Affinage

Showing IFNGR1 — IFNGR is a alias.

IFNGR1

Interferon gamma receptor 1 · UniProt P15260

Length
489 aa
Mass
54.4 kDa
Annotated
2026-06-10
75 papers in source corpus 23 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IFNGR1 is the ligand-binding chain of the IFN-γ receptor that initiates JAK1-STAT1 signaling to drive IFN-γ-stimulated gene programs in immune and tissue cells (PMID:24048899, PMID:28542482). Surface abundance of IFNGR1 is the principal control point of this pathway and is set by multiple post-translational and trafficking mechanisms: S-palmitoylation at Cys122 directs AP3D1-dependent lysosomal sorting and degradation, a fate opposed by optineurin to stabilize surface receptor and sustain signaling (PMID:33627378), while ZDHHC3-driven Cys122 palmitoylation during bacterial infection routes the receptor to LAMP2+ lysosomes for degradation (PMID:37488798); recycling-endosome trafficking through TMEM199/CCDC115-mediated RAB11A activation promotes receptor re-display and downstream PD-L1 induction (PMID:41319859). Receptor levels are additionally constrained by ubiquitin-dependent proteasomal degradation via the E3 ligases FBXW7 (PMID:32284542) and RNF149, the latter forming a STAT1-induced negative-feedback loop that limits macrophage-driven inflammation (PMID:38989590). Transcriptional output is tuned both by type I IFN, which recruits a repressive Egr3/Nab1 complex to the ifngr1 promoter (PMID:23935197), and by IFN-γ itself through chromatin remodeling at enhancer sites, establishing autoregulatory feedback (PMID:31585982). Beyond canonical surface signaling, IFNGR1 undergoes ligand-dependent endocytosis and nuclear translocation, where it associates with STAT1α at the GAS promoter element and harbors transactivation activity (PMID:10888113, PMID:16785527). Dominant-negative truncations lacking the cytoplasmic domain accumulate at the cell surface due to impaired recycling, retain IFN-γ binding, and block wild-type receptor signaling, causing inherited partial IFN-γ receptor deficiency (PMID:10192386, PMID:17513528).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1999 High

    Established how cytoplasmic-domain truncations of IFNGR1 cause disease, showing the mutant acts dominantly rather than through simple haploinsufficiency.

    Evidence Cell-surface expression, IFN-γ binding, and signaling assays in patient-derived cells across 12 families

    PMID:10192386

    Open questions at the time
    • Molecular basis of the recycling defect was not resolved at the trafficking-machinery level
    • Did not identify the cytoplasmic motifs required for internalization
  2. 2000 Medium

    Revealed that IFNGR1, unlike IFNGR2, undergoes ligand-induced endocytosis and nuclear translocation in association with STAT1α, hinting at a non-canonical nuclear role.

    Evidence Immunofluorescence, Co-IP, and subcellular fractionation of IFN-γ-treated WISH cells

    PMID:10888113

    Open questions at the time
    • Single lab, no reciprocal validation in other cell types
    • Functional consequence of nuclear IFNGR1 not yet demonstrated
  3. 2006 Medium

    Demonstrated that nuclear IFNGR1 is recruited with IFN-γ and STAT1α to GAS elements and contains a transactivation domain, assigning a direct transcriptional function to a receptor chain.

    Evidence ChIP-PCR, EMSA, biotin-GAS pulldown, and GAL4-IFNGR1 fusion reporter assays

    PMID:16785527

    Open questions at the time
    • Quantitative contribution of nuclear IFNGR1 versus STAT1 to transcription not separated
    • Single lab
  4. 2008 Medium

    Showed that IFNGR1 promoter polymorphisms are functionally active and cell-type-dependent, linking genetic variation to receptor expression levels.

    Evidence Allele-specific and deletion/insertion luciferase reporter assays and EMSA across B-cells, epithelial cells, and T-cells

    PMID:16600993 PMID:18593809

    Open questions at the time
    • Reporter-based effects not validated at endogenous loci
    • Identity of binding factors only partially defined by size
  5. 2009 Medium

    Explained cell-type-selective partial IFNGR1 deficiency, showing leaky alternative translation initiation can rescue expression in some lineages.

