Affinage

RPL26

Large ribosomal subunit protein uL24 · UniProt P61254

Length
145 aa
Mass
17.3 kDa
Annotated
2026-06-10
100 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL26 (uL24) is a 60S ribosomal subunit protein that doubles as a structural component of the large subunit and an extraribosomal regulator of the p53 tumor-suppressor pathway and ER-associated quality control (PMID:16213212, PMID:30626644). As a ribosomal protein it is positioned at the ribosomal subunit interface and is incorporated into pre-60S particles in the nucleolus, where it optimizes 27S/large-subunit pre-rRNA maturation and subunit assembly (PMID:9672752, PMID:22688513). In its regulatory capacity, RPL26 binds the 5'UTR of p53 mRNA following DNA damage to drive its association with heavier polysomes and enhance p53 translation, producing G1 arrest and augmenting apoptosis (PMID:16213212); it additionally protects p53 mRNA from miR-27a-mediated repression and forms a ternary RPL26–HDM2–p53 complex that inhibits HDM2 ubiquitin ligase activity to stabilize p53 (PMID:20542919, PMID:26687066). This activity is constrained by counter-regulators: Mdm2/HDM2 binds RPL26, drives its polyubiquitylation and proteasomal degradation, and displaces it from p53 mRNA, while nucleolin competes for the same UTR region and modulates RPL26 function through a direct interaction (PMID:18951086, PMID:22433872). RPL26 exerts parallel translational and stability control over the p53 family member p73 (PMID:27825141). Independently, RPL26 is the principal substrate of UFMylation, which occurs on C-terminal lysines K132/K134 by ER-tethered enzyme complexes near the SEC61 translocon; this modification of translocon-bound 60S subunits remodels the ribosome-translocon junction to enable RQC- and proteasome-dependent clearance of stalled secretory nascent chains and supports ER-phagy-dependent intestinal homeostasis (PMID:30626644, PMID:31595041, PMID:37036982, PMID:41962728). A de novo RPL26 deletion causes Diamond-Blackfan anemia through a ribosome biogenesis defect (PMID:22431104).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1998 Medium

    Established the structural placement of RPL26 within the ribosome, defining it as a subunit-interface protein rather than a peripheral component.

    Evidence Chemical cross-linking and 2D diagonal SDS-PAGE of intact 80S ribosomes in yeast

    PMID:9672752

    Open questions at the time
    • Based on yeast ortholog
    • No human structural confirmation
    • Cross-linking infers proximity, not precise contacts
  2. 2005 High

    Revealed an extraribosomal function: RPL26 binds the p53 mRNA 5'UTR after DNA damage to enhance p53 translation, linking a ribosomal protein to the DNA-damage response.

    Evidence RNA binding assays, polysome profiling, gain/loss-of-function with p53 translation and apoptosis readouts

    PMID:16213212

    Open questions at the time
    • Did not define the counter-regulatory machinery
    • Structural basis of UTR recognition unresolved
  3. 2008 High

    Identified Mdm2 as the negative regulator that polyubiquitylates RPL26 and strips it from p53 mRNA, establishing how the p53-translation arm is switched off and re-activated under stress.

    Evidence Reciprocal Co-IP, ubiquitylation and proteasome-inhibitor assays, polysome profiling

    PMID:18951086

    Open questions at the time
    • Ubiquitin ligase responsible not fully resolved in this study
    • Stress-induced attenuation mechanism not detailed
  4. 2010 High

    Showed RPL26 also stabilizes p53 by forming an RPL26-HDM2-p53 ternary complex that inhibits HDM2 ligase activity, adding a non-translational arm responsive to ribosomal stress.

    Evidence Yeast two-hybrid, in vivo/in vitro Co-IP, ubiquitin ligase activity assay, cell cycle readouts

    PMID:20542919

    Open questions at the time
    • Structural basis of HDM2 inhibition unknown
    • Relationship between ligase inhibition and mRNA binding arms not integrated
  5. 2012 High

    Defined nucleolin as a competitor binding the same p53 UTR region and a direct RPL26 partner, refining how p53-mRNA recruitment is balanced.

