Affinage

PSMD6

26S proteasome non-ATPase regulatory subunit 6 · UniProt Q15008

Round 2 corrected
Length
389 aa
Mass
45.5 kDa
Annotated
2026-04-28
130 papers in source corpus 3 papers cited in narrative 3 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PSMD6 (p44S10/Rpn7) is a non-ATPase lid subunit of the 19S regulatory particle of the 26S proteasome, essential for correct lid subcomplex assembly and holoenzyme structural integrity; loss-of-function mutations cause accumulation of polyubiquitinated proteins and failure to degrade N-end rule, UFD pathway, and cell cycle regulatory substrates (PMID:15102831). Beyond canonical proteasomal function, PSMD6 translocates to the nucleus upon genotoxic stress, where it colocalizes with and stabilizes long-lived DNA damage foci, promoting cellular senescence (PMID:22473755). Overexpression of PSMD6 is sufficient to drive cell proliferation in melanoma cells, and its copy number and expression are increased in cutaneous malignant melanoma (PMID:10723133).

Mechanistic history

Synthesis pass · year-by-year structured walk · 3 steps
  1. 2000 Medium

    Identifying PSMD6 as a 26S proteasome subunit whose overexpression is sufficient to drive tumor cell proliferation established a functional link between this regulatory particle component and oncogenic growth.

    Evidence Expression cloning from transformed cells, copy number analysis, and in vivo overexpression-driven proliferation assay in melanoma cells

    PMID:10723133

    Open questions at the time
    • Gain-of-function result from a single lab without independent replication
    • Mechanism by which PSMD6 overexpression promotes proliferation (proteasome-dependent or independent) was not determined
    • Whether the proliferative effect is specific to PSMD6 or generalizable to other 19S subunits is unknown
  2. 2004 High

    Demonstrating that Rpn7 is required for proper lid assembly and 26S holoenzyme integrity resolved how this subunit contributes to proteasomal function: it scaffolds at least three other lid components, and its loss broadly impairs ubiquitin-dependent proteolysis.

    Evidence Temperature-sensitive yeast mutants, affinity purification of proteasome subcomplexes, and degradation assays for multiple UPS substrates (N-end rule, UFD, Pds1, Clb2)

    PMID:15102831

    Open questions at the time
    • Whether human PSMD6 performs an identical scaffolding role in mammalian lid assembly has not been directly tested
    • No structural model of Rpn7 contacts within the lid was provided
    • Whether the assembly defect is primary or secondary to Rpn7 misfolding was not resolved
  3. 2012 Medium

    Revealing that PSMD6 translocates to the nucleus upon DNA damage and stabilizes long-lived DNA damage foci uncovered a proteasome-independent role in the DNA damage response and cellular senescence.

    Evidence siRNA knockdown, γH2AX colocalization by immunofluorescence, nuclear fractionation, and foci lifespan quantification in human cells

    PMID:22473755

    Open questions at the time
    • Single-lab study; independent confirmation in other cell systems is lacking
    • The molecular mechanism by which PSMD6 protects foci from resolution (e.g., direct protein interactions at foci) is unknown
    • Whether this nuclear DDR role requires intact proteasome or is proteasome-independent was not distinguished

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how PSMD6's structural role in lid assembly, its DDR foci-stabilizing function, and its proliferation-promoting activity upon overexpression are mechanistically integrated, and whether these reflect proteasome-dependent or proteasome-independent activities.
  • No direct biochemical characterization of PSMD6 molecular activity beyond scaffolding
  • No structure of human PSMD6 within the 19S lid at sufficient resolution to identify interaction surfaces
  • Relationship between PSMD6 dosage, proteasome activity, DDR stabilization, and proliferation has not been dissected

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 1
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-392499 Metabolism of proteins 1 R-HSA-73894 DNA Repair 1
Complex memberships
26S proteasome (19S regulatory particle lid)

