Affinage

RAB26

Ras-related protein Rab-26 · UniProt Q9ULW5

Length
256 aa
Mass
27.9 kDa
Annotated
2026-06-10
33 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB26 is a GTP-binding small GTPase that coordinates membrane trafficking and selective autophagy of secretory and synaptic vesicles, lysosomes, and surface receptors (PMID:25643395, PMID:37289842). In its active GTP-bound state it engages ATG16L1 as a direct effector, routing synaptic and secretory vesicles into preautophagosomal structures marked by LC3B and Rab33B for autophagic degradation (PMID:25643395); this RAB26–ATG16L1 axis targets active phosphorylated SRC for degradation, thereby maintaining endothelial adherens junctions and limiting vascular permeability, and suppressing tumor cell migration (PMID:29965781, PMID:33731709). RAB26 localizes to secretory granule membranes and to LAMP1/cathepsin D-positive lysosomes, driving lysosome coalescence and influencing organelle positioning (PMID:10857477, PMID:24413166), and it controls regulated secretion: it restrains cAMP-dependent granule exocytosis (PMID:16076461) and directly binds the synaptotagmin-1 C2A domain to disrupt the Syt1–SNAP25 interaction and limit insulin granule exocytosis (PMID:37289842). RAB26 separately governs anterograde Golgi-to-surface transport of multiple receptors through activation-dependent binding—of α2-adrenergic receptors, EPOR, and AT1R—shaping adrenergic signaling, macrophage polarization, and hypoxic vascular remodeling (PMID:23105096, PMID:34925338, PMID:41231254). It also protects mitochondrial integrity by binding VDAC1 to block its oligomerization and by regulating MFN2 delivery, thereby restraining cGAS-STING activation and ferroptosis (PMID:42176907, PMID:37060270). RAB26 transcription is activated by MIST1 in secretory zymogenic cells, where it is required for large secretory granule formation (PMID:20038531), and by SMAD3 and KLF4 in cancer contexts (PMID:35291909, PMID:37431852), while ROS/cigarette-smoke-driven DNMT3b promoter hypermethylation suppresses its expression (PMID:36610560).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2000 Medium

    Establishing that Rab26 is a bona fide GTP-binding protein resident on secretory granule membranes placed it in the regulated secretion machinery rather than a generic cytosolic GTPase.

    Evidence GTP-binding assay, subcellular fractionation, and immuno-EM in parotid acinar cells

    PMID:10857477

    Open questions at the time
    • Effectors and GEF/GAP regulators not identified
    • Functional consequence of granule localization not yet tested
  2. 2005 Medium

    Antibody-inhibition in permeabilized acinar cells showed Rab26 selectively supports cAMP-dependent, not Ca2+-dependent, granule exocytosis, assigning it to a specific secretory recruitment step.

    Evidence Antibody inhibition of amylase release in streptolysin-O-permeabilized parotid acinar cells with agonist-specificity

    PMID:16076461

    Open questions at the time
    • Molecular partners mediating cAMP-selective recruitment unknown
    • Single lab, single tissue
  3. 2009 High

    Identifying RAB26 as a direct MIST1 transcriptional target and a requirement for secretory granule biogenesis connected its expression program to secretory cell differentiation.

    Evidence ChIP/EMSA of MIST1 at promoter E-boxes plus dominant-negative and prenylation-inhibitor granule-formation assays in zymogenic cells

    PMID:20038531

    Open questions at the time
    • How RAB26 mechanistically builds large granules not resolved
    • Effector for granule formation not identified
  4. 2012 High

    Demonstrating activation-dependent binding to the α2B-AR third intracellular loop and Golgi arrest upon RAB26 loss revealed a distinct role in anterograde receptor trafficking beyond secretion.

    Evidence Mutant overexpression, siRNA, surface receptor quantification, and GTP-dependent pulldown in cell lines

    PMID:23105096

    Open questions at the time
    • Whether trafficking and autophagy functions use distinct effectors unclear
    • Generality across other GPCRs not established at this stage
  5. 2014 Medium

    Showing RAB26 associates with lysosomes and drives their perinuclear coalescence and mitochondrial repositioning expanded its remit to organelle clustering and positioning.

    Evidence Fluorescence co-localization with lysosomal/granule markers and transfection in differentiating zymogenic cells

    PMID:24413166

    Open questions at the time
    • Motor/tethering machinery for clustering not identified
    • Causal basis of mitochondrial redistribution unknown
  6. 2015 High

    Identifying ATG16L1 as a GTP-dependent direct effector that routes vesicles into preautophagosomal structures defined the core molecular mechanism of RAB26-mediated selective autophagy.