    Evidence Co-IP, RNA binding, site-directed mutagenesis, dimerization and p53 translation assays

    PMID:22433872

    Open questions at the time
    • Quantitative competition kinetics undefined
    • In vivo relevance of NCL-RPL26 stoichiometry unclear
  6. 2012 Medium

    Linked RPL26 loss to human disease by showing a de novo deletion causes Diamond-Blackfan anemia via defective pre-rRNA processing.

    Evidence Gene sequencing and pre-rRNA processing analysis in patient cells

    PMID:22431104

    Open questions at the time
    • Single patient, single lab
    • Relative contribution of p53 hyperactivation vs biogenesis defect not dissected
  7. 2012 High

    Clarified the conserved biogenesis role: RPL26 optimizes 27S pre-rRNA maturation and pre-60S nuclear export, dissociating its assembly role from translational fidelity.

    Evidence Yeast null mutant, polysome analysis, pre-rRNA processing, DMS probing, translation fidelity assays

    PMID:22688513

    Open questions at the time
    • Yeast ortholog
    • Human pre-rRNA processing dependence not directly shown here
  8. 2015 Medium

    Expanded RPL26's p53-protective function to microRNA defense, showing it blocks miR-27a binding to p53 mRNA and is repressed by the Six1 oncoprotein independently of MDM2.

    Evidence Six1/RPL26 perturbation, luciferase reporters with p53 3'UTR, mutation analysis

    PMID:26687066

    Open questions at the time
    • Single lab
    • Direct RPL26-miR-27a competition not structurally resolved
  9. 2016 Medium

    Generalized RPL26's regulatory reach to p73, acting on both translation (3'UTR binding, eIF4E recruitment) and protein stability via MDM2.

    Evidence RNA pulldown, polysome profiling, Co-IP with eIF4E, reporters, MDM2 CRISPR knockout, growth assays

    PMID:27825141

    Open questions at the time
    • Single lab
    • Mechanistic overlap with p53 regulation not delineated
  10. 2019 High

    Identified RPL26 as the principal UFMylation substrate enriched on ER-bound ribosomes near SEC61, establishing a new post-translational modification axis tied to cotranslational translocation.

    Evidence Mass spectrometry, biochemical fractionation, Ribo-seq, structural modeling, Co-IP

    PMID:30626644

    Open questions at the time
    • Functional consequence of UFMylation initially inferred from proximity
    • Precise enzyme recruitment mechanism not fully resolved
  11. 2019 High

    Pinpointed the UFMylation sites (K132/K134) and showed UFMylation directs lysosomal degradation of stalled nascent chains, with physiological relevance to erythroid secretion in vivo.

    Evidence MS site identification, site-directed mutagenesis, ribosome stalling and lysosomal inhibitor assays, mouse knockout, erythroid differentiation

    PMID:31595041

    Open questions at the time
    • Lysosomal vs proteasomal routing partially context-dependent
    • Mechanism of RTJ sensing of stalls not fully defined
  12. 2023 High

    Defined the mechanism by which RPL26 UFMylation acts: it remodels the ribosome-translocon junction to grant RQC and proteasome access to ER arrest peptides.

    Evidence Cell-based stalling reporters, UFMylation-site mutant complementation, proteasome inhibition, RQC pathway epistasis (peer-reviewed plus preprint)

    PMID:36945571 PMID:37036982

    Open questions at the time
    • Structural detail of RTJ remodeling not directly visualized
    • Reconciliation with lysosomal routing reported earlier unresolved
  13. 2023 Medium

    Connected RPL26 to oncogenic signaling, showing UBE2S-mediated ubiquitination and degradation of RPL26 upregulates c-Myc to drive NSCLC.

