Affinage

Showing UBA52 — RPL40 is a alias.

UBA52

Ubiquitin-ribosomal protein eL40 fusion protein · UniProt P62987

Length
128 aa
Mass
14.7 kDa
Annotated
2026-06-10
31 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

UBA52 encodes a fusion protein of ubiquitin and the ribosomal protein L40 (RPL40), whose proteolytic separation co-supplies the free ubiquitin pool and the L40 subunit required for ribosome function and protein synthesis; this dual output is essential, as Uba52 deficiency causes embryonic lethality and developmental arrest with reduced proteasome levels (PMID:27829658, PMID:30135083). The L40 moiety is delivered to the ribosome where it is trimethylated at K22 by the methyltransferase SMYD5 through recognition of a KXY motif, a modification that supports translation elongation and limits ribosome collisions (PMID:39048817, PMID:39103523, PMID:40184250). UBA52-derived ubiquitin feeds diverse substrate ubiquitination events, frequently acting with specific E3 ligases: the K63 residue of UBA52 enables CHIP-mediated ubiquitylation of HSP90 and the mitochondrial channel VDAC1, with mitochondrial protection in neuronal models (PMID:36497031, PMID:36755387); UBA52 cooperates with APC11 to drive CCNB1 degradation for cell-cycle progression (PMID:31814919); and it directs ubiquitin-mediated degradation of substrates including ferroportin, DRP1, SREBF1, Daxx, and β-catenin, processes that are gated by competing binding partners (ROCK2, HOPX) and by regulators of UBA52 abundance or processing (USP7, MLKL, NUDT7) that tune the free ubiquitin available for K11/K27/K48/K63-linked chains (PMID:39193909, PMID:38352945, PMID:40615369, PMID:42157941, PMID:41608635, PMID:41553582). Independently of its ubiquitin role, the L40 fragment is recruited to DNA damage sites and antagonizes RNF168-nucleosome engagement to fine-tune H2A/H2AX ubiquitination and 53BP1 recruitment (PMID:37451480). Through these activities UBA52 acts at the intersection of translation, the cell cycle, mitochondrial quality control, autophagy, and DNA damage signaling, and is repeatedly co-opted as a host factor during viral infection (PMID:29867845, PMID:41608635).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2002 Medium

    Established transcriptional control and tissue/subcellular distribution of UBA52, showing it is a glucose- and stress-responsive ribosomal-fraction protein.

    Evidence Promoter deletion/mutagenesis with SEAP reporter, in situ hybridization, immunohistochemistry, and ribosomal fractionation in kidney cells

    PMID:12171997

    Open questions at the time
    • Did not address the ubiquitin moiety's role
    • No connection to specific ubiquitination substrates
  2. 2016 High

    Resolved whether UBA52's two moieties are functionally separable, showing proteolytic cleavage co-supplies ribosomal L40 and free ubiquitin and that ubiquitin is required for cyclin D/cell-cycle regulation.

    Evidence Uba52-knockout mouse (embryonic lethal), cell-based rescue assays, ribosomal fractionation, cyclin D expression analysis

    PMID:27829658

    Open questions at the time
    • Did not identify the processing protease
    • Mechanism linking ubiquitin pool to cyclin D not resolved
  3. 2018 High

    Defined a developmental requirement for UBA52 and linked it to proteasome homeostasis, and separately identified it as a host factor for viral replication.

    Evidence CRISPR/Cas9 biallelic knockout in porcine embryos with proteasome readout (idx1); Co-IP/MS interactome and siRNA knockdown with viral titer assay for influenza A PA (idx13)

    PMID:29867845 PMID:30135083

    Open questions at the time
    • Molecular basis of zygotic-activation arrest unknown
    • Whether viral effect is via ubiquitin supply or direct interaction unresolved
  4. 2019 Medium

    Connected UBA52-derived ubiquitin to APC-driven cell-cycle progression by showing CCNB1 degradation requires both UBA52 and APC11.

