Affinage

KHDRBS3

KH domain-containing, RNA-binding, signal transduction-associated protein 3 · UniProt O75525

Length
346 aa
Mass
38.8 kDa
Annotated
2026-06-10
69 papers in source corpus 25 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KHDRBS3 (T-STAR/SLM2/ETOILE) is a STAR-family RNA-binding protein that functions as a sequence-specific, tissue-restricted regulator of alternative splicing and mRNA fate (PMID:10332027, PMID:23637638). It recognizes RNA through a bipartite U(U/A)AA direct-repeat motif in which both half-sites are required for high-affinity binding (PMID:19457263), and it homodimerizes through a STAR-domain interface that is structurally distinct from other STAR proteins; this dimerization raises RNA affinity and is required for splicing activity, allowing functional target selection across the transcriptome (PMID:26758068). Its best-defined role is as a potent splicing repressor of the AS4 exons of Neurexin1-3 (and additional neuronal targets such as Stxbp5l, Tomosyn2, Dgkb, Kif21a and Cask) acting through downstream UWAA-rich response elements; this is established genetically in null mice where AS4 repression collapses despite Sam68 co-expression (PMID:23637638, PMID:28009295). Functional target specificity relative to its paralog Sam68 is set largely by the density of shared binding sites flanking a target exon rather than by distinct protein-RNA contacts (PMID:27994030). Through control of Neurexin AS4 isoforms, KHDRBS3 governs neuroligin- and LRRTM2-induced GABAergic presynaptic differentiation and synapse specification, and loss of the protein reduces cortical network activity and produces anxiety and recognition-memory deficits (PMID:28009295, PMID:28939043, PMID:34196888); its own levels are set by an evolutionarily ancient homeostatic autoregulatory loop (PMID:28009295). Beyond the brain, KHDRBS3 binds and regulates the splicing or stability of mRNAs encoding cardiac sarcomere proteins (MYL2, TNNI3, TNNT2, TPM1/2, TTN), including titin I-band/PEVK splicing, and acts as a splicing regulator of VEGFA pre-mRNA in the vasculature (PMID:34273561, PMID:42253124). It directly binds YWHAZ mRNA to upregulate 14-3-3ζ and modulates CD44 variant splicing, linking it to proliferation, glycolysis and stem-like phenotypes in several cancers (PMID:37848941, PMID:29356399). KHDRBS3 activity is post-translationally controlled by BRK/Sik-mediated tyrosine phosphorylation, which inhibits its RNA binding (PMID:15471878), and by human-specific SIAH1-mediated ubiquitin-proteasomal degradation acting through an octapeptide absent in rodent orthologs (PMID:15163637). Notably, unlike its paralog SLM-1, KHDRBS3 is not phosphorylated by Src/Fyn and does not engage their SH3 adapters, distinguishing it as a non-adapter STAR protein (PMID:10077576).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1999 Medium

    Establishing KHDRBS3 as a distinct SAM68/STAR-family RNA-binding protein answered whether it is a generic Src-pathway adapter; it is not, defining it as a non-adapter RNA-binding protein with a unique nuclear localization.

    Evidence Yeast two-hybrid against RBM, GFP-fusion localization, and in vitro kinase/SH2-SH3 binding assays

    PMID:10077576 PMID:10332027

    Open questions at the time
    • Did not define an RNA target or sequence specificity
    • Functional consequence of the novel peri-nucleolar compartment unknown
  2. 2001 Medium

    Linking KHDRBS3's RNA-binding domain to growth inhibition addressed whether its biology depends on RNA contact, showing the RNA-binding domain is required for its anti-proliferative effect.

    Evidence Overexpression with RNA-binding-domain deletion mutants and colony formation assay in SV40-transformed cells

    PMID:11714634

    Open questions at the time
    • No specific RNA target identified
    • Mechanism connecting RNA binding to growth arrest not resolved
  3. 2004 High

    Identifying BRK/Sik phosphorylation and SIAH1-mediated degradation answered how KHDRBS3 activity is controlled post-translationally, establishing both an activity switch (phosphorylation inhibits RNA binding) and a human-specific stability switch on splicing output.

