Affinage

PDS5B

Sister chromatid cohesion protein PDS5 homolog B · UniProt Q9NTI5

Length
1447 aa
Mass
164.7 kDa
Annotated
2026-06-10
100 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PDS5B (APRIN/AS3) is a vertebrate HEAT-repeat cohesin-associated protein that functions both in sister chromatid cohesion and in homologous recombination repair (PMID:24141881, PMID:22293751). Within the cohesin ring it forms a curved structure bridging the Smc3–Scc1 and SA1–Scc1 interfaces, contacting all other cohesin subunits and encircling the Smc1/Smc3 nucleotide-binding domains (PMID:27549742). PDS5B enables cohesion establishment by facilitating Smc3 acetylation by Esco1/2 and subsequent Sororin binding, and is specifically required for centromeric cohesion and for Aurora B accumulation at the inner centromere, so its loss drives chromosome mis-segregation and aneuploidy (PMID:24141881). It protects centromeric cohesin in mitosis by binding the histone kinase Haspin through a conserved YGA/R motif, antagonizing Wapl-mediated cohesin release (PMID:28343965). Independently of cohesin, PDS5B promotes homologous recombination: it associates with BRCA2 and is required for nuclear localization of RAD51 and BRCA2 (PMID:22293751), binds RAD51, PALB2, and BRCA2 directly along with D-loop and ssDNA structures to stimulate RAD51-mediated strand invasion and counteract RPA inhibition of RAD51 loading (PMID:27924011), and acts in the Shu-complex pathway (SWS1, SWSAP1, SPIDR) to promote RAD51 foci formation and replication fork restart (PMID:31665741). Beyond these roles, PDS5B mediates androgen-induced proliferative arrest in prostate cells (PMID:10963680, PMID:12072405), coordinates stem/progenitor differentiation programs (PMID:20383194), and associates with the meiotic chromosome axis in spermatocytes (PMID:24710098). Knockout mice die perinatally with multiple congenital anomalies resembling Cornelia de Lange syndrome, yet without detectable cohesion defects, indicating essential developmental functions distinct from its cohesion role (PMID:17652350).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2000 Medium

    Established the first functional readout for PDS5B as AS3, identifying it as a mediator of androgen-induced proliferative shutoff before its cohesin role was known.

    Evidence tetracycline-regulated sense/antisense AS3 expression and proliferation assays in prostate cancer cells

    PMID:10963680

    Open questions at the time
    • No molecular mechanism beyond correlation with proliferation arrest
    • Link to chromatin/cohesin function not yet made
  2. 2002 Medium

    Confirmed in vivo that AS3/PDS5B expression marks non-proliferating prostate epithelium, anchoring its anti-proliferative role to physiological androgen state.

    Evidence immunohistochemistry of intact, castrated, and testosterone-replaced rat prostate with BrdU co-labelling

    PMID:12072405

    Open questions at the time
    • No downstream molecular effector identified
    • Mechanism linking androgen signaling to PDS5B expression unresolved
  3. 2007 Medium

    Defined PDS5B as a vertebrate Pds5 paralog with novel chromatin-regulatory domains, and showed via knockout that it is developmentally essential with functions seemingly beyond cohesion.

    Evidence comparative domain analysis, fractionation/immunofluorescence localization, and germline knockout mouse phenotyping

    PMID:17652350 PMID:17997301

    Open questions at the time
    • No cohesion defect detected, leaving developmental mechanism unexplained
    • Function of HMG-like/DNA-binding domains not tested
    • Nucleolar localization role uncharacterized
  4. 2010 Medium

    Extended PDS5B function to cell-fate programs by linking it to differentiation control.

    Evidence siRNA knockdown in embryonal carcinoma stem cells with pluripotency/differentiation marker profiling

    PMID:20383194

    Open questions at the time
    • No rescue experiment
    • Mechanism connecting PDS5B to Oct4/Nanog/SOX2 regulation unknown
  5. 2012 High

    Identified PDS5B/APRIN as a BRCA2-associated protein required for RAD51/BRCA2 nuclear localization and efficient HR, opening its DNA-repair role.

