Affinage

Showing POSTN — PERIOSTIN is a alias.

POSTN

Periostin · UniProt Q15063

Length
836 aa
Mass
93.3 kDa
Annotated
2026-06-10
100 papers in source corpus 33 papers cited in narrative 33 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Periostin (POSTN) is a secreted, N-glycosylated, heparin-binding matricellular protein whose multi-domain architecture (EMI domain, four FAS1 domains, and a C-terminal domain) lets it act as an extracellular scaffold that brings collagens (type I/V), fibronectin, tenascin-C, laminin, lysyl oxidase, BMP-1, CCN3, and Notch1 into proximity to assemble organized matrix architectures (PMID:29086200, PMID:28887577). Beyond structural scaffolding, periostin signals as an integrin ligand: it engages integrin-β1, αvβ3, and the receptor tyrosine kinase DDR1 to activate PI3K/AKT/β-catenin, NF-κB, RhoA, and STAT3-type cascades that drive cellular responses to matrix and mechanical cues (PMID:31690575, PMID:32330138, PMID:33317907, PMID:39227950). A recurring theme is its role in tissue remodeling downstream of TGF-β1/Smad signaling, often induced by mechanical force: periostin is required for myofibroblast differentiation and collagen gel contraction through integrinβ1/RhoA (PMID:32777343), and its deletion protects mice from carbon tetrachloride/bile-duct-ligation liver fibrosis, bleomycin lung fibrosis, and obstructive/diabetic renal fibrosis (PMID:25541330, PMID:28820502, PMID:28819200). In cartilage it signals via DDR1 to activate AKT/β-catenin and via NF-κB to induce MMP-13 and ADAMTS5, degrading collagen and proteoglycan (PMID:32330138, PMID:31840212). Periostin also functions in osteoblast and cardiac development, bone responses to mechanical unloading through a periostin→sclerostin axis (PMID:25445447), and supports tumor progression by remodeling collagen in cancer-associated fibroblasts and signaling to cancer and stromal cells to promote invasion, lymphatic metastasis, glioma stem-cell self-renewal, angiogenesis, and immunosuppression (PMID:33317907, PMID:39227950, PMID:37205636). In injured lung, periostin marks myofibroblasts whose PIEZO1-dependent mechanoactivation drives Yap/Taz-dependent fibrosis (PMID:40454481).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1995 Medium

    Established the basic biochemical nature of the protein, showing periostin is a secreted, N-glycosylated, heparin-binding molecule destined for the bone extracellular matrix.

    Evidence Baculovirus expression with tunicamycin/N-Glycanase glycosylation assays and heparin-binding assay

    PMID:7663166

    Open questions at the time
    • No identification of physiological binding partners in vivo
    • Functional consequence of glycosylation or heparin binding not tested
  2. 2004 Medium

    Linked periostin to specific differentiation and developmental programs, showing it is required for osteoblast differentiation and is spatiotemporally expressed during cardiac morphogenesis.

    Evidence Antisense/antibody loss-of-function in osteoblasts and Northern/in situ hybridization in chick heart

    PMID:15258926 PMID:15532025

    Open questions at the time
    • Molecular mechanism of differentiation control not defined
    • Receptor and signaling pathway not identified
  3. 2007 Medium

    Identified upstream inducers in development, demonstrating BMP-2/BMPR-1B signaling drives periostin expression in cardiac cushion mesenchyme via Twist/Id1.

    Evidence Constitutively-active/dominant-negative viral constructs and noggin in chick AV cushion cells with qRT-PCR

    PMID:18261719

    Open questions at the time
    • Direct promoter binding by Twist/Id1 not shown
    • Downstream periostin function in cushion remodeling not tested here
  4. 2009 Medium

    Showed periostin isoform PLF actively promotes bone formation, extending its role from differentiation marker to functional driver of osteoblast proliferation and fracture healing.

    Evidence Adenoviral overexpression in vitro and intramarrow injection in rat femur with mineralization assays

    PMID:19006175

    Open questions at the time
    • Receptor/signaling mechanism unresolved
    • Isoform-specific functions not dissected
  5. 2011 Medium

    Demonstrated a regulatory role in kidney organogenesis, with periostin inhibiting branching morphogenesis and co-expressing with its αv integrin receptor.

    Evidence Metanephric explant culture with recombinant periostin, qRT-PCR and immunofluorescence co-localization

    PMID:21855915

    Open questions at the time
    • Direct integrin signaling not functionally tested
    • BMP-4 to periostin promoter link not established
  6. 2014 High

    Established periostin as a TGF-β1-induced effector of organ fibrosis and a pro-inflammatory/catabolic signaling ligand, central to its remodeling functions.

    Evidence Postn-knockout mice in CCl4/BDL liver fibrosis; recombinant periostin on chondrocytes with NF-κB inhibition; KO/gain-of-function in pancreatic regeneration and bone unloading

    PMID:25445447 PMID:25485969 PMID:25541330 PMID:26289167

    Open questions at the time
    • Surface receptor in fibrosis not pinned to a single integrin
    • Whether periostin acts on stellate cells autonomously or via collagen scaffolding unclear
  7. 2015 Medium

    Defined a mechanotransduction circuit, showing compressive force induces POSTN through locally retained TGF-β1 rather than soluble signaling.

