- Length
- 1258 aa
- Mass
- 144.4 kDa
- Annotated
- 2026-04-28
124 papers in source corpus
27 papers cited in narrative
27 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Insufficient on-target evidence to synthesize a narrative — discovery timeline does not match the canonical STAG1 protein.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 27 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 1997 | SA-1 (STAG1) was identified as a novel nuclear protein of ~120 kDa expressed in hematopoietic organs, cloned from mouse stromal cell and human thymus cDNA libraries. A closely related paralog SA-2 was also cloned, sharing 71% identity. Subcellular fractionation demonstrated nuclear localization of SA-1 protein. | Lambda gt11 cDNA library screening with monoclonal antibody B92, RACE-PCR, immunoprecipitation/Western blotting, subcellular fractionation | Gene | Medium | 9305759 |
| 2009 | Cohesin-SA1 and cohesin-SA2 have distinct, non-redundant roles in sister chromatid cohesion: SA1 is specifically required for telomere cohesion after DNA replication in S phase, while SA2 is required for centromere cohesion. Depletion of SA1 but not SA2 caused loss of sister telomere cohesion, inability to repair chromatid breaks, and sister telomere loss. The telomere cohesion function of SA1 was shown to be linked to the telomeric protein TIN2. | siRNA depletion of SA1 or SA2 in human cells, fluorescence in situ hybridization (FISH) for telomere/centromere cohesion, live-cell imaging, cell cycle analysis | The Journal of cell biology | High | 19822671 |
| 2012 | SA1 is largely responsible for cohesin accumulation at gene promoters and CTCF-bound sites genome-wide. SA1 ablation alters transcription of genes related to Cornelia de Lange syndrome, and cohesin-SA1 positively regulates expression of myc and protocadherin genes at their promoters — a function that cannot be compensated by cohesin-SA2. | ChIP-seq in wild-type and SA1-null mouse embryonic fibroblasts, RNA-seq, SA1-null mouse embryo generation | The EMBO journal | High | 22415368 |
| 2012 | Complete SA1 ablation in mice causes embryonic lethality; heterozygous SA1-deficient animals show shorter lifespan and earlier tumor onset. SA1-null MEFs display increased aneuploidy and chromosome segregation defects arising specifically from defective telomere replication, not from impaired centromeric cohesion (which depends on cohesin-SA2). SA1 is thus specifically required for telomere replication-associated cohesion. | SA1-null mouse model generation, MEF culture, cytogenetic analysis, BrdU incorporation, metaphase spreads, telomere FISH | The EMBO journal | High | 22415365 |
| 2013 | SA1 binds directly to telomeric DNA through a unique AT-hook motif in its N-terminal domain (absent in SA2). Overexpression of SA1 alone is sufficient to induce cohesion at telomeres independently of the cohesin ring, and this requires the AT-hook-containing N-terminal domain. SA1 is highly enriched at telomeres by ChIP, decreases at mitosis when cohesion is resolved, and increases when cohesion persists. | ChIP in human cells, overexpression of SA1 truncation mutants, AT-hook mutation analysis, telomere cohesion assays by FISH | Journal of cell science | High | 23729739 |
| 2013 | SA1 and SA2 interact with RAD21 (Rad21/Scc1) through two distinct SA-binding motifs on RAD21: an N-terminal motif (aa 60-81) and a middle-part α-helical motif (aa 383-392). Mutation of three conserved residues (L385, F389, T390) in the α-helical motif significantly disrupts Rad21-SA1/2 interaction without affecting Smc1-Smc3-Rad21 interaction. Mutant Rad21 fails to rescue precocious chromosome separation caused by endogenous Rad21 depletion. | In vitro binding assays, co-immunoprecipitation (ex vivo), deletion mapping, site-directed mutagenesis, chromosome segregation rescue assay | PloS one | High | 23874961 |
