Affinage

PHF12

PHD finger protein 12 · UniProt Q96QT6

Length
1004 aa
Mass
109.7 kDa
Annotated
2026-04-28
82 papers in source corpus 9 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PHF12 (Pf1) is a PHD zinc finger scaffold protein that nucleates the Rpd3S/Sin3S chromatin-modifying complex by bridging the mSin3A/B-HDAC corepressor to MRG15 and TLE corepressors, thereby coupling histone deacetylation to transcriptional repression. PHF12 engages mSin3A through two independent SIN3 interaction domains (SID1–PAH2 and SID2–PAH1), while separately binding MRG15 and TLE; its PHD1 finger recognizes unmodified H3K4 with low affinity, and a C-terminal polybasic region binds PI(3)P, together enabling bivalent chromatin targeting in concert with MRG15's H3K36me2/3-reading chromodomain (PMID:11390640, PMID:12391155, PMID:22728643, PMID:16893883). Genetic ablation in mice reveals that PHF12 is essential for embryonic viability, nucleolar integrity, ribosome biogenesis, and prevention of premature cellular senescence (PMID:27956701). PHF12 also transcriptionally activates HDAC1 to promote EGFR/AKT signaling in NSCLC, and its SIN3A-bridging function maintains stem cell and EMT gene programs in triple-negative breast cancer through KLF9-dependent integrin regulation (PMID:39075515, PMID:26460951, PMID:34968869).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2001 High

    Identifying PHF12 as a scaffold linking mSin3A-HDAC and TLE corepressor complexes established it as a previously unknown node connecting two major transcriptional repression machineries.

    Evidence Co-IP, Gal4-fusion repression assays, and domain mapping/mutagenesis in mammalian cells

    PMID:11390640

    Open questions at the time
    • Genomic targets of PHF12-dependent repression unknown
    • Physiological role in vivo untested
    • Structural basis of SID–PAH interactions not resolved
  2. 2002 High

    Demonstrating that PHF12 independently binds MRG15 (but not MRGX or MORF4) and forms a ternary MRG15/Pf1/mSin3A complex revealed how PHF12 bridges distinct chromatin-reading and histone-modifying activities within a single complex.

    Evidence Co-IP, luciferase reporter assays with Gal4-MRG fusions, dominant-negative TLE, domain mapping

    PMID:12391155

    Open questions at the time
    • How PHF12 itself recognizes chromatin was unresolved
    • Competition between MRG15 and mSin3A for overlapping PHF12 regions not yet characterized structurally
  3. 2006 High

    Discovering that the polybasic region C-terminal to PHD1 binds PI(3)P identified a lipid-binding module within PHF12, raising the possibility of membrane or lipid-mediated chromatin targeting.

    Evidence Lipid-binding assays with purified PHD domains and polybasic-region swap experiments in vitro

    PMID:16893883

    Open questions at the time
    • Functional significance of PI(3)P binding in a chromatin context untested
    • Whether lipid binding and histone binding by PHD1 are mutually exclusive was unknown
  4. 2011 High

    Solving the NMR structure of mSin3A-PAH2 bound to PHF12-SID1 and showing that MRG15 competes with PAH2 for the same PHF12 segment revealed an internal regulatory switch within the Rpd3S/Sin3S complex.

    Evidence NMR solution structure, binding competition assays, mutagenesis

    PMID:21440557

    Open questions at the time
    • Functional consequence of MRG15–Sin3A competition on chromatin in cells not addressed
    • Full-length complex architecture unresolved
  5. 2012 High

    Quantifying that PHD1 reads unmodified H3K4 and that both PHF12-PHD1 and MRG15-chromodomain bind their histone marks with >100 µM affinity established that bivalent, not cooperative, recognition is the chromatin-targeting mechanism of the Rpd3S/Sin3S complex.

    Evidence Fluorescence polarization, histone peptide arrays, NMR, pulldowns with modified histone peptides

    PMID:22728643

    Open questions at the time
    • Bivalent targeting model not validated on nucleosomal substrates or in living cells
    • Contribution of PI(3)P binding to overall chromatin association not integrated
  6. 2015 Medium

    Showing that disruption of the SIN3A–PHF12 interface blocks TNBC stem cell maintenance and EMT in vitro and in vivo linked the scaffold's corepressor-bridging function to a specific cancer phenotype.

