Affinage

MTBP

Mdm2-binding protein · UniProt Q96DY7

Length
904 aa
Mass
102.2 kDa
Annotated
2026-06-10
40 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MTBP is a multifunctional regulator that operates at the intersection of DNA replication initiation, p53 homeostasis, and cell migration control. Its best-characterized role is as the essential metazoan partner of TRESLIN, with which it forms an elongated tetramer (two copies of each protein) that is rate-limiting for replication origin firing; depletion of MTBP abolishes DNA replication in Xenopus egg extracts and can only be rescued by the reconstituted TRESLIN-MTBP complex (PMID:28877985, PMID:34699733). A C-terminal Sld7-homologous CTM domain binds double-stranded and G-quadruplex DNA and is required for chromatin localization and CDC45 loading (PMID:28877985), and genome-wide the complex associates with tens of thousands of open-chromatin regulatory elements bearing G4 motifs, AP-1 sites, and H3K4me2 nucleosomes (PMID:32966791). MTBP loading onto phosphorylated MCM2-7 double hexamers is governed by opposing phosphorylation: CDK and DDK promote, while RIF1-PP1 opposes, thereby setting initiation zones and replication timing (PMID:41331242), and direct CDK phosphorylation of MTBP at activating versus checkpoint-kinase sites tunes origin firing capacity in either direction (PMID:33608586). By acting transiently at pre-replication complexes and being released after CDC45 recruitment, TRESLIN-MTBP also implements a checkpoint-independent monitoring system that prevents premature S/G2 transition (PMID:36049481). Independently, MTBP promotes MDM2-mediated ubiquitination and degradation of p53 while stabilizing MDM2, contributing to p53 homeostasis (PMID:15632057), and it has an essential p53-independent developmental function, as Mtbp-null mice die early in embryogenesis irrespective of p53 status (PMID:17906694). MTBP suppresses cell migration and metastasis by binding and inhibiting the actin-bundling protein ACTN4 (PMID:22370640) and by sequestering importin-7/IPO7 to block nuclear import of phospho-Erk1/2 (PMID:29765550). It additionally serves as a transcriptional co-activator, associating with MYC cofactors TIP48/TIP49 at MYC-bound promoters to drive transformation (PMID:24786788) and enhancing ETS-1 recruitment to target promoters (PMID:36106099). A distinct mitotic role involves transient kinetochore localization and recruitment of Mad1/Mad2 during prometaphase, with MTBP degradation required for checkpoint silencing (PMID:21274008).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2000 Medium

    Established MTBP as a physical and functional partner of MDM2, defining its first molecular context as a growth-regulatory factor.

    Evidence Yeast two-hybrid screen and cell cycle analysis identifying MTBP and MDM2-suppressible G1 arrest

    PMID:10906133

    Open questions at the time
    • Mechanism of MTBP-induced G1 arrest not defined
    • Binding interface with MDM2 not mapped
  2. 2005 High

    Resolved how MTBP feeds into the p53 pathway, showing it potentiates MDM2 ligase function rather than merely binding it.

    Evidence siRNA knockdown, in vitro ubiquitination assays, and MDM2 RING finger mutants with Western blotting

    PMID:15632057

    Open questions at the time
    • Whether MTBP is a direct ubiquitination substrate or only a cofactor
    • Structural basis of MDM2 stabilization unresolved
  3. 2007 High

    Demonstrated MTBP has an essential developmental role separable from p53 and a haploinsufficient tumor-suppressive/anti-metastatic function in vivo.

    Evidence Mtbp knockout and haploinsufficient mouse models with in vivo tumor/metastasis and in vitro invasion assays

    PMID:17906694

    Open questions at the time
    • Molecular identity of the essential embryonic function not defined
    • Mechanism linking MTBP loss to increased metastasis not yet established
  4. 2011 High

    Identified a mitotic checkpoint role, showing MTBP is needed for Mad1/Mad2 kinetochore recruitment and that its timed degradation permits checkpoint silencing.

