Affinage

NOB1

RNA-binding protein NOB1 · UniProt Q9ULX3

Length
412 aa
Mass
46.7 kDa
Annotated
2026-06-10
68 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NOB1 is a conserved PIN-domain endonuclease that executes the final processing step of small ribosomal subunit biogenesis by cleaving pre-rRNA at site D to generate the mature 3'-end of 18S rRNA (PMID:15388878, PMID:22156373). Its catalytic PIN domain both binds the single-stranded D-site region and mediates manganese-dependent cleavage, with active-site point mutations abolishing 20S pre-rRNA processing in vivo and substrate cleavage in vitro (PMID:15388878, PMID:19801658, PMID:22156373); recombinant NOB1 binds directly to D-site-containing pre-rRNA analogs, positioning the active site over the cleavage site (PMID:19706509). A separate zinc ribbon domain, connected to the PIN domain by a flexible linker, anchors NOB1 to helix 40 of the small subunit rRNA on the nascent particle (PMID:22156373, PMID:21732055). Efficient in vivo D-site cleavage requires functional cooperation with the DEAH-box RNA helicase Prp43 and its cofactor Pfa1 (PMID:19801658), and proximity proteomics confirms NOB1 resides in an environment enriched for ribosome assembly, rRNA processing, and translation factors including EIF4B and EIF4G2 (PMID:40157618). Independently, in yeast NOB1 associates with the 19S regulatory particle of the 26S proteasome via Nin1p/Rpn12 and the ATPase Rpt1, acting as a chaperone for joining the 20S and 19S particles before being itself degraded (PMID:12502737, PMID:10675611). In multiple human cancer cell types, NOB1 loss-of-function suppresses proliferation and colony formation and promotes apoptosis, with its mRNA directly targeted by miR-326 and miR-215 and its expression positively regulated by eEF1A1 (PMID:23869222, PMID:30377124, PMID:28337275).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2000 Medium

    Established the first physical context for Nob1p, placing it in the 26S proteasome rather than predicting an RNA-processing role.

    Evidence Two-hybrid screen, reciprocal co-IP, and glycerol gradient fractionation in yeast

    PMID:10675611

    Open questions at the time
    • Did not establish a catalytic activity
    • Did not address rRNA processing
    • Mechanism of proteasome association unresolved
  2. 2002 Medium

    Assigned Nob1p a chaperone role in 26S proteasome assembly, defining a function distinct from any ribosomal activity.

    Evidence ts mutants, overexpression rescue, co-fractionation, immunolocalization, and proteasome assembly assays in yeast

    PMID:12502737

    Open questions at the time
    • Relationship between proteasome and rRNA roles not reconciled
    • Direct enzymatic mechanism not shown
    • Conservation of proteasome role to humans untested
  3. 2004 High

    Identified the PIN domain as the catalytic module required for D-site cleavage of pre-rRNA, recasting NOB1 as the 18S rRNA 3'-end maturation endonuclease.

    Evidence Homology modeling plus active-site mutagenesis with in vivo pre-rRNA processing readout in yeast

    PMID:15388878

    Open questions at the time
    • Direct in vitro cleavage not yet demonstrated
    • Metal dependence inferred from homology only
    • Substrate-binding determinants undefined
  4. 2009 High

    Demonstrated direct, sequence-specific binding of NOB1 to the D-site region and reconstituted cleavage in vitro, linking binding geometry to catalysis.

    Evidence Recombinant protein binding, RNA truncation/footprinting, and in vitro endonuclease assays with PIN mutants, plus genetic epistasis with Prp43/Pfa1

    PMID:19706509 PMID:19801658

    Open questions at the time
    • Trigger for activation within the pre-40S particle unclear
    • Precise role of Prp43 helicase activity in cleavage not defined
    • Tetramer relevance in vivo uncertain
  5. 2011 High

    Resolved the two-domain architecture, showing the PIN domain handles substrate binding/cleavage and a separate zinc ribbon anchors NOB1 to helix 40, and established manganese dependence.

