Affinage

MRPL13

Large ribosomal subunit protein uL13m · UniProt Q9BYD1

Round 2 corrected
Length
178 aa
Mass
20.7 kDa
Annotated
2026-04-28
86 papers in source corpus 23 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MRPL13 is a structural component of the mammalian mitochondrial large ribosomal subunit (mt-LSU), incorporated during late-stage mt-LSU assembly, as directly visualized by high-resolution cryo-EM (PMID:25278503, PMID:28892042). Beyond its structural role in the mitoribosome, MRPL13 promotes K48-linked ubiquitination and degradation of SLC25A6 (ANT3), thereby inhibiting mitochondrial permeability transition pore opening, maintaining oxidative phosphorylation, and suppressing cytochrome c release (PMID:40841355). MRPL13 depletion activates the mitochondrial unfolded protein response, depletes HSP60 and CLPP, impairs trophoblast migration, and enhances autophagy, with reduced MRPL13 expression observed in early-onset preeclampsia placentas (PMID:41630109). Note: the cytoplasmic ribosomal paralog RPL13a (eL13/L13a) possesses a well-characterized extraribosomal function as the translational silencing component of the IFN-γ-activated GAIT complex, where DAPK–ZIPK-dependent Ser77 phosphorylation releases it from 60S subunits to repress GAIT-element-bearing inflammatory mRNAs via eIF4G interaction (PMID:14567916, PMID:18995835, PMID:17218275).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1994 Medium

    Initial cloning of both the yeast mitochondrial MRP-L13 and the rat cytoplasmic L13a established that two distinct genes encode ribosomal L13 proteins in separate compartments, with yeast MRP-L13 disruption reducing but not abolishing non-fermentable growth.

    Evidence Gene cloning, disruption, and protein sequencing in yeast; cDNA cloning and sequence analysis in rat

    PMID:7954901 PMID:8119894

    Open questions at the time
    • No mammalian mitochondrial MRPL13 functional data yet
    • Yeast disruption phenotype is partial — redundancy or residual function unexplored
  2. 2003 High

    The discovery that cytoplasmic L13a is released from 60S subunits upon IFN-γ stimulation and silences ceruloplasmin mRNA translation via the GAIT element established the paradigm of extraribosomal translational control by a ribosomal protein, though this concerns the cytoplasmic paralog RPL13a rather than mitochondrial MRPL13.

    Evidence Genetic screen, in vitro translation assay, ribosomal subunit fractionation, phosphorylation analysis in human monocytic cells

    PMID:14567916

    Open questions at the time
    • Phosphorylation site not yet mapped
    • Identity of kinase unknown
    • Relationship to mitochondrial MRPL13 unaddressed
  3. 2007 High

    The mechanism of GAIT-mediated silencing was resolved: released L13a blocks 43S ribosomal complex recruitment by binding eIF4G, and L13a knockdown showed it is dispensable for global translation but essential for rRNA methylation and GAIT silencing.

    Evidence IRES reporter assays, 43S assembly assays, eIF4G interaction studies; stable shRNA knockdown with metabolic labeling and polysome analysis

    PMID:17218275 PMID:17921318

    Open questions at the time
    • Structural basis of L13a–eIF4G interaction unknown
    • rRNA methylation targets not defined
  4. 2008 High

    The DAPK→ZIPK kinase cascade was identified as responsible for Ser77 phosphorylation of L13a, triggering its 60S release, with both kinase mRNAs containing GAIT elements creating negative feedback.

    Evidence Kinase cascade assays, Ser77 site-directed mutagenesis, ribosome fractionation, GAIT reporter assays

    PMID:18995835

    Open questions at the time
    • Whether this cascade operates in non-monocytic cells unknown
    • Structural basis of phosphorylation-dependent release not resolved
  5. 2013 High

    In vivo macrophage-specific L13a knockout demonstrated that GAIT-mediated translational control of chemokines is physiologically essential for resolving inflammation, as KO mice develop lethal endotoxemia; separately, Arg68 was shown critical for 60S incorporation during 90S preribosome maturation but dispensable for GAIT function.

