Affinage

MMP3

Stromelysin-1 · UniProt P08254

Length
477 aa
Mass
54.0 kDa
Annotated
2026-06-10
100 papers in source corpus 33 papers cited in narrative 33 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP3 (stromelysin-1) is a secreted, TIMP-sensitive extracellular metalloprotease that remodels extracellular matrix and processes signaling substrates to drive tissue remodeling, inflammation, and tumor progression across many cell types (PMID:10428026, PMID:35176662). In epithelial systems it is a potent inducer of epithelial-to-mesenchymal transition and tumor initiation, an activity blocked by TIMP1 co-expression, and it amplifies invasive and metastatic programs in part by stimulating the tumorigenic Rac1b splice isoform in pancreatic cancer cells (PMID:10428026, PMID:24850902). MMP3 supports tumor cell-intrinsic growth signaling (AKT/ERK phosphorylation) and extrinsic angiogenesis, can be transferred between tumor cells via extracellular vesicles to promote proliferation, and mediates organ-specific metastasis such as brain colonization downstream of KMT2C/D loss and Notch3-driven osteoblastic bone lesions (PMID:31467432, PMID:32896761, PMID:32429403, PMID:38926506). Its substrate repertoire includes structural ECM proteins laminin and fibronectin during spiral artery remodeling, FasL (whose cleavage releases soluble FasL to trigger osteoclast apoptosis downstream of ERα), and osteopontin in nanoparticle-induced lung injury (PMID:35176662, PMID:22927007, PMID:39030581). Beyond cancer, MMP3 acts as an inflammatory mediator in activated microglia and drives psychosine-induced microglial globoid cell formation, functions as an antiadipogenic factor reversible by TIMP4, regulates aqueous humor outflow and intraocular pressure through trabecular meshwork matrix remodeling, and restrains trabecular bone mass by promoting bone resorption (PMID:18419763, PMID:23404611, PMID:27879248, PMID:28158775, PMID:35949513). MMP3 transcription is a heavily integrated node: it is directly activated by STAT3, NFATc3 (calcium/calcineurin-dependent), and NFAT1, repressed by IRF8 and by BMAL1 acting through NF-κB p65, induced epigenetically via TWIST1→TET1→5hmC and via KMT2C/D loss→KDM6A, and converges on multiple MAPK cascades including isoform-specific ERK1/ATF-2 and PKC/PKD1/MEK signaling (PMID:23967200, PMID:23625833, PMID:27013197, PMID:26008967, PMID:29276151, PMID:28220902, PMID:38926506, PMID:31536594, PMID:21867693). Its mRNA is additionally stabilized by m6A-dependent IGF2BP3 binding to promote cardiomyocyte proliferation and cardiac regeneration, and a functional 5A/6A promoter polymorphism tunes its expression level (PMID:37188676, PMID:15341739).

Mechanistic history

Synthesis pass · year-by-year structured walk · 26 steps
  1. 1999 High

    Established that MMP3 is not merely an ECM-degrading enzyme but an active driver of malignant transformation, answering whether proteolytic activity alone could initiate cancer.

    Evidence Tetracycline-regulated MMP3 transgenic mice with TIMP1 co-expression rescue and in vivo tumor assays

    PMID:10428026

    Open questions at the time
    • Identity of the TIMP1-sensitive substrate(s) initiating EMT not defined
    • Mechanism linking proteolysis to mesenchymal gene programs unresolved
  2. 2004 Medium

    Defined a functional cis-regulatory basis for inter-individual MMP3 expression by showing the 5A/6A promoter variant alters transcription factor binding and expression level.

    Evidence Population genetics with functional transcription factor binding assay and mRNA/protein quantification

    PMID:15341739

    Open questions at the time
    • Identity of the differentially-bound transcription factor not specified
    • Physiological consequence of allele-specific expression not directly tested
  3. 2008 Medium

    Showed MMP3 is an amplifier of innate immune activation, placing it within an ROS→MMP3→NF-κB/AP-1/MAPK inflammatory loop in microglia rather than acting only on matrix.

    Evidence Pharmacological MMP-3 inhibition in primary and BV2 microglia with NF-κB/AP-1/MAPK and ROS assays

    PMID:18419763

    Open questions at the time
    • Relies on pharmacological inhibition without genetic confirmation
    • Direct MMP3 substrate driving inflammatory signaling not identified
  4. 2008 High

    Demonstrated context-dependent tumor suppression by MMP3, showing that in keratinocytes it promotes differentiation and impedes tumor establishment, contrasting its mammary tumor-initiating role.

    Evidence Keratinocyte-targeted MMP3 transgenic mice, chemical carcinogenesis, and selective MMP3 inhibition in vitro

    PMID:18832569

    Open questions at the time
    • Substrate underlying pro-differentiation effect unknown
    • Determinants of the tumor-promoting versus -suppressive switch not defined
  5. 2008 Medium

    Connected metabolic enzyme signaling to MMP3 induction by mapping an AMF/PGI→Src-RhoA-PI3K→AP-1 transcriptional cascade driving hepatoma migration.

    Evidence MMP3 promoter-luciferase reporter, signaling inhibitors, Src-RhoA-PI3K Co-IP, and migration assay

    PMID:18571835

    Open questions at the time
    • Co-IP-defined complex not validated reciprocally or structurally
    • Direct AP-1 occupancy of the MMP3 promoter not shown
  6. 2013 High

    Identified FasL as a physiological MMP3 substrate and defined an ERα→MMP3→soluble FasL→osteoclast apoptosis axis linking estrogen to bone homeostasis.

