Affinage

POSTN

Periostin · UniProt Q15063

Length
836 aa
Mass
93.3 kDa
Annotated
2026-04-28
100 papers in source corpus 26 papers cited in narrative 26 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Periostin (POSTN) is a secreted matricellular protein that orchestrates cell adhesion, migration, survival, myofibroblast differentiation, and extracellular matrix remodeling across developmental, fibrotic, immune, and neoplastic contexts. It signals primarily through integrin receptors (αvβ3, α6β4, β1) to activate FAK, PI3K/AKT, ERK/MAPK, NF-κB, and Rho/ROCK cascades, thereby controlling processes ranging from atrioventricular valvulogenesis and collagen fibrillogenesis to epithelial-mesenchymal transition and tumor-associated immunosuppression (PMID:24469446, PMID:25003192, PMID:39227950, PMID:25421393). Its expression is induced by TGF-β/Smad signaling, mechanical stress, Wnt-3 (β-catenin-independent), and HIF-1α, and the protein is phosphorylated extracellularly by the Golgi kinase FAM20C on its Fasciclin I domains (PMID:20940356, PMID:25870205, PMID:10884377, PMID:32752980, PMID:33051588). Isoform-specific functions are functionally significant: a short exon-17-lacking isoform on exosome surfaces activates FAK/YAP to drive cardiomyocyte proliferation, whereas full-length periostin does not, and in periostin-expressing pulmonary myofibroblasts PIEZO1-mediated mechanosensation sustains fibrotic activation through YAP/TAZ nuclear localization (PMID:33897872, PMID:40454481).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2000 Medium

    Identification of the upstream Wnt pathway controlling POSTN expression resolved whether its regulation involved canonical β-catenin signaling, establishing that Wnt-3 induces periostin through a β-catenin-independent mechanism.

    Evidence Wnt-3 viral infection, GSK-3 inhibition, and β-catenin overexpression/antisense in mouse mammary epithelial cells

    PMID:10884377

    Open questions at the time
    • Downstream effectors of the non-canonical Wnt branch driving POSTN remain unidentified
    • Not tested in mesenchymal cell types where periostin is most abundant
  2. 2004 Medium

    Mapping periostin expression to developing cardiac cushions and trabeculae, with induction by TGF-β and BMP, established it as an integrin-binding matricellular factor in heart morphogenesis.

    Evidence In situ hybridization and Northern analysis in chick cardiac development

    PMID:15532025

    Open questions at the time
    • No loss-of-function data at this stage
    • Specific integrin partners in cardiac tissue not identified
  3. 2010 Medium

    Demonstrating that both TGF-β1 and mechanical strain converge on FAK to induce periostin expression answered how mechanical loading is transduced to matrix remodeling gene programs.

    Evidence Cyclic strain on PDL fibroblasts with FAK inhibition and FAK-null fibroblasts

    PMID:20940356

    Open questions at the time
    • FAK-dependent transcription factor mediating POSTN induction not identified
    • Tested only in periodontal ligament fibroblasts
  4. 2012 Medium

    Showing that periostin promotes lymphangiogenesis via Src/Akt activation and VEGF-C upregulation extended its functional repertoire beyond matrix adhesion to vascular remodeling in tumors.

    Evidence Conditioned media tube formation assays with kinase inhibitors and xenograft correlation in HNSCC

    PMID:22952986

    Open questions at the time
    • Receptor on lymphatic endothelial cells not defined
    • No genetic loss-of-function in vivo
  5. 2014 High

    Multiple studies defined the specific integrin–effector cascades through which periostin acts: α6β4/JNK suppresses PPARα in hepatocytes causing steatosis; integrins/FAK/PI3K/AKT/ERK drive valvulogenesis; and periostin on dendritic cells is required for maximal allergic airway inflammation.

    Evidence KO mice, neutralizing antibodies, integrin blockade, explant cultures in liver, heart, and airway models; DC adoptive transfer restoring allergic responses in Postn−/− mice

    PMID:24469446 PMID:24996263 PMID:25003192

    Open questions at the time
    • How periostin selectively engages different integrin heterodimers in different tissues is unknown
    • Structural basis for integrin selectivity not resolved
  6. 2015 Medium

    Periostin was shown to sustain myofibroblast persistence via ROCK-dependent proliferation and α-SMA maintenance, and its expression under compressive force was confirmed to require TGF-β1 signaling, linking mechanical loading to fibrotic matrix remodeling.