    Evidence Immunofluorescence, live-cell imaging, siRNA knockdown and overexpression with flow cytometry

    PMID:21274008

    Open questions at the time
    • Direct binding partners at the kinetochore not identified
    • Relationship between mitotic and replication functions unclear
  5. 2012 High

    Provided a biochemical mechanism for MTBP's anti-migratory activity through direct inhibition of ACTN4-mediated actin bundling.

    Evidence Reciprocal Co-IP and mass spectrometry, F-actin bundling assays, and migration assays

    PMID:22370640

    Open questions at the time
    • ACTN4-binding region of MTBP not mapped
    • Regulation of the cytoplasmic MTBP pool not defined
  6. 2014 High

    Linked MTBP to oncogenic transcription, showing it associates with MYC cofactors TIP48/TIP49 at MYC promoters to amplify MYC-driven transformation.

    Evidence Co-IP, ChIP at MYC-bound promoters, transcriptional and transformation assays, in vivo tumor models

    PMID:24786788

    Open questions at the time
    • Whether MTBP contacts MYC directly or only via TIP48/TIP49 unresolved
    • Reconciliation with tumor-suppressive functions not addressed
  7. 2015 Medium

    Proposed an EMT-promoting mechanism via MDM2-dependent E-cadherin degradation in HCC.

    Evidence Western blotting, knockdown/overexpression, migration/invasion and in vivo metastasis assays

    PMID:26280083

    Open questions at the time
    • No direct biochemical reconstitution of MDM2-mediated E-cadherin ubiquitination
    • Apparent conflict with anti-metastatic findings unaddressed
  8. 2017 High

    Defined MTBP's core replication function, establishing the DNA-binding CTM domain and the obligate TRESLIN-MTBP complex as essential for CDC45 loading and origin firing.

    Evidence Xenopus egg extract depletion/add-back, DNA-binding assays, CTM domain mutagenesis, and chromatin fractionation in human cells

    PMID:28877985

    Open questions at the time
    • Structure of the CTM-DNA interaction not solved
    • Sequence determinants of genomic site selection not defined
  9. 2018 Medium

    Added a signaling mechanism for metastasis suppression, showing MTBP blocks IPO7-mediated nuclear import of phospho-Erk1/2 to dampen Elk-1 transcription.

    Evidence Co-IP, reporter signal arrays, phosphorylation assays, immunofluorescence, and clinical tissue analysis

    PMID:29765550

    Open questions at the time
    • IPO7-binding interface not mapped
    • Single-lab Co-IP without reconstitution of the import-blocking step
  10. 2020 Medium

    Mapped where TRESLIN-MTBP acts genome-wide, revealing preferential association with open-chromatin regulatory elements and specific DNA/nucleosome signals.

    Evidence ChIP-seq and chromatin accessibility analysis in human cells

    PMID:32966791

    Open questions at the time
    • Causal link between individual binding signals and firing not dissected
    • Functional outcome at each site class not measured
  11. 2021 Medium

    Established MTBP as a phospho-regulated platform integrating activating CDK signals and inhibitory checkpoint-kinase signals to set origin-firing levels.

    Evidence Phospho-mimetic and non-phosphorylatable mutants with origin firing and DNA damage response assays in human cells

    PMID:33608586

    Open questions at the time
    • Identities of all responsible kinases not fully defined
    • How phospho-states alter chromatin loading mechanistically unresolved
  12. 2021 High

    Defined the architecture and kinase-dependent activation of the complex, showing TRESLIN-MTBP is a rate-limiting tetramer whose chromatin and TopBP1 engagement is driven by DDK and CDK.

    Evidence Xenopus egg extract depletion/add-back, complex stoichiometry analysis, and kinase inhibitor experiments

    PMID:34699733

    Open questions at the time
    • High-resolution structure of the tetramer not determined
    • Order of DDK and CDK inputs not fully ordered
  13. 2022 High

    Revealed a checkpoint-independent surveillance role, showing transient TRESLIN-MTBP action at preRCs monitors origin firing rate to prevent premature S/G2 transition.