    Evidence MMP3 siRNA, specific inhibitor, EGFP-FasL cleavage assay, ERαKO osteoblasts, and osteoclast co-culture

    PMID:22927007

    Open questions at the time
    • Cleavage site within FasL not mapped
    • In vivo contribution to estrogen-dependent bone protection not isolated
  7. 2013 High

    Established direct transcriptional control of MMP3 by STAT3, showing phospho-STAT3 binds the MMP3 promoter to couple heme stress to endothelial apoptosis.

    Evidence ChIP, MMP3 promoter-luciferase reporter, qRT-PCR, and TUNEL in brain microvascular endothelial cells

    PMID:23967200

    Open questions at the time
    • Single-cell-type context
    • MMP3 substrate mediating apoptosis not defined
  8. 2013 High

    Showed calcium-dependent NFATc3/calcineurin signaling directly drives MMP3 transcription in reactive astrocytes after injury, linking neural calcium signaling to matrix remodeling.

    Evidence Constitutively active NFATc3, calcium ionophore, MMP3 promoter-luciferase, cyclosporin A, and in vivo brain injury model

    PMID:23625833

    Open questions at the time
    • Direct NFATc3 occupancy of endogenous promoter not shown by ChIP
    • Functional consequence of astrocytic MMP3 on scar tissue not isolated
  9. 2013 High

    Revealed a cell-type-specific function of MMP3 in mediating psychosine-induced transformation of microglia into globoid cells, relevant to lysosomal storage disease pathology.

    Evidence MMP-3 knockout mice, chemical inhibition in primary glia, and twitcher mouse immunohistochemistry

    PMID:23404611

    Open questions at the time
    • Substrate driving multinucleation unknown
    • Reason for microglia-specific (versus macrophage) response unexplained
  10. 2014 High

    Mechanistically linked MMP3 to oncogenic signaling output by showing tumor-derived MMP3 induces Rac1b and primes the pancreatic stromal microenvironment alongside oncogenic KRAS.

    Evidence Human PDA cohort, KRAS/MMP3 transgenic mice, recombinant MMP3 treatment, invasion assays, transcriptional profiling

    PMID:24850902

    Open questions at the time
    • Mechanism by which extracellular MMP3 induces a splice isoform not resolved
    • Proteolytic versus non-proteolytic contribution not separated
  11. 2014 Medium

    Placed MMP3 downstream of a HOXA10→TGFβ2→p38 cascade in pancreatic cancer invasion, adding a developmental transcription factor to its upstream regulators.

    Evidence HOXA10 knockdown/overexpression, TGFβ2 neutralization, p38 inhibitor, and invasion assays

    PMID:24464212

    Open questions at the time
    • Direct transcriptional mechanism on MMP3 promoter not shown
    • Single lab without in vivo validation
  12. 2015 Medium

    Defined IRF8 as a direct transcriptional repressor of MMP3 and showed MMP3 is the effector of IRF8-loss-driven metastasis, establishing an inverse IRF8-MMP3 axis.

    Evidence IRF8 loss/gain, MMP3 siLencing epistasis, and orthotopic mammary carcinoma lung metastasis model

    PMID:26008967

    Open questions at the time
    • Direct IRF8 promoter binding not demonstrated
    • Cell-intrinsic substrate driving metastasis unidentified
  13. 2016 Medium

    Established NFAT1 (NFATc2) as a direct positive transcriptional regulator of MMP3 promoting melanoma growth and metastasis, extending NFAT-family control of MMP3.

    Evidence NFAT1 silencing/overexpression/rescue, microarray, and in vivo tumor and metastasis models

    PMID:27013197

    Open questions at the time
    • Direct promoter occupancy not shown
    • Single lab
  14. 2016 High

    Identified MMP3 as a TIMP4-reversible antiadipogenic factor with sex-dependent regulation, expanding its physiological roles into metabolic tissue.

    Evidence 3T3-L1 overexpression, rhMMP3/rhTIMP4 treatment of human preadipocytes, enzymatic activity, and sex-stratified HFD mice

    PMID:27879248

    Open questions at the time
    • Substrate mediating adipogenic blockade not identified
    • Basis of sex-dependent regulation unresolved
  15. 2017 Medium

    Defined a circadian/inflammatory repression mechanism in which BMAL1 normally restrains MMP3 transcription via control of NF-κB p65 phosphorylation, linking clock loss to skeletal pathology.

    Evidence BMAL1-deficient mice, RNA-seq, p65 phosphorylation Western blot, Mmp3 KO, and human patient samples

    PMID:29276151

    Open questions at the time
    • Direct p65 occupancy of MMP3 promoter not shown
    • Single lab
  16. 2017 High

    Revealed an epigenetic mode of MMP3 activation in which TWIST1 acts indirectly through TET1-mediated 5hmC deposition at the MMP3 promoter rather than direct binding.

    Evidence TWIST1 transfection, promoter 5hmC mapping, TET1 induction, and Tet triple-KO fibroblasts with OA tissue context

    PMID:28220902

    Open questions at the time
    • How 5hmC at the promoter mechanistically increases transcription not resolved
    • Transcription factor reading the demethylated promoter not identified
  17. 2019 Medium

    Defined an isoform-specific ERK1/ATF-2/MMP3 axis for IL-1β-induced MMP3 in dermal fibroblasts, resolving which ERK isoform couples to ATF-2.

    Evidence ERK1- and ERK2-specific siRNA, ERK and ATF-2 inhibitors, and phosphorylation Western blot

    PMID:31536594

    Open questions at the time
    • Direct ATF-2 promoter binding not mapped
    • Single cell type
  18. 2019 High

    Established a Notch3→MMP-3 axis governing osteoblastic bone lesion phenotypes in prostate cancer metastasis, with MMP3 inhibition rescuing the phenotype.

