Affinage

RPL35

Large ribosomal subunit protein uL29 · UniProt P42766

Round 2 corrected
Length
123 aa
Mass
14.6 kDa
Annotated
2026-04-28
80 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL35 (uL29) is a core structural protein of the 60S ribosomal large subunit that functions in ribosome biogenesis, translational regulation, and several extra-ribosomal signaling pathways. Its eukaryote-specific C-terminal expansion segment mediates nuclear import and ribosome docking to the endoplasmic reticulum, and in yeast it is essential for 27SB-to-7S pre-rRNA processing and nucleolar release of pre-60S particles (PMID:20392820, PMID:18523488). Beyond translation, RPL35 enhances E2F1 protein synthesis when engaged by the lncRNA lncNB1 and promotes aerobic glycolysis through an ERK/HIF1α axis in neuroblastoma (PMID:31690716, PMID:34873488), suppresses chondrocyte senescence by restraining Hedgehog/Gli1 signaling (PMID:38596341), modulates ER stress via the PERK/eIF2α pathway under stabilization by GADD45GIP1 (PMID:40604925), and acts as an antiviral effector that recruits the E3 ligase AMFR to drive K48-linked ubiquitination and proteasomal degradation of FMDV capsid protein VP2 (PMID:41065387).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1977 High

    Establishing RPL35 as a bona fide structural component of the 60S large ribosomal subunit resolved its identity among the dozens of ribosomal proteins purified from rat liver.

    Evidence Ion-exchange chromatography, gel filtration, SDS-PAGE, and amino acid composition analysis of rat liver 60S subunit proteins

    PMID:863909

    Open questions at the time
    • Post-translational modifications unknown
    • No functional data on ribosome assembly role
  2. 1990 High

    Determination of the full primary structure (122 aa, 14.4 kDa) and recognition of homology to archaeal L29E/bacterial L29 placed RPL35 within an evolutionarily conserved ribosomal protein family and revealed a multigene family in the rat genome.

    Evidence cDNA sequencing, N-terminal protein sequencing, Southern blot hybridization

    PMID:2322279

    Open questions at the time
    • No structural model of RPL35 in the ribosome
    • No functional characterization of the eukaryote-specific extension
  3. 2008 Medium

    Functional dissection of the eukaryote-specific C-terminal expansion segment revealed dual roles: the proximal 25 residues are required for nuclear import while the distal 29 residues mediate ribosome–ER docking, establishing RPL35 as a key determinant of ribosome targeting.

    Evidence Deletion mutagenesis, in vivo recombinant ribosome analysis, and nuclear import assays in human cells

    PMID:18523488

    Open questions at the time
    • Structural basis of ER docking contact not resolved
    • Import receptor identity not identified
    • Single-lab study
  4. 2010 High

    Demonstrating that L35 depletion in yeast blocks 27SB pre-rRNA cleavage at site C2 and traps pre-60S particles in the nucleolus established RPL35 as essential for a specific step in 60S ribosome biogenesis.

    Evidence Conditional depletion, pulse-chase labeling, northern blot, primer extension, sucrose gradients, fluorescence microscopy in S. cerevisiae

    PMID:20392820

    Open questions at the time
    • Mechanism by which RPL35 promotes C2 cleavage not dissected
    • Human rRNA processing role not directly tested
  5. 2015 Medium

    Discovery that RPL35 directly binds eEF2 and controls β-casein translational elongation and ER-directed secretion in mammary cells provided the first evidence of an extra-ribosomal translational regulatory function for RPL35.

    Evidence Co-immunoprecipitation, FRET, co-localization, knockdown and overexpression in bovine mammary epithelial cells

    PMID:26297660

    Open questions at the time
    • Whether RPL35-eEF2 interaction occurs on or off the ribosome unclear
    • Generalizability beyond β-casein not tested
  6. 2019 High

    Identification of lncNB1 as an RPL35-binding lncRNA that stimulates E2F1 protein synthesis, ERK signaling, and N-Myc stabilization in neuroblastoma linked RPL35 to oncogenic translational control and in vivo tumor growth.