    Evidence 3D collagen contraction with ROCK inhibitor in scar fibroblasts; compressive force apparatus with TGF-β1 inhibitor/neutralizing antibody in PDL fibroblasts; Schwann cell migration assays in Postn-KO DRG explants

    PMID:25421393 PMID:25870205 PMID:26187852

    Open questions at the time
    • Whether ROCK activation is integrin-dependent not tested directly
    • Periostin's role in nerve repair beyond Schwann cell migration not explored
  7. 2016 High

    Demonstrating that fibrocyte-secreted periostin drives myofibroblast differentiation via β1-integrin and upregulates CTGF and LOX established periostin as a paracrine amplifier of pulmonary fibrosis.

    Evidence Adoptive transfer of WT vs Postn−/− fibrocytes in bleomycin model with in vitro receptor identification

    PMID:27435108

    Open questions at the time
    • Downstream signaling from β1-integrin to CTGF/LOX transcription not dissected
    • Relevance to human IPF fibrosis not directly demonstrated
  8. 2020 High

    A burst of studies in 2020 extended periostin signaling to new receptors (DDR1 in chondrocytes), new effectors (NF-κB/ADAMTS5 in cartilage resorption, integrin-β1/RhoA in palatal wound healing), renal protection (integrin-β1 on tubular cells inhibiting apoptosis and promoting macrophage proliferation), and tumor immunosuppression (αvβ3/PI3K/AKT/NF-κB recruiting immunosuppressive microglia in glioblastoma).

    Evidence DDR1-KO chondrocytes and pharmacological inhibition; NF-κB inhibitor rescue; Postn−/− palatal wound model; conditional tubule-specific overexpression and Postn-KO in renal IRI; POSTN-depleted GSCs with ChIP-seq, tumorsphere assays, and orthotopic xenografts

    PMID:31690575 PMID:31840212 PMID:32330138 PMID:32777343 PMID:39227950

    Open questions at the time
    • DDR1 as a periostin receptor has not been confirmed by direct binding assay
    • Whether NF-κB activation in tumors versus cartilage uses the same receptor is unknown
    • Relative contribution of autocrine versus paracrine periostin in GBM niche not resolved
  9. 2020 Medium

    Discovery of a HIF-1α–periostin positive feedback loop via TrkB in pulmonary hypertension revealed how periostin self-amplifies its own expression in hypoxic vascular disease, also linking to ET-1 and VEGF production.

    Evidence siRNA knockdown epistasis of HIF-1α, POSTN, and TrkB in hPAECs; Sugen/hypoxia and chronic hypoxia mouse PH models

    PMID:32752980

    Open questions at the time
    • Direct physical interaction between periostin and TrkB not demonstrated
    • Whether this feedback loop operates in other hypoxic tissues is untested
  10. 2020 High

    Identification of FAM20C as a direct kinase that phosphorylates periostin Fasciclin I domains provided the first post-translational modification mechanism, showing that the interaction is kinase-activity-independent for binding but required for phosphorylation.

    Evidence In vitro kinase assay with WT and kinase-dead D478A FAM20C, domain mapping pulldown, co-localization in PDL ECM

    PMID:33051588

    Open questions at the time
    • Phosphorylation sites on periostin not mapped
    • Functional consequence of FAM20C-mediated phosphorylation on periostin activity unknown
  11. 2021 High

    Demonstrating that a short periostin isoform (lacking exon 17) on exosome surfaces—but not full-length periostin—drives cardiomyocyte cell-cycle re-entry via FAK/YAP established the first clear isoform-specific function.

    Evidence Cryo-EM immune-gold labeling, isoform-specific antibodies, FAK inhibitor, YAP siRNA, neonatal rat and human iPSC-derived cardiomyocytes in vitro and in vivo post-MI

    PMID:33897872

    Open questions at the time
    • Mechanism by which exon 17 deletion alters integrin engagement or FAK activation is unknown
    • Whether this isoform is generated by regulated alternative splicing or constitutive remains unclear
  12. 2023 Medium

    Periostin was linked to metabolic regulation via TGF-β/Smad-induced NAP1L2 upregulation, which recruits SIRT3 to deacetylate H3K27ac at BCAA catabolism gene promoters, connecting periostin to diabetic cardiomyopathy through impaired branched-chain amino acid metabolism.