    Evidence Active vs GDP-preferring mutant overexpression in neurons, autophagy-marker co-localization, and direct effector binding assay

    PMID:25643395

    Open questions at the time
    • Cargo selectivity determinants not fully defined
    • GEF activating RAB26 for this step unknown
  7. 2018 High

    Linking the RAB26–ATG16L1 axis to autophagic degradation of phospho-SRC and adherens-junction stability gave the autophagy function a defined substrate and an in vivo vascular phenotype.

    Evidence RAB26 KO mice permeability assays, reciprocal Co-IP with ATG16L1, and phospho-SRC/phospho-CDH5 westerns in endothelial cells

    PMID:29965781

    Open questions at the time
    • How active SRC is selected as autophagic cargo unresolved
    • Direct vs indirect SRC engagement not distinguished
  8. 2019 Medium

    Placing RAB26 downstream of SNRPB splicing regulation and as a tumorigenicity modifier introduced post-transcriptional control of RAB26 levels in cancer.

    Evidence SNRPB siRNA, RT-PCR of intron-7 retention/NMD, and RAB26 re-expression rescue in NSCLC

    PMID:31511502

    Open questions at the time
    • RAB26 effector mediating tumorigenicity not identified
    • Single lab
  9. 2020 Medium

    Showing the Coxiella effector CvpF hijacks RAB26 to recruit LC3B to bacterial vacuoles demonstrated that pathogens subvert RAB26-dependent autophagy for virulence.

    Evidence Transposon screen, CvpF–RAB26 pulldown, LC3B recruitment assay, and SCID mouse virulence model

    PMID:32116095

    Open questions at the time
    • Whether CvpF acts as a GEF/GAP mimic or effector competitor unknown
    • Structural basis of CvpF–RAB26 binding undefined
  10. 2021 Medium

    Extending the SRC-autophagy mechanism to breast cancer migration, and defining EPOR surface trafficking for macrophage polarization, generalized RAB26's roles across autophagy and receptor delivery.

    Evidence Co-IP with ATG16L1 and migration assays in breast cancer cells; RAB26 KO mice and surface EPOR/M1-M2 polarization assays in macrophages

    PMID:33731709 PMID:34925338

    Open questions at the time
    • Whether EPOR trafficking uses the same effector machinery as GPCRs unclear
    • Direct RAB26–EPOR interaction not demonstrated here
  11. 2022 Medium

    Multiple 2022 studies anchored RAB26 in transcriptional networks (SMAD3, KLF4), redox-driven epigenetic silencing (DNMT3b), conserved granule-maturation control in Drosophila, and α-synuclein-sensitive synaptic autophagy.

    Evidence ChIP/luciferase for SMAD3 and KLF4; promoter methylation and MAPK readouts for ROS/DNMT3b; Drosophila Rab26/Mon1 epistasis; α-synuclein shRNA rescue of Rab26-ATG16L1 co-localization in neurons

    PMID:35291909 PMID:36341850 PMID:36600084 PMID:36610560 PMID:37431852

    Open questions at the time
    • How divergent transcriptional inputs are integrated unknown
    • Mechanism by which α-synuclein disrupts the RAB26-ATG16L1 interface undefined
  12. 2023 High

    Direct binding to synaptotagmin-1 C2A and to mitochondrial MFN2 broadened RAB26 from a trafficking GTPase to a regulator of exocytic priming and mitochondrial function.

    Evidence GST pulldown with Syt1 C2A, KO mice and TIRF insulin-granule imaging; Co-IP with MFN2, KO macrophages and mitochondrial ROS/ATP/phagocytosis assays

    PMID:37060270 PMID:37289842

    Open questions at the time
    • Whether Syt1 sequestration is GTP-dependent not fully resolved
    • How MFN2 transport is mechanistically coupled to RAB26 unknown
  13. 2025 Medium

    Defining RAB26 control of AT1R surface transport in hypoxic vascular remodeling and SERT autophagic degradation in neurons connected RAB26 to disease-relevant receptor homeostasis and behavior.