    Evidence Compressive loading of periodontal ligament fibroblasts with TGF-β inhibitor, neutralizing antibody and cycloheximide

    PMID:25870205

    Open questions at the time
    • Transcription factors mediating force-induced POSTN not identified
    • How matrix-retained TGF-β1 is activated by force unresolved
  8. 2016 Medium

    Identified transcriptional and signaling regulators in cancer, placing POSTN as a direct TAp73 target and a STAT3-activating driver of glioma invasion and anti-angiogenic resistance.

    Evidence ChIP and luciferase reporter for TAp73; recombinant POSTN and xenograft analyses for STAT3/HIF1α/VEGF

    PMID:26930720 PMID:27307601

    Open questions at the time
    • Mechanism of STAT3 activation by POSTN not dissected
    • Receptor mediating glioma effects not defined here
  9. 2017 Medium

    Consolidated the scaffold model and validated periostin as a therapeutic target, with its FAS1 domains organizing matrix proteins and RNA/antibody blockade reducing lung and kidney fibrosis.

    Evidence Domain-binding mapping syntheses; intranasal siRNA/antisense in bleomycin lung fibrosis; anti-periostin antibody, aptamer, and integrin-blockade peptide in renal fibrosis models

    PMID:28819200 PMID:28820502 PMID:28887577 PMID:29086200 PMID:29268247

    Open questions at the time
    • Quantitative stoichiometry of scaffold assembly unknown
    • Specific integrin engaged in each fibrotic tissue not fully resolved
  10. 2018 High

    Positioned periostin upstream of tumor stromal remodeling, showing it drives M2 macrophage and αSMA+ stromal rebound and revascularization after anti-VEGFA therapy.

    Evidence Genetic Postn deletion in RIP1-Tag2 mice with VEGFA blockade and anti-CSF1R macrophage depletion

    PMID:29514082

    Open questions at the time
    • Receptor by which POSTN recruits macrophages not identified
    • Direct vs. matrix-mediated effect on stroma not separated
  11. 2019 High

    Identified specific receptors and binding partners mediating periostin signaling, establishing integrin-β1 in renal repair/macrophage proliferation and tenascin-C as a direct interactor driving pathological angiogenesis.

    Evidence Conditional tubule Postn gain/loss mice with integrin-β1 interaction studies; Co-IP of periostin with tenascin-C plus siRNA and KO retinopathy models

    PMID:30991832 PMID:31690575 PMID:32518264

    Open questions at the time
    • Whether integrin-β1 acts directly on macrophages or tubular cells in each context unclear
    • Isoform-specific functional differences only partly characterized
  12. 2020 High

    Mapped a network of receptors and downstream pathways across tissues, defining DDR1→AKT/β-catenin for cartilage catabolism, integrinβ1/RhoA for myofibroblast contraction, αvβ3/PI3K/Akt for tumor EMT, and feedback loops in angiogenesis, calcification, and autophagy.

    Evidence DDR1 KO chondrocytes; Postn-KO palatal fibroblasts with recombinant rescue and Rac inhibition; CAF αvβ3 co-culture; HIF-1α/TrkB epistasis; NF-κB-ADAMTS5 and autophagy/ROS assays; pericyte 3D angiogenesis

    PMID:31840212 PMID:32330138 PMID:32647861 PMID:32752980 PMID:32777343 PMID:33317907 PMID:33744420

    Open questions at the time
    • Which receptor predominates when multiple are co-expressed not resolved
    • How a single ligand selects divergent downstream pathways in different cells unclear
  13. 2021 High

    Established a complete receptor-to-transcription axis in glioma, showing POSTN drives stem-cell self-renewal via αVβ3/PI3K/AKT/β-catenin/FOSL1 and immunosuppression via NF-κB/CD70.

    Evidence POSTN knockdown, ChIP-seq/ChIP-PCR for β-catenin→FOSL1, tumorsphere and immunosuppression assays, orthotopic and patient-derived xenografts

    PMID:39227950

    Open questions at the time
    • Cellular source of POSTN within the niche not fully assigned
    • Crosstalk between the two bifurcating pathways not explored
  14. 2023 High

    Extended periostin into intracellular metabolic and epigenetic regulation, showing TGF-β/Smad-induced periostin impairs cardiac BCAA catabolism through a NAP1L2/SIRT3/H3K27ac axis, and connecting CAF-derived periostin to collagen-alignment-driven lymphatic metastasis.

    Evidence RNA-seq guided KO/overexpression with H3K27ac ChIP and SIRT3 assays in diabetic cardiomyopathy; in vivo lineage tracing and ablation of periostin+ CAFs with collagen/invasion assays

    PMID:37205636 PMID:37993768

    Open questions at the time
    • How a secreted matrix protein triggers intracellular NAP1L2 induction is mechanistically incomplete
    • Generalizability of the lymphatic-specific metastasis effect to other tumors untested
  15. 2025 High

    Defined the mechanosensing machinery of periostin+ myofibroblasts, placing PIEZO1→Yap/Taz downstream of mechanical activation in lung fibrosis.