    Evidence RNA-seq, ChIP for H3K27ac, gain/loss-of-function in diabetic mice and cardiac fibroblasts, TGF-β pathway inhibition

    PMID:37993768

    Open questions at the time
    • Whether periostin-NAP1L2 axis operates outside the diabetic heart is untested
    • Direct paracrine effect of fibroblast-derived periostin on cardiomyocyte BCAA metabolism not shown
  13. 2025 High

    Conditional deletion of PIEZO1 in periostin-expressing myofibroblasts revealed that mechanosensation through PIEZO1 is required for YAP/TAZ nuclear localization and sustained fibrotic activation, with Yap/Taz deletion fully phenocopying PIEZO1 loss, placing PIEZO1 upstream of YAP/TAZ in periostin-lineage cells.

    Evidence Postn-CreERT2 lineage tracing, conditional Piezo1 KO and Yap/Taz double KO in Postn+ cells, bleomycin fibrosis model

    PMID:40454481

    Open questions at the time
    • Whether PIEZO1 signals through integrins or independently of periostin-integrin axis is unresolved
    • Applicability to non-pulmonary fibrotic organs not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis for isoform-specific and tissue-specific integrin engagement; the identity and functional consequences of FAM20C phosphorylation sites; and how periostin coordinates its distinct roles in fibrosis, immunity, and tumor immunosuppression at the single-cell level.
  • No crystal structure of periostin bound to any integrin
  • Phosphosite mapping and functional phosphomutant studies lacking
  • Single-cell resolution of periostin paracrine circuits not yet achieved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098772 molecular function regulator activity 4 GO:0098631 cell adhesion mediator activity 3
Localization
GO:0005576 extracellular region 4 GO:0031012 extracellular matrix 3 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1474244 Extracellular matrix organization 4 R-HSA-1643685 Disease 4 R-HSA-1266738 Developmental Biology 3 R-HSA-168256 Immune System 2
Partners
DDR1FAM20CITGA6ITGAVITGB1ITGB3ITGB4YAP1