    Evidence NMR structure, resonance assignments, in vitro cleavage, and domain dissection of the archaeal Pyrococcus horikoshii homolog

    PMID:21732055 PMID:22156373

    Open questions at the time
    • Structure of the human enzyme not determined
    • Conformational activation switch not captured
    • Interplay of the two domains during catalysis on a real particle unresolved
  6. 2018 Medium

    Connected NOB1 to cancer cell phenotypes, showing miRNA control of its 3'-UTR and eEF1A1-dependent regulation modulate proliferation, apoptosis, and invasion.

    Evidence Luciferase 3'-UTR reporters (miR-326, miR-215), knockdown/overexpression with rescue, and migration/invasion assays across glioma, ovarian, and hepatocellular carcinoma cells

    PMID:23869222 PMID:28337275 PMID:30377124

    Open questions at the time
    • Whether phenotypes depend on NOB1 catalytic/ribosomal function untested
    • Direct effectors downstream of NOB1 not defined
    • Causal link from rRNA processing defect to apoptosis unestablished
  7. 2025 Medium

    Defined the human NOB1 proximity interactome, anchoring it in ribosome assembly, rRNA processing, and translation and validating direct contacts with translation factors.

    Evidence TurboID proximity labeling with mass spectrometry, co-IP validation (EIF4B, EIF4G2), and immunofluorescence comparison with PNO1

    PMID:40157618

    Open questions at the time
    • Functional consequence of EIF4B/EIF4G2 contacts unknown
    • Proximity does not establish stable complex membership
    • Human D-site cleavage activity not directly assayed here

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NOB1's catalytic role in 18S rRNA maturation mechanistically connects to its observed proliferation/apoptosis phenotypes and signaling-pathway associations in human cancer cells remains unresolved.
  • No study links NOB1 endonuclease activity to MAPK/JNK signaling readouts
  • Pathway placements rest on phospho-protein levels without epistasis
  • No human structural or reconstituted cleavage data

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 4 GO:0016787 hydrolase activity 3 GO:0003723 RNA binding 2
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 1
Pathway
R-HSA-8953854 Metabolism of RNA 5
Partners
EIF4BEIF4G2PFA1PNO1PRP43RPN12RPT1
Complex memberships
26S proteasome (19S regulatory particle)pre-40S ribosomal subunit

