Affinage

AGTR1

Type-1 angiotensin II receptor · UniProt P30556

Length
359 aa
Mass
41.1 kDa
Annotated
2026-06-09
100 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AGTR1 encodes the angiotensin II type 1 receptor, a G protein-coupled receptor whose abundance at the cell surface and within tissues is set by layered post-transcriptional, post-translational, and epigenetic controls, and whose ligand-activated signaling drives both cardiovascular tone and pro-tumorigenic cell behavior (PMID:18719072, PMID:38160798, PMID:31219799). Surface density is limited post-translationally by CD74, which binds the membrane-proximal AGTR1 C-terminal tail, retains the receptor in the ER, and promotes its proteasomal degradation (PMID:18719072). Receptor levels are also tuned post-transcriptionally by miR-155, which represses AGTR1 through its 3'UTR; the rs5186 A1166C variant disrupts this miR-155 site, relieving repression and elevating receptor protein (PMID:17668390). Transcription is governed by a DNMT/TET methylation switch at the Agtr1a promoter, where loss of CpG methylation in the hypothalamic paraventricular nucleus raises receptor expression and blood pressure, and reciprocal DNMT/TET pharmacological manipulation bidirectionally controls expression and hypertension (PMID:38160798, PMID:36539461). Upon angiotensin II binding, AGTR1 promotes cell migration, invasion, and metastasis via a CXCR4/SDF-1α–FAK/RhoA axis (PMID:31219799, PMID:19487683), transactivates estrogen receptor-α and upregulates aromatase through MAPK signaling (PMID:34572782), and mediates high-glucose-induced β-cell apoptosis through NADPH-oxidase–driven superoxide production (PMID:25512346). In the central amygdala, AGTR1 marks GABAergic CeL neurons and its activation enhances inhibitory transmission to impede fear extinction (PMID:36801399).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1995 Medium

    Establishing the chromosomal positions of the angiotensin receptor gene family provided the genomic anchor needed to link receptor loci to physiological traits.

    Evidence FISH mapping of rat Agtr1a/Agtr1b/Agtr2 and human AGTR2

    PMID:7606933

    Open questions at the time
    • Does not address regulation or function of the human AGTR1 locus
    • No functional consequence of localization established
  2. 2003 Medium

    Whether natural promoter variation could causally control receptor expression and blood pressure was unknown; strain-specific promoter polymorphisms were shown to drive differential Agtr1a mRNA in vivo and reporter expression in vitro.

    Evidence Locus resequencing, in vivo adrenal mRNA quantification, and PC12 luciferase reporters across mouse strains at a chromosome 13 QTL

    PMID:12697907

    Open questions at the time
    • Causal transcription factor binding the polymorphic site not identified
    • Mouse ortholog; human relevance not directly tested
  3. 2007 High

    The functional consequence of the AGTR1 3'UTR rs5186 variant was unresolved; it was shown to disrupt a miR-155 binding site, with the 1166C allele escaping miR-155 repression and yielding higher receptor protein.

    Evidence Allele-specific luciferase silencing assays and endogenous AGTR1 Western blot in matched trisomy 21 vs euploid fibroblasts; allele-specific mRNA quantification in placental cDNA

    PMID:17211857 PMID:17668390

    Open questions at the time
    • In vivo tissue-specific impact of the variant on blood pressure not established
    • Interplay between miR-155 dosage and other regulatory layers unresolved
  4. 2008 High

    How AGTR1 cell-surface density is controlled post-translationally was unknown; CD74 was identified as a C-tail-binding partner that retains AGTR1 in the ER and targets it for proteasomal degradation.

    Evidence Yeast two-hybrid screen with AGTR1 C-tail bait, reciprocal co-IP, co-localization, and surface-density measurement in CHO-K1 cells

    PMID:18719072

    Open questions at the time
    • Physiological tissues where CD74 regulates AGTR1 surface density not defined
    • Whether CD74 retention is signal-regulated unknown
  5. 2009 Medium

    Whether AGTR1 signaling could drive an oncogenic phenotype was untested; ectopic AGTR1 plus angiotensin II conferred an invasive phenotype in mammary epithelial cells reversible by losartan.