    Evidence IP-MS substrate identification, UBE2S perturbation, xenograft model

    PMID:37693154

    Open questions at the time
    • Single lab
    • Mechanistic link between RPL26 degradation and c-Myc not fully defined
  14. 2026 High

    Demonstrated in vivo that RPL26 UFMylation sustains intestinal homeostasis by promoting ER-phagy through ATG16L1 stabilization, preventing Paneth/goblet cell loss.

    Evidence K132/K134R knock-in mice, intestinal histology, ATG16L1 ubiquitination, ER stress markers, flow cytometry

    PMID:41962728

    Open questions at the time
    • Mechanism linking RTJ UFMylation to ATG16L1 stability not fully mapped
    • Tissue specificity of the phenotype not generalized

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPL26's distinct functional modes — ribosomal structure, p53/p73 mRNA regulation, and ER UFMylation-dependent quality control — are coordinated within a single cell, and whether they are mutually exclusive ribosome populations, remains unresolved.
  • No unified model integrating the cytosolic p53-regulatory and ER UFMylation roles
  • Whether UFMylated and p53-mRNA-bound RPL26 are physically distinct pools is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0005198 structural molecule activity 2 GO:0045182 translation regulator activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005783 endoplasmic reticulum 2 GO:0005840 ribosome 2 GO:0005730 nucleolus 1
Pathway
R-HSA-1640170 Cell Cycle 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-8953854 Metabolism of RNA 2 R-HSA-9612973 Autophagy 1
Partners
CDK5RAP3EIF4EMDM2NCLTP53UBE2SUFM1
Complex memberships
60S ribosomal subunitRPL26-HDM2-p53 ternary complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 RPL26 binds to the 5' UTR of p53 mRNA, and its overexpression enhances association of p53 mRNA with heavier polysomes, increases the rate of p53 translation, induces G1 cell-cycle arrest, and augments irradiation-induced apoptosis. After DNA damage, RPL26 preferentially binds the 5'UTR of p53 mRNA to promote p53 protein induction. RNA binding assays, polysome profiling, overexpression and RNAi knockdown with p53 translation readout, irradiation-induced apoptosis assay Cell High 16213212
2008 Mdm2 binds RPL26, drives its polyubiquitylation and proteasomal degradation, and attenuates the association of RPL26 with p53 mRNA, thereby repressing L26-mediated augmentation of p53 protein synthesis. Under genotoxic stress, this inhibitory effect of Mdm2 on RPL26 is attenuated, enabling rapid increase in p53 synthesis. Co-immunoprecipitation, ubiquitylation assays, proteasome inhibitor experiments, polysome profiling, overexpression/knockdown with p53 translation readout Molecular Cell High 18951086
2010 RPL26 interacts with HDM2 to form a ternary complex (RPL26-HDM2-p53) that inhibits the ubiquitin ligase activity of HDM2, thereby stabilizing p53. Ribosomal stress (low-dose actinomycin D) enhances RPL26-HDM2 interaction and activates p53. Overexpression of RPL26 inhibits cell proliferation and induces p53-dependent G1 cell cycle arrest. Yeast two-hybrid, in vivo and in vitro co-immunoprecipitation, ubiquitin ligase activity assay, overexpression with cell proliferation/cell cycle readout Nucleic Acids Research High 20542919