Evidence

Reading pass · 3 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Rpn7 (the yeast ortholog of PSMD6) is required for the structural integrity of the 26S proteasome. Temperature-sensitive rpn7 mutants accumulate poly-ubiquitinated proteins and fail to degrade N-end rule substrates, UFD pathway substrates, and cell cycle regulators (Pds1 and Clb2). Analysis of the proteasome in rpn7-3 mutant cells revealed a defect in 26S holoenzyme assembly; the lid subcomplex purified from rpn7-3 cells contained only 5 of the 8 lid components, indicating Rpn7 is essential for establishing correct lid structure. Temperature-sensitive mutant analysis, affinity purification of 26S proteasome subcomplexes, ubiquitin-proteasome pathway substrate degradation assays The Journal of biological chemistry High 15102831
2000 The p44S10 gene (PSMD6), located on human chromosome 3p14.1, encodes a highly conserved subunit of the 26S proteasome regulatory particle. p44S10 gene copy number and mRNA expression were increased in cutaneous malignant melanoma cell lines and tumors. Importantly, increased expression of p44S10 was sufficient to induce proliferation of radial growth phase WM35 melanoma cells in vivo, establishing a functional role for PSMD6 overexpression in promoting cell proliferation. Expression cloning from morphologically transformed cells, chromosomal copy number analysis, overexpression-driven in vivo proliferation assay Oncogene Medium 10723133
2012 The 19S proteasome subunit Rpn7 (human PSMD6) translocates to the nucleus and colocalizes with DNA damage foci over their entire lifespan following genotoxic insult. Silencing of Rpn7 promotes faster resolution of DNA damage foci and specifically decreases the frequency of long-lived DNA damage foci without affecting the repair rate of short-lived foci, indicating that Rpn7 interaction with DDR foci in situ protects them from premature resolution and thereby enables cellular senescence. siRNA knockdown, immunofluorescence colocalization with DNA damage foci (γH2AX), nuclear fractionation, foci lifespan quantification IUBMB life Medium 22473755

