Affinage

NFATC3

Nuclear factor of activated T-cells, cytoplasmic 3 · UniProt Q12968

Length
1075 aa
Mass
115.6 kDa
Annotated
2026-06-10
100 papers in source corpus 51 papers cited in narrative 51 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NFATC3 is a calcium- and calcineurin-regulated transcription factor that converts intracellular Ca2+ signals into target-gene programs governing cardiovascular remodeling, vascular tone, immune signaling, and cell differentiation (PMID:8684469, PMID:12370307, PMID:15322114). In its resting state it is held in the cytoplasm by phosphorylation: casein kinase Iα directly binds and phosphorylates the regulatory A domain through a two-phase hierarchical mechanism in which a primed Ser177 nucleates phosphorylation of downstream serines, masking the nuclear localization signal (PMID:9630228, PMID:11781102), and JNK phosphorylates additional sites that drive nuclear exclusion (PMID:9374467). Calcium influx triggers physical association with the phosphatase calcineurin, which dephosphorylates NFATC3 and is co-transported with it into the nucleus where it counters a nuclear NFAT kinase to sustain nuclear residence (PMID:8684469). In the nucleus NFATC3 binds NFAT sites, frequently cooperating with AP-1 partners such as c-Jun, to activate transcription with a DNA-binding specificity distinct from other family members (PMID:7739550, PMID:7650004, PMID:33393109). Genetic deletion establishes NFATC3 as the obligatory calcineurin effector for pathological cardiac hypertrophy and for arterial smooth-muscle remodeling, where it suppresses K+ channel subunits (Kv1.5, Kv2.1, Kv4.2/4.3) and the BK channel β1 and α subunits to alter excitability and tone during hypertension and after myocardial infarction (PMID:12370307, PMID:15322114, PMID:15087419, PMID:17148444, PMID:18579799). It drives hypoxia-induced pulmonary arterial remodeling and directly transactivates target promoters including sGC-α1, COX-2, RANKL, and myocardin, and activates miRNA programs (miR-23a, miR-153-3p, miR-324-5p, miR-204) that tune hypertrophy, mitochondrial fission, and atherogenesis (PMID:17403661, PMID:19574461, PMID:20177053, PMID:19592461, PMID:34570211, PMID:24291639). In immunity NFATC3 binds IRF7 and type I interferon promoters to potentiate antiviral interferon production and controls chemokine output in macrophages and during pathogen infection (PMID:25225460, PMID:27697837, PMID:33520407, PMID:37523510). Its abundance and nuclear occupancy are further set by SUMOylation, by SENP3-mediated deSUMOylation that weakens GSK-3β-dependent phosphorylation under hypoxia, and by the E3 ligases CHIP and Trim39 that drive proteasomal turnover, with Trim39 acting preferentially on SUMOylated NFATC3 and being antagonized by Trim17 (PMID:35484132, PMID:30980393, PMID:35449213).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1995 Medium

    Establishing that NFATC3 is a genuine NFAT-family transcription factor required showing it binds NFAT DNA elements and activates transcription in a calcium-regulated manner, which it did with distinct site specificity and AP-1 cooperativity.

    Evidence EMSA, reporter assays, and calcium-dependent mobility shift in COS-7/transfected cells

    PMID:7650004 PMID:7739550

    Open questions at the time
    • Endogenous target genes not yet defined
    • Mechanism of calcium-dependent mass change inferred, not directly mapped to residues
  2. 1996 High

    The core activation switch was defined by demonstrating calcium-induced physical association with calcineurin and co-transport as a complex that maintains nuclear dephosphorylation against an opposing kinase.

    Evidence Co-immunoprecipitation, nuclear import assays, cyclosporin A/FK506 inhibition

    PMID:8684469

    Open questions at the time
    • Identity of the opposing nuclear kinase not resolved here
    • Binding interface not mapped
  3. 1997 High

    The kinase arm opposing activation was identified by showing JNK phosphorylates two sites whose mutation causes constitutive nuclear NFATC3, establishing JNK as an antagonist of calcineurin-driven import.