    Evidence RNA pull-down, Co-IP, ribosome profiling, shRNA knockdown, xenograft mouse model

    PMID:31690716

    Open questions at the time
    • Mechanism by which lncNB1-RPL35 complex selectively enhances E2F1 translation not elucidated
    • Specificity of lncNB1 for RPL35 versus other ribosomal proteins not fully addressed
  7. 2021 Medium

    Showing that RPL35 knockdown shifts neuroblastoma metabolism from aerobic glycolysis toward mitochondrial respiration through an ERK/HIF1α axis extended RPL35's oncogenic role to metabolic reprogramming.

    Evidence shRNA knockdown, Seahorse metabolic flux assay, Western blot, qRT-PCR in neuroblastoma cells

    PMID:34873488

    Open questions at the time
    • Direct versus indirect regulation of HIF1α by RPL35 not distinguished
    • No rescue experiment with ERK activation reported
  8. 2024 Medium

    Demonstrating that RPL35 loss activates Hedgehog/Gli1 signaling and induces chondrocyte senescence, while RPL35 overexpression protects cartilage in a mouse OA model, revealed a tissue-protective extra-ribosomal role in joint homeostasis.

    Evidence RNA-seq, adenovirus overexpression, destabilization of medial meniscus OA model, immunostaining, cyclic strain loading of primary chondrocytes

    PMID:38596341

    Open questions at the time
    • Direct molecular target linking RPL35 to Hh pathway suppression not identified
    • Whether effect is ribosome-dependent or independent not resolved
  9. 2024 Medium

    Placing RPL35 downstream of EGR1/TENT5A, where TENT5A physically binds RPL35 and negatively regulates mTOR signaling to suppress hepatocellular carcinoma, connected RPL35 to a tumor-suppressive transcriptional–translational axis.

    Evidence ChIP, dual-luciferase assay, Co-IP, GST pull-down with mass spectrometry in HCC cells

    PMID:39570560

    Open questions at the time
    • How TENT5A-RPL35 interaction modulates mTOR not mechanistically resolved
    • Contribution of RPL35 poly(A) tail regulation not addressed
  10. 2025 Medium

    Discovery that GADD45GIP1 stabilizes RPL35 by blocking its ubiquitin-mediated proteasomal degradation, and that RPL35 loss activates PERK/eIF2α ER stress, established RPL35 protein stability as a regulatory node in ER stress signaling.

    Evidence IP/LC-MS/MS, ubiquitination assay, PERK/eIF2α pathway analysis, epistatic rescue experiments in osteosarcoma cells

    PMID:40604925

    Open questions at the time
    • E3 ligase responsible for RPL35 ubiquitination not identified
    • Whether ER stress activation reflects ribosome depletion or a free RPL35 function unclear
  11. 2025 High

    RPL35 was shown to act as an innate antiviral effector by recruiting the E3 ligase AMFR to mediate K48-linked polyubiquitination and proteasomal degradation of FMDV VP2 at Lys217, with FMDV counteracting this by degrading KPNA3 to block RPL35 nuclear translocation.

    Evidence Proteomic screen, Co-IP, ubiquitination assay, site-directed mutagenesis (VP2 K217R), recombinant virus rescue, nuclear translocation assays

    PMID:41065387

    Open questions at the time
    • Whether RPL35 antiviral activity extends to other picornaviruses not tested
    • Structural basis of RPL35-VP2-AMFR ternary complex unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • A unifying structural and mechanistic framework explaining how RPL35 partitions between ribosomal and extra-ribosomal functions—and how its free versus ribosome-bound pools are regulated—remains unresolved.
  • No quantitative model of free versus ribosome-incorporated RPL35 pools
  • No cryo-EM or crystallographic data specifically addressing extra-ribosomal RPL35 conformations
  • Relationship between RPL35 stability regulation and its diverse signaling outputs not integrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0045182 translation regulator activity 2 GO:0003723 RNA binding 1
Localization
GO:0005840 ribosome 3 GO:0005634 nucleus 2 GO:0005783 endoplasmic reticulum 2 GO:0005730 nucleolus 1 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1643685 Disease 3 R-HSA-1852241 Organelle biogenesis and maintenance 1 R-HSA-8953854 Metabolism of RNA 1
Partners
AMFRDDX10EEF2GADD45GIP1KPNA3TENT5A
Complex memberships
60S ribosomal large subunit80S ribosome

