Affinage

MSN

Moesin · UniProt P26038

Length
577 aa
Mass
67.8 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 3/3 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MSN (moesin) is an ERM-family membrane-cytoskeleton linker whose FERM domain directly binds the cytoplasmic tail of the receptor CD44, with PIP2 binding to the FERM domain allosterically stimulating CD44 engagement through a neighboring receptor-tail pocket (PMID:37866628). Hemizygous loss-of-function mutations in the MSN FERM domain (R171W missense, R533X nonsense) cause X-linked primary immunodeficiency marked by lymphopenia, poor T-cell proliferation, and altered migration and adhesion, with the proliferation defect rescued by wild-type MSN re-expression (PMID:27405666). In oncogenic contexts MSN serves both as a structural fusion partner and as a signaling node: it fuses to ALK to generate a membrane-localized 125 kDa MSN-ALK tyrosine kinase in anaplastic large cell lymphoma (PMID:11310834, PMID:15297972), and as full-length protein it drives tumor progression through multiple pathways—PKC-dependent phosphorylation and NONO-assisted nuclear translocation to activate CREB (PMID:32128390), stabilization of c-Met protein (PMID:30026327), activation of PI3K/mTOR to drive proneural-to-mesenchymal transition and chemoradiotherapy resistance in glioma stem cells (PMID:39921260), and promotion of colorectal cancer via the β-catenin–RUNX2 axis (PMID:37446127).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1994 High

    Establishing the genomic organization and chromosomal location of MSN provided the structural foundation by demarcating its conserved protein domains and X-linked locus.

    Evidence Somatic cell hybrid analysis, FISH, primer extension, and genomic sequencing

    PMID:8188263

    Open questions at the time
    • Does not establish protein function
    • Promoter element activity (SP1/AP1) not functionally tested in vivo
  2. 2001 High

    Identification of MSN as an ALK fusion partner showed that MSN's membrane-association capacity can be coopted to mislocalize and activate a tyrosine kinase, defining a structural-oncogenic role.

    Evidence Molecular cloning, IHC, genomic breakpoint sequencing, and Western blot in anaplastic large cell lymphoma

    PMID:11310834 PMID:15297972

    Open questions at the time
    • Downstream signaling of MSN-ALK not mechanistically dissected here
    • Contribution of the MSN portion to kinase activity vs. localization not separated
  3. 2016 High

    Loss-of-function genetics established MSN as causally required for normal T-cell proliferation, migration, and adhesion, defining its physiological role in immunity.

    Evidence Exome/targeted sequencing, flow cytometry, proliferation assays, and wild-type MSN rescue across 7 patients from 5 families

    PMID:27405666

    Open questions at the time
    • Molecular link between FERM mutations and migration/adhesion defects not resolved
    • Whether defects are cell-intrinsic to T cells only is not fully defined
  4. 2018 Medium

    Demonstrating MSN-mediated c-Met protein stabilization placed MSN within a regulatory circuit controlling stemness and EMT in breast cancer.

    Evidence XIST silencing/knockout, Western blot for c-Met, and xenograft/GEMM models

    PMID:30026327

    Open questions at the time
    • Mechanism by which MSN stabilizes c-Met not defined
    • Single lab; direct MSN–c-Met physical interaction not shown
  5. 2020 Medium

    Discovery of phosphorylated MSN nuclear translocation via NONO and PKC redefined MSN as a signaling effector that activates CREB beyond its membrane role.

    Evidence Co-IP, nuclear fractionation, phosphorylation assays, shRNA, and in vitro/in vivo breast cancer models

    PMID:32128390

    Open questions at the time
    • Reciprocal validation of MSN-NONO interaction limited
    • Phosphosite(s) driving nuclear import not mapped
  6. 2023 High

    Structural and biophysical dissection of the FERM domain revealed an allosteric mechanism by which PIP2 binding stimulates CD44 tail engagement, mechanistically defining MSN's membrane-receptor linkage.