    Evidence Conditional KO mice with LPS challenge, ELISA, polyribosome profiling; site-directed mutagenesis with ribosome fractionation and nucleolar assays

    PMID:23460747 PMID:23689135

    Open questions at the time
    • Whether MRPL13 (mitochondrial) also participates in translational control unknown
    • GAIT target repertoire not comprehensively defined
  6. 2014 High

    Cryo-EM at 3.4 Å directly visualized MRPL13 as a structural subunit of the human mitochondrial large ribosomal subunit, and L13a was shown to act as an antiviral factor silencing RSV matrix protein translation via a VAIT complex, while L13a-dependent translational control was found to protect against atherosclerosis in ApoE-null mice.

    Evidence Single-particle cryo-EM of human mt-LSU; RSV growth assays with L13a KD/KO; double-KO atherosclerosis model with histology and polyribosome profiling

    PMID:24436370 PMID:24899178 PMID:25278503

    Open questions at the time
    • MRPL13's contacts within the mitoribosome not functionally characterized
    • Whether MRPL13 has extraribosomal roles analogous to RPL13a unknown
  7. 2017 High

    Cryo-EM of late-stage mt-LSU assembly intermediates revealed the sequential timing of MRPL13 incorporation during mitoribosome biogenesis, establishing its position in the assembly pathway.

    Evidence Cryo-EM of native assembly intermediates at ~3 Å from human cells

    PMID:28892042

    Open questions at the time
    • Assembly factors recruiting MRPL13 not identified
    • Consequences of MRPL13 depletion on mt-LSU assembly not tested
  8. 2019 High

    Mutually exclusive residues in the eukaryote-specific C-terminal extension of L13a were mapped for ribosomal incorporation versus GAIT silencing, with Arg169/Lys170/Lys171 specifically required for GAIT function; separately, RPL13 (cytoplasmic) mutations were linked to spondyloepimetaphyseal dysplasia in humans with altered ribosome profiles.

    Evidence Mutagenesis of C-terminal extension with in vitro translation and ribosome fractionation; patient cell ribosome profiling and erythroid assays

    PMID:31308261 PMID:31630789

    Open questions at the time
    • Whether MRPL13 C-terminal domain has analogous dual function unknown
    • SEMD mechanism not fully defined at molecular level
  9. 2020 Medium

    RPL13 SEMD mutations were further characterized showing reduced eL13–eL28 co-localization, increased 60S:80S ratio, and attenuated global translation; an rpl13 zebrafish KO confirmed a role in skeletogenesis.

    Evidence Patient fibroblasts with ribosome profiling and co-localization; CRISPR zebrafish model

    PMID:32916022

    Open questions at the time
    • Whether MRPL13 contributes to skeletal phenotypes is unexplored
    • Mechanism by which mutant eL13 alters translation dynamics not resolved
  10. 2025 Medium

    Extraribosomal functions of MRPL13 in mitochondria were uncovered: MRPL13 promotes K48-ubiquitination of SLC25A6 to suppress mPTP opening and maintain OXPHOS; separately, MRPL13 depletion activates UPRmt, depletes HSP60/CLPP, impairs trophoblast function, and is reduced in preeclampsia; L13a KO macrophages show dysregulated polarization by scRNA-seq.

    Evidence Co-IP and ubiquitination assays in ovarian cancer cells with mitochondrial functional readouts and xenograft; siRNA in trophoblast lines with proteomics of preeclampsia placentas; myeloid-specific L13a KO with scRNA-seq

    PMID:40631353 PMID:40841355 PMID:41630109

    Open questions at the time
    • Whether MRPL13 directly mediates ubiquitination or recruits an E3 ligase is unknown
    • UPRmt mechanism linking MRPL13 to HSP60/CLPP not defined
    • Single-lab findings for SLC25A6 interaction await independent validation

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include: whether MRPL13 has translation-independent signaling roles distinct from mitoribosomal function, the identity of the E3 ubiquitin ligase mediating SLC25A6 degradation, and whether MRPL13 mutations cause mitochondrial disease in humans.
  • No MRPL13-specific Mendelian disease identified
  • No reconstituted structural model of MRPL13–SLC25A6 interaction
  • Consequences of MRPL13 loss on mitochondrial translation not directly measured

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005739 mitochondrion 4 GO:0005840 ribosome 2
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 1 R-HSA-5357801 Programmed Cell Death 1
Partners
SLC25A6
Complex memberships
mitochondrial large ribosomal subunit (mt-LSU)

