Affinage

RBMY1A1

RNA-binding motif protein, Y chromosome, family 1 member A1 · UniProt P0DJD3

Round 2 corrected
Length
496 aa
Mass
55.8 kDa
Annotated
2026-04-28
82 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RBMY1A1 is a Y-chromosome-encoded, germ cell-specific nuclear RNA-binding protein that functions as a regulator of pre-mRNA splicing during spermatogenesis. It directly interacts with SR family splicing factors and the SR-like activator Tra2beta through its SRGY box domains, serving as a tissue-specific cofactor whose depletion abolishes splicing of SR-dependent pre-mRNAs; its RRM domain recognizes RNA stem-loops via a dual-mode mechanism involving canonical beta-sheet surface contacts and a unique beta2-beta3 loop insertion into the RNA major groove (PMID:10823932, PMID:10749975, PMID:17318228). Loss of RBMY expression due to Y chromosome deletions results in germ cell arrest at early meiosis, consistent with an essential role in the transition to haploid spermatid development (PMID:9108067). In somatic and cancer contexts, the RBMY1A1 promoter is normally silenced by TRIM28-dependent DNA methylation—ectopic activation causes male-specific embryonic lethality—while aberrant cytoplasmic RBMY in hepatocellular carcinoma inhibits GSK3β to activate Wnt/β-catenin signaling and promote tumor stemness (PMID:28115466, PMID:26185016).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1993 High

    Identification of RBMY1A1 as a Y-linked, testis-specific RRM gene family deleted in infertile men established the first candidate gene for the azoospermia factor (AZF) locus and framed spermatogenesis as an RNA-processing-dependent process.

    Evidence cDNA cloning, Southern blot deletion mapping, RT-PCR of testis RNA in fertile vs. oligospermic men

    PMID:8269511

    Open questions at the time
    • No functional assay demonstrated a direct requirement for RBMY in germ cell development at this stage
    • Precise RNA targets and molecular function of the RRM domain were unknown
  2. 1997 High

    Protein-level analyses revealed that RBMY is a nuclear protein in male germ cells whose absence (via Y chromosome deletion) causes meiotic arrest before haploid differentiation, establishing a causal link between RBMY loss and spermatogenic failure.

    Evidence Immunohistochemistry across germ cell stages, Y chromosome deletion panel with defined testicular pathologies

    PMID:9108067

    Open questions at the time
    • Mechanism by which RBMY supports meiotic progression was not identified
    • Specific RNA substrates processed by RBMY in germ cells were unknown
  3. 1997 Medium

    Evolutionary analyses established that RBMY arose from autosomal/X-linked hnRNPG by transposition to the Y chromosome and subsequent amplification, with conservation of testis-specific expression across therian mammals spanning >130 million years.

    Evidence Comparative genomics and RT-PCR in marsupials and eutherians; RBMX identification on human X chromosome

    PMID:10391206 PMID:9020837

    Open questions at the time
    • Functional divergence between RBMY and its autosomal/X-linked homologues was not biochemically defined
    • Whether all ~30 Y-linked RBMY copies contribute to function was unclear
  4. 1998 High

    Dynamic subnuclear co-localization of RBMY with pre-mRNA splicing factors in spermatocytes, followed by dissociation in late meiosis, provided the first spatial evidence linking RBMY to the splicing machinery in a stage-dependent manner.

    Evidence Co-immunofluorescence of RBMY and splicing factor antibodies across spermatogenic stages

    PMID:9547301

    Open questions at the time
    • Co-localization does not prove direct interaction with splicing factors
    • Identity of specific splicing partners was not established
  5. 2000 High

    Biochemical reconstitution demonstrated that RBMY directly interacts with SR splicing factors and Tra2beta, and that the RBMY interaction domain can sequester active SR proteins to modulate pre-mRNA splicing in vitro, establishing RBMY as a germ cell-specific splicing co-regulator.