    Evidence Ectopic overexpression in primary mammary epithelial cells with Ang II stimulation, losartan antagonism, and breast cancer xenograft growth

    PMID:19487683

    Open questions at the time
    • Downstream effectors of invasion not defined in this study
    • Endogenous AGTR1 dependence in patient tumors not addressed
  6. 2014 Medium

    Additional RNA-level controls of AGTR1 were probed: Tudor-SN was found to bind the AGTR1 3'UTR and modulate the assembly dynamics of AGTR1 mRNA-containing stress granules.

    Evidence Co-localization imaging, Tudor-SN knockdown with fluorescence-recovery kinetics, and co-localization with G3BP-marked stress granules

    PMID:24815690

    Open questions at the time
    • No direct binding reconstitution
    • Functional consequence for AGTR1 protein output not measured
  7. 2014 Medium

    A hormonal link to AGTR1-driven apoptosis was established: testosterone suppresses AGTR1 expression and the resulting NADPH-oxidase superoxide and caspase-3 activation, with siRNA confirming AGTR1 mediates high-glucose β-cell apoptosis.

    Evidence INS-1 cells and mouse islets with testosterone/losartan treatment, AGTR1 siRNA, apoptosis and ROS assays

    PMID:25512346

    Open questions at the time
    • Mechanism by which testosterone represses AGTR1 not defined
    • In vivo relevance to diabetic islet loss not tested
  8. 2019 Medium

    The signaling route for AGTR1-driven metastasis was defined: AGTR1 upregulates CXCR4/SDF-1α to activate FAK/RhoA, promoting migration, invasion, and lymph node metastasis.

    Evidence siRNA knockdown, overexpression, losartan treatment, FAK/RhoA Western blots, Transwell assays, and orthotopic xenograft bioluminescence imaging in breast cancer

    PMID:31219799

    Open questions at the time
    • G protein and immediate-early effectors upstream of CXCR4 induction not mapped
    • Single cancer-type focus
  9. 2020 Medium

    The miR-155–AGTR1 axis was shown to be functionally tumor-suppressive in another cancer: miR-155 represses AGTR1 via its 3'UTR, attenuating NF-κB and CXCR4 signaling and suppressing glioblastoma growth.

    Evidence Luciferase 3'UTR reporter, stable miR-155 overexpression, Western blot, in vitro transformation assays, and xenograft tumor formation

    PMID:32896760

    Open questions at the time
    • Other miR-155 targets contributing to phenotype not excluded
    • Endogenous miR-155/AGTR1 ratio in patient tumors not quantified
  10. 2021 Medium

    Distinct context-dependent AGTR1 signaling outputs were identified: MAPK-mediated aromatase upregulation and ligand-independent ERα transactivation with PD-L1 induction in glioblastoma, and a reported PI3K/AKT3 tumor-suppressive route in lung adenocarcinoma.

    Evidence Aromatase promoter reporters, RT-PCR, Western blot, and losartan antagonism in glioblastoma; overexpression and pathway Western blot in lung adenocarcinoma lines

    PMID:34572782 PMID:34803402

    Open questions at the time
    • The lung adenocarcinoma PI3K/AKT3 finding is low-confidence and lacks mechanistic depth
    • Tissue determinants of pro- vs anti-tumor signaling unresolved
  11. 2023 High

    A central-nervous-system role for AGTR1 was established: AT1R-expressing GABAergic PKCδ+ neurons in the lateral central amygdala mediate angiotensin II-driven inhibition that impedes fear extinction.

    Evidence AT1R reporter mice, cre-lentiviral conditional deletion, immunofluorescence, fear extinction behavior, and whole-cell electrophysiology with Ang II application

    PMID:36801399

    Open questions at the time
    • Downstream circuit targets of CeL-AT1R inhibition not mapped
    • Signaling cascade linking receptor to altered excitability undefined
  12. 2023 High

    The epigenetic transcriptional control of AGTR1 was established as a causal driver of hypertension via a DNMT/TET methylation switch at the promoter.

