Affinage

MSMB

Beta-microseminoprotein · UniProt P08118

Length
114 aa
Mass
12.9 kDa
Annotated
2026-04-28
100 papers in source corpus 12 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MSMB encodes PSP94 (beta-microseminoprotein), a prostate epithelial secretory protein that functions as a tumor suppressor by inhibiting anchorage-independent growth and suppressing MMP-9-dependent invasion through laminin receptor/ERK signaling and RhoA/MT1-MMP-mediated CD44 shedding (PMID:21085629, PMID:16283486, PMID:16550001). PSP94 is synthesized in prostatic epithelial cells under androgen and steroid hormone regulation, and its expression is epigenetically silenced in androgen-refractory prostate cancer through EZH2-mediated H3K27 trimethylation and promoter CpG hypermethylation (PMID:3182395, PMID:11108266, PMID:17237810). The crystal structure reveals a two-domain Greek-key fold in which terminal beta-strands form an antiparallel homodimer interface that also mediates binding to CRISP-3, with pH-dependent dissociation (PMID:20184897). Transcriptional output is modulated by the prostate cancer risk SNP rs10993994, where the C allele preferentially binds CREB to drive higher expression, and the locus also generates MSMB-NCOA4 fusion transcripts whose expression is governed by the same promoter variants (PMID:19383797, PMID:22661295).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1987 Medium

    Despite sequence similarity to 'beta-inhibin', PSP94 was shown to lack FSH-inhibiting activity, ruling out an endocrine role and redirecting investigation toward its prostatic function.

    Evidence In vitro FSH secretion bioassay using rat pituitary cell cultures with positive controls

    PMID:3109514

    Open questions at the time
    • No alternative biological activity was identified at this stage
    • Only one endocrine endpoint tested
  2. 1988 Medium

    Demonstration that PSP94 mRNA and protein co-localize in prostatic epithelial cells established the prostate as the primary site of synthesis, framing MSMB as a prostate-specific secretory gene.

    Evidence Immunohistochemistry and in situ hybridization in human prostate tissue

    PMID:3182395

    Open questions at the time
    • Mechanism of secretion not addressed
    • Expression in non-prostatic tissues not systematically surveyed
  3. 1995 Medium

    Discovery of an alternative splice isoform (PSP57) lacking exon III, with a novel basic C-terminus and nuclear localization in tumor cells, revealed MSMB generates functionally distinct isoforms with potentially different subcellular roles.

    Evidence RT-PCR, cloning/sequencing, and nuclear fractionation in urogenital tissues and tumor cell lines

    PMID:7566962

    Open questions at the time
    • Function of PSP57 isoform not determined
    • Nuclear role remains uncharacterized
    • Only demonstrated in cell lines, not validated in vivo
  4. 2000 Medium

    In vivo hormonal manipulation established that PSP94 expression is androgen-dependent and also responsive to glucocorticoids and progestins, defining MSMB as a steroid-regulated gene.

    Evidence Castration/testosterone replacement in rats with RT-PCR, in situ hybridization, and Western blotting

    PMID:11108266

    Open questions at the time
    • Direct hormone-responsive elements in the MSMB promoter not mapped
    • Relevance to human prostate hormone regulation assumed but not directly tested
  5. 2005 Medium

    A PSP94-derived peptide (PCK3145) was shown to inhibit MMP-9 secretion and trigger MT1-MMP/RhoA-dependent CD44 shedding, providing the first mechanistic link between PSP94 and suppression of cell invasion.

    Evidence Zymography, RT-PCR, flow cytometry, immunoblotting, and adhesion assays in HT-1080 cells

    PMID:16283486

    Open questions at the time
    • Activity demonstrated with a synthetic peptide fragment, not full-length PSP94
    • Relevance to prostate cancer cells not shown
    • Mechanism of RhoA activation unknown
  6. 2006 Medium

    Identification of the 37-kDa laminin receptor precursor as the cell-surface receptor for PSP94-derived peptide, with downstream ERK activation and HuR-dependent MMP-9 mRNA destabilization, defined the signaling pathway mediating anti-invasive activity.