    Evidence Bacterial pull-down of SR proteins, depletion/add-back in vitro splicing assays, co-IP and immunofluorescence in spermatocytes, domain mapping

    PMID:10749975 PMID:10823932

    Open questions at the time
    • Endogenous pre-mRNA targets regulated by RBMY in germ cells were not identified
    • Whether RBMY activates or represses splicing of specific exons in vivo remained unclear
  6. 2007 High

    NMR structure of the RBMY RRM bound to its RNA target revealed a dual recognition mode—canonical beta-sheet/loop contacts plus a novel beta2-beta3 loop insertion into the RNA stem major groove—distinguishing RBMY from its paralog hnRNP G and explaining its unique RNA-binding specificity.

    Evidence SELEX identification of stem-loop RNA ligand; NMR structure determination of RRM-RNA complex

    PMID:17318228

    Open questions at the time
    • Whether the dual-mode recognition is functionally required for splicing regulation in germ cells was not tested
    • Genome-wide identification of endogenous RNA targets recognized by this structural mode was not performed
  7. 2015 High

    In hepatocellular carcinoma, RBMY was found to translocate to the cytoplasm via CRM1 and inhibit GSK3β by promoting its Ser9 phosphorylation, leading to β-catenin stabilization and Wnt-driven stemness, revealing a non-canonical cytoplasmic signaling function distinct from its nuclear splicing role.

    Evidence Co-IP, phosphorylation assays, xenograft tumor models, gain-of-function and loss-of-function experiments in HCC cell lines

    PMID:26185016

    Open questions at the time
    • Whether cytoplasmic RBMY retains RNA-binding activity or functions entirely as a protein–protein scaffold was not resolved
    • Relevance of this mechanism beyond hepatocellular carcinoma was not established
  8. 2017 High

    Genetic epistasis experiments revealed that TRIM28-dependent DNA methylation maintains RBMY1A1 promoter silencing in somatic/embryonic tissues; loss of this methylation causes ectopic RBMY activation and male-specific peri-implantation lethality, explaining the evolutionary pressure for epigenetic silencing outside the germline.

    Evidence Maternal Trim28 knockout mice, bisulfite sequencing of Rbmy1a1 promoter, embryo RNA expression and phenotyping

    PMID:28115466

    Open questions at the time
    • Downstream effectors of ectopic RBMY that cause lethality were not identified
    • Whether the lethal phenotype is mediated through splicing dysregulation or cytoplasmic signaling was not determined
  9. 2025 Medium

    RBMY1A1 was shown to direct sorting of miR-105-5p into exosomes in metastatic breast cancer, with exosomal miR-105-5p reprogramming fibroblasts into cancer-associated fibroblasts via LATS2 downregulation and NF-κB activation, extending RBMY's oncogenic roles to exosomal RNA sorting and tumor microenvironment remodeling.

    Evidence RBMY1A1 knockdown, exosome isolation, miRNA sequencing, fibroblast co-culture transformation assays, NF-κB reporter

    PMID:40151143

    Open questions at the time
    • Structural basis for RBMY-mediated miRNA sorting into exosomes was not determined
    • Whether RRM-dependent RNA recognition drives miRNA selection was not tested
    • Independent replication in additional cancer models is lacking

Open questions

Synthesis pass · forward-looking unresolved questions
  • The endogenous pre-mRNA targets of RBMY in spermatogenic cells remain unidentified genome-wide, and the mechanistic basis for how RBMY's splicing function in the nucleus relates to its cytoplasmic signaling and exosomal sorting activities in cancer is unresolved.
  • No CLIP-seq or equivalent transcriptome-wide mapping of RBMY RNA targets in germ cells has been reported
  • Structural basis for RBMY interaction with GSK3β versus SR proteins is unknown
  • Whether RBMY contributes to spermatogenic splicing programs through specific exon inclusion/skipping events has not been defined in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0003723 RNA binding 2
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 1
Pathway
R-HSA-8953854 Metabolism of RNA 3 R-HSA-1474165 Reproduction 2 R-HSA-162582 Signal Transduction 1
Partners
GSK3BKHDRBS3TRA2BXPO1