    Evidence Cell synchronization, protein depletion/add-back, ChIP, and kinase inhibitor experiments

    PMID:36049481

    Open questions at the time
    • Molecular sensor reading the firing-rate decline not identified
    • Downstream effector enforcing S/G2 timing unknown
  14. 2022 Medium

    Extended the transcriptional co-activator role to ETS-1, showing MTBP enhances ETS-1 promoter recruitment to drive HCC proliferation.

    Evidence Luciferase reporters, qPCR, ChIP, knockdown/overexpression, and xenograft models

    PMID:36106099

    Open questions at the time
    • Direct MTBP-ETS-1 contact versus indirect bridging not resolved
    • Generality beyond the mmp1 promoter untested
  15. 2025 High

    Placed MTBP loading at the center of replication timing control, showing opposing DDK and RIF1-PP1 phosphorylation events set initiation zones.

    Evidence Genome-wide firing-factor mapping, auxin-inducible degron, and kinase/phosphatase manipulation with chromatin fractionation

    PMID:41331242

    Open questions at the time
    • Direct phosphosites on MCM-DH targeted by this regulation not enumerated
    • Quantitative threshold determining IZ selection unresolved
  16. 2025 Medium

    Distinguished two chromatin-binding modes, showing MTBP requires TRESLIN for G1 association but binds independently in S phase, diverging from the yeast Sld3-Sld7 paradigm.

    Evidence CUT&RUN with G1 synchronization, Geminin-mediated licensing inhibition, and siRNA knockdown

    PMID:40624716

    Open questions at the time
    • Determinants of licensing-independent G1 binding unknown
    • Functional purpose of pre-licensing chromatin association unclear
  17. 2025 Medium

    Identified a kinase-activating function, showing MTBP allosterically activates and targets Cdk8/19-CycC to Med12-independent roles including origin firing.

    Evidence In vitro kinase assays, structural analysis, and mutagenesis (preprint)