    Evidence proteomic Co-IP, siRNA knockdown, HR reporter assay, immunofluorescence after replication stress

    PMID:22293751

    Open questions at the time
    • Direct biochemical activity not yet defined
    • Distinction from cohesin role not established at this stage
  6. 2013 High

    Resolved the core mitotic mechanism: PDS5B enables Smc3 acetylation/Sororin loading and is specifically required for centromeric cohesion and Aurora B accumulation.

    Evidence siRNA knockdown of Pds5A/B with cohesion, acetylation, Aurora B localization, and aneuploidy readouts

    PMID:24141881

    Open questions at the time
    • Mechanism of Aurora B recruitment downstream of PDS5B not detailed
    • Did not reconcile with absence of cohesion defect in knockout cells
  7. 2016 High

    Provided the structural basis for PDS5B as an integral cohesin component and biochemically reconstituted its HR-stimulating activities.

    Evidence single-particle EM and crosslinking-MS of bonsai cohesin; purified-protein strand-invasion, ssDNA, and D-loop binding assays

    PMID:27549742 PMID:27924011

    Open questions at the time
    • High-resolution structure of full-length PDS5B in cohesin lacking
    • How DNA-binding and cohesin roles are coordinated unresolved
  8. 2017 High

    Defined the molecular interaction protecting centromeric cohesion: Haspin binds PDS5B via a YGA/R motif to antagonize Wapl.

    Evidence Co-IP, knockin/knockout, centromeric targeting and rescue assays with Wapl/Sgo1 epistasis

    PMID:28343965

    Open questions at the time
    • Structural detail of the YGA/R-PDS5B interface not resolved
    • Quantitative competition with Wapl binding not measured
  9. 2019 Medium

    Connected PDS5B to the Shu-complex/replication-fork-restart pathway and confirmed both its essentiality and tumor-suppressive roles.

    Evidence CRISPR KO and Co-IP with Shu members, RAD51 foci/SCE/drug-sensitivity assays; miR-223 luciferase targeting and Ptch2/Hedgehog rescue in pancreatic cancer; transgene-disruption mouse lethality

    PMID:26334628 PMID:30776580 PMID:31233836 PMID:31665741

    Open questions at the time
    • How PDS5B integrates Shu-complex and BRCA2/RAD51 functions unclear
    • Mechanism of Ptch2 regulation not defined
    • Relationship between tumor-suppressor and cohesin/HR roles unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PDS5B's cohesin-structural, HR-promoting, developmental, and differentiation functions are mechanistically partitioned and coordinated within a single protein remains unresolved.
  • The cohesion-independent developmental defects in knockout mice lack a molecular mechanism
  • No unified model explaining nucleolar localization and chromatin-regulatory domains
  • Mechanistic basis for the Cornelia de Lange-like phenotype not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0003677 DNA binding 2 GO:0005198 structural molecule activity 1
Localization
GO:0005634 nucleus 3 GO:0000228 nuclear chromosome 2 GO:0005730 nucleolus 1
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-73894 DNA Repair 3 R-HSA-1266738 Developmental Biology 2 R-HSA-69306 DNA Replication 1
Partners
BRCA2HASPINPALB2RAD51SPIDRSWS1SWSAP1WAPL
Complex memberships
Shu complexcohesin

