Affinage

RAB11FIP1

Rab11 family-interacting protein 1 · UniProt Q6WKZ4

Length
1283 aa
Mass
137.2 kDa
Annotated
2026-04-28
88 papers in source corpus 23 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB11FIP1 (RCP) is a Rab11 effector that functions as a master regulator of membrane cargo recycling at tubular recycling endosomes, directing diverse transmembrane proteins—including transferrin receptor, integrins, PAR1, P-glycoprotein, MUC13, and polymeric immunoglobulin receptor—back to the plasma membrane or, via interaction with Golgin-97, to the trans-Golgi network (PMID:11786538, PMID:15181150, PMID:20610657, PMID:35819177). Its C2 domain binds phosphatidic acid generated by DGKα, tethering RCP-positive vesicles at invasive pseudopod tips where α5β1 integrin recycling activates an Akt→RacGAP1 signaling cascade that switches Rac-to-RhoA activity and promotes tumor cell invasion (PMID:22270919, PMID:24019536). RCP stabilizes β1 integrin protein levels, engaging ILK/EGFR/Ras/NF-κB and STAT3/Slug pathways to drive epithelial-to-mesenchymal transition and metastasis, while its transcription is upregulated by gain-of-function mutant p53 through Sp1/Sp3 (PMID:27524413, PMID:35256783). Global knockout in mice causes spontaneous colonic inflammation with defective apical membrane trafficking and goblet cell loss, establishing an in vivo requirement for mucosal homeostasis (PMID:35819177).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2002 High

    Identifying RCP as a dual Rab4/Rab11 effector that controls endosomal recycling established the gene's foundational molecular function and linked it to the transferrin recycling pathway.

    Evidence Co-IP, dominant-negative overexpression, and quantitative recycling assays in cultured cells

    PMID:11786538 PMID:11944901

    Open questions at the time
    • Relative functional contributions of Rab4 versus Rab11 binding were unclear
    • Physiological cargo beyond transferrin receptor unknown
    • No structural data on Rab–RCP interaction
  2. 2004 High

    Demonstrating that Rab11—not Rab4—is the primary functional partner resolved the ambiguity of the dual effector model and showed that RCP sorts cargo from degradative to recycling routes.

    Evidence In vitro binding assays, site-directed mutagenesis of the RBD, and in vivo transport assays

    PMID:15181150 PMID:15280022

    Open questions at the time
    • Other Rab partners (e.g., Rab14, Rab25) not yet tested
    • Mechanism of sorting decision at the endosome unresolved
  3. 2006 Medium

    Characterizing eight RAB11FIP1 splice isoforms and showing that only isoforms retaining the C-terminal RBD localize to Rab11-positive membranes revealed isoform-specific functional specialization within the recycling system.

    Evidence Molecular cloning, EGFP-fusion imaging, and endogenous antibody staining

    PMID:16920206

    Open questions at the time
    • Functional differences among RBD-containing isoforms (A–D) were not established
    • Tissue-specific isoform expression not characterized
  4. 2009 High

    Showing that RCP overexpression confers tumorigenicity and RCP knockdown blocks invasion and xenograft growth established RCP as an oncogenic driver acting through ERK/Ras activation.

    Evidence Stable overexpression/knockdown in breast cancer lines, in vitro colony and invasion assays, mouse xenograft

    PMID:19620787

    Open questions at the time
    • Upstream regulators of RCP expression in cancer unknown
    • Which recycling cargo mediates oncogenic signaling not defined
  5. 2010 High

    Discovery that RCP and Rab11 mediate retrograde transport to the TGN via interaction with Golgin-97 expanded RCP's trafficking role beyond plasma membrane recycling to include endosome-to-TGN routing.