    Evidence Structural studies, site-directed mutagenesis, phage display, and HTS for small-molecule inhibitors

    PMID:37866628

    Open questions at the time
    • Cellular consequences of disrupting the allosteric site not tested
    • Connection to disease mutations (R171W) not directly examined
  7. 2023 Medium

    Epistasis experiments placed MSN upstream of a β-catenin–RUNX2 axis, defining a transcriptional output of MSN signaling in colorectal cancer.

    Evidence shRNA, overexpression, RNA-seq, and pharmacological β-catenin/GSK3β rescue in colorectal cancer cells

    PMID:37446127

    Open questions at the time
    • Direct molecular link between MSN and β-catenin stabilization not defined
    • Single lab
  8. 2025 Medium

    Linking MSN to PI3K/mTOR-driven proneural-to-mesenchymal transition connected MSN to therapy resistance and provided a druggable axis in glioma stem cells.

    Evidence MSN KD/OE, Western blot for PI3K/mTOR components, chemoradiotherapy resistance assays, and GNE-317 inhibitor treatment in vitro and in vivo

    PMID:39921260

    Open questions at the time
    • How MSN activates PI3K/mTOR mechanistically not resolved
    • GNE-317 specificity for MSN not fully established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MSN's defined membrane-cytoskeleton linker activity (FERM/PIP2/CD44) mechanistically connects to its diverse downstream oncogenic signaling outputs (c-Met, CREB, β-catenin, PI3K/mTOR) and to the T-cell defects of immunodeficiency remains unresolved.
  • No unified mechanism linking membrane scaffolding to nuclear/signaling roles
  • Substrate or direct binding events for most oncogenic axes undefined
  • Structure-function link between disease mutations and specific molecular activities not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 1 GO:0008289 lipid binding 1 GO:0060090 molecular adaptor activity 1
Localization
GO:0005886 plasma membrane 2 GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 1 R-HSA-168256 Immune System 1
Partners
ALKCD44NONO

