dynamics to cell division, neuronal architecture, and Ca²⁺ signaling (PMID:15485874, PMID:31009756). From its earliest characterization as the yeast CDC3 ortholog forming the mother-bud neck filament ring, the protein has served as a structural constituent of septin filaments whose assembly and turnover are controlled by post-translational modification, including SUMO conjugation and cell-cycle-dependent CDK phosphorylation (PMID:1993729, PMID:10364461, PMID:12429908). In mammalian cells SEPT7 assembles into combinatorial filaments with partners such as SEPT2, SEPT9b, and SEPT11 along stress fibers, and its essential role in cytokinesis operates through microtubule destabilization: SEPT7 loss stabilizes/hyperacetylates microtubules and stalls midbody abscission, a defect rescued by the depolymerizing factor stathmin (PMID:15485874, PMID:25122120). This cytokinetic function is genetically separable from GTPase-domain-driven filament dimerization, which is dispensable for rescue of multinucleation (PMID:26818767). During mitosis SEPT7 directly binds the kinetochore motor CENP-E to ensure its kinetochore localization, chromosome alignment, and satisfaction of the spindle checkpoint, and organizes centrosomal microtubule nucleation by maintaining p150glued abundance (PMID:18460473, PMID:32869310). In the nervous system, SEPT7 localizes to the bases of dendritic branch points and spines and controls spine maturation: TAOK2 phosphorylates a conserved C-terminal residue (T426) to drive SEPT7 into spine heads where it stabilizes PSD95, an event protected from dephosphorylation by 14-3-3 gamma binding (PMID:17935997, PMID:28065648, PMID:35601601). SEPT7 acts as a negative regulator of Orai-channel-mediated Ca²⁺ entry through its membrane-phospholipid-binding N-terminal polybasic region, preventing premature STIM-Orai activation, and functions downstream of STIM1 in cerebellar circuit wiring (PMID:27225060, PMID:32682163, PMID:34993201). It additionally restrains vesicle trafficking and fusion—hindering GLUT4 storage vesicle docking by suppressing nonmuscle myosin IIA activity in the SNAP23 complex and modulating AP-3/ESCRT-dependent multivesicular body biogenesis—and is required for skeletal muscle development, sarcomere organization, and focal-adhesion-based mechanosensing (PMID:22809625, PMID:28011197, PMID:25380047, PMID:35929607, PMID:38695862, PMID:39650732).

Mechanistic history

Synthesis pass · year-by-year structured walk · 27 steps
  1. 1991 High

    Established the founding member of the septin family as a physical building block of a defined cytoskeletal structure, fixing the question of what septins are.

    Evidence Immunofluorescence of CDC3 fusion-protein antibodies across yeast genetic backgrounds localizing the protein to the mother-bud neck filament ring

    PMID:1993729

    Open questions at the time
    • Did not define the mammalian ortholog's composition or partners
    • No biochemical filament reconstitution
  2. 1999 Medium

    Showed septin ring dynamics are regulated by post-translational modification rather than being static, by demonstrating SUMO (Smt3) conjugation of Cdc3 and its requirement for ring integrity.

    Evidence Immunoprecipitation and immunofluorescence in a ubc9-1 SUMO-conjugation mutant

    PMID:10364461

    Open questions at the time
    • SUMO acceptor sites not mapped
    • Not extended to mammalian SEPT7
  3. 2002 Medium

    Identified cell-cycle kinase control of septin ring turnover by placing CDK1/Cdc28 phosphorylation of Cdc3 upstream of G1 ring disassembly.

    Evidence Phospho-site mutagenesis and septin-ring imaging in cln cyclin mutants

    PMID:12429908

    Open questions at the time
    • Mammalian relevance of these sites untested
    • Direct kinase-substrate biochemistry limited
  4. 2004 High

    Defined the mammalian SEPT7 oligomer by showing it co-purifies and directly binds SEPT2/8/9b/11 and that combinations dictate filament behavior, establishing SEPT7 as a combinatorial assembly hub.

    Evidence Anti-SEPT7 affinity purification, reciprocal co-IP, and co-expression imaging in rat fibroblasts and COS7 cells

    PMID:15485874

    Open questions at the time
    • Stoichiometry/architecture of native complexes not resolved
    • Functional output of each combination unclear
  5. 2007 High

    Extended SEPT7 function to neuronal morphogenesis, defining a SEPT5/7/11 complex required for dendritic branching and spine shape.

    Evidence Immunofluorescence, siRNA knockdown, and co-IP in hippocampal neurons

    PMID:17935997

    Open questions at the time
    • Molecular mechanism of spine control not defined at this stage
    • Upstream regulators unknown
  6. 2008 High

    Connected SEPT7 to chromosome segregation by showing it directly binds CENP-E and is required for kinetochore CENP-E localization and checkpoint satisfaction.

    Evidence GST pull-down, yeast two-hybrid, siRNA depletion with GFP-SEPT7 rescue in HeLa/MDCK cells

    PMID:18460473

    Open questions at the time
    • Binding interface not mapped
    • Whether monomeric SEPT7 or filaments engage CENP-E unclear
  7. 2012 High

    Revealed SEPT7 as a brake on vesicle trafficking, hindering GLUT4 storage vesicle delivery in podocytes via complexes with CD2AP/nephrin and VAMP2.

    Evidence Co-IP, siRNA and forchlorfenuron disruption, glucose uptake assays in podocytes

    PMID:22809625

    Open questions at the time
    • Direct vs scaffold role in vesicle docking not separated
    • Did not yet identify the myosin effector
  8. 2012 Medium

    Implicated SEPT7 in meiotic spindle regulation, showing both loss and excess disrupt microtubule organization and polar body extrusion.

