Affinage

SEPTIN6

Septin-6 · UniProt Q14141

Length
434 aa
Mass
49.7 kDa
Annotated
2026-06-10
26 papers in source corpus 19 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 10/10 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEPTIN6 is a GTP-binding cytoskeletal protein that assembles into heteromeric septin filaments and serves as a membrane- and actin-associated scaffold supporting cytoarchitecture across diverse cell types (PMID:18047794, PMID:21544625). Within neurons, SEPT6 localizes to dendritic branch points and the bases of filopodia and spines as ring-like structures and is required for dendritic outgrowth and branching (PMID:21544625). It engages partner septins through interactions distinct from its coiled-coil domain, and these septin-septin contacts remodel SEPT6 filament organization (PMID:18047794). SEPT6 self-organization extends to liquid-liquid phase separation driven by weak multivalent interactions of its C-terminal tail, a property required to maintain adherens junction integrity and epithelial polarity (PMID:39973116). In membrane trafficking, F-actin-bound SEPT6/SEPT7 complexes bind the AP-3 adaptor and influence ESCRT-I membrane association, coordinating cargo sorting during multivesicular body biogenesis in an LRSAM1-dependent manner (PMID:25380047). SEPT6 has a non-redundant role in hematopoiesis, regulating long-term HSC function and lymphoid lineage choice (PMID:28751190), and in chromosomal segregation of myeloid progenitors, where a germline stop-loss mutation causes X-linked congenital neutropenia with myeloid tetraploidy (PMID:34677878). SEPT6 also contributes to host defense against intracellular bacteria (PMID:36855298) and is exploited by hepatitis C virus, binding the NS5b RNA-dependent RNA polymerase and hnRNP A1 to support viral RNA replication (PMID:17229681). Across epithelial cancers and fibrosis, SEPT6 acts upstream of pro-proliferative signaling, promoting F-actin formation to inhibit the Hippo pathway and drive YAP nuclear translocation (PMID:33846777) and activating TGF-β1/Smad signaling (PMID:30315255). SEPT6 expression is controlled post-transcriptionally by miR-223/AGO2 (PMID:29943706) and transcriptionally by LSD1-mediated promoter demethylation (PMID:33664458). SEPTIN6 is recurrently fused to MLL (KMT2A) in infant acute myeloid leukemia via t(X;11)(q24;q23) at a topoisomerase II cleavage site, generating an MLL-SEPT6 leukemogenic fusion protein (PMID:11809673, PMID:12096348, PMID:11477664, PMID:18492691).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2002 Medium

    Establishing how SEPTIN6 contributes to leukemia, this work showed it is recurrently fused to MLL in infant AML, producing a fusion protein incorporating nearly the entire septin sequence.

    Evidence RT-PCR, sequencing, cytogenetics and FISH across multiple infant AML cases

    PMID:11477664 PMID:11809673 PMID:12096348 PMID:18492691

    Open questions at the time
    • Does not define the biochemical activity of the MLL-SEPT6 fusion protein
    • Mechanism of leukemogenic transformation not resolved
  2. 2002 Medium

    Addressing why this specific translocation arises, the MLL breakpoint was shown to be a functional topoisomerase II cleavage site, implicating enzymatic DNA cleavage in generating the rearrangement.

    Evidence In vitro topoisomerase II cleavage assay with panhandle PCR and Southern blot

    PMID:12096348

    Open questions at the time
    • In vitro assay does not prove topoisomerase II generates the break in vivo
    • Single-lab characterization
  3. 2005 High

    Testing whether SEPT6 acts as a tumor suppressor or essential cytokinesis factor, knockout mice revealed extensive septin redundancy and no requirement for SEPT6 in normal development or MLL-SEPT6-driven disease.

    Evidence Sept6-deficient mice with bone marrow transplantation, retroviral MLL-SEPT6 expression, and Sept4-null epistasis

    PMID:16314519

    Open questions at the time
    • Redundancy obscures any SEPT6-specific function under unstressed conditions
    • Does not address tissue-specific or context-dependent roles
  4. 2007 Medium

    Connecting SEPT6 to viral pathogenesis, it was identified as an NS5b and hnRNP A1 interactor required for efficient HCV RNA replication.

    Evidence Yeast two-hybrid, co-immunoprecipitation, siRNA knockdown and dominant-negative overexpression

    PMID:17229681

    Open questions at the time
    • Molecular role of SEPT6 in the replication complex undefined
    • Single-lab finding
  5. 2007 Medium

    To understand how SEPT6 filaments are organized, SEPT12 was shown to bind SEPT6 independently of its coiled-coil and to remodel its filamentous structure, demonstrating septin-septin regulation of assembly.

