Affinage

MTA3

Metastasis-associated protein MTA3 · UniProt Q9BTC8

Length
594 aa
Mass
67.5 kDa
Annotated
2026-06-10
46 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MTA3 is a context-dependent subunit of the Mi-2/NuRD transcriptional corepressor complex that confers cell-type-specific gene repression across epithelial, immune, germ, and developmental programs (PMID:12705869, PMID:15454082). In breast epithelial cells MTA3 acts downstream of estrogen receptor to repress the transcriptional repressor Snail, sustaining E-cadherin expression and restraining invasive growth (PMID:12705869); this same MTA3–Snail axis is recapitulated in trophoblast cells, where MTA3 directly occupies and represses the Snail and CGB5 promoters (PMID:23510993). In germinal center B cells MTA3 is recruited by the transcription factor BCL-6 to repress plasma cell differentiation genes, an interaction sensitive to BCL-6 acetylation (PMID:15454082), and in T follicular helper cells the BCL-6 middle domain recruits MTA3 to silence Prdm1/Blimp1, with acetylation-mimetic BCL-6 blocking recruitment and derepressing the target (PMID:26460037). MTA3 partners with NuRD subunits and chromatin regulators including CHD4, HDAC1, HDAC2, and HDAC11, the last binding MTA3 through its N-terminal region to form a NuRD(MTA3) complex that represses TGFB1 (PMID:22075476, PMID:28959722, PMID:37401867, PMID:41547814), and it assembles with sequence-specific factors such as GATA3 and a SIX3/LSD1 module to repress targets including SOX2OT and EMT-associated genes (PMID:29463994, PMID:31810000). Beyond transcriptional repression, MTA3 interacts with the cohesin subunit RAD21 and supports G2/M progression in granulosa cells (PMID:22075476), drives steroidogenesis in Leydig cells under transcriptional control by NR4A1 (PMID:27673553, PMID:35239504), and is required for primitive hematopoiesis upstream of scl/lmo2 in zebrafish (PMID:19864643). MTA3 and its paralog MTA1 mutually repress one another's transcription and are genetically redundant, as compound Mta3-BAH-deletion/Mta1-null mice are synthetically lethal (PMID:39154024, PMID:40758820).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2003 High

    Established MTA3 as a functional NuRD subunit linking estrogen signaling to epithelial integrity, answering whether MTA-family proteins have distinct, regulated roles in gene repression.

    Evidence Co-IP, RNAi, reporter assays and epistasis in breast epithelial cells

    PMID:12705869

    Open questions at the time
    • Direct biochemical mechanism of Snail promoter recruitment not resolved
    • Did not address non-epithelial contexts
  2. 2004 High

    Showed MTA3 is a cell-type-specific NuRD subunit recruited by a sequence-specific transcription factor (BCL-6), explaining how NuRD achieves lineage-restricted repression.

    Evidence Reciprocal Co-IP, RNAi, expression profiling in germinal center B cells

    PMID:15454082

    Open questions at the time
    • Structural basis of acetylation-sensitive BCL-6/MTA3 interaction not defined
    • In vivo requirement not tested at this stage
  3. 2009 High

    Placed Mta3-NuRD in a developmental hierarchy, demonstrating it is required upstream of scl/lmo2 for primitive hematopoiesis.

    Evidence Morpholino knockdown with scl/lmo2 rescue and HDAC inhibitor phenocopy in zebrafish

    PMID:19864643

    Open questions at the time
    • Direct target genes of Mta3 in hematopoietic precursors not identified
    • Mammalian conservation of this hierarchy untested
  4. 2011 Medium

    Connected MTA3 regulation to ERβ signaling and dietary phytoestrogens, extending estrogen control of the MTA3/Snail/E-cadherin axis to choriocarcinoma invasion.

    Evidence ERβ siRNA epistasis with invasion assays and molecular readouts in JAR cells

    PMID:22866146

    Open questions at the time
    • Whether ERβ regulates MTA3 directly or indirectly unresolved
    • Single cell-line context
  5. 2012 High

    Defined the in vivo recruitment determinant, showing the BCL-6 middle domain recruits MTA3 to repress Blimp1 and that BCL-6 acetylation gates this in T follicular helper differentiation.