    Evidence In vitro kinase and RNA-binding assays; yeast two-hybrid, Co-IP, site-directed mutagenesis, proteasome-inhibitor and minigene splicing assays

    PMID:15163637 PMID:15471878

    Open questions at the time
    • Physiological stimuli that trigger BRK or SIAH1 regulation not defined
    • Whether phosphorylation and degradation act on overlapping target sets unknown
  4. 2009 High

    Defining the bipartite U(U/A)AA repeat motif answered what RNA sequence KHDRBS3 recognizes, showing both half-sites are needed for high-affinity binding.

    Evidence SELEX with in vitro binding validation and mutagenesis of motif halves

    PMID:19457263

    Open questions at the time
    • In vitro motif not yet tied to endogenous transcriptome targets
    • Did not address dimerization contribution to affinity
  5. 2013 High

    Genetic deletion in mice established KHDRBS3's principal physiological function as a brain-region-specific repressor of Neurexin1-3 AS4 splicing, demonstrating a non-redundant role despite Sam68 co-expression.

    Evidence T-STAR null mice, transcriptome-wide splicing analysis, minigene assays, cross-species (zebrafish) functional validation

    PMID:23637638

    Open questions at the time
    • Downstream synaptic and behavioral consequences not yet measured
    • Mechanism of repression at the response element not structurally defined
  6. 2016 High

    Solving the STAR-domain structure and profiling additional targets answered how KHDRBS3 achieves functional selectivity and homeostasis, revealing a unique dimerization interface required for activity and an autoregulatory feedback loop controlling its own levels.

    Evidence Crystal/NMR structure with interface mutagenesis and splicing assays; Slm2-null RNA-seq, cortical electrophysiology, behavioral assays

    PMID:26758068 PMID:28009295

    Open questions at the time
    • Molecular sensor of the autoregulatory loop not identified
    • How dimerization couples to specific exon repression mechanistically unresolved
  7. 2017 High

    Domain-swap and binding-site-density experiments answered why KHDRBS3 and Sam68 differ functionally despite similar RNA binding, showing specificity is set by site density flanking the exon and by a STAR-domain region rather than distinct RNA contacts; parallel work tied AS4 control to GABAergic presynaptic differentiation.

    Evidence Domain-swap mutagenesis, in vitro binding, minigene and in vivo splicing assays; lentiviral overexpression with neuron-fibroblast co-culture synapse rescue

    PMID:27994030 PMID:28939043

    Open questions at the time
    • How site density is read out mechanistically not defined
    • Cell-cycle role observed in cancer cells lacks molecular placement (Low-confidence)
  8. 2021 Medium

    RIP-seq in human heart extended KHDRBS3's role beyond neurons, identifying cardiac sarcomere mRNAs as targets and defining its control of titin I-band/PEVK splicing via intron retention and exon inclusion.

    Evidence RIP-seq and RNA-seq splicing analysis in cardiac tissue from DCM patients; parallel knockdown/rescue in cortical VIP interneurons

    PMID:34196888 PMID:34273561

    Open questions at the time
    • Causal contribution of titin missplicing to cardiomyopathy not established
    • Whether cardiac regulation uses the same UWAA motif unknown
  9. 2023 Medium

    Direct YWHAZ mRNA binding answered whether KHDRBS3 regulates message abundance as well as splicing, showing it upregulates 14-3-3ζ to drive proliferation and glycolysis in hepatocellular carcinoma.

    Evidence RNA pull-down and RIP, lentiviral knockdown/overexpression, rescue and xenograft assays

    PMID:37848941

    Open questions at the time
    • Mechanism of mRNA stabilization vs splicing not biochemically dissected
    • Relationship to the U(U/A)AA motif on YWHAZ not mapped
  10. 2026 Medium

    An endothelin-1-driven in vivo model placed KHDRBS3 as a VEGFA pre-mRNA splicing regulator in vasculature, connecting its activity to isoform shifts (Vegfa164/188 up, Vegfa120 down) under hypertensive stress.

    Evidence Tamoxifen-inducible ET-1 transgenic mouse, RNA-seq, RT-qPCR, immunofluorescence, and RIP-seq from DCM myocardium

    PMID:42253124

    Open questions at the time
    • Upstream pathway linking ET-1 to KHDRBS3 induction not defined
    • Functional consequence of VEGFA isoform shift for vascular phenotype not isolated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KHDRBS3's tissue-specific expression, dimerization-driven affinity, post-translational switches, and the diverse splicing-versus-stability outcomes across neurons, heart, vasculature and cancers are mechanistically unified remains unresolved.
  • No structural model of KHDRBS3 bound to an endogenous target RNA
  • Many cancer-associated circRNA/lncRNA interactions rest on single RIP/pull-down studies without reciprocal validation
  • Whether mRNA stabilization and splicing repression use distinct or shared molecular determinants is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 8 GO:0140110 transcription regulator activity 5 GO:0045182 translation regulator activity 4
Localization
GO:0005634 nucleus 2 GO:0005730 nucleolus 1
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-8953854 Metabolism of RNA 4
Partners
BRKMTDHRBMSERPINB5SIAH1