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1977 RPL35 (L35) was isolated and purified as a component of the rat liver 60S ribosomal large subunit, with molecular weight estimated by SDS-PAGE and amino acid composition determined, establishing it as a bona fide structural ribosomal protein. Ion-exchange chromatography, gel filtration (Sephadex), SDS-PAGE, amino acid composition analysis The Journal of biological chemistry High 863909
1990 The primary structure of rat 60S ribosomal subunit protein L35 was determined: 122 amino acids (N-terminal Met cleaved post-translationally), molecular weight 14,412 Da. The protein is related to archaebacterial L33/L29E and E. coli L29, and the gene exists in 15–17 copies in the rat genome. cDNA sequencing, N-terminal amino acid sequencing, Southern blot hybridization Biochemical and biophysical research communications High 2322279
2008 The eukaryote-specific C-terminal expansion segment (ES) of human RPL35 was functionally dissected: the first 25 amino acids of the 54-aa ES are essential for nuclear import of the protein, whereas the last 29 residues are dispensable for ribosome structure and translation but serve as a contact site for ribosomal docking to the endoplasmic reticulum. Deletion mutagenesis, in vivo recombinant ribosome analysis, nuclear import assays Biochemistry and cell biology Medium 18523488
2010 In Saccharomyces cerevisiae, L35 is required for processing of 27SB pre-rRNA to 7S pre-rRNA (cleavage at site C2 of ITS2). Depletion of L35 causes a deficit in 60S ribosomal subunits, half-mer polysomes, and blocks release of pre-60S particles from the nucleolus to the nucleoplasm. L35 assembles in the nucleolus and associates with early pre-60S ribosomal particles. Conditional depletion (tetO system), pulse-chase labeling, northern hybridization, primer extension, sucrose gradient sedimentation, fluorescence microscopy Nucleic acids research High 20392820
2015 RPL35 regulates translational elongation of β-casein (CSN2) in bovine mammary epithelial cells by directly interacting with eukaryotic elongation factor 2 (eEF2), placing eEF2 downstream of RPL35 in the methionine signaling pathway. RPL35 also controls CSN2 secretion by localizing it to the endoplasmic reticulum. Co-immunoprecipitation, co-localization microscopy, FRET, gene mutation analysis, overexpression and knockdown experiments Archives of biochemistry and biophysics Medium 26297660
2019 The long noncoding RNA lncNB1 physically binds to RPL35 and enhances E2F1 protein synthesis, leading to DEPDC1B transcription, ERK phosphorylation, and N-Myc protein stabilization. Knockdown of RPL35 or lncNB1 abolishes clonogenic capacity and causes tumor regression in vivo, identifying RPL35 as a key factor for E2F1 translational upregulation in neuroblastoma. RNA pull-down, Co-immunoprecipitation, ribosome profiling, shRNA knockdown, xenograft mouse model Nature communications High 31690716
2021 RPL35 knockdown in neuroblastoma cells decreases aerobic glycolysis and increases mitochondrial respiration, with mechanistic analysis showing that RPL35 positively regulates HIF1α expression (mRNA and protein) and acts through the RPL35/ERK/HIF1α signaling axis. shRNA knockdown, Seahorse metabolic flux assay, Western blot, qRT-PCR American journal of cancer research Medium 34873488