    Evidence MeDIP, bisulfite-PCR, ChIP-qPCR for DNMT/TET/MBD2, and bidirectional stereotaxic DNMT/TET inhibitor microinjection with blood pressure readouts in SHR vs WKY PVN; maternal-exercise DNMT/methylation modulation in offspring mesenteric arteries

    PMID:36539461 PMID:38160798

    Open questions at the time
    • Upstream signals setting DNMT/TET balance at the promoter unknown
    • Human promoter methylation relevance not directly tested
  13. 2023 Low

    A candidate AGTR1 protein partner in cardiac fluid regulation was reported: AGTR1 physically interacts with aquaporin-1 in failing left ventricle, with the interaction reduced by pharmacological suppression of AGTR1.

    Evidence Co-immunoprecipitation from left ventricular tissue in a rat CHF model with echocardiography and histology

    PMID:36867964

    Open questions at the time
    • Single co-IP without reciprocal validation or reconstitution
    • Functional significance of the AGTR1–AQP1 complex not directly demonstrated

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis by which a single receptor partitions among opposing signaling outputs (pro- vs anti-tumor, GABAergic inhibition, vascular tone) and how its multiple regulatory layers are integrated in vivo remain unresolved.
  • No unified model linking CD74 retention, miR-155, and promoter methylation in a single tissue
  • Determinants of context-dependent effector choice undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0060090 molecular adaptor activity 1
Localization
GO:0005886 plasma membrane 2 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-162582 Signal Transduction 2 R-HSA-112316 Neuronal System 1
Partners
AQP1CD74CXCR4SND1