    PMID:bio_10.1101_2025.06.16.659917

    Open questions at the time
    • Preprint not yet peer-reviewed
    • In vivo contribution of MTBP-Cdk8/19 to origin firing not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MTBP's distinct functions in replication initiation, p53/MDM2 control, migration suppression, transcriptional co-activation, and mitotic checkpoint signaling are coordinated within a single cell remains unresolved.
  • No unified model connecting nuclear replication roles with cytoplasmic anti-migratory roles
  • Whether distinct functions reflect separable protein pools or domains not determined
  • Reconciliation of tumor-suppressive versus oncogenic activities unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3 GO:0003677 DNA binding 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005694 chromosome 3 GO:0005634 nucleus 2 GO:0005829 cytosol 2
Pathway
R-HSA-69306 DNA Replication 3 R-HSA-1640170 Cell Cycle 2 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-392499 Metabolism of proteins 1
Partners
ACTN4CDK8IPO7MDM2TIP48TIP49TOPBP1TRESLIN
Complex memberships
TRESLIN-MTBP complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 MTBP (MDM2-binding protein) was identified as a novel MDM2-binding protein via yeast two-hybrid screen. MTBP induces G1 arrest that is suppressed by MDM2, establishing MTBP as a target of MDM2-mediated growth inhibition. Yeast two-hybrid screen, cell cycle analysis The Journal of biological chemistry Medium 10906133
2005 MTBP promotes MDM2-mediated ubiquitination and proteasomal degradation of p53 in an MDM2 RING finger-dependent manner, and also stabilizes MDM2. siRNA knockdown of endogenous MTBP increases p53 levels and activity, demonstrating MTBP significantly contributes to MDM2-dependent p53 homeostasis. Following UV (but not gamma-irradiation), MTBP is destabilized as part of the stress response. siRNA knockdown, ubiquitination assays, MDM2 RING finger mutants, Western blotting Molecular and cellular biology High 15632057
2007 Homozygous deletion of Mtbp in mice causes early embryonic lethality that is not rescued by p53 loss, indicating an essential p53-independent developmental function. Mtbp haploinsufficiency in p53+/- background significantly increases metastatic tumors in vivo, and Mtbp loss increases invasion/migration in osteosarcoma cells, while MTBP overexpression inhibits invasiveness. Knockout mouse model, in vivo tumor studies, in vitro migration/invasion assays Oncogene High 17906694
2011 MTBP protein is rapidly degraded during mitosis. A portion of MTBP localizes at kinetochores during prometaphase. MTBP overexpression delays mitotic progression and induces abnormal chromosome segregation, while MTBP downmodulation causes abbreviated metaphase, insufficient mitotic arrest, aneuploidy, and cell death. MTBP is required for accumulation of Mad1 and Mad2 (but not BubR1) at kinetochores during prometaphase, and MTBP degradation is required for mitotic checkpoint silencing. Immunofluorescence, live-cell imaging, siRNA knockdown, overexpression, flow cytometry Cell death and differentiation High 21274008
2012 MTBP interacts endogenously with alpha-actinin-4 (ACTN4), identified by Co-IP and mass spectrometry. MTBP overexpression inhibits ACTN4-mediated cell migration and filopodia formation. MTBP also inhibits ACTN4-mediated F-actin bundling. Nuclear localization of MTBP is dispensable for inhibiting ACTN4-mediated migration, indicating cytoplasmic MTBP mediates this function. Co-immunoprecipitation, mass spectrometry, overexpression/knockdown, migration assays, F-actin bundling assay, immunofluorescence Oncogene High 22370640
2014 MTBP binds to MYC transcriptional cofactors TIP48 and TIP49, and indirectly associates with MYC in a complex at MYC-bound promoters. MTBP increases MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. TIP48/TIP49 associations as well as MYC are implicated in MTBP's function in cellular transformation. Co-immunoprecipitation, chromatin immunoprecipitation, transcriptional assays, transformation assays, in vivo tumor models Cancer research High 24786788
2015 MTBP overexpression in HCC cells decreases E-cadherin expression through MDM2 ubiquitination-mediated degradation of E-cadherin, promoting epithelial-to-mesenchymal transition and invasion. Western blotting, siRNA knockdown, overexpression, migration/invasion assays, in vivo metastasis model Digestive diseases and sciences Medium 26280083
2017 MTBP contains a C-terminal domain (CTM domain) homologous to budding yeast Sld7 that binds efficiently to double-stranded DNA and G-quadruplex (G4) DNA. Depletion of MTBP from Xenopus egg extracts (which also removes Treslin) abolishes DNA replication; replication is rescued only by recombinant Treslin-MTBP complex, not by either protein alone. CTM domain mutants are defective in chromatin localization, fail to support Cdc45 loading, and cause severe S-phase defects in human cells. Xenopus egg extract depletion/add-back, DNA-binding assays, site-directed mutagenesis, chromatin fractionation, flow cytometry Molecular biology of the cell High 28877985