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Human ribosomal protein L13a is released from the 60S ribosomal subunit upon IFN-γ stimulation, becomes phosphorylated, and in its released form binds the GAIT element in the 3′-UTR of ceruloplasmin mRNA to silence its translation. L13a was identified as the GAIT component by genetic screen and its in vitro translational inhibitory activity was demonstrated with recombinant protein. Genetic screen for 3′-UTR binding proteins, in vitro translation assay with recombinant protein, ribosomal subunit fractionation, phosphorylation analysis Cell High 14567916
2007 Released L13a blocks translation of GAIT element-containing mRNAs by interacting with eIF4G, preventing 43S ribosomal complex recruitment to the mRNA without disrupting eIF4F complex formation. Sensitivity required IRES elements dependent on eIF4G but not eIF4F-independent IRESs. IRES-driven reporter assays, 43S assembly assays, protein interaction studies with eIF4G Molecular cell High 17218275
2007 L13a-deficient human U937 cells (>98% knockdown) show rescued ceruloplasmin mRNA translation from IFN-γ-mediated silencing, reduced rRNA methylation, and impaired cap-independent IRES-mediated translation, but normal global translation, rRNA processing, polysome formation, translational fidelity, and cell proliferation, establishing L13a as dispensable for canonical ribosome function but essential for rRNA methylation and GAIT-mediated silencing. Stable shRNA knockdown, metabolic labeling, ribosome profiling, polysome analysis, IRES reporter assays RNA (New York, N.Y.) High 17921318
2008 IFN-γ activates a kinase cascade in which DAPK phosphorylates and activates ZIPK, which in turn phosphorylates L13a at Ser77, causing its release from the 60S ribosomal subunit and subsequent translational silencing of GAIT element-bearing mRNAs. Both DAPK and ZIPK mRNAs contain functional GAIT elements, creating a negative-feedback module. Kinase cascade assays, site-directed mutagenesis of Ser77, ribosome fractionation, GAIT element reporter assays Molecular cell High 18995835
2013 Macrophage-specific knockout of L13a in mice abrogates translational control of several chemokines (CXCL13, CCL22, CCL8, CCR3), leading to severe LPS-induced endotoxemia with widespread macrophage infiltration, tissue injury, and reduced survival. Macrophages from KO mice fail to form L13a-dependent RNA-binding complexes on target mRNAs and show increased polyribosomal association of these mRNAs. Conditional macrophage-specific L13a knockout mice, LPS endotoxemia model, ELISA for chemokines, polyribosome profiling, RNA-protein binding assays Journal of immunology High 23460747
2013 Arginine 68 of L13a is essential for rRNA binding and incorporation into the 60S ribosomal subunit. Incorporation occurs during maturation of the 90S preribosome in the nucleolus and is required for rRNA methylation within the 90S complex. Mutations abolishing ribosomal incorporation do not affect L13a phosphorylation or its extraribosomal GAIT silencing function. Site-directed mutagenesis, ribosome fractionation, nucleolar localization assays, rRNA methylation assays, in vitro GAIT translation assays Molecular and cellular biology High 23689135
2014 L13a acts as an antiviral innate immune factor: upon RSV infection, L13a is released from the 60S subunit and forms a VAIT (RSV-activated inhibitor of translation) complex that recognizes a GAIT-like hairpin in the 3′-UTR of RSV matrix (M) protein mRNA, silencing its translation and suppressing viral replication. RSV growth was enhanced in L13a-deficient cells, and M mRNA showed increased polyribosomal association. L13a KD in multiple cell lines and L13a KO macrophages, RSV growth assays, polyribosome profiling, RNA-protein interaction studies, in silico RNA structure prediction, translational reporter assays Journal of virology High 24899178
2014 Macrophage-specific L13a knockout on an apoE-deficient background results in significantly increased atherosclerosis, thinner smooth muscle cell media, larger macrophage plaque area, higher plasma inflammatory cytokines, and elevated polyribosomal abundance of target mRNAs in macrophages, demonstrating that L13a-dependent translational control protects against atherosclerosis. Double knockout mice (L13a flox/ApoE-/-), high-fat diet atherosclerosis model, aortic sinus histology, en face aorta analysis, ELISA, polyribosome profiling Arteriosclerosis, thrombosis, and vascular biology High 24436370