    Evidence Proteomic identification of Golgin-97 as RCP partner, domain mapping, functional transport assays with TGN38 and Shiga toxin

    PMID:20610657

    Open questions at the time
    • How RCP distinguishes retrograde versus recycling cargo unclear
    • Whether Golgin-97 interaction is regulated by post-translational modification unknown
  6. 2012 High

    Demonstrating that DGKα-generated phosphatidic acid tethers RCP at pseudopod tips via its C2 domain linked lipid signaling to integrin recycling and invasive migration.

    Evidence DGKα mutants, RCP C2-domain deletion, 3D invasion assays, and subcellular localization

    PMID:22270919

    Open questions at the time
    • Structural basis of C2 domain–PA interaction not resolved
    • Whether other lipid species regulate RCP tethering untested
  7. 2013 High

    Identification of the Akt→RacGAP1 phosphorylation cascade downstream of RCP-driven α5β1 recycling revealed the molecular mechanism by which RCP coordinates a Rac-to-RhoA switch at pseudopod tips to drive invasion.

    Evidence Phosphoproteomics, Co-IP, knockdown/rescue, live-cell imaging, 3D invasion assays

    PMID:24019536

    Open questions at the time
    • Whether RCP directly scaffolds Akt or acts indirectly through integrin clustering not distinguished
    • Contribution of this pathway to in vivo metastasis not tested
  8. 2015 High

    Crystal structure of Rab14–RCP RBD complex revealed a noncanonical 1:2 stoichiometry and lower affinity versus Rab11, and both RCP and Rab14 were shown to function in neuritogenesis, broadening the Rab partner repertoire.

    Evidence X-ray crystallography, ITC, yeast two-hybrid, neuritogenesis assay

    PMID:26032412

    Open questions at the time
    • Functional significance of the 1:2 stoichiometry in vivo unclear
    • Whether Rab14 and Rab11 compete for RCP on the same membrane not resolved
  9. 2016 High

    Showing that RCP stabilizes β1 integrin to engage an ILK/EGFR/NF-κB/Slug cascade defined a mechanistic link between RCP-mediated recycling and epithelial-to-mesenchymal transition.

    Evidence Ectopic expression, siRNA epistasis with pathway inhibitors, in vivo lung metastasis model

    PMID:27524413

    Open questions at the time
    • Mechanism by which RCP stabilizes β1 integrin protein levels not identified
    • Whether this pathway operates in non-breast cancer contexts untested
  10. 2017 High

    Identifying MARK2 phosphorylation of RCP at S234 and its requirement for correct lumen positioning linked RCP to epithelial polarity regulation beyond trafficking.

    Evidence In vitro kinase assay, phospho-mutant overexpression, calcium-switch polarity assay in MDCK cells

    PMID:28396819

    Open questions at the time
    • How S234 phosphorylation alters RCP conformation or partner binding unknown
    • Relevance to in vivo epithelial morphogenesis not tested
  11. 2020 High

    Demonstrating that mutant p53 co-opts RCP to drive Hsp90α exosomal secretion and P-glycoprotein surface delivery connected RCP trafficking to chemoresistance mechanisms.

    Evidence MS identification, knockdown/rescue, vesicle trafficking and drug retention assays

    PMID:32640214 PMID:33627632

    Open questions at the time
    • Whether RCP directly recognizes P-gp or uses an adaptor unknown
    • Contribution of exosomal Hsp90α to in vivo tumor microenvironment remodeling not established
  12. 2021 High

    Dual findings that RCP suppresses EMT by inhibiting Zeb1 and facilitates pIgA transcytosis via TRIM21-mediated ubiquitination expanded RCP's roles into epithelial barrier integrity and mucosal immunity.

    Evidence RNA-seq, 3D organoids, siRNA, invasion assays (EMT); Co-IP, ubiquitination assays, transcytosis assays (pIgA)

    PMID:33403789 PMID:34638806

    Open questions at the time
    • Whether RCP's anti-EMT function is independent of its recycling activity not resolved
    • Whether K11 ubiquitination activates RCP or targets it for degradation in specific contexts unclear
  13. 2022 Medium

    Revealing that mutant p53 transcriptionally upregulates RCP via Sp1/Sp3 and that downstream STAT3 activation drives invasion closed the loop on how RCP expression is elevated in cancer and which signaling cascades mediate its pro-invasive effects.