    Evidence Competitive Tat-SID peptide, PHF12 shRNA, proliferation/invasion assays, xenograft model

    PMID:26460951

    Open questions at the time
    • Direct target genes mediating the phenotype were not identified in this study
    • Mechanism inferred from loss-of-function without reconstitution of the repression complex on specific loci
  7. 2017 High

    Genetic knockout in mice demonstrated that PHF12 is essential for embryonic viability, nucleolar integrity, and ribosome biogenesis, broadening its role from a generic corepressor scaffold to a regulator of fundamental biosynthetic processes and cellular senescence.

    Evidence Pf1 knockout mice, BrdU incorporation, SA-β-Gal, γ-H2AX, RNA-seq, nucleolar morphology, proteomic interactome

    PMID:27956701

    Open questions at the time
    • How PHF12 mechanistically controls nucleolar structure is unknown
    • Whether ribosome biogenesis defect is a direct or indirect consequence of derepression remains unclear
  8. 2021 Medium

    Placing PHF12 upstream of KLF9-mediated repression of ITGA6/ITGB1 in TNBC provided a defined transcriptional pathway through which the SIN3A–PHF12 complex sustains invasive behavior.

    Evidence ChIP for SIN3A and KLF9 on integrin promoters, RNA-seq, KLF9 knockdown rescue

    PMID:34968869

    Open questions at the time
    • Whether PHF12 directly occupies integrin promoters was not shown
    • Generalizability beyond TNBC cell lines not tested
  9. 2024 Medium

    Identifying HDAC1 as a direct transcriptional target of PHF12 that mediates EGFR/AKT activation in NSCLC revealed a feed-forward circuit in which PHF12 both scaffolds and transcriptionally upregulates HDAC1.

    Evidence ChIP of PHF12 at HDAC1 promoter, knockdown/overexpression rescue, xenograft

    PMID:39075515

    Open questions at the time
    • Whether PHF12 acts as an activator at the HDAC1 promoter independently of mSin3A is unknown
    • Single-lab finding; not yet replicated independently

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PHF12 coordinates its multiple binding interfaces (mSin3A, MRG15, TLE, H3K4me0, PI(3)P) on native chromatin, and whether it partitions into functionally distinct sub-complexes at specific genomic loci, remains unresolved.
  • No genome-wide occupancy map for PHF12 itself
  • Full reconstitution of the multi-valent complex on nucleosomes not achieved
  • Contribution of PI(3)P binding to in vivo function untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 2 GO:0140110 transcription regulator activity 2 GO:0008289 lipid binding 1 GO:0042393 histone binding 1
Localization
GO:0005634 nucleus 2 GO:0005694 chromosome 1 GO:0005730 nucleolus 1
Pathway
R-HSA-4839726 Chromatin organization 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-162582 Signal Transduction 1
Partners
HDAC1KLF9MRG15SIN3ASIN3BTLE1
Complex memberships
Rpd3S/Sin3S complexmSin3A-HDAC corepressor complex