2021 RPL35 was identified as a direct binding partner of the Mycoplasma genitalium adhesin protein MgPa via far-Western blot and co-localization; this interaction promotes expression of translation-initiation proteins (EIF2, SRP68, SERBP1, RPL35A) and EGF/TGF-β, leading to enhanced urothelial cell proliferation. T7 phage display library screening, far-Western blot, co-localization, TMT proteomics, qRT-PCR, MTT proliferation assay Pathogens Low 34832605
2021 RPL35 was identified as a candidate small-molecule binding target: molecular docking and NMR titration studies showed that the FDA-approved drugs atazanavir and artesunate bind to an overlapping cluster near the N-terminus of rpL35, accessible when RPL35 is integrated in the ribosome. This binding site was proposed to modulate translational readthrough at premature stop codons. Molecular docking, NMR chemical shift perturbation mapping Skin pharmacology and physiology Low 33823521
2022 DDX10 interacts with RPL35 in colorectal cancer cells, as identified by LC-MS/MS proteomics and confirmed by co-immunoprecipitation; DDX10 knockdown reduces CRC cell proliferation, migration and invasion, and both proteins are implicated in RNA splicing and E2F target pathways. LC-MS/MS interactome, Co-immunoprecipitation, shRNA knockdown, cell proliferation/migration assays Cancer cell international Low 35109823
2024 RPL35 knockdown in chondrocytes activates the Hedgehog (Hh)/Gli1 signaling pathway, induces cellular senescence, decreases anabolic markers, and increases catabolic markers. In vivo, adenovirus-mediated RPL35 overexpression in a mouse compression loading OA model protects articular cartilage from degeneration. RNA sequencing, adenovirus-mediated overexpression, destabilization of medial meniscus OA model, immunostaining, Western blot, cyclic strain loading of primary chondrocytes Journal of orthopaedic translation Medium 38596341
2024 EGR1 directly binds the TENT5A promoter and drives TENT5A expression; TENT5A then physically interacts with RPL35 (confirmed by Co-IP/GST pull-down with MS), participates in ribosome biogenesis, and negatively regulates the mTOR pathway to suppress HCC proliferation and metastasis. Chromatin immunoprecipitation, dual-luciferase reporter assay, Co-immunoprecipitation, GST pull-down, mass spectrometry Cellular oncology Medium 39570560
2025 GADD45GIP1 physically interacts with RPL35 (ranked second among 263 candidate interactors by IP/LC-MS/MS) and inhibits ubiquitin-mediated proteasomal degradation of RPL35. RPL35 knockdown activates the PERK/eIF2α ER stress pathway and reduces osteosarcoma cell viability; RPL35 overexpression rescues the phenotype caused by GADD45GIP1 knockdown. Immunoprecipitation with LC-MS/MS, Western blot, ubiquitination assay, PERK/eIF2α pathway analysis, rescue experiments Cancer cell international Medium 40604925
2025 RPL35 functions as a host antiviral factor against FMDV by directly binding the viral structural protein VP2, recruiting the E3 ubiquitin ligase AMFR to mediate K48-linked polyubiquitination of VP2 at Lys217, leading to proteasomal degradation of VP2 and suppression of viral replication. FMDV counteracts this by inducing degradation of the nuclear transport protein KPNA3, blocking RPL35 nuclear translocation. Proteomic screen, Co-immunoprecipitation, ubiquitination assay, site-directed mutagenesis (VP2 K217R), recombinant virus rescue, KPNA3 nuclear translocation assay Journal of virology High 41065387