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 The AGTR1 3'UTR SNP rs5186 (A1166C) disrupts a binding site for hsa-miR-155; the 1166A allele is downregulated by miR-155 in reporter silencing assays, while the 1166C allele abrogates miR-155-mediated repression, resulting in higher AGTR1 protein levels. Fibroblasts from trisomy 21 individuals (with extra miR-155 gene copies) show lower AGTR1 protein than euploid co-twins. Luciferase reporter silencing assay; Western blot of AGTR1 protein in matched trisomy 21 vs. euploid fibroblasts American journal of human genetics High 17668390
2008 CD74 (invariant chain) was identified as an AGTR1-interacting protein via yeast two-hybrid screening of a human kidney cDNA library using the AGTR1 C-terminal tail as bait. The interaction was confirmed by co-immunoprecipitation and co-localization. CD74 binds the membrane-proximal C-terminal tail region previously shown to be required for ER exit, causes retention of AGTR1 in the ER, and promotes its proteasomal degradation, thereby reducing AGTR1 cell-surface density. Yeast two-hybrid screen; co-immunoprecipitation; co-localization; overexpression in CHO-K1 cells with surface density measurement The Journal of endocrinology High 18719072
2014 Tudor-SN (human Tudor staphylococcal nuclease) binds AGTR1 3'UTR RNA and co-localizes with it in stress granules (SGs). Tudor-SN knockdown decreases the recovery kinetics of AGTR1-3'UTR granules, indicating Tudor-SN modulates the dynamics of AGTR1 mRNA-containing SG assembly during stress. Co-localization imaging; Tudor-SN knockdown with fluorescence recovery assay of AGTR1-3'UTR granule kinetics; co-localization with G3BP-marked SGs FEBS letters Medium 24815690
2007 Allele-specific mRNA quantification of AGTR1 transcripts in placental cDNA showed that haplotypes carrying the 1166C allele (rs5186:A>C) have reduced mRNA abundance compared to 1166A haplotypes, with a greater effect in CC homozygotes than heterozygotes, suggesting feedback-regulated allelic mRNA expression at this locus. Quantitative transcript haplotype (QTH) analysis; within-individual ratiometric assays of allelic mRNA in placental cDNA; TaqMan assays Human mutation Medium 17211857
2003 In mice, Agtr1a promoter polymorphisms between BPL/1 and SPRET strains drive strain-specific differences in Agtr1a mRNA abundance in the adrenal gland in vivo, and drive differential luciferase reporter expression when transfected into PC12 chromaffin cells, demonstrating that natural promoter variation functionally controls Agtr1a expression and thereby influences blood pressure at a chromosome 13 QTL. Resequencing of Agtr1a locus; in vivo mRNA quantification; luciferase promoter reporter assays in PC12 cells; genome-wide linkage mapping Physiological genomics Medium 12697907
1995 Using fluorescence in situ hybridization (FISH), the rat Agtr1a gene was mapped to chromosome 17q12, Agtr1b to 2q24, Agtr2 to Xq34, and human AGTR2 to Xq22, establishing the chromosomal localization of these receptor genes. Fluorescence in situ hybridization (FISH) Cytogenetics and cell genetics Medium 7606933
2019 AGTR1 overexpression in breast cancer cells upregulates CXCR4/SDF-1α and activates FAK/RhoA signaling to promote cell migration, invasion, and lymph node metastasis. Knockdown of AGTR1 reduced CXCR4 expression; knockdown of CXCR4 in AGTR1-high cells downregulated FAK/RhoA signaling molecules; losartan (AGTR1 antagonist) decreased CXCR4/SDF-1α levels in vivo and inhibited migration and invasion in vitro. siRNA knockdown; AGTR1 overexpression; losartan treatment; bioluminescence imaging of orthotopic xenografts; Western blot of FAK/RhoA pathway; Transwell migration/invasion assays Aging Medium 31219799
2009 Ectopic overexpression of AGTR1 in primary mammary epithelial cells combined with angiotensin II stimulation induces a highly invasive phenotype; this invasion is attenuated by the AGTR1 antagonist losartan. Losartan also reduced tumor growth by 30% in AGTR1-positive breast cancer xenografts. Ectopic overexpression in primary mammary epithelial cells; angiotensin II stimulation; losartan antagonism; breast cancer xenograft tumor growth assay Proceedings of the National Academy of Sciences of the United States of America Medium 19487683
2020 miR-155 post-transcriptionally represses AGTR1 via its 3'UTR (confirmed by luciferase reporter assay) in glioblastoma cells. miR-155 overexpression reduces AGTR1 protein, attenuates NF-κB signaling downstream of AGTR1, and decreases CXCR4 and AGTR1 levels, reducing GBM cell proliferation, invasion, foci formation, and anchorage-independent growth; stable miR-155-overexpressing cells form negligible tumors in immunodeficient mice. Luciferase reporter assay of AGTR1 3'UTR; miR-155 stable overexpression; Western blot; in vitro cell assays; xenograft tumor model Neoplasia (New York, N.Y.) Medium 32896760