    Evidence Notch3 gain/loss in tibia xenografts, MMP-3 inhibitor rescue, osteoblast/osteoclast differentiation assays, clinical samples

    PMID:31467432

    Open questions at the time
    • Substrate mediating osteoblastogenesis not identified
    • Direct transcriptional mechanism downstream of Notch3 not shown
  19. 2020 Medium

    Separated intrinsic and extrinsic tumor functions of MMP3 by showing it sustains AKT/ERK growth signaling and tumor vascularization in prostate cancer.

    Evidence MMP-3 siRNA ablation, AKT/ERK Western blot, in vivo tumor growth, and endothelial tube formation

    PMID:32896761

    Open questions at the time
    • Mechanism connecting secreted protease to intracellular AKT/ERK unresolved
    • Substrate driving angiogenesis not defined
  20. 2020 High

    Demonstrated that MMP3 protein can be transferred between tumor cells via extracellular vesicles to drive proliferation, a non-autonomous mode of tumor promotion.

    Evidence CRISPR/Cas9 MMP3 KO, 3D tumoroids, EV isolation and fluorescent transfer, and MMP3-enriched EV rescue

    PMID:32429403

    Open questions at the time
    • Mechanism of MMP3 loading into EVs unknown
    • Whether EV-delivered MMP3 acts intra- or extracellularly not resolved
  21. 2021 Medium

    Positioned MMP3 as the effector of a GBP5→Src/ERK1/2 axis promoting glioblastoma proliferation and invasion.

    Evidence GBP5 overexpression/RNAi, in vitro invasion assays, in vivo GBM model, and pathway Western blots

    PMID:33608513

    Open questions at the time
    • Direct transcriptional control of MMP3 not shown
    • Single lab
  22. 2022 Medium

    Identified decidual macrophages as the dominant MMP3 source and showed MMP3 degrades laminin and fibronectin to enable spiral artery remodeling in early pregnancy.

    Evidence Decidual macrophage conditioned medium, MMP array, immunohistochemistry, ex vivo chorionic plate artery model, and MMP3 inhibitor

    PMID:35176662

    Open questions at the time
    • Direct in vivo requirement during human pregnancy not testable in this model
    • Trigger of macrophage MMP3 production not defined
  23. 2022 Medium

    Showed MMP3 restrains trabecular bone mass by promoting bone resorption, with a human promoter polymorphism tuning expression and BMD.

    Evidence Mmp3 KO mice, ovariectomy model, micro-CT, histomorphometry, promoter-luciferase reporter, and human cohort

    PMID:35949513

    Open questions at the time
    • Molecular substrate driving resorption not identified
    • Mechanism linking MMP3 to osteoclast activity not resolved
  24. 2023 High

    Revealed post-transcriptional control of MMP3 via m6A-dependent IGF2BP3 mRNA stabilization, linking MMP3 to cardiomyocyte proliferation and cardiac regeneration.

    Evidence IGF2BP3 gain/loss in mice, MeRIP m6A binding, mRNA stability assays, and cardiac injury/regeneration model

    PMID:37188676

    Open questions at the time
    • MMP3 substrate driving cardiomyocyte proliferation not identified
    • m6A site on MMP3 mRNA not mapped
  25. 2024 High

    Defined an epigenetic metastasis pathway in which KMT2C/D loss enables KDM6A-driven MMP3 upregulation to promote brain metastasis, providing a druggable axis.

    Evidence KMT2C/D KO mice, ChIP-seq for histone marks and KDM6A, KDM6A inhibition, Mmp3 siRNA, in vivo brain metastasis, and human TNBC

    PMID:38926506

    Open questions at the time
    • Substrate mediating brain colonization not identified
    • How KDM6A is recruited specifically to the Mmp3 locus not resolved
  26. 2024 Medium

    Identified osteopontin as an MMP3 substrate and established MMP3 as a mediator of nanoparticle-induced lung inflammation and fibrosis.

    Evidence In vivo MMP-3 knockdown, Nano-CuO exposure, bronchoalveolar lavage, fibrosis staining, hydroxyproline, and cleaved OPN assay

    PMID:39030581

    Open questions at the time
    • OPN cleavage site not mapped
    • Direct versus indirect contribution to fibrosis not fully separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular determinants that switch MMP3 between tumor-promoting and tumor-suppressive behavior, and the specific physiological substrates underlying most of its non-cancer roles, remain undefined.
  • Substrate repertoire largely uncharacterized beyond FasL, OPN, laminin, and fibronectin
  • Structural basis of substrate selection not addressed
  • Rules governing context-dependent oncogenic versus suppressive output unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 3 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-1643685 Disease 3
Partners
FASLGIGF2BP3KDM6ANFATC3SPP1STAT3TIMP1TIMP4