    Evidence ChIP, reporter assays, MS-based TF identification, epistasis with STAT3 inhibition

    PMID:35256783 PMID:35809175 PMID:35819177

    Open questions at the time
    • Whether Sp1/Sp3-dependent transcription operates in non-cancer tissues unknown
    • Global knockout mouse phenotype focused on colon; other organ phenotypes not characterized

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for how RCP selects among diverse cargo, whether the anti-EMT and pro-invasion roles are context-dependent or represent distinct isoform functions, and the in vivo contribution of MARK2 phosphorylation to tissue morphogenesis.
  • No full-length RCP structure available
  • Cargo selection mechanism not defined at molecular level
  • Isoform-specific functions in vivo not resolved
  • Relationship between S234 phosphorylation and oncogenic signaling untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5 GO:0008289 lipid binding 1
Localization
GO:0005768 endosome 4 GO:0005886 plasma membrane 3 GO:0031410 cytoplasmic vesicle 3
Pathway
R-HSA-5653656 Vesicle-mediated transport 7 R-HSA-162582 Signal Transduction 4 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-1500931 Cell-Cell communication 2
Partners
DGKAGOLGA4ITGB1MARK2RAB11ARAB14RACGAP1TRIM21

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 RAB11FIP1/RCP is a dual Rab4 and Rab11 effector protein; overexpression of its C-terminal Rab-binding region causes dramatic tubulation of the transferrin compartment and significantly reduces endosomal recycling without affecting ligand uptake or degradation, identifying it as a regulator of the receptor recycling pathway. Co-immunoprecipitation, overexpression dominant-negative mutant, quantitative recycling assays, subcellular colocalization with early endosomal markers The Journal of biological chemistry High 11786538
2004 The RCP-Rab11 complex regulates sorting of transferrin receptors from the degradative to the recycling pathway in tubular endosomes; RCP interacts only weakly with Rab4 in vitro and Rab11, not Rab4, is the primary functional partner for RCP in vivo. In vitro binding assays, in vivo functional transport assays, colocalization, dominant-negative expression Molecular biology of the cell High 15181150
2004 Site-directed mutagenesis of the conserved Rab-binding domain (RBD) of RCP demonstrated that Rab11 (not Rab4) mediates the intracellular localization of RCP, and that class I Rab11-FIPs compete for binding to Rab11. Site-directed mutagenesis, binding assays, subcellular localization FEBS letters High 15280022
2002 RAB11FIP1/RCP family members display extensive homo- and hetero-interactions mediated primarily by their C-terminal Rab-binding domain/ERM motif, suggesting protein 'platforms' regulated by Rab11 and/or Rab4 activity; two members (pp75/Rip11 and Rab11-FIP3) do not bind Rab4. Co-immunoprecipitation, yeast two-hybrid, binding assays Biochemical and biophysical research communications Medium 11944901
2010 FIP1/RCP (RAB11FIP1) and Rab11a/b are required for retrograde transport of TGN38 and Shiga toxin from early/recycling endosomes to the trans-Golgi network; proteomic analysis identified Golgin-97 as a FIP1/RCP-binding protein, with the binding domain mapping to the C-terminus of Golgin-97, and this interaction regulates tethering/fusion of retrograde transport vesicles to the TGN. Fluorescence and electron microscopy, functional transport assays, proteomic/MS analysis, co-immunoprecipitation domain mapping Molecular biology of the cell High 20610657
