cAMP-dependent protein kinase type II-alpha regulatory subunit · UniProt P13861
PRKAR2A encodes the type IIα regulatory subunit (RIIα) of cAMP-dependent protein kinase A (PKA), functioning as a cAMP-responsive inhibitory subunit that suppresses PKA catalytic activity and spatially organizes PKA holoenzymes through A-kinase anchoring proteins (AKAPs) (PMID:24501172, PMID:22674394, PMID:23426434). RIIα physically binds AKAP1 to enforce cytoplasmic anchoring of PKA, and its translocation with PKA-C from cytoplasm to nucleus precedes meiotic resumption in oocytes, establishing RIIα as a determinant of PKA compartmentalization (PMID:24501172, PMID:22674394, PMID:23426434); an analogous role in neurons directs dendritic localization of PKA catalytic subunits in medial habenula neurons, where loss of Prkar2a reduces local PKA activity and alters feeding and exercise behaviors that are rescued by habenular re-expression (PMID:33141766). Because RIIα restrains catalytic activity, its loss produces unrestrained cAMP/PKA signaling: Prkar2a-deficient mice develop histiocytic sarcomas, and reduction of PKA type II activity by Prkar2a haploinsufficiency rescues the dysplastic bone phenotype of Prkar1a heterozygotes (PMID:26608815, PMID:26246497). In liver, a high PRKACA/PRKAR2A ratio activates PKA and confers fibrolamellar-like features, and combined BAP1 and PRKAR2A loss drives hepatocyte transdifferentiation into ductal/progenitor-like cells, with PRKAR2A loss specifically required to overcome cell-cycle arrest (PMID:31862487, PMID:37137901). Beyond PKA regulation, RIIα directly binds the IFN-γ receptor transmembrane domain downstream of DP1 activation to suppress JAK2/STAT1-driven M1 macrophage polarization and promote inflammatory resolution (PMID:27621415), and the PRKAR2A promoter is transcriptionally repressed by HDAC1/2–Sp1/Sp3–RbAp48 complexes at GC-rich domains (PMID:19818097).
Establishing the chromosomal location of PRKAR2A provided the genomic anchor later used to interpret copy-number changes affecting the RIIα subunit.
Evidence somatic cell hybrid and radiation hybrid PCR mapping
Surveying PKA subunit levels in cortisol-secreting adenomas tied altered regulatory-subunit abundance to elevated basal PKA activity, framing PKA dysregulation in endocrine tumors.
Evidence Western blot, RT-qPCR, PKA activity and mutation analysis in primary human adrenocortical tumors
Defined how PRKAR2A expression itself is controlled, showing its GC-rich promoter is repressed by HDAC1/2–Sp1/Sp3 complexes and derepressed by HDAC inhibition.
Evidence ChIP, luciferase reporter assays, and trichostatin A treatment in human myometrial smooth muscle cells
Identified a direct physical partner for RIIα, establishing AKAP1 as the major AKAP binding PRKAR2A and the molecular basis for PKA anchoring in oocytes.
Evidence Far-Western blot with purified PRKAR2A probe plus AKAP1 overexpression/knockdown in porcine oocytes
Demonstrated that RIIα controls PKA activity and localization dynamically during meiotic resumption, with AKAP-mediated cytoplasmic anchoring maintaining arrest and nuclear translocation accompanying resumption.
Evidence antisense knockdown, AKAP-binding inhibition peptides, overexpression, PKA activity assays and immunofluorescence in porcine oocytes
Showed that RIIα-mediated suppression of PKA activity modulates chemotherapy sensitivity, linking the subunit's inhibitory function to cell survival.
Evidence promoter-insertion mutagenesis screen, overexpression of full-length/truncated constructs, PKA activity and PKI inhibitor assays in prostate cancer cells
Genetic loss-of-function in mice established PRKAR2A as a tumor-relevant suppressor whose loss specifically predisposes to histiocytic sarcomas.
Evidence Prkar2a knockout mouse cohort with IHC, Southern blot clonality, and cross-genotype comparison
Genetic epistasis showed that lowering PKA type II activity via Prkar2a haploinsufficiency rescues the Prkar1a-mutant bone phenotype, confirming RIIα contributes to total PKA type II output in vivo.