    Evidence Immunofluorescence with siRNA knockdown and mRNA overexpression in mouse oocytes

    PMID:22895176

    Open questions at the time
    • Molecular target on the meiotic spindle unidentified
    • Single-system, single-lab
  9. 2013 Medium

    Showed SEPT7 participates in host-pathogen endocytosis through an actin-dependent N-cadherin complex recruited by C. albicans invasins.

    Evidence Affinity purification, siRNA, and cytochalasin D treatment with endocytosis readout in endothelial cells

    PMID:24345743

    Open questions at the time
    • Direct SEPT7-N-cadherin contact vs actin-mediated bridging unresolved
    • Generality beyond Candida unknown
  10. 2014 High

    Defined the mechanism of SEPT7's essential cytokinetic role as microtubule destabilization, with stathmin acting as the rescuing depolymerizer.

    Evidence Conditional SEPT7 knockout fibroblasts, live imaging, and stathmin supplementation rescue

    PMID:25122120

    Open questions at the time
    • How septins recruit/regulate stathmin not defined
    • Link to tubulin acetylation machinery unclear
  11. 2014 Medium

    Placed SEPT7 (with SEPT6) in endosomal cargo sorting by linking F-actin-bound septins to AP-3 and ESCRT-I membrane interactions.

    Evidence Co-IP, siRNA, and fluorescence microscopy of endosomal dynamics

    PMID:25380047

    Open questions at the time
    • Direct adapter contacts not mapped
    • Role of LRSAM1 ligase mechanistically thin
  12. 2016 High

    Established SEPT7 as a negative regulator ('molecular brake') of Orai-mediated Ca²⁺ entry with in vivo neural consequences.

    Evidence Bidirectional genetic manipulation in Drosophila neurons with Ca²⁺ imaging and flight assays

    PMID:27225060

    Open questions at the time
    • Domain responsible not yet localized in this study
    • Direct channel contact vs membrane organization unresolved
  13. 2016 Medium

    Identified the trafficking effector for the GLUT4 brake, showing SEPT7 suppresses NM-IIA (MYH9) activity within the SNAP23 complex.

    Evidence Co-IP, siRNA, myosin light-chain phosphorylation Western blots, glucose uptake in podocytes

    PMID:28011197

    Open questions at the time
    • How insulin lowers SEPT7 levels not defined
    • Direct vs indirect myosin inhibition unclear
  14. 2016 Medium

    Dissociated SEPT7's cytokinetic function from canonical GTPase-domain filament assembly, showing dimerization-defective mutants still rescue multinucleation.

    Evidence Doxycycline-inducible mutant rescue in SEPT7-null fibroblasts with biochemical GTPase characterization

    PMID:26818767

    Open questions at the time
    • What filament state is required remains unknown
    • Other domains' contribution untested
  15. 2017 High

    Defined the signaling input for spine maturation by identifying TAOK2 phosphorylation of a conserved SEPT7 C-terminal residue driving spine-head translocation and PSD95 stabilization.

    Evidence Chemical-genetic kinase labeling, mass spectrometry, phospho-mutagenesis, and imaging in neurons

    PMID:28065648

    Open questions at the time
    • How phosphorylation alters septin assembly mechanistically unclear
    • PSD95-binding interface not mapped
  16. 2018 Medium

    Uncovered an unexpected nuclear/transcriptional role, showing SEPT7 binds the CALB2 promoter and represses calretinin in mesothelioma.

    Evidence DNA-binding, ChIP, dual-luciferase, co-IP, and imaging in malignant mesothelioma cells

    PMID:29699512

    Open questions at the time
    • Direct vs cofactor-mediated DNA binding unresolved
    • Generality beyond mesothelioma unknown
  17. 2020 High

    Defined SEPT7's role in maintaining neural progenitor proliferation via KIF20A retention at the midbody, distinct from a frank cytokinesis defect.

    Evidence Co-IP, siRNA, and inducible NPC-specific Sept7 knockout with cortical phenotyping

    PMID:31813992

    Open questions at the time
    • Mechanism linking KIF20A displacement to differentiation unclear
    • Direct binding interface not mapped
  18. 2020 Medium

    Localized the Ca²⁺-braking activity to the N-terminal polybasic membrane-binding region and linked it to preventing premature STIM1-Orai1 assembly.

    Evidence siRNA, domain-deletion, and TIRF/confocal imaging of Orai1/STIM1 in human neural progenitors

    PMID:32682163

    Open questions at the time
    • Direct lipid/channel binding not biochemically reconstituted
    • How heteromers organize membrane phospholipids unclear
  19. 2020 Medium

    Positioned SEPT7 upstream of p150glued in centrosomal microtubule nucleation by showing SEPT7 maintains p150glued abundance.

    Evidence siRNA, co-IP, p150glued-overexpression rescue, and zebrafish embryo experiments

    PMID:32869310

    Open questions at the time
    • Mechanism by which SEPT7 stabilizes p150glued unknown
    • Direct vs indirect interaction unresolved
  20. 2021 Medium

    Identified PKA phosphorylation of SEPT7 at Thr197 as a switch disrupting SEPT7-SEPT7 interaction and primary cilium formation.

    Evidence Phospho-mutagenesis, co-IP, cAMP/PKA overexpression, and ciliogenesis imaging

    PMID:33572403

    Open questions at the time
    • Structural basis of selective SEPT7-SEPT7 disruption unclear
    • Cilia phenotype generality untested
  21. 2021 Medium

    Placed SEPT7 genetically downstream of STIM1 Ca²⁺ signaling in cerebellar circuit function via epistasis rescue of STIM1-knockout deficits.

