Affinage

RPL14

Large ribosomal subunit protein eL14 · UniProt P50914

Length
215 aa
Mass
23.4 kDa
Annotated
2026-06-10
59 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL14 (eL14) is an essential structural protein of the eukaryotic 60S large ribosomal subunit, first isolated biochemically from rat liver ribosomes (PMID:621213) and later defined in human as a 220-amino-acid protein bearing nuclear targeting sequences, an rRNA-binding element, and a C-terminal polyalanine tract (PMID:9480843). The protein adopts a five-stranded beta-barrel with discrete RNA- and protein-binding surface patches, including a hydrophobic patch implicated in contacting L19 (PMID:8805509), a functional L14–L19 interaction independently supported by compensatory-evolution genetics in which L14 mutations rescue the fitness costs of L19 mutations and influence translational decoding (PMID:17157877). During ribosome biogenesis, L14 assembles early in the nucleolus into pre-60S particles; its depletion blocks processing of 27SA2/27SA3 to 27SB pre-rRNA, triggers turnover of 27S precursors, prevents pre-60S export, and reduces loading of neighboring ribosomal proteins at the solvent interface and polypeptide exit tunnel, while removal of its eukaryote-specific C-terminal extension alters translation fidelity (PMID:29788267). Consistent with this essential role, RPL14 is dosage-sensitive: haploinsufficiency in Drosophila produces a Minute phenotype and RNAi knockdown below ~50% causes lethality and developmental anomalies (PMID:9236770, PMID:14597387). Beyond ribosome assembly, PRMT5 binds RPL14 and catalyzes symmetric arginine dimethylation that stabilizes the protein, promotes DNA damage repair, and confers regorafenib resistance in hepatocellular carcinoma (PMID:40115921), and RPL14 overexpression suppresses proliferation, migration, invasion, and EMT in nasopharyngeal carcinoma cells (PMID:34057029).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1978 High

    Established RPL14 as a bona fide protein constituent of the eukaryotic 60S large ribosomal subunit, providing the foundational identity for all downstream work.

    Evidence Ion-exchange and gel-filtration purification from native rat liver 60S subunits with SDS-PAGE and amino acid composition analysis

    PMID:621213

    Open questions at the time
    • No structural or functional role assigned beyond subunit membership
    • No information on assembly stage or rRNA contacts
  2. 1978 Medium

    Showed that L14 is a target of metabolically regulated phosphorylation, raising the question of post-translational control of ribosomal proteins.

    Evidence Radiolabeled phosphorylation assays in Krebs II ascites cells under varying metabolic conditions

    PMID:27217

    Open questions at the time
    • Responsible kinase and phosphosites not identified
    • Functional consequence of phosphorylation unknown
  3. 1989 High

    Defined how L14 synthesis is controlled in bacteria, showing translational/mRNA-stability retroregulation by S8 rather than autonomous regulation.

    Evidence Genetic site mutations, S8 overexpression in trans, and exonuclease-deficient strains in E. coli spc operon

    PMID:2643112

    Open questions at the time
    • Bacterial operon regulation does not extend to eukaryotic RPL14
    • No direct test of S8–L14 mRNA contact in vivo structure
  4. 1994 Medium

    Identified a candidate transcription factor (FIII/YY1) binding the RPL14 promoter first exon, addressing how the gene might be transcriptionally controlled.

    Evidence cDNA cloning, oocyte overexpression, immunological characterization, and DNA-binding assays in Xenopus

    PMID:7802655

    Open questions at the time
    • Binding alone did not establish a regulatory role
    • No demonstration of effect on transcription
  5. 1996 High

    Provided the atomic-level architecture of L14, defining the beta-barrel fold and mapping the surfaces that mediate rRNA contacts and a putative L19 interaction.

    Evidence X-ray crystallography (isomorphous replacement/MAD) of L14 from Bacillus stearothermophilus with surface patch analysis

    PMID:8805509

    Open questions at the time
    • Bacterial structure lacks the eukaryote-specific C-terminal extension
    • L19 interaction proposed from surface analysis, not directly co-crystallized
  6. 1996 Medium

    Characterized the human RPL14 transcript and protein, defining domains including nuclear targeting sequences, an rRNA-binding element, and a polyalanine tract.