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 T-STAR/ETOILE (KHDRBS3) was identified as a novel RNA-binding protein closely related to SAM68, discovered via yeast two-hybrid screen using testis cDNA as bait for RBM (Y-chromosome RNA-binding protein). T-STAR interacts with RBM and other hnRNP G family members. When fused to GFP and transfected into HeLa cells, T-STAR accumulated in a novel nuclear compartment adjacent to the nucleolus but distinct from the peri-nucleolar compartment. Yeast two-hybrid screen, GFP fusion transfection, subcellular localization imaging Human molecular genetics Medium 10332027
1999 SLM-2 (KHDRBS3) is an RNA-binding protein that is NOT tyrosine phosphorylated by Src or p59(fyn), and does not associate with the SH3 domains of p59(fyn), Grb-2, PLCgamma-1, or p120(rasGAP), unlike its paralog SLM-1. This distinguishes SLM-2 from SLM-1 and SAM68 as a non-adapter protein for these signaling partners. In vitro kinase assay, SH2/SH3 domain binding assays Proceedings of the National Academy of Sciences of the United States of America Medium 10077576
2001 Overexpression of T-STAR (KHDRBS3) in SV40-transformed immortalized cells resulted in strong reduction of colony formation; deletion of the RNA-binding domain abrogated this growth-inhibitory effect, indicating the RNA-binding domain is required for T-STAR's growth-inhibitory function. Overexpression with deletion mutants, colony formation assay Cell growth & differentiation Medium 11714634
2004 The tyrosine kinase BRK/Sik phosphorylates SLM-2 (KHDRBS3), and this phosphorylation inhibits the RNA-binding ability of SLM-2. Expression of active BRK/Sik resulted in increased SLM-2 phosphorylation and increased nuclear retention of BRK/Sik. In vitro kinase assay, RNA-binding assay, phosphorylation analysis The Journal of biological chemistry High 15471878
2004 SIAH1 (E3 ubiquitin ligase) binds to an octapeptide sequence in human T-STAR (KHDRBS3) and targets it for proteasome-dependent degradation. Rodent T-STAR orthologues lack this SIAH1-binding site and are not degraded; a double amino acid substitution in mouse T-STAR that mimics the human SIAH1-binding site brings mouse T-STAR under SIAH1 control. Human T-STAR-dependent alternative splicing is modulated by SIAH1, demonstrating that proteasomal degradation controls T-STAR splicing activity. Yeast two-hybrid screen, co-immunoprecipitation, proteasome inhibitor assays, minigene splicing assays, site-directed mutagenesis Human molecular genetics High 15163637
2009 SLM-2 (KHDRBS3) binds RNA via a bipartite U(U/A)AA direct repeat motif identified by SELEX. Both halves of the bipartite motif are required for high-affinity RNA binding by SLM-2. SELEX (Systematic Evolution of Ligands by EXponential enrichment), in vitro RNA binding assays BMC molecular biology High 19457263
2009 Mouse T-STAR (KHDRBS3) directly binds Fabp9 mRNA, with binding sites located in a short sequence of the coding region and 3' UTR of Fabp9 mRNA, as identified from testis extract by SNAAP (isolation of specific nucleic acids associated with proteins). SNAAP method (protein-RNA co-isolation from testis extract), direct RNA binding assay Biochemistry. Biokhimiia Low 19916944
2011 SerpinB5 physically interacts with KHDRBS3 in gastric cancer cells, confirmed by co-immunoprecipitation. KHDRBS3 interacts with FBXO32 mRNA, as shown by RNA co-immunoprecipitation. KHDRBS3 protein is primarily detected in the nucleus of normal mucosal cells. Yeast two-hybrid screening, co-immunoprecipitation, RNA co-immunoprecipitation, Western blotting, immunohistochemistry Oncology reports Medium 21725612
2013 T-STAR (KHDRBS3) acts as a potent splicing repressor of the alternatively spliced segment 4 (AS4) exons from each of the Neurexin1-3 genes, and exon 23 of Stxbp5l, in the mouse brain. T-STAR expression is highest in forebrain structures (hippocampus), which correlates with maximal Neurexin1-3 AS4 splicing repression. In T-STAR null mice, AS4 splicing repression dramatically decreased despite co-expression of Sam68. T-STAR controls Neurexin2 AS4 splicing through a UWAA-rich response element immediately downstream of the regulated exon. Human T-STAR represses zebrafish Nrxn3 AS4 splicing, indicating an ancient mechanism. T-STAR null mouse generation, transcriptome-wide splicing analysis, minigene transfection assays, cross-species functional assays PLoS genetics High 23637638