    Evidence Postn-Cre conditional Piezo1 and Yap/Taz deletion, cell ablation, actin imaging and bleomycin fibrosis model

    PMID:40454481

    Open questions at the time
    • Whether periostin itself feeds into PIEZO1 activation not tested
    • Relationship between secreted periostin and intracellular mechanotransduction unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unclear how a single matricellular ligand selects among its multiple receptors (integrin-β1, αvβ3, DDR1) and divergent downstream pathways in a cell- and context-specific manner, and how secreted periostin connects to its reported intracellular and mechanosensing functions.
  • No structural model of receptor selectivity
  • No unified accounting of extracellular vs. intracellular periostin actions
  • Isoform-specific receptor preferences undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098772 molecular function regulator activity 3 GO:0005198 structural molecule activity 2 GO:0008289 lipid binding 1
Localization
GO:0031012 extracellular matrix 3 GO:0005576 extracellular region 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-1474244 Extracellular matrix organization 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4
Partners
BMP1DDR1FN1ITGAVITGB1ITGB3NOTCH1TNC

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Recombinant murine OSF-2 (periostin) expressed in baculovirus/insect cells is N-glycosylated (demonstrated by tunicamycin treatment and N-Glycanase digestion causing mobility shifts on Western blot) and binds heparin, suggesting association with bone extracellular matrix after secretion. Baculovirus expression system, Western blot, tunicamycin treatment, N-Glycanase digestion, endoglycosidase H digestion, heparin-binding assay Protein expression and purification Medium 7663166
2004 Periostin isoforms (including periostin-like-factor/PLF) are expressed during osteoblast differentiation stages; antisense oligonucleotides and blocking antibodies directed against periostin isoforms markedly reduced levels of osteoblast-specific differentiation markers, indicating a functional role in osteoblast differentiation. Antisense oligonucleotide knockdown, antibody blockade, Western blot, in situ hybridization Journal of cellular biochemistry Medium 15258926
2004 Periostin (chicken ortholog) is expressed in the developing endothelium of ventricular trabeculae, endothelium and mesenchyme of the outflow tract and atrioventricular endocardial cushions, and in valve leaflets and chordae tendinae during fetal development, establishing spatiotemporal localization during cardiac morphogenesis. Northern analysis, whole mount and section in situ hybridization The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Medium 15532025
2007 BMP-2 signaling through BMPR-1B (ALK6) induces periostin expression at both mRNA and protein levels in atrioventricular cushion mesenchymal cells; conversely, noggin (BMP antagonist) or dominant-negative BMPR-1B represses periostin expression. BMP-2 also induces Twist and Id1 transcripts, which are implicated in periostin promoter activation. 3D collagen gel culture of chick AV cushion mesenchymal cells, constitutively active/dominant-negative viral constructs, qRT-PCR, protein expression analysis Developmental biology Medium 18261719
2009 Periostin-like-factor (PLF), a periostin isoform, promotes osteoblast proliferation and differentiation in vitro, and in vivo injection into rat femur bone marrow increases bone formation; PLF expression is robustly upregulated in callus osteoblasts during fracture healing. Adenoviral overexpression, CyQUANT proliferation assay, alkaline phosphatase staining, von Kossa staining, calcium deposition assay, in vivo intramarrow injection, immunostaining Journal of cellular physiology Medium 19006175
2011 Exogenous periostin inhibits ureteral branching morphogenesis and reduces glomerular number in metanephric explant cultures; BMP-4 upregulates periostin mRNA expression in the developing kidney; periostin and its receptor αv integrin are co-expressed in ureteral smooth muscle cells at E15.5. Metanephric explant culture with recombinant periostin, quantitative RT-PCR, immunofluorescence, RNA in situ hybridization The Journal of urology Medium 21855915
2014 Periostin deficiency in mice abrogates carbon tetrachloride- and bile duct ligation-induced liver fibrosis; TGF-β1 markedly induces periostin expression in primary hepatic stellate cells; periostin co-localizes with hepatic stellate cell-derived collagen I and α-SMA in fibrotic liver; periostin-null mice show reduced α-SMA, fibronectin, collagen I, and pro-inflammatory cytokine levels after CCl4 treatment. Periostin-knockout mice, CCl4 and BDL fibrosis models, immunohistochemistry, qRT-PCR, Western blot, primary hepatic stellate cell culture with TGF-β1 The American journal of pathology High 25541330