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 MMP3/stromelysin-1 (Str1) expression in phenotypically normal mammary epithelial cells promotes epithelial-to-mesenchymal transition and formation of invasive mesenchymal-like tumors in vivo; this tumor-initiating activity is blocked by co-expression of a TIMP1 transgene, placing MMP3 upstream of TIMP1-sensitive proteolytic events in mammary carcinogenesis. Transgenic mouse model with tetracycline-regulated MMP3 expression and TIMP1 co-expression; in vivo tumor assays; genomic analysis Cell High 10428026
2008 MMP3 functions as an inflammatory mediator in activated microglia: inhibition of MMP-3 suppresses LPS-induced iNOS expression, pro-inflammatory cytokine production, and activities of NF-κB, AP-1, and MAPK in microglia. Cross-talk exists between ROS and MMP-3, with ROS acting as an early signaling inducer upstream of MMP-3 induction. Pharmacological MMP inhibition in primary cultured microglia and BV2 microglial cells; NF-κB/AP-1/MAPK activity assays; ROS inhibition experiments Journal of neurochemistry Medium 18419763
2013 ERα signaling in osteoblasts upregulates MMP3 expression, and MMP3 then cleaves and solubilizes osteoblast-expressed FasL; soluble FasL drives osteoclast apoptosis. Specific MMP3 inhibition or MMP3 siRNA knockdown blocks FasL cleavage and prevents E2-induced osteoclast apoptosis, establishing a ERα→MMP3→FasL cleavage→osteoclast apoptosis axis. MMP3 siRNA knockdown; specific MMP3 inhibitor; EGFP-FasL fluorescence cleavage assay; conditioned media experiments; calvarial organ cultures; ERαKO mouse osteoblasts; osteoclast–osteoblast co-culture Journal of bone and mineral research High 22927007
2014 Tumor cell-derived MMP3 stimulates expression of Rac1b (a tumorigenic splice isoform of Rac1) in pancreatic cancer cells, increases cellular invasiveness, and activates tumorigenic transcriptional profiles. In transgenic mice, MMP3 co-expression with activated KRAS in pancreatic acinar cells stimulates metaplasia and immune cell infiltration, priming the stromal microenvironment. Human PDA tissue cohort analysis; transgenic mouse models; recombinant MMP3 treatment of cultured pancreatic cancer cells; invasion assays; transcriptional profiling Molecular cancer research High 24850902
2016 NFAT1 (NFATc2) directly transcriptionally regulates MMP3 expression in melanoma cells; NFAT1 depletion reduces MMP3 expression, NFAT1 overexpression induces it, and restoration of NFAT1 recovers MMP3 to baseline. MMP3 promotes melanoma tumor growth and lung metastasis in vivo. Stable NFAT1 silencing; microarray; NFAT1 overexpression/rescue experiments; in vivo tumor and metastasis models Cancer research Medium 27013197
2017 Decreased MMP-3 activity is detected in glaucomatous aqueous humor compared to controls. AAV-mediated MMP-3 expression in corneal endothelium increases aqueous humor MMP-3 concentration and activity, increases outflow facility, and decreases intraocular pressure in mice. MMP-3 remodels extracellular matrix components in the trabecular meshwork/Schlemm's canal pathway. AAV-2/9 intracameral inoculation; MMP-3 enzymatic activity assay; intraocular pressure measurement; transendothelial resistance assay; transmission electron microscopy of matrix remodeling Human molecular genetics High 28158775
2004 A single base pair insertion/deletion variant in the MMP3 promoter (5A/6A, located 1608 bp from the transcription start site) alters transcription factor binding and influences levels of MMP3 mRNA and protein, with the 5A allele associated with higher expression. Positive selection increased the frequency of the high-expression (5A) allele in European populations approximately 24,000 years ago. Phylogenetic and population genetic analysis; functional transcription factor binding assay; mRNA/protein quantification Current biology Medium 15341739
2013 Psychosine (galactosylsphingosine) induces MMP-3 expression and production in primary microglia, and MMP-3 mediates morphological transformation of microglia into multinucleated globoid cells. Genetic ablation or chemical inhibition of MMP-3 prevents psychosine-induced globoid cell formation. This process is microglia-specific; peripheral macrophages do not respond similarly. MMP-3 knockout mice; chemical MMP-3 inhibition; primary glial cultures; psychosine treatment; immunohistochemistry in twitcher mice Glia High 23404611
2013 Phosphorylated STAT3 directly binds to the MMP3 promoter in human brain microvascular endothelial cells and transcriptionally activates MMP3 expression. Heme-induced STAT3 activation leads to MMP3 upregulation and contributes to endothelial cell apoptosis. Chromatin immunoprecipitation (ChIP); luciferase reporter assay with MMP3 promoter construct; qRT-PCR; Western blot; TUNEL apoptosis assay PloS one High 23967200
2013 NFATc3 directly regulates MMP3 transcription in astrocytes in a calcium/calcineurin-dependent manner. Constitutively active NFATc3 induces Mmp3 expression; calcium ionophore and ATP stimulation increase Mmp3 mRNA and protein; calcineurin inhibitor cyclosporin A prevents this. An MMP3 promoter-luciferase reporter was activated by increased intracellular Ca2+. In vivo, MMP3 is expressed in NFATc3-positive scar-forming astrocytes after brain injury. Constitutively active NFATc3 overexpression; calcium ionophore treatment; MMP3 promoter-luciferase reporter assay; calcineurin inhibitor (CsA) treatment; in vivo stab-wound brain injury model; immunohistochemistry Glia High 23625833
2008 AMF/PGI transactivates the MMP-3 gene promoter through AP-1 via the Src-RhoA-PI3-kinase signaling pathway to induce hepatoma cell migration. The three signaling molecules Src, RhoA, and PI3-kinase form a complex, and MMP-3 induction correlates with AMF/PGI enzymatic activity. MMP-3 promoter-luciferase reporter assay; signaling pathway inhibitors; co-immunoprecipitation of Src-RhoA-PI3K complex; cell migration assay Cancer letters Medium 18571835