    Evidence Co-IP, double knockdown/overexpression epistasis, flow cytometry cell-cycle analysis, xenograft assay

    PMID:31814919

    Open questions at the time
    • Direct E3-substrate architecture not reconstituted
    • Single lab
  5. 2022 Medium

    Identified specific substrate ubiquitination chemistry, showing the K63 residue of UBA52 is required for CHIP-mediated HSP90 ubiquitylation and that UBA52 co-localizes with α-synuclein at mitochondria.

    Evidence Co-IP, in vitro ubiquitylation with K63 mutant, immunofluorescence co-localization

    PMID:36497031

    Open questions at the time
    • Functional consequence of HSP90 ubiquitylation not established
    • Single lab
  6. 2023 Medium

    Extended the CHIP-UBA52 axis to mitochondrial VDAC1 and revealed a moonlighting role of the L40 fragment in DNA damage signaling, plus a role in rRNA production distinct from p53 stress signaling.

    Evidence Co-IP and in vitro ubiquitylation with mitochondrial functional assays (idx3); laser micro-irradiation, RNF168-nucleosome engagement and 53BP1 imaging (idx7); siRNA knockdown with p53 and rRNA readouts across cell lines (idx8)

    PMID:36755387 PMID:37371478 PMID:37451480

    Open questions at the time
    • DNA-damage role tested largely with ectopic fragments
    • Cell-line-dependent p53 responses not mechanistically unified
    • Single labs
  7. 2023 Medium

    Linked UBA52-driven ubiquitination to ferroptosis through ferroportin degradation and identified a small-molecule (hydralazine) competitive inhibitor of UBA52 binding.

    Evidence In vitro/in vivo ubiquitination assays, competitive binding, peripheral nerve injury mouse model, ferroptosis markers

    PMID:38352945

    Open questions at the time
    • Direct E3 ligase for Fpn not defined
    • Single lab
  8. 2024 High

    Identified SMYD5 as the methyltransferase that trimethylates RPL40 K22 and tied this modification to translation output and ribosome collision control.

    Evidence In vitro methylation with recombinant SMYD5, active-site mutagenesis, SMYD5 CRISPR KO, polysome profiling, ribosome collision assay across cancer contexts

    PMID:39048817 PMID:39103523

    Open questions at the time
    • Translational targets selectively affected not enumerated
    • Link between K22me3 and elongation kinetics mechanistically partial
  9. 2024 Medium

    Showed that processing of UBA52 itself is regulated, with MLKL enabling USP7-mediated cleavage to sustain the free ubiquitin pool and K63-linked ubiquitination of autophagy regulators, and that UBA52 loss can drive autophagy via EMC6.

    Evidence Co-IP, mlkl knockout mouse, ubiquitin/K63 assays, snRNA-seq, behavior (idx9); siRNA/shRNA knockdown with autophagy and tumor phenotypes plus bioinformatics (idx11)

    PMID:38445807 PMID:39193909

    Open questions at the time
    • EMC6 link lacks direct interaction evidence (Low confidence)
    • How MLKL controls USP7 access to UBA52 unresolved
  10. 2025 High

    Dissected the SMYD5 recognition rule (KXY motif, +2 tyrosine) and confirmed it is non-histone-directed, while a preprint proposed L40-remodeled specialized ribosomes that favor viral mRNA translation.

    Evidence MS ribosome methylation profiling, recombinant SMYD5 assays, motif analysis, SMYD5 CRISPR KO, polysome analysis (idx6); cryo-EM ribosome structural analysis with viral mRNA binding (idx19, preprint)

    PMID:40184250

    Open questions at the time
    • Specialized-ribosome model awaits peer review (preprint)
    • In vivo relevance of viral-mRNA-preferring ribosomes untested
  11. 2025 Medium

    Broadened the substrate repertoire and regulatory inputs, showing competition (ROCK2 vs UBA52 for DRP1) and partner-dependent activation (Sparc) that gate UBA52-mediated degradation in disease contexts.