Evidence double-heterozygote mice with bone histology, mineralization markers, and PKA activity assays
Revealed a PKA-independent signaling role: RIIα binds the IFN-γ receptor transmembrane domain downstream of DP1 to suppress JAK2/STAT1 and bias macrophages toward M2 resolution.
Evidence Co-IP of PRKAR2A with IFN-γ receptor, DP1 and PRKAR2A genetic deletion across inflammatory models
Connected PRKAR2A loss to human liver cancer, showing a high PRKACA/PRKAR2A ratio activates PKA and confers fibrolamellar-like features.
Evidence RNAseq, WGS/WES of 151 liver tumors with Western blot and TCGA validation
Functional reconstitution established that PRKAR2A loss is causally required, alongside BAP1 loss, to overcome cell-cycle arrest and drive hepatocyte transdifferentiation into ductal/progenitor-like cells.
Evidence CRISPR-engineered human hepatocyte organoids (BAP1, PRKAR2A, double KO) with phenotypic and primary-tumor comparison
Demonstrated a neuronal compartmentalization role, with RIIα required for dendritic PKA catalytic-subunit localization in medial habenula and for feeding/exercise behaviors.
Evidence Prkar2a knockout mice with PKA activity assays, dendritic localization imaging, viral rescue, and behavioral readouts
A PRKAR2A-ALK fusion in epithelioid fibrous histiocytoma implicated RIIα's Golgi-predominant localization in directing the fusion oncoprotein's subcellular pattern.
Evidence FISH, whole transcriptome sequencing, and ALK IHC in a single tumor case
A disease-associated AKAP9 variant that weakens AKAP9–PRKAR2A binding extended the anchoring-partner repertoire and linked it to premature coronary artery disease.
Evidence whole-exome sequencing of a pedigree with Sanger validation and a variant binding assay
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2016 | PRKAR2A (PKA regulatory IIα subunit) directly binds the transmembrane domain of IFN-γ receptor upon DP1 (prostaglandin D2 receptor subtype 1) activation, suppressing JAK2/STAT1 axis-mediated M1 macrophage polarization and promoting M2 polarization and resolution of inflammation. PRKAR2A deficiency attenuated DP1-mediated M2 polarization and inflammatory resolution. | Co-immunoprecipitation (binding of PRKAR2A to IFN-γ receptor transmembrane domain), genetic deletion of DP1 and PRKAR2A in macrophages with inflammatory phenotype readouts (cytokine production, M1/M2 polarization markers), multiple inflammatory models including myocardial infarction | The Journal of experimental medicine | High | 27621415 |
| 2011 | The proximal promoter of the PRKAR2A gene contains three Sp1/Sp3-binding GC-rich domains that recruit HDAC1/2 and RbAp48 transcriptional repressor complexes. Inhibition of HDACs with trichostatin A increases PRKAR2A mRNA and protein levels in human myometrial smooth muscle cells, preceded by increased acetylated H3, Pol IIa, Sp3, and HDAC2 binding at the GC domains. RIIα expression is upregulated during pregnancy and decreases at labor, correlating with particulate type II PKA activity. | ChIP assays (Sp1, Sp3, HDAC1/2, RbAp48 binding to promoter GC domains), luciferase reporter assays with full-length and truncated PRKAR2A promoter constructs, HDAC inhibitor (trichostatin A) treatment of primary human myometrial cells with mRNA/protein measurement | Journal of cellular and molecular medicine | High | 19818097 |
| 2014 | Overexpression of full-length or N-terminally truncated PRKAR2A markedly increased survival of prostate cancer cell lines treated with Taxol and Taxotere, with suppression of PKA enzymatic activity as the likely mechanism. The PKA inhibitor PKI (6-22) amide similarly reduced Taxol toxicity, supporting that PRKAR2A acts via PKA inhibition. | Random promoter-insertion mutagenesis screen in prostate cancer cells followed by high-throughput integration-site mapping; overexpression of full-length and truncated PRKAR2A constructs with cell viability assays; PKA activity measurement; pharmacological PKA inhibition with PKI (6-22) amide | Cell cycle (Georgetown, Tex.) | Medium | 25485509 |