Source papers

Stage 0 corpus · 80 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2010 Network organization of the human autophagy system. Nature 1286 20562859
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2005 Nucleolar proteome dynamics. Nature 934 15635413
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2013 Structures of the human and Drosophila 80S ribosome. Nature 481 23636399
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2011 Defining human ERAD networks through an integrative mapping strategy. Nature cell biology 427 22119785
2010 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research 422 20020773
2013 The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. The Journal of biological chemistry 413 23463506
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 The molecular mechanics of eukaryotic translation. Annual review of biochemistry 396 15189156
2015 Structure of the human 80S ribosome. Nature 380 25901680
2015 Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature methods 370 26414014
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2009 Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell 281 19167051
2003 Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell 276 14567916
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
1995 Structure and evolution of mammalian ribosomal proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire 265 8722009
2011 A directed protein interaction network for investigating intracellular signal transduction. Science signaling 258 21900206
2018 Mapping the Genetic Landscape of Human Cells. Cell 225 30033366
2000 Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2. Journal of virology 96 10933704
2019 The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. Nature communications 84 31690716
1976 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. The Journal of biological chemistry 70 1002715
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of 60 S ribosomal subunit proteins L3, L6, L7', L8, L10, L15, L17, L18, L19, L23', L25, L27', L28, L29, L31, L32, L34, L35, L36, L36', and L37'. The Journal of biological chemistry 68 863909
2010 Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS pathogens 64 20585571
1992 Messenger RNA secondary structure and translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and the ribosomal proteins, L35 and L20. Journal of molecular biology 58 1453449
2010 Ribosomal protein L35 is required for 27SB pre-rRNA processing in Saccharomyces cerevisiae. Nucleic acids research 46 20392820
2005 R-state haemoglobin with low oxygen affinity: crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35. Journal of molecular biology 40 16403522
2009 Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. Journal of virology 33 19625400
2002 Translational feedback regulation of the gene for L35 in Escherichia coli requires binding of ribosomal protein L20 to two sites in its leader mRNA: a possible case of ribosomal RNA-messenger RNA molecular mimicry. RNA (New York, N.Y.) 31 12166643
1996 Suppression of a sensor kinase-dependent phenotype in Pseudomonas syringae by ribosomal proteins L35 and L20. Journal of bacteriology 30 8626280
2003 Mutation of single hydrophobic residue I27, L35, F39, L58, L65, L67, or L71 in the N terminus of VP5 abolishes interaction with the scaffold protein and prevents closure of herpes simplex virus type 1 capsid shells. Journal of virology 25 12634364
2022 DDX10 promotes the proliferation and metastasis of colorectal cancer cells via splicing RPL35. Cancer cell international 24 35109823
2015 60S ribosomal protein L35 regulates β-casein translational elongation and secretion in bovine mammary epithelial cells. Archives of biochemistry and biophysics 24 26297660
1996 A long-range RNA-RNA interaction forms a pseudoknot required for translational control of the IF3-L35-L20 ribosomal protein operon in Escherichia coli. The EMBO journal 23 8861967
2010 Porcine circovirus type 2 morphogenesis in a clone derived from the l35 lymphoblastoid cell line. Journal of comparative pathology 22 20800239
1994 Phorbol ester induction of differentiation and apoptosis in the K562 cell line is accompanied by marked decreases in the stability of globin mRNAs and decreases in the steady state level of mRNAs encoding for ribosomal proteins L35, L31, L27, and L21. Cellular & molecular biology research 20 7804323
2022 18β-glycyrrhetinic acid regulates mitochondrial ribosomal protein L35-associated apoptosis signaling pathways to inhibit proliferation of gastric carcinoma cells. World journal of gastroenterology 18 35979263
2011 RNase Y is responsible for uncoupling the expression of translation factor IF3 from that of the ribosomal proteins L35 and L20 in Bacillus subtilis. Molecular microbiology 18 21843271