2012 Nucleolin (NCL) and RPL26 interact with each other. NCL binds to the same 5'-3'-UTR interaction region of p53 mRNA that is critical for RPL26 recruitment after DNA damage. NCL oligomerizes via its RNA-binding domain, which also mediates NCL-RPL26 interaction. Excessive RPL26 disrupts NCL dimerization. Point mutations in the NCL-interacting region of RPL26 reduce NCL-RPL26 interactions and attenuate both RPL26 binding to p53 mRNA and p53 induction by RPL26. Co-immunoprecipitation, RNA binding assays, site-directed mutagenesis, dimerization assays, p53 translation assays Journal of Biological Chemistry High 22433872
2012 A de novo two-nucleotide deletion in RPL26 in a Diamond-Blackfan anemia proband causes a ribosome biogenesis defect affecting maturation of both small and large subunits (specific pre-rRNA processing defect), establishing RPL26 as a DBA gene and a regulator of p53 activity. Gene sequencing, pre-rRNA processing analysis (Northern blot or equivalent), patient cell analysis Human Mutation Medium 22431104
2015 The Six1 oncoprotein downregulates RPL26 expression, contributing to decreased p53 levels via a mechanism independent of MDM2. Mutation analysis confirms that RPL26 inhibits miR-27a binding to p53 mRNA and prevents microRNA-mediated downregulation of p53, demonstrating that RPL26 acts as a competitive regulator protecting p53 mRNA from miR-27a. Overexpression/knockdown of Six1 and RPL26, luciferase reporter assays with p53 3'UTR, mutation analysis Nature Communications Medium 26687066
2016 RPL26 regulates p73 expression via two distinct mechanisms: (1) mRNA translation — RPL26 directly binds the 3'UTR of p73 mRNA, is necessary for efficient polysome assembly on p73 mRNA, and enhances association of cap-binding protein eIF4E with p73 mRNA; and (2) protein stability — RPL26 regulates p73 stability partially through MDM2. Knockdown of RPL26 promotes, whereas ectopic expression inhibits, cell growth in a TAp73-dependent manner. RNA pulldown (RPL26 binding to p73 3'UTR), polysome profiling, Co-IP (RPL26-eIF4E), eGFP reporter assays, CRISPR-Cas9 MDM2 knockout, cell growth assays Oncotarget Medium 27825141
2019 RPL26 (uL24) is the principal target of UFMylation. UFMylated RPL26 is highly enriched on ER membrane-bound ribosomes and polysomes. UFMylation and de-UFMylation of RPL26 is catalyzed by enzyme complexes tethered to the cytoplasmic surface of the ER. Structural modeling and biochemical analysis place UFMylated RPL26 and the UFMylation machinery in close proximity to the SEC61 translocon, suggesting a direct role in cotranslational protein translocation into the ER. Mass spectrometry, biochemical fractionation, ribosome profiling (Ribo-seq), structural modeling, Co-IP PNAS High 30626644
2019 RPL26 UFMylation occurs on two conserved lysine residues near the COOH-terminus of RPL26 at the ER upon ribosome stalling during protein translocation. RPL26 UFMylation enables degradation of stalled nascent chains via lysosomal (not proteasomal) targeting. RPL26 UFMylation is upregulated during erythroid differentiation; compromising UFMylation impairs protein secretion and hemoglobin production, causing anemia in mice. Mass spectrometry (identification of UFMylation sites on K132/K134), site-directed mutagenesis, ribosome stalling assays, lysosomal inhibitor experiments, mouse knockout model, erythroid differentiation assays Cell Research High 31595041
2023 UFMylation of RPL26/uL24 at the ribosome-translocon junction (RTJ) is strictly required for UPS- and RQC-dependent degradation of arrest peptides (APs) generated when ribosomes stall during co-translational translocation into the ER. UFMylation of translocon-bound 60S subunits modulates the RTJ to promote access of proteasomes and RQC machinery to ER-arrested peptides. Cell-based stalling reporter assays, genetic complementation with UFMylation-site mutants of RPL26, proteasome inhibitor experiments, RQC pathway analysis PNAS High 37036982