2014 Periostin induces expression of IL-6, IL-8, MMP-1, MMP-3, MMP-13, and NOS2 in cultured human chondrocytes in a dose- and time-dependent manner via NF-κB signaling (evidenced by nuclear translocation of p65); NF-κB inactivation suppresses periostin-induced upregulation of these genes. Primary human chondrocyte culture with recombinant periostin, qRT-PCR, NF-κB inhibition (BAY compound), immunocytochemistry of p65 nuclear translocation BMC musculoskeletal disorders Medium 26289167
2014 Periostin promotes pancreatic β-cell regeneration: injection of periostin into the pancreas stimulated proliferation of vimentin-expressing mesenchymal cells and duct-like cells expressing Ngn3 and Pdx1; Postn-deficient mice show impaired mesenchymal formation and reduced β-cell regeneration after partial pancreatectomy and increased sensitivity to streptozotocin. Periostin-knockout mice, partial pancreatectomy model, intraperitoneal and intraductal injection of recombinant periostin, immunostaining, glucose tolerance testing Endocrinology Medium 25485969
2014 Periostin expression contributes to cortical bone loss during unloading: hindlimb suspension decreases Postn expression and consecutively increases Sost (sclerostin) expression; Postn-null mice do not show increased Sost upon unloading and are protected from cortical bone loss, indicating periostin regulates cortical bone response to mechanical forces through a periostin→sclerostin axis. Periostin-knockout mice, hindlimb suspension model, bone microstructure analysis, gene expression analysis (Postn, Sost, Dkk1, Rankl, Opg) Bone Medium 25445447
2015 Mechanical compressive force induces POSTN expression in human periodontal ligament (hPDL) fibroblasts via TGF-β1 signaling: cycloheximide, TGF-β inhibitor (SB431542), or neutralizing antibody against TGF-β1 attenuated force-induced POSTN expression. TGF-β1 accumulated intracellularly/in surrounding matrix (not in medium) upon loading. Computerized cell compressive force loading apparatus, real-time PCR, Western blot, ELISA, pharmacological inhibition (cycloheximide, SB431542), neutralizing antibody Journal of dental research Medium 25870205
2016 TAp73 transcription factor directly activates POSTN expression in glioblastoma cells; chromatin immunoprecipitation and reporter assays demonstrate POSTN is a transcriptional target of TAp73; POSTN overexpression rescues the invasive phenotype of glioblastoma cells after p73 knockdown. siRNA knockdown, chromatin immunoprecipitation (ChIP), luciferase reporter assay, invasion assay, POSTN overexpression rescue experiment Oncotarget Medium 26930720
2016 POSTN in glioma stem cells (GSCs) regulates invasion and expression of EMT markers (caveolin-1) and angiogenesis-related genes (HIF1α, VEGF-A) through activation of STAT3; recombinant POSTN increases GSC invasion; POSTN expression is associated with acquired resistance to anti-VEGF-A therapy in mouse xenograft models. Mouse xenograft models, recombinant POSTN treatment, gene expression analysis, STAT3 pathway analysis Molecular cancer therapeutics Low 27307601
2017 Periostin's multi-domain structure (EMI domain, four FAS1 domains, C-terminal domain) enables binding to type I collagen, fibronectin, tenascin-C, laminin γ2, BMP-1 (which catalyzes crosslinking of type I collagen), proteoglycans, Notch1, and CCN3; adjacent domains put interacting proteins in close proximity, promoting assembly into extracellular matrix architectures. Binding domain mapping studies, literature synthesis of domain-protein interaction data Journal of cell communication and signaling Medium 29086200
2017 Periostin's multi-domain structure functions as a scaffold for assembly of extracellular matrix proteins; adjacent binding sites on periostin bring interacting proteins (collagen type I and V, fibronectin, tenascin, laminin, CCN3, βig-h3, lysyl oxidase, BMP-1) into close proximity, promoting intermolecular interactions and assembly into extracellular architectures. Review of direct binding experiments from multiple studies (domain mapping, pulldown assays) Cellular and molecular life sciences : CMLS Medium 28887577
2017 Oligonucleotide-based periostin inhibition (siRNA and antisense oligonucleotide) administered intranasally reduces pulmonary fibrosis in bleomycin-treated mice, decreasing periostin levels, TGF-β1, collagen deposition, and fibrosis scores. siRNA and antisense oligonucleotide in vivo treatment, bleomycin pulmonary fibrosis model, gene/protein expression analysis, histological fibrosis scoring Gene therapy Medium 28820502
2017 Periostin blockade using an anti-periostin polyclonal antibody attenuates renal fibrosis in the unilateral ureteral obstruction model by altering TGF-β signaling, inflammatory and apoptotic pathways; integrin blockade peptide decreases fibrosis-related gene expression in vitro; recombinant periostin increases α-SMA expression in collecting duct cells. Periostin-knockout mice, UUO model, anti-periostin antibody treatment, integrin blockade peptide, recombinant periostin treatment in primary tubular cells, gene expression analysis American journal of nephrology Medium 29268247