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 MSN (moesin) was identified as a fusion partner for ALK in anaplastic large cell lymphoma. The hybrid MSN-ALK protein (125 kDa) contains an active tyrosine kinase domain, and the unique membrane-restricted ALK staining pattern reflects association of moesin with cell membrane proteins. The ALK breakpoint occurred within exonic sequence coding for the juxtamembrane portion of ALK, and genomic breakpoint analysis confirmed in-frame fusion of MSN intron 10 to a shorter juxtamembrane exon of ALK. Molecular cloning, immunohistochemistry, genomic breakpoint sequencing, Western blot Laboratory investigation; a journal of technical methods and pathology High 11310834 15297972
2016 Hemizygous loss-of-function mutations in MSN (including R171W missense in the FERM domain and R533X nonsense) cause X-linked primary immunodeficiency characterized by profound lymphopenia, hypogammaglobulinemia, poor T-cell proliferation, reduced naive T cells, elevated CD57+ senescent CD8+ T cells, poor chemokine receptor expression, increased adhesion molecule expression, and altered migration and adhesion. T-cell proliferation defects were rescued by re-expression of wild-type MSN, establishing direct causality. Genetic analysis (exome/targeted sequencing), flow cytometry, T-cell proliferation assays, wild-type MSN rescue experiment, migration/adhesion assays The Journal of allergy and clinical immunology High 27405666
2020 MSN physically interacts with the nuclear protein NONO. Phosphorylated MSN undergoes NONO-assisted nuclear localization via protein kinase C (PKC). Once in the nucleus, PKC-bound MSN activates CREB signaling through PKC-mediated phosphorylation of CREB. This pathway promotes breast cancer cell proliferation and invasion in vitro and tumor growth in vivo. Co-immunoprecipitation, nuclear fractionation/localization assays, phosphorylation assays, shRNA knockdown, in vitro proliferation/invasion assays, in vivo xenograft Science advances Medium 32128390
2018 Loss of XIST lncRNA activates c-Met signaling via MSN-mediated protein stabilization, promoting stemness and epithelial-mesenchymal transition in breast cancer cells. MSN was shown to stabilize c-Met protein, and this MSN-c-Met axis contributes to brain metastasis. XIST silencing/knockout, Western blot for c-Met protein levels, xenograft and GEMM models, gene expression analysis Cancer research Medium 30026327
1994 The MSN gene encoding moesin was mapped to Xq11.2-q12. The gene spans >30 kb with 12 exons; exon/intron junctions demarcate individual highly conserved protein domains. Primer extension analysis identified two major transcription start sites. The 5'-flanking region is GC-rich, lacks a TATA box, and contains SP1 and AP1 binding sites. Southern blot, Western blot, somatic cell hybrid analysis, fluorescence in situ hybridization (FISH), primer extension, genomic sequencing Genomics High 8188263
2023 The FERM domain of MSN directly interacts with the cytoplasmic tail of CD44. Structural, mutational, and phage-display studies revealed an allosteric site near the PIP2 binding pocket of the FERM domain that influences CD44 binding. PIP2 binding to the FERM domain stimulates CD44 binding through an allosteric mechanism, creating a neighboring pocket for receptor tail accommodation. Small molecule inhibitors of the MSN-CD44 interaction were identified by high-throughput screening. Structural studies (crystal/biophysical), site-directed mutagenesis, phage display, high-throughput chemical library screening, binding assays The Journal of biological chemistry High 37866628
2025 MSN activates the PI3K/mTOR signaling pathway in glioma stem cells (GSCs), driving proneural-to-mesenchymal transition (PMT). This enhances repair of DNA damage caused by radiotherapy and temozolomide, increasing chemoradiotherapy resistance. GNE-317, a small molecule inhibitor, specifically inhibits MSN and suppresses downstream PI3K/mTOR activation, reversing PMT and sensitizing GSCs to chemoradiotherapy. MSN knockdown/overexpression, Western blot for PI3K/mTOR pathway components, in vitro and in vivo chemoradiotherapy resistance assays, small molecule inhibitor treatment Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 39921260
2020 MSN silencing significantly decreased invasiveness of bladder urothelial carcinoma cell lines in a 3D invasion assay, establishing a functional role for MSN in cancer cell invasion. shRNA knockdown, 3D in vitro invasion assay, proteomics Cancers Low 32326232
2023 MSN promotes colorectal cancer progression via the β-catenin–RUNX2 signaling axis. MSN silencing decreased cytoplasmic and nuclear β-catenin levels; pharmacological inhibition of β-catenin in MSN-overexpressing cells reduced RUNX2 expression; activating β-catenin by inhibiting GSK3β rescued RUNX2 downregulation in MSN-knockdown cells, confirming MSN regulates RUNX2 via β-catenin. shRNA knockdown, plasmid overexpression, Western blot, RNA sequencing, pharmacological β-catenin/GSK3β modulation, cell proliferation/migration assays International journal of molecular sciences Medium 37446127
2022 MSN stabilizes PD-L1 protein in hepatocellular carcinoma cells. miR-133a-3p targets MSN (validated by dual-luciferase reporter assay), and MSN inhibits the antitumor effect of APS by maintaining PD-L1 stability. Western blot for PD-L1 protein levels, dual-luciferase reporter assay for miR-133a-3p/MSN interaction, flow cytometry, shRNA knockdown Pharmaceutical biology Low 36086826
2022 Hemizygous nonsense mutation W217X in MSN results in significantly decreased MSN mRNA expression and causes an autoimmune phenotype (antiphospholipid syndrome, Hashimoto's thyroiditis, leg ulcers, juvenile tooth loss) with immune dysregulation including low naive T cells and elevated activated T-helper cells, extending the known phenotypic spectrum of MSN loss-of-function. Whole exome sequencing, flow cytometry immunophenotyping, qRT-PCR for MSN mRNA expression Frontiers in immunology Low 36119109