    Evidence Co-IP, K48 ubiquitination and competitive binding assays in cholangiocarcinoma models (idx12); Co-IP/MS and KD epistasis in microglia (idx18)

    PMID:40615369 PMID:40917064

    Open questions at the time
    • Sparc-UBA52 lacks direct ubiquitination evidence (Low confidence)
    • How competing partners select substrates not generalized
  12. 2026 Medium

    Consolidated UBA52 as a hub whose abundance/free-ubiquitin output controls degradation of β-catenin, SREBF1, Daxx, and MCT1, with upstream regulators (HOPX, NUDT7, EMMPRIN) tuning these effects across stem-cell, lipid-metabolism, neuronal, and lactylation contexts.

    Evidence Co-IP, competitive binding, linkage-specific (K11/K27/K48/K63) ubiquitination assays, proteasome inhibition, and in vivo genetic/AAV models

    PMID:41553582 PMID:41608635 PMID:41660506 PMID:42157941

    Open questions at the time
    • Cognate E3 ligases for several substrates not identified
    • Whether effects reflect direct UBA52 activity or global ubiquitin-pool changes not always separated
    • Single labs per substrate

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the ribosomal (L40) and ubiquitin-donor functions of UBA52 are coordinated within a single cell, and what determines substrate and chain-linkage selectivity for UBA52-derived ubiquitin, remain unresolved.
  • No unified model linking translation regulation to substrate-specific ubiquitination
  • Chain-type selection (K11/K27/K48/K63) mechanism undefined
  • Cognate E3 ligases for most named substrates unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0005198 structural molecule activity 3 GO:0031386 protein tag activity 3
Localization
GO:0005840 ribosome 4 GO:0005739 mitochondrion 2 GO:0005634 nucleus 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-1640170 Cell Cycle 2 R-HSA-9612973 Autophagy 2 R-HSA-162582 Signal Transduction 1 R-HSA-73894 DNA Repair 1
Partners
APC11CHIPDRP1HSP90MLKLSMYD5USP7VDAC1
Complex memberships
80S ribosome (L40/RPL40 subunit)