    Evidence In vitro binding, co-IP, co-expression microscopy and deletion mapping in HeLa cells

    PMID:18047794

    Open questions at the time
    • Functional consequence of SEPT6-SEPT12 filaments not established
    • Stoichiometry within native septin complexes unknown
  6. 2011 Medium

    Defining a neuronal function, SEPT6 was localized to dendritic branch points and spine/filopodia bases and shown to be required for dendritic outgrowth and branching.

    Evidence Immunocytochemistry, fractionation and RNAi with morphological quantification in hippocampal neurons

    PMID:21544625

    Open questions at the time
    • Molecular mechanism linking septin rings to dendrite morphology unclear
    • Partners at branch points not identified
  7. 2014 Medium

    Linking SEPT6 to membrane trafficking, F-actin-bound SEPT6/SEPT7 complexes were shown to coordinate AP-3 and ESCRT-I machineries during MVB biogenesis.

    Evidence Reciprocal co-IP, siRNA knockdown, live-cell endosome imaging and fractionation

    PMID:25380047

    Open questions at the time
    • How septins physically bridge AP-3 and ESCRT-I is unresolved
    • Role of LRSAM1 mechanistically undefined
  8. 2017 Medium

    Resolving a non-redundant hematopoietic role, SEPT6-deficient HSCs showed increased engraftment but impaired lymphoid differentiation, establishing SEPT6 control of long-term HSC function and lineage choice.

    Evidence Sept6-deficient mouse model with bone marrow transplantation and flow cytometry of lineages

    PMID:28751190

    Open questions at the time
    • Molecular basis of biased lineage output unknown
    • Reconciliation with earlier redundancy data not addressed
  9. 2018 Medium

    Establishing post-transcriptional control, miR-223 was shown to directly target the SEPT6 3'UTR via AGO2 to downregulate SEPT6 in platelets.

    Evidence AGO2 co-IP, luciferase 3'UTR reporter and anti-miR-223 rescue in stored platelets

    PMID:29943706

    Open questions at the time
    • Functional consequence of SEPT6 loss in platelets not defined
    • Whether this regulation operates outside platelets unknown
  10. 2018 Medium

    Implicating SEPT6 in fibrosis signaling, its overexpression in hepatic stellate cells was shown to drive TGF-β1/Smad-dependent fibrogenic activation in vitro and in vivo.

    Evidence Overexpression/knockdown, pharmacological TGF-β1/Smad blockade and adenoviral knockdown in a rat fibrosis model

    PMID:30315255

    Open questions at the time
    • Direct molecular link between SEPT6 and TGF-β1 induction not defined
    • Single-lab finding
  11. 2021 Medium

    Connecting transcriptional regulation to cancer, LSD1 was shown to demethylate the SEPT6 promoter to upregulate SEPT6 and activate TGF-β1/Smad signaling, promoting NSCLC progression.

    Evidence Lentiviral LSD1 silencing and SEPT6 overexpression with functional assays and xenografts

    PMID:33664458

    Open questions at the time
    • Direct binding of LSD1 to the SEPT6 promoter not demonstrated mechanistically
    • Single-lab finding
  12. 2021 Medium

    Placing SEPT6 in oncogenic signaling, it was shown to promote F-actin formation that inhibits the Hippo pathway and drives YAP nuclear translocation in HCC.

    Evidence Stable knockdown/overexpression with YAP rescue and knockdown epistasis and functional assays

    PMID:33846777

    Open questions at the time
    • How SEPT6/F-actin regulates LATS1 phosphorylation is undefined
    • Single-lab finding
  13. 2021 Medium

    Defining a Mendelian disease link, a germline stop-loss mutation was shown to cause X-linked congenital neutropenia with myeloid tetraploidy, establishing SEPT6 in chromosomal segregation of myeloid progenitors.

    Evidence NGS, CRISPR knock-in/knockout, patient iPSC myeloid colony assays and in silico structural modeling

    PMID:34677878

    Open questions at the time
    • Dimerization-disruption mechanism rests on in silico modeling
    • Single patient case
  14. 2021 Low

    A proposed prostate cancer role placed SEPT6 upstream of ubiquitin C to reduce ubiquitination and inhibit tumor growth.

    Evidence Overexpression/knockdown, immunofluorescence co-localization and xenograft assays

    PMID:34966246

    Open questions at the time
    • Co-localization only; no direct SEPT6-UBC binding assay
    • Epistasis inferred from expression changes alone
  15. 2023 Medium

    Extending function to host defense, zebrafish Sept6-null mutants were viable but more susceptible to Shigella, demonstrating an in vivo role against intracellular bacteria.