    Evidence cDNA cloning/sequencing from a human endothelial library with Northern blot and bioinformatic domain analysis

    PMID:9480843

    Open questions at the time
    • No functional assays of the predicted domains
    • Role of the polyalanine tract unknown
  7. 1997 High

    Demonstrated that RPL14 is haploinsufficient and dosage-sensitive in a metazoan, linking reduced gene dosage to a defined developmental Minute phenotype.

    Evidence Drosophila P-element insertion with quantitative Northern blot and P-element remobilization rescue

    PMID:9236770

    Open questions at the time
    • Molecular basis of the Minute phenotype at the ribosome level not resolved
    • No human disease link established here
  8. 1998 Medium

    Resolved the FIII/YY1 question with a negative result, showing the binding sites are dispensable for RPL14 promoter activity.

    Evidence CAT reporter assays with mutated FIII/YY1 sites in Xenopus oocytes and kidney cells plus FIII/YY1 overexpression

    PMID:9738894

    Open questions at the time
    • Actual cis-elements driving RPL14 transcription not identified
    • Limited to Xenopus reporter systems
  9. 2002 Medium

    Identified RPL14 as an SLE-specific autoantigen, raising the question of why a ribosomal protein becomes immunogenic in autoimmunity.

    Evidence 2D gel/immunoblot antigen identification and recombinant GST-L14 immunoblotting against 126 SLE and 212 control sera

    PMID:12051391

    Open questions at the time
    • Mechanism of immunogenicity unexplored
    • No causal link between autoantibody and disease pathology
  10. 2003 High

    Confirmed that RPL14 is essential for viability and proliferation when reduced below ~50%, reinforcing its dosage-critical role across tissues.

    Evidence Spatiotemporal GAL4/UAS RNAi knockdown in Drosophila with RNA-level verification and phenotypic analysis

    PMID:14597387

    Open questions at the time
    • Did not distinguish ribosome-assembly defects from extra-ribosomal effects
    • No molecular pathway dissection
  11. 2006 High

    Provided functional genetic evidence for the L14–L19 interaction predicted structurally, linking it to translational decoding accuracy.

    Evidence Compensatory-evolution serial passage in Salmonella with fitness, UGA read-through, and aminoglycoside sensitivity assays

    PMID:17157877

    Open questions at the time
    • Bacterial context; eukaryotic L14–L19 contact not directly tested here
    • Mechanism of decoding modulation not resolved at atomic level
  12. 2018 High

    Placed eL14 in the ribosome biogenesis pathway, showing it acts early in nucleolar pre-60S assembly to drive 27S pre-rRNA processing, pre-60S export, and neighbor-protein loading, with the C-terminal extension tuning translation fidelity.

    Evidence Conditional depletion in S. cerevisiae with Northern blot of pre-rRNA intermediates, sucrose gradient sedimentation, factor co-sedimentation, and C-terminal truncation mutants

    PMID:29788267

    Open questions at the time
    • Direct structural snapshot of eL14 within human pre-60S not provided
    • Precise mechanism by which the C-terminal extension affects fidelity unresolved
  13. 2021 Medium

    Linked RPL14 levels to cancer cell behavior, showing overexpression suppresses proliferation, migration, invasion, and EMT in nasopharyngeal carcinoma.

    Evidence Gain-of-function transfection with CCK-8, colony formation, cell cycle, transwell, and EMT-marker Western blots

    PMID:34057029

    Open questions at the time
    • No rescue or epistasis to place RPL14 in a defined pathway
    • Single tumor type; mechanism of EMT suppression unknown
  14. 2025 Medium

    Revealed an extra-ribosomal regulatory axis: PRMT5-catalyzed symmetric arginine dimethylation stabilizes RPL14 and couples it to DNA damage repair and chemoresistance.

    Evidence Mass spectrometry, co-immunoprecipitation, siRNA knockdown, PRMT5 overexpression, and γ-H2AX/RAD51 Western blot/immunofluorescence in hepatocellular carcinoma cells

    PMID:40115921

    Open questions at the time
    • Specific methylated arginine residues not mapped
    • Mechanistic link between RPL14 and RAD51-mediated repair undefined
    • Single lab and single tumor model

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPL14's structural role in 60S assembly mechanistically connects to its extra-ribosomal functions in DNA damage repair, EMT regulation, and chemoresistance remains unresolved.
  • No structure of human eL14 within the assembled ribosome or pre-60S
  • Unknown whether cancer phenotypes arise from altered translation or moonlighting activity
  • PRMT5-dependent and ribosome-assembly functions not integrated in a single model