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 Periostin activates integrin α6β4 on hepatocytes, triggering JNK signaling pathway activation, which leads to c-Jun activation that prevents RORα binding at the Ppara promoter, thereby suppressing PPARα expression and promoting hepatic steatosis and hypertriglyceridemia. In vitro hepatocyte assays with integrin blockade, overexpression/knockout mouse models, neutralizing antibody, promoter binding studies The Journal of clinical investigation High 25003192
2014 Periostin binds to integrin receptors in valve progenitor cushion cells and activates focal adhesion kinase (FAK), PI3K/AKT, and ERK signaling pathways, promoting cell adhesion, migration, anti-apoptosis, collagen expression, and hyaluronan synthase-2 (Has2) activation during atrioventricular valvulogenesis. Explant cultures, gene transfection, Western blotting, functional assays with PN-null vs WT mice, 3D collagen compaction assay The Journal of biological chemistry High 24469446
2020 Periostin interacts with integrin-β1 on tubular epithelial cells to inhibit cell cycle arrest and apoptosis after ischemia-reperfusion injury; periostin from overexpressing tubules directly induces macrophage proliferation and expression of proregenerative molecules. Conditional tubule-specific overexpression mice, periostin-KO mice, in vivo ischemia-reperfusion model, in vitro hypoxia-reoxygenation, co-culture of macrophages with recombinant periostin Journal of the American Society of Nephrology : JASN High 31690575
2016 Fibrocyte-secreted periostin promotes myofibroblast differentiation via beta-1 integrin as its receptor on fibrocytes, and upregulates connective tissue growth factor (CTGF) and lysyl oxidase (LOX) mRNA in fibrocytes to augment pulmonary fibrosis. Conditioned medium experiments, adoptive transfer of WT vs periostin-/- fibrocytes, in vitro TGFβ1 and recombinant periostin treatment, bleomycin fibrosis model Mucosal immunology High 27435108
2020 CAF-derived periostin functions as a ligand for integrin αvβ3, activating the PI3K/Akt pathway and inducing EMT to drive migration and invasion of ovarian cancer cells; TGF-β1-induced fibroblast activation partly relies on periostin upregulation. Lentiviral knockdown/overexpression, Transwell migration/invasion assays, RNA sequencing, Western blotting, indirect co-culture Gynecologic oncology Medium 33317907
2012 Periostin promotes tumor lymphangiogenesis directly by stimulating tube formation of lymphatic endothelial cells (mediated by Src and Akt activity) and indirectly by upregulating VEGF-C mRNA expression in head and neck squamous cell carcinoma cells. Periostin overexpression in cancer cells, conditioned media tube formation assays with lymphatic endothelial cells, correlation with VEGF-C in HNSCC cases and serum, xenograft tumors PloS one Medium 22952986
2010 TGF-β1 induces periostin expression in PDL fibroblasts via a focal adhesion kinase (FAK)-dependent pathway; cyclic mechanical strain also upregulates periostin mRNA through FAK, as FAK-null fibroblasts lack detectable periostin mRNA even under strain. Cyclic strain application to PDL fibroblasts, FAK inhibition, FAK-null fibroblasts, TGF-β1 treatment, qRT-PCR Journal of dental research Medium 20940356
2015 Periostin promotes Rho-associated protein kinase (ROCK)-dependent proliferation and myofibroblast persistence in hypertrophic scar fibroblasts; matrix-associated periostin maintains high α-smooth muscle actin levels under reducing matrix tension, and ROCK inhibition attenuates these periostin effects. Recombinant periostin supplementation of collagen substrate, 3D collagen lattice contraction assays, ROCK inhibitor treatment, periostin siRNA knockdown in myofibroblasts Experimental dermatology Medium 25421393
2020 Periostin modulates myofibroblast differentiation and contraction via the integrin-β1/RhoA pathway, and regulates fibronectin synthesis in an ECM stiffness-dependent manner during palatal healing; periostin is required for formation of focal and fibrillar adhesions in palatal fibroblasts. Postn-/- knockout vs WT mice with palatal wounds, fibroblasts on silicon substrates of varying stiffness, collagen gel contraction, Rac inhibition rescue, immunostaining for vinculin and integrin-β1 Matrix biology : journal of the International Society for Matrix Biology Medium 32777343