    Evidence CRISPR/Cas9 null mutant zebrafish with in vivo Shigella infection and survival analysis

    PMID:36855298

    Open questions at the time
    • Mechanism of septin-mediated bacterial restriction not defined
    • Conservation to mammalian SEPT6 inferred, not tested
  16. 2025 Medium

    Defining a biophysical mechanism, SEPT6 was shown to undergo C-terminal-tail-driven liquid-liquid phase separation that is required for adherens junction integrity and epithelial polarity.

    Evidence In vitro LLPS reconstitution and C-terminal mutant rescue in MDCK 2D/3D cultures with live imaging

    PMID:39973116

    Open questions at the time
    • How LLPS integrates with canonical septin filament assembly unclear
    • Single-lab finding

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how SEPT6's distinct activities — filament scaffolding, LLPS, trafficking coordination, and chromosomal segregation — are partitioned across cell types, and what biochemical activity the MLL-SEPT6 fusion confers in leukemogenesis.
  • No structural model of native SEPT6 heteropolymers in human cells
  • Mechanism of MLL-SEPT6 transformation unresolved
  • Direct enzymatic/GTPase role of SEPT6 not functionally dissected in the corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0008092 cytoskeletal protein binding 2 GO:0060090 molecular adaptor activity 1
Localization
GO:0005856 cytoskeleton 2 GO:0005768 endosome 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-1643685 Disease 2 R-HSA-5653656 Vesicle-mediated transport 1
Partners
AGO2HNRNPA1KMT2ANS5BSEPT12SEPT7
Complex memberships
MLL-SEPT6 fusionSEPT6/SEPT7 complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 SEPTIN6 was identified as a binding partner of HCV NS5b RNA-dependent RNA polymerase by yeast two-hybrid screening, and SEPTIN6 also interacts with hnRNP A1. Knockdown of SEPTIN6 or overexpression of N-terminally truncated SEPTIN6 inhibited HCV replication, establishing a functional role for SEPTIN6 in HCV RNA replication through protein-protein interactions. Yeast two-hybrid screening, coimmunoprecipitation, siRNA knockdown, dominant-negative overexpression Journal of virology Medium 17229681
2002 SEPTIN6 is fused to MLL in infant acute myeloid leukemia via t(X;11)(q24;q23) and related complex rearrangements, generating an MLL-SEPTIN6 fusion protein containing almost the entire SEPTIN6 sequence. SEPTIN6 encodes at least two protein isoforms by alternative splicing. The fusion protein structure parallels other MLL-septin fusions (MLL-CDCREL1, MLL-MSF), suggesting a common leukemogenic pathway. RT-PCR, sequencing, Southern blot, cytogenetics, FISH Cancer research Medium 11477664 11809673 12096348 18492691
2002 The MLL genomic breakpoint in the MLL-SEPTIN6 rearrangement was identified as a functional DNA topoisomerase II cleavage site in an in vitro cleavage assay, implicating topoisomerase II activity in generating the chromosomal translocation. In vitro topoisomerase II cleavage assay, panhandle PCR, Southern blot Oncogene Medium 12096348
2005 Sept6-deficient mice showed no gross abnormalities, no cytokinesis defects, and no spontaneous malignancy. Loss of Sept6 did not alter levels of other septins, did not worsen the Sept4-null phenotype, and did not affect the myeloproliferative disease induced by MLL-SEPT6, indicating that SEPT6 does not function as a tumor suppressor and that there is high redundancy within the septin system. Gene knockout (Sept6-deficient mice), bone marrow transplantation, retroviral MLL-SEPT6 expression, in vitro siRNA of Sept11 Molecular and cellular biology High 16314519
2011 SEPT6 localizes to branch points of developing dendrites and to bases of filopodia and spines in hippocampal neurons, forming ring-like structures (~0.5 μm diameter). SEPT6 is expressed beginning at stage 4 (dendritic outgrowth) and is not a post-synaptic density (PSD) protein. RNAi knockdown of SEPT6 at early developmental stage significantly reduced dendritic length and branch number, demonstrating a role in dendritic cytoarchitecture. Immunocytochemistry, detergent extraction fractionation, RNAi knockdown with morphological quantification in dissociated hippocampal cultures Molecules and cells Medium 21544625
2014 SEPT6 and SEPT7 complexes bound to F-actin regulate protein sorting during multivesicular body (MVB) biogenesis. These complexes bind the AP-3 adaptor complex, modulate AP-3 membrane interactions and motility of AP-3-positive endosomes. SEPT6/SEPT7 interactions also influence membrane association of ESCRT-I, coordinating two cargo-sorting machineries during MVB biogenesis. This coordination requires the E3 ubiquitin ligase LRSAM1. Co-immunoprecipitation, siRNA knockdown, live-cell imaging of endosome motility, subcellular fractionation PloS one Medium 25380047
2007 SEPT12 interacts with SEPT6 both in vitro and in vivo (in HeLa cells), independently of the SEPT6 coiled-coil domain. Co-expression of SEPT12 altered the filamentous structure of SEPT6 in HeLa cells, demonstrating that septin-septin interactions modulate SEPT6 filament organization. Co-immunoprecipitation, in vitro binding assay, co-expression with fluorescence microscopy in HeLa cells, deletion mutant analysis Journal of biochemistry and molecular biology Medium 18047794