2008 Keratinocyte expression of MMP3 promotes cellular differentiation and impedes tumor establishment; MMP3-expressing papilloma cell lines lost capacity to form palpable tumors in vivo and showed increased differentiation in vitro; this differentiation effect was inhibited by broad-spectrum MMP inhibitors and selective MMP3 inhibition. Transgenic mice with keratinocyte-targeted MMP3; chemical carcinogenesis model; orthotopic injection of stable MMP3-expressing cell lines; in vitro differentiation assays with MMP3 inhibition The American journal of pathology High 18832569
2011 ERK1 and ERK2 each regulate IL-1β-induced MMP3 (and MMP13) expression in human chondrocytes; knockdown of either ERK1 or ERK2 alone significantly reduces IL-1β-induced MMP3 protein and mRNA, and combined knockdown has synergistic suppression. No compensatory upregulation of the opposing isoform occurs. Specific siRNA knockdown of ERK1, ERK2, or both; IL-1β stimulation; quantitative RT-PCR; ELISA; Western blot International journal of molecular medicine Medium 21305249
2011 Protein kinase D1 (PKD1) mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts. siRNA targeting PKD1 completely inhibited MMP-3 mRNA and protein expression; the signaling cascade involves PKC, PKD1, and MEK acting at the transcriptional level. PKD1 siRNA knockdown; PKC inhibitors (GF109203X, Go6983); MEK inhibitor (U0126); MMP-3 mRNA and protein quantification Biochemical and biophysical research communications Medium 21867693
2012 Substance P stimulates MMP3 expression and protein production in human tenocytes via the neurokinin-1 receptor (NK-1R). Gene expression analysis showed SP-induced increases in MMP3, COL3A1, and ACTA2 mRNA in 3D collagen lattices. Cyclic tensile loading together with SP had an additive effect on MMP3 expression. Immunoblotting confirmed NK-1R mediation of MMP3 protein upregulation. 3D collagen lattice culture; NK-1R-mediated signaling experiments; gene expression analysis; cyclic tensile loading; immunoblotting Journal of orthopaedic research Medium 22836729
2014 HOXA10 promotes MMP-3 expression and pancreatic cancer cell invasion via a TGFβ2-p38 MAPK pathway. Knockdown of HOXA10 decreases TGFβ2 and MMP-3 and suppresses p38 activation; TGFβ2 neutralization blocks HOXA10-driven MMP-3 induction; p38 inhibition suppresses MMP-3 expression and invasion. HOXA10 knockdown and overexpression; TGFβ2 neutralizing antibody; p38 inhibitor (SB239063); invasion and migration assays; Western blot Digestive diseases and sciences Medium 24464212
2016 MMP3 overexpression in preadipocytes (3T3-L1) inhibits adipogenic differentiation; recombinant human MMP3 added to primary human preadipocytes inhibits differentiation; recombinant TIMP4 rescues adipogenesis and attenuates MMP3's inhibitory effect. In male mice, high-fat diet-induced obesity increases MMP3 protein and enzymatic activity, whereas in females it decreases MMP3 protein. These data establish MMP3 as an antiadipogenic factor regulated sex-dependently. Mmp3 overexpression in 3T3-L1 preadipocytes; rhMMP3 and rhTIMP4 treatment of primary human preadipocytes; enzymatic activity assays; protein quantification; sex-stratified HFD mouse model American journal of physiology. Endocrinology and metabolism High 27879248
2017 BMAL1 deficiency enhances Mmp3 transcription through activating p65 (NF-κB) phosphorylation. Mmp3 KO mice show reduced mandibular hypoplasia, and MMP3 is elevated in BMAL1-deficient mice and juvenile patients with skeletal mandibular hypoplasia, establishing BMAL1 as a transcriptional repressor of MMP3 via NF-κB p65. BMAL1-deficient mice; RNA sequencing; protein chip analysis; Western blot for p65 phosphorylation; immunohistochemistry; human patient samples Stem cell reports Medium 29276151
2015 IRF8 directly transcriptionally represses MMP3, forming an inverse IRF8-MMP3 axis. Growth advantage from IRF8 loss is significantly compromised after MMP3 silencing. MMP3 loss reduces spontaneous lung metastasis in an orthotopic mouse mammary carcinoma model and acts in a cell-intrinsic manner. Gene expression profiling; IRF8 loss/gain experiments; MMP3 siRNA silencing in IRF8-deficient tumors; orthotopic mammary carcinoma mouse model; lung metastasis quantification Oncotarget Medium 26008967
2004 A bacterial ligand of integrin α5β1 (protein I/II from oral streptococci) induces upregulation of MMP-3 gene expression and increased pro-MMP-3 release in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs), but not in osteoarthritis FLSs, suggesting integrin α5β1-mediated MMP-3 induction contributes to RA joint destruction. Human cancer cDNA expression arrays; RT-PCR; pro-MMP-3 assay on conditioned media from RA FLSs treated with protein I/II Arthritis research & therapy Medium 15642131
2013 Eotaxin-1 (CCL11) induces MMP-3 mRNA expression and protein secretion in human chondrocytes through G protein-coupled receptor activities. ERK and p38 kinase inhibitors repress eotaxin-1-induced MMP-3 expression, while cAMP/PKA antagonism enhances it. MMP-3 protein secretion is regulated specifically by PLC-PKC cascade and JNK/MAPK pathways downstream of eotaxin-1 receptor. ERK, p38, PKA, PLC-PKC, and JNK pathway inhibitors; dose-response experiments; MMP-3 mRNA quantification; ELISA of secreted MMP-3; primary chondrocytes and SW1353 cell line Journal of biomedical science Medium 22114952
2014 MMP3 promoter polymorphisms (rs522616 and rs3025058) are functional: the rs522616 A allele binds a specific DNA-protein complex and shows greater promoter activity than the G allele, but the ultimate effect is regulated by the rs3025058 background allele. For TIMP2 rs8179096, the T allele shows ~2.5-fold increased promoter activity versus C, and both alleles bind NF-κB. Electrophoretic mobility shift assay (EMSA) for DNA-protein complex; promoter-luciferase reporter assays; allele-specific transfection experiments Journal of dental research Medium 24799419
2019 Notch3 (NICD3) expression in prostate cancer cells elevates MMP-3 secretion, and inhibition of MMP-3 rescues NICD3-induced osteoblastic bone lesion phenotypes. Active Notch3 reduces osteolytic lesion area and enhances osteoblastogenesis while inhibiting osteoclastogenesis, and this is mediated through MMP-3, defining a Notch3-MMP-3 axis in bone metastasis. Notch3 gain/loss-of-function in mouse tibia xenografts; MMP-3 inhibition rescue experiments; conditioned medium osteoblast/osteoclast differentiation assays; clinical osteoblastic metastasis samples Oncogene High 31467432