2018 MTBP inhibits nuclear translocation of phosphorylated Erk1/2 (p-Erk) by binding to importin-7/RanBP7 (IPO7), an importin that shuttles p-Erk into the nucleus, thereby suppressing Elk-1 phosphorylation and transcriptional activity of Elk-1 target genes. This identifies a mechanism by which MTBP suppresses HCC metastasis via the Erk1/2-Elk-1 signaling pathway. Luciferase reporter signal array, Co-IP, phosphorylation assays, mRNA expression analysis, immunofluorescence, clinical tissue analysis Oncotarget Medium 29765550
2020 The MTBP subunit of the Treslin-MTBP complex binds at least 30,000 sites in the human genome, predominantly in regions of open chromatin containing transcriptional regulatory elements (promoters, enhancers, super-enhancers). Many binding sites encompass nucleosome-free DNA sequences (e.g., G-quadruplex DNA or AP-1 motif) and nucleosomes bearing H3K4me2 marks, indicating Treslin-MTBP associates coordinately with multiple genomic signals to promote replication initiation. ChIP-seq, genome-wide mapping, chromatin accessibility analysis Cell reports Medium 32966791
2021 MTBP is phosphorylated at CDK consensus sites by cell cycle CDKs and Cdk8/19-cyclin C; phospho-mimetic CDK site mutants promote origin firing in human cells while non-phosphorylatable mutants do not. MTBP is also phosphorylated at DNA damage checkpoint kinase consensus sites; phospho-mimetic mutations at these sites inhibit origin firing capability. A non-phospho MTBP mutant induces genome-wide increase of origin firing in unperturbed cells, establishing MTBP as a regulatory platform for metazoan origin firing. Phospho-mimetic and non-phosphorylatable mutant expression, origin firing assays in human cells, DNA damage response assays Scientific reports Medium 33608586
2021 MTBP forms an elongated tetramer with Treslin in Xenopus egg extract, containing two molecules of each protein. Treslin-MTBP is rate-limiting for replication initiation. DDK activity both increases and strengthens the interaction of Treslin-MTBP with licensed chromatin. DDK activity cooperates with CDK activity to drive the interaction of Treslin-MTBP with TopBP1, a key regulated step in pre-initiation complex formation. Xenopus egg extract immunodepletion/add-back, biochemical fractionation, complex analysis, kinase inhibitor experiments Open biology High 34699733
2022 The TRESLIN-MTBP complex acts transiently at pre-replication complexes (preRCs) to initiate origin firing and is released after CDC45 recruitment. This dynamic behavior implements a monitoring system detecting the rate of origin firing to prevent premature entry into G2. TRESLIN-MTBP prevents premature S/G2 transition independently of ATR/CHK1 kinases, sensing the natural decline in origin firing in late S phase. Cell synchronization, flow cytometry, protein depletion/add-back, ChIP, kinase inhibitor experiments Molecular cell High 36049481
2022 MTBP functions as a co-activator of transcription factor ETS-1, enhancing its transcriptional activity and promoting recruitment of ETS-1 to the mmp1 promoter, thereby promoting HCC cell proliferation. Luciferase reporter assays, qPCR, chromatin immunoprecipitation, overexpression/knockdown, xenograft models Frontiers in oncology Medium 36106099
2025 MTBP is a limiting firing factor for replication initiation whose loading onto phosphorylated MCM2-7 double hexamer (MCM-DH) is controlled by opposing phosphorylation events: Dbf4-dependent kinase (DDK) promotes and RIF1-Protein Phosphatase 1 opposes TRESLIN-MTBP loading, ultimately determining initiation zones (IZs) and replication timing (RT). Genome-wide mapping of firing factors, auxin-inducible degron (AID) system, kinase/phosphatase manipulation, chromatin fractionation Nature communications High 41331242
2025 MTBP is dependent on TRESLIN for proper chromatin association during G1, but not during S phase, indicating two separate modes of chromatin binding. TRESLIN and MTBP binding to chromatin during G1 does not require licensed origins (loaded MCMs), diverging from yeast Sld3-Sld7 mechanism. CUT&RUN genomic binding assay, Geminin overexpression to inhibit licensing, G1 synchronization, siRNA knockdown Genome biology Medium 40624716
2025 CDK activity controls TRESLIN and MTBP abundance and chromatin recruitment to promote dormant origin activation. WEE1 inhibition (increased CDK activity) blocks PCNA-dependent degradation of TRESLIN and enhances chromatin loading of both TRESLIN and MTBP, leading to elevated helicase recruitment. This effect depends on both TRESLIN and MTBP, and a conserved TRESLIN sequence mediates CDK-sensitive degradation. WEE1 inhibition, CDK inhibition, PCNA degradation assays, chromatin fractionation, siRNA knockdown, DNA synthesis assays bioRxivpreprint Medium bio_10.1101_2025.06.10.657920
2025 MTBP allosterically activates Cdk8/19-CycC kinase activity in vitro by repositioning the T-loop of the kinase independently of T-loop phosphorylation, acting as a targeting and activation factor distinct from Med12. MTBP targets Cdk8/19-CycC to Med12-independent cellular roles (including replication origin firing), while Med12 targets it to the Mediator complex for transcription control. Both MTBP and Med12 are mutually exclusive allosteric activators of Cdk8/19-CycC. In vitro kinase assays, structural analysis, mutagenesis, protein interaction studies bioRxivpreprint Medium bio_10.1101_2025.06.16.659917