2007 A competition mechanism regulates the translation of the Escherichia coli operon encoding ribosomal proteins L35 and L20. Journal of molecular biology 17 18037435
2008 The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking. Biochemistry and cell biology = Biochimie et biologie cellulaire 15 18523488
2021 RPL35 promotes neuroblastoma progression via the enhanced aerobic glycolysis. American journal of cancer research 14 34873488
2020 Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity. Viruses 13 33322225
1996 Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase. Journal of lipid research 12 8728321
1997 Transcriptional induction of cholesterol 7alpha-hydroxylase by dexamethasone in L35 hepatoma cells requires sulfhydryl reducing agents. The Journal of biological chemistry 11 9006961
1990 Ribosomal protein L35: identification in spinach chloroplasts and isolation of a cDNA clone encoding its cytoplasmic precursor. Biochemistry 11 2271612
2024 RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling. Journal of orthopaedic translation 10 38596341
1997 Sequence analysis of the bovine herpesvirus type 1 genes homologous to the DNA polymerase (UL30), the major DNA-binding protein (UL29) and ICP18.5 assembly protein (UL28) genes of herpes simplex virus. Archives of virology 10 9155875
1990 The primary structure of rat ribosomal protein L35. Biochemical and biophysical research communications 10 2322279
2023 Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV-1. Smart medicine 9 39188276
2021 Drug Development for Target Ribosomal Protein rpL35/uL29 for Repair of LAMB3R635X in Rare Skin Disease Epidermolysis Bullosa. Skin pharmacology and physiology 9 33823521
2019 The Role of Marek's Disease Virus UL12 and UL29 in DNA Recombination and the Virus Lifecycle. Viruses 8 30696089
1999 Identification of the Marek's disease virus serotype 2 genes homologous to the glycoprotein B (UL27), ICP18.5 (UL28) and major DNA-binding protein (UL29) genes of herpes simplex virus type 1. The Journal of veterinary medical science 8 10563297
2012 Prokaryotic expression and characteristics of duck enteritis virus UL29 gene. Acta virologica 7 23237085
1986 Monoclonal antibodies, L-35 and L-36, define novel T cell activation antigens. Journal of immunology (Baltimore, Md. : 1950) 7 3095423
2014 Draft genome sequences and description of Lactobacillus rhamnosus strains L31, L34, and L35. Standards in genomic sciences 6 25197459
1996 Translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and ribosomal proteins L20 and L35. Biochimie 6 8955899
2021 Mycoplasma genitalium Protein of Adhesion Promotes the Early Proliferation of Human Urothelial Cells by Interacting with RPL35. Pathogens (Basel, Switzerland) 4 34832605
2018 Detection of Residual Proteins UL5 and UL29 Using a Targeted Proteomics Approach in HSV529, a Replication-Deficient HSV-2 Vaccine Candidate. Journal of pharmaceutical sciences 4 30176254
2013 Determination of HSV-1 UL5 and UL29 gene copy numbers in an HSV complementing Vero cell line. Journal of biotechnology 4 24140636
1996 Characterisation of genes encoding a nucleoside monophosphate kinase and a L35 ribosomal protein from Babesia bovis. Molecular and biochemical parasitology 4 8920009
2024 TENT5A mediates the cancer-inhibiting effects of EGR1 by suppressing the protein stability of RPL35 in hepatocellular carcinoma. Cellular oncology (Dordrecht, Netherlands) 3 39570560
2005 Ribosomal protein genes S23 and L35 from amphioxus Branchiostoma belcheri tsingtauense: identification and copy number. Acta biochimica et biophysica Sinica 3 16077906
2025 GADD45GIP1 promotes osteosarcoma progression by modulating RPL35 ubiquitination and alleviating endoplasmic reticulum stress via the PERK/eIF2α pathway. Cancer cell international 2 40604925
1996 The sequence of 23 kb surrounding the SNF3 locus on the left arm of yeast chromosome IV reveals the location of five known genes and characterizes at least six new open reading frames including putative genes for ribosomal protein L35 and a sugar transport protein. Yeast (Chichester, England) 2 8896272
2024 A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs' Susceptibility. Viruses 1 39772124
2026 Unresolved questions on the GADD45GIP1-RPL35 axis in osteosarcoma: mechanistic links to ER stress and therapeutic targeting. Cancer cell international 0 41606585
2025 Escherichia coli proteins uL29 and ACP stabilize the Tn7-encoded TnsD and its DNA binding. Mobile DNA 0 40847421
2025 Ribosomal protein L35 negatively regulates FMDV replication by recruiting AMFR to promote the ubiquitination and degradation of VP2. Journal of virology 0 41065387
2001 Nucleotide sequence of the porcine 60S ribosomal protein L35 cDNA. DNA sequence : the journal of DNA sequencing and mapping 0 11913794