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 RBMY1A1 (YRRM/RBM) was identified as a Y-chromosome gene family encoding proteins with RNA recognition motifs, expressed specifically in the testis, with deletions detected in oligospermic patients, establishing it as a candidate for the azoospermia factor (AZF) controlling spermatogenesis. cDNA cloning, Southern blot analysis, interphase in situ hybridization, RT-PCR of testis RNA, deletion mapping in infertile patients Cell High 8269511
1997 RBM (RBMY1A1) protein is a nuclear protein expressed in fetal, prepubertal, and adult male germ cells. Its distribution correlates with transcriptional activity during spermatogenesis. Deletion mapping using anti-RBM antiserum identified a critical Y chromosome region whose loss abolishes RBM expression; in the absence of RBM expression, germ cell development arrests at early meiosis and does not proceed into the haploid phase. Immunohistochemistry with anti-RBM antiserum, deletion mapping panel of men with Y chromosome deletions and known testicular pathologies Proceedings of the National Academy of Sciences of the United States of America High 9108067
1997 RBM1 (RBMY1A1) is conserved and amplified on the marsupial Y chromosome with testis-specific transcription, suggesting it evolved from hnRNPG at least 130 million years ago through transposition to the Y chromosome and subsequent internal amplification, implying a critical male-specific function retained through evolution. Comparative genomics, Southern blot, RT-PCR of marsupial testis RNA, phylogenetic analysis Nature genetics Medium 9020837
1997 The RBMY gene family contains approximately 30 members on the Y chromosome, but only the RBMI subfamily (including RBMY1A1) is actively transcribed and encodes functional proteins. Alternative splicing generates protein isoforms with three or four SRGY boxes, increasing the complexity of the expressed products. RT-PCR, cDNA cloning and sequencing, characterization of multiple RBMY cDNA clones Genomics Medium 9344660
1998 RBMY1A1 (RBM) protein has a complex and dynamic subnuclear localization in human germ cells, distributed between punctate nuclear structures and the nucleoplasm in a developmentally regulated manner. Pre-mRNA splicing components co-localize with RBM in punctate nuclear regions during early spermatogenesis but dissociate late in meiosis, suggesting dynamic and possibly multiple functions for RBM in germ cell development. Immunofluorescence microscopy with anti-RBM antibodies, co-localization with splicing factor antibodies across germ cell developmental stages Journal of cell science High 9547301
1998 The genomic structure of an RBM gene (related to RBMY1A1) was determined: a 15-kb segment comprising 12 exons and 11 introns with high homology among exons VII-X (encoding SRGY boxes) and among introns VI-IX, consistent with origin from common ancestral sequences by internal amplification. P1 genomic library screening, cosmid subcloning, restriction mapping, DNA sequencing, RT-PCR of testis RNA The Journal of clinical endocrinology and metabolism Medium 8964845
1998 RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene, supporting a transposition-amplification model for RBMY gene family evolution. Comparative genomic and sequence analysis Nature genetics Medium 10391207
1998 The RBMY gene family structure and organization on the Y chromosome was characterized: seven RBMY genes in interval 6, four with normal 12-exon/15-kb structure, one pseudogene lacking the first 3 exons, and two belonging to a subfamily resembling ancestral hnRNPG with only one SRGY repeat; most RBMY genes in interval 6 are arranged in tandem. This supports the transposition-amplification hypothesis for RBMY evolution from an autosomal hnRNPG gene. Genomic cloning, restriction mapping, sequencing of RBMY genes from YAC clones Genomics Medium 9598316
1999 RBMY1A1 (RBM) protein interacts with T-STAR (a novel SAM68-related RNA-binding protein expressed primarily in testis) via yeast two-hybrid screen. T-STAR co-localizes with RBM in germ cells and is regulated during meiosis, suggesting that RBM and T-STAR/SAM68 participate in a common RNA-processing pathway in male germ cells. Yeast two-hybrid screen of testis cDNA library, cDNA cloning, chromosomal mapping, GFP transfection and nuclear localization studies Human molecular genetics Medium 10332027
1999 RBMY1A1 has a homologue on the human X chromosome (RBMX), indicating that RBMY evolved from an ancestral X-Y identical gene. Comparative genomic analysis, sequence characterization Nature genetics Medium 10391206