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0005198 structural molecule activity 3
Localization
GO:0005840 ribosome 2 GO:0005730 nucleolus 1
Pathway
R-HSA-392499 Metabolism of proteins 2 R-HSA-8953854 Metabolism of RNA 1
Partners
PRMT5RPL19
Complex memberships
60S large ribosomal subunitpre-60S particle

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 Crystal structure of ribosomal protein L14 from Bacillus stearothermophilus was solved, revealing a five-stranded beta-barrel, a C-terminal loop region with two small alpha-helices, and a beta-ribbon projecting from the barrel. Analysis identified three surface patches likely mediating L14-RNA and L14-protein interactions, with two RNA-binding sites and a hydrophobic patch proposed as an L19 protein-protein interaction site. X-ray crystallography using isomorphous replacement and MAD methods, solved to high resolution Structure (London, England : 1993) High 8805509
1978 Ribosomal protein L14 was purified from the 60S large ribosomal subunit of rat liver ribosomes, establishing it as a component of the eukaryotic 60S subunit with a defined molecular weight estimated by SDS-PAGE. Protein purification via ion-exchange chromatography (carboxymethylcellulose, DEAE-cellulose) and gel filtration; molecular weight by SDS-PAGE; amino acid composition analysis The Journal of biological chemistry High 621213
1978 Ribosomal protein L14 in Krebs II ascites cells becomes phosphorylated when cells are incubated in Eagle's medium (glucose + amino acids), a condition that also causes dephosphorylation of Lgamma, suggesting that metabolic state regulates the pattern of ribosomal protein phosphorylation. Radiolabeled phosphorylation assays in Krebs II ascites cells under varying metabolic conditions; comparison of phosphorylation patterns on ribosomal proteins Biochimica et biophysica acta Medium 27217
1989 In E. coli, ribosomal protein S8 retroregulates synthesis of L14 and L24 (the first and second gene products of the spc operon) by acting at an mRNA target site distal to the L14/L24 coding sequences; mRNA degradation by 3'-to-5' exonucleases (polynucleotide phosphorylase and RNase II) is the mechanism of this retroregulation. Genetic analysis using single-base substitutions in the S8 target site; S8 overexpression in trans from a plasmid; temperature-sensitive mutations in polynucleotide phosphorylase and RNase II genes; differential synthesis rate measurements Proceedings of the National Academy of Sciences of the United States of America High 2643112
2006 Compensatory evolution experiments in Salmonella typhimurium revealed that mutations in L14 can compensate for fitness costs of L19 mutations, demonstrating a functional interaction between L14 and L19 in the 50S subunit. L14 is located close to L19, and their interaction with 16S rRNA may influence 30S subunit function during the decoding step of translation. In vivo fitness measurements, serial passage for compensatory evolution, translation speed and accuracy assays (UGA read-through), aminoglycoside sensitivity testing, genetic epistasis Journal of molecular biology High 17157877
2018 In Saccharomyces cerevisiae, L14 (eL14) assembles in the nucleolus at an early stage into pre-60S particles. Depletion of L14 causes defective processing of 27SA2 and 27SA3 to 27SB pre-rRNAs, leads to turnover of 27S pre-rRNAs, blocks export of pre-60S particles, and reduces association of neighboring ribosomal proteins at the solvent interface and around the polypeptide exit tunnel. Removal of the distal eukaryote-specific C-terminal extensions of L14 and L16 causes slight translation alterations in mature 60S subunits. Conditional depletion of L14; Northern blot analysis of pre-rRNA processing intermediates; sucrose gradient sedimentation; co-sedimentation of trans-acting factors; C-terminal truncation mutants analyzed for translation fidelity Nucleic acids research High 29788267