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 Pds5B is essential for cohesion establishment by enabling Smc3 acetylation by cohesin acetyltransferases Esco1/2 and subsequent Sororin binding; Pds5B is specifically required for centromeric cohesion (while both Pds5A and Pds5B contribute to telomere and arm cohesion); depletion of Pds5B reduces Aurora B accumulation at the inner centromere, impairing error correction and promoting chromosome mis-segregation and aneuploidy. siRNA knockdown of Pds5A/B in vertebrate somatic cells, immunofluorescence, cohesion assays, flow cytometry for aneuploidy The EMBO journal High 24141881
2017 The mitotic histone kinase Haspin binds directly to Pds5B through a conserved YGA/R motif in its non-catalytic N-terminus (similar to Wapl's YSR-motif-dependent binding to Pds5B); this Haspin–Pds5B interaction protects centromeric cohesion in mitosis by antagonizing Wapl-mediated cohesin release, and disruption of the interaction causes weakened centromeric cohesion and premature chromatid separation. Co-IP, knockout/knockin experiments, centromeric targeting of N-terminal Haspin fragments, rescue assays, immunofluorescence Current biology : CB High 28343965
2016 Pds5B forms a curved HEAT-repeat structure that bridges the Smc3–Scc1 and SA1–Scc1 interfaces, contacting all other cohesin subunits and forming an integral part of the cohesin ring; structural modeling shows Pds5B encircles the nucleotide-binding domains of Smc1 and Smc3. Single-particle electron microscopy of engineered 'bonsai' cohesin, chemical crosslinking-mass spectrometry, in silico modelling Nature communications High 27549742
2012 APRIN (PDS5B) is a BRCA2-associated protein that, after DNA damage (hydroxyurea/aphidicolin), associates with BRCA2 and other cohesin components in early S-phase; APRIN expression is required for the nuclear localisation of RAD51 and BRCA2 and for efficient homologous recombination; BRCA2 missense variants of unknown significance compromise the BRCA2–APRIN interaction. Proteomic profiling/Co-IP to identify BRCA2 interaction, siRNA knockdown, HR reporter assay, immunofluorescence for RAD51/BRCA2 nuclear localisation The EMBO journal High 22293751
2016 APRIN (PDS5B) interacts directly with RAD51, PALB2, and BRCA2; APRIN binds DNA with affinity for D-loop structures and ssDNA; APRIN stimulates RAD51-mediated DNA strand invasion and strongly promotes annealing of complementary-strand DNA, counteracting the RPA inhibitory effect on RAD51 loading; APRIN depletion has no impact on class switch recombination, indicating a specific role in homologous recombination independent of cohesin. Purified protein pull-downs, in vitro DNA strand invasion assay, ssDNA binding assay, D-loop binding assay, class switch recombination assay, siRNA knockdown Nucleic acids research High 27924011
2019 PDS5B (APRIN) interacts with the human Shu complex members SWS1 and SWSAP1, and with SPIDR, functioning in the same genetic pathway upon DNA damage; PDS5B promotes RAD51 recruitment to DNA repair foci and is required for replication fork restart following stalling. CRISPR/Cas9 deletion of Shu complex members, Co-IP to identify PDS5B and SPIDR as Shu interactors, RAD51 foci assay, sister chromatid exchange assay, sensitivity to MMS and mitomycin C Nucleic acids research High 31665741
2007 PDS5B (APRIN) knockout mice die shortly after birth with multiple congenital anomalies (heart defects, cleft palate, rib fusion, short limbs, distal colon aganglionosis, abnormal sympathetic neuron migration/projections, germ cell depletion); unexpectedly, no cohesion defects were detected in Pds5B−/− cells; PDS5B shows high expression in post-mitotic neurons and nucleolar localization, suggesting functions beyond chromosomal cohesion. Knockout mouse generation and phenotypic analysis, BrdU incorporation, immunofluorescence for cohesion markers, subcellular localisation studies Development (Cambridge, England) High 17652350
2000 AS3 (PDS5B) protein expression mediates the androgen-induced proliferative shutoff in prostate cancer cells; tetracycline-regulated sense AS3 expression inhibits cell proliferation, whereas antisense AS3 blocks androgen-induced endogenous AS3 mRNA and abolishes the androgen-induced anti-proliferative effect. Stable tetracycline-regulated sense and antisense AS3 cell lines, cell proliferation assays, RT-PCR Proceedings of the National Academy of Sciences of the United States of America Medium 10963680