    Evidence STIM1 and SEPT7 conditional knockout mice with gene expression, synapse morphology, and rotarod testing

    PMID:34993201

    Open questions at the time
    • Molecular link between STIM1 signaling and SEPT7 unclear
    • Cell-autonomy of the effect not fully resolved
  22. 2022 Medium

    Showed 14-3-3 gamma binds TAOK2-phosphorylated SEPT7 (T426) to protect it from dephosphorylation, completing a regulatory loop for spine maturation.

    Evidence Phosphopeptide pulldown, co-IP, imaging, and 14-3-3 antagonist expression in neurons

    PMID:35601601

    Open questions at the time
    • Phosphatase counteracting T426 not identified
    • Structural basis of protection unclear
  23. 2022 High

    Established SEPT7 as essential for skeletal muscle development, force generation, mitochondrial network organization, and regeneration.

    Evidence Conditional knockdown/knockout mice and C2C12 knockout with force, imaging, and differentiation assays

    PMID:35929607

    Open questions at the time
    • Molecular targets in mitochondrial/sarcomere organization not defined
    • Whether effects are cytokinesis-dependent unclear
  24. 2022 Medium

    Demonstrated cell-type-specific consequences of SEPT7 loss—cytokinesis defect in macrophages without functional impairment, and strong suppression of Kras-driven lung tumorigenesis.

    Evidence Lyz2-Cre and AT2-targeted SEPT7 knockout with phagocytosis, TNF, histopathology, and survival analysis

    PMID:35071236

    Open questions at the time
    • Mechanism of tumor suppression undefined
    • Whether tumor effect is proliferation-dependent unclear
  25. 2024 Medium

    Linked SEPT7 to sarcomere structural organization through a Numb interaction required for proper SEPT7 patterning in myofibers.

    Evidence Co-IP proteomics, immunofluorescence, and conditional Numb knockout mice

    PMID:38695862

    Open questions at the time
    • Direct binding interface unmapped
    • Whether Numb organizes or merely co-localizes with SEPT7 unclear
  26. 2024 Medium

    Defined integrin/ECM-controlled SEPT7 architectures at focal adhesions required for adhesion elongation, stabilization, and fibroblast mechanosensitivity.

    Evidence TIRF microscopy with siRNA and integrin-activation manipulation in fibroblasts

    PMID:39650732

    Open questions at the time
    • Molecular link between integrin activation and SEPT7 assembly unknown
    • Direct adhesion-complex partners not identified
  27. 2024 Medium

    Demonstrated that acute SEPT7 inhibition enhances immune cell motility and tumor infiltration, providing a causal handle on its restraining role in cell deformability.

    Evidence Optogenetic SEPT7-LOV2 inhibition with transmigration and spheroid infiltration assays in NK92 and CD8+ T cells

    PMID:39441641

    Open questions at the time
    • Molecular mechanism limiting protrusion not defined
    • Effect of chronic vs acute inhibition differs and unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SEPT7's many context-specific functions—cytokinesis, kinetochore/CENP-E binding, Ca²⁺ channel braking, vesicle trafficking, transcriptional repression, and neuronal scaffolding—are encoded by distinct filament states, partners, and phosphorylation marks remains unresolved.
  • No unified structural model linking nucleotide/assembly state to function
  • Direct binding interfaces for most partners unmapped
  • How upstream signals select among competing SEPT7 activities is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0008092 cytoskeletal protein binding 3 GO:0098772 molecular function regulator activity 3 GO:0003924 GTPase activity 2 GO:0008289 lipid binding 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1 GO:0005768 endosome 1 GO:0005815 microtubule organizing center 1 GO:0005929 cilium 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-112316 Neuronal System 3 R-HSA-162582 Signal Transduction 3 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-1266738 Developmental Biology 2
Partners
CENP-EKIF20AMYH9NUMBP150GLUEDPSD95SEPT11TAOK2
Complex memberships
CD2AP-nephrin complexSEPT2/7/9b/11 hetero-oligomeric septin complexSEPT5/7/11 neuronal septin complexSNAP23-NMHC-IIA complex