2014 Testosterone reduces AGTR1 mRNA and protein expression in INS-1 pancreatic β-cells cultured in high-glucose medium, decreases p47phox mRNA/protein and superoxide production, and reduces cleaved caspase-3 and apoptosis to levels similar to losartan. AGTR1 siRNA knockdown confirmed that AGTR1 mediates high-glucose-induced β-cell apoptosis; testosterone did not alter AGTR1 expression or apoptosis under basal glucose conditions. INS-1 cell culture and isolated mouse islets; testosterone and losartan treatment; AGTR1 siRNA knockdown; RT-PCR and Western blot; annexin V/PI apoptosis assay; superoxide/ROS measurement The Journal of endocrinology Medium 25512346
2023 In the central amygdala (CeA) of mice, AT1R (AGTR1)-expressing neurons are localized to GABAergic neurons in the lateral CeA (CeL), the majority co-expressing PKCδ. Conditional CeA-AT1R deletion (via cre-expressing lentiviral delivery in AT1R-Flox mice) enhanced fear extinction acquisition without altering anxiety, locomotion, or fear acquisition. Electrophysiological recordings showed that angiotensin II (1 μM) increased sIPSC amplitude and decreased excitability of CeL-AT1R+ neurons, indicating AGTR1 activation facilitates GABAergic inhibition in the CeL to impede extinction learning. Transgenic AT1R reporter mice; cre-lentiviral conditional deletion; immunofluorescence co-localization; fear conditioning/extinction behavioral assays; whole-cell electrophysiology of CeL neurons with Ang II application Neuropharmacology High 36801399
2023 In spontaneously hypertensive rats (SHR), CpG methylation at the Agtr1a promoter in the hypothalamic paraventricular nucleus (PVN) is progressively reduced compared to normotensive WKY rats, correlating with increased Agtr1a mRNA. ChIP-qPCR showed reduced DNMT1/DNMT3A and MBD2 enrichment, and increased TET1-3 enrichment, at the Agtr1a promoter in SHR. Microinjection of DNMT inhibitor RG108 into WKY PVN raised blood pressure and elevated Agtr1a mRNA; microinjection of TET inhibitor C35 into SHR PVN reduced blood pressure and Agtr1a mRNA, establishing a DNMT/TET epigenetic switch as a mechanistic driver of Agtr1a transcription and hypertension. Methylated DNA immunoprecipitation; bisulfite sequencing-PCR; ChIP-qPCR; stereotaxic microinjection of DNMT/TET inhibitors; arterial blood pressure measurement; RT-qPCR The Journal of biological chemistry High 38160798
2022 Maternal exercise in spontaneously hypertensive rat dams upregulates DNMT1 and DNMT3B expression in mesenteric arteries of offspring, increases CpG methylation at the Agtr1a promoter, reduces AT1R (AGTR1) mRNA and protein expression, decreases Ang II-AT1R-mediated vascular tone, and lowers blood pressure in adult SHR offspring. Bisulfite sequencing of Agtr1a promoter; Western blot and RT-PCR of AT1R; arterial vascular tone measurements; blood pressure telemetry in offspring Hypertension research : official journal of the Japanese Society of Hypertension Medium 36539461
2023 Co-immunoprecipitation in a rat CHF model demonstrated a physical interaction between AGTR1 and aquaporin-1 (AQP1) in the left ventricle. XinLi formula treatment inhibited AGTR1 expression and suppressed the AGTR1–AQP1 interaction, reducing myocardial edema, suggesting the AGTR1–AQP1 complex contributes to cardiac fluid regulation. Co-immunoprecipitation from left ventricular tissue; Western blot; echocardiography; ELISA; histology Phytomedicine : international journal of phytotherapy and phytopharmacology Low 36867964
2021 In glioblastoma cells (U-87 MG and T98G), Ang II/AGTR1 signaling directly upregulates aromatase gene promoters p I.f and p I.4, increasing local estrogen production, and transactivates estrogen receptor-α in a ligand-independent manner through MAPK activation. Ang II treatment also increases PD-L1 expression, reversible by losartan in vitro and in vivo. Aromatase promoter reporter assays; RT-PCR; Western blot; losartan pharmacological antagonism; in vivo tumor model Cancers Medium 34572782
2021 In vitro enrichment analysis and overexpression experiments in lung adenocarcinoma cell lines indicated that AGTR1 inhibits tumor progression through the PI3K/AKT3 pathway, supported by AGTR1 overexpressing cell construction and tissue sample validation. AGTR1 overexpression in cell lines; Western blot of PI3K/AKT3 pathway; enrichment analysis; tissue sample protein measurement Cancer management and research Low 34803402