    Evidence In vitro kinase assay, phosphosite mutagenesis, nuclear localization readout

    PMID:9374467

    Open questions at the time
    • Upstream signals controlling JNK in physiological contexts not addressed
  4. 1998 High

    How phosphorylation masks the NLS was clarified by showing CKIα directly binds and phosphorylates NFATC3 to enforce cytoplasmic retention, with MEKK1 stabilizing this interaction.

    Evidence Co-IP, in vitro kinase assay, nuclear translocation and co-expression epistasis

    PMID:9630228

    Open questions at the time
    • Precise serines targeted by CKIα not yet enumerated at this stage
  5. 2002 High

    The biochemical logic of CKI control was resolved by defining a docking-and-priming hierarchical mechanism initiating at Ser177 and propagating to downstream serines.

    Evidence Systematic in vitro kinase assays on 27 peptide variants with phosphoserine/alanine mutagenesis and kinetic analysis

    PMID:11781102

    Open questions at the time
    • In vivo occupancy of each site under physiological signaling not quantified
  6. 2001 High

    Physiological relevance of the calcineurin/NFAT axis was established genetically by showing NFATC3/NFATC4 double knockouts die with vascular assembly defects phenocopied by a Ca2+-insensitive calcineurin mutation.

    Evidence Double knockout and calcineurin B point-mutant knockin mice, embryological analysis

    PMID:11439183

    Open questions at the time
    • NFATC3-specific versus redundant contribution within the double KO not separated
  7. 2002 Medium

    Cell-type-specific input requirements were defined by showing PDGF-induced nuclear import in smooth muscle needs Ca2+ entry through voltage-dependent channels plus PDGF-driven modulation, indicating Ca2+ alone is insufficient.

    Evidence GFP-NFAT4 imaging with Ca2+/K+ channel and calcineurin pharmacology

    PMID:11278965

    Open questions at the time
    • The additional PDGF-dependent step controlling import/export not molecularly identified
  8. 2002 High

    NFATC3 was shown to be the required calcineurin effector for pathological cardiac hypertrophy across multiple stimuli, distinguishing it from NFATC4.

    Evidence Knockout mice in calcineurin-transgene, pressure-overload, and angiotensin II hypertrophy models

    PMID:12370307

    Open questions at the time
    • Direct hypertrophic target genes not yet identified in this study
  9. 2008 High

    A coherent vascular program emerged from knockout studies showing NFATC3 mediates calcineurin-dependent suppression of Kv and BK channel subunits to control arterial and bladder smooth-muscle excitability and tone.

    Evidence NFATC3 knockout mice with patch-clamp electrophysiology, Western blot/RT-PCR, hypertension and contractility models

    PMID:15087419 PMID:15322114 PMID:16614306 PMID:17148444 PMID:18579799 PMID:18832165

    Open questions at the time
    • Whether channel suppression is via direct promoter binding or indirect intermediates not fully resolved for each target
  10. 2009 High

    The pulmonary remodeling branch was mechanized by showing NFATC3 is required for hypoxia-induced α-actin and sGC-α1 upregulation, with NFATC3 binding the sGC-α1 promoter, and later linked to ET-1/RhoA-ROK-supported nuclear transport.

    Evidence Knockout and NFAT-reporter mice, promoter reporter assays, pharmacology and GFP-NFATc3 imaging in PASMC

    PMID:17403661 PMID:19592461 PMID:21525433

    Open questions at the time
    • Direct NFAT occupancy of the α-actin promoter not shown
    • ROK/actin contribution to import is correlative
  11. 2010 Medium

    Direct transcriptional outputs in heart and other tissues were defined by ChIP/reporter evidence placing myocardin, COX-2, RANKL, and several miRNAs downstream of NFATC3.