2012 Diacylglycerol kinase α (DGK-α) generates phosphatidic acid (PA) that is required for RCP to be mobilized to and tethered at the tips of invasive pseudopods; an RCP mutant lacking the PA-binding C2 domain cannot be tethered at pseudopod tips and fails to drive α5β1 recycling and tumor cell invasion. Dominant-negative and constitutively active DGK-α expression, RCP C2-domain deletion mutant, 3D invasion assays, subcellular localization imaging The Journal of cell biology High 22270919
2013 RCP-driven α5β1 integrin recycling activates PKB/Akt, which phosphorylates RacGAP1; phospho-RacGAP1 is recruited to IQGAP1 at invasive pseudopod tips, locally suppressing Rac and promoting RhoA activity, thereby driving pseudopod extension and invasive migration into fibronectin-containing ECM. Phosphoproteomic identification of PKB/Akt substrates, Co-IP, knockdown/rescue, live-cell imaging, 3D invasion assays The Journal of cell biology High 24019536
2009 RCP/RAB11FIP1 overexpression in MCF10A cells confers tumorigenic properties and enhances ERK phosphorylation and Ras activation; RCP knockdown in breast cancer cell lines inhibits invasion, migration, and tumor formation in xenograft models. Stable overexpression and knockdown, in vitro colony/invasion/migration assays, mouse xenograft, ERK/Ras activity assays The Journal of clinical investigation High 19620787
2015 Crystal structure of Rab14 in complex with the RCP Rab-binding domain reveals that Rab14 binds RCP with reduced affinity relative to Rab11/25, with a noncanonical 1:2 stoichiometry; in vivo, Rab11 recruits RCP onto biological membranes, and both RCP and Rab14 function in neuritogenesis. X-ray crystallography, isothermal titration calorimetry, yeast two-hybrid, cell-based neuritogenesis assay The Journal of biological chemistry High 26032412
2017 MARK2 kinase phosphorylates Rab11-FIP1B/C at serine 234; overexpression of a non-phosphorylatable Rab11-FIP1C(S234A) mutant in MDCK cells causes lateral lumen formation and reorientation of centrosome and Golgi, revealing a role for FIP1 phosphorylation in regulating epithelial polarity downstream of MARK2. In vitro kinase assay, phospho-specific antibodies, mutant overexpression, immunofluorescence microscopy, calcium-switch polarity assay Cellular logistics High 28396819
2016 RCP stabilizes β1 integrin protein levels, leading to activation of an ILK/EGFR/Ras/NF-κB signaling cascade and subsequent Slug induction, epithelial-to-mesenchymal transition, and increased cancer cell invasion; β1 integrin silencing blocks RCP-induced Slug expression. Ectopic expression, siRNA knockdown, pharmacological inhibitors, dominant-negative Ras, in vivo lung metastasis assay Oncogene High 27524413
2021 RAB11FIP1 directly inhibits Zeb1 expression to suppress EMT; genetic knockdown of Rab11-FIP1 decreases E-cadherin, increases mesenchymal markers, increases Zeb1, and promotes invasion in 3D organoid models and human ESCC cell lines. RNA-seq, 3D organoid modeling, siRNA knockdown, invasion assays, marker immunostaining EMBO reports High 33403789
2020 Mutant p53 enhances Hsp90α vesicular trafficking and exosome-mediated secretion through RCP; RCP knockdown decreases extracellular Hsp90α levels and inhibits invasion, and recombinant Hsp90α rescues impaired migration caused by RCP depletion. Mass spectrometry identification, knockdown/rescue, vesicle trafficking assays, migration/invasion assays Cell reports High 32640214
2021 RCP interacts with P-glycoprotein (P-gp); in mutant p53 cells, RCP mediates delivery of P-gp to the plasma membrane upon drug treatment, decreasing intracellular drug retention and conferring chemoresistance; loss of RCP or mutant p53 sensitizes cells to cisplatin and etoposide. Protein screen (interactome), endogenous Co-IP, knockdown, plasma membrane fractionation, drug retention assays Cell death & disease High 33627632