    Evidence Western blot and signaling assays in patient fibroblasts versus EBV-B cells with translation initiation site analysis

    PMID:19880857

    Open questions at the time
    • Mechanism governing lineage-specific leaky initiation not defined
    • Single patient
  6. 2013 High

    Identified transcriptional silencing of ifngr1 by type I IFN and defined the receptor's role in dendritic cells, establishing that receptor levels and cell context shape antibacterial immunity.

    Evidence Egr-site reporter mutagenesis, ChIP, and Nab1 knockdown in macrophages; conditional Ifngr1 deletion in CD8α+ DCs with IL-4 neutralization rescue

    PMID:23935197 PMID:24048899

    Open questions at the time
    • How Egr3/Nab1 recruitment integrates with other repressors not defined
    • DC-intrinsic transcriptional targets downstream of IFNGR1 not enumerated
  7. 2017 High

    Established that surface IFNGR1 abundance is the decisive variable for IFN-γ responsiveness in vivo, by forcing expression to override type I IFN-induced down-regulation.

    Evidence Macrophage-specific FLAG-IFNGR1 transgenic mice in Listeria infection with IFN-γ-dependence tests; AAV-IFN-γ overexpression in Ifngr1−/− mice with behavioral and histopathology readouts

    PMID:28542482 PMID:29196213

    Open questions at the time
    • Trafficking machinery enforcing surface levels not yet identified at this stage
    • Neurodegeneration model does not isolate the responding cell type
  8. 2014 Medium

    Showed IFNGR1 can act in trans, delivered on extracellular vesicles complexed with IFN-γ to activate STAT1 in recipient cells.

    Evidence EV isolation, target-cell STAT1 phosphorylation with IFNGR1/STAT1 siRNA, and Co-IP of the IFN-γ/IFNGR1 complex on EVs

    PMID:25242146

    Open questions at the time
    • Physiological abundance and reach of receptor-bearing EVs unclear
    • Mechanism of EV loading not defined
  9. 2020 Medium

    Identified FBXW7 as an E3 ligase controlling IFNGR1 protein stability, linking proteasomal turnover to tumor IFN-γ signaling.

    Evidence FBXW7 loss-of-function, IFNGR1 stability and ubiquitination assays, and genetic rescue in TNBC cells and mice

    PMID:32284542

    Open questions at the time
    • Degron on IFNGR1 recognized by FBXW7 not mapped
    • Single lab
  10. 2021 High

    Defined the palmitoylation-driven lysosomal degradation axis and its mRNA-level sequestration counterpart, revealing two parallel ways tumors suppress IFN-γ sensing.

    Evidence Cys122 palmitoylation/mutagenesis, AP3D1 and optineurin Co-IP, lysosomal trafficking assays and tumor models; NEAT1_2/NONO RNA pulldown and RIP with T-cell killing assays

    PMID:33627378 PMID:33667716

    Open questions at the time
    • Palmitoyltransferase responsible in this context not identified here
    • Crosstalk between lysosomal and proteasomal degradation routes not resolved
  11. 2023 Medium

    Extended the palmitoylation mechanism to infection, identifying ZDHHC3 as the enzyme driving Cys122-dependent lysosomal degradation, and uncovered transcriptional activators of IFNGR1.

    Evidence ZDHHC3-dependent Click-iT palmitoylation, C122A mutagenesis and LAMP2 co-localization in P. gingivalis infection; JMJD2D-SP1 and RGS1-ATF3 ChIP-qPCR and reporter assays driving IFNGR1 transcription; MS identification of IFNGR1 in cancer EVs activating FRC PD-L1

    PMID:35027670 PMID:37482043 PMID:37488798 PMID:38264343

    Open questions at the time
    • Whether ZDHHC3 acts on IFNGR1 in non-infectious settings unclear
    • Transcriptional activator findings each from single labs
  12. 2024 High

    Established RNF149 as a STAT1-inducible E3 ligase forming a degradation-based negative-feedback loop, and delivered a first-in-class macrocyclic peptide inhibitor of the IFN-γ/IFNGR1 interaction.