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Ag2S quantum dot: a bright and biocompatible fluorescent nanoprobe in the second near-infrared window. ACS nano 417 22515909
2007 Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. American journal of human genetics 302 17668390
2009 AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proceedings of the National Academy of Sciences of the United States of America 138 19487683
2018 Glutathione-Capped Ag2S Nanoclusters Inhibit Coronavirus Proliferation through Blockage of Viral RNA Synthesis and Budding. ACS applied materials & interfaces 103 29337529
2010 Real-time in situ HRTEM-resolved resistance switching of Ag2S nanoscale ionic conductor. ACS nano 94 20397627
2014 RuSi@Ru(bpy)3(2+)/Au@Ag2S nanoparticles electrochemiluminescence resonance energy transfer system for sensitive DNA detection. Analytical chemistry 70 24707967
2014 Low-toxic Ag2S quantum dots for photoelectrochemical detection glucose and cancer cells. Biosensors & bioelectronics 69 24525014
2017 The miR-34a-5p promotes the multi-chemoresistance of osteosarcoma via repression of the AGTR1 gene. BMC cancer 58 28073349
2012 SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer. Breast cancer research and treatment 52 23203637
2013 Ag2S quantum dots conjugated chitosan nanospheres toward light-triggered nitric oxide release and near-infrared fluorescence imaging. Langmuir : the ACS journal of surfaces and colloids 51 24224470
2022 Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease. PloS one 50 35120165
2016 Albumin-Mediated Biomineralization of Paramagnetic NIR Ag2S QDs for Tiny Tumor Bimodal Targeted Imaging in Vivo. ACS applied materials & interfaces 48 27300300
2016 Near-Infrared Ag2S Quantum Dots-Based DNA Logic Gate Platform for miRNA Diagnostics. Analytical chemistry 47 27368143
2004 Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. The American journal of the medical sciences 43 15545843
2019 AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion. Aging 42 31219799
2014 Characterization of tumor-targeting Ag2S quantum dots for cancer imaging and therapy in vivo. Nanoscale 41 25184523
2015 Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension. Orphanet journal of rare diseases 39 25603901
2021 Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study. Translational medicine communications 36 34805533
2014 Generation of Multiple Excitons in Ag2S Quantum Dots: Single High-Energy versus Multiple-Photon Excitation. The journal of physical chemistry letters 36 26270833
2012 ACACβ gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes. Molecular and cellular biochemistry 35 23081748
2015 Highly luminescent and cytocompatible cationic Ag2S NIR-emitting quantum dots for optical imaging and gene transfection. Nanoscale 34 26068022
2011 A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of molecular and cellular cardiology 33 21771600
2009 Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 32 19332265
2022 Chiral NIR-II fluorescent Ag2S quantum dots with stereospecific biological interactions and tumor accumulation behaviors. Science bulletin 31 36546157
2008 Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan. The Annals of pharmacotherapy 31 18594050
2020 Targeting AGTR1/NF-κB/CXCR4 axis by miR-155 attenuates oncogenesis in glioblastoma. Neoplasia (New York, N.Y.) 30 32896760
2018 Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors. Nanoscale 30 30151510
2013 Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic population. PloS one 30 23484035
2022 NIR-activated multi-hit therapeutic Ag2S quantum dot-based hydrogel for healing of bacteria-infected wounds. Acta biomaterialia 29 35429669
2014 Dual targeting of angiotensin receptors (AGTR1 and AGTR2) in epithelial ovarian carcinoma. Gynecologic oncology 29 25014541
2004 Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia. Human mutation 29 15221785
2019 Bypassing pro-survival and resistance mechanisms of autophagy in EGFR-positive lung cancer cells by targeted delivery of 5FU using theranostic Ag2S quantum dots. Journal of materials chemistry. B 28 31696188
2018 A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots. Talanta 28 30609564
2012 AGTR1 gene variation: association with depression and frontotemporal morphology. Psychiatry research 28 22703619
2010 ACE and AGTR1 polymorphisms and left ventricular hypertrophy in endurance athletes. Medicine and science in sports and exercise 26 19997001
2018 Association of AGTR1 (A1166C) and ACE (I/D) Polymorphisms with Breast Cancer Risk in North Indian Population. Translational oncology 25 29413755
2015 Association of AGTR1 Promoter Methylation Levels with Essential Hypertension Risk: A Matched Case-Control Study. Cytogenetic and genome research 25 26658476