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition. Advanced materials (Deerfield Beach, Fla.) 316 24142549
2018 Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer research 262 30026327
2014 MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression. Advanced materials (Deerfield Beach, Fla.) 185 25159109
2011 Drugs of abuse screening in urine as part of a metabolite-based LC-MSn screening concept. Analytical and bioanalytical chemistry 118 21533799
2002 Targeted proteomics of low-level proteins in human plasma by LC/MSn: using human growth hormone as a model system. Journal of proteome research 106 12645918
2001 Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. Laboratory investigation; a journal of technical methods and pathology 105 11310834
2001 A combined linear ion trap time-of-flight system with improved performance and MS(n) capabilities. Rapid communications in mass spectrometry : RCM 81 11565095
2018 Nucleus Accumbens Microcircuit Underlying D2-MSN-Driven Increase in Motivation. eNeuro 75 29780881
2007 A fragmentation study of isoflavones in negative electrospray ionization by MSn ion trap mass spectrometry and triple quadrupole mass spectrometry. Rapid communications in mass spectrometry : RCM 73 17294515
2021 A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state. Cell research 63 34848869
2016 X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene. The Journal of allergy and clinical immunology 62 27405666
2005 New and automated MSn approaches for top-down identification of modified proteins. Journal of the American Society for Mass Spectrometry 59 16253516
2015 Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling. Cell discovery 54 27462435
2014 Nutritional composition and antioxidant capacity in edible flowers: characterisation of phenolic compounds by HPLC-DAD-ESI/MSn. International journal of molecular sciences 52 25561232
2014 Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses. Molecular & cellular proteomics : MCP 51 25048706
2007 Pronase-immobilized enzyme reactor: an approach for automation in glycoprotein analysis by LC/LC-ESI/MSn. Analytical chemistry 48 17194161
2022 Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell reports 45 35172164
2019 Rod-shape MSN@MoS2 Nanoplatform for FL/MSOT/CT Imaging-Guided Photothermal and Photodynamic Therapy. Theranostics 45 31281527
1989 A monoclonal antibody (MSN-1) against a newly established uterine endometrial cancer cell line (SNG-II) and its application to immunohistochemistry and flow cytometry. American journal of obstetrics and gynecology 44 2478021
2003 Characterization of protein variants and post-translational modifications: ESI-MSn analyses of intact proteins eluted from polyacrylamide gels. Molecular & cellular proteomics : MCP 43 12832455
2016 Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 42 26860538
2020 Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. Science advances 39 32128390
2016 pH responsive cylindrical MSN for oral delivery of insulin-design, fabrication and evaluation. Drug delivery 38 27540687
2008 Studies on the stability of diester-diterpenoid alkaloids from the genus Aconitum L. by high performance liquid chromatography combined with electrospray ionisation tandem mass spectrometry (HPLC/ESI/MSn). Phytochemical analysis : PCA 38 17853383
2020 A MSN-based tumor-targeted nanoplatform to interfere with lactate metabolism to induce tumor cell acidosis for tumor suppression and anti-metastasis. Nanoscale 36 31971210
2021 Smart MSN-Drug-Delivery System for Tumor Cell Targeting and Tumor Microenvironment Release. ACS applied materials & interfaces 34 34463488
2013 Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn. Analytical and bioanalytical chemistry 32 23774830
2021 Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages. Cellular & molecular immunology 31 34480147