| 2015 | Prkar2a-deficient (homozygous and heterozygous) mice frequently develop hematopoietic neoplasms dominated by histiocytic sarcomas, with rare diffuse large B-cell lymphomas confirmed as clonal B-cell neoplasms by Southern blot. Other PKA regulatory subunit-deficient genotypes did not develop similar neoplasms, indicating specificity to Prkar2a loss. | Mouse cohort study with Prkar2a(-/-) and Prkar2a(+/-) animals (ages 5–25 months); immunohistochemistry with tumor-specific markers; Southern blot for clonality; cell sorting and protein studies; comparison with other PKA subunit KO genotypes | Journal of experimental & clinical cancer research : CR | High | 26608815 |
| 2015 | Haploinsufficiency for Prkar2a (or Prkar2b) in Prkar1a(+/-) mice partially rescued the abnormal bone phenotype (fibrous dysplasia-like lesions, poor bone organization/mineralization), with increased osteogenesis and new bone formation rates, attributable to decreased PKA type II activity mediated by PRKAR2A and PRKAR2B subunits. | Generation of double heterozygote mice (Prkar1a(+/-)Prkar2a(+/-)); bone histology and mineralization markers; PKA activity assays in tissues; comparison with single heterozygotes and wild type | Human molecular genetics | High | 26246497 |
| 2020 | In the medial habenula (MHb), Prkar2a (RIIα) is required for proper dendritic localization of PKA catalytic subunits. Prkar2a knockout mice showed decreased habenular PKA enzymatic activity, impaired dendritic PKA catalytic subunit localization in MHb neurons, decreased consumption of palatable foods, and increased voluntary exercise motivation. Re-expression of Prkar2a specifically in the habenula rescued the PKA localization defect and behavioral phenotype. | Prkar2a knockout mice; PKA enzymatic activity assays in habenular tissue; immunofluorescence imaging of dendritic PKA catalytic subunit localization; viral re-expression of Prkar2a in habenula; behavioral assays (palatable food consumption, voluntary running wheel) | JCI insight | High | 33141766 |
| 2019 | In BAP1-mutant hepatocellular carcinoma (HCC), chromosome gain of PRKACA at 19p13 combined with loss of PRKAR2A (the inhibitory regulatory subunit of PKA) at 3p21 results in a high PRKACA/PRKAR2A ratio at mRNA and protein levels, leading to PKA pathway activation and conferring fibrolamellar-like features. | RNAseq and whole-genome/whole-exome sequencing of 151 liver tumors; Western blots validating protein-level PRKACA/PRKAR2A ratio; TCGA database validation | Journal of hepatology | Medium | 31862487 |
| 2023 | Combined loss of BAP1 and PRKAR2A in CRISPR-engineered human hepatocyte organoids caused hepatocyte transdifferentiation into liver ductal/progenitor-like cells that could exclusively grow in a ductal cell environment. BAP1 loss alone primed hepatocytes to proliferate in a cAMP-stimulating environment, but PRKAR2A loss was required to overcome cell cycle arrest and complete transdifferentiation. DNAJB1-PRKACA fusion alone produced milder phenotypes. | CRISPR engineering of human hepatocyte organoids with BAP1 KO, PRKAR2A KO, and double KO; phenotypic characterization (morphology, growth conditions, differentiation markers); comparison with primary FLC tumor samples; organoid growth assays in different media conditions | Nature communications | High | 37137901 |
| 2014 | In porcine oocytes, PRKAR2A can inhibit PKA activity and induce meiosis when overexpressed in cAMP-treated full-grown oocytes (FGOs). PKA-C and PRKAR2A (but not PRKAR1A) translocate from cytoplasm to nucleus just before meiotic resumption in FGOs. In contrast, overexpression of PRKAR2A did not affect PKA activity or meiotic resumption in growing oocytes (GOs). During meiotic arrest in FGOs, cytoplasmic anchoring by AKAPs acting through PRKAR2A (more than PRKAR1A) is required to maintain meiotic arrest. | Antisense RNA knockdown and AKAP-binding inhibition peptides for PRKAR1A and PRKAR2A in porcine oocytes; PKA activity assays; subcellular localization by immunofluorescence; meiotic resumption as functional readout; PRKAR2A overexpression in FGOs | Biology of reproduction | High | 22674394 24501172 |