2021 A short periostin isoform (lacking exon 17, aa 22–669) expressed on the surface of CPC-derived exosomes promotes cardiomyocyte cell cycle re-entry by activating FAK phosphorylation, actin polymerization, and nuclear translocation of YAP; full-length recombinant periostin does not induce this proliferative effect, demonstrating isoform-specificity. Cryo-EM with immune-gold labeling, Western blot with isoform-specific antibodies, siRNA knockdown of periostin or YAP, FAK inhibitor (PF-573228), neonatal rat cardiomyocytes in vitro and in vivo after MI, human iPS-derived cardiomyocytes Theranostics High 33897872
2020 Periostin signals through discoidin domain receptor-1 (DDR1), a receptor tyrosine kinase, to induce collagen and proteoglycan degradation in chondrocytes via downstream MMP-13 and ADAMTS4 expression; genetic deficiency or pharmacological inhibition of DDR1 blocks periostin-induced MMP-13 expression. DDR1 KO mouse chondrocytes, DDR1 pharmacological inhibitor, in vitro periostin stimulation, MMP-13 expression readout PloS one Medium 32330138
2020 Periostin induces IκBα phosphorylation and degradation leading to p65 nuclear translocation and ADAMTS5 upregulation in chondrocytes, mediating condylar resorption; NF-κB inhibition (BAY 11-7082) rescues periostin-induced ADAMTS5 upregulation. In vitro pressure-induced periostin expression in chondrocytes, Western blot for NF-κB pathway components, NF-κB inhibitor treatment, immunohistochemistry in TMJ-OA cartilage Inflammation Medium 31840212
2020 FAM20C (Golgi casein kinase) directly binds periostin through the Fasciclin I domains 1–4 and phosphorylates periostin in vitro; binding is kinase-activity-independent, and FAM20C and periostin co-localize in periodontal ligament extracellular matrix. Pulldown with WT and kinase-dead D478A FAM20C, mass spectrometry identification, in vitro binding assay, domain mapping, in vitro kinase assay, immunohistochemistry co-localization Scientific reports High 33051588
2019 Periostin overexpression in pulmonary hypertension activates HIF-1α, increasing ET-1 and VEGF production in endothelial cells; siRNA knockdown of HIF-1α abolishes the pro-angiogenic effect of periostin; TrkB (tyrosine kinase receptor B) mediates the effect of periostin on HIF-1α, and HIF-1α in turn drives POSTN expression, forming a positive feedback loop. siRNA knockdown of HIF-1α and POSTN in hPAECs, TrkB inhibition, POSTN overexpression, mouse PH models (Sugen 5416/hypoxia and chronic hypoxia), genetic epistasis Circulation research Medium 32752980
2000 Periostin expression is regulated by Wnt-3 signaling through a beta-catenin-independent pathway; Wnt-3 infection and GSK-3 inhibition upregulate periostin, but beta-catenin overexpression or antisense knockdown has no effect on periostin expression in mouse mammary epithelial cells. Wnt-3 viral infection, GSK-3 inhibition, beta-catenin overexpression, beta-catenin antisense oligonucleotide, gene expression profiling The Journal of biological chemistry Medium 10884377
2015 Intermittent compressive force increases POSTN (periostin) expression in human PDL fibroblasts via TGF-β1 signaling; TGF-β1 inhibition with SB431542 or TGF-β1 neutralizing antibody attenuates force-induced POSTN expression, and TGF-β1 accumulates intracellularly/in surrounding matrix (not secreted into medium) in response to force. Computerized compressive force loading apparatus, TGF-β1 inhibitor, neutralizing antibody, cycloheximide treatment, qRT-PCR, Western blot, ELISA Journal of dental research Medium 25870205
2015 Periostin promotes migration of Schwann cell precursors; periostin expression is induced by neuregulin-1 (NRG1, via ErbB receptors) and TGF-β1 in Schwann cells; DRG explant cultures from periostin-deficient mice show significantly reduced numbers of migrating Schwann cells. Comparative gene expression analysis of ErbB3-deficient vs WT DRG cultures, NRG1/TGFβ-1 stimulation, periostin-KO DRG explant cultures, migration quantification Journal of cell science Medium 26187852
2014 Periostin deficiency abrogates hepatic fibrosis in mice; periostin co-localizes with hepatic stellate cell-derived collagen I and α-SMA; TGF-β1 markedly induces periostin expression in primary mouse hepatic stellate cells; periostin-deficient mice show lower TGF-β1 and TGF-β2 levels after liver injury. Periostin-KO mice, carbon tetrachloride and bile duct ligation models, primary hepatic stellate cell cultures, immunohistochemistry co-localization, mRNA analysis The American journal of pathology Medium 25541330