2016 Crystal/NMR structure of T-STAR (KHDRBS3) STAR domain revealed an unexpected dimerization mode different from other STAR family members. This unique dimerization interface is required for biological activity in splicing regulation, and increased RNA affinity through dimer formation enables functional target selection within the transcriptome. Crystal structure determination, NMR, mutagenesis of dimerization interface, splicing assays Nature communications High 26758068
2016 SLM2 (KHDRBS3) controls the splicing of Tomosyn2, LysoPLD/ATX, Dgkb, Kif21a, and Cask in addition to Neurexin1-3 AS4. SLM2 levels are maintained by a homeostatic feedback control pathway (autoregulation) that predates the divergence of SLM2 and Sam68. Loss of SLM2 in null mice decreases cortical neural network activity dependent on synaptic connections between SLM2-expressing pyramidal neurons and interneurons; these mice are also anxious and show decreased novel object recognition. Slm2-null mice, RNA-seq splicing analysis, cortical network electrophysiology, behavioral assays Cell reports High 28009295
2017 SLM2 (KHDRBS3) and Sam68 show paralog-specific activity on Neurexin2 AS4 splicing despite similar RNA binding. A protein domain-swap experiment identified a region including the STAR domain (not the RNA-contact residues) that differentiates SLM2 and Sam68 activity. The density of shared RNA binding sites flanking a target exon — rather than different paralog-specific protein-RNA contacts — controls functional target specificity: doubling the number of binding sites around Neurexin2 AS4 switched it to joint control by both paralogs. Domain-swap mutagenesis, in vitro RNA binding, in vivo splicing assays, minigene reporter assays Nucleic acids research High 27994030
2017 Knockdown of KHDRBS3 in human ovarian cancer CAOV-3 cells caused G0/G1 phase cell cycle arrest and inhibited cell proliferation, indicating KHDRBS3 is required for cell cycle progression in these cells. siRNA knockdown, MTT proliferation assay, flow cytometry cell cycle analysis Xi bao yu fen zi mian yi xue za zhi Low 28871947
2017 SLM2 (KHDRBS3) expression in cerebellar neurons controls AS4 splicing of Nrxn genes; ectopic SLM2 expression caused marked skipping of exon 20 of Nrxn AS4. SLM2-dependent AS4 splicing of Nrxn3 is required for neuroligin-induced GABAergic presynaptic differentiation: lentiviral Nrxn3 containing exon 20 rescued reduced GABAergic contacts in SLM2-overexpressing co-cultures. Lentiviral overexpression, neuron-fibroblast co-culture synapse formation assay, splicing analysis Biochemical and biophysical research communications Medium 28939043
2018 SALL4 transcription factor upregulates KHDRBS3 expression, and KHDRBS3 in turn modulates CD44 alternative splicing to produce a CD44 variant (CD44v) lacking exons 8 and 9. This CD44v isoform positively contributes to cancer stemness and anoikis resistance in basal-like breast cancer cells. CD44v overexpression rescued the reduction in sphere formation caused by KHDRBS3 knockdown. shRNA knockdown, overexpression, sphere formation assay, RT-PCR splicing analysis, anoikis assay Cancer medicine Medium 29356399
2019 Metadherin interacts with T-STAR (KHDRBS3) as shown by yeast two-hybrid assay and immunoprecipitation. Metadherin influences splice site selection in CD44v5-luc minigene reporter assays in a dose-dependent manner. Yeast two-hybrid, immunoprecipitation, minigene splicing reporter assay Cancers Medium 31450747
2019 KHDRBS3 binds to circular RNA DENND4C (cDENND4C) and increases its stability in glioma endothelial cells. This KHDRBS3-cDENND4C interaction regulates blood-tumor barrier (BTB) permeability via a cDENND4C/miR-577 axis that controls tight junction proteins ZO-1, occludin, and claudin-1. RNA immunoprecipitation, knockdown, overexpression, permeability assays, Western blotting for tight junction proteins Cell death & disease Low 31296839