| 2013 | Cohesin-SA2 (not SA1) is the main complex co-recruited with the cohesin-loading factor NIPBL to DNA damage sites in an S/G2-phase-specific manner. Replacing the diverged C-terminal region of SA1 with the corresponding region of SA2 confers DNA damage site accumulation activity on SA1. SA2 depletion (not SA1) decreased sister chromatid homologous recombination repair and affected DNA repair pathway choice. Both cohesin complexes function in the intra-S checkpoint. | Laser microirradiation with live-cell imaging, siRNA depletion, domain-swap chimera construction, sister chromatid exchange assay, cell cycle checkpoint analysis | Molecular and cellular biology | High | 24324008 |
| 2016 | SA1 displays two-state DNA binding behavior: non-specific 1D free diffusion for DNA searching, and subdiffusive sliding at telomeric regions for recognition. The AT-hook motif in SA1 modulates both non-specific DNA binding and subdiffusive dynamics over telomeric sequences. TRF1 tethers SA1 within telomeric regions, and together SA1 and TRF1 form longer DNA-DNA pairing tracts than TRF1 alone. | Single-molecule fluorescence imaging, 1D diffusion tracking on DNA tightropes, AT-hook mutant SA1, atomic force microscopy | Nucleic acids research | High | 27298259 |
| 2017 | STAG1 and STAG2 display a strong synthetic lethal interaction: STAG1 loss abrogates sister chromatid cohesion specifically in STAG2-mutated cells (not wild-type), leading to mitotic catastrophe, defective cell division, and apoptosis. Restoration of STAG2 expression alleviates dependence on STAG1. This synthetic lethality was demonstrated across bladder cancer and Ewing sarcoma cell lines. | CRISPR-Cas9 knockout, siRNA depletion, metaphase spread analysis, cell viability/proliferation assays, STAG2 re-expression rescue | eLife | High | 28691904 |
| 2018 | Cohesin-SA1 and cohesin-SA2 have distinct genomic distributions and non-redundant contributions to 3D genome organization: cohesin-SA1 preferentially stabilizes topologically associating domain (TAD) boundaries together with CTCF, while cohesin-SA2 promotes cell-type-specific enhancer-promoter contacts independently of CTCF. Loss of SA2 rewires local chromatin contacts in a way that cannot be compensated by SA1. | ChIP-seq for SA1 and SA2, Hi-C, RNA-seq in SA1- or SA2-depleted human cells, insulation score analysis | Nature structural & molecular biology | High | 29867216 |
| 2019 | Stag1 and Stag2 bind a shared set of genomic loci in hematopoietic stem and progenitor cells, but a component of Stag2 binding sites is unoccupied by Stag1. Stag2 loss decreased chromatin accessibility and transcription of lineage-specification genes (Ebf1, Pax5), increasing self-renewal and reducing B cell commitment. Concurrent loss of both Stag1 and Stag2 abrogated hematopoiesis entirely, demonstrating partial redundancy. | Conditional Stag2 deletion in mouse HSPCs, ChIP-seq for Stag1 and Stag2, ATAC-seq, RNA-seq, flow cytometry, hematopoietic reconstitution assay | Cell stem cell | High | 31495782 |
| 2019 | In mouse embryonic stem cells, cohesin-SA1 disrupts Polycomb domain interaction networks and preserves TAD borders, whereas cohesin-SA2 facilitates Polycomb domain compaction through PRC1 recruitment and promotes long-range interactions between Polycomb-bound promoters. These two modes of action reflect distinct roles: SA1 in loop extrusion with CTCF for TAD organization, SA2 in local transcriptional hub organization. | ChIP-seq, Hi-C, ChIA-PET, siRNA depletion of SA1 or SA2 in mESCs, PRC1 co-immunoprecipitation | Cell reports | High | 31216471 |
| 2020 | ESCO1 acetyltransferase and CTCF protect a subset of cohesin-STAG1 complexes from removal by WAPL, enabling formation of long chromatin loops. During G1 phase, acetylated cohesin-STAG1 binds chromatin for hours while cohesin-STAG2 binds for minutes. ESCO1 and CTCF together contribute to boundary formation in chromatin looping, consistent with a nested loop extrusion model where stable cohesin-STAG1 loops demarcate boundaries for more transient cohesin-STAG2 extrusion. | Auxin-inducible degron (AID) system for acute protein depletion, Hi-C, ChIP-seq, FRAP, co-immunoprecipitation | eLife | High | 32065581 |