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. The Journal of biological chemistry 90 10906133
2005 Regulation of p53 and MDM2 activity by MTBP. Molecular and cellular biology 62 15632057
2012 MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4. Oncogene 47 22370640
2017 MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication. Molecular biology of the cell 39 28877985
2014 Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Cancer research 38 24786788
2014 MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival. Molecular cancer research : MCR 34 24866769
2007 Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene 27 17906694
2021 The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-initiation complex formation. Open biology 23 34699733
2020 Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication. Cell reports 22 32966791
2011 MTBP plays a crucial role in mitotic progression and chromosome segregation. Cell death and differentiation 22 21274008
2011 Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck. Cancer 22 21692053
2021 Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis. International journal of molecular sciences 20 33809929
2015 MTBP inhibits migration and metastasis of hepatocellular carcinoma. Clinical & experimental metastasis 20 25759210
2022 The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition. Molecular cell 19 36049481
2019 MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas. Theranostics 19 31534534
2018 MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma. Oncotarget 19 29765550
2022 MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging. Biology 14 35741402
2021 MTBP phosphorylation controls DNA replication origin firing. Scientific reports 14 33608586
2018 MTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial-mesenchymal transition in lung cancer cells. OncoTargets and therapy 14 30349307
2015 MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin. Digestive diseases and sciences 14 26280083
2012 The enhancement of stability of p53 in MTBP induced p53-MDM2 regulatory network. Bio Systems 12 23059707
2022 MTBP enhances the activation of transcription factor ETS-1 and promotes the proliferation of hepatocellular carcinoma cells. Frontiers in oncology 9 36106099
2016 Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. Aging 9 27803394
2021 MTBP promoted the proliferation, migration and invasion of colon cancer cells by activating the expression of ZEB2. Animal cells and systems 8 34262658
2017 Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with Autoinflammatory Disease (SPAID). BMC genomics 8 28472921
2006 Telomere and TRF2/MTBP localization in respect to satellite DNA during the cell cycle of mouse cell line L929. Rejuvenation research 8 16859480
2003 Telomere-binding TRF2/MTBP localization during mouse spermatogenesis and cell cycle of the mouse cells L929. Journal of anti-aging medicine 8 14614800
2003 A telomere-binding protein (TRF2/MTBP) from mouse nuclear matrix with motives of an intermediate filament-type rod domain. Journal of anti-aging medicine 8 14987434
2025 Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns. Genome biology 6 40624716
2025 Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication. Nature communications 5 41331242
2023 C9orf142 transcriptionally activates MTBP to drive progression and resistance to CDK4/6 inhibitor in triple-negative breast cancer. Clinical and translational medicine 5 38009308
2022 The Role of MTBP as a Replication Origin Firing Factor. Biology 5 35741348
2024 Cell Cycle-Dependent TICRR/TRESLIN and MTBP Chromatin Binding Mechanisms and Patterns. bioRxiv : the preprint server for biology 4 38370757
2019 [MTBP regulates migration and invasion of prostate cancer cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 4 30692060
2024 Circular RNA Circ_0000119 promotes gastric cancer progression via circ_0000119/miR-502-5p/MTBP axis. Gene 3 38378131
2018 Hyper expression of MTBP may be an adverse signal for the survival of some malignant tumors: A data-based analysis and clinical observation. Medicine 3 30170409
2007 Dynamics of satellite binding protein CENP-B and telomere binding protein TRF2/MTBP in the nuclei of mouse spermatogenic line. Cell biology international 2 17353134
2025 Unveiling the enigmatic role of MTBP in pan-cancer: A bioinformatics perspective. Pathology, research and practice 1 40680629
2025 The study of MDM2 binding protein (MTBP) in response to apoptosis in Litopenaeus vannamei under ammonia and nitrite nitrogen stress. Fish & shellfish immunology 1 41046925
2023 Characterization of an Mtbp Hypomorphic Allele in a Diethylnitrosamine-Induced Liver Carcinogenesis Model. Cancers 0 37760565

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