1997 Haploinsufficiency of the Drosophila RPL14 gene (caused by a P-element insertion in the RPL14 promoter region) causes a strong Minute phenotype (short thin bristles, developmental delay, recessive lethality), establishing RPL14 as a dosage-sensitive ribosomal protein gene. Quantitative Northern blot showed reduction in RPL14 mRNA; remobilization of the P element restored wild-type RPL14 mRNA levels and normal phenotype. P-element mutagenesis; quantitative Northern blot; P-element remobilization rescue experiment; phenotypic analysis Molecular & general genetics : MGG High 9236770
2003 Targeted RNA interference (RNAi) knockdown of Drosophila RpL14 using the GAL4/UAS system causes lethality and distinct somatic anomalies in both developing and differentiated cells, demonstrating that RPL14 is essential for normal cell proliferation and development when reduced below 50% of normal levels. Heritable RNAi via GAL4/UAS binary system; RNA-level confirmation of knockdown; phenotypic analysis of developing and differentiated tissues Gene High 14597387
1994 The transcription factor FIII/YY1 (Xenopus homolog of human YY1/delta) binds to the first exon of the Xenopus laevis ribosomal protein L14 gene. The protein was identified to share antigenic and DNA-binding properties with the endogenous oocyte protein that contacts the first exon of rp genes L1 and L14. cDNA cloning; overexpression in Xenopus oocytes; immunological characterization; DNA-binding assays Biochemical and biophysical research communications Medium 7802655
1998 FIII/YY1 binding sites in the first exon of Xenopus laevis RPL14 (and L1) promoters are dispensable for promoter expression: mutations in the FIII/YY1 sites did not change reporter (CAT) activity in oocyte injection assays or in transfected Xenopus kidney cells, and overexpression of FIII/YY1 had no effect. CAT reporter assays with wild-type and mutated FIII/YY1 binding sites; oocyte microinjection; cell transfection; FIII/YY1 overexpression European journal of biochemistry Medium 9738894
1996 Human RPL14 (hRL14) encodes a 60S ribosomal subunit protein of 220 amino acids (predicted MW 23.6 kDa) containing nuclear targeting sequences, a bZIP-like element for rRNA binding, and internal pentapeptide repeat sequences. The COOH-terminal region contains 15 GCT (alanine) triplet repeats encoding a polyalanine tract. cDNA cloning and sequencing from human endothelial cell library; Northern blot analysis; bioinformatic domain analysis Biochemical and biophysical research communications Medium 9480843
2025 PRMT5 interacts with RPL14 and catalyzes symmetric dimethylation of RPL14 at arginine residues. This modification stabilizes RPL14 protein, promotes DNA damage repair (as measured by RAD51 expression), and contributes to regorafenib resistance in hepatocellular carcinoma cells. RPL14 knockdown increases DNA damage (γ-H2AX), reduces cell viability, and increases sensitivity to regorafenib. Mass spectrometry; co-immunoprecipitation; Western blot for γ-H2AX and RAD51; lentiviral PRMT5 overexpression; siRNA knockdown; immunofluorescence Journal of gastrointestinal oncology Medium 40115921
2021 RPL14 overexpression in nasopharyngeal carcinoma (NPC) cells represses cell proliferation (blocking cells in S phase), migration, invasion, and the epithelial-mesenchymal transition (EMT) process, as evidenced by altered expression of E-cadherin, N-cadherin, and vimentin. CCK-8 assay; colony formation assay; cell cycle analysis; transwell migration/invasion assay; Western blot for EMT markers; overexpression via transfection Bioengineered Medium 34057029
2002 Autoantibodies against ribosomal protein L14 are specifically detected in sera from patients with systemic lupus erythematosus (SLE) but not in patients with dermatomyositis/polymyositis, systemic sclerosis, or healthy controls, identified using GST-L14 fusion protein as antigen. Immunoblotting of total ribosomal proteins; 2D gel electrophoresis with immunoblotting for antigen identification; immunoblotting with recombinant GST-L14 fusion protein against 126 SLE and 212 control sera Clinical and experimental rheumatology Medium 12051391