| 2013 | Far-Western blot analysis using porcine PRKAR2A as a probe identified several novel AKAP signals in porcine oocytes, with AKAP1 (a 150-kDa band) as the major AKAP isoform. This directly demonstrated that PRKAR2A physically binds AKAP1 in oocytes, consistent with AKAP1-mediated PKA localization affecting meiotic resumption. | Far-Western blot using purified porcine PRKAR2A as probe on porcine oocyte lysates; identification of AKAP1 as the major binding partner; AKAP1 overexpression and knockdown with PKA localization and meiotic resumption readouts | Biology of reproduction | Medium | 23426434 |
| 1998 | The PRKAR2A gene (encoding the RIIα regulatory subunit of cAMP-dependent protein kinase) was mapped to human chromosome region 3p21.3-p21.2, with closest linkage to D3S3334. | PCR and Southern blot analysis of somatic cell hybrid mapping panels; Stanford G3 Radiation Hybrid Panel PCR mapping | Genomics | Medium | 9676433 |
| 2008 | A subgroup of cortisol-secreting adrenocortical adenomas (ACA-S2) showed a 96% reduction in PRKAR2B (R2B) protein compared to normal adrenal, without mutation of the R2B gene and without reduction of R2B mRNA, indicating a post-transcriptional loss mechanism. This loss of PRKAR2B correlated with a threefold higher basal PKA activity. Separately, R1A (PRKAR1A) mRNA was decreased in all ACA-S. PRKAR2A was assessed in this broader PKA subunit study context. | Western blot and RT-qPCR for PKA subunit proteins and mRNAs in 35 adrenocortical tumors; PKA activity measurement; mutation analysis of R2B gene | European journal of endocrinology | Medium | 18505904 |
| 2020 | A PRKAR2A-ALK fusion gene was identified in a case of epithelioid fibrous histiocytoma (EFH). The fusion produces a dot-like Golgi-pattern perinuclear ALK immunostaining, consistent with the known Golgi-predominant subcellular localization of PRKAR2A as the fusion partner directing ALK to this compartment. | FISH confirming ALK locus rearrangement; whole transcriptome sequencing identifying PRKAR2A-ALK fusion; ALK immunohistochemistry showing Golgi-pattern staining | The American Journal of dermatopathology | Medium | 32379091 |
| 2026 | A missense variant (c.6406C>G, p.Gln2136Glu) in AKAP9 decreased the physical interaction between AKAP9 and PRKAR2A, as shown by functional analysis in a premature coronary artery disease pedigree. | Whole-exome sequencing of family members; Sanger sequencing validation; functional interaction assay demonstrating decreased AKAP9-PRKAR2A binding for the variant | Molecular genetics & genomic medicine | Medium | 41574642 |
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2011 | Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. | The Journal of biological chemistry | 240 | 21296890 |
| 2014 | Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma. | Blood | 200 | 24914135 |
| 2013 | Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. | PloS one | 90 | 23874428 |
| 2015 | 'Conceptualizing' the Endometrium: Identification of Conceptus-Derived Proteins During Early Pregnancy in Cattle. | Biology of reproduction | 82 | 25947061 |
| 2018 | Circadian Rhythm of Glucocorticoid Administration Entrains Clock Genes in Immune Cells: A DREAM Trial Ancillary Study. | The Journal of clinical endocrinology and metabolism | 66 | 29846607 |
| 2016 | PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. | The Journal of experimental medicine | 62 | 27621415 |
| 2019 | BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA. | Journal of hepatology | 61 | 31862487 |
| 2021 | SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets. | Neoplasia (New York, N.Y.) | 58 | 33878706 |
| 2016 | Upregulated expression of BCL2, MCM7, and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer cell lines. | Investigative and clinical urology | 55 | 26966728 |
| 2018 | UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists | 50 | 29498920 |
| 2015 | A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration. | Endocrinology | 45 | 25396269 |
| 2020 | Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles. | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 35 | 32123303 |
| 2018 | ALK Gene Fusions in Epithelioid Fibrous Histiocytoma: A Study of 14 Cases, With New Histopathological Findings. | The American Journal of dermatopathology | 33 | 29329131 |