2019 L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways. Bioscience reports 24 30975734
2021 LINC00852 promotes the proliferation and invasion of ovarian cancer cells by competitively binding with miR-140-3p to regulate AGTR1 expression. BMC cancer 23 34496800
2020 Evaluation of the biocompatibility of the GSH-coated Ag2S quantum dots in vitro: a perfect example for the non-toxic optical probes. Molecular biology reports 22 32436042
2020 A signal amplification of p DNA@Ag2S based photoelectrochemical competitive sensor for the sensitive detection of OTA in microfluidic devices. Biosensors & bioelectronics 22 32866723
2018 Qiliqiangxin Rescues Mouse Cardiac Function by Regulating AGTR1/TRPV1-Mediated Autophagy in STZ-Induced Diabetes Mellitus. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 22 29929188
2014 A polymorphism in AGT and AGTR1 gene is associated with lead-related high blood pressure. Journal of the renin-angiotensin-aldosterone system : JRAAS 22 25031294
2014 Testosterone reduces AGTR1 expression to prevent β-cell and islet apoptosis from glucotoxicity. The Journal of endocrinology 22 25512346
2012 Visible to near-infrared light harvesting in Ag2S nanoparticles/ZnO nanowire array photoanodes. Nanoscale 22 22278401
2010 Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the Multi-ethnic Study of Atherosclerosis. American journal of nephrology 22 20606419
1995 Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22. Cytogenetics and cell genetics 22 7606933
2015 PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease. International journal of clinical and experimental pathology 21 26045830
2014 Genotoxic effects of CdS quantum dots and Ag2S nanoparticles in fish cell lines (RTG-2). Mutation research. Genetic toxicology and environmental mutagenesis 21 25435359
2010 Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects. American journal of hypertension 21 20864943
2017 AGTR1 promoter hypermethylation in lung squamous cell carcinoma but not in lung adenocarcinoma. Oncology letters 20 29085512
2006 Increased expression of angiotensin II type 1 receptor (AGTR1) in heart transplant recipients with recurrent rejection. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20 17097490
2014 Human Tudor staphylococcal nuclease (Tudor-SN) protein modulates the kinetics of AGTR1-3'UTR granule formation. FEBS letters 19 24815690
2023 Enzyme/GSH/pH-responsive hyaluronic acid grafted porous silica nanocarriers bearing Ag2S QDs for fluorescence imaging and combined therapy. Carbohydrate polymers 18 36737216
2017 Hypomethylation of the Angiotensin II Type I Receptor (AGTR1) Gene Along with Environmental Factors Increases the Risk for Essential Hypertension. Cardiology 18 28376480
2015 Cyto/hemocompatible magnetic hybrid nanoparticles (Ag2S-Fe3O4) with luminescence in the near-infrared region as promising theranostic materials. Colloids and surfaces. B, Biointerfaces 18 26101820
2012 Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction. Cytokine 18 22433249
2012 Association of maternal AGTR1 polymorphisms and preeclampsia: a systematic review and meta-analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 18 22758920
2007 Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Human mutation 18 17211857
2022 Downregulation of ACE, AGTR1, and ACE2 genes mediating SARS-CoV-2 pathogenesis by gut microbiota members and their postbiotics on Caco-2 cells. Microbial pathogenesis 17 36174833
2018 Interpreting the effects of natural organic matter on antimicrobial activity of Ag2S nanoparticles with soft particle theory. Water research 17 30118974
2008 Identification of the invariant chain (CD74) as an angiotensin AGTR1-interacting protein. The Journal of endocrinology 17 18719072
2007 Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy. American journal of hypertension 17 17903694
2021 A self-assembled nanoplatform based on Ag2S quantum dots and tellurium nanorods for combined chemo-photothermal therapy guided by H2O2-activated near-infrared-II fluorescence imaging. Acta biomaterialia 16 34923095
2019 Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect. Nanomedicine (London, England) 16 30917096
2015 Origin of Unusual Excitonic Absorption and Emission from Colloidal Ag2S Nanocrystals: Ultrafast Photophysics and Solar Cell. The journal of physical chemistry letters 16 26722893
2009 Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects. Clinical biochemistry 16 19833117
2014 A facile cation exchange-based aqueous synthesis of highly stable and biocompatible Ag₂S quantum dots emitting in the second near-infrared biological window. Dalton transactions (Cambridge, England : 2003) 15 25270003
2012 Association of left ventricular mass with the AGTR1 A1166C polymorphism. American journal of hypertension 15 22237156