    Evidence Far-Western binding, 37LRP overexpression, MEK inhibitor experiments in HT-1080 cells

    PMID:16550001

    Open questions at the time
    • Binding of full-length PSP94 to 37LRP not confirmed
    • Pathway not validated in prostate epithelial cells
    • Single far-Western approach for receptor identification
  7. 2007 High

    EZH2-mediated H3K27 trimethylation, combined with H3K9 hypoacetylation and CpG island hypermethylation, was identified as the mechanism of MSMB silencing in androgen-refractory prostate cancer, establishing epigenetic regulation as a key control layer.

    Evidence ChIP, EZH2 RNAi knockdown and overexpression, bisulfite sequencing in prostate cancer cell lines

    PMID:17237810

    Open questions at the time
    • Whether epigenetic silencing is causally linked to disease progression not established
    • Relative contribution of H3K27me3 versus DNA methylation not dissected
  8. 2009 High

    The prostate cancer risk SNP rs10993994 was shown to directly modulate MSMB transcription via differential CREB binding, connecting a GWAS-identified genetic variant to a specific transcription factor mechanism.

    Evidence Luciferase reporter assays and EMSA in prostate cancer cell lines stratified by genotype

    PMID:19383797

    Open questions at the time
    • ChIP confirmation of CREB occupancy at the endogenous locus not shown
    • Additional transcription factors at this site not excluded
  9. 2010 High

    Structural determination of PSP94 revealed a homodimer formed through antiparallel beta-strand edge interactions and identified this same interface as the binding site for CRISP family proteins, unifying oligomerization and partner recognition.

    Evidence X-ray crystallography at 2.3 Å resolution with biochemical pH-dependent dissociation assays

    PMID:20184897

    Open questions at the time
    • No co-crystal structure of PSP94-CRISP-3 complex
    • Functional consequence of dimer versus monomer form unknown
    • IgG binding via same edge is inferred, not structurally proven
  10. 2010 Medium

    Functional evidence that MSMB suppression promotes anchorage-independent growth established a direct tumor-suppressive role, while PSP94 and CRISP-3 were shown to independently inhibit prostate cancer cell growth.

    Evidence Loss-of-function growth assays in prostate epithelial cells; clonogenic survival with ectopic PSP94/CRISP-3 expression

    PMID:20676114 PMID:21085629

    Open questions at the time
    • Downstream pathway by which loss of PSP94 permits anchorage independence not identified
    • In vivo tumor suppression not demonstrated
    • PSP94-CRISP-3 functional interplay not mechanistically resolved
  11. 2012 Medium

    Discovery of MSMB-NCOA4 fusion transcripts regulated by the same promoter variants linked to prostate cancer risk expanded the functional output of the MSMB locus beyond PSP94 alone.

    Evidence RT-PCR/sequencing of fusion transcripts, luciferase promoter deletion mapping

    PMID:22661295

    Open questions at the time
    • Biological function of the MSMB-NCOA4 fusion protein not tested
    • Protein-level expression and stability in vivo not confirmed
    • Whether fusion contributes to prostate cancer risk independently of PSP94 unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The mechanism by which full-length secreted PSP94 exerts tumor-suppressive activity in vivo, the identity of its physiological receptor on prostate epithelial cells, and the functional significance of the PSP94-CRISP-3 interaction remain unresolved.
  • No in vivo knockout or transgenic tumor model published
  • Receptor for intact PSP94 on prostate cells not identified
  • Structural basis of CRISP-3 binding not determined at atomic resolution

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4
Localization
GO:0005576 extracellular region 3
Partners
CREB1CRISP3EZH2NCOA4RPSA