2020 KHDRBS3 regulates CD44 variant expression in gastric cancer cells, contributing to acquisition of cancer stem cell-like features including multi-drug resistance and organoid formation in 5-FU-resistant gastric cancer organoids. Organoid culture, microarray analysis, RT-PCR, Western blotting, drug resistance assays Oncogene Low 33046798
2021 SLM2/KHDRBS3 binds mRNAs of sarcomere constituents MYL2, TNNI3, TNNT2, TPM1/2, and TTN in the human heart (identified by RNA-immunoprecipitation sequencing). SLM2 mediates intron retention, prevents exon exclusion, and thereby controls alternative splicing of the PEVK domain-encoding region and another part of the I-band region of titin mRNA. RNA-immunoprecipitation sequencing (RIP-seq), RNA-seq splicing analysis, cardiac tissue from DCM patients Genomics, proteomics & bioinformatics Medium 34273561
2021 SLM2 (KHDRBS3) expression in cortical VIP-positive GABAergic interneurons (originating from caudal ganglionic eminence) contributes to GABAergic synapse specification. SLM2 knockdown reduced NRX AS4(-) isoform expression and weakened LRRTM2-induced synapse formation; addition of NRX AS4(-) rescued synaptic formation in SLM2 knockdown neurons. In vitro knockdown, artificial synapse formation assay, splicing analysis, immunostaining for interneuron subtypes Neurochemical research Medium 34196888
2022 KHDRBS3 interacts with lncRNA MIR17HG (RNA immunoprecipitation). KHDRBS3 knockdown reduced paclitaxel resistance and glycolysis in ovarian cancer cells; overexpression of KHDRBS3 enhanced these phenotypes, which were rescued by MIR17HG overexpression. MIR17HG targets CLDN6 3'UTR to negatively regulate CLDN6 expression, defining a KHDRBS3-MIR17HG-CLDN6 regulatory axis. RNA immunoprecipitation, MTT assay, colony formation, apoptosis assay, Seahorse glycolysis assay, xenograft model Life sciences Low 35051418
2023 KHDRBS3 directly binds YWHAZ mRNA (encoding 14-3-3ζ), as demonstrated by RNA pull-down and RNA immunoprecipitation assays. KHDRBS3 upregulates 14-3-3ζ protein expression, and 14-3-3ζ silencing reversed the promotion of proliferation and glycolysis caused by KHDRBS3 overexpression in hepatocellular carcinoma cells. RNA pull-down, RNA immunoprecipitation, lentiviral knockdown/overexpression, xenograft model, functional proliferation and glycolysis assays Cancer cell international Medium 37848941
2023 circHECTD1 interacts with KHDRBS3 (demonstrated by RNA pull-down and RIP), and this interaction enhanced stability of EZH2 mRNA, increasing EZH2 protein levels and promoting proliferation and migration of vascular smooth muscle cells. RNA pull-down, RNA immunoprecipitation, knockdown/overexpression, CCK8, transwell assays Journal of inflammation research Low 36998321
2025 In hepatocellular carcinoma, the circFOXP1-encoded protein p196 directly binds KHDRBS3 through its D2 domain, forming a complex that stabilizes ULK1 mRNA, thereby increasing ULK1 protein levels, activating autophagy and accelerating tumor progression. RNA immunoprecipitation, co-immunoprecipitation, RNA pull-down, in vitro binding assays, loss- and gain-of-function assays International journal of nanomedicine Low 40292405
2026 In a mouse model of endothelin-1 overexpression, Khdrbs3 was the top upregulated gene in mesenteric arteries. KHDRBS3 protein was increased in aortic endothelial cells and vascular smooth muscle cells. KHDRBS3 acted as a splicing regulator of VEGFA pre-mRNA, with ET-1 overexpression upregulating Vegfa164 (exon 7 retention) and Vegfa188 (exons 6 and 7 retention) isoforms and downregulating Vegfa120. RNA-immunoprecipitation sequencing from DCM myocardium identified VEGFA and four VSMC-specific pre-mRNAs as KHDRBS3 targets. RNA-sequencing, RT-qPCR, immunofluorescence microscopy, RNA-immunoprecipitation sequencing (RIP-seq), tamoxifen-inducible transgenic mouse model Journal of hypertension Medium 42253124