    Evidence ChIP, promoter reporter assays, siRNA knockdown across cardiomyocyte, osteoblast, and T/endothelial systems

    PMID:19574461 PMID:20177053 PMID:21514407 PMID:21642596 PMID:24291639 PMID:26633713 PMID:31903137

    Open questions at the time
    • Most targets validated in single labs
    • Combinatorial cofactor requirements at each promoter not mapped
  12. 2012 Medium

    Isoform-specific kinetics were established by showing NFATC3 dephosphorylates and translocates rapidly upon mild Ca2+ signals, unlike NFATC4, with its serine-proline region controlling nuclear accumulation magnitude.

    Evidence GFP-NFAT chimera imaging, domain-swap constructs, siRNA, reporter assays in neurons; leptomycin B comparison in muscle fibers

    PMID:16436503 PMID:22977251

    Open questions at the time
    • Structural basis for the serine-proline region effect not solved
  13. 2014 High

    An immune signaling role was defined by showing pathogen GRA6/CAMLG selectively activates NFATC3 and that NFATC3 binds IRF7 and type I IFN promoters to potentiate interferon production.

    Evidence Knockout parasites and host mice, Co-IP, ChIP, promoter mutagenesis

    PMID:25225460 PMID:27697837 PMID:33520407

    Open questions at the time
    • Stoichiometry of the NFATC3-IRF7 complex on promoters not defined
  14. 2014 High

    Post-translational control of NFATC3 stability and nuclear occupancy was uncovered through SUMOylation-coupled ubiquitination: Trim17 and Trim39 act on SUMOylated NFATC3, CHIP drives proteasomal turnover, and SENP3 deSUMOylation reduces GSK-3β-dependent phosphorylation under hypoxia.

    Evidence Co-IP, in vitro ubiquitination, SUMO/SIM mutagenesis, SENP3 knockdown, ChIP and reporter assays

    PMID:25215946 PMID:30980393 PMID:35449213 PMID:35484132

    Open questions at the time
    • Some interactions (e.g., CHIP) rest on single Co-IP
    • Crosstalk between SUMO, ubiquitin and phosphorylation not integrated quantitatively
  15. 2017 Medium

    Developmental and oncogenic transcriptional targets were extended by ChIP-based identification of Etv2, OCT4, RAG1, and SRPX2 as NFATC3-regulated loci controlling hematopoietic commitment, stemness, DNA damage, and differentiation.

    Evidence ChIP, promoter reporters, genetic rescue, gain/loss-of-function in stem cells and cancer lines

    PMID:28419336 PMID:31040921 PMID:31822296 PMID:33393109

    Open questions at the time
    • Each target validated in a single cellular context
    • Direct repression versus activation mechanisms not uniformly defined
  16. 2016 High

    A scaffolded route for Ca2+ entry was defined by showing PICK1 couples ASIC1-mediated Ca2+ influx to calcineurin to drive NFATC3 nuclear import in pulmonary smooth muscle.

    Evidence ASIC1 knockout mice, PICK1 inhibition, proximity ligation assay, GFP-NFATc3 imaging

    PMID:27190058 PMID:31903118

    Open questions at the time
    • Whether PICK1-ASIC1-calcineurin coupling operates outside vascular/synovial contexts unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple post-translational inputs (CKIα/JNK/GSK-3β phosphorylation, SUMOylation, SENP3 deSUMOylation, CHIP/Trim39 ubiquitination) are integrated in real time to set NFATC3 nuclear occupancy and select among its many target programs remains unresolved.
  • No integrated kinetic model linking modifications to target-gene selection
  • No structural model of the calcineurin-NFATC3 or NFATC3-IRF7/c-Jun complexes
  • Tissue determinants of target-gene choice not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0003677 DNA binding 5
Localization
GO:0005634 nucleus 5 GO:0005829 cytosol 3
Pathway
R-HSA-168256 Immune System 5 R-HSA-162582 Signal Transduction 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-392499 Metabolism of proteins 3
Partners
CSNK1A1IRF7JNKJUNPICK1PPP3 (CALCINEURIN)TRIM17TRIM39