2021 LSD1 demethylates the SEPT6 promoter to positively regulate SEPT6 expression at the transcriptional level. LSD1-mediated upregulation of SEPT6 activates the TGF-β1/Smad signaling pathway to promote NSCLC cell proliferation, migration, invasion, and in vivo metastasis. Lentivirus-mediated LSD1 silencing and SEPT6 overexpression, RT-qPCR, western blotting, EdU proliferation assay, Transwell assay, flow cytometry, xenograft mouse model Cancer gene therapy Medium 33664458
2021 SEPT6 promotes HCC cell proliferation, migration, and invasion by facilitating F-actin formation, which leads to LATS1 dephosphorylation, Hippo pathway inhibition, and YAP nuclear translocation with downstream upregulation of cyclin D1 and MMP2. YAP overexpression rescued SEPT6-knockdown phenotypes and YAP knockdown blocked SEPT6-overexpression effects, placing SEPT6 upstream of YAP in HCC. Stable knockdown/overexpression cell lines, CCK-8, flow cytometry, Transwell assay, YAP rescue and knockdown epistasis, western blotting International journal of oncology Medium 33846777
2018 SEPT6 overexpression in hepatic stellate cells (HSCs) promotes TGF-β1 expression and phosphorylation of Smad2, Smad3, ERK, JNK, SAPK-2, and AKT, driving fibrogenic activation. Blockade of TGF-β1/Smad signaling reversed SEPT6 overexpression effects on α-SMA, cyclin D1, BCL2, and MMP-2/-9. In vivo, adenovirus-mediated SEPT6 inhibition attenuated TAA-induced liver fibrosis in rats. Overexpression/knockdown in HSC lines, pharmacological TGF-β1/Smad blockade (SB431542), in vivo adenovirus-mediated knockdown in rat fibrosis model, western blotting Laboratory investigation Medium 30315255
2017 SEPT6-deficient hematopoietic stem cells (HSCs) exhibit increased engraftment potential but impaired lymphoid differentiation, with reduced T-cell and increased B-cell contribution. Multipotent progenitor cells showed distinct SEPT6 filament organization but were functionally unimpaired by SEPT6 deficiency, indicating SEPT6 specifically regulates long-term HSC function and lymphoid lineage choice. Sept6-deficient mouse model, bone marrow transplantation, flow cytometry of hematopoietic lineages, fluorescence microscopy of septin filaments Experimental hematology Medium 28751190
2021 A germline stop-loss mutation in SEPT6 caused X-linked congenital neutropenia with myeloid tetraploidy in a male infant. Reduced SEPT6 staining was found in bone marrow granulocyte precursors and megakaryocytes. SEPT6 KO in an erythroid cell line produced multinucleation. In silico modeling predicted the mutation disrupts SEPT6 coiled-coil dimerization, impairing filament formation. These data establish a critical role for SEPT6 in chromosomal segregation in myeloid progenitors. Next-generation sequencing, CRISPR/Cas9 knock-in and knockout, iPSC myeloid colony assay, immunohistochemistry, in silico structural modeling American journal of hematology Medium 34677878
2023 Zebrafish Sept6-null mutants are viable without gross developmental defects but are more susceptible to Shigella infection, demonstrating a role for Sept6 in host defence against intracellular bacterial pathogens in vivo. CRISPR/Cas9 null mutant generation, in vivo Shigella infection model in zebrafish larvae, survival analysis, RT-qPCR of other septin genes Cytoskeleton (Hoboken, N.J.) Medium 36855298
2018 In stored platelets, miR-223 directly targets the 3'UTR of SEPT6 mRNA and downregulates SEPT6 expression. SEPT6 mRNA co-immunoprecipitates with AGO2 in platelet extracts, and a luciferase reporter with SEPT6 3'UTR is downregulated by miR-223, establishing miR-223 as a post-transcriptional regulator of SEPT6 in platelets. AGO2 co-immunoprecipitation, luciferase reporter assay with SEPT6 3'UTR, anti-miR-223 rescue in platelets MicroRNA (Shariqah, United Arab Emirates) Medium 29943706
2025 SEPT6 undergoes liquid-liquid phase separation (LLPS) both in vitro and in vivo in polarized epithelial (MDCK) cells, mediated by weak, multivalent interactions through its C-terminal tail. SEPT6 mutants defective in LLPS in vitro also fail to support adherens junction integrity and cell polarity establishment in 2D and 3D cultures, demonstrating that LLPS-competent SEPT6 is required for epithelial polarity. In vitro LLPS assay, live-cell imaging of septin dynamics in MDCK cells, SEPT6 C-terminal tail mutant analysis, 3D lumen formation assay Journal of molecular cell biology Medium 39973116
2021 SEPT6 acts upstream of UBC (ubiquitin C) in prostate cancer cells: SEPT6 overexpression decreased UBC expression while SEPT6 knockdown increased it, and SEPT6 co-localizes with UBC in prostate cancer cells by immunofluorescence. SEPT6 inhibited tumor growth in vivo through this UBC-mediated reduction of overall ubiquitination levels. Overexpression/knockdown, immunofluorescence co-localization, CCK-8, flow cytometry, xenograft tumor formation Mediators of inflammation Low 34966246
2019 SEPT6 overexpression in dairy cow mammary epithelial cells upregulates mTOR, p-mTOR, S6K1, and p-S6K1, promoting cell growth and casein (CSN2) synthesis. mTOR inhibition blocked the effects of SEPT6 overexpression, placing SEPT6 upstream of the mTORC1 pathway in amino acid-mediated casein synthesis. Overexpression/inhibition of SEPT6, mTOR inhibition rescue, western blotting, cell growth assays in primary dairy cow mammary epithelial cells The Journal of dairy research Low 31122298