    Evidence BCL-6 K379Q knock-in, ChIP, Prdm1-ablation rescue in vivo

    PMID:26460037

    Open questions at the time
    • Full target repertoire beyond Prdm1 not mapped
    • Does not address other NuRD subunit contributions
  6. 2012 High

    Revealed a non-canonical role beyond transcriptional repression, linking MTA3 to cohesin and cell-cycle control.

    Evidence In vivo Co-IP with CHD4/HDAC1/RAD21 plus RNAi with rescue and cell-cycle analysis in granulosa cells

    PMID:22075476

    Open questions at the time
    • Mechanism by which MTA3 promotes G2/M progression unresolved
    • Whether the RAD21 interaction is transcriptional or structural unclear
  7. 2013 High

    Provided direct evidence of promoter occupancy, demonstrating MTA3 binds and represses Snail and CGB5 promoters in trophoblasts.

    Evidence ChIP, siRNA, promoter-luciferase, qRT-PCR

    PMID:23510993

    Open questions at the time
    • Recruiting transcription factor at these promoters not identified
    • NuRD subunit composition at these loci not defined
  8. 2016 Medium

    Established a tissue-specific role for MTA3 in testicular steroidogenesis distinct from its repressive functions.

    Evidence shRNA knockdown and overexpression rescue with hormone-stimulated progesterone assays in MA-10 Leydig cells

    PMID:27673553

    Open questions at the time
    • Transcriptional targets driving steroidogenesis unknown
    • Whether NuRD complex is involved here untested
  9. 2018 Medium

    Expanded the MTA3 interactome and reinforced its EMT-suppressive role in trophoblast invasion, and identified a SIX3/LSD1 NuRD(MTA3) module suppressing breast cancer EMT.

    Evidence Co-IP/mass spectrometry (71 partners), invasion assays, and AP-MS with ChIP-on-chip

    PMID:28959722 PMID:29463994

    Open questions at the time
    • Functional contribution of most identified partners untested
    • Direct vs indirect nature of many interactions unresolved
  10. 2018 Medium

    Identified an upstream regulatory axis, showing miR-146a-5p represses MTA3 via its 3'UTR to impair steroidogenesis under BPA exposure.

    Evidence 3'UTR luciferase reporter, miR overexpression, hMTA3 rescue in Leydig cells

    PMID:29746863

    Open questions at the time
    • Physiological relevance of miR-146a-5p targeting in vivo limited
    • Downstream steroidogenic targets not defined
  11. 2019 Medium

    Demonstrated MTA3 partners with GATA3 to repress an lncRNA (SOX2OT), linking MTA3 to control of cancer stemness via the SOX2OT/SOX2 axis.

    Evidence Co-IP, ChIP, overexpression/knockdown and in vivo tumor models in ESCC

    PMID:31810000

    Open questions at the time
    • Whether GATA3 directly recruits MTA3 to the SOX2OT locus structurally unresolved
    • Single tumor type
  12. 2022 Medium

    Extended MTA3 function to therapy resistance and immune evasion, showing it represses CRIP2 to activate NF-κB and gemcitabine resistance, and acts downstream of SPHK1 to regulate PD-L1.

    Evidence CRISPR activation screen, ChIP, PDX models, and immunocompetent tumor models with T-cell co-culture

    PMID:35981571 PMID:36050478

    Open questions at the time
    • Direct mechanism of PD-L1 transcriptional regulation by MTA3 not detailed
    • Context dependence of pro- vs anti-tumor MTA3 roles unresolved
  13. 2022 Medium

    Defined NR4A1 as a transcriptional activator of MTA3 in Leydig cells, integrating MTA3 into oxidative-stress-sensitive steroidogenic control.