2023 UFMylation of RPL26/uL24 at the ribosome-translocon junction is required for RQC-dependent degradation of ER arrest peptides (preprint version confirming peer-reviewed findings). Cell-based stalling reporters, UFMylation-site mutants of RPL26, proteasome/RQC pathway epistasis bioRxivpreprint Medium 36945571
2023 UBE2S (an E2 ubiquitin-conjugating enzyme) targets RPL26 for ubiquitination and proteasomal degradation, thereby upregulating c-Myc to enhance NSCLC progression. Inhibiting UBE2S suppresses RPL26-c-Myc-mediated tumor growth in vivo. Immunoprecipitation combined with mass spectrometry (substrate identification), overexpression/knockdown of UBE2S, xenograft mouse model American Journal of Cancer Research Medium 37693154
2022 CDK5RAP3 interacts with RPL26 to regulate the mTOR pathway. CDK5RAP3 and RPL26 deficiency inhibited mTOR/p-mTOR and induced autophagy, resulting in increased apoptosis and slowed cell growth. Co-immunoprecipitation (CDK5RAP3-RPL26 interaction), knockdown of CDK5RAP3 and RPL26, mTOR pathway analysis, apoptosis/autophagy assays Cell Proliferation Low 35509151
1998 Yeast ribosomal protein L26 (ortholog of human RPL26/uL24) is located at the ribosomal subunit interface, as determined by chemical cross-linking showing two protein pairs involving L26 and 40S subunit proteins in intact 80S ribosomes. Chemical cross-linking with DSP/SPDP, 2D diagonal SDS-PAGE, fluorescent labeling with IAF Biochimie Medium 9672752
2012 Yeast L26 (ortholog of human RPL26/uL24) assembles into pre-60S ribosomal particles in the nucleus/nucleolus and is mainly required to optimize 27S pre-rRNA maturation; its absence partially impairs release of pre-60S particles from the nucleolus. Ribosomes lacking L26 show differential reactivity to DMS in domain I of 25S/5.8S rRNAs but can support translation in vivo with wild-type accuracy. Yeast genetics (null mutant construction), polysome analysis, pre-rRNA processing analysis, DMS chemical probing, in vivo translation fidelity assays Molecular and Cellular Biology High 22688513
2019 Bacterial homologs of RPL26/uL24 (E. coli uL4 and uL24) individually and cooperatively stabilize a 79-nucleotide fragment of 23S rRNA essential for 50S ribosome assembly, acting as molecular clamps. Binding of both proteins simultaneously enhances mechanical stabilization and they show cooperative binding to the rRNA fragment. Single-molecule force spectroscopy (optical tweezers), in vitro rRNA-protein binding assays RNA Medium 30705137
2021 Polysome profiling using primary B-cells from a DBA patient with a novel RPL26 (uL24) missense variant showed reduced 60S and 80S fractions compared to an unaffected parent, consistent with a large ribosomal subunit assembly defect caused by RPL26 haploinsufficiency. B-cell polysome profiling, comparison of patient vs. unaffected parent Journal of Pediatric Hematology/Oncology Low 33122585
2026 RPL26 UFMylation deficiency (K132/K134R knock-in mice) in intestinal epithelial cells suppresses ER-phagy by promoting ubiquitin-mediated degradation of ATG16L1, triggering ER stress-dependent apoptosis in Paneth cells and causing loss of goblet and Paneth cells, shortened intestine, and elevated inflammation. Knock-in mouse model (RPL26 UFMylation site mutant), intestinal histology, ATG16L1 ubiquitination assays, ER stress markers, flow cytometry Cellular Signalling High 41962728