2002 AS3 (PDS5B) protein is expressed in nuclei of >90% of epithelial cells of the intact rat prostate and is absent in castrated rats or during the proliferative phase of androgen-induced regeneration; AS3 is not expressed in BrdU-incorporating (proliferating) cells, confirming its role as a mediator of proliferative arrest in vivo. Immunohistochemistry of rat prostate sections (intact, castrated, testosterone-replaced groups), BrdU co-labelling, tetracycline-regulated AS3 cell lines Endocrinology Medium 12072405
2007 APRIN (PDS5B) is a paralog of Pds5 that arose by gene duplication in early vertebrates; it localises to the euchromatin/heterochromatin interface in interphase nuclei; unlike canonical Pds5 proteins, APRIN contains HMG-like domains (hallmarks of chromatin regulators) and a defined DNA-binding domain and nuclear import signal, suggesting it acquired novel chromatin-regulatory functions in vertebrates. Comparative sequence/domain analysis, subcellular localisation by immunofluorescence, nuclear fractionation, domain mapping The Journal of steroid biochemistry and molecular biology Medium 17997301
2010 PDS5B expression is precisely coordinated with stem cell differentiation in embryonal carcinoma cells; PDS5B knockdown disrupts Oct4, Nanog, and SOX2 patterns, blocks differentiation, and results in cells that fail to progress beyond the proneural progenitor phase with retained c-Myc expression, resembling cancer-initiating cells. siRNA knockdown in embryonal carcinoma stem cell model, immunofluorescence for pluripotency and differentiation markers (Oct4, Nanog, SOX2, Mash-1, E-cadherin, N-cadherin, c-Myc) Oncogene Medium 20383194
2010 Mouse PDS5B is abundantly expressed in testis compared to other tissues; immunofluorescence shows high expression in spermatogonia with depletion from chromatin upon meiotic entry; during first meiotic prophase, PDS5B associates with axial chromosome cores and this association occurs independently of synaptonemal complex proteins SYCP1 and SYCP3, indicating PDS5B is an integral component of the cohesin-defined chromosome axis. Western blotting across tissues, immunofluorescence on spermatocyte spreads, analysis in SYCP1/SYCP3 knockout backgrounds Genes Medium 24710098
2019 PDS5B is a direct target of miR-223 in pancreatic cancer cells; PDS5B exhibits tumor-suppressive function, and ectopic overexpression of PDS5B reverses miR-223-mediated tumor progression (proliferation and invasion) in pancreatic cancer cells. Luciferase reporter assay (3′-UTR targeting), overexpression rescue experiments, MTT, FACS, Transwell invasion, animal studies Molecular therapy. Nucleic acids Medium 30776580
2019 PDS5B positively regulates the expression of Ptch2, thereby influencing Sonic hedgehog signaling; Ptch2 downregulation abolishes PDS5B-mediated anti-tumor activity (growth inhibition, apoptosis, reduced migration/invasion) in pancreatic cancer cells; PDS5B expression positively correlates with Ptch2 levels in patient samples. Overexpression and knockdown transfection, MTT, FACS, western blotting, wound healing, Transwell invasion, immunohistochemistry, rescue with Ptch2 knockdown Cancer letters Medium 31233836
2013 PDS5B harbors frameshift mutations in mononucleotide repeat coding sequences in 20.3% of gastric and colorectal cancers with high microsatellite instability (but not in MSS/MSI-low tumors); loss of PDS5B protein expression is detected by IHC in 19–47% of gastric and colorectal cancers and is more common in tumors with frameshift mutations or high MSI. SSCP analysis and DNA sequencing of 91 gastric and 100 colorectal cancers, immunohistochemistry Human pathology Low 23850494
2015 Homozygous disruption of the Pds5b gene (by integration of a Her2 transgene concatemer into Pds5b) causes embryonic lethality in mice, confirming the essential role of Pds5b in embryonic development. Whole genome sequencing to map transgene integration site, homozygous Her2+/+ (Pds5b−/−) mouse viability analysis PloS one Medium 26334628