    Evidence NR4A1 transactivation assays, overexpression rescue, in vivo lentiviral replenishment in diabetic mice

    PMID:35239504

    Open questions at the time
    • Direct NR4A1 binding site on MTA3 promoter not mapped
    • Mechanistic link between MTA3 and steroidogenic enzymes unresolved
  14. 2023 Medium

    Showed MTA3 physically interacts with and downregulates HDAC2, suppressing NSCLC migration via reduced c-Myc and cyclin D1.

    Evidence Co-IP, CRISPR-edited cell lines, wound-healing/Transwell assays, qRT-PCR

    PMID:37401867

    Open questions at the time
    • Mechanism by which MTA3 lowers HDAC2 levels unclear
    • Reconciliation of HDAC2 partnership vs repression untested
  15. 2024 Medium

    Revealed a mutual transcriptional repression loop between MTA3 and MTA1 that estrogen disrupts, framing MTA3 as an antagonist of MTA1-driven breast cancer stemness/EMT.

    Evidence ChIP, luciferase reporter, ubiquitination assay, in vitro/in vivo functional assays

    PMID:39154024

    Open questions at the time
    • Quantitative balance setpoint of the MTA1/MTA3 loop not defined
    • Role of TRIM21-mediated MTA1 stability in the loop incompletely resolved
  16. 2025 Medium

    Extended MTA3 to fibroblast biology, placing it upstream of p38 MAPK/E2F1 in suppressing fibroblast-to-myofibroblast transition, and defined an HDAC11-MTA3 complex repressing TGFB1.

    Evidence Overexpression, E2F1 RNAi, SB203580 inhibition and MI model; GST pull-down/Co-IP with transcriptomics in HCC

    PMID:40615041 PMID:41547814

    Open questions at the time
    • Direct transcriptional targets bridging MTA3 to p38/E2F1 not identified
    • Whether HDAC11-MTA3 acts at the TGFB1 promoter directly via ChIP not shown in narrative
  17. 2025 Medium

    Provided in vivo genetic proof of functional redundancy within NuRD, showing Mta3 BAH-domain loss is tolerated alone but synthetically lethal with Mta1 null.

    Evidence CRISPR deletion, synthetic lethality crosses, conditional B-cell deletion in mice