    Evidence Co-IP and KO mice in PAH model (AT1R/STAT3/YAP1); KO mice with behavioral, electrophysiological and EM analyses plus Co-IP with SERT

    PMID:40687824 PMID:41231254

    Open questions at the time
    • Whether AT1R and SERT use the same trafficking machinery unclear
    • Direct effector bridging RAB26 to these receptors not defined
  14. 2026 Medium

    Identifying RAB26 binding to VDAC1 to block oligomerization and stabilization of EPOR against BTRC-mediated degradation tied RAB26 to suppression of ferroptosis and cGAS-STING signaling.

    Evidence Co-IP and cross-linking with VDAC1, TEM, KO mice and STING inhibition; Co-IP of BTRC-EPOR, KO macrophages and ferroptosis/mitophagy assays in sepsis models

    PMID:42086108 PMID:42176907

    Open questions at the time
    • Whether VDAC1 and EPOR functions are mechanistically related unknown
    • Single lab for each axis

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single GTPase coordinates the choice among selective autophagy, anterograde receptor delivery, secretory granule control, and mitochondrial protection—and which GEFs, GAPs, and effectors switch between these programs—remains unresolved.
  • No structural model of RAB26 with ATG16L1 or receptor partners
  • Upstream GEF/GAP regulators largely unidentified
  • Determinants selecting distinct cargo/effectors across tissues unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0140313 molecular sequestering activity 1
Localization
GO:0031410 cytoplasmic vesicle 3 GO:0005739 mitochondrion 2 GO:0005764 lysosome 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-9609507 Protein localization 3 R-HSA-9612973 Autophagy 3
Partners
ADRA2BAGTR1ATG16L1EPORMFN2SLC6A4SYT1VDAC1