2017 Aptamer-based blockade of periostin (PA) attenuates TGF-β1-induced upregulation of fibronectin and type I collagen in inner medullary collecting duct cells in vitro, and reduces renal fibrosis in diabetic mice in vivo. Periostin-binding DNA aptamer treatment, TGF-β1 stimulation of IMCD cells, qRT-PCR, Western blot, immunohistochemistry, Sirius Red staining in diabetic mouse model Scientific reports Medium 28819200
2018 Genetic deletion of Postn in RIP1-Tag2 mice blunts tumor rebounds of M2-like macrophages and αSMA+ stromal cells after prolonged VEGFA inhibition, suppresses PNET revascularization and progression, and impedes upregulation of FGF2; depleting macrophages with anti-CSF1R antibody similarly inhibits PNET revascularization under VEGFA blockade despite continued POSTN production, placing macrophage recruitment downstream of POSTN. Genetic Postn deletion in RIP1-Tag2 transgenic mice, VEGFA blockade, anti-CSF1R antibody, tumor histology, gene expression analysis Cell reports High 29514082
2019 Periostin interacts with integrin-β1 to inhibit tubular cell cycle arrest and apoptosis after ischemia-reperfusion injury; periostin-overexpressing mice have more F4/80+ macrophages with increased proliferation and proregenerative factor expression; treating macrophages with recombinant periostin directly induces macrophage proliferation and proregenerative molecule expression. Conditional tubule-specific periostin overexpression and knockout mice, renal ischemia-reperfusion injury model, primary tubular cell hypoxia-reoxygenation model, macrophage co-culture with recombinant periostin, integrin-β1 interaction studies Journal of the American Society of Nephrology : JASN High 31690575
2019 Full-length hPOSTN isoform 1 overexpression in chondrosarcoma cells alters expression of genes with known roles in chondrocyte function and osteoarthritis; cells expressing total POSTN (not isoform 1 specifically) exhibited increased cell adhesion potential, suggesting isoform-specific functional differences. Stable transfection with pcDNA3.1-hPOSTN-001, RNA-sequencing, cell adhesion assay, siRNA knockdown FASEB journal : official publication of the Federation of American Societies for Experimental Biology Low 30991832
2019 Periostin interacts with tenascin-C (confirmed by co-immunoprecipitation in human microvascular endothelial cells after IL-13 stimulation); single or dual siRNA inhibition of periostin and tenascin-C suppresses angiogenic functions of endothelial cells; periostin-knockout mice show scant tenascin-C expression and attenuated pathological neovascularization in oxygen-induced retinopathy. Co-immunoprecipitation, siRNA knockdown, in vitro angiogenesis assay, periostin-knockout and tenascin-C-knockout mice, oxygen-induced retinopathy model Scientific reports High 32518264
2020 Periostin interacts with discoidin domain receptor-1 (DDR1), a receptor tyrosine kinase; genetic deficiency or pharmacological inhibition of DDR1 in mouse chondrocytes blocks periostin-induced MMP-13 expression; periostin signals through DDR1 to activate AKT/β-catenin signaling and downstream MMP-13 and ADAMTS4 expression, promoting cartilage collagen and proteoglycan degradation. DDR1 knockout mouse chondrocytes, DDR1 pharmacological inhibitor, Western blot, gene expression analysis, in vitro cartilage degradation assay PloS one Medium 32330138
2020 CAF-derived POSTN functions as a ligand for integrin αvβ3 on ovarian cancer cells, activating the PI3K/Akt pathway and inducing EMT to enhance cancer cell migration and invasion; TGF-β1-mediated activation of fibroblasts partly relies on POSTN. Transwell migration/invasion assay, lentiviral POSTN knockdown and overexpression, RNA sequencing, Western blot, indirect co-culture Gynecologic oncology Medium 33317907
2020 POSTN promotes pulmonary hypertension via a positive feedback loop with HIF-1α: POSTN overexpression activates HIF-1α and increases ET-1 and VEGF production in pulmonary artery endothelial cells; siRNA knockdown of HIF-1α abolishes the proangiogenic effect of POSTN; blockade of TrkB (tyrosine kinase receptor B) attenuates POSTN-induced HIF-1α expression; HIF-1α inhibition reduces POSTN and TrkB expression. siRNA knockdown of POSTN and HIF-1α in human pulmonary artery endothelial cells, genetic epistasis (Sugen 5416/hypoxia and chronic hypoxia mouse models), TrkB blockade, gene expression analysis Circulation research Medium 32752980