    PMID:40758820

    Open questions at the time
    • Molecular function of the MTA3 BAH domain not defined
    • Shared vs distinct target genes underlying redundancy not mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MTA3 selects between repressive (Snail, Blimp1, CRIP2, TGFB1) and context-specific activating/structural roles (steroidogenesis, cohesin/cell cycle, PD-L1) within a single NuRD framework remains unresolved.
  • No unifying biochemical model distinguishing MTA3 target selection across tissues
  • Structural determinants of partner-specific recruitment undefined
  • Genome-wide direct target maps across cell types incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 5 GO:0060090 molecular adaptor activity 4
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 1
Pathway
R-HSA-74160 Gene expression (Transcription) 6 R-HSA-168256 Immune System 4 R-HSA-4839726 Chromatin organization 4 R-HSA-1266738 Developmental Biology 3
Partners
BCL6CHD4GATA3HDAC1HDAC11HDAC2MTA1RAD21
Complex memberships
Mi-2/NuRD complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 MTA3 is an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor complex in breast epithelial cells; its absence leads to aberrant expression of the transcriptional repressor Snail, resulting in loss of E-cadherin expression and invasive growth. Co-immunoprecipitation, RNAi knockdown, reporter assays, Western blot; genetic epistasis placing MTA3 downstream of estrogen receptor and upstream of Snail/E-cadherin Cell High 12705869
2004 MTA3 is a cell-type-specific subunit of the Mi-2/NuRD corepressor complex that physically interacts with the transcription factor BCL-6 to mediate BCL-6-dependent repression of plasma cell differentiation genes in germinal center B cells; this interaction is sensitive to BCL-6 acetylation status, and MTA3 depletion by RNAi impairs BCL-6-dependent repression. Co-immunoprecipitation, RNAi knockdown, gene expression profiling, ectopic BCL-6 expression in plasma cell lines Cell High 15454082
2001 Mouse Mta3 (60 kDa) localizes to both nucleus and cytoplasm when GFP-tagged and expressed in keratinocytes, in contrast to Mta1 which is exclusively nuclear; Mta1 nuclear localization requires at least one NLS and one SH3 binding site, and Mta1 SH3 ligands interact with Grb2 and Fyn. GFP-fusion protein transfection and fluorescence microscopy, deletion constructs, co-immunoprecipitation with Grb2 and Fyn Gene Medium 11483358
2009 Knockdown of mta3 by antisense morpholinos in zebrafish abolishes primitive hematopoietic lineages; overexpression of scl or scl/lmo2 rescues mta3 knockdown hematopoietic defects, placing Mta3-NuRD upstream of scl and lmo2 in the primitive hematopoiesis hierarchy; overexpression of mta3, MBD3, or HDAC1 enhances scl and lmo2 expression. Antisense morpholino knockdown in zebrafish, genetic epistasis by rescue with scl/lmo2 overexpression, HDAC inhibitor phenocopy experiments Blood High 19864643
2012 MTA3 interacts with NuRD proteins CHD4 and HDAC1 and the cohesin subunit RAD21 in mouse ovarian granulosa cells; MTA3 depletion slows granulosa cell proliferation (rescued by re-expression of exogenous MTA3), reduces cyclin B1 and B2 expression, and causes accumulation of cells in G2/M phase with reduced histone H3-Ser10 phosphorylation, indicating a role in G2/M progression. Co-immunoprecipitation in vivo, RNAi knockdown with rescue, cell cycle analysis, Western blot for cyclins and phospho-histone H3 Biology of reproduction High 22075476
2013 In trophoblast cells, MTA3 directly occupies the proximal promoter regions of CGB5 (hCG β-subunit) and Snail as shown by ChIP; siRNA-mediated knockdown of MTA3 increases CGB5 and Snail promoter activity and their mRNA levels, establishing MTA3 as a direct transcriptional repressor of both genes. Chromatin immunoprecipitation (ChIP), siRNA knockdown, promoter-luciferase reporter assays, qRT-PCR Biochemical and biophysical research communications High 23510993