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2015 Rab26 (GTP-bound/active form) specifically associates with clusters of synaptic vesicles in neurites and directs synaptic and secretory vesicles into preautophagosomal structures co-localizing with Atg16L1, LC3B, and Rab33B. Atg16L1 was identified as a direct effector of Rab26, binding selectively to the GTP-bound form of Rab26. Overexpression of active vs. GDP-preferring Rab26 mutants in neurons, co-localization with autophagy markers, direct binding assay (Atg16L1 as effector) eLife High 25643395
2009 RAB26 is a direct transcriptional target of the transcription factor MIST1, which binds conserved CATATG E-boxes in the RAB26 promoter to activate its transcription. RAB26 activity (alongside RAB3D) is required for the formation of large secretory granules in gastric zymogenic cells; dominant-negative RAB26 and RAB prenylation inhibitors abrogate granule formation. ChIP/EMSA showing MIST1 binding to RAB26 E-boxes; dominant-negative RAB26 transfection; RAB prenylation inhibitor treatment; RFP-pepsinogen C granule formation assay Molecular and cellular biology High 20038531
2000 Rab26 protein localizes specifically to secretory granule membranes in parotid acinar cells, binds GTP, and its immunostaining disappears after isoproterenol treatment, consistent with a role in regulated secretory granule exocytosis. Western blotting with GTP-binding assay ([α-32P]GTP), subcellular fractionation, immunocytochemistry (light and electron microscopy) Histochemistry and cell biology Medium 10857477
2005 Rab26 localizes to mature (not immature) secretory granule membranes in parotid acinar cells. Anti-Rab26 antibody inhibits isoproterenol (β-adrenergic/cAMP)-induced amylase release from permeabilized acinar cells but has no effect on Ca2+-induced amylase release, indicating a selective role in cAMP-dependent granule recruitment to the plasma membrane. Percoll-sucrose density gradient fractionation; antibody inhibition of exocytosis in streptolysin-O-permeabilized acinar cells; amylase secretion assay Archives of oral biology Medium 16076461
2012 Rab26 regulates anterograde transport of α2A- and α2B-adrenergic receptors from the Golgi to the cell surface. Rab26 mutants and siRNA-mediated knockdown arrest receptors in the Golgi and reduce cell surface receptor numbers. Rab26 directly and activation-dependently interacts with the third intracellular loop of α2B-AR. Rab26 mutant overexpression and siRNA knockdown; cell surface receptor quantification; co-immunoprecipitation/pulldown demonstrating direct GTP-dependent interaction with α2B-AR third intracellular loop The Journal of biological chemistry High 23105096
2014 RAB26 associates predominantly with LAMP1/cathepsin D-positive lysosomes (not secretory granules) and drives lysosome coalescence into a central perinuclear region. Lysosome clustering caused by increased RAB26 expression in turn redistributes mitochondria into distinct subcellular neighborhoods. Fluorescence co-localization with lysosomal and secretory granule markers; induction of zymogen-secreting cell differentiation; direct transfection of RAB26 Journal of cell science Medium 24413166
2018 RAB26 promotes autophagic degradation of phosphorylated (active) SRC kinase in endothelial cells through direct, GTP-dependent interaction with ATG16L1. Loss of RAB26 leads to SRC phosphorylation, CDH5/VE-cadherin phosphorylation, CDH5 internalization, and disruption of adherens junctions, increasing vascular permeability in acute lung injury. RAB26 knockout mice (vascular permeability assays), siRNA depletion and overexpression in HPMECs, co-immunoprecipitation of RAB26 with ATG16L1 (GTP-dependent), western blot for phospho-SRC and phospho-CDH5 Autophagy High 29965781
2019 RAB26 is a critical target of SNRPB-mediated splicing regulation in NSCLC; SNRPB depletion causes intron 7 retention in RAB26 mRNA, triggering nonsense-mediated decay (NMD) and reducing RAB26 protein levels. Forced RAB26 re-expression partially rescues decreased tumorigenicity caused by SNRPB depletion. siRNA knockdown of SNRPB; RT-PCR demonstrating intron retention; NMD pathway analysis; RAB26 re-expression rescue assay Cell death & disease Medium 31511502
2020 The Coxiella burnetii effector protein CvpF specifically interacts with host RAB26, recruiting the autophagosomal marker LC3B to Coxiella-containing vacuoles, thereby subverting RAB26-dependent autophagy to promote vacuole biogenesis and bacterial virulence. Transposon mutant library screen; co-immunoprecipitation/pulldown of CvpF with RAB26; LC3B recruitment assay; SCID mouse virulence model Autophagy Medium 32116095
2021 Rab26 mediates autophagic degradation of phosphorylated Src kinase in breast cancer cells through interaction with ATG16L1. Rab26 promotes endosomal translocation of Src and reduces Src at focal adhesions, thereby suppressing cell migration and invasion. Rab26 overexpression and knockdown; immunofluorescence co-localization of Src with endosomal markers; Co-IP with ATG16L1; migration/invasion assays Cell death & disease Medium 33731709
2021 Rab26 regulates cell surface transport of the erythropoietin receptor (EPOR) in macrophages; loss of Rab26 reduces surface EPOR levels, impairs EPO-mediated M2 macrophage polarization, and tips macrophage phenotype toward M1. Rab26 KO mice; macrophage polarization assays; cell surface EPOR measurement after Rab26 modulation Frontiers in immunology Medium 34925338
2022 SMAD3 transcriptionally activates RAB26 by binding to the RAB26 promoter, as demonstrated by dual-luciferase reporter and chromatin immunoprecipitation assays. SMAD3 overexpression blocks inhibitory effects of RAB26 silencing on NSCLC cell proliferation, migration, and invasion. Dual-luciferase reporter assay; chromatin immunoprecipitation (ChIP); RAB26 shRNA knockdown; SMAD3 overexpression rescue Bioengineered Medium 35291909