2006 Automated quantification tool for high-throughput proteomics using stable isotope labeling and LC-MSn. Analytical chemistry 31 16906720
2022 Astragalus polysaccharide (APS) attenuated PD-L1-mediated immunosuppression via the miR-133a-3p/MSN axis in HCC. Pharmaceutical biology 30 36086826
2011 Identification and characterization of stressed degradation products of metoprolol using LC/Q-TOF-ESI-MS/MS and MS(n) experiments. Biomedical chromatography : BMC 30 21989963
2021 Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals. Molecular psychiatry 29 34642457
2016 Isomeric complexity of glycosylation documented by MSn. Analytical and bioanalytical chemistry 29 27826629
2002 Multiple ion isolation applications in FT-ICR MS: exact-mass MSn internal calibration and purification/interrogation of protein-drug complexes. Analytical chemistry 29 12175179
2017 An MSN-PEG-IP drug delivery system and IL13Rα2 as targeted therapy for glioma. Nanoscale 28 28443896
2015 Characterization of Anthocyanins in Perilla frutescens var. acuta Extract by Advanced UPLC-ESI-IT-TOF-MSn Method and Their Anticancer Bioactivity. Molecules (Basel, Switzerland) 27 25996217
2009 Identification and characterization of degradation products of irbesartan using LC-MS/TOF, MS(n), on-line H/D exchange and LC-NMR. Journal of pharmaceutical and biomedical analysis 27 20018473
2021 Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity. Molecular psychiatry 26 34349226
2013 Studies on the metabolism and toxicological detection of glaucine, an isoquinoline alkaloid from Glaucium flavum (Papaveraceae), in rat urine using GC-MS, LC-MS(n) and LC-high-resolution MS(n). Journal of mass spectrometry : JMS 26 23303745
2008 Study of forced decomposition behavior of lamivudine using LC, LC-MS/TOF and MS(n). Journal of pharmaceutical and biomedical analysis 26 19022602
2004 Heterogeneity of genomic breakpoints in MSN-ALK translocations in anaplastic large cell lymphoma. Human pathology 25 15297972
1999 An essential saccharide binding domain for the mAb 2C7 established for Neisseria gonorrhoeae LOS by ES-MS and MSn. Glycobiology 24 9949193
2018 Rapid Characterization and Identification of Non-Diterpenoid Constituents in Tinospora sinensis by HPLC-LTQ-Orbitrap MSn. Molecules (Basel, Switzerland) 23 29382158
2017 Screening active compounds from Corydalis yanhusuo by combining high expression VEGF receptor HEK293 cell membrane chromatography with HPLC - ESI - IT - TOF - MSn method. Journal of pharmaceutical and biomedical analysis 23 28081499
2023 A Novel pH-Responsive Iron Oxide Core-Shell Magnetic Mesoporous Silica Nanoparticle (M-MSN) System Encapsulating Doxorubicin (DOX) and Glucose Oxidase (Gox) for Pancreatic Cancer Treatment. International journal of nanomedicine 22 38054080
2022 Effects of Biofilm Nano-Composite Drugs OMVs-MSN-5-FU on Cervical Lymph Node Metastases From Oral Squamous Cell Carcinoma. Frontiers in oncology 21 35515126
2017 An enhanced chemotherapeutic effect facilitated by sonication of MSN. Dalton transactions (Cambridge, England : 2003) 21 28849842
2013 Macrophage biospecific extraction and HPLC-ESI-MSn analysis for screening immunological active components in Smilacis Glabrae Rhizoma. Journal of pharmaceutical and biomedical analysis 21 23384550
2021 Genotoxicity and Immunotoxicity of Titanium Dioxide-Embedded Mesoporous Silica Nanoparticles (TiO2@MSN) in Primary Peripheral Human Blood Mononuclear Cells (PBMC). Nanomaterials (Basel, Switzerland) 18 33494245
2020 Moesin (MSN) as a Novel Proteome-Based Diagnostic Marker for Early Detection of Invasive Bladder Urothelial Carcinoma in Liquid-Based Cytology. Cancers 18 32326232
2010 Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 18 20558285
2010 HPLC-DAD-MSn to investigate the photodegradation pathway of nicosulfuron in aqueous solution. Analytical and bioanalytical chemistry 18 21136044