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 544 16213212
2008 Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Molecular cell 201 18951086
1988 Hodgkin's disease, lymphocyte predominance type, nodular--further evidence for a B cell derivation. L & H variants of Reed-Sternberg cells express L26, a pan B cell marker. The American journal of pathology 173 3263805
2019 Ribosomal protein RPL26 is the principal target of UFMylation. Proceedings of the National Academy of Sciences of the United States of America 162 30626644
1987 Utilization of monoclonal antibody L26 in the identification and confirmation of B-cell lymphomas. A sensitive and specific marker applicable to formalin-and B5-fixed, paraffin-embedded tissues. The American journal of pathology 162 3322020
2019 UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis. Cell research 152 31595041
1990 Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. The American journal of pathology 152 1694056
1987 Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. Journal of clinical pathology 137 3323247
2012 Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Human mutation 125 22431104
2017 Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation. Journal of virology 107 28100608
2012 Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. The Journal of biological chemistry 106 22433872
1989 Immunophenotypic diagnosis of non-Hodgkin's lymphoma in paraffin sections. Co-expression of L60 (Leu-22) and L26 antigens correlates with malignant histologic findings. American journal of clinical pathology 84 2718958
2010 Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26. Nucleic acids research 82 20542919
1998 Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice. Virology 81 9501052
1976 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. The Journal of biological chemistry 70 1002715
2007 Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin. Virology 68 17346762
2023 RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 66 37036982
2000 Immunoreactivity of B-cell markers (CD79a, L26) in rare cases of extranodal cytotoxic peripheral T- (NK/T-) cell lymphomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 63 10912936
2002 Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1. Journal of virology 51 12368325
2015 The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature communications 50 26687066
2012 Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells. Molecular and cellular biochemistry 50 22868929
2011 Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress. Virology 49 21316727
2012 Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function. Molecular and cellular biology 46 22688513
2010 The ORF37 (UL24) is a neuropathogenicity determinant of equine herpesvirus 1 (EHV-1) in the mouse encephalitis model. Virology 45 20199788
2019 Survival of probiotic strain Lactobacillus paracasei L26 during co-fermentation with S. cerevisiae for the development of a novel beer beverage. Food microbiology 42 31027817
2010 Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin. Journal of virology 42 19864385
2020 Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65. Viruses 39 31906441
2008 The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin. The Journal of general virology 39 18420791
2006 Immune enhancing effects of Lactobacillus acidophilus LAFTI L10 and Lactobacillus paracasei LAFTI L26 in mice. International journal of food microbiology 38 17134782
2002 The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are tegument components. The Journal of general virology 38 12029146
2006 Characterization of the genes encoding UL24, TK and gH proteins from duck enteritis virus (DEV): a proof for the classification of DEV. Virus genes 37 16972038
2006 Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease. Journal of virology 35 16474163
2009 Development and evaluation of an antigen-capture ELISA for detection of the UL24 antigen of the duck enteritis virus, based on a polyclonal antibody against the UL24 expression protein. Journal of virological methods 34 19467266
2009 The conserved UL24 family of human alpha, beta and gamma herpesviruses induces cell cycle arrest and inactivation of the cyclinB/cdc2 complex. Archives of virology 32 19526192
2008 Analysis of synonymous codon usage in the UL24 gene of duck enteritis virus. Virus genes 32 18958612
2005 Herpes simplex virus type 2 UL24 gene is a virulence determinant in murine and guinea pig disease models. Journal of virology 29 16051842
2021 Inhibition of the DNA-Sensing pathway by pseudorabies virus UL24 protein via degradation of interferon regulatory factor 7. Veterinary microbiology 28 33677368