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 The MSMB gene (encoding PSP94) is epigenetically silenced in androgen-refractory prostate cancer cells by EZH2-mediated trimethylation of histone H3 on Lys27 (H3K27me3), as well as by histone H3K9 hypoacetylation and CpG island hypermethylation in the MSMB promoter. RNAi knockdown of EZH2 reduced H3K27 trimethylation and increased MSMB expression, while EZH2 overexpression decreased MSMB expression. Chromatin immunoprecipitation confirmed EZH2 association with the MSMB gene. ChIP, RNAi knockdown, overexpression, bisulfite sequencing Oncogene High 17237810
2009 The rs10993994 SNP, located 57 bp upstream of the first exon of MSMB, regulates MSMB promoter activity; the C allele preferentially binds the CREB transcription factor (shown by EMSA), and cell lines with CC or CT genotypes exhibit higher MSMB expression than TT genotype lines. Luciferase reporter assays confirmed the T variant reduces transcriptional activity. Luciferase reporter assay, EMSA, genotype-expression analysis in tumor cell lines Proceedings of the National Academy of Sciences of the United States of America High 19383797
2010 Suppression of MSMB expression promotes anchorage-independent growth of prostate epithelial cells, establishing a tumor-suppressive role for MSMB/PSP94 in prostate-specific cellular context. The rs10993994 risk allele is associated with decreased expression of MSMB isoforms in both histologically normal and malignant prostate tissue. Loss-of-function (MSMB suppression) with anchorage-independent growth assay; genotype-expression correlation in prostate tissue cohort PLoS genetics Medium 21085629
2010 Crystal structure of human PSP94 (MSMB gene product) at 2.3 Å resolution reveals that the N- and C-termini are held in close proximity by a hydrogen bond between the first and last beta-strands, forming a straight edge. Two monomers associate antiparallel via this edge to form a homodimer. Dimers dissociate to monomers at acidic pH. The same edge is proposed to mediate binding to cysteine-rich secretory proteins (e.g., CRISP-3) and IgG. X-ray crystallography, biochemical dissociation assays Journal of molecular biology High 20184897
1987 Beta-microseminoprotein (beta-MSP/PSP94), despite near-identical sequence to so-called 'beta-inhibin', does not inhibit FSH secretion from rat pituitary cells in culture, demonstrating that PSP94 lacks inhibin activity. In vitro FSH secretion bioassay using rat pituitary cell culture Biology of reproduction Medium 3109514
1988 PSP94 (MSMB gene product) is synthesized in the epithelial cells of the prostate gland, as shown by co-localization of immunoreactive PSP94 protein and its mRNA in prostatic epithelial cells by immunohistochemistry and in situ hybridization. Immunohistochemistry, in situ hybridization histochemistry Journal of andrology Medium 3182395
1995 Alternative splicing of the MSMB/PSP94 mRNA produces a shorter isoform (PSP57) in which exon III is deleted, encoding a 57-amino acid protein with a novel basic C-terminus. PSP57 mRNA is detected in urogenital tissues and tumor cell lines but not breast or lung, and in prostate tumor cell lines it is aberrantly spliced and localizes to the nuclear fraction. RT-PCR, Southern blotting, cloning and sequencing, nuclear fractionation Oncogene Medium 7566962
2012 Promoter variants at the MSMB locus associated with prostate cancer regulate expression of full-length MSMB-NCOA4 fusion transcripts. The predominant fusion arises from splicing of MSMB 5'UTR and exons 1-2 to NCOA4 exons 2-10, producing a stable fusion protein containing essential NCOA4 domains. A core MSMB promoter element between -27 and -236 and a negative regulatory element immediately upstream of the start codon were mapped by deletion/luciferase assays. RT-PCR/sequencing of fusion transcripts, luciferase reporter deletion assays, computational analysis Human genetics Medium 22661295
2005 PCK3145 (a synthetic peptide from PSP94/MSMB amino acids 31-45) inhibits MMP-9 secretion and triggers CD44 shedding from the cell surface of HT-1080 fibrosarcoma cells. This involves RhoA signaling and MT1-MMP-mediated CD44 ectodomain shedding, and inhibits cell adhesion to hyaluronic acid, laminin-1, and type-I collagen. Gelatin zymography, RT-PCR, flow cytometry, immunoblotting, cell adhesion assay Clinical & experimental metastasis Medium 16283486
2006 The PCK3145 PSP94-derived peptide binds the HT-1080 cell surface through the 37-kDa laminin receptor precursor (37LRP), as demonstrated by far-Western ligand binding studies; overexpression of 37LRP increases PCK3145 binding. This cell surface binding triggers ERK phosphorylation and leads to downregulation of HuR protein (an mRNA stabilizer), resulting in MMP-9 mRNA destabilization and reduced MMP-9 secretion. Far-Western ligand binding, overexpression, flow cytometry, immunoblotting, gelatin zymography, MEK inhibitor experiment Anti-cancer drugs Medium 16550001
2010 MSMB/PSP94 and its binding protein CRISP-3 individually inhibit prostate cancer cell growth in a cell-line-specific manner. PSP94 inhibits growth of CRISP-3-positive cell lines, while CRISP-3-mediated growth inhibition is independent of PSP94 presence, as determined by clonogenic survival assays with ectopic expression of each protein. Clonogenic survival assay, stable transfection, Western blot, immunofluorescence Asian journal of andrology Medium 20676114
2000 PSP94 (MSMB gene product) mRNA and protein expression in rat lateral prostate is under androgen regulation: castration abolishes expression while testosterone replacement restores it. Expression is also induced by glucocorticoid (dexamethasone) and progestin (medroxyprogesterone acetate), but not by zinc, distinguishing it from probasin regulation. In situ hybridization, semiquantitative RT-PCR, Western blotting, hormone manipulation in castrated rats Endocrinology Medium 11108266