2020 Periostin modulates myofibroblast differentiation and contraction via the integrinβ1/RhoA pathway; periostin is required for formation of focal and fibrillar adhesions in palatal fibroblasts; exogenous recombinant periostin rescues the deficient collagen gel contraction of Postn-/- fibroblasts; Rac inhibition rescues the deficient myofibroblastic phenotype of Postn-/- cells; fibronectin synthesis in response to low stiffness is periostin-dependent. Periostin-knockout mice, palatal wound model, collagen gel contraction assay, recombinant periostin rescue, silicon substrate stiffness experiments, pharmacological Rac inhibition, immunofluorescence for vinculin and integrinβ1 Matrix biology : journal of the International Society for Matrix Biology High 32777343
2020 Periostin mediates condylar resorption in TMJ-OA via NF-κB-ADAMTS5 signaling: periostin induces IκBα phosphorylation and degradation, p65 nuclear translocation, and subsequent ADAMTS5 expression in chondrocytes; NF-κB inhibition (BAY 11-7082) rescues periostin-induced ADAMTS5 upregulation. In vitro pressure chamber model, Western blot (IκBα phosphorylation), immunofluorescence (p65 nuclear translocation), NF-κB inhibitor (BAY 11-7082), gene expression analysis Inflammation Medium 31840212
2020 POSTN promotes vascular calcification in diabetes by blocking autophagic flux in vascular smooth muscle cells: POSTN upregulation impairs autophagosome-lysosome fusion in an intracellular ROS-dependent manner; inhibition of POSTN alleviates AGEs-BSA-induced autophagic flux blockade and attenuates VSMC calcification. POSTN siRNA knockdown, recombinant POSTN treatment, Western blot (Beclin1, LC3-II, P62), co-localization of LC3-II and LAMP1, ROS measurement, diabetic rat vascular calcification model Cellular signalling Medium 33744420
2020 Silencing of POSTN in pericytes in 3D co-culture experiments attenuates vessel number, vessel length, and endothelial junction formation; pericytes are identified as the main source of periostin in human gliomas (co-localization with PDGFRβ+ cells, not OLIG2+/SOX2+ glioma stem cells). POSTN siRNA silencing, 3D in vitro angiogenesis co-culture model, RT-PCR, immunohistochemistry, double labeling and in situ RNA hybridization Journal of neuropathology and experimental neurology Medium 32647861
2021 POSTN expression in glioblastoma stem cells (GSCs) promotes GSC self-renewal and tumor growth via activation of the αVβ3/PI3K/AKT/β-catenin/FOSL1 pathway; ChIP-seq and ChIP-PCR confirmed β-catenin binding to the FOSL1 promoter; POSTN also recruits microglia and upregulates CD70 expression through the αVβ3/PI3K/AKT/NFκB pathway, promoting Treg development and immunosuppression. POSTN knockdown, tumorsphere formation assay, ChIP-seq and ChIP-PCR, Transwell migration assay, CFSE staining, ELISA, apoptosis assay, patient-derived xenograft model, orthotopic glioma mouse model Journal of experimental & clinical cancer research : CR High 39227950
2023 Hyperglycemia stimulates periostin expression in cardiac fibroblasts via TGF-β/Smad-dependent signaling; periostin upregulates NAP1L2 expression, which recruits SIRT3 to deacetylate H3K27ac on promoters of BCAA catabolism enzymes (BCAT2 and PP2Cm), resulting in BCAA catabolism impairment; glucosyringic acid specifically targets and inhibits periostin to ameliorate diabetic cardiomyopathy. RNA sequencing, gain- and loss-of-function experiments (periostin-deficient mice, overexpression), TGF-β/Smad pathway analysis, ChIP for H3K27ac, SIRT3 deacetylation assay, pharmacological targeting (glucosyringic acid), primary cardiomyocyte co-culture Cellular & molecular biology letters High 37993768
2023 Periostin-expressing CAFs (periostin+ CAFs) are spatially enriched at periductal and perivascular/lymphatic vessel margins; genetic depletion of periostin+ CAFs impairs intratumoral collagen organization and inhibits lymphatic (but not lung) metastases; periostin ablation in CAFs reduces their ability to deposit aligned collagen matrices and inhibits cancer cell invasion through collagen and across lymphatic endothelial cell monolayers. In vivo genetic lineage tracing and ablation of periostin+ cells, collagen organization analysis, Transwell invasion assay across collagen and lymphatic endothelial cell monolayers, in vivo metastasis analysis Cancer research High 37205636
2025 Periostin marks pulmonary myofibroblasts; ablation of Postn+ myofibroblasts after lung injury ameliorates fibrosis; PIEZO1 is highly expressed in Postn+ myofibroblasts and mediates mechanoactivation; conditional deletion of Piezo1 in Postn+ myofibroblasts suppresses myofibroblast activation and proliferation, disrupts actin organization, and prevents Yap/Taz nuclear localization, shifting myofibroblasts to a stressed/apoptotic state; myofibroblast-specific Yap/Taz deletion recapitulates the protective phenotypes of myofibroblast-Piezo1-KO mice. Conditional cell-type-specific knockout (Postn-Cre-based Piezo1 and Yap/Taz deletion), cell ablation model, actin organization imaging, Yap/Taz nuclear localization assay, bleomycin-induced fibrosis model The Journal of clinical investigation High 40454481