Evidence

Reading pass · 51 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 Calcium signaling induces a physical association between NF-AT4 (NFATC3) and calcineurin, and these molecules are transported as a complex to the nucleus, where calcineurin continues to dephosphorylate NF-AT4, counteracting a nuclear NF-AT kinase. Co-immunoprecipitation, nuclear import assays, pharmacological inhibition with cyclosporin A/FK506 Nature High 8684469
1997 JNK phosphorylates NFAT4 (NFATC3) on two sites; mutational removal of these JNK phosphorylation sites causes constitutive nuclear localization of NFAT4, while JNK activation in calcineurin-stimulated cells causes nuclear exclusion of NFAT4, showing JNK opposes calcineurin-driven nuclear accumulation. In vitro kinase assay, site-directed mutagenesis, nuclear localization assays Science High 9374467
1998 Casein kinase I alpha (CKIα) directly binds and phosphorylates NF-AT4 (NFATC3), establishing intramolecular masking of the nuclear localization signal to inhibit nuclear translocation; MEKK1 indirectly suppresses nuclear import by stabilizing the NF-AT4/CKIα interaction. Co-immunoprecipitation, in vitro kinase assay, nuclear translocation assays, epistasis by co-expression Cell High 9630228
1995 NFATc3 (NFATx) binds NFAT sites in the IL-2 promoter when combined with AP-1 (c-Fos/c-Jun) and activates IL-2 promoter transcription; it undergoes a calcium-dependent decrease in apparent molecular mass that is inhibited by FK506, consistent with calcineurin-dependent dephosphorylation. EMSA, reporter gene assay in COS-7 cells, Western blot mobility shift upon calcium elevation Molecular and cellular biology Medium 7739550
1995 NFATc3 activates NFAT-site-dependent transcription and exhibits a distinct DNA-binding site specificity compared to other NFATc family members, and undergoes calcium-dependent modifications blocked by FK506. Reporter gene assay, DNA-binding specificity assays, Western blot The Journal of biological chemistry Medium 7650004
2000 Calcineurin enzymatic activity is transiently increased during initiation of myogenic differentiation in C2C12 cells and is associated with NFATc3 nuclear translocation; adenoviral calcineurin enhances differentiation while calcineurin inhibitory peptides attenuate it; NFATc3 cotransfection enhances MyoD-directed myogenesis. Calcineurin enzymatic assay, adenoviral gene transfer, nuclear translocation assay, MyoD co-transfection Molecular and cellular biology High 10938134
2002 Targeted disruption of NFATc3 (but not NFATc4) significantly reduces calcineurin transgene-induced cardiac hypertrophy and attenuates pressure overload- and angiotensin II-induced cardiac hypertrophy, providing genetic evidence that calcineurin signaling requires NFATc3 as a downstream effector in vivo. Genetic knockout mice, cardiac hypertrophy models (calcineurin transgene, pressure overload, angiotensin II infusion), morphometric analysis Molecular and cellular biology High 12370307
2004 NFATc3 is an obligatory component of the calcineurin-dependent signaling cascade mediating angiotensin II-induced reduction of Kv2.1 K+ channel subunit expression and decreased Kv currents in arterial smooth muscle. NFATc3 knockout mice, electrophysiology (Kv current recordings), Western blot, pharmacological inhibition The Journal of biological chemistry High 15322114
2004 NFATc3 is required for post-myocardial infarction reductions in Kv currents (Ito, IKslow1, IKslow2) and Kv1.5, Kv2.1, Kv4.2, Kv4.3 expression; beta-adrenergic signaling activates calcineurin/NFATc3 to decrease these channels, and Kv currents do not change after MI in NFATc3 knockout mice. NFATc3 knockout mice, electrophysiology, Western blot, RT-PCR, calcineurin inhibitor (cyclosporine), beta-blocker treatment Circulation research High 15087419