2015 BCL-6 middle domain (RDII) recruits MTA3 to repress Prdm1 (Blimp1) and other target genes in T follicular helper (Tfh) cells; mimicked acetylation of BCL-6 K379Q prevents MTA3 recruitment and derepresses Prdm1, reducing Tfh differentiation in vivo; loss of BCL-6/MTA3 function could be partially rescued by abrogating Prdm1 expression. In vivo T cell differentiation with BCL-6 K379Q knock-in, ChIP, genetic rescue by Prdm1 ablation, flow cytometry Proceedings of the National Academy of Sciences of the United States of America High 26460037
2016 MTA3 is expressed predominantly in interstitial Leydig cells of rodent testis; shRNA-mediated ablation of Mta3 inhibits HCG/db-cAMP-stimulated progesterone secretion in MA-10 Leydig cells, while overexpression of MTA3 rescues Mta3-deficiency-impaired progesterone production, establishing a functional role for MTA3 in testicular steroidogenesis. shRNA knockdown, MTA3 overexpression, hormone stimulation assays, Western blot, qRT-PCR Endocrinology Medium 27673553
2017 MTA3 knockdown in HTR8/SVneo extravillous trophoblast cells increases invasive capacity and upregulates MMP2, MMP9, and Snail; Co-IP/Western blot confirmed MTA3 interaction with HDAC1 (NuRD subunit); Co-IP/mass spectrometry identified 71 MTA3-interacting proteins including NuRD subunits, heterochromatin proteins, epigenetic modifiers, and transcription factors. shRNA lentiviral knockdown, transwell invasion assay, Co-immunoprecipitation-Western blot, Co-IP-mass spectrometry AIMS medical science Medium 28959722
2018 SIX3 physically associates with LSD1 and the NuRD(MTA3) complex; affinity purification-mass spectrometry identified this complex, which binds chromatin at WNT1 and FOXC2 target genes to suppress carcinogenesis and EMT in breast cancer cells. Affinity purification-mass spectrometry, ChIP-on-chip genome-wide analysis, functional invasion and proliferation assays Theranostics Medium 29463994
2018 BPA-induced miR-146a-5p represses Mta3 expression by directly targeting its 3′UTR in murine Leydig cells, exacerbating BPA's inhibitory effects on testicular steroidogenesis; ectopic expression of hMTA3 rescues miR-146a-5p-elicited steroidogenic inhibition. 3′UTR luciferase reporter assay, miR-146a-5p overexpression, hMTA3 rescue overexpression, Western blot, hormone assays Biochemical and biophysical research communications Medium 29746863
2019 MTA3 forms a repressive complex with GATA3, which directly downregulates the lncRNA SOX2OT, subsequently suppressing the SOX2OT/SOX2 axis to repress cancer cell stemness and metastasis in esophageal squamous cell carcinoma in vitro and in vivo. Co-immunoprecipitation (MTA3-GATA3 complex), ChIP, gene overexpression and knockdown, in vivo tumor models iScience Medium 31810000
2022 MTA3, as a component of the Mi-2/NuRD complex, transcriptionally represses CRIP2 (a repressor of NF-κB/p65), thereby activating NF-κB signaling and inducing gemcitabine resistance in pancreatic ductal adenocarcinoma; GEM treatment increases MTA3 expression via STAT3 signaling. CRISPR/Cas9 activation library screen, ChIP, in vitro and in vivo functional assays, Western blot, patient-derived xenograft model Cancer letters Medium 35981571
2022 MTA3 functions downstream of SPHK1 to transcriptionally regulate PD-L1 expression in tumor cells, mediating immune evasion; MTA3 overexpression promotes PD-L1 upregulation and immune evasion, which is rescued by anti-PD-1 treatment. Functional knockdown/overexpression studies, immunocompetent mouse tumor models, T-cell co-culture assays, mechanistic analysis of SPHK1→MTA3→PD-L1 pathway Cellular & molecular immunology Medium 36050478
2023 MTA3 physically interacts with HDAC2 (Co-IP validated); MTA3 overexpression decreases HDAC2 expression levels and rescues HDAC2-induced migration and invasion of NSCLC cells by reducing c-Myc and cyclin D1 expression. Co-immunoprecipitation, Western blot, CRISPR-edited cell lines (rs13213007 A/A genotype), wound-healing and Transwell assays, qRT-PCR Molecular carcinogenesis Medium 37401867