2015 Myeloid-specific L13a KO mice subjected to dextran sodium sulfate show severe colitis with accelerated weight loss, rectal bleeding, colon shortening, reduced survival, elevated inflammatory cytokines/chemokines, and abrogated translational silencing of pro-inflammatory mRNAs, revealing L13a-dependent translational control as an endogenous defense against ulcerative colitis. Myeloid-specific L13a KO mice, DSS colitis model, histopathology, ELISA, polyribosome profiling, cytokine quantification Cellular & molecular immunology High 26166763
2019 Mutually exclusive amino acid residues in the eukaryote-specific C-terminal extension of human L13a (Tyr149–Val203) are responsible for either ribosomal incorporation or GAIT-mediated translational silencing. Specifically, mutation of Arg169, Lys170, and Lys171 to Ala abrogates GAIT silencing but not ribosomal incorporation. The C-terminal helix alone is sufficient to silence translation of GAIT element-containing mRNAs in vitro. Multiple complex nuclear import signals are present within L13a. Biochemical mutagenesis of C-terminal extension variants, in vitro translation assays, ribosome fractionation, cellular immunofluorescence RNA (New York, N.Y.) High 31308261
2011 SRY interacts with ribosomal protein L13a (RPL13a) via the HMG box domain of SRY, as identified by yeast two-hybrid. SRY, RPL13a, and RPS7 co-localize in nuclear speckles in COS1 cells. Yeast two-hybrid, co-localization by immunofluorescence in COS1 cells Cell biology international Low 21114473
2019 RPL13 de novo missense and splice variants (causing 18-amino acid insertions) in humans cause spondyloepimetaphyseal dysplasia (SEMD). The insertion-containing protein is stably expressed and incorporated into 60S subunits similarly to wild-type, with no major pre-rRNA processing disturbance, but erythroid proliferation and ribosome profiles on sucrose gradients are altered, suggesting altered translation dynamics. RPL13 is expressed at high levels in chondrocytes and osteoblasts. Patient cell studies, sucrose gradient ribosome profiling, erythroid proliferation assays, immunohistochemistry of mouse growth plates American journal of human genetics Medium 31630789
2020 RPL13 missense mutations in patient-derived fibroblasts causing SEMD show normal eL13 expression and subcellular localization but reduced co-localization with eL28 (p<0.001), an increased 60S:80S subunit ratio (p=0.007), and attenuated global translation (p=0.017). An rpl13 CRISPR-Cas9 zebrafish model exhibits cartilage deformities, confirming the role of eL13 in skeletogenesis. Patient-derived fibroblast studies, co-localization assays, sucrose gradient ribosome profiling, translation assays, CRISPR-Cas9 zebrafish model Journal of bone and mineral research Medium 32916022
2021 MRPL13 (mitochondrial ribosomal protein L13) knockdown in breast cancer cells significantly suppresses phosphorylation of AKT and mTOR, inhibits proliferation, migration, and EMT-related gene expression; these effects are partially rescued by the PI3K agonist 740Y-P, placing MRPL13 upstream of PI3K/AKT/mTOR signaling in breast cancer cells. RNAi-mediated knockdown, proliferation and migration assays, Western blotting for p-AKT and p-mTOR, PI3K agonist rescue experiment Cancer management and research Medium 33658859
2022 In BRAF-inhibitor-treated melanoma cells, L13a-dependent GAIT-like translational repression of HuR mRNA (via a GAIT-like motif near its polyadenylation site PAS2) contributes to HuR insufficiency. Knockdown of L13a or inhibition of the DAPK1-ZIPK axis reduces the proportion of HuR-low cells and attenuates adaptive resistance to BRAF inhibition. Overexpression of wild-type and mutant HuR mRNA constructs, in vivo RNA-protein interaction assays, L13a KD, DAPK1-ZIPK inhibition, BRAF inhibitor treatment Biochemical and biophysical research communications Medium 35970041