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 PHF12 (Pf1) was identified as a novel PHD zinc finger protein that associates with mSin3A in vivo and recruits the mSin3A-HDAC corepressor complex to repress transcription. Pf1 interacts with mSin3A through two independent Sin3 interaction domains (SIDs): Pf1SID1 binds PAH2 and Pf1SID2 binds PAH1. Pf1 also independently interacts with the TLE corepressor (mammalian Groucho homolog) to recruit functional TLE complexes. Co-immunoprecipitation, Gal4-fusion transcription repression assays, domain mapping/mutagenesis, GST pulldowns Molecular and cellular biology High 11390640
2002 PHF12 (Pf1) bridges two global corepressor networks: it interacts with MRG15 (but not MRGX or MORF4) independently of mSin3A, and has independent binding sites for MRG15 and mSin3A. Pf1 reduced transcriptional repression by Gal4-MRG15 but had no effect on MRGX or MORF4. Pf1 and MRG15 bind different domains on mSin3A, forming an MRG15/Pf1/mSin3A complex with distinct functions. Co-immunoprecipitation, Gal4-fusion luciferase reporter assays, dominant-negative TLE, domain mapping Molecular and cellular biology High 12391155
2006 The PHD1 domain of PHF12 (Pf1), but not PHD2, binds phosphoinositides, most strongly PI(3)P. A polybasic region immediately C-terminal to PHD1 is necessary and sufficient for PI(3)P binding, and this polybasic region is a strong determinant of PI binding specificity, establishing it as a phosphoinositide-binding module. Lipid-binding assays with purified PHD domains, maltose-binding protein fusions, isolated peptides; polybasic region exchange experiments The Journal of biological chemistry High 16893883
2011 The NMR solution structure of the mSin3A PAH2 domain bound to the Pf1 SID1 motif shows structural similarity to the Mad1/Mxd1-Sin3 interaction. Residues immediately C-terminal to SID1 are not important for Sin3 PAH2 binding. Unexpectedly, MRG15 competes with Sin3 PAH2 for the same Pf1 segment, implying competition between two subunits of the same Rpd3S/Sin3S complex for Pf1. NMR structure determination, binding assays, mutagenesis, competition experiments Journal of molecular biology High 21440557
2012 PHF12 (Pf1) PHD1 binds preferentially to the unmodified extreme N-terminus of histone H3 (H3K4me0) but not to H3K4me2/3. Both MRG15 chromodomain and Pf1 PHD1 bind their respective histone targets with >100 µM affinity, requiring bivalency (not cooperativity) for chromatin targeting of the Rpd3S/Sin3S complex. Pf1 PHD1 also engages the MRG15 MRG domain in a manner dependent on the Pf1 MRG-binding domain. Fluorescence polarization binding assays, NMR, pull-down assays, histone peptide arrays Journal of molecular biology High 22728643
2017 PHF12 (Pf1/Phf12) is required for mid-to-late gestation viability in mice. Loss of Pf1 in mouse embryonic fibroblasts impairs proliferative potential, induces premature cellular senescence (elevated SA-β-Gal, γ-H2AX), disrupts ribosome biogenesis gene expression, and causes abnormal nucleolar structure. Proteomic analysis of Pf1-interacting complexes revealed proteins involved in ribosome biogenesis, expanding the known functions of the Pf1-associated chromatin complex (MRG15, Sin3B, HDAC1). Pf1 knockout mice, BrdU incorporation, SA-β-Gal assay, γ-H2AX immunostaining, RNA-seq, nucleolar morphology analysis, proteomic interactome Molecular and cellular biology High 27956701
2015 Disruption of the SIN3A-PF1 interaction (via competitive Tat-SID peptide) blocks the TNBC stem cell phenotype and epithelial-to-mesenchymal transition (EMT). Knockdown of PF1 phenocopies Tat-SID treatment in vitro and in vivo (reduced primary tumor growth and metastasis), demonstrating that a SIN3A-PF1 complex is required for maintenance of TNBC stem cell and EMT gene expression. Tat-SID competitive peptide, PF1 shRNA knockdown, in vitro proliferation/invasion assays, xenograft mouse model Oncotarget Medium 26460951
2021 Disruption of PF1/SIN3A interaction (via PF1-SID peptide) inhibits invasion and migration in TNBC by downregulating integrins ITGA6 and ITGB1 through KLF9-mediated transcriptional repression; knockdown of KLF9 restores ITGA6/ITGB1 expression and invasive phenotype, placing PHF12 upstream of KLF9 in this pathway. PF1-SID peptide/transcript expression, RNA-seq, ChIP assay (SIN3A and KLF9 on ITGA6/ITGB1 promoters), KLF9 knockdown rescue experiments Translational oncology Medium 34968869
2024 PHF12 transcriptionally regulates HDAC1 expression (at both mRNA and protein levels) and the PHF12-HDAC1 axis activates the EGFR/AKT signaling pathway to promote NSCLC proliferation and migration; HDAC1 overexpression rescues the proliferation defect caused by PHF12 knockdown. ChIP assay (PHF12 binding at HDAC1 promoter), PHF12 knockdown/overexpression, HDAC1 overexpression rescue, RNA-seq/GSEA, xenograft model Journal of translational medicine Medium 39075515