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. Molecular cell 581 28985503
2018 A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1. Genome biology 232 30286788
2019 LncRNA MAGI2-AS3 Is Regulated by BRD4 and Promotes Gastric Cancer Progression via Maintaining ZEB1 Overexpression by Sponging miR-141/200a. Molecular therapy. Nucleic acids 114 31837602
2019 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications 94 31767858
2007 Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development (Cambridge, England) 90 17652350
2013 Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. The EMBO journal 80 24141881
2016 Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget 78 27566578
2000 Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Proceedings of the National Academy of Sciences of the United States of America 74 10963680
2020 Deregulated lncRNA MAGI2-AS3 in Alzheimer's disease attenuates amyloid-β induced neurotoxicity and neuroinflammation by sponging miR-374b-5p. Experimental gerontology 69 33279663
2018 Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway. Human cell 68 29679339
2019 LncRNA MAGI2-AS3 inhibits hepatocellular carcinoma cell proliferation and migration by targeting the miR-374b-5p/SMG1 signaling pathway. Journal of cellular physiology 66 30924168
2005 The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+. Free radical biology & medicine 63 16274885
2019 LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells. Oncogenesis 62 31615976
2017 The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis. Current biology : CB 62 28343965
2018 Long noncoding RNA MAGI2-AS3 regulates CCDC19 expression by sponging miR-15b-5p and suppresses bladder cancer progression. Biochemical and biophysical research communications 58 30442369
2012 APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. The EMBO journal 57 22293751
2012 Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood transfusion = Trasfusione del sangue 54 22890268
2020 lncRNA HOXB-AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K-AKT pathway. Journal of cellular physiology 52 32039488
2000 Feasibility and safety of AS-3 red blood cells for neonatal transfusions. The Journal of pediatrics 48 10657828
2019 Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a. Cancer biomarkers : section A of Disease markers 44 30883342
2020 MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2. Journal of cellular physiology 43 32730644
2019 lncRNA MAGI2-AS3 Prevents the Development of HCC via Recruiting KDM1A and Promoting H3K4me2 Demethylation of the RACGAP1 Promoter. Molecular therapy. Nucleic acids 43 31629962
2016 Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature communications 43 27549742
2016 Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic acids research 43 27924011
2019 Long noncoding MAGI2-AS3 promotes colorectal cancer progression through regulating miR-3163/TMEM106B axis. Journal of cellular physiology 42 31709544
2022 LncRNA HOXC-AS3 promotes non-small-cell lung cancer growth and metastasis through upregulation of YBX1. Cell death & disease 39 35387975
2020 LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis. Journal of cellular and molecular medicine 39 32918360
2013 Lower citrinin production by gene disruption of ctnB involved in citrinin biosynthesis in Monascus aurantiacus Li AS3.4384. Journal of agricultural and food chemistry 39 23841779
2020 LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis. Aging 36 33231563
2019 The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic acids research 36 31665741
2021 PDS5A and PDS5B in Cohesin Function and Human Disease. International journal of molecular sciences 35 34070827
2022 Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8. Redox biology 34 35797800
2020 LncRNA MAGI2-AS3 Overexpression Sensitizes Esophageal Cancer Cells to Irradiation Through Down-Regulation of HOXB7 via EZH2. Frontiers in cell and developmental biology 33 33330444
2019 LncRNA HOXA-AS3 Sponges miR-29c to Facilitate Cell Proliferation, Metastasis, and EMT Process and Activate the MEK/ERK Signaling Pathway in Hepatocellular Carcinoma. Human gene therapy. Clinical development 33 30963785
2019 Long Non-Coding RNA MAGI2-AS3 is a New Player with a Tumor Suppressive Role in High Grade Serous Ovarian Carcinoma. Cancers 33 31842477
2018 Increased levels of the long noncoding RNA, HOXA-AS3, promote proliferation of A549 cells. Cell death & disease 33 29899328
2018 HOXC10 Regulates Osteogenesis of Mesenchymal Stromal Cells Through Interaction with Its Natural Antisense Transcript lncHOXC-AS3. Stem cells (Dayton, Ohio) 33 30353595