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 The role of periostin in tissue remodeling across health and disease. Cellular and molecular life sciences : CMLS 337 24146092
2009 The multifaceted role of periostin in tumorigenesis. Cellular and molecular life sciences : CMLS 280 19308325
2011 Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cellular and molecular life sciences : CMLS 261 21833583
2009 Origin of cardiac fibroblasts and the role of periostin. Circulation research 240 19893021
2014 Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix biology : journal of the International Society for Matrix Biology 161 24813586
2012 The multiple facets of periostin in bone metabolism. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 160 22310955
2004 Expression and function of periostin-isoforms in bone. Journal of cellular biochemistry 157 15258926
2016 Roles of Periostin in Respiratory Disorders. American journal of respiratory and critical care medicine 146 26756066
2007 Periostin: novel diagnostic and therapeutic target for cancer. Histology and histopathology 141 17616943
2015 Periostin action in bone. Molecular and cellular endocrinology 136 26721738
2017 Periostin in inflammation and allergy. Cellular and molecular life sciences : CMLS 124 28887633
2017 The role of periostin in lung fibrosis and airway remodeling. Cellular and molecular life sciences : CMLS 119 28918442
2012 Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis. Allergology international : official journal of the Japanese Society of Allergology 115 22918213
2016 Periostin as a multifunctional modulator of the wound healing response. Cell and tissue research 108 27234502
2019 Periostin: An emerging biomarker for allergic diseases. Allergy 104 30964557
2020 Stromal POSTN induced by TGF-β1 facilitates the migration and invasion of ovarian cancer. Gynecologic oncology 102 33317907
2014 Periostin in allergic inflammation. Allergology international : official journal of the Japanese Society of Allergology 102 24662806
2017 Periostin in cardiovascular disease and development: a tale of two distinct roles. Basic research in cardiology 97 29101484
2024 POSTN+ cancer-associated fibroblasts determine the efficacy of immunotherapy in hepatocellular carcinoma. Journal for immunotherapy of cancer 94 39067872
2023 Single-cell and spatial transcriptomics reveal POSTN+ cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer. Clinical and translational medicine 93 38115703
2022 Periostin: biology and function in cancer. Cancer cell international 92 36224629
2021 Periostin in Allergy and Inflammation. Frontiers in immunology 87 34512647
2017 Periostin function in communication with extracellular matrices. Journal of cell communication and signaling 86 29086200
2015 Periostin: its role in asthma and its potential as a diagnostic or therapeutic target. Respiratory research 80 25981515
2007 BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis. Developmental biology 79 18261719
2019 Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI. Journal of the American Society of Nephrology : JASN 74 31690575
2014 Matricellular protein periostin contributes to hepatic inflammation and fibrosis. The American journal of pathology 72 25541330
2022 Periostin: an emerging activator of multiple signaling pathways. Journal of cell communication and signaling 71 35412260
2014 Periostin expression contributes to cortical bone loss during unloading. Bone 70 25445447
2016 Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models. Molecular cancer therapeutics 68 27307601
2016 Using Periostin as a Biomarker in the Treatment of Asthma. Allergy, asthma & immunology research 66 27582399
2014 PERIOSTIN: role in formation and maintenance of dental tissues. Journal of cellular physiology 66 23702840
2015 Expression and pathological effects of periostin in human osteoarthritis cartilage. BMC musculoskeletal disorders 65 26289167
2004 Identification and detection of the periostin gene in cardiac development. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 62 15532025
2014 Periostin in skin tissue and skin-related diseases. Allergology international : official journal of the Japanese Society of Allergology 60 24759560
2017 The multifaceted role of periostin in priming the tumor microenvironments for tumor progression. Cellular and molecular life sciences : CMLS 59 28884337
2009 Periostin-like-factor in osteogenesis. Journal of cellular physiology 59 19006175
2020 Periostin: A Potential Therapeutic Target For Pulmonary Hypertension? Circulation research 57 32752980
2017 Introductory review: periostin-gene and protein structure. Cellular and molecular life sciences : CMLS 57 28884327
2017 Periostin and its interacting proteins in the construction of extracellular architectures. Cellular and molecular life sciences : CMLS 56 28887577
1995 Expression and characterization of murine osteoblast-specific factor 2 (OSF-2) in a baculovirus expression system. Protein expression and purification 54 7663166
2017 Functions of Periostin in dental tissues and its role in periodontal tissues' regeneration. Cellular and molecular life sciences : CMLS 52 28889194
2015 The role of periostin in neoplastic processes. Folia histochemica et cytobiologica 52 26150285
2022 The Role of Periostin in Angiogenesis and Lymphangiogenesis in Tumors. Cancers 48 36077762
2015 Mechanical Force-induced TGFB1 Increases Expression of SOST/POSTN by hPDL Cells. Journal of dental research 48 25870205
2014 Expressions and roles of periostin in otolaryngological diseases. Allergology international : official journal of the Japanese Society of Allergology 48 24759558
2015 Periostin in Allergic Inflammation. Allergology international : official journal of the Japanese Society of Allergology 45 28942959
2021 Periostin, an Emerging Player in Itch Sensation. The Journal of investigative dermatology 44 34023128
2019 Periostin in Bone Regeneration. Advances in experimental medicine and biology 40 31037624