2022 NR4A1 transcriptionally activates MTA3 in mouse Leydig cells; oxidative stress induced by T2DM suppresses NR4A1-mediated MTA3 transactivation, reducing MTA3 expression and impairing steroidogenesis; in vivo lentiviral MTA3 replenishment restores steroidogenesis and improves fertility in diabetic mice. NR4A1 transactivation assays, NR4A1 overexpression rescuing MTA3 expression, in vivo lentiviral gene transfer, testosterone/fertility measurements Reproduction (Cambridge, England) Medium 35239504
2024 MTA3 represses MTA1 transcription (ChIP demonstrated MTA3 occupancy at MTA1 promoter), while MTA1 represses MTA3 transcription, forming a feedback loop; TRIM21 regulates MTA1 protein stability (ubiquitination assay); MTA3 inhibits MTA1-driven breast cancer stemness and EMT, and estrogen disrupts the MTA1/MTA3 balance. ChIP, luciferase reporter assay, immunoprecipitation, ubiquitination assay, in vitro and in vivo functional assays Cell death & disease Medium 39154024
2025 MTA3 regulates fibroblast-to-myofibroblast transition via the p38 MAPK–E2F1 signaling pathway: MTA3 overexpression reduces α-SMA and Collagen I expression in cardiac fibroblasts, and E2F1 RNAi phenocopies this suppression; inhibition of p38 MAPK phosphorylation with SB203580 also reduces myofibroblast markers, indicating MTA3 operates through p-p38/E2F1. MTA3 overexpression plasmid transfection, RNAi of E2F1, SB203580 pharmacologic p38 inhibition, immunofluorescence, Western blot, qRT-PCR, myocardial infarction mouse model The Journal of biological chemistry Medium 40615041
2025 Deletion of the BAH domain of Mta3 (Mta3ΔBAH allele) in mice yields viable, fertile animals with modest B lymphocyte activation defects; compound homozygosity for Mta3ΔBAH and Mta1 null alleles is synthetically lethal, revealing a genetic redundancy between Mta1 and Mta3; conditional deletion in B cells shows selection against loss in post-germinal center stages. CRISPR/Cas9 deletion of coding exons 1–2, genetic crosses for synthetic lethality, conditional B cell-specific deletion, B cell activation assays, antibody production assays, behavioral testing G3 (Bethesda, Md.) Medium 40758820
2026 HDAC11 directly binds to MTA3 via its N-terminal region (demonstrated by GST pull-down and immunoprecipitation), forming a NuRD(MTA3) complex that transcriptionally represses TGFB1 to inhibit HCC metastasis. Mass spectrometry, immunoprecipitation, GST pull-down, transcriptomic analysis, siRNA knockdown, in vitro and in vivo assays Clinical epigenetics Medium 41547814
2011 Genistein inhibits JAR choriocarcinoma cell invasion through an ERβ-dependent mechanism involving MTA3: genistein decreases MTA3 mRNA, increases Snail mRNA, and upregulates E-cadherin protein; ERβ siRNA knockdown abolishes all these effects, placing ERβ upstream of MTA3/Snail/E-cadherin in this pathway. ERβ siRNA knockdown, Matrigel invasion assay, qRT-PCR, Western blot, epistasis by receptor KD Oncology letters Medium 22866146
2013 MTA3 overexpression in HTR8/SVneo trophoblast cells upregulates HIF1α protein levels and increases HIF1α target gene expression (HRE-luciferase activity) under hypoxic conditions, indicating MTA3 positively regulates HIF1α activity in trophoblasts. MTA3 overexpression, HRE-luciferase reporter assay, Western blot for HIF1α, hypoxia treatment Medical journal of obstetrics and gynecology Low 25705708
2021 Knockdown of MTA3 (but not MTA1) in human embryonic stem cells induces mesendoderm differentiation; DYRK inhibitor ID8 counteracts MTA3-knockdown-induced differentiation through DYRK4 activity, placing DYRK4 downstream of MTA3 in ESC pluripotency maintenance. siRNA knockdown, high-throughput transcriptomic sequencing, qRT-PCR, small molecule library screening with ID8, DYRK4 functional assay Biochemical and biophysical research communications Low 33744762