2006 NFATc3 activation down-regulates the beta1 subunit of BK channels in arterial smooth muscle during angiotensin II-induced hypertension; beta1 expression was decreased in WT but not NFATc3-null arteries, and NFATc3-null mice showed attenuated angiotensin II-induced hypertension. NFATc3 knockout mice, patch-clamp electrophysiology, Western blot, angiotensin II infusion model The Journal of biological chemistry High 17148444
2006 Differential calcineurin/NFATc3 activity (higher in endocardial than epicardial myocytes) contributes to the transmural Ito gradient in the mouse left ventricle; NFATc3-null mice show complete loss of Ito and Kv4 heterogeneity. NFATc3 knockout mice, electrophysiology, NFAT reporter assay, Ca2+ imaging Circulation research High 16614306
2007 NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling; NFATc3 knockout mice do not show increased alpha-actin levels or increased arterial wall thickness after chronic hypoxia, establishing NFATc3 as required for hypoxia-induced vascular remodeling. NFATc3 knockout mice, NFAT-luciferase reporter mice, immunofluorescence, cyclosporin A pharmacology The Journal of biological chemistry High 17403661
2007 GSK-3β suppresses myogenic differentiation through negative regulation of NFATc3 nuclear translocation and transcriptional activity; NFATc3-deficient myoblasts fail to show increased muscle gene expression following GSK-3β inhibition, establishing NFATc3 as the required downstream effector. GSK-3β knockout/kinase-dead mutant reconstitution, NFATc3 knockout myoblasts, nuclear translocation assay, NFAT promoter reporter, muscle gene expression The Journal of biological chemistry High 17977834
2009 NFATc3 directly activates miR-23a expression through transcriptional machinery in cardiomyocytes undergoing hypertrophy; miR-23a in turn suppresses translation of MuRF1 (muscle specific ring finger protein 1), an anti-hypertrophic protein. Reporter gene assay (miR-23a promoter), ChIP, knockdown experiments, Western blot Proceedings of the National Academy of Sciences of the United States of America Medium 19574461
2010 NFATc3 binds to the promoter region of myocardin and transcriptionally activates its expression; knockdown of myocardin attenuates hypertrophic responses triggered by NFATc3, placing myocardin downstream of NFATc3 in the hypertrophic cascade. ChIP, promoter reporter assay, siRNA knockdown, Western blot The Journal of biological chemistry Medium 20177053
2001 Calcineurin/NFATc3 signaling is required for normal vasculogenesis; mice with disruption of both NFATc3 and NFATc4 die around E11 with generalized vascular assembly defects, and a Ca2+-insensitive calcineurin B mutation phenocopies these defects. Genetic double knockout mice, calcineurin B point mutation knockin, embryological analysis Cell High 11439183
2001 PDGF-induced NFAT4 (NFATC3) translocation in native smooth muscle requires Ca2+ entry through voltage-dependent Ca2+ channels; elevation of [Ca2+]i by membrane depolarization or ionomycin alone is insufficient for NFAT4 nuclear accumulation, indicating Ca2+ influx is necessary but not sufficient and PDGF-induced modulation of nuclear import/export is also required. GFP-NFAT4 nuclear translocation assay, Ca2+ channel blockers, K+ channel opener, calcineurin blockers (CsA, FK506), luciferase reporter The Journal of biological chemistry Medium 11278965
2002 NFAT4 (NFATC3) induces chondrogenesis and activates BMP2 gene expression; calcineurin/NFAT4 acts upstream of BMP signaling, since BMP antagonists block calcium/calcineurin-induced chondrogenesis. Calcium ionophore treatment, calcineurin inhibitor (cyclosporin A), dominant-negative BMP receptors, reporter gene assay, chondrogenic differentiation assays The Journal of biological chemistry Medium 12239209