2000 RBMY1A1 (RBM) protein directly interacts with SR family splicing factors and with itself (self-interaction). The protein domains mediating these interactions were mapped, and a bacterially expressed RBM interaction region pulls down functionally active SR proteins from cell extracts. Depletion/add-back experiments showed that SR proteins bound by RBM are required for splicing of a panel of pre-mRNAs, establishing RBM as a germ cell-specific cofactor for SR protein-dependent pre-mRNA splicing. Protein-protein interaction assays, domain mapping, bacterial fusion protein expression, pull-down from cell extracts, depletion and add-back splicing experiments Proceedings of the National Academy of Sciences of the United States of America High 10823932
2000 RBMY1A1 (RBM) and other hnRNP G family proteins interact with Tra2beta (an SR-like splicing activator highly expressed in testis). Phosphorylation enhances this interaction and reduces competing RNA binding. RBM and Tra2beta co-localize in two major domains in human spermatocyte nuclei. Incubation with the RBM protein interaction domain inhibits splicing in vitro of a pre-mRNA substrate containing a Tra2beta-dependent enhancer, and the RBM RNA-binding domain affects 5' splice site selection. Co-immunoprecipitation, in vitro splicing inhibition assay, immunofluorescence co-localization in human spermatocytes, domain interaction mapping, phosphorylation experiments Human molecular genetics High 10749975
2004 RBMY1A1 (RBMY) and related proteins (hnRNP G-T, T-STAR) are part of a network of RNA-processing regulatory interactions involving SR proteins and signal transduction pathways, with RBMY providing a germ cell-specific component for pre-mRNA splicing regulation important for normal germ cell development. Review of protein interaction network data, yeast two-hybrid, co-IP studies International journal of andrology Low 15595951
2007 The RBMY1A1 RRM (RNA recognition motif) domain recognizes RNA stem-loops capped by a C(A)/(U)CAA pentaloop with high affinity. NMR structure determination of the hRBMY RRM in complex with target RNA revealed two distinct binding modes: (1) the RRM beta-sheet surface contacts the RNA loop in a sequence-specific manner (conserved with hnRNP G), and (2) uniquely to hRBMY, the beta2-beta3 loop inserts into the major groove of the RNA stem—a novel recognition mode not found in the paralogous hnRNP G. SELEX (systematic evolution of ligands by exponential enrichment), NMR structural determination of protein-RNA complex EMBO reports High 17318228
2002 CIRP (cold-inducible RNA-binding protein), which is structurally highly similar to RBM1 (RBMY1A1), is expressed in mouse germ cell nuclei (particularly primary spermatocytes) and its expression is down-regulated at elevated temperatures, potentially linking temperature-sensitive spermatogenesis to RNA-binding protein function in germ cells. Immunohistochemistry, RT-PCR, cell culture temperature experiments, experimental cryptorchidism model The American journal of pathology Low 9422546
2015 RBMY acts as a novel inhibitor of glycogen synthase kinase 3β (GSK3β): cytoplasmic RBMY binds to and increases Ser9 phosphorylation-mediated inactivation of GSK3β, thereby impeding GSK3β-dependent degradation of β-catenin, leading to nuclear β-catenin accumulation and transcription of downstream oncogenes. This promotes tumor stemness, self-renewal, chemoresistance, and cell-cycle progression in hepatocellular carcinoma cells. Cytoplasmic translocation of RBMY is mediated by binding to the nuclear exporter CRM1 and is enhanced by Wnt-3a stimulation. Co-immunoprecipitation, phosphorylation assays, xenograft tumor growth, loss-of-function and gain-of-function experiments, cell-cycle analysis, Western blot, immunohistochemistry Hepatology (Baltimore, Md.) High 26185016
2017 The Y-linked gene Rbmy1a1 is highly methylated in mature sperm and resists DNA demethylation post-fertilization. Aberrant hypomethylation of the Rbmy1a1 promoter (caused by loss of maternal TRIM28) results in ectopic activation of Rbmy1a1, causing male-specific peri-implantation lethality. Rbmy1a1 is a novel target of the TRIM28 complex, which protects its repressive epigenetic state during embryonic epigenetic reprogramming. Mouse genetic knockout (maternal Trim28 deletion), bisulfite sequencing, RNA expression analysis, embryo phenotyping Genes & development High 28115466
2025 RBMY1A1-dependent sorting of miR-105-5p into exosomes from highly metastatic breast cancer cells facilitates the transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs), which subsequently activates NF-κB signaling by downregulating LATS2 and promotes EMT of breast cancer cells. Exosome isolation, miRNA sequencing, loss-of-function (RBMY1A1 knockdown), co-culture fibroblast transformation assays, Western blot, NF-κB reporter assays Acta biochimica et biophysica Sinica Medium 40151143