Evidence

Reading pass · 32 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 The CDC3 gene product (yeast ortholog of SEPT7) localizes to the ring of 10-nm filaments at the mother-bud neck in S. cerevisiae, as shown by immunofluorescence with antibodies generated against CDC3 fusion proteins. CDC3 protein assembles into a ring at the budding site before bud emergence and remains organized there after cytokinesis, establishing it as a structural constituent of septin filaments. Immunofluorescence with polyclonal antibodies raised against CDC3 fusion proteins in wild-type and mutant yeast cells The Journal of cell biology High 1993729
1999 The yeast SUMO-1 homolog Smt3 is conjugated to Cdc3 (yeast SEPT7 ortholog) at the mother-bud neck septin rings, as demonstrated by immunoprecipitation. Loss of Smt3 conjugation (in a ubc9-1 mutant) results in disappearance of septin rings and reduction of the Cdc3-Smt3 conjugate. The conjugate disappears around the time of cytokinesis, indicating SUMO modification of Cdc3 regulates septin ring dynamics. Immunoprecipitation, indirect immunofluorescence, genetic analysis using ubc9-1 mutant Biochemical and biophysical research communications Medium 10364461
2002 The yeast septin Cdc3 is phosphorylated near its C-terminus by the Cdc28 (CDK1) kinase in a cell-cycle-dependent manner. Mutation of the Cdc28-dependent phosphorylation sites impairs disassembly of the old septin ring inherited at mitosis; G1 cyclin function is required for efficient ring disassembly, placing CDK-mediated Cdc3 phosphorylation as a regulator of septin ring turnover at G1. Phospho-site mutagenesis, immunofluorescence analysis of septin ring dynamics in wild-type and cln mutants Cell cycle (Georgetown, Tex.) Medium 12429908
2004 Mammalian SEPT7 is a component of a septin complex with SEPT9b and SEPT11 in rat fibroblasts. Affinity purification with anti-SEPT7 antibody co-purified SEPT2, SEPT7, SEPT8, SEPT9b, and SEPT11. SEPT7, SEPT9b, and SEPT11 co-localize along stress fibers and directly bind each other through their N- or C-terminal divergent regions. Co-expression experiments in COS7 cells reveal combination-dependent filament elongation, bundling, or disruption. Anti-SEPT7 antibody affinity purification, immunoprecipitation, immunofluorescence, transient co-expression in COS7 cells The Journal of biological chemistry High 15485874
2007 SEPT7 localizes to the bases of filopodia and dendritic branch points in developing hippocampal neurons and to the bases of dendritic spines in mature neurons. Downregulation of SEPT7 impairs dendritic branching and causes elongated spine morphology. SEPT5 and SEPT11 co-localize with and co-immunoprecipitate with SEPT7, indicating existence of a SEPT5/7/11 complex in neurons. Immunofluorescence, siRNA knockdown, co-immunoprecipitation in hippocampal neurons Current biology : CB High 17935997
2008 SEPT7 directly interacts with the C-terminal domain of the kinetochore motor CENP-E, as demonstrated by GST pull-down and yeast two-hybrid assays. SEPT7 filaments distribute along the mitotic spindle and terminate at the kinetochore. siRNA-mediated depletion of SEPT7 abolishes kinetochore localization of CENP-E, reduces kinetochore tension, activates the spindle checkpoint (Mad2, BubR1), and causes chromosome mis-segregation; all phenotypes are rescued by exogenous GFP-SEPT7. GST pull-down, yeast two-hybrid, immunofluorescence, siRNA knockdown with rescue experiment in HeLa and MDCK cells The Journal of biological chemistry High 18460473
2012 SEPT7 forms a complex with CD2AP and nephrin in podocytes and co-immunoprecipitates with VAMP2. Filamentous localization of SEPT7 depends on CD2AP and intact actin organization. siRNA-mediated depletion of SEPT7 or pharmacological disruption of septin assembly with forchlorfenuron facilitates glucose uptake into podocytes and increases VAMP2 interaction with nephrin and syntaxin 4, indicating SEPT7 hinders GLUT4 storage vesicle (GSV) trafficking. Co-immunoprecipitation, siRNA knockdown, subcellular fractionation, immunofluorescence, 2-deoxy-D-glucose uptake assay in cultured podocytes Molecular biology of the cell High 22809625
2012 SEPT7 localizes to the meiotic spindle from pro-MI to MII stages in mouse oocytes. Knockdown of SEPT7 causes abnormal spindles and impairs extrusion of the first polar body. Overexpressed Myc-SEPT7 localizes to spindles and plasma membrane; overexpression weakens spindle α-tubulin fluorescence intensity and disrupts chromosome alignment and polar body extrusion, indicating SEPT7 regulates microtubule dynamics during meiosis. Immunofluorescence, siRNA microinjection knockdown, mRNA overexpression in mouse oocytes Cell cycle (Georgetown, Tex.) Medium 22895176
2014 Genetic deletion of SEPT7 in mouse fibroblasts causes multinucleation due to failure of cytokinesis, associated with hyperacetylation/stabilization of microtubules and stalled midbody abscission. Supplementation with the microtubule-depolymerizing protein stathmin rescues cytokinesis failure in SEPT7-null fibroblasts. Knockdown of stathmin sensitizes a hematopoietic cell line to the septin inhibitor forchlorfenuron, establishing that septin-dependent cytokinesis requires microtubule destabilization via stathmin. Conditional genetic knockout (SEPT7-floxed mice), live-cell imaging, stathmin supplementation rescue, siRNA knockdown, forchlorfenuron treatment PLoS genetics High 25122120
2014 SEPT6 and SEPT7 complexes bound to F-actin regulate multivesicular body (MVB) biogenesis by binding AP-3 (an endosomal adapter complex), modulating AP-3 membrane interactions and motility of AP-3-positive endosomes, and influencing ESCRT-I membrane interaction during cargo sorting. This coordination requires the E3 ubiquitin ligase LRSAM1. Co-immunoprecipitation, siRNA knockdown, fluorescence microscopy of endosomal dynamics PloS one Medium 25380047