2003 Physiological intravascular pressure (100 mmHg) induces NFATc3 nuclear localization in mouse cerebral artery smooth muscle via a pathway requiring endothelial NO, cGMP-dependent kinase (PKG), voltage-dependent Ca2+ channels, and PKG-dependent inhibition of JNK2; NFATc3 nuclear accumulation is absent in JNK2-null arteries when PKG is blocked. NFATc3 immunofluorescence in intact arteries, endothelial denudation, pharmacological inhibitors (NOS, PKG, VDCC, JNK), JNK2 knockout mice The Journal of biological chemistry High 14688253
2002 CK1 (protein kinase CK1) phosphorylates the A domain of NF-AT4 (NFATC3) via a two-phase hierarchical mechanism: an acidic linker region provides a docking site for CK1 and allows initial (unorthodox) phosphorylation of Ser177; once phosphorylated, Ser177 primes hierarchical phosphorylation of downstream serines (S180, S181, S184, S186). In vitro kinase assay with 27 peptide variants, site-directed mutagenesis (alanine and phosphoserine substitutions), Km/Vmax analysis Biochemistry High 11781102
2001 A calcineurin-binding motif in NFATx (NFATC3) identified; a competing peptide (Pep3) based on this motif selectively blocks nuclear translocation of NFATx but not NFATp, and suppresses cytokine production by T cells expressing NFATx. Peptide competition assay, retrovirus-mediated gene transfer, nuclear translocation assay, cytokine measurement Journal of immunology Medium 11509611
2008 PKCα-dependent persistent Ca2+ sparklets in arterial myocytes activate the calcineurin/NFATc3 signaling cascade, leading to increased Ca2+ entry, elevated arterial [Ca2+]i, and enhanced myogenic tone during hypertension; PKCα ablation is protective against angiotensin II-induced hypertension. Total internal reflection fluorescence microscopy (Ca2+ sparklet imaging), PKCα knockout mice, NFATc3 reporter assay Proceedings of the National Academy of Sciences of the United States of America High 18832165
2008 NFATc3 regulates BK channel alpha-subunit expression in urinary bladder smooth muscle; NFATc3-null mice show reduced BK currents, decreased BK alpha-subunit mRNA, and elevated contractile responses to electrical field stimulation. NFATc3 knockout mice, patch-clamp electrophysiology, RT-PCR, contractility assay American journal of physiology. Cell physiology High 18579799
2009 NFATc3 is required for chronic hypoxia-induced upregulation of soluble guanylyl cyclase alpha1 (sGC-α1) expression in pulmonary arterial smooth muscle; NFATc3 binds functional sites in the sGC-α1 promoter and activates its transcription. NFATc3 knockout mice, cyclosporin-treated mice, promoter reporter assay, NFAT binding site identification American journal of physiology. Lung cellular and molecular physiology Medium 19592461
2011 Endothelin-1 (ET-1) contributes to chronic hypoxia-induced NFATc3 activation in pulmonary arteries via RhoA/Rho kinase (ROK) and calcineurin; ROK increases actin polymerization to provide structural support for NFATc3 nuclear transport, downstream of Ca2+-calcineurin-dependent dephosphorylation. NFAT-luciferase reporter mice, pharmacological inhibitors (ET receptor, calcineurin, L-type Ca2+ channels, ROK), GFP-NFATc3 nuclear import assay in human PASMC American journal of physiology. Cell physiology Medium 21525433
2011 NFATc3 is specifically required for IL-2 and COX-2 gene expression in T cells and for T-cell proliferation; NFATc3 also regulates COX-2 in endothelial cells where it is required for COX-2-dependent migration and angiogenesis in vivo. siRNA knockdown, reporter gene assay, cell migration assay, in vivo angiogenesis assay Blood Medium 21642596
2011 NFATc3 directly binds to the RANKL promoter and stimulates RANKL expression in osteoblasts in response to high extracellular calcium; NFATc1 acts upstream by inducing NFATc3 expression and activity. ChIP, reporter assay, siRNA knockdown, overexpression Bone Medium 21514407