| 2020 | Cohesin SA1 and SA2 are direct RNA-binding proteins. Both bind ssRNA, dsRNA, RNA:DNA hybrids, and R-loops in vitro, and localize to RNA-containing regions on dsDNA in single-molecule experiments. SA1 and SA2 binding sites overlap significantly with R-loop (DRIP-seq) sites in cells, with most R-loop-localized SA1/SA2 also binding other cohesin subunits. | Electrophoretic mobility shift assay (EMSA), atomic force microscopy (AFM), DNA tightrope single-molecule assay, ChIP-seq/DRIP-seq overlap analysis | Nucleic acids research | High | 32352519 |
| 2020 | STAG1 was identified as the most prominent and selective genetic dependency of STAG2-deficient cells in genome-wide CRISPR screens. X-ray crystallography identified the STAG1 regions that interact with RAD21. STAG1 mutations that abrogate interaction with RAD21 selectively compromise viability of STAG2-deficient cells. Chemical-genetic degradation of STAG1 using an inducible degron causes loss of sister chromatid cohesion and rapid cell death specifically in STAG2-deficient cells. | Genome-wide CRISPR screen, X-ray crystallography of STAG1-RAD21 interface, auxin-inducible degron system, metaphase spread, cell viability assay | Life science alliance | High | 32467316 |
| 2012 | Nuclear import of human SA1/STAG1 depends on a functional N-terminal NLS. In contrast to SA2 (which has multiple functional NLS and NES signals), SA1 has only one functional NLS, located at its N-terminus, with no functional nuclear export signals identified, suggesting SA1 is constitutively nuclear. | In silico NLS/NES prediction, expression of fluorescently tagged SA1/SA2 in Saccharomyces cerevisiae, validation in HeLa cells by confocal microscopy | PloS one | Medium | 22715410 |
| 2023 | TRF1, TIN2, and SA1 act synergistically to compact telomeric DNA. SA1 alone can compact telomeric DNA, and compaction by the full ternary TRF1-TIN2-SA1 system is additive (TRF1-TIN2 component plus SA1 component). Atomic force microscopy confirmed that all three proteins together drive strong intermolecular aggregation as required for chromosome cohesion. | Nanochannel DNA stretching to quantify compaction, atomic force microscopy of intermolecular aggregation, systematic comparison of protein subsets | Biophysical journal | Medium | 37081787 |
| 2023 | STAG1 is the dominant paralog in mouse embryonic stem cells and is required for pluripotency. The N-terminus of STAG1 specifically represses the two-cell (2C) embryonic state by maintaining rRNA expression and nucleolar integrity. Skewing the balance of naturally occurring STAG1 isoforms impacts cell identity. This role in nucleolar structure is distinct from STAG1's role in chromatin loop organization. | mESC STAG1 depletion, isoform-specific overexpression, RNA-seq for 2C gene markers, rRNA expression analysis, nucleolar morphology by immunofluorescence | Stem cell reports | Medium | 37802073 |
| 2024 | KPT-6566 was identified as a dual inhibitor of STAG1 and STAG2 that disrupts their interactions with SCC1 and double-stranded DNA. KPT-6566 causes premature chromosome separation, chromosome damage, impaired DNA damage repair, accumulation of double-strand breaks, and cell apoptosis in HeLa cells. It also sensitizes cells to PARP inhibitor Olaparib and NHEJ inhibitor UMI-77. | Fluorescence polarization high-throughput screening, biochemical/biophysical binding assays, metaphase chromosome spread assay, γH2AX immunofluorescence, cell viability assay | DNA repair | Medium | 39541712 |
| 2025 | STAG1 binds tightly to the trimeric SMC1/SMC3/SCC1 complex; this tetramer then weakly but cooperatively binds DNA. NIPBL binds DNA tightly and acts as a DNA anchor during the mechanochemical loop extrusion cycle. An ATP-modulated DNA binding site created by the STAG1-SMC1/SMC3/SCC1 interaction is important for repeated DNA grabbing and release critical to loop extrusion. | Mass photometry to quantify biomolecular interactions, systematic measurement of cohesin subunit assembly and DNA binding affinities, cohesin mutant analysis | Proceedings of the National Academy of Sciences of the United States of America | High | 40763028 |
| 2020 | Cohesin-STAG1 specifically contributes to stabilization of TAD boundaries together with CTCF, while cohesin-STAG2 promotes cell-type-specific contacts between enhancers and promoters independently of CTCF. These findings establish distinct 3D genome organization roles for the two cohesin variants. | ChIP-seq, Hi-C in multiple human cell types with SA1/SA2 depletion, insulation score analysis | Current opinion in genetics & development | Medium | 32294612 |