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development (Cambridge, England) 197 8306885
1994 Selective modulation of the interaction of alpha 7 beta 1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation. Journal of cell science 153 8175907
1994 Rat olfactory neurons can utilize the endogenous lectin, L-14, in a novel adhesion mechanism. Development (Cambridge, England) 137 8050350
1992 Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre- and post-implantation development. Development (Cambridge, England) 137 1638977
1978 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins La, Lb, Lf, P1, P2, L13', L14, L18', L20, and L38. The Journal of biological chemistry 112 621213
1993 L-14 lectin recognition of laminin and its promotion of in vitro cell adhesion. Archives of biochemistry and biophysics 104 8380972
2020 Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the Toll-Like Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells. International journal of molecular sciences 65 33291425
1996 The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus. Structure (London, England : 1993) 59 8805509
1989 Retroregulation of the synthesis of ribosomal proteins L14 and L24 by feedback repressor S8 in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 52 2643112
2021 Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2- and AMPK-mediated obesity-associated disorders in high-fat-diet-induced obese C57BL/6J mice. Cell proliferation 51 33830560
1985 The complete primary structure of ribosomal proteins L1, L14, L15, L23, L24 and L29 from Bacillus stearothermophilus. European journal of biochemistry 50 4018095
2006 Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19. Journal of molecular biology 49 17157877
1994 Characterization of FIII/YY1, a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes. Biochemical and biophysical research communications 38 7802655
2015 5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism. Archives of toxicology 37 25600587
1986 Sequences coding for the ribosomal protein L14 in Xenopus laevis and Xenopus tropicalis; homologies in the 5' untranslated region are shared with other r-protein mRNAs. Nucleic acids research 36 3774540
2015 Development of cellular hypertrophy by 8-hydroxyeicosatetraenoic acid in the human ventricular cardiomyocyte, RL-14 cell line, is implicated by MAPK and NF-κB. Cell biology and toxicology 33 26493311
1998 Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers. Mutation research 28 9920051
1997 The Drosophila ribosomal protein L14-encoding gene, identified by a novel Minute mutation in a dense cluster of previously undescribed genes in cytogenetic region 66D. Molecular & general genetics : MGG 28 9236770
2014 Human fetal ventricular cardiomyocyte, RL-14 cell line, is a promising model to study drug metabolizing enzymes and their associated arachidonic acid metabolites. Journal of pharmacological and toxicological methods 25 25454080
2005 Alteration of RPL14 in squamous cell carcinomas and preneoplastic lesions of the esophagus. Gene 25 16316724
1996 Cell-mediated immunity to pseudorabies virus: cytolytic effector cells with characteristics of lymphokine-activated killer cells lyse virus-infected and glycoprotein gB- and gC-transfected L14 cells. The Journal of general virology 25 8609496
1990 Analysis of NADH dehydrogenase proteins, ATPase subunit 9, cytochrome b, and ribosomal protein L14 encoded in the mitochondrial DNA of Paramecium. Nucleic acids research 24 2137906
1978 The phosphorylation of ribosomal proteins L14 and S3 in Krebs II ascites cells. Biochimica et biophysica acta 24 27217
2005 Effect of 2-(2-Pyridyl)azole-based ancillary ligands (L1-4) on the electrophilicity of the nitrosyl function in [RuII(trpy)(L1-)4)(NO)]3+ [trpy = 2,2':6',2' '-Terpyridine]. synthesis, structures, and spectroscopic, electrochemical, and kinetic aspects. Inorganic chemistry 23 15877432
1995 The single-ring Thermoanaerobacter brockii chaperonin 60 (Tbr-EL7) dimerizes to Tbr-EL14.Tbr-ES7 under protein folding conditions. Biochemistry 22 7578105
2021 Propofol Inhibits the Progression of Cervical Cancer by Regulating HOTAIR/miR-129-5p/RPL14 Axis. OncoTargets and therapy 21 33505161
2020 Anti-Cancer Effects of Lactobacillus plantarum L-14 Cell-Free Extract on Human Malignant Melanoma A375 Cells. Molecules (Basel, Switzerland) 21 32859054
2003 Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies. Gene 19 14597387
2023 Ameliorative Effects of Lactobacillus paracasei L14 on Oxidative Stress and Gut Microbiota in Type 2 Diabetes Mellitus Rats. Antioxidants (Basel, Switzerland) 18 37627510
1994 Expression of the soluble lectin L-14 gene is induced by TSH in thyroid cells and suppressed by retinoic acid in transformed neural cells. Biochemical and biophysical research communications 15 8135794