    Evidence RNF149 KO/overexpression, Co-IP/MS, ubiquitination assays and bone marrow transplant in myocardial infarction; in vitro mRNA display selection of peptide IB1 with IC50 measurements and cellular validation

    PMID:38888290 PMID:38989590

    Open questions at the time
    • Relative weighting of RNF149 versus FBXW7 in different tissues unknown
    • In vivo efficacy of the peptide inhibitor not yet established
  13. 2025 Medium

    Mapped recycling-endosome control of IFNGR1 and demonstrated direct cell-type-specific IFN-γ effects through IFNGR1 in cardiomyocytes and ependymal cells.

    Evidence TMEM199/CCDC115-IFNGR1/2 Co-IP, RAB11A co-localization and PD-L1 readouts; cardiomyocyte- and ependymal-specific conditional Ifngr1 KO with metabolic imaging/metabolomics and permeability assays (preprints)

    PMID:41319859

    Open questions at the time
    • Cardiomyocyte and ependymal findings are preprints awaiting peer review
    • Integration of recycling pathway with degradative pathways not quantified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the competing degradative (palmitoylation/lysosomal, FBXW7, RNF149) and recycling (RAB11A) pathways are coordinated to set net surface IFNGR1 in a given cell remains unresolved.
  • No unified quantitative model balancing degradation versus recycling
  • Cell-type determinants selecting one fate over another unknown
  • Structural basis of the IFN-γ/IFNGR1 interface in human receptor not defined in this corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0048018 receptor ligand activity 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005634 nucleus 2 GO:0005764 lysosome 2 GO:0005768 endosome 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-5653656 Vesicle-mediated transport 2
Partners
AP3D1CCDC115FBXW7IFNGR2OPTNRNF149STAT1TMEM199
Complex memberships
IFN-γ receptor (IFNGR1/IFNGR2)