| 2025 | Cohesin-STAG1 extrudes DNA loops more efficiently than cohesin-STAG2 in single-molecule assays, despite comparable ATPase activity and topological DNA entrapment. The AT-hook motif unique to the STAG1 N-terminus promotes loop extrusion without altering ATPase activity or DNA binding. In human somatic cells, the AT-hook is required for stable cohesin-chromatin association during G1 phase (but dispensable for sister chromatid cohesion), and its mutation markedly impairs TAD and chromatin loop formation. | Single-molecule DNA loop extrusion assays, ATPase activity assay, Hi-C in cells expressing AT-hook mutant STAG1, ChIP-seq for cohesin residence | bioRxivpreprint | High | bio_10.1101_2025.11.17.688764 |
| 2025 | Stag1 depletion has negligible impact on post-mitotic genome restructuring or transcription reactivation during mitosis-to-G1 transition, whereas Stag2 orchestrates early-G1 chromatin remodeling. Simultaneous depletion of both Stag proteins results in synergistic loss of virtually all structural loops and more severe transcriptional disruption than individual deletions, demonstrating that Stag1 provides compensatory support during genome refolding. | Auxin-inducible degron for acute Stag1/Stag2 depletion during mitosis-to-G1 transition, Hi-C time course, RNA-seq, ChIP-seq | bioRxivpreprint | Medium | bio_10.1101_2025.10.24.684407 |
| 2025 | Molecular dynamics simulations predict that STAG1, together with SMC1, SMC3, and NIPBL, forms a DNA clamping patch group that facilitates DNA bending and capture within the cohesin ring, identifying specific high-affinity DNA binding patches on STAG1 implicated in loop extrusion. | Molecular dynamics simulations at amino-acid residue resolution, dissociation rate constant quantification as proxy for DNA affinity | bioRxivpreprint | Low | bio_10.1101_2024.09.17.613402 |
| 2025 | The CTCF N-terminal region contains two motifs (YDF and KTYQR) that hinder cohesin-mediated loop extrusion. The KTYQR motif fully impedes loop extrusion activity, while YDF converts cohesin into a unidirectional extruder by strengthening the affinity of STAG1 to DNA, revealing that CTCF stalls loop extrusion partly through modulating STAG1's DNA affinity. | Single-molecule DNA loop extrusion assay with CTCF N-terminal region fragments, force measurements, directionality analysis | bioRxivpreprint | Medium | bio_10.1101_2025.01.26.634934 |
| 2025 | Loss of SA1 (the Drosophila STAG1/2 homolog) during brain development leads to defects in neural stem cell differentiation and promotion of tumorigenesis. PARP inhibition combined with SA1/STAG2 depletion results in apoptosis in vitro and in vivo, and reduction of PARP activity ameliorates tumor-associated phenotypes of SA1-deficient Drosophila tissue, suggesting synthetic lethality between cohesin and PARP activity. | Drosophila RNAi knockdown of SA1 in brain tissue, human cell STAG2 depletion, PARP inhibitor treatment, tumor phenotype scoring, apoptosis assays | Disease models & mechanisms | Medium | 41502392 |
| 2025 | A frameshift STAG1 variant (c.500dup) causes dramatic reduction in STAG1 mRNA and protein through nonsense-mediated mRNA decay (NMD), establishing haploinsufficiency as the underlying pathogenic mechanism for STAG1-associated intellectual developmental disorder (MRD47). | Trio whole-exome sequencing, mutant STAG1 expression vector transfection into HEK293T cells, qRT-PCR for mRNA levels, Western blot for protein levels, NMD pathway analysis | Frontiers in pediatrics | Medium | 41210242 |
Source papers
Stage 0 corpus · 124 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2006 | A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | Cell | 610 | 16713569 |
| 2021 | Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. | Nature | 532 | 33845483 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2010 | Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. | Cell | 318 | 21145461 |
| 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. | PloS one | 312 | 23251661 |