Source papers

Stage 0 corpus · 69 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Molecular and cellular biology 117 16847337
2012 Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. Proceedings of the National Academy of Sciences of the United States of America 116 22307609
2005 The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Molecular biology of the cell 112 15689497
1999 T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Human molecular genetics 97 10332027
2006 Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Molecular and cellular biology 90 16738335
1999 Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. Proceedings of the National Academy of Sciences of the United States of America 90 10077576
2009 Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma. PloS one 79 19584924
2013 The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain. PLoS genetics 72 23637638
2004 The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. The Journal of biological chemistry 72 15471878
2006 The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress. Molecular and cellular biology 67 17101780
2009 The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs. BMC molecular biology 66 19457263
2016 Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68. Nature communications 60 26758068
2021 Isolation and Characterization of a Novel Salmonella Phage vB_SalP_TR2. Frontiers in microbiology 56 34234757
2020 Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell. Oncogene 52 33046798
2004 SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. Human molecular genetics 44 15163637
2019 The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing. Cancers 40 31450747
2018 SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer. Cancer medicine 40 29356399
2019 KHDRBS3 regulates the permeability of blood-tumor barrier via cDENND4C/miR-577 axis. Cell death & disease 36 31296839
2011 ETOILE regulates developmental patterning in the filamentous brown alga Ectocarpus siliculosus. The Plant cell 35 21478443
2012 Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae. Cell cycle (Georgetown, Tex.) 31 22895050
2022 KHDRBS3 promotes paclitaxel resistance and induces glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial ovarian cancer. Life sciences 30 35051418
2022 Isolation and identification of the broad-spectrum high-efficiency phage vB_SalP_LDW16 and its therapeutic application in chickens. BMC veterinary research 26 36329508
2016 A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior. Cell reports 22 28009295
2018 SALP, a new single-stranded DNA library preparation method especially useful for the high-throughput characterization of chromatin openness states. BMC genomics 21 29439663
2011 SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric cancer cells. Oncology reports 21 21725612
2005 Expression of the floral B-function gene SLM2 in female flowers of Silene latifolia infected with the smut fungus Microbotryum violaceum. Plant & cell physiology 21 15755743
2021 KHDRBS3 promotes multi-drug resistance and anchorage-independent growth in colorectal cancer. Cancer science 19 33423358
2020 Finding new cancer epigenetic and genetic biomarkers from cell-free DNA by combining SALP-seq and machine learning. Computational and structural biotechnology journal 19 32774784
2017 Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control. Nucleic acids research 16 27994030
2016 Rapid Evolutionary Rates and Unique Genomic Signatures Discovered in the First Reference Genome for the Southern Ocean Salp, Salpa thompsoni (Urochordata, Thaliacea). Genome biology and evolution 16 27624472
2021 SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Genomics, proteomics & bioinformatics 15 34273561
2010 Higher HIV-1 DNA associated with lower gains in CD4 cell count among patients with advanced therapeutic failure receiving optimized treatment (ANRS 123--ETOILE). The Journal of antimicrobial chemotherapy 15 20667886
2019 Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins. The FEBS journal 12 30843356
2019 Decoding genetic and epigenetic information embedded in cell free DNA with adapted SALP-seq. International journal of cancer 11 30746694
2006 Expression of T-STAR gene is associated with regulation of telomerase activity in human colon cancer cell line HCT-116. World journal of gastroenterology 11 16810759
2001 Down-regulation of T-STAR, a growth inhibitory protein, after SV40-mediated immortalization. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 11 11714634
2023 KHDRBS3 accelerates glycolysis and promotes malignancy of hepatocellular carcinoma via upregulating 14-3-3ζ. Cancer cell international 9 37848941
2025 BIMSSA: enhancing cancer prediction with salp swarm optimization and ensemble machine learning approaches. Frontiers in genetics 8 39834551
2010 Expression and functions of the star proteins Sam68 and T-STAR in mammalian spermatogenesis. Advances in experimental medicine and biology 8 21189686