| 2014 | Age related changes of cAMP and MAPK signaling in Leydig cells of Wistar rats. | Experimental gerontology | 33 | 25019473 |
| 2021 | Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa. | Frontiers in cell and developmental biology | 32 | 34336820 |
| 2023 | Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss. | Nature communications | 27 | 37137901 |
| 2022 | LC-MS/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy. | Clinical proteomics | 24 | 36572849 |
| 2017 | Involvement of DPP9 in gene fusions in serous ovarian carcinoma. | BMC cancer | 23 | 28893231 |
| 2008 | Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity. | European journal of endocrinology | 22 | 18505904 |
| 2020 | Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations. | Thyroid : official journal of the American Thyroid Association | 21 | 32689909 |
| 2024 | Transcriptome and Metabolome Insights into Key Genes Regulating Fat Deposition and Meat Quality in Pig Breeds. | Animals : an open access journal from MDPI | 20 | 39765464 |
| 2019 | Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. | American journal of human genetics | 19 | 31178129 |
| 2022 | PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer. | Clinical and translational medicine | 18 | 35184406 |
| 2020 | TMT-based proteomics analysis to screen potential biomarkers of acute-phase TBI in rats. | Life sciences | 17 | 33131748 |
| 2016 | Integrated analysis identified an intestinal-like and a diffuse-like gene sets that predict gastric cancer outcome. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 17 | 27858295 |
| 2023 | Multiomic prioritisation of risk genes for anorexia nervosa. | Psychological medicine | 16 | 36803885 |
| 2022 | Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens). | Frontiers in physiology | 15 | 36277216 |
| 2016 | Aging has the opposite effect on cAMP and cGMP circadian variations in rat Leydig cells. | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology | 14 | 27915366 |
| 2022 | Molecular Signatures Correlated With Poor IVF Outcomes: Insights From the mRNA and lncRNA Expression of Endometriotic Granulosa Cells. | Frontiers in endocrinology | 12 | 35295989 |
| 2014 | Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment. | Cell cycle (Georgetown, Tex.) | 12 | 25485509 |
| 2013 | A-kinase anchor protein 1 (AKAP1) regulates cAMP-dependent protein kinase (PKA) localization and is involved in meiotic maturation of porcine oocytes. | Biology of reproduction | 12 | 23426434 |
| 2011 | Epigenetic modulation of the protein kinase A RIIα (PRKAR2A) gene by histone deacetylases 1 and 2 in human smooth muscle cells. | Journal of cellular and molecular medicine | 12 | 19818097 |
| 2021 | Oar-miR-16b and oar-miR-27a: negatively correlated with milk yield and milk protein in sheep. | Animal biotechnology | 11 | 33840373 |
| 2020 | Epithelioid Fibrous Histiocytoma With Dot-Like Perinuclear ALK Expression and PRKAR2A-ALK Fusion. | The American Journal of dermatopathology | 11 | 32379091 |
| 2018 | The Investigation of the Effect and Mechanism of Sophora moorcroftiana Alkaloids in Combination with Albendazole on Echinococcosis in an Experimental Rats Model. | Evidence-based complementary and alternative medicine : eCAM | 11 | 29785189 |
| 2014 | Cytoplasmic anchoring of cAMP-dependent protein kinase (PKA) by A-kinase anchor proteins (AKAPs) is required for meiotic arrest of porcine full-grown and growing oocytes. | Biology of reproduction | 11 | 24501172 |
| 2021 | Altered expression of lncRNAs in autism spectrum disorder. | Metabolic brain disease | 10 | 33587235 |
| 2021 | Detection of NTRK fusions in glioblastoma: fluorescent in situ hybridisation is more useful than pan-TRK immunohistochemistry as a screening tool prior to RNA sequencing. | Pathology | 10 | 34518039 |
| 2017 | MicroRNA profiling in the dentate gyrus in epileptic rats: The role of miR-187-3p. | Medicine | 10 | 28562528 |
| 2012 | Analyses of the involvement of PKA regulation mechanism in meiotic incompetence of porcine growing oocytes. | Biology of reproduction | 10 | 22674394 |
| 2021 | miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway. | iScience | 9 | 34761190 |