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. The EMBO journal 280 8062829
1991 Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics 194 1726950
2003 The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. Developmental cell 168 12919677
2013 MSP-RON signalling in cancer: pathogenesis and therapeutic potential. Nature reviews. Cancer 162 23792360
2006 Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism. Addiction biology 146 16961763
1994 Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Protein science : a publication of the Protein Society 142 7756992
2003 Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. The American journal of tropical medicine and hygiene 140 12641400
2011 Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet. Journal of physiology and biochemistry 115 21465273
2009 MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans. Development (Cambridge, England) 114 19502484
2000 Asynchronous activation of 10 muscle-specific protein (MSP) genes during zebrafish somitogenesis. Developmental dynamics : an official publication of the American Association of Anatomists 114 11002340
2006 Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Current biology : CB 99 16824915
2000 Plasmodium vivax synonymous substitution frequencies, evolution and population structure deduced from diversity in AMA 1 and MSP 1 genes. Molecular and biochemical parasitology 95 10802318
1993 The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. The Journal of cell biology 92 8314841
2003 Sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-1 (MSP-1) of Plasmodium falciparum. Gene 90 12568716
2007 The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2. Oncogene 89 17237810
1995 Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development. Developmental genetics 83 7554499
2009 Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proceedings of the National Academy of Sciences of the United States of America 81 19383797
2005 Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine. Vaccine 81 16356603
2009 Somatic cAMP signaling regulates MSP-dependent oocyte growth and meiotic maturation in C. elegans. Development (Cambridge, England) 77 19502483
1997 Conservation of structural motifs and antigenic diversity in the Plasmodium falciparum merozoite surface protein-3 (MSP-3). Molecular and biochemical parasitology 76 9497029
2010 Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis. PLoS genetics 68 21085629
1997 Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp. Journal of bacteriology 64 9023187
2009 Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM. BMC cancer 62 20025721
1993 Sequence diversity and organization of the msp gene family encoding gp63 of Leishmania chagasi. Molecular and biochemical parasitology 59 8139613
2005 The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Developmental biology 55 16337624
1996 A Drosophila dystrophin-related protein, MSP-300, is required for embryonic muscle morphogenesis. Mechanisms of development 54 9025063
1992 Structure and macromolecular assembly of two isoforms of the major sperm protein (MSP) from the amoeboid sperm of the nematode, Ascaris suum. Journal of cell science 51 1527183
2006 Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53. Oncogene 50 16170349
2002 Plasmodium vivax MSP-1 peptides have high specific binding activity to human reticulocytes. Vaccine 48 11818151
2008 Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans. Current biology : CB 47 18472420
2002 Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model. Gene therapy 45 12424611
2001 Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin. British journal of pharmacology 45 11704649
1999 Kinases involved in MSP/RON signaling. Journal of leukocyte biology 43 10080538
2018 MSP-4, an Antimicrobial Peptide, Induces Apoptosis via Activation of Extrinsic Fas/FasL- and Intrinsic Mitochondria-Mediated Pathways in One Osteosarcoma Cell Line. Marine drugs 42 29301308
2010 Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis. Biochemistry 42 20377183
2008 Relevance of MSP assay for the detection of MGMT promoter hypermethylation in glioblastomas. International journal of oncology 42 18695875