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 UBA52 encodes a fusion protein of ubiquitin and ribosomal protein L40 (RPL40); proteolytic cleavage of RPL40 from UBA52 is required for maintaining protein synthesis, and RPL40 forms a ribosomal complex with ubiquitin co-supplied by UBA52. Expression of RPL40 alone (without the ubiquitin moiety) is insufficient to regulate cyclin D expression or rescue cell-cycle arrest caused by UBA52 deficiency. Knockout mouse model (Uba52-deficient embryonic lethality), cell-based overexpression/rescue assays, ribosomal fractionation, cyclin D expression analysis Scientific reports High 27829658
2018 UBA52 (Uba52) is essential for preimplantation embryo development; CRISPR/Cas9-mediated biallelic knockout in porcine embryos causes developmental arrest at the 4-to-8-cell transition (around major zygotic genomic activation), reduces proteasome protein levels, and causes abnormal nuclear morphology. CRISPR/Cas9 gene editing in porcine oocytes, in vitro fertilization, immunolabeling, western blotting, PCR genotyping Biology open High 30135083
2022 UBA52 physically interacts with α-synuclein, HSP90, and E3-ubiquitin ligase CHIP; the lysine-63 residue of UBA52 is required for CHIP-mediated ubiquitylation of HSP90 in vitro. UBA52 co-localizes with α-synuclein in the mitochondrion. In silico prediction, mass spectrometry, co-immunoprecipitation, in vitro ubiquitylation assay with K63 mutant, immunofluorescence co-localization Cells Medium 36497031
2023 UBA52 interacts with mitochondrial outer membrane channel protein VDAC1 and participates in CHIP-mediated ubiquitylation of VDAC1, as shown by mass spectrometry, co-immunoprecipitation, and in vitro ubiquitylation assay. UBA52 overexpression preserves mitochondrial membrane potential, complex I activity, and prevents cytochrome c release and mPTP opening in a Parkinson's disease neuronal model. Mass spectrometry, co-immunoprecipitation, in vitro ubiquitylation assay, mitochondrial functional assays (JC-1, cytochrome c translocation, calcium uptake, mPTP) ACS chemical neuroscience Medium 36755387
2019 Degradation of CCNB1 (cyclin B1) depends on UBA52-mediated ubiquitylation, which in turn requires APC11. Knockdown of APC11 causes G2/M arrest even when UBA52 is overexpressed, placing APC11 downstream of or in concert with UBA52 in CCNB1 degradation for cell cycle progression. Co-immunoprecipitation, shRNA/siRNA knockdown, overexpression, flow cytometry cell cycle analysis, xenograft tumor assay American journal of translational research Medium 31814919
2024 SMYD5 trimethylates RPL40 (the C-terminal ribosomal protein encoded by UBA52) at lysine 22 (K22me3); recombinant SMYD5 has robust in vitro methyltransferase activity toward RPL40 K22, active-site mutations ablate this activity, and SMYD5 knockout leads to complete loss of RPL40 K22me3 and reduced translation output with increased ribosome collisions in gastric cancer cells. Biochemical-proteomics, in vitro methylation assay with recombinant SMYD5, active-site mutagenesis, SMYD5 CRISPR knockout, polysome profiling, ribosome collision assay Nature High 39048817 39103523
2025 SMYD5 catalyzes RPL40 K22 trimethylation through recognition of a KXY motif; systematic analysis shows SMYD5 does not methylate histones in vitro, and requires a tyrosine at the +2 position of the target peptide. Loss of SMYD5 in K562 cells causes complete loss of RPL40 K22me3 and decreased polysome levels. Mass spectrometry-based ribosome methylation profiling, in vitro methylation of synthetic RPL40 using fractionated lysate, recombinant SMYD5 activity assay, active-site mutagenesis, SMYD5 CRISPR KO, polysome analysis, systematic KXY motif analysis Cell reports High 40184250
2023 The C-terminal ribosomal fragment L40 (encoded by UBA52) masks the regulatory acidic residues E143/E144 and the nucleosome acidic patch to limit RNF168-nucleosome engagement, thereby antagonizing RNF168-mediated H2A/H2AX ubiquitination at K13/15 and impairing 53BP1 recruitment to DNA damage sites. UBA52 (and UBA80/RPS27A) are recruited to laser-induced DNA damage sites and are required for DNA repair. Laser micro-irradiation recruitment assay, ectopic expression of C-terminal fragments, RNF168-nucleosome engagement assay, H2A ubiquitination assay, 53BP1 recruitment imaging The Journal of biological chemistry Medium 37451480
2023 RPL40 knockdown did not stabilize p53 in U2OS cells and did not block p53 stabilization following actinomycin D-induced ribosome biogenesis inhibition, indicating RPL40 is not required for the ribosomal protein–MDM2–p53 stress-signaling pathway in these cells. However, in MCF7 and LNCaP cells, combined knockdown of RPL40 and RPS27a robustly induced p53. RPL40 knockdown impairs rRNA production in all cell lines tested. siRNA knockdown, actinomycin D treatment, p53 western blotting, rRNA production assay, multiple cell lines Biomolecules Medium 37371478
2024 MLKL physically binds UBA52 under physiological conditions; loss of MLKL prevents USP7-mediated cleavage/processing of UBA52, reducing free ubiquitin levels and thereby decreasing K63-linked polyubiquitination of BECN1 and ULK1, which impairs autophagy in the brain. Co-immunoprecipitation, mlkl knockout mouse, ubiquitin level measurement, K63-ubiquitination assay, single-nucleus RNA sequencing, behavioral testing Autophagy Medium 39193909