2014 Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications. Experimental and molecular pathology 39 25446840
2024 Single-Cell RNA Sequencing Reveals Dysregulated POSTN+WNT5A+ Fibroblast Subclusters in Prurigo Nodularis. The Journal of investigative dermatology 38 38246584
2018 Periostin Limits Tumor Response to VEGFA Inhibition. Cell reports 36 29514082
2017 Periostin in the pathogenesis of skin diseases. Cellular and molecular life sciences : CMLS 36 28916993
2007 Expression of periostin and its clinicopathological relevance in gastric cancer. World journal of gastroenterology 35 17876898
2016 p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression. Oncotarget 34 26930720
2019 Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 30991832
2015 Role of pancreatic stellate cells and periostin in pancreatic cancer progression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 32 25840689
2017 Experimental Inhibition of Periostin Attenuates Kidney Fibrosis. American journal of nephrology 31 29268247
2015 Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis. World journal of gastroenterology 31 25759527
2015 Elevated expression of periostin in diabetic cardiomyopathy and the effect of valsartan. BMC cardiovascular disorders 31 26281830
2020 Periostin interaction with discoidin domain receptor-1 (DDR1) promotes cartilage degeneration. PloS one 29 32330138
2020 Periostin and matrix stiffness combine to regulate myofibroblast differentiation and fibronectin synthesis during palatal healing. Matrix biology : journal of the International Society for Matrix Biology 29 32777343
2021 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases. Frontiers in medicine 27 34513869
2020 Role of serum periostin in the management of asthma and its comorbidities. Respiratory investigation 27 32205146
2017 Expression of periostin in breast cancer cells. International journal of oncology 27 28902360
2019 Periostin Functions as a Scaffold for Assembly of Extracellular Proteins. Advances in experimental medicine and biology 26 31037621
2025 PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. The Journal of clinical investigation 25 40454481
2024 Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis. The Journal of investigative dermatology 25 38218364
2022 The Multiple Roles of Periostin in Non-Neoplastic Disease. Cells 25 36611844
2020 Periostin Is Expressed by Pericytes and Is Crucial for Angiogenesis in Glioma. Journal of neuropathology and experimental neurology 25 32647861
2019 The Multiaspect Functions of Periostin in Tumor Progression. Advances in experimental medicine and biology 25 31037631
2017 Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis. Gene therapy 25 28820502
2012 P-N bond protein phosphatases. Biochimica et biophysica acta 25 22450136
2023 Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis. Cellular & molecular biology letters 24 37993768
2020 Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy. Scientific reports 24 32518264
2019 Periostin in Bone Biology. Advances in experimental medicine and biology 24 31037623
2019 Elevation of circular RNA circ-POSTN facilitates cell growth and invasion by sponging miR-1205 in glioma. Journal of cellular biochemistry 24 31081163
2017 Periostin in kidney diseases. Cellular and molecular life sciences : CMLS 24 28884334
2011 Expression patterns and roles of periostin during kidney and ureter development. The Journal of urology 24 21855915
2019 Periostin in the Kidney. Advances in experimental medicine and biology 23 31037629
2019 MicroRNA-98-HMGA2-POSTN signal pathway reverses epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 22 31207579
2019 Plasma Periostin and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 21 30635868
2019 Periostin and Integrin Signaling in Stem Cell Regulation. Advances in experimental medicine and biology 21 31037634
2017 Periostin-binding DNA aptamer treatment attenuates renal fibrosis under diabetic conditions. Scientific reports 21 28819200
2014 Periostin induces pancreatic regeneration. Endocrinology 21 25485969
2020 Periostin Mediates Condylar Resorption via the NF-κB-ADAMTS5 Pathway. Inflammation 20 31840212
2024 The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma. Journal of experimental & clinical cancer research : CR 19 39227950
2023 The role of periostin in cardiac fibrosis. Heart failure reviews 19 37870704
2021 POSTN promotes diabetic vascular calcification by interfering with autophagic flux. Cellular signalling 19 33744420
2019 Functions of Periostin in Dental Tissues and Its Role in Periodontal Tissue Regeneration. Advances in experimental medicine and biology 19 31037625
2022 Periostin: A Potential Biomarker and Therapeutic Target in Pulmonary Diseases. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 18 35379385
2022 Periostin as a biomarker in chronic rhinosinusitis: A contemporary systematic review. International forum of allergy & rhinology 18 35514144
2020 Role of COL3A1 and POSTN on Pathologic Stages of Esophageal Cancer. Technology in cancer research & treatment 18 33280513
2019 Involvement of Periostin in Skin Function and the Pathogenesis of Skin Diseases. Advances in experimental medicine and biology 18 31037628
2019 Roles of Periostin in Asthma. Advances in experimental medicine and biology 18 31037633
2023 Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness. Scientific reports 17 38049490
2019 Practical Application of Periostin as a Biomarker for Pathological Conditions. Advances in experimental medicine and biology 17 31037636
2023 Periostin+ Stromal Cells Guide Lymphovascular Invasion by Cancer Cells. Cancer research 16 37205636
2019 Periostin and Inflammatory Disease: Implications for Chronic Rhinosinusitis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 16 30935271
2015 Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity. Breast cancer research : BCR 15 25592291

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