2012 In neurons, NFATc3 undergoes rapid dephosphorylation and nuclear translocation (complete within 20 min) upon Ca2+ elevation, while NFATc4 requires prolonged depolarization; the serine-proline repeat region of NFATc3 is critical for the magnitude of nuclear accumulation; knockdown of NFATc3 strongly diminishes NFAT-mediated transcription induced by mild depolarization. GFP-NFAT chimera nuclear translocation assay, NFATc3/c4 siRNA knockdown, phosphorylation immunoblot, luciferase reporter, domain-swap chimeras The Journal of biological chemistry Medium 22977251
2012 NFATc3 is expressed in pancreatic acinar cells and regulates trypsinogen activation and inflammatory cytokine (CXCL2) expression; NFATc3-deficient mice are protected from taurocholate- and L-arginine-induced acute pancreatitis. NFATc3 knockout mice, NFAT-luciferase reporter mice, NFAT inhibitor (A-285222), confocal immunofluorescence, trypsin activity assay Gastroenterology High 22841788
2013 NFATc3 binds to the RANTES promoter and directly regulates RANTES gene transcription in rheumatoid arthritis synovial fibroblasts in response to ASIC1a-mediated Ca2+ influx. ChIP-qPCR, dual-luciferase reporter assay, calcium imaging, ASIC1a overexpression/knockdown Theranostics Medium 31903118
2014 Trim17 binds preferentially SUMOylated forms of NFATc3 and reduces its calcium-mediated nuclear localization by approximately 2-fold without promoting its ubiquitination/degradation; NFATc3 induces transcription of the proapoptotic gene Trim17 via binding to its promoter together with c-Jun, creating a feedback loop. Co-immunoprecipitation, luciferase reporter, nuclear translocation assay, ChIP, siRNA knockdown, neuronal apoptosis assay Cell death and differentiation Medium 25215946
2014 T. gondii dense granule protein GRA6 selectively activates NFAT4 (NFATC3) via CAMLG (calcium modulating ligand); GRA6-deficient parasites fail to activate NFAT4, and NFAT4-deficient mice show decreased chemokine (Cxcl2, Ccl2) expression and altered immune cell recruitment at infection sites. GFP-NFAT4 reporter assay, GRA6 knockout parasites, NFAT4 knockout mice, overexpression, NFAT inhibitor treatment The Journal of experimental medicine High 25225460
2015 NFATc3 inhibits miR-324-5p expression; miR-324-5p suppresses translation of Mtfr1 (mitochondrial fission regulator 1); knockdown of NFATc3 suppresses mitochondrial fission, cardiomyocyte apoptosis and myocardial infarction. ChIP, luciferase reporter, siRNA knockdown, mitochondrial morphology imaging, apoptosis assays Cell death & disease Medium 26633713
2016 NFATC3 specifically binds to IRF7 protein and enhances IRF7-mediated type I IFN production; NFATC3 knockout greatly reduces CpG DNA-induced nuclear translocation of IRF7; both NFATC3 and IRF7 bind to type I IFN promoters and the NFAT binding site in IFN promoters is required for IRF7-mediated IFN expression. Co-immunoprecipitation, NFATC3 knockout (in vitro and in vivo), ChIP, reporter gene assay, NFAT binding site mutagenesis The Journal of experimental medicine High 27697837
2016 ASIC1-mediated Ca2+ influx promotes NFATc3 nuclear import in pulmonary arterial smooth muscle cells via a PICK1 scaffold protein that interacts with both ASIC1 and calcineurin; PICK1 inhibition abolishes NFATc3 nuclear import without altering Ca2+ responses. ASIC1 knockout mice, pharmacological ASIC1 inhibition, Duolink proximity ligation assay, PICK1 inhibitor, GFP-NFATc3 nuclear import assay American journal of physiology. Lung cellular and molecular physiology High 27190058