Source papers

Stage 0 corpus · 82 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 1538 12815422
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2011 Global landscape of HIV-human protein complexes. Nature 593 22190034
2015 Widespread macromolecular interaction perturbations in human genetic disorders. Cell 454 25910212
1993 A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell 440 8269511
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics 222 17207965
2011 Next-generation sequencing to generate interactome datasets. Nature methods 200 21516116
1997 Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm. Proceedings of the National Academy of Sciences of the United States of America 200 9108067
2019 Network-based prediction of protein interactions. Nature communications 184 30886144
2004 A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Genomics 161 15177557
2002 hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1. Human molecular genetics 160 12165565
1994 PCR analysis of the Y chromosome long arm in azoospermic patients: evidence for a second locus required for spermatogenesis. Human molecular genetics 155 7661932
2002 Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas. The American journal of pathology 112 12213721
2000 RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. Human molecular genetics 104 10749975
1996 Microdeletions in interval 6 of the Y chromosome detected by STS-PCR in 6 of 33 patients with idiopathic oligo- or azoospermia. Cytogenetics and cell genetics 103 8978761
1999 The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome. Nature genetics 99 10391206
1998 Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. The American journal of pathology 99 9422546
1999 T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Human molecular genetics 97 10332027
2010 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Molecular & cellular proteomics : MCP 93 21044950
1997 A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome. Nature genetics 88 9020837
2003 Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice. Cancer research 84 12782601
2007 The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. EMBO reports 80 17318228
1998 Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development. Journal of cell science 75 9547301
2000 Deletion of Y-chromosome specific genes in human prostate cancer. The Journal of urology 69 10737540
2010 Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility? Journal of biomedicine & biotechnology 68 20671934
1997 Multiple functional copies of the RBM gene family, a spermatogenesis candidate on the human Y chromosome. Genomics 66 9344660
1996 The Y chromosome region essential for spermatogenesis. Hormone research 62 8864744
2018 An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Nature genetics 61 29892012
2019 Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Nature communications 60 31515488
2015 RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma. Hepatology (Baltimore, Md.) 58 26185016
2004 The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. International journal of andrology 58 15595951
2000 A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. Proceedings of the National Academy of Sciences of the United States of America 55 10823932
2010 The process of a Y-loss event in an XO/XO mammal, the Ryukyu spiny rat. Chromosoma 54 20443119
1999 RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Nature genetics 54 10391207
2006 RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway. The Journal of biological chemistry 53 17001072
1998 Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. Genomics 49 9598316
2010 Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines. The Journal of bone and joint surgery. American volume 42 20048108
2002 Gene-based screening for Y chromosome deletions in Taiwanese men presenting with spermatogenic failure. Fertility and sterility 42 12009341
1998 Y chromosome microdeletions, in azoospermic or near-azoospermic subjects, are located in the AZFc (DAZ) subregion. Molecular human reproduction 41 9733433
2008 MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. Clinical & experimental metastasis 28 18709334
1997 Dicentric Y chromosome in an azoospermic male. Molecular human reproduction 28 9294856
1997 Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene. Journal of medical genetics 28 9391878
2013 Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells. The Journal of organic chemistry 26 23679346
2020 HCoV-NL63 and SARS-CoV-2 Share Recognized Epitopes by the Humoral Response in Sera of People Collected Pre- and during CoV-2 Pandemic. Microorganisms 24 33327507