| 2009 | A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. | The Journal of biological chemistry | 211 | 19460752 |
| 2001 | The DNA sequence and comparative analysis of human chromosome 20. | Nature | 168 | 11780052 |
| 2012 | Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. | The EMBO journal | 150 | 22415365 |
| 2022 | A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. | Nature biotechnology | 140 | 36217030 |
| 2009 | Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. | The Journal of cell biology | 140 | 19822671 |
| 2020 | N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors. | Biological psychiatry | 138 | 32387133 |
| 2017 | RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. | BMC biology | 135 | 29117863 |
| 2010 | TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. | Molecular cell | 135 | 20129061 |
| 2018 | Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. | Nature structural & molecular biology | 131 | 29867216 |
| 2020 | ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL. | eLife | 130 | 32065581 |
| 2019 | Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. | Cell stem cell | 129 | 31495782 |
| 2000 | A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. | Genomics | 122 | 10873380 |
| 2012 | A unique role of cohesin-SA1 in gene regulation and development. | The EMBO journal | 113 | 22415368 |
| 2003 | PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. | Cancer research | 102 | 12907594 |
| 2020 | Thermotolerance effect of plant growth-promoting Bacillus cereus SA1 on soybean during heat stress. | BMC microbiology | 101 | 32571217 |
| 2018 | Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. | Molecular & cellular proteomics : MCP | 101 | 30021884 |
| 2017 | Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts. | eLife | 93 | 28691904 |
| 2000 | Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. | The Biochemical journal | 92 | 11042109 |
| 2003 | PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. | Cancer research | 83 | 12670906 |
| 2019 | Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells. | Cell reports | 76 | 31216471 |
| 2013 | Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. | Molecular and cellular biology | 75 | 24324008 |
| 1988 | Purification, molecular cloning, and sequencing of salivary cystatin SA-1. | The Journal of biological chemistry | 75 | 2837486 |
| 2001 | Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. | Molecular carcinogenesis | 71 | 11568975 |
| 2008 | A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. | The Journal of biological chemistry | 69 | 18703514 |
| 2010 | Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer. | Cancer research | 65 | 20610632 |
| 2003 | EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer. | Molecular carcinogenesis | 63 | 14639658 |
| 1999 | Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin. | British journal of cancer | 61 | 10188880 |
| 2017 | Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1. | Oncotarget | 59 | 28430577 |
| 2008 | Pediocin SA-1, an antimicrobial peptide from Pediococcus acidilactici NRRL B5627: production conditions, purification and characterization. | Bioresource technology | 58 | 18093831 |
| 2010 | A randomized study of pegylated liposomal doxorubicin versus continuous-infusion doxorubicin in elderly patients with acute lymphoblastic leukemia: the GRAALL-SA1 study. | Haematologica | 57 | 20971822 |
| 2014 | TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells. | Cancer science | 55 | 24438557 |
| 2013 | TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways. | Carcinogenesis | 54 | 23615405 |
| 2011 | PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21 Cip1 signaling pathway. | The Journal of pathology | 54 | 21341270 |
| 2020 | Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture. | Current opinion in genetics & development | 52 | 32294612 |
| 2019 | PMEPA1 induces EMT via a non-canonical TGF-β signalling in colorectal cancer. | Journal of cellular and molecular medicine | 51 | 30887697 |
| 2020 | Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA. | Nucleic acids research | 48 | 32352519 |