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 The PIN domain of Nob1p is required for D-site cleavage of 20S pre-rRNA to generate mature 18S rRNA. A homology model of the PIN domain revealed structural mimicry of Mg2+-dependent exonucleases, and a point mutation predicted to abolish enzymatic activity abolished 20S pre-rRNA cleavage in vivo. Homology modeling, site-directed mutagenesis, in vivo pre-rRNA processing assay RNA High 15388878
2009 Recombinant yeast Nob1 forms a tetramer that binds directly to pre-rRNA analogs containing the D-site cleavage region. RNA truncation and footprinting analyses showed Nob1's binding site centers around the single-stranded 3'-end of 18S rRNA, co-localizing with the proposed active site, positioning Nob1 for cleavage at site D. Recombinant protein binding assays, RNA truncation series, in vitro and in vivo Nob1-dependent RNA protection assays Proceedings of the National Academy of Sciences of the United States of America High 19706509
2009 In vivo cleavage of yeast pre-rRNA at site D requires functional interaction between the PIN domain endonuclease Nob1 and the DEAH-box RNA helicase Prp43 and its cofactor Pfa1. Nob1 cleaved a D-site substrate analogue in vitro; mutations in the Nob1 PIN domain or RNA substrate abolished this cleavage. Genetic epistasis showed that increased dosage of wild-type Nob1, but not catalytic-site mutants, suppressed 20S pre-rRNA accumulation caused by ltv1/pfa1 mutations. In vitro endonuclease assay with PIN domain mutants, genetic epistasis (suppressor dosage analysis), in vivo pre-rRNA processing analysis The Journal of biological chemistry High 19801658
2011 The archaeal (Pyrococcus horikoshii) Nob1 homolog efficiently cleaves RNA substrates containing the D-site of pre-ribosomal RNA in a manganese-dependent manner. NMR structure revealed a PIN domain (required for substrate binding) connected by a flexible linker to a zinc ribbon domain that binds helix 40 of the small subunit rRNA and acts as an anchor on the nascent subunit. In vitro RNA cleavage assay, NMR structure determination, domain mutagenesis/deletion analysis Nucleic acids research High 22156373
2002 Yeast Nob1p forms a complex with the 19S regulatory particle of the 26S proteasome and with nuclear protein Pno1p. Temperature-sensitive nob1 mutants show defects in beta-subunit processing and 20S/26S proteasome assembly. Nob1p acts as a chaperone to join the 20S proteasome with the 19S regulatory particle in the nucleus, facilitate Ump1p degradation, and is then itself internalized and degraded to complete 26S proteasome biogenesis. Genetic analysis (ts mutants), overexpression rescue, co-fractionation, immunolocalization, proteasome assembly assays Genes & development Medium 12502737
2000 Nob1p interacts with Nin1p/Rpn12 (a 19S regulatory particle subunit) of the yeast 26S proteasome as identified by two-hybrid screening, and co-immunoprecipitates with the ATPase component Rpt1. Nob1p is found exclusively in proteasomal fractions on glycerol gradients, and is degraded by the 26S proteasome during transition to stationary phase. Two-hybrid screening, glycerol gradient fractionation, co-immunoprecipitation, Western blot Gene Medium 10675611
2005 The human NOB1 protein contains a PIN domain and a zinc ribbon domain. When expressed in mammalian culture cells, the NOB1 protein is mainly localized to the nucleus. Cloning, sequence analysis, Western blot, subcellular localization by imaging of expressed protein Molecular biology reports Low 16172919
2011 NOB1 is an archaeal/eukaryotic endonuclease with a PIN domain (residues required for substrate binding) and a zinc ribbon domain sufficient to bind helix 40 of the small subunit rRNA; NMR resonance assignments for the archaeal PhNob1 were determined as a structural prerequisite. NMR resonance assignment (backbone and side chain) Biomolecular NMR assignments Medium 21732055