2020 MMP3 ablation in prostate cancer cells reduces in vitro cell growth with decreased AKT and ERK phosphorylation and lower VEGFR1 and FGFR3 protein levels. In vivo, MMP-3-ablated tumors grow slower and are less vascularized. MMP-3 in conditioned media supports endothelial tube formation, establishing intrinsic (growth signaling) and extrinsic (angiogenesis) roles for tumor-derived MMP-3. MMP-3 siRNA ablation; in vitro growth assay; AKT/ERK phosphorylation Western blot; in vivo tumor growth; endothelial tube formation assay; qPCR for angiogenic factors Neoplasia Medium 32896761
2020 MMP3 knockout (by CRISPR/Cas9) in tumor cells reduces tumoroid size, promotes necrosis within tumoroids, and causes additional release of broken EVs. MMP3-rich EVs from wild-type tumoroids can rescue MMP3-KO tumoroid growth, whereas MMP3-null EVs cannot, demonstrating that EV-mediated transfer of MMP3 protein promotes tumor cell proliferation and tumorigenesis. CRISPR/Cas9 MMP3 knockout; 3D tumoroid culture; EV isolation and characterization; fluorescent EV transfer assay; conditioned medium rescue experiments; Ki-67 proliferation marker Cancers High 32429403
2024 Loss of KMT2C or KMT2D (H3K4 methyltransferases) leads to epigenetic upregulation of MMP3 via enhanced KDM6A (H3K27me3 demethylase) binding at the Mmp3 locus, associated with altered H3K4me1, H3K27ac, and H3K27me3 marks. Pharmacological KDM6A inhibition or direct MMP3 downregulation prevents brain metastasis in TNBC models, establishing a KMT2C/D loss → KDM6A → MMP3 → brain metastasis axis. KMT2C/D knockout mouse models; global chromatin profiling (ChIP-seq for H3K4me1, H3K27ac, H3K27me3); KDM6A ChIP-seq; KDM6A pharmacological inhibition; Mmp3 siRNA knockdown; in vivo brain metastasis assays; human KMT2C-mutant TNBC samples Nature cell biology High 38926506
2023 IGF2BP3 binds and stabilizes MMP3 mRNA through interaction with N6-methyladenosine (m6A) modification, upregulating MMP3 protein expression. MMP3 acts downstream of IGF2BP3 to regulate cardiomyocyte proliferation and cardiac regeneration after myocardial infarction in mice. IGF2BP3 gain/loss-of-function in mice; m6A binding assay (MeRIP); mRNA stability experiments; cardiac injury model; cardiomyocyte proliferation assay; functional cardiac assays Cell death discovery High 37188676
2019 ERK1 (but not ERK2) phosphorylates ATF-2, which then directly contributes to IL-1β-induced MMP-3 mRNA expression in dermal fibroblasts. ERK inhibitor blocks both ATF-2 phosphorylation and MMP-3 induction; ERK1 siRNA reduces ATF-2 phosphorylation and MMP-3 expression, but ERK2 siRNA does not affect ATF-2 phosphorylation, defining an isoform-specific ERK1/ATF-2/MMP-3 axis. ERK1 and ERK2 specific siRNA knockdown; ERK inhibitor (FR180204); ATF-2 siRNA and inhibitor; phosphorylation Western blot; MMP-3 mRNA quantification PloS one Medium 31536594
2017 TWIST1 upregulates MMP3 expression in chondrocytes without directly binding the MMP3 promoter; instead, TWIST1 increases 5-hydroxymethylcytosine (5hmC) levels at the MMP3 promoter by inducing TET1 expression. TWIST1-dependent Mmp3 upregulation is suppressed in Tet triple KO fibroblasts, establishing a TWIST1→TET1→5hmC(MMP3 promoter)→MMP3 epigenetic regulatory axis. TWIST1 stable transfection; 5hmC chromatin analysis at MMP3 promoter; TET1/2/3 expression analysis; Tet triple KO fibroblasts from mouse ES cells; human OA and normal cartilage tissue comparison Scientific reports High 28220902
2022 Decidual macrophages are the predominant source of MMP3 in the first-trimester decidua. Decidual macrophage conditioned medium facilitates breakdown of laminin and fibronectin in a chorionic plate artery model of spiral artery remodeling, and this effect is abrogated by a MMP3 inhibitor, establishing MMP3 from decidual macrophages as a key mediator of extracellular matrix breakdown in spiral artery remodeling during early pregnancy. Decidual macrophage isolation and conditioned medium preparation; MMP membrane array; immunohistochemistry co-localization; chorionic plate artery ex vivo model; MMP3 inhibitor; fibronectin/laminin quantification (quickscore) Journal of reproductive immunology Medium 35176662
2024 MMP-3 mediates copper oxide nanoparticle (Nano-CuO)-induced pulmonary inflammation and fibrosis: Nano-CuO exposure induces MMP-3 overexpression and secretion in mouse lungs; MMP-3 knockdown significantly attenuates Nano-CuO-induced acute and chronic lung inflammation, injury, and fibrosis. MMP-3 also mediates Nano-CuO-induced cleavage of osteopontin (OPN), and MMP-3 knockdown reduces cleaved OPN levels. In vivo MMP-3 knockdown in mouse lungs; Nano-CuO exposure; bronchoalveolar lavage analysis; H&E and Trichrome staining; hydroxyproline content measurement; cleaved OPN assay Journal of nanobiotechnology Medium 39030581
2021 GBP5 promotes glioblastoma cell proliferation, migration, and invasion through the Src/ERK1/2/MMP3 signaling axis; GBP5 overexpression upregulates MMP3 and Src/ERK1/2 activation, while silencing GBP5 by RNA interference has opposite effects and impairs tumor growth in vivo. GBP5 overexpression and RNA interference; in vitro proliferation, migration, invasion assays; in vivo GBM tumor model; Src/ERK1/2/MMP3 pathway analysis by Western blot Cell death & disease Medium 33608513
2022 MMP3 knockout in mice significantly increases trabecular bone mass and trabecular number, and protects from ovariectomy-induced bone loss by inhibiting bone resorption rather than affecting bone formation. In humans, a MMP3 promoter polymorphism (rs632478) is associated with bone mineral density and affects promoter activity in transfection experiments. Mmp3 KO mice; ovariectomy model; micro-CT bone microarchitecture analysis; bone histomorphometry; promoter-luciferase reporter assay; human cohort analysis FASEB bioAdvances Medium 35949513