2025 Exosome-Delivered circFOXP1 Upregulates Autophagy and Promotes Hepatocellular Carcinoma Progression Through Its Encoded p196 Protein Targeting the KHDRBS3/ULK1 Axis. International journal of nanomedicine 7 40292405
2001 T-STAR gene: fine mapping in the candidate region for childhood absence epilepsy on 8q24 and mutational analysis in patients. Epilepsy research 7 11463515
2011 Space-time decoupling in the branching process in the mutant étoile of the filamentous brown alga Ectocarpus siliculosus. Plant signaling & behavior 6 22095146
2000 Intravenous administration of stabilized antisense lipid particles (SALP) leads to activation and expansion of liver natural killer cells. Antisense & nucleic acid drug development 6 10905558
2021 Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes. Neurochemical research 5 34196888
2023 circHECTD1 Promotes the Proliferation and Migration of Human Brain Vascular Smooth Muscle Cells via Interacting with KHDRBS3 to Stabilize EZH2 mRNA Expression. Journal of inflammation research 4 36998321
2017 [Knock-down of KHDRBS3 gene inhibits proliferation of human ovarian cancer CAOV-3 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 4 28871947
2017 Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures. Biochemical and biophysical research communications 4 28939043
2009 Identification of messenger RNA substrates for mouse T-STAR. Biochemistry. Biokhimiia 4 19916944
2024 KHDRBS3 facilitates self-renewal and temozolomide resistance of glioblastoma cell lines. Life sciences 3 39413902
2025 Memetic Salp Swarm Algorithm for economic load dispatch problems. Scientific reports 2 40835728
2024 Characterization and genomic analysis of Salmonella Abortusequi phage, vB_SalP_LDDK01, and its biocontrol application in donkey meat. Frontiers in cellular and infection microbiology 2 39764155
2018 Immunological response to bacterial infection in a pelagic tunicate: Inflammation in the salp Thalia democratica. Journal of invertebrate pathology 2 30359568
2003 [Association of child absence epilepsy with T-STAR gene]. Zhonghua yi xue za zhi 2 12921630
2026 Comparative embryogenesis of two salp species reveals rogue development and evolutionary divergence from sessile tunicates. PLoS biology 1 41843499
2025 Integrated transcriptome analysis and in silico investigations identify KHDRBS3 to target with steroidal lactone in paclitaxel resistance breast cancer. Biochemical and biophysical research communications 1 40651363
2020 Safety biomarkers for development of vaccines and biologics: Report from the safety biomarkers symposium held on November 28-29, 2017, Marcy l'Etoile, France. Vaccine 1 33187767
2018 Correction to: SALP, a new single-stranded DNA library preparation method especially useful for the high-throughput characterization of chromatin openness states. BMC genomics 1 29728049
2026 Macroid Formation in Salmacina stellaebayensis n. sp. From Mauritania's Baie de l'Étoile With New Insights on Mitogenome Evolution in Serpulidae (Annelida). Ecology and evolution 0 41624108
2026 Optimized Gene Selection Using Nomadic People and Salp Swarm Algorithms for Cancer Detection. IEEE transactions on computational biology and bioinformatics 0 42024922
2026 Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expression. Journal of hypertension 0 42253124
2025 KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion. In vitro cellular & developmental biology. Animal 0 40760232
2025 An Enhanced Knowledge Salp Swarm Algorithm for Solving the Numerical Optimization and Seed Classification Tasks. Biomimetics (Basel, Switzerland) 0 41002872
2025 Salp swarm-optimized machine learning models for predicting preoperative aortic rupture risk in acute type a aortic dissection patients. Frontiers in physiology 0 41245264
2025 Classification of coding and non-coding regions in eukaryotic gene sequences using an adaptive anti-notch filter designed using hybrid Salp SwarmWhale algorithm incorporating a modified error function. Computational biology and chemistry 0 41259968
2025 Roles of KHDRBS2 and KHDRBS3 in prostate cancer progression and AR-V7 regulation. Discover oncology 0 41417173
2025 Therapeutic efficacy of phage vB_SalP_NW15 and cinnamaldehyde against drug-resistant Salmonella Enteritidis in a chicken infection model. Poultry science 0 41485350
2024 Salp-J Colony Optimization-based advanced hybrid ensemble deep predictor with LSTM for protein structure prediction. Journal of biomolecular structure & dynamics 0 38444340
2022 An internet traffic classification method based on echo state network and improved salp swarm algorithm. PeerJ. Computer science 0 35494824
2022 Application of an improved Discrete Salp Swarm Algorithm to the wireless rechargeable sensor network problem. Frontiers in bioengineering and biotechnology 0 36204468

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