2014 The human mitochondrial large ribosomal subunit structure determined by cryo-EM to 3.4 Å resolution includes MRPL13 as one of 48 proteins, including 21 mitoribosome-specific proteins, establishing MRPL13 as a structural component of the mammalian mitoribosome. Single-particle cryo-electron microscopy at 3.4 Å resolution Science High 25278503
2017 Cryo-EM structures of two late-stage human mitoribosomal large subunit assembly intermediates (~3 Å) reveal the sequential incorporation of proteins including MRPL13 during the final steps of mt-LSU maturation, providing insight into the timing of rRNA folding and protein incorporation. Cryo-EM of native assembly intermediates isolated from human cells, ~3 Å resolution Nature structural & molecular biology High 28892042
2025 MRPL13 specifically interacts with SLC25A6 (ANT3) and promotes its degradation via K48-linked ubiquitination. This interaction inhibits mitochondrial permeability transition pore (mPTP) opening, preventing cytochrome c release, suppressing cell death, and maintaining OXPHOS and ATP levels in ovarian cancer cells. MRPL13 knockdown impairs OXPHOS, increases ROS, causes mitochondrial depolarization and mPTP opening. Co-immunoprecipitation, ubiquitination assays (K48-linkage), MRPL13 overexpression/knockdown, mitochondrial membrane potential assays, ROS measurement, ATP measurement, cytochrome c release assay, in vivo xenograft Cell death & disease Medium 40841355
2025 Knockdown of MRPL13 in trophoblast cells (HTR8/SVneo, BeWo) aggravates mitochondrial unfolded protein response (UPRmt), depletes HSP60 and CLPP, promotes mitochondrial dysfunction, inhibits cell migration, and enhances autophagy, with effects exacerbated under ER stress. MRPL13 expression is significantly reduced in early-onset preeclampsia placental tissues. siRNA knockdown in trophoblast cell lines, proteomics of EOPE vs. control placentas, Western blotting, immunofluorescence, tunicamycin-induced ER stress, migration assays, autophagy quantification Reproduction (Cambridge, England) Medium 41630109
2025 Myeloid-specific L13a KO macrophages show enhanced expression of both M1 and M2 markers and deviate from expected polarization responses, with altered phosphorylation of signaling molecules. Single-cell RNA sequencing reveals widespread changes in gene expression and diverse macrophage subpopulations; CD4+ T cells from KO animals show increased Th1 and Th2 signature genes. Myeloid-specific L13a KO mice, ex vivo BMDM differentiation, bulk and single-cell RNA sequencing, phosphoproteomics of signaling molecules, T cell gene expression analysis Journal of leukocyte biology Medium 40631353
1994 Rat ribosomal protein L13a (202 amino acids, Mr 23,330) was sequenced from cDNA and found to contain a leucine zipper-like motif at its N-terminus and a potential basic region-leucine zipper (bZIP)-like element in its C-terminal region, as well as short repeated sequences. The mouse tum- transplantation antigen P198 is a mutant of the mouse homolog of rat L13a. cDNA cloning, nucleotide sequencing, deduced amino acid sequence, Southern blot for gene copy number The Journal of biological chemistry Medium 8119894
1994 The yeast nuclear gene MRP-L13 encodes the large subunit mitochondrial ribosomal protein YmL13, preceded by an 86-amino-acid mitochondrial signal peptide (the longest known among yeast mitoribosomal proteins). The gene is single-copy on chromosome XI, its transcription is repressed by glucose, and disruption reduces but does not abolish growth on non-fermentable carbon sources, indicating the protein is not strictly essential for mitochondrial function. Gene cloning, sequence analysis, N-terminal protein sequencing of purified YmL13, gene disruption by LEU2 insertion, growth assays on fermentable and non-fermentable carbon sources Current genetics Medium 7954901
2024 L13a (RPL13a) in fish cells acts as a host antiviral factor against snakehead vesiculovirus (SHVV): overexpression inhibits SHVV replication while knockdown promotes it. SHVV leader RNA directly binds L13a (and RPS8), and this interaction neutralizes L13a's antiviral effect, allowing the virus to promote its own replication. RNA-protein binding assays, L13a overexpression and knockdown, SHVV replication assays, co-transfection with leader RNA Fish & shellfish immunology Low 38432538