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 728 10428026
2005 Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Clinical & experimental metastasis 175 16158251
2012 MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3. Cancer letters 136 23142217
2008 Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia. Journal of neurochemistry 131 18419763
2008 Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene. British journal of sports medicine 119 19042922
2004 Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China. Carcinogenesis 96 15528217
2005 WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. Experimental cell research 95 15907837
2000 Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. Investigative ophthalmology & visual science 84 10670469
2016 NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis. Cancer research 83 27013197
1996 Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. British journal of cancer 81 8611434
2011 Effects and relationship of ERK1 and ERK2 in interleukin-1β-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes. International journal of molecular medicine 76 21305249
2009 Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford, England) 74 19056796
2016 High-fat diet-induced obesity regulates MMP3 to modulate depot- and sex-dependent adipose expansion in C57BL/6J mice. American journal of physiology. Endocrinology and metabolism 70 27879248
2017 Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma. Human molecular genetics 68 28158775
2014 Eotaxin-1 promotes prostate cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression. Oncology reports 65 24604010
2004 Positive selection on MMP3 regulation has shaped heart disease risk. Current biology : CB 63 15341739
2014 Expression and significance of MMP3 in synovium of knee joint at different stage in osteoarthritis patients. Asian Pacific journal of tropical medicine 61 24507680
2013 ERα signaling regulates MMP3 expression to induce FasL cleavage and osteoclast apoptosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 61 22927007
2016 Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis. IUBMB life 60 26873249
2014 Expression and regulation of MMP1, MMP3, and MMP9 in the chicken ovary in response to gonadotropins, sex hormones, and TGFB1. Biology of reproduction 59 24451989
2006 Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC cancer 59 17125518
2014 Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. Molecular cancer research : MCR 58 24850902
2007 Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study. Spine 56 18007247
2018 MiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3. International journal of biological sciences 55 29483840
2018 Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway. Anti-cancer drugs 55 29553945
2020 Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles. Cancers 51 32429403
2019 miR-134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo. FEBS letters 49 30977909
2003 NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 48 14519668
2011 Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. Molecular and cellular biochemistry 47 21667159
1990 Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22. Nucleic acids research 46 1975092
2019 Resveratrol Inhibits MMP3 and MMP9 Expression and Secretion by Suppressing TLR4/NF-κB/STAT3 Activation in Ox-LDL-Treated HUVECs. Oxidative medicine and cellular longevity 45 31583048
2012 MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression. Journal of clinical periodontology 43 22671570
2017 Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. PloS one 42 28961241
2011 Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis. Spine 42 21228692
2021 GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway. Cell death & disease 41 33608513
2019 Notch3 promotes prostate cancer-induced bone lesion development via MMP-3. Oncogene 41 31467432
2008 Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment. The American journal of pathology 41 18832569
2020 Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis. Neoplasia (New York, N.Y.) 40 32896761
2020 Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance. Signal transduction and targeted therapy 40 33243974
2024 Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3. Nature cell biology 38 38926506
2017 BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3. Stem cell reports 37 29276151
2014 HOXA10 promotes cell invasion and MMP-3 expression via TGFβ2-mediated activation of the p38 MAPK pathway in pancreatic cancer cells. Digestive diseases and sciences 37 24464212
2013 MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology. Glia 37 23404611
2012 Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium. Investigative ophthalmology & visual science 37 22222271
2012 Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 37 22836729
2009 Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. PloS one 35 19551141
2011 Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes. Journal of biomedical science 34 22114952
2004 Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma. Anticancer research 33 15274394
2020 The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3. Journal of orthopaedic surgery and research 32 32131874
2019 HTR1D, TIMP1, SERPINE1, MMP3 and CNR2 affect the survival of patients with colon adenocarcinoma. Oncology letters 32 31452735
2014 MMP3 and CXCL1 are potent stromal protein markers of dysplasia-carcinoma transition in sporadic colorectal cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 31 24999605
2017 Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes. BioMed research international 30 28265573
2016 MMP3 and TIMP2 gene variants as predisposing factors for Achilles tendon pathologies: Attempted replication study in a British case-control cohort. Meta gene 30 27222816
2015 Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K. European journal of pharmacology 30 25746423