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Biological insights from 108 schizophrenia-associated genetic loci. Nature 5878 25056061
2002 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 1924 12167863
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annual review of biochemistry 1398 19489727
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2003 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 1236 12808466
2003 DNA deamination mediates innate immunity to retroviral infection. Cell 1150 12809610
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2003 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science (New York, N.Y.) 1006 14564014
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2003 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature 912 12808465
2013 Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature 870 23503661
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2004 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nature cell biology 841 14743216
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Nature medicine 798 14528300
2008 Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 787 18854154
2003 Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell 763 12859895
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2003 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Nature medicine 679 14528301
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2003 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Molecular cell 607 14527406
2003 Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science (New York, N.Y.) 570 12750511
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2011 Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nature genetics 495 22158537
1997 Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proceedings of the National Academy of Sciences of the United States of America 248 9391153
2013 R loops are linked to histone H3 S10 phosphorylation and chromatin condensation. Molecular cell 229 24211264
1993 Recognition of boxA antiterminator RNA by the E. coli antitermination factors NusB and ribosomal protein S10. Cell 133 7678781
1991 Assembly of transcription elongation complexes containing the N protein of phage lambda and the Escherichia coli elongation factors NusA, NusB, NusG, and S10. Genes & development 126 1831176
1981 Evidence that ribosomal protein S10 participates in control of transcription termination. Proceedings of the National Academy of Sciences of the United States of America 125 6453343
2010 Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. The Journal of biological chemistry 119 20159986
1985 Structure of the Escherichia coli S10 ribosomal protein operon. Nucleic acids research 111 3892488
2013 Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance. Antimicrobial agents and chemotherapy 108 24379204
2015 The ribosomal S10 protein is a general target for decreased tigecycline susceptibility. Antimicrobial agents and chemotherapy 105 26124155
2002 The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. The Journal of biological chemistry 103 11925449
1998 Detection and assignment of proteins encoded by rice black streaked dwarf fijivirus S7, S8, S9 and S10. The Journal of general virology 102 9634092
2008 Conservation of the S10-spc-alpha locus within otherwise highly plastic genomes provides phylogenetic insight into the genus Leptospira. PloS one 93 18648538
1982 The structure of the gene coding for the phosphorylated ribosomal protein S10 in yeast. Nucleic acids research 92 6292856
2005 MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. Journal of cell science 88 15870105
2005 High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants. Antimicrobial agents and chemotherapy 86 16189114
2008 Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex. Molecular cell 83 19111659
1983 Transcription of the S10 ribosomal protein operon is regulated by an attenuator in the leader. Cell 80 6380754
1986 Genes for the eight ribosomal proteins are clustered on the chloroplast genome of tobacco (Nicotiana tabacum): similarity to the S10 and spc operons of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 73 3016736
1995 Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. Biochimica et biophysica acta 66 7772601
1992 Multiple glycoproteins synthesized by the smallest RNA segment (S10) of bluetongue virus. Journal of virology 66 1331513
1992 Direct interaction between two Escherichia coli transcription antitermination factors, NusB and ribosomal protein S10. Journal of molecular biology 66 1731086
1975 Nucleotide sequences of Escherichia coli 16-S RNA associated with ribosomal proteins S7, S9, S10, S14 and S19. European journal of biochemistry 64 1100389
1999 Sequence comparison of the L2 and S10 genes of bluetongue viruses from the United States and the People's Republic of China. Virus research 61 10475085
1987 Autogenous control of the S10 ribosomal protein operon of Escherichia coli: genetic dissection of transcriptional and posttranscriptional regulation. Proceedings of the National Academy of Sciences of the United States of America 60 2442760
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. The Journal of biological chemistry 60 925037
1987 RNA-protein cross-linking in Escherichia coli 30S ribosomal subunits; determination of sites on 16S RNA that are cross-linked to proteins S3, S4, S7, S9, S10, S11, S17, S18 and S21 by treatment with bis-(2-chloroethyl)-methylamine. Nucleic acids research 54 2437528