2009 Optimization and validation of a liquid chromatography tandem mass spectrometry (LC/MSn) method for analysis of corticosteroids in bovine liver: evaluation of Keyhole Limpet beta-glucuronidase/sulfatase enzyme extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 18 19211313
2007 New insights in the formation of deoxynucleoside adducts with the heterocyclic aromatic amines PhIP and IQ by means of ion trap MSn and accurate mass measurement of fragment ions. Journal of the American Society for Mass Spectrometry 17 17936011
2014 Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient. Frontiers in cellular neuroscience 16 25520619
2011 Stress degradation studies on lornoxicam using LC, LC-MS/TOF and LC-MSn. Journal of pharmaceutical and biomedical analysis 16 21757313
2000 C-terminal peptide sequencing using acetylated peptides with MSn in a quadrupole ion trap. The Analyst 16 10892020
2014 Metabolism Study of Veratramine Associated with Neurotoxicity by Using HPLC-MSn. Journal of chromatographic science 15 25547283
2010 Identification and characterization of a photolytic degradation product of telmisartan using LC-MS/TOF, LC-MSn, LC-NMR and on-line H/D exchange mass studies. Journal of pharmaceutical and biomedical analysis 15 20554147
2008 Web conferencing systems: Skype and MSN in telepathology. Diagnostic pathology 15 18673501
2024 Synergistic pH-responsive MUC-1 aptamer-conjugated Ag/MSN Janus nanoparticles for targeted chemotherapy, photothermal therapy, and gene therapy in breast cancer. Biomaterials advances 14 39454415
2021 MSN, MWCNT and ZnO nanoparticle-induced CHO-K1 cell polarisation is linked to cytoskeleton ablation. Journal of nanobiotechnology 14 33579304
2008 Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations. Journal of pharmaceutical and biomedical analysis 14 18378108
2007 Bidirectional ion transfer between quadrupole arrays: MSn ion/ion reaction experiments on a quadrupole/time-of-flight tandem mass spectrometer. Analytical chemistry 14 17914865
1994 Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN). Genomics 14 8188263
2022 Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50. Frontiers in immunology 13 36119109
2013 LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: a comprehensive approach during drug development. Analytical and bioanalytical chemistry 13 23386001
2023 Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. The Journal of biological chemistry 12 37866628
2019 Ablation of striatal somatostatin interneurons affects MSN morphology and electrophysiological properties, and increases cocaine-induced hyperlocomotion in mice. The European journal of neuroscience 12 31549447
2011 A nano-chip-LC/MSn based strategy for characterization of modified nucleosides using reduced porous graphitic carbon as a stationary phase. Journal of the American Society for Mass Spectrometry 12 21953107
2024 Enhanced theranostic efficacy of epirubicin-loaded SPION@MSN through co-delivery of an anti-miR-21-expressing plasmid and ZIF-8 hybridization to target colon adenocarcinoma. Nanoscale 11 38446130
2022 Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity-prone female rats. Obesity (Silver Spring, Md.) 11 36575127
2020 Investigation of the emission spectra and cytotoxicity of TiO2 and Ti-MSN/PpIX nanoparticles to induce photodynamic effects using X-ray. Photodiagnosis and photodynamic therapy 11 32311544
2014 Screening for potential -α -Glucosidase inhibitors in Coptis chinensis franch extract using ultrafiltration LC-ESI-MSn. Pakistan journal of pharmaceutical sciences 11 25410064
2008 A fragmentation study of two compounds related to 4'-demethylepipodophyllotoxin in negative ion electrospray ionization by MSn ion-trap time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 11 18183636
2004 Nucleotide variation at Msn and Alas2, two genes flanking the centromere of the X chromosome in humans. Genetics 11 15166166