2023 UBA52-driven ubiquitination promotes degradation of ferroportin (Fpn) via accelerated ubiquitination triggered by reactive oxygen species at the nerve injury site; hydralazine binds UBA52 and competitively inhibits this interaction, reducing Fpn ubiquitination and protecting neurons from ferroptosis. In vitro and in vivo ubiquitination assays, competitive binding assay, peripheral nerve injury mouse model, ferroptosis markers, motor function assessment Journal of pharmaceutical analysis Medium 38352945
2024 UBA52 knockdown induces autophagy through EMC6 in hepatocellular carcinoma cells, suppressing HCC cell growth and metastasis both in vitro and in vivo. siRNA/shRNA knockdown, CCK-8, colony formation, wound healing, Transwell, xenograft mouse model, bioinformatic autophagy pathway analysis Journal of cellular and molecular medicine Low 38445807
2025 ROCK2 competes with UBA52 to bind DRP1, thereby preventing UBA52-mediated K48-linked ubiquitination and proteasomal degradation of DRP1; this ROCK2/UBA52/DRP1 axis drives pemigatinib resistance in cholangiocarcinoma by stabilizing DRP1 to suppress ferroptosis. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, overexpression, competitive binding assay, in vitro and in vivo tumor models Cell death & disease Medium 40615369
2018 UBA52 interacts with influenza A virus PA, PA-N155, and PA-N182 proteins in chicken cells; knockdown of UBA52 significantly decreased H5N1 influenza virus titer and attenuated proinflammatory cytokine production, indicating UBA52 is a host factor required for viral replication. Immunoprecipitation, mass spectrometry interactome, siRNA knockdown, viral titer assay, cytokine measurement Frontiers in microbiology Medium 29867845
2026 UBA52 directly promotes ubiquitin-mediated degradation of β-catenin; HOPX directly inhibits the UBA52-β-catenin interaction to stabilize β-catenin and activate Wnt/β-catenin signaling in intestinal stem cells in a high-iron context. Co-immunoprecipitation, competitive binding assay, ubiquitination assay, Hopx+ ISC lineage tracing, CRC mouse model International journal of biological sciences Medium 42157941
2026 NUDT7 targets UBA52 for proteasomal degradation, reducing free ubiquitin and blocking UBA52-mediated K11/K27/K48-linked polyubiquitination of SREBF1, thereby stabilizing SREBF1 to enhance lipid droplet formation and create a favorable environment for PRRSV replication. Co-immunoprecipitation, ubiquitination assay (K11/K27/K48 linkage-specific), proteasome inhibitor assay, siRNA knockdown, lipid droplet staining, viral replication assay International journal of biological sciences Medium 41608635
2026 EMMPRIN downregulates UBA52 expression, reducing the free ubiquitin pool and decreasing K63-linked polyubiquitination of monocarboxylate transporter 1 (MCT1), leading to MCT1 destabilization and global increase in protein lactylation. Proteomic sequencing, mass spectrometry, co-immunoprecipitation, western blotting, K63-linkage ubiquitination assay, EMMPRIN KO/OE mouse and cell models Frontiers in pharmacology Medium 41660506
2026 UBA52 promotes Daxx ubiquitination and proteasomal degradation; UBA52 overexpression reduces hemin-induced neuronal apoptosis and mitochondrial dysfunction, and this protective effect is abolished by Daxx overexpression, placing Daxx downstream of UBA52. IP-LC/MS, co-immunoprecipitation, AAV9 overexpression in ICH mouse model, TUNEL assay, JC-1 staining, MitoTracker, caspase-3/9 measurement, rescue experiment with Daxx overexpression Molecular neurobiology Medium 41553582
2025 Sparc physically interacts with UBA52 (identified by immunoprecipitation/mass spectrometry and validated by co-immunoprecipitation) and upregulates UBA52 expression; knockdown of Uba52 abolishes the anti-inflammatory and mitochondrial-protective effects of Sparc overexpression in LPS-stimulated microglial cells. Immunoprecipitation + mass spectrometry, co-immunoprecipitation, siRNA knockdown, co-culture with neurons, cytokine ELISA, ROS/mitochondrial potential assays Frontiers in bioscience (Landmark edition) Low 40917064
2025 During non-segmented negative-sense viral infection, rpL40 (the ribosomal protein encoded by UBA52) is recruited to a noncanonical site on the small subunit of 80S ribosomes near the mRNA entry site, forming specialized ribosomes that preferentially bind viral mRNAs to enhance viral protein synthesis critical for replication. Cryo-EM/structural ribosome analysis, ribosome fractionation, viral infection model, mRNA binding assay bioRxivpreprint Medium
2002 The UbA52 promoter contains glucose-responsive E-box sequences and stress response elements (STRE); mutations in the first E-box or STRE reduce promoter activity under high glucose conditions in kidney cells, and UbA52 protein localizes to renal tubules and ribosomal fractions. Promoter deletion constructs with SEAP reporter, site-directed mutagenesis, primer extension, in situ hybridization, immunohistochemistry, ribosomal fractionation The Journal of biological chemistry Medium 12171997