2013 miR-326 directly targets the 3'-UTR of human NOB1 mRNA (validated by luciferase reporter assay), reducing NOB1 protein levels. NOB1 silencing in glioma cells (shRNA) causes G1 cell cycle arrest, reduced proliferation, enhanced apoptosis, and decreased colony formation, phenocopying miR-326 overexpression. NOB1 overexpression partially rescues miR-326-mediated growth inhibition. These effects involve the MAPK pathway. Dual-luciferase reporter assay (3'-UTR targeting), shRNA knockdown, cell cycle analysis, apoptosis assay, colony formation, xenograft model PloS one Medium 23869222
2016 NOB1 silencing in laryngeal cancer cells inhibits proliferation, induces cell cycle arrest and apoptosis, and inhibits migration and invasion with downregulation of MMP-2 and MMP-9. Mechanistically, NOB1 silencing activates the JNK signaling pathway. siRNA knockdown, proliferation/apoptosis/migration assays, Western blot (MMP-2/9, JNK pathway) Oncology reports Low 27035645
2014 Downregulation of NOB1 in papillary thyroid carcinoma cells by RNAi significantly activates constitutive phosphorylation of p38 MAPK, which may contribute to inhibition of cancer cell growth and enhances radiosensitivity in vitro and in vivo. Adenovirus-mediated siRNA, clonogenic survival assay, xenograft model, Western blot (p38 MAPK phosphorylation) Oncology reports Low 25231838
2018 eEF1A1 positively regulates NOB1 expression (mRNA and protein) in hepatocellular carcinoma cells. Knockdown of eEF1A1 reduces NOB1 expression and decreases HCC cell invasion and migration; eEF1A1 overexpression increases NOB1 expression and promotes invasion/migration. Restoring NOB1 in eEF1A1-knockdown cells rescues invasion/migration, while NOB1 knockdown in eEF1A1-overexpressing cells reverses the enhanced invasion/migration. siRNA knockdown, overexpression, qRT-PCR, Western blot, Transwell invasion/migration assays, RTCA assay, epistasis by rescue experiment Nan fang yi ke da xue xue bao = Journal of Southern Medical University Medium 30377124
2014 NOB1 knockdown in osteosarcoma cells (U2OS) decreases cell migration and increases E-cadherin and β-catenin expression, suggesting NOB1 suppresses these epithelial markers to promote migration. Lentiviral shRNA knockdown, Transwell migration assay, Western blot (E-cadherin, β-catenin) Molecular medicine reports Low 24714960
2025 TurboID proximity labeling identified 1044 proximal proteins for NOB1 (and 871 for PNO1), with 663 overlapping. NOB1 and PNO1 have different intracellular localizations (immunofluorescence). Co-IP validated interactions of both NOB1 and PNO1 with translation-related proteins EIF4B and EIF4G2. Proximal proteins are predominantly enriched in ribosome assembly, rRNA processing, and translation. TurboID proximity labeling, mass spectrometry, co-immunoprecipitation, immunofluorescence Gene Medium 40157618
2020 NOB1 silencing in colorectal cancer cells increases phosphorylation of JNK, ERK, and p38, suppresses proliferation and colony formation, and promotes apoptosis, placing NOB1 upstream of the JNK signaling pathway in these cells. siRNA knockdown, MTT assay, colony formation, flow cytometry, Western blot (phospho-JNK, -ERK, -p38) Journal of investigative surgery Low 31906747
2017 miR-215 directly targets the 3'-UTR of NOB1 mRNA in epithelial ovarian cancer cells (validated by luciferase reporter assay), suppressing NOB1 expression. NOB1 suppression activates the MAPK signaling pathway. NOB1 overexpression rescues the anti-tumor effects of miR-215. Dual-luciferase reporter assay, miRNA mimic transfection, Western blot (MAPK), rescue overexpression American journal of translational research Low 28337275
2015 NOB1 knockdown in ovarian cancer cells upregulates DR5 expression and activates the MAPK pathway, increasing sensitivity to TRAIL-induced apoptosis, including increased caspase-3, -8, and -9 activity. Lentiviral shRNA knockdown, TRAIL combination treatment, caspase activity assays, Western blot (DR5, MAPK), xenograft model International journal of clinical and experimental pathology Low 26617713