2021 Rab11-FIP1 and Rab11-FIP5 cooperatively facilitate polymeric IgA (pIgA) transcytosis; TRIM21 mediates K11-linked polyubiquitination of Rab11-FIP1 and K6-linked polyubiquitination of Rab11-FIP5 to promote their activation and pIgA transcytosis in epithelial cells. Co-IP, knockdown, ubiquitination assays, transcytosis functional assays in polarized/incompletely polarized cells International journal of molecular sciences Medium 34638806
2022 Global Rab11FIP1 knockout mice develop spontaneous colonic inflammation, show decreased TFF3-positive goblet cells, abnormal accumulation of subapical vesicles in colonocytes, and internalization of transmembrane mucin MUC13 with Rab14; after DSS treatment, KO mice exhibit greater mucosal damage, revealing RCP's role in colonic mucosal cytoprotection. Global knockout mouse model, immunostaining, RNA-seq, DSS colitis model, subcellular vesicle analysis American journal of physiology. Gastrointestinal and liver physiology High 35819177
2020 Thrombin-induced PAR1 internalization and lysosomal targeting requires disassembly of the Rab11a/RCP complex, which depends on thrombin-induced intracellular calcium increase and calpain activation. Fluorescence imaging, calpain inhibition, calcium chelation, Co-IP, internalization assays Cellular signalling Medium 32860953
2006 The RAB11FIP1 gene encodes eight alternatively spliced transcripts; isoforms containing the C-terminal Rab11-binding domain (A-D) target to Rab11a-containing membranes, while isoforms lacking this domain (E/F/H) do not. Endogenous Rab11-FIP1C/RCP resides in a differentiable subcellular compartment within the recycling system compared to FIP1A and FIP1B. Molecular cloning, EGFP-fusion overexpression, immunofluorescence colocalization, antibody staining of endogenous protein Biochimica et biophysica acta Medium 16920206
2018 RCP-induced cancer cell invasion requires FAK phosphorylation; RCP expression induces FAK activation which links β1 integrin with EGFR in a positive regulatory loop; curcumin inhibits RCP-induced invasion by blocking β1 integrin stabilization and consequently inhibiting FAK and EGFR activation. Ectopic expression, pharmacological inhibition, Western blotting, invasion assays Experimental & molecular medicine Medium 29700289
2022 Mutant p53 (DNA-contact mutants) enhances RCP transcription through gain-of-function binding to Sp1/Sp3 transcription factors, whereas wild-type p53 suppresses RCP transcription by decreasing Sp1/3 protein levels; Sp1, Sp3, and Stat3 are transcriptional activators of RCP. Mass spectrometry, ChIP, reporter assays, knockdown/overexpression, mutant p53 expression Oncogene Medium 35256783
2022 STAT3 is phosphorylated downstream of the β1 integrin/EGFR axis in RCP-expressing cancer cells and drives invasion through the NF-κB/Slug/MT1-MMP signaling cascade; pharmacological or genetic inhibition of STAT3 blocks RCP-induced invasion. siRNA knockdown, pharmacological inhibition, Western blotting, invasion assays, immunohistochemistry Archives of pharmacal research Medium 35809175
2025 RCP brings RAB14 and MET together onto endosomal subdomains to facilitate RAB14-dependent tubulovesicular recycling of the MET receptor to invadopodia; KIF16B, a molecular motor recruited via RAB14, promotes endosomal tubulation required for MET recycling. Co-IP, proximity ligation assay, knockdown, live-cell imaging, invasion assays bioRxivpreprint Low bio_10.1101_2025.09.23.677683
2024 KIF3AC kinesin and RCP are required for focal adhesion reformation after disassembly in fibroblasts; KIF3C associates with β1 integrin in an RCP-dependent manner after FA disassembly, and KIF3AC knockdown inhibits trafficking of RCP toward the leading edge and polarized FA formation. Biochemical pulldown, knockdown, live-cell imaging, FA reformation assays bioRxivpreprint Low bio_10.1101_2024.12.09.627580