Source papers

Stage 0 corpus · 86 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2003 Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell 275 14567916
2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nature biotechnology 266 15146197
2014 Structure of the large ribosomal subunit from human mitochondria. Science (New York, N.Y.) 262 25278503
2021 Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell metabolism 239 34800366
2011 MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell metabolism 230 21531335
2018 Mapping the Genetic Landscape of Human Cells. Cell 225 30033366
2016 Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Molecular cell 220 27499296
2016 Structure and Function of the Mitochondrial Ribosome. Annual review of biochemistry 217 27023846
2009 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science signaling 207 19738201
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2010 A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. The EMBO journal 153 20186120
2015 BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. Molecular & cellular proteomics : MCP 149 25900982
2020 A High-Density Human Mitochondrial Proximity Interaction Network. Cell metabolism 148 32877691
2019 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nature cell biology 137 31871319
2017 Structures of the human mitochondrial ribosome in native states of assembly. Nature structural & molecular biology 136 28892042
2016 SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Molecular cell 134 27591049
2021 The SARS-CoV-2 RNA interactome. Molecular cell 129 33989516
2020 PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nature chemical biology 129 32989298
2008 DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Molecular cell 127 18995835
1978 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins La, Lb, Lf, P1, P2, L13', L14, L18', L20, and L38. The Journal of biological chemistry 112 621213
2007 L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control. Molecular cell 80 17218275
1976 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. The Journal of biological chemistry 70 1002715
2007 Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation. RNA (New York, N.Y.) 67 17921318
2006 Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. International journal of molecular medicine 65 16786168
2013 The rice nuclear gene WLP1 encoding a chloroplast ribosome L13 protein is needed for chloroplast development in rice grown under low temperature conditions. Plant molecular biology 56 24132771
2013 An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. Journal of immunology (Baltimore, Md. : 1950) 53 23460747
2018 The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in Plasmodium falciparum. The Journal of biological chemistry 51 29626096
2020 Ribosomal Protein L13 Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus in a Helicase DDX3-Dependent Manner. Journal of virology 50 31619563
2012 Ribosomal protein l13a as a reference gene for human bone marrow-derived mesenchymal stromal cells during expansion, adipo-, chondro-, and osteogenesis. Tissue engineering. Part C, Methods 46 22533734
2004 P6 protein of Cauliflower mosaic virus, a translation reinitiator, interacts with ribosomal protein L13 from Arabidopsis thaliana. The Journal of general virology 39 15557250
2007 Characterization and expression during development and under environmental stress of the genes encoding ribosomal proteins L11 and L13 in Chironomus riparius. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 34 17507274
2021 MRPL13 Promotes Tumor Cell Proliferation, Migration and EMT Process in Breast Cancer Through the PI3K-AKT-mTOR Pathway. Cancer management and research 33 33658859
2014 Extraribosomal l13a is a specific innate immune factor for antiviral defense. Journal of virology 32 24899178
2021 Ribosomal Protein L13 Participates in Innate Immune Response Induced by Foot-and-Mouth Disease Virus. Frontiers in immunology 31 34093518
2014 Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation. Arteriosclerosis, thrombosis, and vascular biology 31 24436370
2019 RPL13 Variants Cause Spondyloepimetaphyseal Dysplasia with Severe Short Stature. American journal of human genetics 26 31630789
1985 Cloning and nucleotide sequencing of the genes for ribosomal proteins S9 (rpsI) and L13 (rplM) of Escherichia coli. Molecular & general genetics : MGG 24 3884974
2019 Model system identification of novel congenital heart disease gene candidates: focus on RPL13. Human molecular genetics 23 31625562
1994 A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum- transplantation antigen P198. The Journal of biological chemistry 23 8119894
1989 Chloroplast ribosomal protein L13 is encoded in the nucleus and is considerably larger than its bacterial homologue. Construction, immunoisolation, and nucleotide sequence (including transit peptide) its cDNA clone from an angiosperm. The Journal of biological chemistry 23 2644249
2015 L13a-dependent translational control in macrophages limits the pathogenesis of colitis. Cellular & molecular immunology 20 26166763