2005 Assembly of an RNA-protein complex. Binding of NusB and NusE (S10) proteins to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli. The Journal of biological chemistry 53 16109710
1988 Probing the assembly of the 3' major domain of 16 S rRNA. Interactions involving ribosomal proteins S2, S3, S10, S13 and S14. Journal of molecular biology 53 2459390
2006 Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATX-s10 (Na). International journal of oncology 47 16820876
1981 Regulation of the S10 ribosomal protein operon in E. coli: nucleotide sequence at the start of the operon. Cell 47 7037196
2023 Efficacy and safety of Oleogel-S10 (birch triterpenes) for epidermolysis bullosa: results from the phase III randomized double-blind phase of the EASE study. The British journal of dermatology 46 36689495
2004 Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae. The Journal of biological chemistry 45 15102831
1997 Analysis of the Bacillus subtilis S10 ribosomal protein gene cluster identifies two promoters that may be responsible for transcription of the entire 15-kilobase S10-spc-alpha cluster. Journal of bacteriology 41 9371452
1990 Escherichia coli ribosomal protein L4 stimulates transcription termination at a specific site in the leader of the S10 operon independent of L4-mediated inhibition of translation. Journal of molecular biology 41 1692593
2005 Organisation of the S10, spc and alpha ribosomal protein gene clusters in prokaryotic genomes. FEMS microbiology letters 40 15621428
2000 Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. The EMBO journal 39 10698923
1990 Ribosomal protein L4 stimulates in vitro termination of transcription at a NusA-dependent terminator in the S10 operon leader. Proceedings of the National Academy of Sciences of the United States of America 39 2157208
2003 Necrotic and apoptotic cell death of human malignant melanoma cells following photodynamic therapy using an amphiphilic photosensitizer, ATX-S10(Na). Lasers in surgery and medicine 38 12866123
1999 Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. The Journal of biological chemistry 38 9915854
1998 Phylogenetic analysis of the S10 gene of field and laboratory strains of bluetongue virus from the United States. Virus research 38 9712508
2011 Classification of the genus Bacillus based on MALDI-TOF MS analysis of ribosomal proteins coded in S10 and spc operons. Journal of agricultural and food chemistry 37 21469741
1989 The primary structure of rat ribosomal protein S10. European journal of biochemistry 36 2543570
1989 Antiribosomal S10 antibodies in humans and MRL/lpr mice with systemic lupus erythematosus. Arthritis and rheumatism 35 2478135
2006 Functional study of hot pepper 26S proteasome subunit RPN7 induced by Tobacco mosaic virus from nuclear proteome analysis. Biochemical and biophysical research communications 34 17070775
1985 Yeast contains two functional genes coding for ribosomal protein S10. Nucleic acids research 33 2991849
1999 Phylogenetic analysis of L4-mediated autogenous control of the S10 ribosomal protein operon. Journal of bacteriology 32 10498727
1990 The cyanelle S10 spc ribosomal protein gene operon from Cyanophora paradoxa. Molecular & general genetics : MGG 32 2126059
1985 Evidence that ribosomal protein S10 itself is a cellular component necessary for transcription antitermination by phage lambda N protein. Proceedings of the National Academy of Sciences of the United States of America 32 2987961
2003 RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operon. The Journal of biological chemistry 31 12738792
1989 Cotranscription of the S10- and spc-like operons in spinach chloroplasts and identification of three of their gene products. Molecular & general genetics : MGG 31 2747623
1988 Secondary structure of the leader transcript from the Escherichia coli S10 ribosomal protein operon. Nucleic acids research 31 3050893
2014 An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation. Molecular biology of the cell 30 24430871
2010 Classification of genus Pseudomonas by MALDI-TOF MS based on ribosomal protein coding in S10-spc-alpha operon at strain level. Journal of proteome research 30 20945934
2018 Characterization and high-efficiency secreted expression in Bacillus subtilis of a thermo-alkaline β-mannanase from an alkaliphilic Bacillus clausii strain S10. Microbial cell factories 29 30098601
1988 Nucleotide sequence of segment S10 of the rice dwarf virus genome. The Journal of general virology 29 3335833
2000 In vitro plasma protein binding and cellular uptake of ATX-S10(Na), a hydrophilic chlorin photosensitizer. Japanese journal of cancer research : Gann 28 10965027
1996 A hairpin structure upstream of the terminator hairpin required for ribosomal protein L4-mediated attenuation control of the S10 operon of Escherichia coli. Journal of bacteriology 28 8636042
1995 The gene for ribosomal protein S10 is present in mitochondria of pea and potato but absent from those of Arabidopsis and Oenothera. Current genetics 28 7553942
1985 Genetic dissection of stringent control and nutritional shift-up response of the Escherichia coli S10 ribosomal protein operon. Journal of molecular biology 28 2414454
2011 Molecular characterization of segments S7 to S10 of a southern rice black-streaked dwarf virus isolate from maize in northern China. Virologica Sinica 27 21331890
2008 Molecular epidemiology of the African horse sickness virus S10 gene. The Journal of general virology 27 18420793
2008 Transcription by moonlight: structural basis of an extraribosomal activity of ribosomal protein S10. Molecular cell 27 19111651