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 IFNGR1 frameshift small deletions producing truncated receptors that lack the intracytoplasmic domain act via a dominant-negative mechanism: the mutant protein accumulates at the cell surface (impaired recycling), abrogates signaling, but retains normal IFN-γ binding, thereby outcompeting wild-type receptor and blocking downstream signaling. Cell-surface expression analysis of patient-derived cells, IFN-γ binding assays, signaling assays in patient leukocytes, genetic characterization of dominant-negative inheritance Nature genetics High 10192386
2000 Following IFN-γ stimulation, IFNGR1 (but not IFNGR2) undergoes ligand-dependent endocytosis and nuclear translocation; IFNGR1 co-localizes and co-immunoprecipitates with STAT1α in the nucleus, while IFNGR2 remains predominantly at the cell surface. Immunofluorescence, immunoprecipitation, subcellular fractionation of WISH cells treated with IFN-γ Journal of interferon & cytokine research Medium 10888113
2006 IFNGR1 and IFN-γ are recruited to the GAS (IFN-γ-activated sequence) promoter element of IFN-γ-activated genes together with STAT1α as a macromolecular complex; IFNGR1 fused to the yeast GAL4 DNA-binding domain drives transcription from a GAL4 response element, indicating IFNGR1 contains a transactivation domain. Chromatin immunoprecipitation (ChIP)-PCR, EMSA, biotin-GAS pulldown of nuclear extracts, GAL4-IFNGR1 fusion reporter assay, GAS-luciferase co-transfection Journal of immunology Medium 16785527
2007 The 774del4 (and 818del4) dominant mutations in IFNGR1 produce truncated receptor that accumulates on the cell surface due to impaired receptor internalization/recycling, causing a dominant-negative effect on IFN-γ-induced STAT1 phosphorylation in HEK293 cells. Transient transfection of truncated IFNGR1 constructs in HEK293 cells, cell-surface FACS, STAT1 phosphorylation assay, peripheral blood CD14+ cell analysis from patient Journal of medical genetics Medium 17513528
2009 A homozygous mutation of the IFNGR1 initiation codon (M1K) eliminates IFN-γR1 expression in fibroblasts but permits residual expression in EBV-transformed B cells via leaky translation initiation at non-AUG and a downstream AUG codon (position 19), resulting in cell-type-specific partial IFNGR1 deficiency. Protein expression analysis (Western blot), IFN-γ signaling assays in patient fibroblasts and EBV-B cells, translation initiation site analysis Human molecular genetics Medium 19880857
2013 Type I IFN (IFN-β) rapidly silences ifngr1 transcription in macrophages by inducing recruitment of a repressive Egr3/Nab1 transcriptional complex to an Egr binding site in the proximal ifngr1 promoter, reducing activated RNA polymerase II and histone acetylation at the promoter. Actinomycin D chase, IFNGR1-luciferase reporter assay with Egr binding site mutation, ChIP for RNA pol II and acetylated histones, Nab1 knockdown in macrophage cell line, promoter-binding protein analysis Journal of immunology High 23935197
2013 Selective deletion of IFNGR1 in CD8α+ dendritic cells (Itgax-cre+Ifngr1f/f mice) impairs the initial IFN-γ-driven burst of IL-12 production needed to initiate anti-Listeria responses; neutralization of IL-4 (overproduced in its absence) restores Listeria resistance, placing IFNGR1 on CD8α+ DCs upstream of the IL-12/IL-4 axis in antibacterial immunity. Conditional knockout mice (Cre-lox), bacterial infection challenge, cytokine measurements, IL-4 neutralization rescue experiment Journal of immunology High 24048899
2014 IFNGR1 bound to extracellular vesicles (EVs) from neural stem cells—complexed with IFN-γ—activates STAT1 in target cells; this EV-mediated STAT1 activation requires endogenous STAT1 and IFNGR1 in the target cell. EV isolation and characterization, STAT1 phosphorylation assay in target cells, siRNA knockdown of IFNGR1/STAT1 in target cells, immunoprecipitation demonstrating IFN-γ/IFNGR1 complex on EVs Molecular cell Medium 25242146