2021 MRPL13 Act as a Novel Therapeutic Target and Could Promote Cell Proliferation in Non-Small Cell Lung Cancer. Cancer management and research 19 34285575
2004 Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. Proceedings of the National Academy of Sciences of the United States of America 17 15465910
2020 Novel RPL13 Variants and Variable Clinical Expressivity in a Human Ribosomopathy With Spondyloepimetaphyseal Dysplasia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 16 32916022
1980 Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11. Biochemistry 16 6773542
2019 Draft genome sequence of a multidrug-resistant blaOXA-69-producing Acinetobacter baumannii L13 isolated from Tarim River sample in China. Journal of global antimicrobial resistance 15 31176070
1994 The yeast nuclear gene MRP-L13 codes for a protein of the large subunit of the mitochondrial ribosome. Current genetics 15 7954901
2023 Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma. Aging 13 37827692
2013 Insights into the mechanism of ribosomal incorporation of mammalian L13a protein during ribosome biogenesis. Molecular and cellular biology 13 23689135
2005 Insertional inactivation of the L13a ribosomal protein gene of Drosophila melanogaster identifies a new Minute locus. Gene 12 16326033
1994 The primary structure of rat ribosomal protein L13. Biochemical and biophysical research communications 11 8198561
2017 Complete genome sequence of Pseudomonas brassicacearum strain L13-6-12, a biological control agent from the rhizosphere of potato. Standards in genomic sciences 10 28078051
2004 Molecular characterization of a light-responsive gene, breast basic conserved protein 1 (OsiBBC1), encoding nuclear-localized protein homologous to ribosomal protein L13 from Oryza sativa indica. Biochimica et biophysica acta 10 14746913
2011 SRY interacts with ribosomal proteins S7 and L13a in nuclear speckles. Cell biology international 8 21114473
1993 Involvement of calcium-dependent cysteine protease in fibronectin-induced chemotactic migration of NIH-L13 fibroblasts. Biochemistry and molecular biology international 7 8364405
1991 Chloroplast ribosomal protein L15, like L1, L13 and L21, is significantly larger than its E. coli homologue. FEBS letters 6 2037044
1999 UVB and gamma-radiation induce the expression of mRNAs encoding the ribosomal subunit L13A in rat keratinocytes. Photochemistry and photobiology 5 10483362
2023 Clinical, genetic and structural delineation of RPL13-related spondyloepimetaphyseal dysplasia suggest extra-ribosomal functions of eL13. NPJ genomic medicine 4 37993442
1998 Characterization of a Schistosoma mansoni homologue of the gene encoding the breast basic conserved protein 1/L13 ribosomal protein. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 4 9854818
1982 The gene for ribosomal protein L13, rplM, is located near argR, at about 70 minutes on the Escherichia coli chromosomal linkage map. Journal of bacteriology 4 7035437
2023 Evolution of clinical and radiological presentations of spondyloepimetaphyseal dysplasia, RPL13-related: Description of 11 further cases. Clinical genetics 3 37121912
2022 Inhibition of the DAPKs-L13a axis prevents a GAIT-like motif-mediated HuR insufficiency in melanoma cells. Biochemical and biophysical research communications 3 35970041
2020 Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer. Journal of applied biomedicine 3 34907725
2002 The production of anti-hexapeptide antibodies which recognize the S7, L6 and L13 ribosomal proteins of Escherichia coli. Journal of peptide science : an official publication of the European Peptide Society 3 11931584
2024 Bombyx mori RPL13 participates in UV-induced DNA damage repair of B. mori nucleopolyhedrovirus through interaction with Bm65. Insect molecular biology 2 38801334
2025 Beyond the Known: Expanding the Clinical and Genetic Spectrum of Rare RPL13-Related Spondyloepimetaphyseal Dysplasia. International journal of molecular sciences 1 40725227
2024 Snakehead vesiculovirus (SHVV) leader RNA interacts with host antiviral factors RPS8 and L13a and promotes virus replication. Fish & shellfish immunology 1 38432538
2023 In silico analyses of pan-squamous cell carcinoma unveiled the immunological implications of MRPL13, which had previously been under-recognized. Heliyon 1 38187248
2019 Mutually exclusive amino acid residues of L13a are responsible for its ribosomal incorporation and translational silencing leading to resolution of inflammation. RNA (New York, N.Y.) 1 31308261
2026 MRPL13 deficiency triggers trophoblast mitochondrial unfolded protein response in early-onset preeclampsia. Reproduction (Cambridge, England) 0 41630109
2025 Adaptive responses of Rhodococcus aetherivorans L13 to oligotrophy: genome and transcriptomic analysis. Current genetics 0 40220062
2025 Myeloid-specific deficiency of ribosomal protein L13a alters macrophage polarity and diversity during differentiation from bone marrow. Journal of leukocyte biology 0 40631353
2025 MRPL13 enhances mitochondrial function and promotes tumor progression in ovarian cancer by inhibiting mPTP opening via SLC25A6. Cell death & disease 0 40841355
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