2022 In Drosophila salivary glands, Rab26 localizes to immature secretory glue granules and prevents their acidification and premature maturation. Rab26 loss accelerates granule maturation, acidification, fusion, and lysosomal breakdown (crinophagy). Loss of Mon1 (an activator of Rab7) causes Rab26 to remain on large granules, implicating a Mon1-Rab7 pathway that counteracts Rab26 to drive granule maturation. Rab26 mutant Drosophila; fluorescence microscopy of glue granule acidification and fusion; genetic epistasis with Mon1 mutant; overexpression studies Cellular and molecular life sciences Medium 36600084
2022 Manganese-induced α-synuclein overexpression suppresses Rab26-ATG16L1 co-localization and reduces LC3II-positive synaptic vesicles, impairing Rab26-dependent autophagy initiation and causing accumulation of dysfunctional synaptic vesicles. Knockdown of α-synuclein with shRNA restores Rab26-ATG16L1 co-localization in Mn-exposed neurons. α-synuclein shRNA knockdown in primary hippocampal neurons; co-localization of Rab26 with ATG16L1 and LC3II-positive SVs by immunofluorescence; in vivo Mn exposure mouse model The Science of the total environment Medium 36341850
2023 Rab26 directly interacts with synaptotagmin-1 (Syt1) via the Syt1 C2A domain (shown by GST pulldown), interfering with Syt1-SNAP25 interaction and inhibiting exocytosis of newcomer insulin granules. Rab26 knockout mice show increased glucose-stimulated insulin secretion, and Rab26 overexpression in islets suppresses insulin secretion; Rab26 overexpression causes clustering of insulin granules. Rab26-/- mice (CRISPR/Cas9); GST pulldown of Rab26 with Syt1 C2A domain; TIRF microscopy of insulin granule exocytosis; Rab26 KD in insulinoma cells; islet transplantation assay PLoS biology High 37289842
2023 Rab26 interacts with mitochondrial fusion protein MFN2 and regulates MFN2 transport to mitochondria. Rab26 deficiency reduces mitochondrial MFN2 levels, decreases mitochondrial ROS and ATP production, and impairs macrophage phagocytosis and bacterial clearance. Co-immunoprecipitation of Rab26 with MFN2; Rab26 KO bone marrow-derived macrophages; MFN2 siRNA knockdown; mitochondrial ROS and ATP measurement; phagocytosis/bacterial killing assays; in vivo ARDS mouse model The FEBS journal Medium 37060270
2023 KLF4 transcriptionally targets RAB26 (verified by luciferase reporter assay) to inhibit autophagy in colon cancer cells. KLF4 overexpression suppresses LC3II/I ratio and autophagosome formation; RAB26 knockdown or rapamycin treatment reverses this effect and restores 5-FU resistance. Luciferase reporter assay for KLF4-RAB26 promoter interaction; RAB26 shRNA knockdown; autophagosome imaging by confocal microscopy; 5-FU resistance assay; xenograft mouse model Cancer biology & therapy Medium 37431852
2023 ROS/cigarette smoke exposure induces DNMT3b-mediated hypermethylation of the Rab26 promoter, suppressing Rab26 expression. Reduced Rab26 activates p38 and JNK MAPK signaling to promote airway epithelial inflammatory mediator production; Rab26 overexpression attenuates this response. Rab26 promoter methylation assay; DNMT3b siRNA; antioxidant (NAC) and DNA methylation inhibitor (5-AZA) treatment; Rab26 overexpression/silencing with p38/JNK phosphorylation readouts; in vivo smoking mouse model Free radical biology & medicine Medium 36610560
2025 Rab26 interacts with angiotensin II Type 1 receptor (AT1R) and promotes its transport to the cell surface in pulmonary artery smooth muscle cells (PASMCs), thereby activating STAT3 and upregulating/promoting nuclear translocation of YAP1, driving PASMC hyper-proliferation under hypoxia. Co-immunoprecipitation of Rab26 with AT1R; Rab26 KO mice (PAH model); pharmacological inhibition of AT1R and pSTAT3; assessment of pSTAT3 and YAP1 levels; pulmonary vascular remodeling histology Cellular and molecular life sciences Medium 41231254
2025 Rab26 deficiency in mice causes depression/anxiety-like behaviors and cognitive impairment. Mechanistically, Rab26 interacts with the serotonin transporter SERT and promotes its autophagic degradation; loss of Rab26 increases cell surface SERT levels, reduces synaptic vesicle turnover (accumulation of SVs at presynaptic terminals), and decreases mEPSC frequency and LTP. Rab26-/- mice; behavioral tests; co-immunoprecipitation of Rab26 with SERT; cell surface SERT measurement; electrophysiology (mEPSC, LTP); electron microscopy of SV accumulation iScience Medium 40687824
2025 Rab26 facilitates lysosomal translocation and degradation of eukaryotic elongation factor 1A (eEF1A) in cardiomyocytes. Cardiac-specific Rab26 overexpression (via AAV9) reduces eEF1A levels, improving cardiac function and reducing hypertrophy; eEF1A silencing eliminates the cardioprotective effect of Rab26. Protein interaction studies (Co-IP/pulldown); fluorescence co-localization of Rab26 and eEF1A with lysosomes; protease inhibition assays; AAV9-cardiac-specific Rab26 overexpression; Rab26 KO; TAC mouse model Life sciences Medium 40609824
2026 Rab26 physically binds to mitochondrial VDAC1 and prevents its oligomerization. Loss of Rab26 promotes VDAC1 oligomerization, mitochondrial membrane permeabilization, and mtDNA leakage into the cytosol, which hyperactivates cGAS-STING signaling, represses SLC7A11/GPX4, and drives ferroptosis in airway epithelial cells exposed to cigarette smoke. Co-immunoprecipitation; chemical cross-linking; transmission electron microscopy; Rab26-/- mice; pharmacological STING inhibition; GPX4/SLC7A11 western blot Free radical biology & medicine Medium 42176907
2026 Rab26 stabilizes EPOR by preventing its ubiquitin-mediated proteasomal degradation; Rab26 deficiency upregulates the E3 ligase BTRC, which interacts with EPOR to promote EPOR degradation. This reduces EPOR levels, suppresses the PPARγ/GPX4 and PINK1-mediated mitophagy axes, and sensitizes macrophages to ferroptosis. Co-IP of BTRC with EPOR; Rab26 KO macrophages; EPOR and BTRC protein level measurement; PPARγ antagonism; mitophagy assays; ferroptosis (lipid peroxidation, GPX4) assays; CLP sepsis mouse model Free radical biology & medicine Medium 42086108