2014 Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-κB pathway. Molecular medicine reports 30 24840287
2019 Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3. Journal of Cancer 28 31258780
2013 STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. PloS one 28 23967200
2004 MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin alpha5beta1. Arthritis research & therapy 28 15642131
2007 MMP gene polymorphisms as contributors for cleft lip/palate: association with MMP3 but not MMP1. Archives of oral biology 27 17537400
2011 Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts. Biochemical and biophysical research communications 26 21867693
2023 IGF2BP3 promotes adult myocardial regeneration by stabilizing MMP3 mRNA through interaction with m6A modification. Cell death discovery 25 37188676
2021 Exosomes miR-15a promotes nucleus pulposus-mesenchymal stem cells chondrogenic differentiation by targeting MMP-3. Cellular signalling 25 34252537
2016 Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts. PloS one 25 26829555
2013 NFATc3 promotes Ca(2+) -dependent MMP3 expression in astroglial cells. Glia 25 23625833
2008 AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration. Cancer letters 25 18571835
2025 MMP3 at the crossroads: Linking molecular pathways to disease diagnosis and therapy. Pharmacological research 24 40311957
2016 Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition. Molecular medicine reports 24 27108649
2013 NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression. Cancer science 24 24168165
2011 Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncology letters 23 22848309
2009 Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. Molecular vision 23 20038976
2020 17β-Estradiol Prevents Extracellular Matrix Degradation by Downregulating MMP3 Expression via PI3K/Akt/FOXO3 Pathway. Spine 22 31809475
2015 MMP3-mediated tumor progression is controlled transcriptionally by a novel IRF8-MMP3 interaction. Oncotarget 22 26008967
2014 PLGF inhibition impairs metastasis of larynx carcinoma through MMP3 downregulation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 22 24946722
2021 Targeting matrix metalloproteinase MMP3 greatly enhances oncolytic virus mediated tumor therapy. Translational oncology 21 34530193
2021 MiR-874-3p plays a protective role in intervertebral disc degeneration by suppressing MMP2 and MMP3. European journal of pharmacology 20 33482178
2019 Are MMP3, MMP8 and TIMP2 gene variants associated with anterior cruciate ligament rupture susceptibility? Journal of science and medicine in sport 20 30755371
2019 Cyclic tensile force-upregulated IL6 increases MMP3 expression by human periodontal ligament cells. Archives of oral biology 20 31377584
2017 TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes. Scientific reports 20 28220902
2015 Cyclosporine A Downregulates MMP-3 and MMP-13 Expression in Cultured Pterygium Fibroblasts. Cornea 20 26057330
2010 Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population. Diabetes research and clinical practice 20 20092902
2014 Functional Significance of MMP3 and TIMP2 Polymorphisms in Cleft Lip/Palate. Journal of dental research 19 24799419
2011 Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 19 21928379
2006 Evaluation of MMP3 and TIMP1 as candidate genes for high myopia in young Taiwanese men. American journal of ophthalmology 19 16935611
2020 In vivo delivery of MMP3-shRNA and Sox9 lentivirus cocktail enhances matrix synthesis to prevent lumbar disc degeneration. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 18 32589824
2019 ERK1/ATF-2 signaling axis contributes to interleukin-1β-induced MMP-3 expression in dermal fibroblasts. PloS one 18 31536594
2018 Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease markers 18 29670668
2018 IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3. Osteoarthritis and cartilage 18 30201492
2017 C/EBPβ Promotion of MMP3-Dependent Tumor Cell Invasion and Association with Metastasis in Colorectal Cancer. Genetic testing and molecular biomarkers 18 29172775
2023 Induction of MMP-3 and MMP-9 expression during Helicobacter pylori infection via MAPK signaling pathways. Helicobacter 17 37139985
2022 Decidual macrophage derived MMP3 contributes to extracellular matrix breakdown in spiral artery remodeling in early human pregnancy. Journal of reproductive immunology 17 35176662
2022 New insights into the role of matrix metalloproteinase 3 (MMP3) in bone. FASEB bioAdvances 17 35949513
2021 MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment. Lasers in medical science 17 33990899
2019 MiR-574-3p exerts as a tumor suppressor in ovarian cancer through inhibiting MMP3 expression. European review for medical and pharmacological sciences 17 31486483
2016 Association Between IL-6 and MMP3 Common Genetic Polymorphisms and Idiopathic Scoliosis in Bulgarian Patients: A Case-control Study. Spine 17 26656061
2023 METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3. Regenerative therapy 16 36793308
2013 Chitosan-plasmid DNA nanoparticles encoding small hairpin RNA targeting MMP-3 and -13 to inhibit the expression of dedifferentiation related genes in expanded chondrocytes. Journal of biomedical materials research. Part A 16 23520014
2007 Differential expression of the metalloproteinase MMP3 and the alpha5 integrin subunit in human myometrium at labour. Molecular human reproduction 16 17664256
2024 MMP-3 mediates copper oxide nanoparticle-induced pulmonary inflammation and fibrosis. Journal of nanobiotechnology 15 39030581
2022 Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis. Scientific reports 15 35842459
2021 LncRSPH9-4 Facilitates Meningitic Escherichia coli-Caused Blood-Brain Barrier Disruption via miR-17-5p/MMP3 Axis. International journal of molecular sciences 15 34198485

Missed literature

Know a paper Affinage missed for MMP3? Flag it for the maintainers and the community.

No submissions yet.