Source papers

Stage 0 corpus · 88 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. The Journal of biological chemistry 255 10903324
2002 Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. The Journal of biological chemistry 141 11786538
2013 RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. The Journal of cell biology 115 24019536
2009 RCP is a human breast cancer-promoting gene with Ras-activating function. The Journal of clinical investigation 110 19620787
2012 Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. The Journal of cell biology 109 22270919
2001 Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection. Infection and immunity 97 11401964
1979 Structural differences in reciprocal translocations. Potential for a model of risk in Rcp. Human genetics 82 511145
2004 The RCP-Rab11 complex regulates endocytic protein sorting. Molecular biology of the cell 75 15181150
1996 Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. Human molecular genetics 73 8733135
2002 The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. Biochemical and biophysical research communications 71 11944901
2001 The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. Peptides 61 11754963
2020 Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Cell reports 51 32640214
2012 Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling. Endocrinology 46 22315449
2011 FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells. Biomaterials 43 21605902
2002 Receptor component protein (RCP): a member of a multi-protein complex required for G-protein-coupled signal transduction. Biochemical Society transactions 41 12196115
2013 Role of CGRP-receptor component protein (RCP) in CLR/RAMP function. Current protein & peptide science 40 23745704
2010 FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Molecular biology of the cell 38 20610657
2003 An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. Molecular and cellular biology 38 12482973
2016 RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin. Oncogene 36 27524413
2013 Impacts of changes in climate and land use/land cover under IPCC RCP scenarios on streamflow in the Hoeya River Basin, Korea. The Science of the total environment 36 23506851
1978 Partial trisomy of the short arm of chromosome 7 due to a familial translocation rcp(7;14)(p11;p11). Clinical genetics 36 699358
1975 Trisomy iop. A report of two cases due to a familial translocation rcp (10;21) (pII;pII). Annales de genetique 33 1080038
2020 Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol. Experimental & molecular medicine 32 32728068
2006 The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Biochimica et biophysica acta 30 16920206
1997 Prospects of riboflavin carrier protein (RCP) as an antifertility vaccine in male and female mammals. Human reproduction update 27 9459278
2018 RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin. Experimental & molecular medicine 26 29700289
2009 Biochemical characterization of riboflavin carrier protein (RCP) in prostate cancer. Frontiers in bioscience (Landmark edition) 25 19273299
2019 Rab25 and RCP in cancer progression. Archives of pharmacal research 23 30761451
2000 Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP). Investigative ophthalmology & visual science 23 10752955
2008 Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP). The Journal of biological chemistry 22 18990693
2021 Rab11-FIP1 mediates epithelial-mesenchymal transition and invasion in esophageal cancer. EMBO reports 21 33403789
2019 In vitro and in vivo effects of insulin-producing cells generated by xeno-antigen free 3D culture with RCP piece. Scientific reports 21 31341242
2010 A new fluorescent imaging of renal inflammation with RCP. Journal of controlled release : official journal of the Controlled Release Society 21 20849894
1981 Two familial cases with trisomy 15q dist due to a rcp(5;15)(p14;q21). Human genetics 21 7195379
2021 Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. Cell death & disease 20 33627632
2004 Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. FEBS letters 20 15280022