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 The GTPase Rab26 links synaptic vesicles to the autophagy pathway. eLife 149 25643395
2018 RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury. Autophagy 104 29965781
2009 RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. Molecular and cellular biology 91 20038531
2019 SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26. Cell death & disease 56 31511502
2012 Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi. The Journal of biological chemistry 48 23105096
2014 RAB26 coordinates lysosome traffic and mitochondrial localization. Journal of cell science 44 24413166
2000 Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland. Histochemistry and cell biology 41 10857477
2005 Relation of Rab26 to the amylase release from rat parotid acinar cells. Archives of oral biology 38 16076461
2020 Coxiella effector protein CvpF subverts RAB26-dependent autophagy to promote vacuole biogenesis and virulence. Autophagy 35 32116095
2017 Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells. Theranostics 30 28744333
2021 Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src. Cell death & disease 24 33731709
2021 Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury. Frontiers in immunology 23 34925338
2023 ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling. Free radical biology & medicine 22 36610560
2023 KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer. Cancer biology & therapy 19 37431852
2019 Targeted Delivery of Rab26 siRNA with Precisely Tailored DNA Prism for Lung Cancer Therapy. Chembiochem : a European journal of chemical biology 19 30610755
2022 Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons. The Science of the total environment 17 36341850
2023 Rab26 promotes macrophage phagocytosis through regulation of MFN2 trafficking to mitochondria. The FEBS journal 12 37060270
2023 Rab26 restricts insulin secretion via sequestering Synaptotagmin-1. PLoS biology 11 37289842
2023 Rab26 alleviates sepsis-induced immunosuppression as a master regulator of macrophage ferroptosis and polarization shift. Free radical biology & medicine 11 38169213
2022 RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3. Bioengineered 11 35291909
2019 Endothelial Cell Inflammation and Barriers Are Regulated by the Rab26-Mediated Balance between β2-AR and TLR4 in Pulmonary Microvessel Endothelial Cells. Mediators of inflammation 11 31182932
2023 Rab26 controls secretory granule maturation and breakdown in Drosophila. Cellular and molecular life sciences : CMLS 8 36600084
2023 Targeting Rab26 to Conquer Cisplatin-Resistant Lung Cancer with Self-Assembled DNA Nanomaterials. Biomacromolecules 7 37010453
2023 A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease. Gene 5 37931854
2000 cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region. Journal of human genetics 5 11043516
2025 Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis. Acta neuropathologica communications 2 40069888
2025 RAB26 promotes prostate cancer progression via the MAPK/ERK-TWIST1 signaling axis. Genes & diseases 1 40821113
2025 Expression of the genes QPRT, RAB26, and SRPRB in cancer tissue from patients with triple-negative breast cancer as a biomarker for diagnosis, pharmacotherapy strategy, and survival: Evidence from bioinformatic database analysis. International journal of clinical pharmacology and therapeutics 1 40888212
2025 Rab26 promotes hypoxia-induced hyperproliferation of PASMCs by modulating the AT1R-STAT3-YAP axis. Cellular and molecular life sciences : CMLS 1 41231254
2026 Erythropoietin signaling regulated by Rab26 attenuates sepsis-associated lung injury by suppressing macrophage ferroptosis via enhanced mitophagy. Free radical biology & medicine 0 42086108
2026 Rab26 mitigates ferroptosis in airway epithelium induced by cigarette smoke through suppression of VDAC1 oligomerization-mediated cGAS-STING activation. Free radical biology & medicine 0 42176907
2025 Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling. Life sciences 0 40609824
2025 Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter. iScience 0 40687824

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