2016 SEPT7 acts as a negative regulator ('molecular brake') of Orai channel-mediated Ca²⁺ entry in Drosophila neurons. Lowering SEPT7 levels results in store-independent dOrai-mediated Ca²⁺ entry and elevated cytosolic Ca²⁺ at rest. Overexpression of SEPT7 reduces both store-operated Ca²⁺ entry (SOCE) and flight duration in vivo, demonstrating that SEPT7 modulates Orai channel function and neural circuit activity. Genetic knockdown and overexpression in Drosophila neurons, Ca²⁺ imaging, in vivo flight assays Nature communications High 27225060
2016 SEPT7 forms a complex with nonmuscle myosin heavy chain IIA (NMHC-IIA/MYH9) and SNAP23. Insulin decreases SEPT7 levels and increases NM-IIA activity in the SNAP23 complex. Knockdown of SEPT7 increases NM-IIA activity (measured by myosin regulatory light chain phosphorylation) in the SNAP23 complex and thereby facilitates GLUT4 storage vesicle docking and fusion with the plasma membrane, indicating SEPT7 hinders GSV fusion by suppressing NM-IIA activity. Co-immunoprecipitation, siRNA knockdown, Western blot for myosin light chain phosphorylation, glucose uptake assay in podocytes Experimental cell research Medium 28011197
2016 GTPase domain-driven dimerization of SEPT7 is dispensable for its essential role in fibroblast cytokinesis. SEPT7 mutants with altered GTPase domain-dependent homo- or hetero-polymerization, GTP-binding, or GTPase activity can still rescue multinucleation in Sept7-null fibroblasts, indicating that well-defined native filament assembly via GTPase domain dimerization is not required for SEPT7's cytokinetic function. Conditional genetic knockout fibroblast system with doxycycline-inducible SEPT7 mutant rescue, biochemical analysis of GTPase mutants Scientific reports Medium 26818767
2017 The kinase TAOK2 directly phosphorylates SEPT7 at an evolutionarily conserved C-terminal residue (identified by chemical-genetics and mass spectrometry). This phosphorylation induces translocation of SEPT7 into the dendritic spine head, where SEPT7 associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine maturation and compartmentalization of NMDA receptor-mediated calcium influx. Chemical-genetic kinase labeling, mass spectrometry, phospho-site mutagenesis, live-cell imaging, co-immunoprecipitation in neurons Neuron High 28065648
2018 SEPT7 binds to the CALB2 (calretinin) gene promoter in a butyrate-dependent manner and acts as a transcriptional repressor of calretinin expression in malignant mesothelioma cells. Overexpression of SEPT7 decreases calretinin levels; conversely, calretinin overexpression decreases SEPT7 levels. SEPT7 and calretinin directly interact, as shown by co-immunoprecipitation, and co-localize in the cleavage furrow and midbody during cytokinesis. DNA-binding assays, peptide shotgun-mass spectrometry, dual-luciferase reporter assays, chromatin immunoprecipitation, lentiviral overexpression/knockdown, co-immunoprecipitation, immunofluorescence BMC cancer Medium 29699512
2019 High-resolution crystal structures of the SEPT7 GTPase domain complexed with GDP reveal coordination details of the magnesium ion and the molecular basis for interactions at the G-interface. A structural motif based on an antiparallel β-bridge at the G-interface rationalizes why SEPT7 (unlike some other septins) does not undergo nucleotide-dependent β-strand slippage, providing insight into filament assembly mechanisms. X-ray crystallography (two high-resolution structures of SEPT7 GTPase domain-GDP complex) Journal of structural biology High 31009756
2020 SEPT7 interacts with KIF20A in the intercellular bridge of dividing neural progenitor cells (NPCs). Knockdown of SEPT7 displaces KIF20A from the midbody and triggers precocious neuronal differentiation. NPC-specific inducible knockout of Sept7 causes early cell cycle exit, precocious neuronal differentiation, and ventriculomegaly without a noticeable cytokinesis defect, indicating SEPT7 maintains the proliferative state of NPCs through KIF20A-mediated mechanisms. Co-immunoprecipitation, immunofluorescence, siRNA knockdown, conditional inducible knockout mouse model, cortical phenotype analysis Cerebral cortex (New York, N.Y. : 1991) High 31813992
2020 SEPT7 prevents constitutive Ca²⁺ entry through Orai channels in human neural progenitor cells (hNPCs) and differentiated neurons. The N-terminal polybasic region of SEPT7, known to interact with membrane phospholipids, is essential for this inhibitory function (whereas the GTPase domain of dSEPT7 is dispensable). SEPT7 knockdown causes reorganization of Orai1 and STIM1 near the plasma membrane, supporting a model where SEPT7-containing heteromers prevent premature STIM-Orai complex activation. siRNA knockdown, Ca²⁺ imaging, domain-deletion analysis, TIRF/confocal microscopy of Orai1 and STIM1 localization in hNPCs Cell calcium Medium 32682163
2020 SEPT7 localizes to the centrosome, and depletion of SEPT7 causes aberrant mitotic spindle pole formation and disorganized microtubule nucleation. SEPT7 forms a complex with p150glued (a centriole subdistal appendage component), and SEPT7 depletion reduces the abundance of p150glued. Overexpression of p150glued reverses the microtubule nucleation defects caused by SEPT7 deficiency, placing SEPT7 upstream of p150glued in microtubule array organization. siRNA knockdown, co-immunoprecipitation, immunofluorescence, rescue by p150glued overexpression, zebrafish embryo experiments Journal of cellular physiology Medium 32869310
2021 Protein kinase A (PKA) phosphorylates SEPT7 at Thr197, disrupting septin filament dynamics and primary cilia formation. Treatment with cAMP or overexpression of PKA catalytic subunit induces SEPT7 Thr197 phosphorylation. Constitutive phosphorylation at Thr197 reduces SEPT7-SEPT7 interaction but does not affect SEPT7-SEPT6-SEPT2 or SEPT4 interaction. SEPT7 interacts with PKACA2 via its GTP-binding domain. Phospho-site mutagenesis, co-immunoprecipitation, cAMP/PKA overexpression, immunofluorescence of septin filaments and primary cilia Cells Medium 33572403