| 2020 | cAMP-dependent protein kinase A in grass carp Ctenopharyngodon idella: Molecular characterization, gene structure, tissue distribution and mRNA expression in endoplasmic reticulum stress-induced adipocyte lipolysis. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology | 9 | 32687978 |
| 2020 | Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation. | JCI insight | 9 | 33141766 |
| 2016 | Evaluation of the expression of sperm proteins in normozoospermic and asthenozoospermic men using monoclonal antibodies. | Asian journal of andrology | 9 | 25926605 |
| 2024 | Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†. | Biology of reproduction | 8 | 38847481 |
| 2018 | Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain. | Molecular neurobiology | 8 | 30264294 |
| 2015 | Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice. | Human molecular genetics | 8 | 26246497 |
| 2015 | Hematopoietic neoplasms in Prkar2a-deficient mice. | Journal of experimental & clinical cancer research : CR | 8 | 26608815 |
| 2022 | Circ_0000811 acts as a miR-15b sponge and inhibits Prkar2a-mediated JAK2/STAT1 pathway to attenuate cerebral ischemic vertigo. | Cell death discovery | 7 | 35508616 |
| 2021 | Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model. | Molecular genetics and metabolism reports | 7 | 33898262 |
| 2024 | Exploring resveratrol against Alzheimer's disease and Parkinson's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vitro. | Heliyon | 5 | 39328512 |
| 2022 | Corticosterone stage-dependently inhibits progesterone production presumably via impeding the cAMP-StAR cascade in granulosa cells of chicken preovulatory follicles. | Poultry science | 5 | 36608454 |
| 2021 | PRKA/PKA signals and autophagy: space matters. | Autophagy | 5 | 33971785 |
| 2020 | p-synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells. | Journal of toxicology and environmental health. Part A | 5 | 33292089 |
| 1998 | Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2. | Genomics | 5 | 9676433 |
| 2025 | Mapping Cophosphoregulation Networks Linked to Transcriptional Regulator Bromodomain-Containing Protein 4. | DNA and cell biology | 4 | 40501338 |
| 2016 | Investigation of the Effects and Mechanisms of Mai Tong Formula on Lower Limb Macroangiopathy in a Spontaneous Diabetic Rat Model. | Journal of diabetes research | 4 | 27995148 |
| 2025 | Transcriptome analysis reveals key genes and signalling pathways related to residual feed intake in meat-type ducks. | Animal : an international journal of animal bioscience | 2 | 40367888 |
| 2025 | Genome-Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms-Fish Hosts System and Drug Target Identification. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 2 | 41017714 |
| 2024 | Screening of key genes related to M6A methylation in patients with heart failure. | BMC cardiovascular disorders | 2 | 39415091 |
| 2014 | PKA regulatory subunit expression in tooth development. | Gene expression patterns : GEP | 2 | 24755349 |
| 2025 | Targeted multi-layer analysis of PANoptosis-associated genes in the etiology of chronic kidney disease. | Human genomics | 1 | 40361162 |
| 2026 | A Novel A-Kinase-Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series. | Molecular genetics & genomic medicine | 0 | 41574642 |
| 2026 | Genetic overlap between autoimmune disorders and anorexia nervosa: insights from a large-scale cross-trait genome-wide analysis. | Journal of eating disorders | 0 | 42216045 |
| 2025 | Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors. | Frontiers in veterinary science | 0 | 40351764 |
| 2025 | Casomorphine-10 (CM-10) Peptide Orchestrates Circadian and Neurodevelopmental Gene Clusters via δ-Opioid Receptor Signaling: Insights from Transcriptome Analysis with δ-Opioid Receptor-Expressing HEK293 Cells. | Life (Basel, Switzerland) | 0 | 41157308 |
| 2025 | Pork Quality and Expression of Genes Involved in Muscularity and Fat Deposition in Different Commercial Lines and Sexes of Pigs. | Animals : an open access journal from MDPI | 0 | 41375424 |
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