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 425 12705869
2004 MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 279 15454082
2013 MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 47 24293376
2009 Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. Blood 43 19864643
2018 Bisphenol A-elicited miR-146a-5p impairs murine testicular steroidogenesis through negative regulation of Mta3 signaling. Biochemical and biophysical research communications 42 29746863
2009 The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells. Histochemistry and cell biology 42 19363681
2001 Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. Gene 39 11483358
2018 The Homeotic Protein SIX3 Suppresses Carcinogenesis and Metastasis through Recruiting the LSD1/NuRD(MTA3) Complex. Theranostics 34 29463994
2015 Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3. Proceedings of the National Academy of Sciences of the United States of America 34 26460037
2019 Catalpol inhibits cell proliferation, invasion and migration through regulating miR-22-3p/MTA3 signalling in hepatocellular carcinoma. Experimental and molecular pathology 28 31145886
2010 The metastasis-associated gene MTA3 is downregulated in advanced endometrioid adenocarcinomas. Histology and histopathology 28 20865667
2019 Long non-coding RNA HCG11 suppresses the growth of glioma by cooperating with the miR-4425/MTA3 axis. The journal of gene medicine 26 30706982
2007 The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. The Journal of pathology 25 17573669
2013 Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer. PloS one 24 23840517
2022 Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis. Cellular & molecular immunology 23 36050478
2017 MiR-367 regulates cell proliferation and metastasis by targeting metastasis-associated protein 3 (MTA3) in clear-cell renal cell carcinoma. Oncotarget 23 28968973
2019 MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience 22 31810000
2022 Genome-wide CRISPR screen identifies MTA3 as an inducer of gemcitabine resistance in pancreatic ductal adenocarcinoma. Cancer letters 21 35981571
2016 Regulated and Functional Expression of the Corepressor MTA3 in Rodent Testis. Endocrinology 21 27673553
2013 MTA3 regulates CGB5 and Snail genes in trophoblast. Biochemical and biophysical research communications 21 23510993
2012 Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells. Biology of reproduction 19 22075476
2019 Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis. Human molecular genetics 18 30281099
2019 MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma. Frontiers in oncology 15 31552166
2016 The Many Faces of MTA3 Protein in Normal Development and Cancers. Current protein & peptide science 15 27033852
2014 Function and regulation of MTA1 and MTA3 in malignancies of the female reproductive system. Cancer metastasis reviews 15 25319202
2017 MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 14 28351306
2011 Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway. Oncology letters 14 22866146
2019 High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition. Molecular medicine reports 13 30816482
2013 MTA1 and MTA3 Regulate HIF1a Expression in Hypoxia-Treated Human Trophoblast Cell Line HTR8/Svneo. Medical journal of obstetrics and gynecology 13 25705708
2022 lncRNA PCAT1 might coordinate ZNF217 to promote CRC adhesion and invasion through regulating MTA2/MTA3/Snai1/E-cadherin signaling. Cellular and molecular biology (Noisy-le-Grand, France) 11 35809308
2015 MTA3 regulates differentiation of human cytotrophoblast stem cells. Placenta 10 26198267
2023 The HDAC2-MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c-Myc and cyclin D1. Molecular carcinogenesis 9 37401867
2021 Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells. Biochemical and biophysical research communications 9 33744762
2024 The feedback loop between MTA1 and MTA3/TRIM21 modulates stemness of breast cancer in response to estrogen. Cell death & disease 8 39154024
2022 The effect of progesterone administration on the expression of metastasis tumor antigens (MTA1 and MTA3) in placentas of normal and dexamethasone-treated rats. Molecular biology reports 6 35037193
2022 T2DM-elicited oxidative stress represses MTA3 expression in mouse Leydig cells. Reproduction (Cambridge, England) 5 35239504
2015 [Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells]. Zhongguo fei ai za zhi = Chinese journal of lung cancer 4 26483332
2025 MiR-138 reprograms dental pulp stem cells into GABAergic neurons via the GATAD2B/MTA3/WNTs axis for stroke treatment. Biomaterials 3 40803231
2025 The metastasis-associated protein MTA3 promotes cardiac repair by inhibiting the fibroblast to myofibroblast transition during fibrosis. The Journal of biological chemistry 2 40615041
2017 MTA3 Regulates Extravillous Trophoblast Invasion Through NuRD Complex. AIMS medical science 2 28959722
2025 A novel mutant allele of Mta3 in the mouse: genetic analysis of roles in immunity and androgen biology. G3 (Bethesda, Md.) 1 40758820
2024 Discovery of Jaspamycin from marine-derived natural product based on MTA3 to inhibit hepatocellular carcinoma progression. Scientific reports 1 39455636
2022 [Corrigendum] High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition. Molecular medicine reports 1 36004471
2017 Immunohistochemical expression of MTA1 and MTA3 in placental tissue of normal and preeclamptic pregnancies. Clinical and experimental obstetrics & gynecology 1 29949275
2026 HDAC11 interacts with the NuRD (MTA3) complex to transcriptionally suppress TGFβ1 expression and inhibit hepatocellular carcinoma metastasis. Clinical epigenetics 0 41547814
2026 Mechanisms of MTA3 in cancer and related diseases and its clinical applications. Frontiers in oncology 0 41584603

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