2002 Isomer separation of hyperbranched polyesteramides with gas-phase H/D exchange and a novel MS(n) approach: DoDIP. Journal of mass spectrometry : JMS 10 12203673
1998 Calcium ionophore-induced degradation of neurofilament and cell death in MSN neuroblastoma cells. Neurochemical research 10 9482252
2023 Identification of Moesin (MSN) as a Potential Therapeutic Target for Colorectal Cancer via the β-Catenin-RUNX2 Axis. International journal of molecular sciences 9 37446127
2022 Transcription factor Sp9 is a negative regulator of D1-type MSN development. Cell death discovery 9 35773249
2022 The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity. Frontiers in cell and developmental biology 9 36081908
2018 MSN-on-a-Chip: Cell-Based Screenings Made Possible on a Small-Molecule Microarray of Native Natural Products. Chembiochem : a European journal of chemical biology 9 29465822
2018 Aspartic acid functionalized PEGylated MSN@GO hybrid as an effective and sustainable nano-system for in-vitro drug delivery. Advances in medical sciences 9 29486375
2012 Structural Identification of O-Linked Oligosaccharides Using Exoglycosidases and MSn Together with UniCarb-DB Fragment Spectra Comparison. Metabolites 9 24957756
2004 Sodium butyrate induces apoptosis in MSN neuroblastoma cells in a calcium independent pathway. Neurochemical research 9 15662847
1990 MSN-1 antibody in the evaluation of female genital tract adenocarcinomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 9 2294065
2021 Preparation of ZIF@ADH/NAD-MSN/LDH Core Shell Nanocomposites for the Enhancement of Coenzyme Catalyzed Double Enzyme Cascade. Nanomaterials (Basel, Switzerland) 8 34578486
2014 Enhancing MS(n) mass spectrometry strategy for carbohydrate analysis: A b2 ion spectral library. Journal of proteomics 8 25175058
2013 Use of experimental design methodology for the development of new magnetic siRNA nanovectors (MSN). International journal of pharmaceutics 8 23726903
2013 Profiling and characterization of sialylated N-glycans by 2D-HPLC (HIAX/PGC) with online orbitrap MS/MS and offline MSn. Journal of pharmaceutical sciences 8 24302562
2023 Isoquercitrin from Apocynum venetum L. Exerts Antiaging Effects on Yeasts via Stress Resistance Improvement and Mitophagy Induction through the Sch9/Rim15/Msn Signaling Pathway. Antioxidants (Basel, Switzerland) 7 38001792
2022 MSN@IL-4 Sustainingly Mediates Macrophagocyte M2 Polarization and Relieves Osteoblast Damage via NF-κB Pathway-Associated Apoptosis. BioMed research international 7 36225981
2022 Gentirigeoside B from Gentiana rigescens Franch Prolongs Yeast Lifespan via Inhibition of TORC1/Sch9/Rim15/Msn Signaling Pathway and Modification of Oxidative Stress and Autophagy. Antioxidants (Basel, Switzerland) 7 36552582
2015 Structural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis. Xenobiotica; the fate of foreign compounds in biological systems 7 26259024
2014 Characterization of stress degradation products of fosinopril by using LC-MS/TOF, MS(n) and on-line H/D exchange. Journal of pharmaceutical and biomedical analysis 7 24518132
2011 LC, LC-MS/TOF and MS(n) studies for the identification and characterization of degradation products of nelfinavir mesylate. Journal of pharmaceutical and biomedical analysis 7 21392920
2006 Selective ion tracing and MSn analysis of peptide digests from FSBA-treated kinases for the analysis of protein ATP-binding sites. Journal of proteome research 7 16889425
2005 HPLC-MSn to investigate the oxidative destruction pathway of aromatic sulfonate wastes. Journal of environmental quality 7 16275734
2025 GNE-317 Reverses MSN-Mediated Proneural-to-Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 39921260
2023 Two cases of pediatric primary immunodeficiency caused by a familial moesin(MSN)gene mutation. Clinical immunology (Orlando, Fla.) 6 38052292

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