Source papers

Stage 0 corpus · 31 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Scientific reports 99 27829658
2019 LUCAT1 promotes colorectal cancer tumorigenesis by targeting the ribosomal protein L40-MDM2-p53 pathway through binding with UBA52. Cancer science 93 30690837
2019 Degradation of CCNB1 mediated by APC11 through UBA52 ubiquitination promotes cell cycle progression and proliferation of non-small cell lung cancer cells. American journal of translational research 39 31814919
2024 SMYD5 methylation of rpL40 links ribosomal output to gastric cancer. Nature 35 39048817
2018 Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52) is essential for preimplantation embryo development. Biology open 30 30135083
2008 The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea. Neuroscience 24 18448257
2022 UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease. Cells 23 36497031
2002 Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy. The Journal of biological chemistry 22 12171997
1994 Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12. Genomics 20 8188300
2018 Host Interaction Analysis of PA-N155 and PA-N182 in Chicken Cells Reveals an Essential Role of UBA52 for Replication of H5N1 Avian Influenza Virus. Frontiers in microbiology 17 29867845
2023 UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death. ACS chemical neuroscience 15 36755387
2024 Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression. Journal of cellular and molecular medicine 13 38445807
2024 SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma. Cell research 13 39103523
2023 Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52. Journal of pharmaceutical analysis 11 38352945
2023 RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling. Biomolecules 10 37371478
1992 The human ubiquitin/52-residue ribosomal protein fusion gene subfamily (UbA52) is composed primarily of processed pseudogenes. Genomics 9 1330885
2024 MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis. Autophagy 8 39193909
2023 UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair. The Journal of biological chemistry 7 37451480
2025 Targeting the ROCK2/UBA52/DRP1 axis enhances ferroptosis and overcomes pemigatinib resistance in Cholangiocarcinoma. Cell death & disease 5 40615369
2021 Clinical significance of UbA52 level in the urine of patients with type 2 diabetes mellitus and diabetic kidney disease. Nefrologia 5 36165137
2019 Toxoplasma gondii RPL40 is a circulating antigen with immune protection effect. Folia parasitologica 3 31592775
2014 A new reliable reference gene UBA52 for quantitative real-time polymerase chain reaction studies in pyloric cecal tissues of the starfish Asterias rubens. Genetics and molecular research : GMR 3 24938608
2025 UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models. Ecotoxicology and environmental safety 1 40090168
2025 Sparc Suppresses Microglial Neuroinflammation and Promotes Axonal Regeneration by Interacting With Uba52. Frontiers in bioscience (Landmark edition) 1 40917064
2026 UBA52 Overexpression Ameliorates Intracerebral Hemorrhage-Associated Neuronal Apoptosis and Mitochondrial Dysfunction: A Protective Role in Neurons. Molecular neurobiology 0 41553582
2026 NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis. International journal of biological sciences 0 41608635
2026 EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52-MCT1 axis. Frontiers in pharmacology 0 41660506
2026 Competitive Binding of UBA52 and HOPX Modulates β-catenin Stability in Colorectal Cancer in the Context of High-Iron Intake. International journal of biological sciences 0 42157941
2025 SMYD5 is a ribosomal methyltransferase that trimethylates RPL40 lysine 22 through recognition of a KXY motif. Cell reports 0 40184250
2025 Glutathion peroxidase 4 (GPX4) and Ribosomal Protein L40 (RPL40) participate in arsenic induced progression of renal cell carcinoma by regulating the NLRP3 mediated classic pyroptosis pathway. International journal of biological macromolecules 0 40239794
2025 Study on the molecular mechanism of UBA52 and BARD1 regulating hepatocellular carcinoma through the PI3 K/AKT signaling pathway. Discover oncology 0 40397202

Missed literature

Know a paper Affinage missed for UBA52? Flag it for the maintainers and the community.

No submissions yet.