2015 Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP). The Journal of biological chemistry 19 26032412
2008 Characterization of a balanced reciprocal translocation, rcp(9;11)(q27;q11) in cattle. Cytogenetic and genome research 19 18253034
2010 Is Rab25 a tumor promoter or suppressor--context dependency on RCP status? Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 17 20376596
2019 Comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (PiCV rCP) in pigeons uninfected and subclinically infected with PiCV. PloS one 14 31251772
1992 Stillborns, partially monosomic and partially trisomic, in the offspring of a boar carrying a translocation: rcp(14;15)(q29;q24). Hereditas 14 1399704
2023 Immunogenicity and Safety of a Combined Intramuscular/Intranasal Recombinant Spike Protein COVID-19 Vaccine (RCP) in Healthy Adults Aged 18 to 55 Years Old: A Randomized, Double-Blind, Placebo-Controlled, Phase I Trial. Vaccines 13 36851334
2023 Phase II, Safety and Immunogenicity of RAZI Cov Pars (RCP) SARS Cov-2 Vaccine in Adults Aged 18-70 Years; A Randomized, Double-Blind Clinical Trial. Journal of pharmaceutical sciences 12 37832918
2017 Rab11-FIP1 phosphorylation by MARK2 regulates polarity in MDCK cells. Cellular logistics 12 28396819
1995 Reciprocal chromosome translocation, rcp(7;17)(q26;q11), in a boar giving reduced litter size and increased rate of piglets dying in the early life. Hereditas 12 8537241
1992 A reciprocal whole-arm translocation, rcp(1;6)(1p6p;1q6q) in a boar, localization of the breakpoints, and reassignment of the genes for glucose phosphate isomerase (GPI) and calcium release channel (CRC). Cytogenetics and cell genetics 12 1324140
2007 A new case of reciprocal translocation in a young bull: rcp(11;21)(q28;q12). Cytogenetic and genome research 11 17268182
1993 Synaptonemal complex analysis of a reciprocal translocation, rcp(20;24) (q17;q25), in a subfertile bull. Cytogenetics and cell genetics 11 8428510
1990 Partial trisomy of chromosome 18 (pter----q12) following a familial 18;21 translocation rcp(18;21)(q12;q11). Human heredity 11 2335369
1996 Antigenic determinants at the carboxy terminus of chicken egg white riboflavin carrier protein (RCP): epitope mapping and antibody-mediated pregnancy curtailment in rodents. Vaccine 10 8744558
1994 Stability of YACs containing ribosomal or RCP/GCP locus DNA in wild-type S. cerevisiae and RAD mutant strains. DNA research : an international journal for rapid publication of reports on genes and genomes 10 8535977
2022 Integrated assessment of localized SSP-RCP narratives for climate change adaptation in coupled human-water systems. The Science of the total environment 9 35124036
2022 TP53 mutations upregulate RCP expression via Sp1/3 to drive lung cancer progression. Oncogene 9 35256783
2021 Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination. International journal of molecular sciences 9 34638806
2008 Structure of recombinant capsids formed by the beta-annulus deletion mutant -- rCP (Delta48-59) of Sesbania mosaic virus. Virology 9 18295296
2005 Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium. Journal of molecular endocrinology 9 16216915
2022 STAT3 mediates RCP-induced cancer cell invasion through the NF-κB/Slug/MT1-MMP signaling cascade. Archives of pharmacal research 8 35809175
1990 Anophthalmia in a retarded girl with partial trisomy 4p and 22 following a maternal translocation, rcp(4;22)(p15.2;q11.2). Ophthalmic paediatrics and genetics 8 2377354
2024 A New Proposal for Adequate Resection Margins in Larynx and Hypopharynx Tumor Surgery-Are the RCP Guidelines Feasible? Cancers 7 38893176
2022 Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage. American journal of physiology. Gastrointestinal and liver physiology 7 35819177
1996 Comparative amplification analysis of human glioma tissue and glioma derived fragment spheroids using reverse chromosome painting (RCP). Anticancer research 7 8917357
2017 Comparative efficacy of the Leucofeligen™ FeLV/RCP and Purevax™ RCP FeLV vaccines against infection with circulating feline Calicivirus. BMC veterinary research 6 29017551