2016 Deleting the citrinin biosynthesis-related gene, ctnE, to greatly reduce citrinin production in Monascus aurantiacus Li AS3.4384. International journal of food microbiology 33 27838517
2020 LncRNA HOXB-AS3 promotes growth, invasion and migration of epithelial ovarian cancer by altering glycolysis. Life sciences 32 33148416
2000 The survival, function, and hemolysis of human RBCs stored at 4 degrees C in additive solution (AS-1, AS-3, or AS-5) for 42 days and then biochemically modified, frozen, thawed, washed, and stored at 4 degrees C in sodium chloride and glucose solution for 24 hours. Transfusion 32 11099662
2023 MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis: New Clinical Insights. ACS chemical neuroscience 31 36878000
2021 Roles of lncRNA MAGI2-AS3 in human cancers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 31 34126355
2016 The immune responses and expression of metallothionein (MT) gene and heat shock protein 70 (HSP 70) in juvenile rockfish, Sebastes schlegelii, exposed to waterborne arsenic (As3+). Environmental toxicology and pharmacology 31 27689810
2021 A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc. Oncology letters 30 34457052
2012 Arsenite oxidation in Ancylobacter dichloromethanicus As3-1b strain: detection of genes involved in arsenite oxidation and CO2 fixation. Current microbiology 30 22638843
2022 Low Glucose-Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer. Cancer research 29 35031573
2021 LncRNA HOXA-AS3 promotes gastric cancer progression by regulating miR-29a-3p/LTβR and activating NF-κB signaling. Cancer cell international 29 33602223
2020 LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia. RNA biology 29 32174258
2019 LncRNA MAGI2-AS3 suppresses the proliferation and invasion of non-small cell lung carcinoma through miRNA-23a-3p/PTEN axis. European review for medical and pharmacological sciences 28 31539127
2013 Cysteine accessibility during As3+ metalation of the α- and β-domains of recombinant human MT1a. Biochemical and biophysical research communications 28 23523794
2020 Long noncoding RNA MAGI2-AS3/miR-218-5p/GDPD5/SEC61A1 axis drives cellular proliferation and migration and confers cisplatin resistance in nasopharyngeal carcinoma. International forum of allergy & rhinology 27 32450008
2019 miR-223 Regulates Cell Proliferation and Invasion via Targeting PDS5B in Pancreatic Cancer Cells. Molecular therapy. Nucleic acids 27 30776580
2019 HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC-AS3. Journal of cellular biochemistry 27 31062400
2020 MAGI2-AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR-525-5p/MXD1 axis. Cancer medicine 26 32681706
2013 Frameshift mutations of chromosome cohesion-related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability. Human pathology 26 23850494
2020 Long Noncoding MAGI2-AS3 Suppresses Several Cellular Processes of Lung Squamous Cell Carcinoma Cells by Regulating miR-374a/b-5p/CADM2 Axis. Cancer management and research 25 32021443
2002 Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate. Endocrinology 25 12072405
2021 HOXA-AS3 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells via the miR-455-5p/PD-L1 Axis. Journal of immunology research 24 34988230
2020 As3+ or/and Cu2+ exposure triggers oxidative stress imbalance, induces inflammatory response and apoptosis in chicken brain. Ecotoxicology and environmental safety 24 32678762
2020 Oxidative damage under As3+ and/or Cu2+ stress leads to apoptosis and autophagy and may be cross-talking with mitochondrial disorders in bursa of Fabricius. Journal of inorganic biochemistry 23 31945648
2019 Long Noncoding RNA HOXA-AS3 Integrates NF-κB Signaling To Regulate Endothelium Inflammation. Molecular and cellular biology 23 31285272
2019 Long noncoding RNA RBMS3-AS3 acts as a microRNA-4534 sponge to inhibit the progression of prostate cancer by upregulating VASH1. Gene therapy 23 31712637
2021 LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma. Cancer gene therapy 22 34002044
2020 LncRNA MAGI2-AS3 is down-regulated in intervertebral disc degeneration and participates in the regulation of FasL expression in nucleus pulposus cells. BMC musculoskeletal disorders 22 32143617
2019 LncRNA MAGI2-AS3 is involved in cervical squamous cell carcinoma development through CDK6 up-regulation. Infectious agents and cancer 22 31832086
2021 Novel insights for lncRNA MAGI2-AS3 in solid tumors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 21 33761624
2020 LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer. Cancer biotherapy & radiopharmaceuticals 21 31910343
2018 lncRNA HOXB-AS3 promotes hepatoma by inhibiting p53 expression. European review for medical and pharmacological sciences 21 30402841