2016 Heterologous Expression and Delivery of Biologically Active Exendin-4 by Lactobacillus paracasei L14. PloS one 14 27764251
1998 Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). Biochemical and biophysical research communications 14 9480843
1996 The primary structure of rat ribosomal protein L14. Biochemical and biophysical research communications 14 8670222
2004 Discrimination among species of Papaver based on the plastid rpl16 gene and the rpl16-rpl14 spacer sequence. Forensic science international 13 15040916
1990 DXS28 (C7) maps centromeric to DXS68 (L1-4) and DXS67 (B24) by deletion analysis. Genomics 13 2163974
2023 Mitochondrial Ribosomal Protein L14 Promotes Cell Growth and Invasion by Modulating Reactive Oxygen Species in Thyroid Cancer. Clinical and experimental otorhinolaryngology 12 36822197
2022 Genomic and AntiSMASH Analyses of Marine-Sponge-Derived Strain Aspergillus niger L14 Unveiling Its Vast Potential of Secondary Metabolites Biosynthesis. Journal of fungi (Basel, Switzerland) 12 35736074
2021 Human/eukaryotic ribosomal protein L14 (RPL14/eL14) overexpression represses proliferation, migration, invasion and EMT process in nasopharyngeal carcinoma. Bioengineered 12 34057029
2018 Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae. Nucleic acids research 11 29788267
2002 Pharmacognostical studies of cistanchis herba (III) phylogenetic relationship of the cistanche plants based on plastid rps2 gene and rpl16-rpl14 intergenic spacer sequences. Biological & pharmaceutical bulletin 10 11853170
2004 Preferential expression of a HLP homolog encoding a mitochondrial L14 ribosomal protein in stamens of common wheat. Gene 9 15588583
1994 Xenopus laevis L-14 lectin is expressed in a typical pattern in the adult, but is absent from embryonic tissues. Glycobiology 9 7949655
2025 Ezetimibe Engineered L14-8 Suppresses Advanced Prostate Cancer by Activating PLK1/TP53-SAT1-Induced Ferroptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 40536697
2005 The sequences of the plastid gene rpl16 and the rpl16-rpl14 spacer region allow discrimination among six species of Scutellaria. Journal of ethnopharmacology 7 15848027
2020 Development of endomyocardial fibrosis model using a cell patterning technique: In vitro interaction of cell coculture of 3T3 fibroblasts and RL-14 cardiomyocytes. PloS one 6 32092082
2002 Autoantibody against ribosomal protein L14 in patients with systemic lupus erythematosus. Clinical and experimental rheumatology 6 12051391
1998 The binding sites for Xenopus laevis FIII/YY1 in the first exon of L1 and L14 ribosomal protein genes are dispensable for promoter expression. European journal of biochemistry 6 9738894
2023 The Effects of 16-HETE Enantiomers on Hypertrophic Markers in Human Fetal Ventricular Cardiomyocytes, RL-14 Cells. European journal of drug metabolism and pharmacokinetics 5 37815672
1994 Crystallization and preliminary X-ray diffraction studies of bacterial ribosomal protein L14. Acta crystallographica. Section D, Biological crystallography 5 15299380
2004 Molecular and immunological characterization of L14 ribosomal protein from Leishmania braziliensis. Parasitology 4 15030001
2022 In Vitro and in Vivo Activity of Lactobacillus Sakei L14 Strain Against Campylobacter Jejuni DC3 Strain. Journal of veterinary research 3 35582492
2025 PRMT5 attenuates regorafenib-induced DNA damage in hepatocellular carcinoma cells through symmetric dimethylation of RPL14. Journal of gastrointestinal oncology 2 40115921
2024 Overexpression of the Global Transcriptional Regulator LaeA Leads to Production of Cyclic Lipopeptides in Marine-Derived Aspergillus niger L14. Chemistry & biodiversity 2 39663999
2003 Identification and comparative analysis of the RpL14 gene from Takifugu rubripes. Hereditas 2 15061815
1997 Primary structure of Drosophila ribosomal protein L14 and identification of conserved protein motifs. DNA sequence : the journal of DNA sequencing and mapping 2 9522130
2026 Heat-Treated Culture-Dried Lactiplantibacillus plantarum L-14 Regulates Lipid Metabolism and Attenuates Diet-Induced Obesity in Adipose Tissue. Journal of medicinal food 0 41879162
2026 From Contact to Stalemate: MAPK-Associated Chemical and Enzymatic Defenses Shape a Stable Barrage in the Co-Culture of Trametes sp. D and Aspergillus niger L14. Journal of fungi (Basel, Switzerland) 0 42187809
2020 [Identification of Plant Fragments by Analyzing the Plastid rpl16-rpl14 Linker Sequences]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 0 32336715
2006 A novel full-length gene of human ribosomal protein L14.22 related to human glioma. Chinese medical journal 0 16934181

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