Source papers

Stage 0 corpus · 68 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1. The Journal of biological chemistry 161 19801658
2009 Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain. Proceedings of the National Academy of Sciences of the United States of America 123 19706509
2004 PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA. RNA (New York, N.Y.) 107 15388878
2017 Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma. International journal of oncology 91 29115574
2002 Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Genes & development 79 12502737
2013 MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1). PloS one 75 23869222
2016 miR-326 Inhibits Gastric Cancer Cell Growth Through Downregulating NOB1. Oncology research 66 27733214
2014 Downregulated miR-646 in clear cell renal carcinoma correlated with tumour metastasis by targeting the nin one binding protein (NOB1). British journal of cancer 65 25010867
2016 MiR-139-3p induces cell apoptosis and inhibits metastasis of cervical cancer by targeting NOB1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 63 27505862
2011 Structural and functional analysis of the archaeal endonuclease Nob1. Nucleic acids research 62 22156373
2000 Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice. Diabetologia 56 11151768
2011 RNAi-mediated downregulation of NOB1 suppresses the growth and colony-formation ability of human ovarian cancer cells. Medical oncology (Northwood, London, England) 52 21287298
2000 Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells. Gene 47 10675611
2002 Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 43 12107726
2005 Cloning, expression and characterization of the human NOB1 gene. Molecular biology reports 41 16172919
2019 LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis. Frontiers in pharmacology 33 31068824
2017 MicroRNA-215 targets NOB1 and inhibits growth and invasion of epithelial ovarian cancer. American journal of translational research 31 28337275
2016 High Expression of RIOK2 and NOB1 Predict Human Non-small Cell Lung Cancer Outcomes. Scientific reports 31 27346559
2017 Inhibition of NOB1 by microRNA-330-5p overexpression represses cell growth of non-small cell lung cancer. Oncology reports 27 28849232
2020 MicroRNA-612 inhibits cervical cancer progression by targeting NOB1. Journal of cellular and molecular medicine 24 31970934
2018 miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1. International journal of oncology 23 29749434
2017 MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1. Oncotarget 21 29254193
2017 Low-level miR-646 in colorectal cancer inhibits cell proliferation and migration by targeting NOB1 expression. Oncology letters 21 29391877
2013 Expression of the NOB1 gene and its clinical significance in papillary thyroid carcinoma. The Journal of international medical research 20 23685895
2018 microRNA-744 is downregulated in glioblastoma and inhibits the aggressive behaviors by directly targeting NOB1. American journal of cancer research 19 30555741
2019 Long non-coding RNA ZFAS1 regulates NOB1 expression through interacting with miR-646 and promotes tumorigenesis in osteosarcoma. European review for medical and pharmacological sciences 18 31081072
2015 NOB1 is essential for the survival of RKO colorectal cancer cells. World journal of gastroenterology 18 25624720
2013 Clinical significance of NOB1 expression in breast infiltrating ductal carcinoma. International journal of clinical and experimental pathology 18 24133592
2020 MicroRNA-363-3p downregulation in papillary thyroid cancer inhibits tumor progression by targeting NOB1. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 17 33077486
2014 Downregulation of NOB1 suppresses the proliferation and tumor growth of non-small cell lung cancer in vitro and in vivo. Oncology reports 16 24452698
2014 Knockdown of NOB1 expression inhibits the malignant transformation of human prostate cancer cells. Molecular and cellular biochemistry 15 25169742
2020 MiR-363 suppresses cell migration, invasion, and epithelial-mesenchymal transition of osteosarcoma by binding to NOB1. World journal of surgical oncology 14 32357945
2016 NOB1 silencing inhibits the growth and metastasis of laryngeal cancer cells through the regulation of JNK signaling pathway. Oncology reports 14 27035645
2014 Adenovirus-mediated siRNA targeting NOB1 inhibits tumor growth and enhances radiosensitivity of human papillary thyroid carcinoma in vitro and in vivo. Oncology reports 14 25231838
2013 Knockdown of NOB1 expression by RNAi inhibits cellular proliferation and migration in human gliomas. Gene 14 23911301
2022 The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo. PLoS genetics 13 35500030
2011 Up-regulation of Nob1 in the rat auditory system with noise-induced hearing loss. Neuroscience letters 13 21219967