2021 Loss of SEPT7 in Purkinje neurons rescues motor coordination deficits and aberrant climbing fiber innervation caused by STIM1 knockout. Loss of SEPT7 (one or two copies) in STIM1-knockout Purkinje neurons restores expression of a subset of genes including neuron projection development genes and normalizes CF-PN innervation, establishing that SEPT7 acts downstream of STIM1-dependent Ca²⁺ signaling in cerebellar circuit function. Conditional knockout mouse models (STIM1 and SEPT7), gene expression analysis, synapse morphology, rotarod behavioral testing Frontiers in cell and developmental biology Medium 34993201
2022 14-3-3 proteins (specifically 14-3-3 gamma) interact with SEPT7 in a phosphorylation-dependent manner, specifically when SEPT7 is phosphorylated at T426 (the TAOK2 phosphorylation site). 14-3-3 gamma is enriched in mature dendritic spine heads. Expression of a 14-3-3 antagonist significantly decreases phospho-SEPT7 levels in neurons, indicating that 14-3-3 binding protects phosphorylated SEPT7 from dephosphorylation. Phosphopeptide pulldown, co-immunoprecipitation, immunofluorescence in neurons, 14-3-3 antagonist expression Frontiers in cell and developmental biology Medium 35601601
2022 Conditional knockdown of Septin7 in mice causes hunchback phenotype with skeletal deformities, reduced in vivo and in vitro muscle force, and disorganized mitochondrial networks. Knockout of Septin7 in C2C12 cells abolishes cell division. Knockdown in C2C12 cells impairs myotube differentiation. Septin7 expression transiently increases following muscle injury, suggesting a role in muscle regeneration and development. Conditional knockout/knockdown mouse model, C2C12 cell knockout, immunofluorescence, force measurement, confocal microscopy eLife High 35929607
2022 SEPT7 deletion in macrophages (via Lyz2-Cre) causes constitutive double-nucleation indicating a cytokinesis defect, but does not impair phagocytic function or LPS-stimulated TNF production. In AT2 cells, SEPT7 deletion dramatically suppresses oncogenic Kras-G12D-driven lung tumorigenesis, with control mice dying in 3-5 weeks while SEPT7-deficient animals survived 11+ weeks. Conditional genetic knockout (Lyz2-Cre × SEPT7-floxed), phagocytosis assay, TNF ELISA, histopathology, survival analysis Frontiers in cell and developmental biology Medium 35071236
2013 SEPT7 forms a complex with N-cadherin in endothelial cells, and this complex is recruited by C. albicans Als3 and Ssa1 invasins. N-cadherin acts as a link between SEPT7 and the fungus; knockdown of N-cadherin reduces SEPT7 recruitment. SEPT7 knockdown decreases N-cadherin accumulation around C. albicans and significantly inhibits endocytosis of the organism. Intact actin microfilaments are required for SEPT7-N-cadherin association. Confocal microscopy, affinity purification, siRNA knockdown, cytochalasin D actin depolymerization mBio Medium 24345743
2013 SEPT3 directly binds to SEPT5 and SEPT7 and forms a heteromeric complex at nerve terminals in mature neurons. In Sept3-null mice, expression of other septins including SEPT7 is unaltered, and SEPT3 is dispensable for normal neuronal development. Direct binding assay, co-immunoprecipitation, immunofluorescence in primary neurons, Sept3 knockout mouse analysis Journal of neurochemistry Medium 17564677
2024 SEPT7 interacts with Numb in C2C12 myotubes (identified by proteomics of Numb immunoprecipitates). Immunofluorescence reveals partial overlap of Numb and SEPT7 in myofibers. Conditional knockout of Numb causes disorganization of SEPT7 staining in myofibers, indicating Numb-SEPT7 interactions are critical for sarcomere structural organization. Co-immunoprecipitation proteomics, immunofluorescence, conditional knockout mouse model eLife Medium 38695862
2024 ECM-mediated integrin activation regulates spatially distinct SEPT7 structures at focal adhesions (FAs) in fibroblasts. In perinuclear regions, ECM binding stabilizes SEPT7 bundles at the back of FAs; in peripheral FAs, high integrin activation promotes elongation of SEPT7 structures. Ventral SEPT7 structures are required for FA elongation, stabilization, and fibroblast mechanosensitivity. Total internal reflection fluorescence (TIRF) microscopy, siRNA knockdown, integrin activation manipulation iScience Medium 39650732
2024 Blue light-induced inhibition of an engineered SEPT7-LOV2 hybrid protein in NK92 cells and CD8+ T cells induces extended cell protrusions and cell polarization, enhancing transmigration through confining spaces and improving penetration into tumor spheroids. This demonstrates that inhibiting SEPT7 function promotes immune cell infiltration by enhancing cell motility. Optogenetic protein engineering, live-cell imaging, transmigration assay, tumor spheroid infiltration assay Proceedings of the National Academy of Sciences of the United States of America Medium 39441641
2013 SEPT7 (via Sept7 variant 4) suppresses Bax-mediated apoptosis in yeast and also confers resistance to copper-mediated cell death in a caspase-independent manner. The yeast SEPT7 ortholog CDC10 similarly protects against copper toxicity and Bax expression. SEPT7 was unable to rescue the cell size increase of cdc10Δ yeast, indicating distinct functions for the anti-apoptotic versus cytoskeletal roles. Heterologous expression screen in yeast, cell viability assay, caspase-deficient (mca1Δ) strain analysis Biochimica et biophysica acta Low 24055994
2016 SEPT2 and SEPT7 depletion in MDA-MB-231 breast cancer cells inhibits migration and invasion, while overexpression enhances these behaviors. MEK/ERK activation is positively correlated with SEPT2 and SEPT7 protein levels, and MEK inhibitor U0126 normalizes increased invasiveness in SEPT7-overexpressing cells, placing SEPT7 upstream of MEK/ERK in regulating cancer cell invasion. siRNA knockdown, forced overexpression, Transwell migration/invasion assays, MEK inhibitor treatment, Western blot for MAPK signaling Oncotarget Low 27557506
2018 SEPT7 interacts with DOCK8 in primary equine lymphocytes, as identified by interaction proteomics. DOCK8 expression and its interaction network are significantly altered in equine recurrent uveitis (autoimmune disease), and ILK is identified as a DOCK8 interactor in lymphocytes. Interaction proteomics (immunoprecipitation-mass spectrometry), Western blot validation Scientific reports Low 30120291