Source papers

Stage 0 corpus · 26 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. Journal of virology 88 17229681
2014 MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer. Scientific reports 67 25519054
2002 SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24. Cancer research 51 11809673
2005 Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4. Molecular and cellular biology 50 16314519
2011 Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions. Molecules and cells 48 21544625
2002 MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site. Oncogene 47 12096348
2001 An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2. Genes, chromosomes & cancer 42 11477664
2021 LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis. Cancer gene therapy 22 33664458
2003 MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature. Genes, chromosomes & cancer 22 12874781
2014 Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis. PloS one 21 25380047
2008 Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions. Haematologica 15 18492691
2021 SEPT6 drives hepatocellular carcinoma cell proliferation, migration and invasion via the Hippo/YAP signaling pathway. International journal of oncology 14 33846777
2007 SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells. Journal of biochemistry and molecular biology 14 18047794
2006 MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia. Cancer genetics and cytogenetics 12 16843108
2018 Effect of SEPT6 on the biological behavior of hepatic stellate cells and liver fibrosis in rats and its mechanism. Laboratory investigation; a journal of technical methods and pathology 10 30315255
2017 Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. Experimental hematology 10 28751190
2023 Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Cytoskeleton (Hoboken, N.J.) 9 36855298
2021 UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer. Mediators of inflammation 8 34966246
2025 Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity. Journal of molecular cell biology 6 39973116
2018 MicroRNA-223 Regulates Septin-2 and Septin-6 in Stored Platelets. MicroRNA (Shariqah, United Arab Emirates) 5 29943706
2021 Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6. American journal of hematology 4 34677878
2019 Septin6 regulates cell growth and casein synthesis in dairy cow mammary epithelial cells via mTORC1 pathway. The Journal of dairy research 4 31122298
2025 Molecular and functional characterization of septin 6 in rohu (Labeo rohita) reveals a strong immunopotentiating role and involvement in broad-spectrum disease protection. International journal of biological macromolecules 1 41203180
2022 Clinical profile in KMT2A-SEPT6-positive acute myeloid leukemia: Does it often co-occur with NRAS mutations? Frontiers in medicine 1 36213638
2026 X-linked SEPTIN6-related congenital neutropenia and B cell deficiency. Journal of human immunity 0 42088107
2023 Co-existence of KMT2A::SEPTIN6 fusion and DIS3 variant in a pediatric case with acute myeloid leukemia: a case report and literature review. Frontiers in oncology 0 38152368

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