Source papers

Stage 0 corpus · 82 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1983 Structure similarity, difference and variability in the filamentous viruses fd, If1, IKe, Pf1 and Xf. Investigation by laser Raman spectroscopy. Journal of molecular biology 135 6405045
1991 NMR studies of the structure and dynamics of membrane-bound bacteriophage Pf1 coat protein. Science (New York, N.Y.) 121 1925542
2011 Chemical shifts for the unusual DNA structure in Pf1 bacteriophage from dynamic-nuclear-polarization-enhanced solid-state NMR spectroscopy. Journal of the American Chemical Society 84 21854063
2007 Filamentous phage studied by magic-angle spinning NMR: resonance assignment and secondary structure of the coat protein in Pf1. Journal of the American Chemical Society 83 17279748
2002 Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Molecular and cellular biology 83 12391155
1983 Comparison of protein and deoxyribonucleic acid backbone structures in fd and Pf1 bacteriophages. Biochemistry 82 6340725
2004 Structure of the coat protein in Pf1 bacteriophage determined by solid-state NMR spectroscopy. Journal of molecular biology 81 15288792
2008 Conformational dynamics of an intact virus: order parameters for the coat protein of Pf1 bacteriophage. Proceedings of the National Academy of Sciences of the United States of America 79 18653759
1991 DNA sequence of the filamentous bacteriophage Pf1. Journal of molecular biology 79 2010913
1986 The ionic properties of the filamentous bacteriophages Pf1 and fd. The Journal of biological chemistry 77 3944103
1994 Pf1 virus structure: helical coat protein and DNA with paraxial phosphates. Science (New York, N.Y.) 75 8036516
2001 Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. Molecular and cellular biology 71 11390640
2006 The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. The Journal of biological chemistry 66 16893883
2010 Structure and dynamics of the membrane-bound form of Pf1 coat protein: implications of structural rearrangement for virus assembly. Biophysical journal 58 20816058
1991 Membrane-mediated assembly of filamentous bacteriophage Pf1 coat protein. Science (New York, N.Y.) 52 1925543
1975 Structure of coat proteins in Pf1 and fd virions by laser raman spectroscopy. Science (New York, N.Y.) 52 1170637
1994 PF1: an A-T hook-containing DNA binding protein from rice that interacts with a functionally defined d(AT)-rich element in the oat phytochrome A3 gene promoter. The Plant cell 51 8148649
2000 Intensity of the polarized Raman band at 1340-1345 cm-1 as an indicator of protein alpha-helix orientation: application to Pf1 filamentous virus. Biochemistry 43 10704218
1979 Macromolecular structural transitions in Pf1 filamentous bacterial virus. Nature 41 481592
1987 Structure and dynamics of the Pf1 filamentous bacteriophage coat protein in micelles. Biochemistry 40 3567175
1999 Demonstration by ultraviolet resonance Raman spectroscopy of differences in DNA organization and interactions in filamentous viruses Pf1 and fd. Biochemistry 39 10074370
2000 The molecular structure and structural transition of the alpha-helical capsid in filamentous bacteriophage Pf1. Acta crystallographica. Section D, Biological crystallography 36 10666593
1995 Pf1 filamentous bacteriophage: refinement of a molecular model by simulated annealing using 3.3 A resolution X-ray fibre diffraction data. Acta crystallographica. Section D, Biological crystallography 35 15299811
1989 A CD determination of the alpha-helix contents of the coat proteins of four filamentous bacteriophages: fd, IKe, Pf1, and Pf3. Biopolymers 35 2597737
2005 Structural basis of the temperature transition of Pf1 bacteriophage. Protein science : a publication of the Protein Society 34 15741342
1994 Ultraviolet absorbance and circular dichroism of Pf1 virus: nucleotide/subunit ratio of unity, hyperchromic tyrosines and DNA bases, and high helicity in the subunits. Biochemistry 33 8110771
1987 Pf1 Inovirus. Electron density distribution calculated by a maximum entropy algorithm from native fibre diffraction data to 3 A resolution and single isomorphous replacement data to 5 A resolution. Journal of molecular biology 33 3599076