2015 Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo. Oncology reports 12 25592304
2014 Gene silencing of NOB1 by lentivirus suppresses growth and migration of human osteosarcoma cells. Molecular medicine reports 12 24714960
2014 Lentivirus-mediated knockdown of NOB1 suppresses the proliferation of colon cancer cells. Zeitschrift fur Gastroenterologie 11 24824907
2008 Preparation and characterization of a novel monoclonal antibody specific to human NOB1 protein. Hybridoma (2005) 10 18582212
2019 NOB1: A Potential Biomarker or Target in Cancer. Current drug targets 8 30854959
2008 The expression of NOB1 in spiral ganglion cells of guinea pig. International journal of pediatric otorhinolaryngology 8 19101043
2022 Overexpression of microRNA-107 suppressed proliferation, migration, invasion, and the PI3K/Akt signaling pathway and induced apoptosis by targeting Nin one binding (NOB1) protein in a hypopharyngeal squamous cell carcinoma cell line (FaDu). Bioengineered 7 35294329
2018 Effects of NOB1 on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin. Oncology letters 7 29467874
2016 NOB1 expression predicts early response to cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer. Journal of chemotherapy (Florence, Italy) 7 25971309
2015 Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma. Oncology reports 7 26370469
2015 Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells. International journal of clinical and experimental pathology 7 26617713
1999 Analysis of interleukin (IL)-1 beta and transforming growth factor (TGF)-beta-induced signal transduction pathways in IL-2 and TGF-beta secretion and proliferation in the thymoma cell line EL4.NOB-1. Scandinavian journal of immunology 7 10075017
2020 Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer. Journal of investigative surgery : the official journal of the Academy of Surgical Research 6 31906747
2023 Partner of NOB1 homolog transcriptionally activated by E2F transcription factor 1 promotes the malignant progression and inhibits ferroptosis of pancreatic cancer. The Chinese journal of physiology 5 37929351
2019 MicroRNA‑744 suppresses cell proliferation and invasion of papillary thyroid cancer by directly targeting NOB1. Molecular medicine reports 5 30628685
2015 Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation. Oncology reports 5 26178254
2012 [Expression of NOB1 and its significance in colorectal cancer]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 5 22445998
2021 Integrated Analysis of the m6A-Related lncRNA Identified lncRNA ABALON/miR-139-3p/NOB1 Axis Was Involved in the Occurrence of Lung Cancer. Cancer management and research 4 34849026
2015 EXPRESSION MECHANISM AND CLINICAL SIGNIFICANCE OF NOB1 IN GASTRIC CANCER TISSUE AND ADJACENT NORMAL TISSUE. Journal of biological regulators and homeostatic agents 4 26122232
2011 Backbone and side chain NMR resonance assignments for an archaeal homolog of the endonuclease Nob1 involved in ribosome biogenesis. Biomolecular NMR assignments 4 21732055
1991 Biological assays for interleukin 1 detection. Comparison of human T lymphocyte, murine thymocyte and NOB-1 assays. Allergy 4 2018210
2020 [Retracted] Downregulation of NOB1 suppresses the proliferation and tumor growth of non‑small cell lung cancer in vitro and in vivo. Oncology reports 3 32020218
2012 [Effect of lentivirus-mediated NOB1 gene silencing by RNA interference on proliferation and apoptosis of human colon cancer cells]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 3 23172535
2018 [Eukaryotic translation elongation factor 1A1 positively regulates NOB1 expression to promote invasion and metastasis of hepatocellular carcinoma cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2 30377124
2024 Ribosome Biogenesis and Cancer: Insights into NOB1 and PNO1 Mechanisms. Current pharmaceutical design 1 39143880
2022 miRNA-612 suppresses ovarian cancer cell tumorigenicity by downregulating NOB1. American journal of translational research 1 35836846
2022 [Corrigendum] Gene silencing of NOB1 by lentivirus suppresses growth and migration of human osteosarcoma cells. Molecular medicine reports 1 36484386
2016 Establishment of a Novel Monoclonal Antibody L6 Specific to NOB1. Monoclonal antibodies in immunodiagnosis and immunotherapy 1 27097067
2025 The proximity proteome of pre-40S pre-ribosomal particle components PNO1 and NOB1 using turboID proximity labeling technology. Gene 0 40157618
2023 [Retracted] MicroRNA‑744 suppresses cell proliferation and invasion of papillary thyroid cancer by directly targeting NOB1. Molecular medicine reports 0 37594052
2022 Expression and distribution of Nob1 in the developing rat cochleae. Gene expression patterns : GEP 0 35288316

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