2019 Periostin mediates EMT in hepatoblastoma through activation of the MAPK/ERK pathway, upregulating Snail and decreasing OVOL2 expression, thereby promoting migration and adhesion of HB cells. POSTN overexpression in HB cell lines, Western blot for ERK pathway and EMT markers, chemotaxis and cell-matrix adhesion assays Cancer biology & medicine Low 31119049
2014 Periostin activates NF-κB signaling in epithelial cells and fibroblasts, constituting an epithelial/mesenchymal interaction important for chronic allergic inflammation in asthma and atopic dermatitis. Summarized from review citing original experimental work on NF-κB activation by periostin in fibroblasts and epithelial cells Cellular and molecular life sciences : CMLS Low 28887633
2020 Periostin secreted by glioblastoma stem cells (GSCs) activates αVβ3 integrin to stimulate PI3K/AKT/β-catenin/FOSL1 pathway, promoting GSC self-renewal and tumor growth; additionally, GSC-derived periostin recruits microglia and upregulates CD70 on microglia via the αVβ3/PI3K/AKT/NF-κB pathway, driving Treg development and immunosuppression. POSTN depletion in GSCs, tumorsphere formation assays, ChIP-seq/ChIP-PCR for β-catenin binding to FOSL1 promoter, Transwell migration, T cell functional assays, patient-derived xenograft and orthotopic mouse models Journal of experimental & clinical cancer research : CR High 39227950
2023 Hyperglycemia stimulates periostin expression in cardiac fibroblasts via TGF-β/Smad signaling; periostin upregulates NAP1L2, which recruits SIRT3 to deacetylate H3K27ac on the promoters of BCAA catabolism enzymes BCAT2 and PP2Cm, impairing BCAA catabolism and contributing to diabetic cardiomyopathy. RNA sequencing, gain/loss-of-function in diabetic mice and cardiac fibroblasts, TGF-β/Smad pathway inhibition, chromatin immunoprecipitation for H3K27ac, BCAT2/PP2Cm expression analysis, glucosyringic acid periostin inhibition Cellular & molecular biology letters Medium 37993768
2004 Periostin acts as a cell adhesion molecule in cardiac development by binding to cell surface integrins; its expression is induced by TGF-beta and bone morphogenetic protein stimulation and is localized to developing ventricular trabeculae endothelium, outflow tract, and atrioventricular endocardial cushions. Northern analysis, whole mount and section in situ hybridization in chicken cardiac development, cloning of chicken periostin ortholog The anatomical record Medium 15532025
2014 Periostin is required for maximal airway hyperresponsiveness and inflammation after house dust mite (HDM) sensitization; periostin on dendritic cells is required for maximal T-cell proliferation and IL-13 responses, and adoptive transfer of WT bone marrow-derived DCs restores allergic responses in periostin-null mice. Postn-/- mice, HDM sensitization/challenge model, periostin neutralizing antibody (OC-20) in C57BL/6 mice, DC adoptive transfer, T cell co-culture with DCs, airway responsiveness measurement The Journal of allergy and clinical immunology High 24996263
2017 siRNA and antisense oligonucleotides against periostin administered intranasally reduce periostin, TGF-β1, collagen deposition, and lung fibrosis scores in bleomycin-induced pulmonary fibrosis mice, establishing periostin as a functional driver of lung fibrosis. Intranasal siRNA and antisense oligonucleotide delivery in bleomycin fibrosis mouse model, measurement of periostin, TGF-β1, collagen in airway fluid and tissue Gene therapy Medium 28820502
2025 PIEZO1 is highly expressed in periostin+ (Postn+) pulmonary myofibroblasts and mediates mechanosensation for myofibroblast activation; conditional deletion of Piezo1 in Postn+ cells disrupts actin organization and prevents YAP/TAZ nuclear localization, shifting myofibroblasts to an apoptotic state and inhibiting lung fibrosis; myofibroblast-specific Yap/Taz deletion fully recapitulates Piezo1-KO protective phenotype. Postn-CreERT2 lineage tracing, conditional Piezo1 KO in Postn+ cells, Yap/Taz conditional KO, bleomycin fibrosis model, actin organization and YAP/TAZ nuclear localization assays The Journal of clinical investigation High 40454481