1983 Silver and mercury probing of deoxyribonucleic acid structures in the filamentous viruses fd, If1, IKe, Xf, Pf1, and Pf3. Biochemistry 33 6354268
1983 Maximum-entropy calculation of the electron density at 4 A resolution of Pf1 filamentous bacteriophage. Proceedings of the National Academy of Sciences of the United States of America 32 6410396
1982 The DNA-binding protein of Pf1 filamentous bacteriophage: amino-acid sequence and structure of the gene. The EMBO journal 32 16453414
1982 DNA packing in the filamentous viruses fd, Xf, Pf1 and Pf3. Nucleic acids research 31 6806774
1991 Neutron diffraction studies of the structure of filamentous bacteriophage Pf1. Demonstration that the coat protein consists of a pair of alpha-helices with an intervening, non-helical surface loop. Journal of molecular biology 30 1906942
1988 Sugar pucker and phosphodiester conformations in viral genomes of filamentous bacteriophages: fd, If1, IKe, Pf1, Xf, and Pf3. Biochemistry 29 3166982
2011 Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex. Journal of molecular biology 28 21440557
2015 Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer. Oncotarget 26 26460951
2003 Protein and DNA residue orientations in the filamentous virus Pf1 determined by polarized Raman and polarized FTIR spectroscopy. Biochemistry 26 12549913
1999 The HMG-I/Y protein PF1 stimulates binding of the transcriptional activator GT-2 to the PHYA gene promoter. The Plant journal : for cell and molecular biology 26 10363369
1995 A Monte Carlo model of fd and Pf1 coat proteins in lipid membranes. Biophysical journal 26 8534808
1995 The effect of the nematode peptides SDPNFLRFamide (PF1) and SADPNFLRFamide (PF2) on synaptic transmission in the parasitic nematode Ascaris suum. Parasitology 25 7753584
1993 Evaluation of transmembrane helix prediction methods using the recently defined NMR structures of the coat proteins from bacteriophages M13 and Pf1. Biochimica et biophysica acta 24 8373820
2012 Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. Journal of molecular biology 23 22728643
2014 Pf1 bacteriophage hydration by magic angle spinning solid-state NMR. The Journal of chemical physics 21 25494804
2002 Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle. International journal for parasitology 21 12464423
1988 Conformation of the coat protein of filamentous bacteriophage Pf1 determined by neutron diffraction from magnetically oriented gels of specifically deuterated virions. Journal of molecular biology 21 3127590
2015 Purification and Characterization of a Fucoidanase (FNase S) from a Marine Bacterium Sphingomonas paucimobilis PF-1. Marine drugs 19 26193285
2010 A structural model for the single-stranded DNA genome of filamentous bacteriophage Pf1. Biochemistry 18 20078135
1991 Circular dichroism and fluorescence analysis of the interaction of Pf1 gene 5 protein with poly(dT). Journal of molecular biology 18 2005618
1985 Time-resolved fluorescence of bacteriophage Pf1 DNA-binding protein. Determination of oligonucleotide and polynucleotide binding parameters. European journal of biochemistry 18 4039662
2013 NMR-based simulation studies of Pf1 coat protein in explicit membranes. Biophysical journal 17 23931317
2004 Effects of virion and salt concentrations on the Raman signatures of filamentous phages fd, Pf1, Pf3, and PH75. Biochemistry 17 15476406
1998 Analysis of X-ray diffraction from fibres of Pf1 Inovirus (filamentous bacteriophage) shows that the DNA in the virion is not highly ordered. Journal of molecular biology 17 9878347
2017 The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence. Molecular and cellular biology 16 27956701
2021 Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A-PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1. Translational oncology 15 34968869
1988 Raman spectroscopy of mercury (II) binding to two filamentous viruses: Ff (fd, M13, f1) and Pf1. Biochemistry 15 3280025
2021 Biodegradation of organophosphorus pesticide profenofos by the bacterium Bacillus sp. PF1 and elucidation of initial degradation pathway. Environmental technology 14 34469281