2018 Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): Probiotics Able to Block the In Vitro Adherence of Rotavirus in MA104 Cells. Probiotics and antimicrobial proteins 27 28432676
2010 Differential importance of highly conserved residues in UL24 for herpes simplex virus 1 replication in vivo and reactivation. The Journal of general virology 27 20071482
2012 Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge. Veterinary research 26 22770566
2021 Pseudorabies virus UL24 antagonizes OASL-mediated antiviral effect. Virus research 25 33476694
1996 The BamHI fragment 9 of pseudorabies virus contains genes homologous to the UL24, UL25, UL26, and UL 26.5 genes of herpes simplex virus type 1. Virus research 25 8806172
1996 Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation. Virology 22 8615023
1994 Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas. American journal of clinical pathology 21 8085550
1994 Characterization of the bovine herpesvirus 1 homolog of the herpes simplex virus 1 UL24 open reading frame. Virology 21 8128626
1993 Differentiation of reactive from neoplastic small-cell lymphoid aggregates in paraffin-embedded marrow particle preparations using L-26 (CD20) and UCHL-1 (CD45RO) monoclonal antibodies. American journal of clinical pathology 21 7679873
2001 Identification and characterization of the UL24 gene product of herpes simplex virus type 2. Virus genes 20 11450950
1989 The primary structure of rat ribosomal protein L26. FEBS letters 20 2546830
1989 B cell associated monoclonal antibody L26 may occasionally label T cell lymphomas. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20 2590534
2001 Transcription pattern of ribosomal protein L26 during anoxia exposure in Littorina littorea. The Journal of experimental zoology 18 11748624
2016 p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Oncotarget 17 27825141
2022 CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth. Cell proliferation 16 35509151
2017 Influence of Lactobacillus reuteri L26 Biocenol™ on immune response against porcine circovirus type 2 infection in germ-free mice. Beneficial microbes 16 28504566
2013 The UL24 protein of herpes simplex virus 1 affects the sub-cellular distribution of viral glycoproteins involved in fusion. Virology 16 23876459
1980 Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11. Biochemistry 16 6773542
2015 Mutation of UL24 impedes the dissemination of acute herpes simplex virus 1 infection from the cornea to neurons of trigeminal ganglia. The Journal of general virology 14 25986633
2009 Cloning, expression, purification and characterization of UL24 partial protein of duck enteritis virus. Intervirology 14 19786809
2002 Nucleotide sequence of glycoprotein genes B, C, D, G, H and I, the thymidine kinase and protein kinase genes and gene homologue UL24 of an Australian isolate of canine herpesvirus. Virus genes 14 12416682
2023 Mechanism of herpesvirus UL24 protein regulating viral immune escape and virulence. Frontiers in microbiology 13 37808279
2014 Vaccination with a HSV-2 UL24 mutant induces a protective immune response in murine and guinea pig vaginal infection models. Vaccine 13 24462481
2018 Functional analysis of the UL24 protein of suid herpesvirus 1. Virus genes 12 30478778
2017 Duck enteritis virus (DEV) UL54 protein, a novel partner, interacts with DEV UL24 protein. Virology journal 12 28851454
2010 Relocalization of upstream binding factor to viral replication compartments is UL24 independent and follows the onset of herpes simplex virus 1 DNA synthesis. Journal of virology 12 20147409
2016 DsRNA-mediated targeting of ribosomal transcripts RPS6 and RPL26 induces long-lasting and significant reductions in fecundity of the vector Aedes aegypti. Journal of insect physiology 11 27180677
1998 Isolation of a cDNA encoding a homologue of ribosomal protein L26 in the decapod crustacean Penaeus japonicus. Molecular marine biology and biotechnology 11 9892715
1996 Differential diagnosis of L26-positive, CD15-negative Hodgkin's disease and large B-cell lymphoma with a high content of reactive T-cells: a morphologic and immunohistochemical study. Hematopathology and molecular hematology 10 8878732
2018 A Mutation in the UL24 Gene Abolishes Expression of the Newly Identified UL24.5 Protein of Herpes Simplex Virus 1 and Leads to an Increase in Pathogenicity in Mice. Journal of virology 9 30068651
1996 Differential regulation of the murine ribosomal protein L26 gene in macrophage activation. Life sciences 9 8538365
1994 The clinical relevance of L26, a B-cell-specific antibody, in Hodgkin's disease. American journal of clinical oncology 9 7514847
2011 Molecular data of UL24 homolog gene (ORF37) from Brazilian isolates of equine herpesvirus type 1. Research in veterinary science 8 21684566