2010 Investigation of ACE, ACE2 and AGTR1 genes for association with nephropathy in Type 1 diabetes mellitus. Diabetic medicine : a journal of the British Diabetic Association 15 20854388
2009 Multilocus analysis in candidate genes ACE, AGT, and AGTR1 and predisposition to peripheral arterial disease: role of ACE D/-240T haplotype. Journal of vascular surgery 15 19782519
2009 Gene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 15 20560294
2023 Central amygdala angiotensin type 1 receptor (Agtr1) expressing neurons contribute to fear extinction. Neuropharmacology 14 36801399
2017 Association and Interaction Effect of AGTR1 and AGTR2 Gene Polymorphisms with Dietary Pattern on Metabolic Risk Factors of Cardiovascular Disease in Malaysian Adults. Nutrients 14 28792482
2017 Association of AGTR1 and ACE2 gene polymorphisms with structural atrial fibrillation in a Chinese Han population. Die Pharmazie 14 29441892
2013 Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial. Journal of the American Society of Hypertension : JASH 14 24131669
2007 Association of AGTR1 with 18-month treatment outcome in late-life depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 14 17586781
2023 XinLi formula, a traditional Chinese decoction, alleviates chronic heart failure via regulating the interaction of AGTR1 and AQP1. Phytomedicine : international journal of phytotherapy and phytopharmacology 13 36867964
2023 Image-Guided Enhanced PDT/PTT Combination Therapy Using Brominated Hemicyanine-Loaded Folate Receptor-Targeting Ag2S Quantum Dots. Bioconjugate chemistry 13 37078275
2023 DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development. The Journal of biological chemistry 13 38160798
2022 Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan. International journal of hypertension 13 35345577
2022 Maternal exercise upregulates the DNA methylation of Agtr1a to enhance vascular function in offspring of hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension 13 36539461
2021 AGTR1 Inhibits the Progression of Lung Adenocarcinoma. Cancer management and research 13 34803402
2016 High-temperature X-ray diffraction and thermal expansion of nanocrystalline and coarse-crystalline acanthite α-Ag2S and argentite β-Ag2S. Physical chemistry chemical physics : PCCP 13 26796061
2003 The angiotensin II receptor (Agtr1a): functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse. Physiological genomics 13 12697907
2021 LINC00665 functions as a competitive endogenous RNA to regulate AGTR1 expression by sponging miR‑34a‑5p in glioma. Oncology reports 12 33650673
2021 Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells. Cancers 12 34572782
2024 Interfacing Ag2S Nanoparticles and MoS2 Nanosheets on Polypyrrole Nanotubes with Enhanced Catalytic Performance. Inorganic chemistry 11 38372243
2023 Near-infrared-II Ag2S quantum dot probes targeting podoplanin enhance immunotherapy in oral squamous cell carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 11 38157644
2021 Distributive characteristics of the CYP2C9 and AGTR1 genetic polymorphisms in Han Chinese hypertensive patients: a retrospective study. BMC cardiovascular disorders 11 33541272
2018 Association between 3'UTR polymorphisms in genes ACVR2A, AGTR1 and RGS2 and preeclampsia. General physiology and biophysics 10 29593124
2002 A method for developing high-density SNP maps and its application at the type 1 angiotensin II receptor (AGTR1) locus. Genomics 10 11863362
2022 Fabrication of a smart drug delivery system based on hollow Ag2S@mSiO2 nanoparticles for fluorescence-guided synergistic photothermal chemotherapy. Mikrochimica acta 9 36074274
2019 Multifunctional A7R Peptide-Modified Hollow Mesoporous Silica@Ag₂S Nanotheranostics for Photoacoustic/Near-Infrared Fluorescence Imaging-Guided Tumor-Targeted Chemo-Photothermal Therapy. Journal of biomedical nanotechnology 9 31196347
2019 Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study. Asian Pacific journal of cancer prevention : APJCP 9 31554351
2017 Interactions Between PPARG and AGTR1 Gene Polymorphisms on the Risk of Hypertension in Chinese Han Population. Genetic testing and molecular biomarkers 9 29266977
2014 Toxic potential of iron oxide, CdS/Ag₂S composite, CdS and Ag₂S NPs on a fresh water alga Mougeotia sp. Colloids and surfaces. B, Biointerfaces 9 25465759
2008 Observation of rotated-oriented attachment during the growth of Ag2S nanorods under mediation of protein. The journal of physical chemistry. B 9 18646794
2019 AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease. Irish journal of medical science 8 31858452
2016 AGTR1 rs3772622 gene polymorphism increase the risk of nonalcoholic fatty liver disease patients suffer coronary artery disease in Northern Chinese Han population. Lipids in health and disease 8 27342049

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