2017 Macrophage-specific forced expression of IFNGR1 (via transgenic fGR1 mice) prevents type I IFN-induced down-regulation of surface IFNGR1, sustains IFN-γ responsiveness in the presence of type I IFNs, and enhances macrophage antimicrobial function during Listeria monocytogenes infection in an IFN-γ-dependent manner. Transgenic mice with macrophage-specific FLAG-tagged IFNGR1, Listeria infection model, IFN-γ–dependence experiments, macrophage activation assays PLoS pathogens High 28542482
2017 Canonical IFN-γ signaling through IFNGR1 and STAT1 is required for nigrostriatal neurodegeneration and midbrain calcinosis induced by brain overexpression of IFN-γ; Ifngr1−/− mice showed no neuroinflammation, calcinosis, or nigrostriatal pathology upon IFN-γ overexpression. AAV-mediated IFN-γ overexpression in Ifngr1−/− and Stat1−/− mice, rotarod behavioral testing, histopathology, bioinformatic analysis Neurobiology of disease High 29196213
2019 IFN-γ itself reduces surface IFNGR1 on myeloid cells (murine and human CD14+) by decreasing Ifngr1 transcription through altered chromatin structure at putative Ifngr1 enhancer sites—distinct from the type I IFN mechanism—thereby creating a negative feedback loop that blunts STAT1 and STAT3 activation. Flow cytometry of monocytes from infected mice and cultured cells, qPCR of Ifngr1 transcripts, chromatin accessibility assay at Ifngr1 enhancer sites, STAT1/3 phosphorylation assay Life science alliance Medium 31585982
2020 FBXW7 (regulated by the transcription factor ELF5) ubiquitinates IFNGR1 protein, targeting it for proteasomal degradation; loss of FBXW7 in TNBC stabilizes IFNGR1 protein and amplifies intrinsic IFN-γ signaling, promoting tumor progression. FBXW7 loss-of-function experiments, IFNGR1 protein stability assays, ubiquitination assays, genetic rescue experiments in TNBC cells and mouse models Nature cell biology Medium 32284542
2021 IFNGR1 is S-palmitoylated at Cys122; palmitoylated IFNGR1 is recognized by AP3D1, which sorts it to lysosomes for degradation. Optineurin interacts with AP3D1 to prevent this lysosomal sorting, thereby stabilizing IFNGR1 at the cell surface and maintaining IFN-γ signaling. Loss of optineurin in colorectal cancer increases IFNGR1 palmitoylation-dependent lysosomal degradation and impairs IFN-γ signaling. Palmitoylation assay (Click chemistry/acyl-RAC), Co-IP of AP3D1 with IFNGR1 and optineurin, site-directed mutagenesis of Cys122, lysosomal trafficking assay, pharmacological inhibition of palmitoylation, mouse tumor models Cancer discovery High 33627378
2021 Paraspeckle protein NONO and the lncRNA NEAT1_2 sequester IFNGR1 mRNA within paraspeckles in HCC cells, reducing IFNGR1 protein expression and impairing IFN-γ/IFNGR1 signaling, thereby promoting resistance to T-cell-mediated cytolysis. CRISPR-Cas9 knock-in S1-aptamer pull-down of NEAT1_2 interactors followed by sequencing, RNA immunoprecipitation (RIP), NONO/NEAT1_2 knockdown, Western blotting, T-cell killing assay Cellular and molecular gastroenterology and hepatology Medium 33667716
2022 Histone demethylase JMJD2D coactivates SP1 to transcriptionally upregulate IFNGR1, which then elevates STAT3-IRF1 signaling and PD-L1 transcription in colorectal cancer; JMJD2D also directly coactivates the STAT3-IRF1 axis at the PD-L1 promoter in a demethylation-dependent manner. Genetic ablation of JMJD2D, RT-qPCR, Western blotting, ChIP-qPCR, luciferase reporter assay, flow cytometry, mouse tumor models Oncogene Medium 35027670
2023 RGS1 enhances binding of the transcription factor ATF3 to the IFNGR1 promoter, thereby increasing IFNGR1 expression, activating downstream STAT1 signaling and IFN-γ-inducible gene expression (including CXCL9 and MHC-I), and supporting CD8+ T cell infiltration. ChIP-qPCR, dual-luciferase reporter assay, RT-qPCR, Western blotting, flow cytometry, mouse tumor models Oncoimmunology Medium 38264343
2024 The E3 ubiquitin ligase RNF149 promotes ubiquitylation-dependent proteasomal degradation of IFNGR1 in macrophages; STAT1 activation induces Rnf149 transcription, which in turn destabilizes IFNGR1, creating a negative feedback loop that fine-tunes type II IFN signaling and limits macrophage-driven inflammation after myocardial infarction. RNF149 KO and overexpression, bone marrow transplantation, immunoprecipitation/mass spectrometry, ubiquitination assay, transcriptome analysis, flow cytometry, cardiac function measurements Circulation research High 38989590