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 The role of periostin in tissue remodeling across health and disease. Cellular and molecular life sciences : CMLS 334 24146092
2009 The multifaceted role of periostin in tumorigenesis. Cellular and molecular life sciences : CMLS 280 19308325
2009 Origin of cardiac fibroblasts and the role of periostin. Circulation research 238 19893021
2014 Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix biology : journal of the International Society for Matrix Biology 160 24813586
2012 The multiple facets of periostin in bone metabolism. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 157 22310955
2004 Expression and function of periostin-isoforms in bone. Journal of cellular biochemistry 157 15258926
2016 Roles of Periostin in Respiratory Disorders. American journal of respiratory and critical care medicine 145 26756066
2006 Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. British journal of cancer 144 17060937
2007 Periostin: novel diagnostic and therapeutic target for cancer. Histology and histopathology 141 17616943
2017 Periostin in inflammation and allergy. Cellular and molecular life sciences : CMLS 122 28887633
2017 The role of periostin in lung fibrosis and airway remodeling. Cellular and molecular life sciences : CMLS 116 28918442
2014 Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα. The Journal of clinical investigation 114 25003192
2020 Stromal POSTN induced by TGF-β1 facilitates the migration and invasion of ovarian cancer. Gynecologic oncology 101 33317907
2017 Periostin in cardiovascular disease and development: a tale of two distinct roles. Basic research in cardiology 96 29101484
2016 Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis. Mucosal immunology 94 27435108
2022 Periostin: biology and function in cancer. Cancer cell international 89 36224629
2000 Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells. The Journal of biological chemistry 89 10884377
2021 Periostin in Allergy and Inflammation. Frontiers in immunology 85 34512647
2024 POSTN+ cancer-associated fibroblasts determine the efficacy of immunotherapy in hepatocellular carcinoma. Journal for immunotherapy of cancer 80 39067872
2015 Periostin: its role in asthma and its potential as a diagnostic or therapeutic target. Respiratory research 80 25981515
2023 Single-cell and spatial transcriptomics reveal POSTN+ cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer. Clinical and translational medicine 78 38115703
2019 Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI. Journal of the American Society of Nephrology : JASN 72 31690575
2014 Matricellular protein periostin contributes to hepatic inflammation and fibrosis. The American journal of pathology 72 25541330
2010 TGF-ß1 and FAK regulate periostin expression in PDL fibroblasts. Journal of dental research 70 20940356
2015 Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring. Experimental dermatology 67 25421393
2014 PERIOSTIN: role in formation and maintenance of dental tissues. Journal of cellular physiology 66 23702840
2015 Expression and pathological effects of periostin in human osteoarthritis cartilage. BMC musculoskeletal disorders 65 26289167
2014 Periostin is required for maximal airways inflammation and hyperresponsiveness in mice. The Journal of allergy and clinical immunology 65 24996263
2004 Identification and detection of the periostin gene in cardiac development. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 62 15532025
2014 Periostin in skin tissue and skin-related diseases. Allergology international : official journal of the Japanese Society of Allergology 60 24759560
2017 The multifaceted role of periostin in priming the tumor microenvironments for tumor progression. Cellular and molecular life sciences : CMLS 59 28884337
2017 Introductory review: periostin-gene and protein structure. Cellular and molecular life sciences : CMLS 57 28884327
2017 Functions of Periostin in dental tissues and its role in periodontal tissues' regeneration. Cellular and molecular life sciences : CMLS 52 28889194
2015 The role of periostin in neoplastic processes. Folia histochemica et cytobiologica 52 26150285
2020 Periostin: A Potential Therapeutic Target For Pulmonary Hypertension? Circulation research 51 32752980
2012 Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer. PloS one 51 22952986
2015 Mechanical Force-induced TGFB1 Increases Expression of SOST/POSTN by hPDL Cells. Journal of dental research 48 25870205
2014 Expressions and roles of periostin in otolaryngological diseases. Allergology international : official journal of the Japanese Society of Allergology 48 24759558
2014 Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis. The Journal of biological chemistry 47 24469446
2019 Highly Polyvalent DNA Motors Generate 100+ pN of Force via Autochemophoresis. Nano letters 46 31402671
2022 The Role of Periostin in Angiogenesis and Lymphangiogenesis in Tumors. Cancers 45 36077762
2016 Role of Periostin in Adhesion and Migration of Bone Remodeling Cells. PloS one 44 26809067
2019 Periostin in Bone Regeneration. Advances in experimental medicine and biology 40 31037624
2014 Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications. Experimental and molecular pathology 38 25446840
2024 Single-Cell RNA Sequencing Reveals Dysregulated POSTN+WNT5A+ Fibroblast Subclusters in Prurigo Nodularis. The Journal of investigative dermatology 35 38246584
2007 Expression of periostin and its clinicopathological relevance in gastric cancer. World journal of gastroenterology 35 17876898
2022 Integrated Analysis Reveals the Gut Microbial Metabolite TMAO Promotes Inflammatory Hepatocellular Carcinoma by Upregulating POSTN. Frontiers in cell and developmental biology 34 35676936
2019 Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 30991832
2015 Role of pancreatic stellate cells and periostin in pancreatic cancer progression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 32 25840689
2019 Ability of Periostin as a New Biomarker of Idiopathic Pulmonary Fibrosis. Advances in experimental medicine and biology 31 31037627