2017 Loss of maternal Trim28 causes male-predominant early embryonic lethality. Genes & development 24 28115466
2015 Hypermethylation of genes in testicular embryonal carcinomas. British journal of cancer 21 26625006
2002 Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model. The Journal of urology 21 12131367
1996 Genomic structure of a Y-specific ribonucleic acid binding motif-containing gene: a putative candidate for a subset of male infertility. The Journal of clinical endocrinology and metabolism 18 8964845
2019 Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB. Molecular oral microbiology 15 31056830
2003 Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. Journal of andrology 15 12954656
2007 Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice. International journal of oncology 14 17332933
2007 Male infertility: polymerase chain reaction-based deletion mapping of genes on the human chromosome. Singapore medical journal 14 18043844
1990 A monoclonal antibody, RbM2, specific for a lysosomal membrane antigen of rabbit monocyte/macrophages. Immunology 11 2203677
2022 Oligomerization of the FliF Domains Suggests a Coordinated Assembly of the Bacterial Flagellum MS Ring. Frontiers in microbiology 10 35087486
2012 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorganic & medicinal chemistry 10 22537678
2000 Pericentric inversion of the Y chromosome of infertile male. Archives of andrology 9 11111866
2007 A simplified gene-specific screen for Y chromosome deletions in infertile men. Fertility and sterility 8 17296183
2021 Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis. ChemMedChem 7 33314657
1995 Immunohistochemical detection of macrophage-derived foam cells and macrophage colony-stimulating factor in pulmonary atherogenesis of cholesterol-fed rabbits. Pathology international 7 7787988
1999 In vivo metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506) in rats and dogs: pharmacokinetics, isolation, identification, and quantification of metabolites. Drug metabolism and disposition: the biological fate of chemicals 6 9929504
2022 Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells. Stem cell reviews and reports 5 35661078
2006 Y chromosome microdeletion in a case with Klinefelter's Syndrome. Archives of andrology 5 17028090
2006 Globozoospermia: Do Y-chromosome microdeletions play a role in this rare spermatogenic disorder? The Journal of reproductive medicine 4 16967633
2015 Combination with third-generation bisphosphonate (YM529) and interferon-alpha can inhibit the progression of established bone renal cell carcinoma. Cancer science 3 26041278
2025 Structural basis for assembly and function of the Salmonella flagellar MS-ring with three different symmetries. Communications biology 2 39820129
2025 Breast cancer-derived exosomal miR-105-5p facilitates the transformation of NFs into CAFs through LATS2-NF-κB signaling. Acta biochimica et biophysica Sinica 2 40151143
2021 Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PloS one 2 34793553
2012 [Experimental research on DNA methylation profile in congenital microtia]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 2 22870707
2024 A fluorogenic substrate for the detection of lipid amidases in intact cells. Journal of lipid research 1 38369184
2023 Backbone and ILV side-chain methyl NMR resonance assignments of human Rev7/Rev3-RBM1 and Rev7/Rev3-RBM2 complexes. Biomolecular NMR assignments 1 37129702
2023 Long-Time Dynamics of Selected Molecular-Motor Components Using a Physics-Based Coarse-Grained Approach. Biomolecules 1 37371521
1997 An azoospermic male with an unbalanced autosomal-Y translocation. The Japanese journal of human genetics 1 12503194
2010 [46, XX testicular disorder of sex development: report of 2 cases and review of the literature]. Zhonghua nan ke xue = National journal of andrology 0 20626165
2002 [Study on the relationship of balanced translocation t(1;12) with spermatogenesis]. Zhonghua nan ke xue = National journal of andrology 0 12491684
1998 [Study on gene of YRRM in azoospermia]. Zhonghua yi xue za zhi 0 10923413
1998 [Analysis of a microdeletion in the AZF gene region in azoospermic patients: from research to molecular biology laboratory routine]. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 0 9616989
1998 Polymerase chain reaction analysis of the Y chromosome long arm in azoospermic patients: lack of the Y chromosome recognition motif (YRRM1) gene. International journal of urology : official journal of the Japanese Urological Association 0 9781447
1987 [Analysis of bladder cancer-associated antigens and their application to diagnosis]. Gan to kagaku ryoho. Cancer & chemotherapy 0 3606146