1997 Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1. Virus genes 8 9208458
1991 Thymoma with abundant L26-positive 'asteroid' cells. A case report with an analysis of normal thymus and thymoma specimens. Archives of pathology & laboratory medicine 7 1768216
2024 Duck plague virus UL24 protein initiates K48/K63-linked IRF7 polyubiquitination to antagonize the innate immune response. Poultry science 6 39418790
2024 Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation. Viruses 6 39459934
1998 Yeast ribosomal protein L26 is located at the ribosomal subunit interface as determined by chemical cross-linking. Biochimie 6 9672752
1993 Strong expression of L26 antigen in epithelial cells of human neonatal thymus. An immunohistochemical study using light and electron microscopy. Thymus 6 7687799
2023 Novel O-benzylcinnamic acid derivative L26 treats acute lung injury in mice by MD-2. European journal of medicinal chemistry 5 36963290
2023 Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA. Molecular therapy. Methods & clinical development 5 37519407
2023 UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc. American journal of cancer research 5 37693154
2021 The Use of B-Cell Polysome Profiling to Validate Novel RPL5 (uL18) and RPL26 (uL24) Variants in Diamond-Blackfan Anemia. Journal of pediatric hematology/oncology 5 33122585
2019 Force measurements show that uL4 and uL24 mechanically stabilize a fragment of 23S rRNA essential for ribosome assembly. RNA (New York, N.Y.) 5 30705137
2018 Systemic immune response of gnotobiotic mice infected with porcine circovirus type 2 after administration of Lactobacillus reuteri L26 Biocenol™. Beneficial microbes 5 30232907
1992 Sulfhydryl groups on yeast ribosomal proteins L7 and L26 are significantly more reactive in the 80 S particles than in the 60 S subunits. The Journal of biological chemistry 5 1733947
2024 UL24 herpesvirus determinants of pathogenesis: Roles in virus-host interactions. Virology 4 39765022
2023 The Disruption of a Nuclear Export Signal in the C-Terminus of the Herpes Simplex Virus 1 Determinant of Pathogenicity UL24 Protein Leads to a Syncytial Plaque Phenotype. Viruses 4 37766377
2022 Human Cytomegalovirus UL24 and UL43 Cooperate to Modulate the Expression of Immunoregulatory UL16 Binding Protein 1. Viral immunology 4 36179070
2022 Human cytomegalovirus UL24 and UL43 products participate in SAMHD1 subcellular localization. Virusdisease 4 36447815
2014 The ribosomal protein rpl26 promoter is required for its 3' sense terminus ncRNA transcription in Schizosaccharomyces pombe, implicating a new transcriptional mechanism for ncRNAs. Biochemical and biophysical research communications 4 24434141
2002 Comparison of six Australian isolates of Bovine herpes virus 2 based on UL24 gene after a passage in MDBK cells. Acta virologica 3 12580380
2024 RPL26 variants: A rare cause of Diamond-Blackfan anemia syndrome with multiple congenital anomalies at the forefront. Genetics in medicine : official journal of the American College of Medical Genetics 2 39268718
2024 Comparative Review of the Conserved UL24 Protein Family in Herpesviruses. International journal of molecular sciences 2 39457049
2024 Familial RPL26 Variant Causing Congenital Anomalies Without Hematological Features of Diamond Blackfan Anemia. American journal of medical genetics. Part A 2 39710607
2015 Similar regulation of two distinct UL24 promoters by regulatory proteins of equine herpesvirus type 1 (EHV-1). FEBS letters 2 25937123
2026 UL24 deletion attenuates Marek's disease virus replication and pathogenicity. Veterinary microbiology 1 41610489
2025 The UL24 gene affects duck plague virus replication, and its deletion attenuates virulence, enabling use as a vaccine. Poultry science 1 40974994
2023 RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum. bioRxiv : the preprint server for biology 1 36945571
2005 Recovery of cDNAs encoding ribosomal proteins S9 and L26 from Aedes albopictus mosquito cells and identification of their homologs in the malaria vector, Anopheles gambiae. Archives of insect biochemistry and physiology 1 16116622
2026 Long Non-Coding RNA RAB11B-AS1 Suppresses Cervical Cancer Progression by Upregulating RPL26 Expression. Frontiers in bioscience (Landmark edition) 0 41609088
2026 RPL26 UFMylation deficiency triggers Paneth cell apoptosis associated with ER stress by impairing ATG16L1-dependent ER-phagy. Cellular signalling 0 41962728
2025 Integrated multi-omics analysis and functional validation uncovers RPL26 roles in regulating growth traits of Asian water buffaloes (Bubalus bubalis). BMC genomics 0 40340823

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