2024 Macrocyclic l-α/d-α/β/γ-hybrid peptide IB1 selected by in vitro display inhibits the IFN-γ/IFNGR1 protein-protein interaction with IC50 = 12 nM in biochemical assay and ~0.75 μM at the cellular level; the presence of a cyclic β-amino acid (cβAA) in the sequence was identified as the primary contributor to inhibitory activity. In vitro mRNA display selection against recombinant IFNGR1, biochemical PPI inhibition assay (IC50 measurement), cellular IFN-γ/IFNGR1 inhibition assay, mutagenesis of non-proteinogenic residues Journal of the American Chemical Society High 38888290
2023 IFNGR1 contained in cancer-cell-derived extracellular vesicles can be engulfed by fibroblastic reticular cells (FRCs) in lymph nodes and activate PD-L1 expression via the JAK1-STAT1 pathway, promoting CD8+ T cell exhaustion and pre-metastatic niche formation. Mass spectrometry identification of IFNGR1 in CEVs, Western blotting for JAK1-STAT1 pathway activation, co-culture of FRCs with CEVs, T cell cytotoxicity assay, flow cytometry Oral oncology Medium 37482043
2025 TMEM199, together with its partner CCDC115, interacts with IFNGR1/2 and facilitates their trafficking to RAB11A-positive recycling endosomes; TMEM199/CCDC115 recruits TRAPP II to activate RAB11A, enhancing IFNGR1/2 recycling and downstream IFN-γ-driven PD-L1 upregulation. Co-immunoprecipitation of TMEM199/CCDC115 with IFNGR1/2, RAB11A recycling endosome co-localization assay, loss-of-function experiments, PD-L1 reporter/protein assay Cancer letters Medium 41319859
2023 Porphyromonas gingivalis infection promotes S-palmitoylation of IFNGR1 at Cys122 (via ZDHHC3), driving IFNGR1 co-localization with the lysosomal marker LAMP2 and lysosomal degradation, thereby reducing IFNGR1 protein levels; mutation of Cys122 (IFNGR1-C122A) partially attenuates Pg-induced IFNGR1 degradation and reduces cancer cell proliferation, migration, and invasion. 2-BP palmitoylation inhibitor assay, site-directed mutagenesis (C122A), Click-iT palmitoylation assay, immunofluorescence co-localization with LAMP2, cell proliferation/migration/invasion assays Nan fang yi ke da xue xue bao Medium 37488798
2006 A deletion/insertion polymorphism at IFNGR1-470 in the IFNGR1 promoter has cell-type-specific opposite functional effects: in B-lymphocytes it suppresses binding of a ~35 kDa nuclear protein and increases reporter gene expression; in epithelial cells it decreases reporter expression and suppresses binding of ~90 kDa STAT-1 and STAT-2 proteins; in T-lymphocytes it has no significant effect on gene expression. EMSA (electrophoretic mobility shift assay) with nuclear extracts, luciferase reporter assay in B-lymphocytes, epithelial cells, and T-lymphocytes Human molecular genetics Medium 16600993
2008 The IFNGR1 −56C/T promoter polymorphism is functionally relevant: the −56T allele drives approximately 10-fold higher luciferase reporter expression compared to the −56C allele in a cell-based assay. Allele-specific IFNGR1 −56C/T luciferase reporter assay Gut Medium 18593809
2025 Cardiomyocyte-specific deletion of IFNGR1 (Myh6Cre Ifngr1fl/fl mice) abrogates IFN-γ-induced cardiac metabolic reprogramming (increased glucose uptake, reduced fatty acid oxidation and oxidative phosphorylation), establishing that IFN-γ drives cardiac metabolic changes via direct signaling through IFNGR1 on cardiomyocytes. Conditional cardiomyocyte-specific KO mice, AAV-Ifng overexpression model, echocardiography, bulk RNA-seq, in vivo PET imaging ([18F]FDG and [18F]fluoro-6-thia-heptadecanoic acid), isolated mitochondrial oxygen consumption, targeted metabolomics bioRxivpreprint Medium
2025 Conditional knockout of Ifngr1 in ependymal cells (in a murine model) prevents IFN-γ-induced increases in ependymal permeability, establishing that IFNGR1 on ependymal cells mediates IFN-γ-driven barrier dysfunction relevant to periventricular pathology. Conditional Ifngr1 knockout in ependymal cells, ependymal permeability assay following IFN-γ treatment bioRxivpreprint Low