2004 A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8. The Journal of biological chemistry 40 14976193
1995 Complementary deoxyribonucleic acid cloning and characterization of mSP-10: the mouse homologue of human acrosomal protein SP-10. Biology of reproduction 39 8547483
2005 A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis. Clinical & experimental metastasis 37 16283486
2008 On the roles of the Drosophila KASH domain proteins Msp-300 and Klarsicht. Fly 35 18820482
1987 Beta-microseminoprotein (beta-MSP) is not an inhibin. Biology of reproduction 35 3109514
2000 PSP94 expression after androgen deprivation therapy: a comparative study with prostate specific antigen in benign prostate and prostate cancer. The Journal of urology 34 11025776
2018 Genetic diversity of the msp-1, msp-2, and glurp genes of Plasmodium falciparum isolates in Northwest Ethiopia. Malaria journal 33 30359280
2014 MSMB variation and prostate cancer risk: clues towards a possible fungal etiology. The Prostate 33 24464504
2005 MSP domain proteins. Trends in parasitology 32 15837611
2000 Clonality analysis by methylation-specific PCR for the human androgen-receptor gene (HUMARA-MSP). Leukemia 32 10637497
2020 MSP-RON Pathway: Potential Regulator of Inflammation and Innate Immunity. Frontiers in immunology 31 33117355
2020 circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts. BMC pregnancy and childbirth 30 33109096
2010 Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence. International journal of oncology 30 20428780
1991 Rapid evolution of prostatic protein PSP94 suggested by sequence divergence between rhesus monkey and human cDNAs. Genomics 30 2037304
2013 Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing. Scientific reports 29 24071855
2014 Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats. Psychopharmacology 28 25260340
2007 The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi. Molecular and biochemical parasitology 28 18067978
2017 Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness. The Prostate 27 29250809
1995 Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue. Oncogene 27 7566962
2006 Sperm motility and MSP. WormBook : the online review of C. elegans biology 26 18050481
2001 Anti-apoptotic action of macrophage stimulating protein (MSP). Apoptosis : an international journal on programmed cell death 26 11388667
1993 Basic proteinases from Bothrops moojeni (caissaca) venom--II. Isolation of the metalloproteinase MPB. Comparison of the proteolytic activity on natural substrates by MPB, MSP 1 and MSP 2. Toxicon : official journal of the International Society on Toxinology 26 8503136
2010 Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3. Prostate cancer and prostatic diseases 25 20680031
2004 Shortening and modifying the 1513 MSP-1 peptide's alpha-helical region induces protection against malaria. Biochemical and biophysical research communications 25 14766224
2003 Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 25 12797974
1988 Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate. Journal of andrology 25 3182395
1993 Decreased expression of prostatic secretory protein PSP94 in prostate cancer. Cancer letters 24 7506990
2011 Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations. PloS one 23 22069488
2000 Prostatic secretory protein (PSP94) expression in human female reproductive tissues, breast and in endometrial cancer cell lines. The Journal of endocrinology 23 10810306
2019 New Insights into Multistep-Phosphorelay (MSP)/ Two-Component System (TCS) Regulation: Are Plants and Bacteria that Different? Plants (Basel, Switzerland) 22 31835810
2014 Genetic diversity of the msp-1, msp-2, and glurp genes of Plasmodium falciparum isolates along the Thai-Myanmar borders. Asian Pacific journal of tropical biomedicine 22 25183327
2010 MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling. Developmental biology 22 20380830
2014 Production and preclinical evaluation of Plasmodium falciparum MSP-119 and MSP-311 chimeric protein, PfMSP-Fu24. Clinical and vaccine immunology : CVI 21 24789797