| 2016 | Preliminary treatment of bovine mastitis caused by Staphylococcus aureus, with trx-SA1, recombinant endolysin of S. aureus bacteriophage IME-SA1. | Veterinary microbiology | 47 | 27374909 |
| 2014 | C18 ORF1, a novel negative regulator of transforming growth factor-β signaling. | The Journal of biological chemistry | 47 | 24627487 |
| 2017 | STAG1 mutations cause a novel cohesinopathy characterised by unspecific syndromic intellectual disability. | Journal of medical genetics | 45 | 28119487 |
| 2023 | The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system. | Journal of cell science | 42 | 36825945 |
| 2013 | Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. | PloS one | 40 | 23874961 |
| 2004 | Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. | Oncogene | 40 | 15361841 |
| 2020 | Extending thermotolerance to tomato seedlings by inoculation with SA1 isolate of Bacillus cereus and comparison with exogenous humic acid application. | PloS one | 39 | 32353077 |
| 1997 | SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. | Gene | 38 | 9305759 |
| 2013 | Enhanced CO2 sequestration by a novel microalga: Scenedesmus obliquus SA1 isolated from bio-diversity hotspot region of Assam, India. | Bioresource technology | 37 | 23811524 |
| 2020 | ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. | Antiviral research | 36 | 32858116 |
| 2024 | METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway. | International journal of biological sciences | 34 | 38385084 |
| 2013 | SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres. | Journal of cell science | 34 | 23729739 |
| 1991 | Induction of systemic lupus erythematosus in naive mice with T-cell lines specific for human anti-DNA antibody SA-1 (16/6 Id+) and for mouse tuberculosis antibody TB/68 (16/6 Id+). | Clinical immunology and immunopathology | 34 | 1830833 |
| 2015 | Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN. | Oncotarget | 31 | 25883222 |
| 2014 | TMEPAI inhibits TGF-β signaling by promoting lysosome degradation of TGF-β receptor and contributes to lung cancer development. | Cellular signalling | 31 | 24933703 |
| 2014 | Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1. | Cell calcium | 31 | 25266962 |
| 2020 | STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. | Life science alliance | 29 | 32467316 |
| 2006 | The structures of glycolipids isolated from the highly thermophilic bacterium Thermus thermophilus Samu-SA1. | Glycobiology | 29 | 16636007 |
| 2018 | The genome of 'Candidatus Phytoplasma solani' strain SA-1 is highly dynamic and prone to adopting foreign sequences. | Systematic and applied microbiology | 28 | 30455068 |
| 2014 | Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer. | Epigenetics | 28 | 24694733 |
| 2014 | CO2 biofixation and carbonic anhydrase activity in Scenedesmus obliquus SA1 cultivated in large scale open system. | Bioresource technology | 28 | 24865325 |
| 2004 | Setting optimal parameters for in vitro electrotransfection of B16F1, SA1, LPB, SCK, L929 and CHO cells using predefined exponentially decaying electric pulses. | Bioelectrochemistry (Amsterdam, Netherlands) | 27 | 14990328 |
| 2004 | NT3 expressed in skin causes enhancement of SA1 sensory neurons that leads to postnatal enhancement of Merkel cells. | The Journal of comparative neurology | 26 | 14991566 |
| 2016 | Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. | Nucleic acids research | 25 | 27298259 |
| 2012 | Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. | Journal of autoimmunity | 20 | 23122533 |
| 2018 | SA1/SA2 cohesion proteins and SIRT1-NAD+ deacetylase modulate telomere homeostasis in cumulus cells and are eligible biomarkers of ovarian aging. | Human reproduction (Oxford, England) | 19 | 29481647 |
| 1978 | A continuous culture study of the regulation of extracellular protease production in Vibrio SA1. | Antonie van Leeuwenhoek | 19 | 582093 |
| 2016 | Complete genome sequence of Novosphingobium resinovorum SA1, a versatile xenobiotic-degrading bacterium capable of utilizing sulfanilic acid. | Journal of biotechnology | 16 | 27851894 |
| 2024 | Jianpi qingre tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway. | Journal of ethnopharmacology | 15 | 39423944 |