2016 Small Colony Variants and Single Nucleotide Variations in Pf1 Region of PB1 Phage-Resistant Pseudomonas aeruginosa. Frontiers in microbiology 14 27014207
2010 Simultaneous structure and dynamics of a membrane protein using REDCRAFT: membrane-bound form of Pf1 coat protein. Journal of magnetic resonance (San Diego, Calif. : 1997) 14 20829084
1995 FT-IR spectroscopy of the major coat protein of M13 and Pf1 in the phage and reconstituted into phospholipid systems. Biochemistry 14 7794893
1993 Biophysical studies of the Pf1 coat protein in the filamentous phage, in detergent micelles, and in a membrane environment. Biochemistry 14 8399218
1991 The role of tyrosine residues in the DNA-binding site of the Pf1 gene 5 protein. Protein engineering 14 1891463
1987 Structural responsiveness of filamentous bacteriophage Pf1: comparison of virion structure in fibers and solution. The effect of temperature and ionic strength. Biophysical journal 14 3663828
1985 Natural killer (NK) cells and graft-versus-host disease (GVHD): no correlation between the NK cell levels and GVHD in the murine P----F1 model. Immunology 14 3972429
2014 Involvement of tumor-associated macrophage activation in vitro during development of a novel mantle cell lymphoma cell line, PF-1, derived from a typical patient with relapsed disease. Leukemia & lymphoma 12 24611650
2000 Pf1 filamentous phage as an alignment tool for generating local and global structural information in nucleic acids. Journal of biomolecular structure & dynamics 12 22607445
1983 Dissociation of the Pf1 nucleoprotein assembly complex and characterisation of the DNA binding protein. Biochimica et biophysica acta 12 6297583
1993 Molecular dynamics simulation of Pf1 coat protein. Biophysical journal 10 8471719
1998 Equilibrium and kinetic binding analysis of the N-terminal domain of the Pf1 gene 5 protein and its interaction with single-stranded DNA. Journal of molecular biology 9 9466922
1985 Identification of lysine residues at the binding site of bacteriophage-Pf1 DNA-binding protein. The Biochemical journal 8 3924033
1999 Conformational studies of the C-terminal domain of bacteriophage Pf1 gene 5 protein. Biochimica et biophysica acta 7 10561545
1995 Comparison of Pf1 and Fd gene 5 proteins and their single-stranded DNA complexes by NMR spectroscopy and differential scanning calorimetry. Biochemistry 7 7819190
1987 Cloning and expression of the filamentous bacteriophage Pf1 major coat protein gene in Escherichia coli. Membrane protein processing and virus assembly. Journal of molecular biology 7 3309343
2021 LncRNA RP11-116G8.5 promotes the progression of lung squamous cell carcinoma through sponging miR-3150b-3p/miR-6870-5p to upregulate PHF12/FOXP4. Pathology, research and practice 6 34500373
1993 Identification of a compact DNA-binding domain in the gene 5 protein of Pf1 bacteriophage. Biochemistry 6 8466905
1988 Thermal difference circular dichroism of Pf1 filamentous virus and effects of mercury(II), silver(I), and copper(II). Biochemistry 6 3136800
1984 Estimation of tyrosine-40-DNA distance in the filamentous phage Pf1 by analysis of its intrinsic fluorescence properties. Biochimica et biophysica acta 5 6477921
1983 Pf1 bacteriophage replication--assembly complex. X-ray fibre diffraction of the high humidity form. Journal of molecular biology 5 6606711
2008 Effects of SDPNFLRF-amide (PF1) on voltage-activated currents in Ascaris suum muscle. International journal for parasitology 4 18760280
1991 Export of infectious particles by Escherichia coli transfected with the RF DNA of Pf1, a virus of Pseudomonas aeruginosa strain K. Molecular microbiology 4 1779755
1994 Cloning and characterization of cDNAs encoding oat PF1: a protein that binds to the PE1 region in the oat phytochrome A3 gene promoter. Biochemical Society symposium 3 7639786
2024 PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT signaling pathway in non-small cell lung cancer. Journal of translational medicine 2 39075515
2004 Line shape analyses for water 17O NMR quintet observed in a bacteriophage Pf1 solution at different temperatures. Biophysical chemistry 2 14967240
1991 Structural parameters of the Pf1 gene 5 protein-DNA complex in solution by neutron scattering. Journal of molecular biology 1 1942028