2015 Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis. World journal of gastroenterology 31 25759527
2015 Elevated expression of periostin in diabetic cardiomyopathy and the effect of valsartan. BMC cardiovascular disorders 31 26281830
2017 Experimental Inhibition of Periostin Attenuates Kidney Fibrosis. American journal of nephrology 30 29268247
2021 An exosomal-carried short periostin isoform induces cardiomyocyte proliferation. Theranostics 29 33897872
2020 Periostin interaction with discoidin domain receptor-1 (DDR1) promotes cartilage degeneration. PloS one 29 32330138
2020 Periostin and matrix stiffness combine to regulate myofibroblast differentiation and fibronectin synthesis during palatal healing. Matrix biology : journal of the International Society for Matrix Biology 29 32777343
2020 Role of serum periostin in the management of asthma and its comorbidities. Respiratory investigation 27 32205146
2019 Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma. Cancer biology & medicine 27 31119049
2019 The Multiaspect Functions of Periostin in Tumor Progression. Advances in experimental medicine and biology 25 31037631
2017 Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis. Gene therapy 25 28820502
2012 P-N bond protein phosphatases. Biochimica et biophysica acta 25 22450136
2020 Periostin Is Expressed by Pericytes and Is Crucial for Angiogenesis in Glioma. Journal of neuropathology and experimental neurology 24 32647861
2019 Periostin in the Kidney. Advances in experimental medicine and biology 23 31037629
2023 Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis. Cellular & molecular biology letters 22 37993768
2022 Soluble POSTN is a novel biomarker complementing CA153 and CEA for breast cancer diagnosis and metastasis prediction. BMC cancer 22 35831854
2019 MicroRNA-98-HMGA2-POSTN signal pathway reverses epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 22 31207579
2024 Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis. The Journal of investigative dermatology 21 38218364
2022 HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression. Frontiers in cell and developmental biology 21 35252198
2022 The Multiple Roles of Periostin in Non-Neoplastic Disease. Cells 21 36611844
2019 Plasma Periostin and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 21 30635868
2019 Periostin and Integrin Signaling in Stem Cell Regulation. Advances in experimental medicine and biology 21 31037634
2020 Knockdown of POSTN Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells From Patients With Steroid-Induced Osteonecrosis. Frontiers in cell and developmental biology 20 33409280
2017 Influence of Periostin on Synoviocytes in Knee Osteoarthritis. In vivo (Athens, Greece) 20 28064223
2015 Promotion of periostin expression contributes to the migration of Schwann cells. Journal of cell science 20 26187852
2020 Periostin Mediates Condylar Resorption via the NF-κB-ADAMTS5 Pathway. Inflammation 19 31840212
2019 Functions of Periostin in Dental Tissues and Its Role in Periodontal Tissue Regeneration. Advances in experimental medicine and biology 19 31037625
2022 Periostin: A Potential Biomarker and Therapeutic Target in Pulmonary Diseases. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 18 35379385
2020 Role of COL3A1 and POSTN on Pathologic Stages of Esophageal Cancer. Technology in cancer research & treatment 18 33280513
2019 Roles of Periostin in Asthma. Advances in experimental medicine and biology 18 31037633
2025 PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. The Journal of clinical investigation 17 40454481
2024 The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma. Journal of experimental & clinical cancer research : CR 17 39227950
2020 miR-876 Inhibits EMT and Liver Fibrosis via POSTN to Suppress Metastasis in Hepatocellular Carcinoma. BioMed research international 17 33083453
2018 Expression and clinical significance of periostin in oral lichen planus. Experimental and therapeutic medicine 17 29805541
2019 Involvement of Periostin in Skin Function and the Pathogenesis of Skin Diseases. Advances in experimental medicine and biology 16 31037628
2019 Practical Application of Periostin as a Biomarker for Pathological Conditions. Advances in experimental medicine and biology 16 31037636
2018 Constitutive overexpression of periostin delays wound healing in mouse skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 16 29418037
2015 Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps. DNA and cell biology 15 25674935
2023 The role of periostin in cardiac fibrosis. Heart failure reviews 14 37870704
2020 FAM20C directly binds to and phosphorylates Periostin. Scientific reports 14 33051588
2017 Periostin in vitreoretinal diseases. Cellular and molecular life sciences : CMLS 14 28913545
2017 Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix biology : journal of the International Society for Matrix Biology 14 28965986
2015 Expression of Periostin in Normal, Atopic, and Nonatopic Chronically Inflamed Canine Skin. Veterinary pathology 14 25755133
2024 Identification of Postn+ periosteal progenitor cells with bone regenerative potential. JCI insight 13 39377227
2020 Effect of periostin silencing on Runx2, RANKL and OPG expression in osteoblasts. Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie 13 33141273
2010 Periostin expression distinguishes between light and dark hypertrophic chondrocytes. The international journal of biochemistry & cell biology 13 20083223
2021 MicroRNA-489-3p promotes adipogenesis by targeting the Postn gene in 3T3-L1 preadipocytes. Life sciences 12 34004251
2020 Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer. Translational oncology 12 32416542
2019 Role of Periostin in Cardiac Valve Development. Advances in experimental medicine and biology 12 31037635
2015 The expression of periostin in dental pulp cells. Archives of oral biology 12 25757150
2021 The role of periostin in kidney diseases. Central-European journal of immunology 11 35125949