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nature genetics 352 10192386
2014 Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells. Molecular cell 250 25242146
2021 Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation. Cancer discovery 112 33627378
2020 Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Nature cell biology 90 32284542
2002 IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. The Journal of infectious diseases 80 12023780
2009 NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Human genetics 69 19575238
2000 Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 59 10888113
2003 Genetic susceptibility to visceral leishmaniasis in The Sudan: linkage and association with IL4 and IFNGR1. Genes and immunity 58 12847550
1997 Infections in IFNGR-1-deficient children. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 58 9355958
2013 Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1). Journal of immunology (Baltimore, Md. : 1950) 55 24048899
2007 Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Human genetics 52 17431682
2006 IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1. Journal of immunology (Baltimore, Md. : 1950) 46 16785527
2013 Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. Journal of immunology (Baltimore, Md. : 1950) 44 23935197
2008 The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut 43 18593809
2006 IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan. Genes and immunity 38 17136124
2017 IFN-γR1 defects: Mutation update and description of the IFNGR1 variation database. Human mutation 37 28744922
2015 Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. The Journal of allergy and clinical immunology 36 26343451
2014 Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis. Gene 32 24680779
2009 A novel form of cell type-specific partial IFN-gammaR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon. Human molecular genetics 30 19880857
2022 Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. Oncogene 28 35027670
2012 An association study of functional polymorphic genes IRF-1, IFNGR-1, and IFN-γ with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 27 23040881
1999 Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels. Biochemical and biophysical research communications 27 10491309
2017 Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. PLoS pathogens 26 28542482
2007 The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction. Journal of medical genetics 25 17513528
2021 Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet's Disease. Arthritis & rheumatology (Hoboken, N.J.) 23 33393726
1989 Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24. Human genetics 23 2532616
2010 Analysis of functional SNP in ifng/ifngr1 in Chinese Han population with tuberculosis. Scandinavian journal of immunology 19 20500698
2019 Genetic variants in IFNG and IFNGR1 and tuberculosis susceptibility. Cytokine 17 31310896
2006 Context-specific functional effects of IFNGR1 promoter polymorphism. Human molecular genetics 17 16600993
2019 Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition. Scientific reports 16 31015500
2011 Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation. European journal of human genetics : EJHG 16 21731057
2018 Analysis of the expression patterns of the cytokine receptor family B (CRFB) and interferon gamma receptor (IFNGR) in Dabry's sturgeon (Acipenser dabryanus). Developmental and comparative immunology 15 29555551
2023 Cancer cell-derived extracellular vesicles drive pre-metastatic niche formation of lymph node via IFNGR1/JAK1/STAT1-activated-PD-L1 expression on FRCs in head and neck cancer. Oral oncology 14 37482043
2022 IFN-γ promotes the development of systemic lupus erythematosus through the IFNGR1/2-PSTAT1-TBX21 signaling axis. American journal of translational research 14 36398225
2021 Induced Mitochondrial Alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 Pathway Facilitates Viral Hepatitis Associated Hepatocellular Carcinoma Aggressiveness and Stemness. Cancers 14 34199353
2014 Two IFNGR1 homologues in Tetraodon nigroviridis: Origin, expression analysis and ligand-binding preference. Developmental and comparative immunology 14 24412214
2003 Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. Immunogenetics 14 12743658
2021 Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA. Cellular and molecular gastroenterology and hepatology 13 33667716
2019 Analysis of interferon-γ receptor IFNGR1 and IFNGR2 expression and regulation at the maternal-conceptus interface and the role of interferon-γ on endometrial expression of interferon signaling molecules during early pregnancy in pigs. Molecular reproduction and development 13 31680343
2019 Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection. Disease markers 13 31687049
2024 RNF149 Destabilizes IFNGR1 in Macrophages to Favor Postinfarction Cardiac Repair. Circulation research 12 38989590
2017 IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites. PloS one 12 29117241