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1991 Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site. The Journal of cell biology 291 1993729
1985 Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene. The EMBO journal 221 4018034
1992 Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+. Nature 215 1734281
1994 The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. The Journal of cell biology 208 8207058
2007 The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology. Current biology : CB 207 17935997
1994 cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. The EMBO journal 201 8313888
2004 Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. The Journal of biological chemistry 121 15485874
2017 TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron 113 28065648
1993 Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell 110 7916653
1999 Smt3, a SUMO-1 homolog, is conjugated to Cdc3, a component of septin rings at the mother-bud neck in budding yeast. Biochemical and biophysical research communications 91 10364461
1994 res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast. The EMBO journal 89 8168485
2014 Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS genetics 84 25122120
1980 Isolation of the centromere-linked CDC10 gene by complementation in yeast. Proceedings of the National Academy of Sciences of the United States of America 73 6990421
2008 Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. The Journal of biological chemistry 65 18460473
2013 MiR-30a-5p antisense oligonucleotide suppresses glioma cell growth by targeting SEPT7. PloS one 62 23383034
1995 Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10. The EMBO journal 62 7588609
2007 Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons. Journal of neurochemistry 58 17564677
1994 Hac1: a novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdc10 mutant of Schizosaccharomyces pombe. Nucleic acids research 58 7816617
2002 Phosphorylation of the septin cdc3 in g1 by the cdc28 kinase is essential for efficient septin ring disassembly. Cell cycle (Georgetown, Tex.) 57 12429908
1995 The SPR3 gene encodes a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilaments and is regulated by ABFI. Gene 57 7590307
2014 MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 54 24854842
1994 Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Biochemical and biophysical research communications 54 8037772
2016 The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation. Oncotarget 53 27557506
2012 Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking. Molecular biology of the cell 50 22809625
2016 Store-independent modulation of Ca(2+) entry through Orai by Septin 7. Nature communications 45 27225060
2011 Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. The Journal of biological chemistry 42 21937426
2013 Role of endothelial cell septin 7 in the endocytosis of Candida albicans. mBio 40 24345743
2009 Overexpression of septin 7 suppresses glioma cell growth. Journal of neuro-oncology 40 20035367
1992 Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe. Journal of cell science 39 1522142
2016 MiR-301a is activated by the Wnt/β-catenin pathway and promotes glioma cell invasion by suppressing SEPT7. Neuro-oncology 38 27006177
1989 Characterization of the fission yeast cdc10+ protein that is required for commitment to the cell cycle. Journal of cell science 38 2777915
2018 The role of septin 7 in physiology and pathological disease: A systematic review of current status. Journal of cellular and molecular medicine 37 29602250
1992 Mutations in the cdc10 start gene of Schizosaccharomyces pombe implicate the region of homology between cdc10 and SWI6 as important for p85cdc10 function. Molecular & general genetics : MGG 37 1406591
2014 MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7. Oncology reports 36 24604520
1999 Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription. Molecular biology of the cell 36 10564266
2004 Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+. Molecular biology of the cell 34 15385623
1992 A rat cerebellar protein containing the cdc10/SWI6 motif. European journal of biochemistry 34 1633812
1998 A novel protein containing Cdc10/SWI6 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes. The Journal of biological chemistry 32 9765218
2018 Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. BMC cancer 31 29699512
2016 Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion. Experimental cell research 30 28011197
2020 SEPT7 regulates Ca2+ entry through Orai channels in human neural progenitor cells and neurons. Cell calcium 28 32682163
1987 Mapping of the Saccharomyces cerevisiae CDC3, CDC25, and CDC42 genes to chromosome XII by chromosome blotting and tetrad analysis. Yeast (Chichester, England) 27 3332976
1994 Homologs of the yeast neck filament associated genes: isolation and sequence analysis of Candida albicans CDC3 and CDC10. Molecular & general genetics : MGG 26 8152419
2021 miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-κB pathway. Molecular therapy oncolytics 25 33614912
2016 GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Scientific reports 24 26818767
2013 The Coprinopsis cinerea septin Cc.Cdc3 is involved in stipe cell elongation. Fungal genetics and biology : FG & B 24 23973959
2012 Septin 7 is required for orderly meiosis in mouse oocytes. Cell cycle (Georgetown, Tex.) 24 22895176
2020 SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development. Cerebral cortex (New York, N.Y. : 1991) 23 31813992
2016 SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway. Oncology reports 23 26846171
2014 Unraveling the equine lymphocyte proteome: differential septin 7 expression associates with immune cells in equine recurrent uveitis. PloS one 23 24614191
1984 Septum pattern in ts mutants of Schizosaccharomyces pombe defective in genes cdc3, cdc4, cdc8 and cdc12. Journal of cell science 23 6490749
2014 Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis. PloS one 21 25380047
2022 Septin7 is indispensable for proper skeletal muscle architecture and function. eLife 19 35929607
2021 Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling. Development (Cambridge, England) 19 33472846