2008 Extensive nonhomologous meiotic synapsis between normal chromosome axes of an rcp(3;6)(p14;q21) translocation in a hairless Mexican boar. Cytogenetic and genome research 6 18467833
2024 Immunogenicity and safety of RAZI recombinant spike protein vaccine (RCP) as a booster dose after priming with BBIBP-CorV: a parallel two groups, randomized, double blind trial. BMC medicine 5 38378570
2024 Climate and land use changes impact the trajectories of ecosystem service bundles in an urban agglomeration: Intricate interaction trends and driver identification under SSP-RCP scenarios. The Science of the total environment 5 38857801
2024 Projecting LUCC dynamics and ecosystem services in an emerging urban agglomeration under SSP-RCP scenarios and their management implications. The Science of the total environment 5 39084394
2011 A new and unusual reciprocal translocation in cattle: rcp(11;25)(q11;q14-21). Cytogenetic and genome research 5 21389692
1996 Variable expression of phenotype in offspring with partial monosomy 7q and partial trisomy 8p in a family with a rcp (7;8)(134;p12) translocation. Genetic counseling (Geneva, Switzerland) 5 8985736
2024 Safety and efficacy of RCP recombinant spike protein covid-19 vaccine compared to Sinopharm BBIBP: A phase III, non-inferiority trial. Heliyon 4 38463808
2022 Cropland nitrous oxide emissions exceed the emissions of RCP 2.6: A global spatial analysis. The Science of the total environment 4 36334657
2007 Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. American journal of perinatology 4 17853344
2025 High-resolution global distribution projections of 10 rodent genera under diverse SSP-RCP scenarios, 2021-2100. Scientific data 3 40846874
1995 Synaptonemal complex analysis in a boar with tertiary, trisomy, product of a rcp(7;17)(q26;q11) translocation. Hereditas 3 8537242
2025 Carbon Storage Response to Land Use/Land Cover Changes and SSP-RCP Scenarios Simulation: A Case Study in Yunnan Province, China. Ecology and evolution 2 39790722
2021 Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer. Frontiers in oncology 2 35757381
2018 Involvement of CGRP-RCP in the caveolin-1/ERK1/2 signal pathway in the static pressure-induced proliferation of vascular smooth muscle cells. Journal of cellular physiology 2 29741760
2014 A new case of an inherited reciprocal translocation in cattle: rcp(13;26) (q24;q11). Cytogenetic and genome research 2 25401777
1989 Familial mental retardation associated with balanced chromosome rearrangement rcp t(8;11)(q24.3;p15.1). Journal of medical genetics 2 2585460
2025 Assessment of ecological risk under different SSP-RCP scenarios of the Xinjiang province in China. Scientific reports 1 40069224
2023 microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane. Apoptosis : an international journal on programmed cell death 1 37945815
2019 Data set on current and future crop suitability under the Representative Concentration Pathway (RCP) 8.5 emission scenario for the major crops in the Levant, Tigris-Euphrates, and Nile Basins. Data in brief 1 30740483
2026 Age-related lncRNA alterations of SDHAP2_miR-17-5p/miR-20b-5p_RAB11FIP1 ceRNA network in donor-derived human limbal epithelial cells. Frontiers in cell and developmental biology 0 41983190
2024 Loss of Calcitonin Gene Related Receptor component protein (RCP) in nervous system can bias "gepant" antagonism. bioRxiv : the preprint server for biology 0 39484482
2020 Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation. Cellular signalling 0 32860953
2019 Correction: RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin. Oncogene 0 30679788
2019 Investigation of Intense Precipitation from Tropical Cyclones during the 21st Century by Dynamical Downscaling of CCSM4 RCP 4.5. International journal of environmental research and public health 0 30813587
2004 Immunocontraceptive potential of recombinantly expressed minimized chicken riboflavin carrier protein (mini-RCP) in rodents. Indian journal of biochemistry & biophysics 0 22900355
1992 BglII RFLP in DXS 498 between the pigment gene repeat unit, RCP and GCP. Human genetics 0 1362560