2023 Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis. Oncoimmunology 11 38264343
2020 Promoting effect of long non-coding RNA SNHG1 on osteogenic differentiation of fibroblastic cells from the posterior longitudinal ligament by the microRNA-320b/IFNGR1 network. Cell cycle (Georgetown, Tex.) 11 33017569
2017 Association of IFNGR1 and IFNG genetic polymorphisms with the risk for pulmonary tuberculosis in the Chinese Tibetan population. Oncotarget 11 29228700
2017 Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration. Neurobiology of disease 10 29196213
2014 Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 10 24453034
2015 Association of Genetic Polymorphisms of IFNGR1 with the Risk of Pulmonary Tuberculosis in Zahedan, Southeast Iran. Tuberculosis research and treatment 9 26649196
2009 IFNGR1 polymorphisms in Thai malaria patients. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 9 19712753
2014 Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients. BMC infectious diseases 7 25466928
2024 In Vitro Selection of Macrocyclic l-α/d-α/β/γ-Hybrid Peptides Targeting IFN-γ/IFNGR1 Protein-Protein Interaction. Journal of the American Chemical Society 6 38888290
2023 S100A9 upregulated by IFNGR signaling blockade functions as a novel GVHD suppressor without compromising GVL in mice. Blood 6 36477272
2023 [Effect of Porphyromonas gingivalis infection on IFNGR1 palmitoylation in esophageal cancer cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 6 37488798
2019 Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness. Life science alliance 5 31585982
2019 Disseminated Mycobacterium Avium Infection in a Child with Complete Interferon-γ Receptor 1 Deficiency due to Compound Heterozygosis of IFNGR1 for a Subpolymorphic Copy Number Variation and a Novel Splice-Site Variant. Journal of pediatric genetics 5 32714620
2010 Lack of association between IFNGR1 gene polymorphisms and biopsy-proven giant cell arteritis. Clinical and experimental rheumatology 5 20412699
2024 CAV1 inhibits Xc- system through IFNGR1 to promote ferroptosis to inhibit stemness and improves anti-PD-1 efficacy in breast cancer. Translational oncology 4 39395272
2023 Identification, functional characterization and expression pattern of interferon-gamma (IFN-γ) and interferon-gamma receptor 1 (IFNGR1) in Nibea albiflora. Fish & shellfish immunology 4 38072135
2022 Case Report: Disseminated Mycobacterium intracellulare Infection With More Than 1-Year Follow-Up in a Young Boy With IFNGR1 Deficiency. Frontiers in pediatrics 4 35281241
2022 Interferon gamma upregulates the cytokine receptors IFNGR1 and TNFRSF1A in HT-29-MTX E12 cells. Cytokine 4 35653895
2024 The aqueous extract of Armadillidium vulgare Latreille alleviates neuropathic pain via inhibiting neuron-astrocyte crosstalk mediated by the IL-12-IFN-γ-IFNGR-CXCL10 pathway. Journal of ethnopharmacology 3 39617087
2022 Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis. Frontiers in public health 3 36148347
2022 IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study. European review for medical and pharmacological sciences 3 36524496
2021 Genetic Polymorphisms of IFNG, IFNGR1, and Androgen Receptor and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in a Chinese Han Population. Disease markers 3 34646402
2016 Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. Bosnian journal of basic medical sciences 3 27356097
2024 Elevated NS1 serum levels reduce CD119 expression and CXCL-10 synthesis in patients with dengue hemorrhagic fever. Revista da Sociedade Brasileira de Medicina Tropical 2 39082520
2008 Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours. European journal of human genetics : EJHG 2 18414508
2025 TMEM199 promotes PD-L1 expression and tumor immune evasion by activating the recycling of IFNGR1/2. Cancer letters 1 41319859
2006 IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis. Arthritis research & therapy 1 16563189
2025 IFNGR1, IRF8 genetic polymorphisms modulate the susceptibility of non-tuberculous mycobacteria pulmonary disease and influence the patients' treatment outcomes and immune status. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 0 40691380
2025 Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis. Plastic and reconstructive surgery. Global open 0 40827246
2025 Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease. International journal of molecular sciences 0 41009374
2023 [Analysis of IFN-γR1 (CD119) and IL-12Rβ1 (CD212) Deficiency by Flow Cytometry]. Mikrobiyoloji bulteni 0 36636848
2023 Talaromyces marneffei infection with IFNGR1 gene mutation in a patient with negative Anti-Interferon-γ autoantibodies. Anais brasileiros de dermatologia 0 37926601
1992 TaqI RFLP in the interferon gamma receptor 1 gene (IFNGR1) on human chromosome 6q. Nucleic acids research 0 1372404

Missed literature

Know a paper Affinage missed for IFNGR1? Flag it for the maintainers and the community.

No submissions yet.