2020 Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued. Journal of cellular physiology 18 32869310
2010 Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Biochemical and biophysical research communications 18 20804727
2001 The role of DSC1 components cdc10+, rep1+ and rep2+ in MCB gene transcription at the mitotic G1-S boundary in fission yeast. Current genetics 18 11795845
2018 miR-590-3p mediates melatonin-induced cell apoptosis by targeting septin 7 in the human osteoblast cell line hFOB 1.19. Molecular medicine reports 17 29568931
2010 The expression pattern of SEPT7 correlates with sperm morphology. Journal of assisted reproduction and genetics 17 20352323
2020 MicroRNA-127-3p regulates myoblast proliferation by targeting Sept7. Biotechnology letters 16 32382971
2006 Role of the septin Cdc10 in the virulence of Candida albicans. Microbiology and immunology 14 16858141
2022 Proteomic Identification of Phosphorylation-Dependent Septin 7 Interactors that Drive Dendritic Spine Formation. Frontiers in cell and developmental biology 13 35602601
2019 Revisiting SEPT7 and the slippage of β-strands in the septin family. Journal of structural biology 13 31009756
2013 The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast. Biochimica et biophysica acta 13 24055994
1997 The Cdc2 protein kinase controls Cdc10/Sct1 complex formation. Molecular biology of the cell 13 9201719
1996 Murine central neurons express a novel member of the cdc10/SWI6 motif-containing protein superfamily. Brain research. Molecular brain research 13 8872304
2021 A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival. NPJ precision oncology 12 34002017
2018 Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity. Scientific reports 12 30120291
1998 Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start". Molecular biology of the cell 12 9614195
2010 Upregulation of SEPT7 gene inhibits invasion of human glioma cells. Cancer investigation 11 19916744
1996 Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. Cytogenetics and cell genetics 11 8697812
1993 Intragenic dominant suppressors of glp-1, a gene essential for cell-signaling in Caenorhabditis elegans, support a role for cdc10/SWI6/ankyrin motifs in GLP-1 function. Genetics 11 8307320
2021 Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis. Cells 9 33572403
2018 Septin 7 mediates high glucose-induced podocyte apoptosis. Biochemical and biophysical research communications 9 30361092
2022 Lyz2-Cre-Mediated Genetic Deletion of Septin7 Reveals a Role of Septins in Macrophage Cytokinesis and Kras-Driven Tumorigenesis. Frontiers in cell and developmental biology 8 35071236
2021 Deficits Associated With Loss of STIM1 in Purkinje Neurons Including Motor Coordination Can Be Rescued by Loss of Septin 7. Frontiers in cell and developmental biology 8 34993201
2020 Relationship between autophagy, apoptosis and endoplasmic reticulum stress induced by melatonin in osteoblasts by septin7 expression. Molecular medicine reports 8 32323792
2018 iTRAQ-based proteomic analysis of DMH-induced colorectal cancer in mice reveals the expressions of β-catenin, decorin, septin-7, and S100A10 expression in 53 cases of human hereditary polyposis colorectal cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 8 29956073
2016 Septin7 regulates inner ear formation at an early developmental stage. Developmental biology 8 27634570
1991 Sequence of the CDC10 region at chromosome III of Saccharomyces cerevisiae. Yeast (Chichester, England) 8 1872033
2024 Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids. Proceedings of the National Academy of Sciences of the United States of America 7 39441641
2023 Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration. International journal of molecular sciences 7 37686339
2018 Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress. Molecular medicine reports 7 29344665
2017 Genetic diversity of the Hwp1 gene and HIS3, EF3, CDC3 microsatellites and antifungal susceptibility profiles of Candida albicans isolates from Yaoundé HIV-infected patients. Medical mycology 7 27744307
2014 Septin 7 immunoexpression in papillary thyroid carcinoma: a preliminary study. Pathology, research and practice 7 24685401
2013 Septin 7: actin cross-organization is required for axonal association of Schwann cells. Biological research 7 24346071
2001 Characterization of the CDC10 product and the timing of events of the budding site of Saccharomyces cerevisiae. Molecules and cells 7 11561733
1997 Ran1 functions to control the Cdc10/Sct1 complex through Puc1. Molecular biology of the cell 7 9201720
2023 Simultaneous co-overexpression of Saccharomyces cerevisiae septins Cdc3 and Cdc10 drives pervasive, phospholipid-, and tag-dependent plasma membrane localization. Cytoskeleton (Hoboken, N.J.) 5 37098755
2021 A novel indel within the bovine SEPT7 gene is associated with ovary length. Animal biotechnology 5 34097585
2024 Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function. eLife 4 38695862
2024 ECM-dependent regulation of septin 7 in focal adhesions promotes mechanosensing and functional response in fibroblasts. iScience 4 39650732
2023 Effects of the CDC10 (Septin 7) Gene on the Proliferation and Differentiation of Bovine Intramuscular Preadipocyte and 3T3-L1 Cells. Animals : an open access journal from MDPI 4 36830396
2023 Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7. Cells 4 37508490
2012 Blastomyces dermatitidis septins CDC3, CDC10, and CDC12 impact the morphology of yeast and hyphae, but are not required for the phase transition. Medical mycology 4 22783804
2007 [Influence of SEPT7 on biological characters of glioma cell line TJ905]. Zhonghua wai ke za zhi [Chinese journal of surgery] 4 18241599
2024 Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca2+-PIK3CA pathway. iScience 3 39850355
2008 [Study on the anti-invasion effect of SEPT7 gene for U251MG glioma cell in vitro]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 3 18543212
1998 Sequence of murine CDC10 cDNA, gene organization and expression analysis. Biochimica et biophysica acta 3 9804986
2024 Quantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans. PloS one 2 39689097

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