2020 LncRNA MAGI2-AS3 is downregulated in non-small cell lung cancer and may be a sponge of miR-25. BMC pulmonary medicine 20 32138716
2019 Arsenic-resistance mechanisms in bacterium Leclercia adecarboxylata strain As3-1: Biochemical and genomic analyses. The Science of the total environment 20 31470481
2019 A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis. Cancer investigation 20 31797701
2010 Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma: an emerging cohesin role in tumor suppression. Oncogene 20 20383194
1997 Toxic effects of arsenic (As3+) and other metal ions on acute promyelocytic leukemia cells. International journal of hematology 19 9071824
2021 Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p. Bioengineered 18 34698001
2015 Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene. PloS one 18 26334628
2020 Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p. Drug design, development and therapy 17 32982172
2019 PDS5B regulates cell proliferation and motility via upregulation of Ptch2 in pancreatic cancer cells. Cancer letters 17 31233836
2010 The Mouse Cohesin-Associated Protein PDS5B Is Expressed in Testicular Cells and Is Associated with the Meiotic Chromosome Axes. Genes 17 24710098
2009 Enhanced glutathione biosynthetic capacity promotes resistance to As3+-induced apoptosis. Toxicology letters 17 20006689
2023 Alternative splicing of HOXB-AS3 underlie the promoting effect of nuclear m6A reader YTHDC1 on the self-renewal of leukemic stem cells in acute myeloid leukemia. International journal of biological macromolecules 16 36906205
2021 Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis. Cancer biomarkers : section A of Disease markers 16 33104021
2020 LncRNA MAGI2-AS3 Affects Cell Invasion and Migration of Cervical Squamous Cell Carcinoma (CSCC) via Sponging miRNA-233/EPB41L3 Axis. Cancer management and research 16 32581592
2019 Engineering genetically encoded FRET-based nanosensors for real time display of arsenic (As3+) dynamics in living cells. Scientific reports 16 31375744
2015 Dose-dependent effects of selenite (Se(4+)) on arsenite (As(3+))-induced apoptosis and differentiation in acute promyelocytic leukemia cells. Cell death & disease 16 25590806
2007 APRIN is a unique Pds5 paralog with features of a chromatin regulator in hormonal differentiation. The Journal of steroid biochemistry and molecular biology 16 17997301
2024 LncRNA MAGI2-AS3 promotes fracture healing through downregulation of miR-223-3p. Journal of orthopaedic surgery and research 15 38907263
2023 lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axis. Genomics 15 36889366
2023 SETD1A-mediated H3K4me3 methylation upregulates lncRNA HOXC-AS3 and the binding of HOXC-AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells. Thoracic cancer 15 37548102
2022 Identification and Verification of a Novel MAGI2-AS3/miRNA-374-5p/FOXO1 Network Associated with HBV-Related HCC. Cells 15 36359865
2021 LncRNA HOXA-AS3 Promotes the Progression of Pulmonary Arterial Hypertension through Mediation of miR-675-3p/PDE5A Axis. Biochemical genetics 15 33687636
2021 Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma. The Journal of international medical research 15 34187214
2023 Contrasting response strategies of sulfate-reducing bacteria in a microbial consortium to As3+ stress under anaerobic and aerobic environments. Journal of hazardous materials 14 38056257
2021 Reduction of Bladder Cancer Chemosensitivity Induced by the Effect of HOXA-AS3 as a ceRNA for miR-455-5p That Upregulates Notch1. Frontiers in oncology 14 33643896
2012 Increased neuron specific enolase expression by urothelial cells exposed to or malignantly transformed by exposure to Cd²⁺ or As³⁺. Toxicology letters 14 22613180
2001 Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma. International journal of oncology 14 11295048
1992 Improved post-transfusion quality of density separated AS-3 red cells after extended storage. British journal of haematology 14 1419784
2022 Transcriptional suppression of Dicer by HOXB-AS3/EZH2 complex dictates sorafenib resistance and cancer stemness. Cancer science 13 35253323
2022 LncRNA MAGI2-AS3 Inhibits Prostate Cancer Progression by Targeting the miR-142-3p. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 13 35944561
2020 LncRNA MAGI2-AS3 is downregulated in the distant recurrence of hepatocellular carcinoma after surgical resection and affects migration and invasion via ROCK2. Annals of hepatology 13 32546442
2008 Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma. Journal of genetics and genomics = Yi chuan xue bao 13 18499069

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