| 2013 | Comparative phenotypic analysis and genome sequence of Clostridium beijerinckii SA-1, an offspring of NCIMB 8052. | Microbiology (Reading, England) | 15 | 24068240 |
| 2022 | Characterization and Genomic Analysis of a Novel Jumbo Bacteriophage vB_StaM_SA1 Infecting Staphylococcus aureus With Two Lysins. | Frontiers in microbiology | 14 | 35572667 |
| 2021 | Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase. | Plant physiology | 14 | 33793924 |
| 2021 | ML-SA1 and SN-2 inhibit endocytosed viruses through regulating TRPML channel expression and activity. | Antiviral research | 14 | 34687820 |
| 2021 | Novel STAG1 Frameshift Mutation in a Patient Affected by a Syndromic Form of Neurodevelopmental Disorder. | Genes | 13 | 34440290 |
| 2020 | Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. | Frontiers in cell and developmental biology | 13 | 33365313 |
| 2018 | Serpin A1 and the modulation of type I collagen turnover: Effect of the C-terminal peptide 409-418 (SA1-III) in human dermal fibroblasts. | Cell biology international | 12 | 29908000 |
| 2007 | High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. | Cellular & molecular biology letters | 12 | 17318295 |
| 2024 | Characterization of bacteriophage vB_AbaS_SA1 and its synergistic effects with antibiotics against clinical multidrug-resistant Acinetobacter baumannii isolates. | Pathogens and disease | 11 | 39435653 |
| 2017 | Starvation- and xenobiotic-related transcriptomic responses of the sulfanilic acid-degrading bacterium, Novosphingobium resinovorum SA1. | Applied microbiology and biotechnology | 11 | 29051988 |
| 2016 | Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications. | Cancer prevention research (Philadelphia, Pa.) | 11 | 27549371 |
| 1991 | Presence of a 16/6 related human anti-DNA common idiotype (SA1) in the anticardiolipin antibodies of patients with primary antiphospholipid syndrome. | The Journal of rheumatology | 11 | 1765979 |
| 2016 | Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas. | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology | 9 | 27341316 |
| 1998 | Association of 16/6 and SA1 anti-DNA idiotypes with anticardiolipin antibodies and clinical manifestations in a large cohort of SLE patients. European Concerted Action on the Immunogenetics of SLE. | Clinical and experimental rheumatology | 8 | 9844765 |
| 2012 | Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. | PloS one | 7 | 22715410 |
| 2024 | A Novel De Novo STAG1 Variant in Monozygotic Twins with Neurodevelopmental Disorder: New Insights in Clinical Heterogeneity. | Genes | 6 | 39336775 |
| 1993 | SA-1 antigen expression in small intensely fluorescent cells is associated with proliferation. | Developmental biology | 6 | 8099047 |
| 2023 | The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrity. | Stem cell reports | 5 | 37802073 |
| 2007 | Overlaps between the various biodegradation pathways in Sphingomonas subarctica SA1. | Acta biologica Hungarica | 5 | 18297793 |
| 2004 | Biochemical and genetic characterization of a D(-)-3-hydroxybutyrate dehydrogenase from Acidovorax sp. strain SA1. | Journal of bioscience and bioengineering | 5 | 16233594 |
| 2003 | Altered kinetic properties of tyrosine-183 to cysteine mutation in glutamine synthetase of anabaena variabilis strain SA1 is responsible for excretion of ammonium ion produced by nitrogenase. | Current microbiology | 5 | 12732949 |
| 2002 | Cloning and sequencing of an intracellular D(-)-3-hydroxybutyrate oligomer hydrolase from Acidovorax sp. strain SA1 and purification of the enzyme. | Current microbiology | 5 | 12070691 |
| 2024 | (S)-ML-SA1 Activates Autophagy via TRPML1-TFEB Pathway. | Chembiochem : a European journal of chemical biology | 4 | 38923811 |
| 2024 | A novel STAG1 variant associated with congenital clubfoot and microphthalmia: A case report. | SAGE open medical case reports | 4 | 39224759 |
| 2022 | Interactions between Jumbo Phage SA1 and Staphylococcus: A Global Transcriptomic Analysis. | Microorganisms | 4 | 36014008 |