2012 Role of major sperm protein (MSP) in the protrusion and retraction of Ascaris sperm. International review of cell and molecular biology 21 22608562
2005 Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. Journal of molecular biology 21 15755452
2005 Variation in the relationship between anti-MSP-1(19) antibody response and age in children infected with Plasmodium falciparum during the dry and rainy seasons. Acta tropica 21 16055071
1994 Plasmodium vivax: dimorphic DNA sequences from the MSP-1 gene code for regions that are immunogenic in natural infections. Experimental parasitology 21 8056078
2004 Multiple products of the Leishmania chagasi major surface protease (MSP or GP63) gene family. Molecular and biochemical parasitology 20 15110459
2004 A novel transmembrane MSP-containing protein that plays a role in right ventricle development. Genomics 20 15533722
2002 An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity. Nature biotechnology 20 11981563
2017 Qingchang Wenzhong Decoction Attenuates DSS-Induced Colitis in Rats by Reducing Inflammation and Improving Intestinal Barrier Function via Upregulating the MSP/RON Signalling Pathway. Evidence-based complementary and alternative medicine : eCAM 19 29234405
2008 Polymorphism in the Plasmodium vivax msp 3: gene in field samples from Tierralta, Colombia. Memorias do Instituto Oswaldo Cruz 19 18797765
1997 Evolution of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Ciba Foundation symposium 19 9524762
2023 Multisystem proteinopathies (MSPs) and MSP-like disorders: Clinical-pathological-molecular spectrum. Annals of clinical and translational neurology 18 36861178
2003 Expression and purification of Plasmodium falciparum MSP-1(42): A malaria vaccine candidate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 18 12651002
2000 A comparative study of hormonal regulation of three secretory proteins (prostatic secretory protein-PSP94, probasin, and seminal vesicle secretion II) in rat lateral prostate. Endocrinology 18 11108266
1980 Cleavage of single strand oligonucleotides and bacteriophage phi X174 DNA by Msp I endonuclease. The Journal of biological chemistry 18 6159356
2020 Conferring root-knot nematode resistance via host-delivered RNAi-mediated silencing of four Mi-msp genes in Arabidopsis. Plant science : an international journal of experimental plant biology 17 32771150
2019 The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils. Infection and immunity 17 31481407
2012 Promoter variants in the MSMB gene associated with prostate cancer regulate MSMB/NCOA4 fusion transcripts. Human genetics 17 22661295
2006 Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding. Biochemical and biophysical research communications 17 16759641
2016 Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent. Malaria journal 16 27663527
2014 MSP: an emerging player in metabolic syndrome. Cytokine & growth factor reviews 16 25466635
2009 Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer. Human genetics 16 19644707
2006 Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling. Anti-cancer drugs 16 16550001
2006 Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion. Peptides 16 16713025
2020 The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular oncology 15 32484599
2016 MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Experimental & molecular medicine 15 27609031
2014 Characterization of Treponema denticola mutants defective in the major antigenic proteins, Msp and TmpC. PloS one 15 25401769
2010 Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. Journal of molecular biology 15 20184897
2010 Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific. Asian journal of andrology 15 20676114
2009 Mutation analysis of the MSMB gene in familial prostate cancer. British journal of cancer 15 19997100
2001 The manganese stabilizing protein (MSP) and the control of O2 evolution in the unicellular, diazotrophic cyanobacterium, Cyanothece sp. ATCC 51142. Biochimica et biophysica acta 15 11245804
1993 The potential use of prostatic secretory protein of 94 amino acid residues (PSP94) as a serum marker for prostatic tumor. Urological research 15 7688168