1992 Ribosomal protein L4 and transcription factor NusA have separable roles in mediating terminating of transcription within the leader of the S10 operon of Escherichia coli. Genes & development 27 1285127
2014 Discrimination of Escherichia coli O157, O26 and O111 from other serovars by MALDI-TOF MS based on the S10-GERMS method. PloS one 26 25411793
2012 Characterization of the Lactobacillus casei group based on the profiling of ribosomal proteins coded in S10-spc-alpha operons as observed by MALDI-TOF MS. Systematic and applied microbiology 26 23099260
2003 Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26. Protein expression and purification 26 12651107
2000 The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. Oncogene 26 10723133
2020 Antagonistic action of Streptomyces pratensis S10 on Fusarium graminearum and its complete genome sequence. Environmental microbiology 25 33073508
2001 Complete nucleotide sequence of the S10 genome segment of grass carp reovirus (GCRV). Diseases of aquatic organisms 25 11253877
2000 Photodynamic therapy for experimental tumors using ATX-S10(Na), a hydrophilic chlorin photosensitizer, and diode laser. Japanese journal of cancer research : Gann 24 10920284
1995 Role of NusA in L4-mediated attenuation control of the S10 r-protein operon of Escherichia coli. Journal of molecular biology 24 7844821
1991 Nucleotide sequences of genome segments S8, encoding a capsid protein, and S10, encoding a 36K protein, of rice gall dwarf virus. The Journal of general virology 24 1940872
2018 Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15S1-CD163 and PK15S10-CD163 cells. Veterinary research 23 30021620
2017 Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors. ACS medicinal chemistry letters 23 29057042
1990 Nucleotide sequence of four genes encoding ribosomal proteins from the 'S10 and spectinomycin' operon equivalent region in the archaebacterium Halobacterium marismortui. FEBS letters 23 2143141
1989 Translational coupling of the two proximal genes in the S10 ribosomal protein operon of Escherichia coli. Journal of bacteriology 23 2651412
2018 Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model. Investigational new drugs 22 30073464
1990 Transcriptional organization of the S10, spc and alpha operons of Escherichia coli. Biochimica et biophysica acta 22 2207163
2019 Deficiency of mitoribosomal S10 protein affects translation and splicing in Arabidopsis mitochondria. Nucleic acids research 21 31732734
1990 Nucleotide sequences of Bacillus stearothermophilus ribosomal protein genes: part of the ribosomal S10 operon. Biological chemistry Hoppe-Seyler 20 2222862
2019 Oleogel-S10 Phase 3 study "EASE" for epidermolysis bullosa: study design and rationale. Trials 19 31186047
2014 Insect midgut carboxypeptidases with emphasis on S10 hemipteran and M14 lepidopteran carboxypeptidases. Insect molecular biology 19 25488368
1997 Rice ragged stunt oryzavirus genome segments S7 and S10 encode non-structural proteins of M(r) 68,025 (Pns7) and M(r) 32,364 (Pns10). Archives of virology 19 9672632
1995 RNA determinants required for L4-mediated attenuation control of the S10 r-protein operon of Escherichia coli. Journal of molecular biology 19 7531246
2013 Novel accurate bacterial discrimination by MALDI-time-of-flight MS based on ribosomal proteins coding in S10-spc-alpha operon at strain level S10-GERMS. Journal of the American Society for Mass Spectrometry 18 23686278
2003 Activation of two caspase cascades, caspase 8/3/6 and caspase 9/3/6, during photodynamic therapy using a novel photosensitizer, ATX-S10(Na), in normal human keratinocytes. Archives of dermatological research 18 13680269
1988 Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin. FEBS letters 18 3378620
1985 Transcriptional control of the S10 ribosomal protein operon of Escherichia coli after a shift to higher temperature. Journal of bacteriology 18 3891722
1982 Crosslinking of N-acetyl-phenylalanyl [s4U]tRNAPhe to protein S10 in the ribosomal P site. European journal of biochemistry 18 6759118
2000 Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt. Biochimica et biophysica acta 17 11121577
1984 Role of attenuation in growth rate-dependent regulation of the S10 r-protein operon of E. coli. The EMBO journal 17 6378627
2012 The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB life 16 22473755
2005 Sequence analysis of genome segments S5 and S10 of Mal de Rio Cuarto virus (Fijivirus, Reoviridae). Archives of virology 16 15747051
1994 A ribosomal protein S10 gene is found in the mitochondrial genome in Solanum tuberosum. Plant molecular biology 16 8061325
1994 Cloning of the Nilaparvata lugens reovirus genome: conserved terminal nucleotide sequences and nucleotide sequence of genome segment S10. The Journal of general virology 16 8113731
1997 Nucleotide sequence comparison of the segments S10 of the nine African horsesickness virus serotypes. Archives of virology 15 9191861
1994 Phylogenetic depth of S10 and spc operons: cloning and sequencing of a ribosomal protein gene cluster from the extremely thermophilic bacterium Thermotoga maritima. Journal of bacteriology 15 8002596
2017 Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline. Antimicrobial agents and chemotherapy 14 29084741
2005 Adaptations required for mitochondrial import following mitochondrial to nucleus gene transfer of ribosomal protein S10. Plant physiology 14 16040655
2005 Novel transdermal photodynamic therapy using ATX-S10.Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice. Rheumatology international 14 16220291