| 2018 | High-Quality Draft Single-Cell Genome Sequence Belonging to the Archaeal Candidate Division SA1, Isolated from Nereus Deep in the Red Sea. | Genome announcements | 4 | 29748404 |
| 2018 | Draft genome sequence of Colletotrichum sansevieriae Sa-1-2, the anthracnose pathogen of Sansevieria trifasciata. | Data in brief | 4 | 29900221 |
| 2017 | Profiling Diuraphis noxia (Hemiptera: Aphididae) Transcript Expression of the Biotypes SA1 and SAM Feeding on Various Triticum aestivum Varieties. | Journal of economic entomology | 4 | 28334389 |
| 2007 | [Isolation and characterization of an atrazine-degrading bacterium strain SA1]. | Wei sheng wu xue bao = Acta microbiologica Sinica | 4 | 17672324 |
| 2006 | Prostate--specific G protein couple receptor genes and STAG1/PMEPA1 in peripheral blood from patients with prostatic cancer. | International journal of immunopathology and pharmacology | 4 | 17166409 |
| 1995 | Effect of surface antigen-1 (SA-1) immune lymphocyte subsets and naive cell subsets in protecting scid mice from initial and persistent infection with Cryptosporidium parvum. | Veterinary immunology and immunopathology | 4 | 8533299 |
| 1994 | Effects of vinblastine on cell membrane fluidity and the growth of SA-1 tumor in mice. | Cancer letters | 4 | 8187053 |
| 1978 | Purification and some properties of two extracellular proteolytic enzymes produced by Vibrio SA1. | Antonie van Leeuwenhoek | 4 | 36029 |
| 2020 | Chromosomal localization of PemIK toxin-antitoxin system results in the loss of toxicity - Characterization of pemIKSa1-Sp from Staphylococcus pseudintermedius. | Microbiological research | 3 | 32622987 |
| 2013 | Complete Genome Sequence of Simiduia agarivorans SA1(T), a Marine Bacterium Able To Degrade a Variety of Polysaccharides. | Genome announcements | 3 | 23405302 |
| 2025 | NIPBL and STAG1 enable loop extrusion by providing differential DNA-cohesin affinity. | Proceedings of the National Academy of Sciences of the United States of America | 2 | 40763028 |
| 2024 | Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro. | DNA repair | 2 | 39541712 |
| 2023 | Assembly path dependence of telomeric DNA compaction by TRF1, TIN2, and SA1. | Biophysical journal | 2 | 37081787 |
| 2025 | Neurological Disease Syndrome Caused by a STAG1 Gene Variant: A Case Report and Literature Review. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience | 1 | 40625213 |
| 2025 | Therapeutic potential of ECP-SA1: A novel lytic phage against multidrug-resistant Escherichia coli. | Microbial pathogenesis | 1 | 40769226 |
| 2023 | Periosteal Fasciitis With Unusual Radiologic Features Harboring a Novel STAG1::USP6 Fusion Gene. | International journal of surgical pathology | 1 | 36694417 |
| 2020 | Crystal structure of the YoeBSa1-YefMSa1 complex from Staphylococcus aureus. | Biochemical and biophysical research communications | 1 | 32446378 |
| 1985 | Expression of an antigen defined by a monoclonal antibody (SA-1) on normal and malignant cells. | Scandinavian journal of haematology | 1 | 4081640 |
| 2026 | Tumor-suppressive activities of SA1/STAG2 and effects of PARP impairment during brain development. | Disease models & mechanisms | 0 | 41502392 |
| 2026 | Analysis of STAG1 gene variants identified in a patient with intellectual disability and speech delay. | Yi chuan = Hereditas | 0 | 41669812 |
| 2025 | The synthetic TRPML1 agonist ML-SA1 mitigates intracellular lipid accumulation induced by antipsychotics in vitro by stimulating release of extracellular microvesicles. | Biochimica et biophysica acta. Molecular and cell biology of lipids | 0 | 40222411 |
| 2025 | STAG1 Disease, Central Precocious Puberty, and Bone Fragility-A Case Report. | Diagnostics (Basel, Switzerland) | 0 | 40361893 |
| 2025 | A Novel Variant of STAG1 Gene and Literature Review. | Annals of human genetics | 0 | 40899458 |
| 2025 | A novel frameshift STAG1 variant exhibiting haploinsufficiency due to the nonsense-mediated mRNA decay: a case report and literature review. | Frontiers in pediatrics | 0 | 41210242 |
| 1989 | [Immunochemical analysis of the products of translation of mRNA hybridized with the left HindIII-A-Sa1-fragment of vaccinia virus DNA]. | Molekuliarnaia genetika, mikrobiologiia i virusologiia | 0 | 2628751 |