2017 NFATc3 directly targets the Etv2 promoter via an evolutionarily conserved cis-element to drive hematopoietic fate commitment in embryonic stem cells; constitutively active NFATc3 rescues Etv2 expression and hematopoietic progenitor formation in IP3R-triple-knockout cells. IP3R triple-knockout embryonic stem cells, constitutively active NFATc3 overexpression rescue, ChIP showing NFATc3 binding to Etv2 promoter, NFAT reporter assay Journal of molecular cell biology Medium 28419336
2019 NFATc3 is SUMOylated; hypoxia-induced SENP3-mediated deSUMOylation of NFATc3 at K384 impairs the interaction between NFATc3 and GSK-3β, decreases NFATc3 phosphorylation, and increases NFATc3 nuclear occupancy to promote pancreatic carcinoma progression. SUMOylation site mutation (K384), co-immunoprecipitation, SENP3 knockdown, nuclear fractionation, in vitro deSUMOylation Cell death & disease Medium 35484132
2019 CHIP (carboxyl-terminus of Hsc70-interacting protein, an E3 ubiquitin ligase) promotes proteasomal degradation of NFATc3; co-immunoprecipitation demonstrates physical interaction between CHIP and NFATc3, and CHIP overexpression reduces NFATc3 protein levels and attenuates hypertrophy and apoptosis. Co-immunoprecipitation, Western blot, proteasome inhibitor treatment, CHIP overexpression Journal of cellular physiology Medium 30980393
2020 NFATc3 transcriptionally upregulates miR-204 in macrophages; miR-204-5p suppresses SR-A expression via canonical 3'UTR targeting, while nuclear miR-204-3p inhibits CD36 transcription; this NFATc3/miR-204 axis prevents foam cell formation and atherosclerosis. Macrophage-specific NFATc3 knockout and transgenic mice, ChIP, miR-204 rescue experiments, luciferase reporter European heart journal High 34570211
2020 NFATc3 activates miR-153-3p expression in cardiomyocytes; ChIP-qPCR and luciferase reporter assay confirmed NFATc3 as upstream transcriptional regulator of miR-153-3p; miR-153-3p suppresses Mfn1 translation, promoting mitochondrial fission and hypertrophy. ChIP-qPCR, luciferase reporter assay, siRNA knockdown, mitochondrial morphology imaging Theranostics Medium 31903137
2021 NFATc3 binds to the promoters of IFNL1 and IFNB1 genes in hepatocytes to promote IFN production; RIG-I pathway activation increases NFATc3 nuclear localization, which further enhances RIG-I-mediated IFN responses (positive feedback). ChIP, reporter gene assay, gain- and loss-of-function experiments, nuclear localization assay Oncoimmunology Medium 33520407
2022 Trim39 is an E3 ubiquitin ligase for NFATc3 that acts preferentially on SUMOylated forms of NFATc3; Trim39 binds and ubiquitinates NFATc3 in vitro and in cells, reducing NFATc3 protein level and transcriptional activity; Trim17 inhibits Trim39-mediated ubiquitination of NFATc3 by reducing both Trim39 E3 activity and the NFATc3/Trim39 interaction. In vitro ubiquitination assay, co-immunoprecipitation, siRNA knockdown, luciferase reporter, SUMOylation site mutagenesis, SUMO-interacting motif mutagenesis Cell death and differentiation High 35449213
2013 NFATc3 promotes Ca2+-dependent MMP3 expression in astrocytes; constitutively active NFATc3 induces Mmp3 expression, and a Mmp3 promoter luciferase reporter is activated by increased [Ca2+]i via calcineurin/NFAT, while other MMPs are unaffected. Constitutively active NFATc3 overexpression, calcium ionophore, cyclosporin A inhibition, promoter reporter assay, in vivo stab-wound model Glia Medium 23625833
2013 NFATc3 binds to the -GGAAA- sequence in the COX-2 promoter and transcriptionally activates COX-2 expression in cardiomyocytes in response to endothelin-1, as demonstrated by ChIP and promoter reporter assay. ChIP, promoter reporter assay, NFATc3 knockdown, cyclosporin A Molecular and cellular endocrinology Medium 24291639
2014 Nuclear Raf-1 phosphorylated at Ser621 associates with NFATc3 near its cognate binding site in the CXCR5 promoter, driving transcriptional upregulation of CXCR5 during retinoic acid-induced differentiation of HL-60 leukemic cells. Co-immunoprecipitation, ChIP, pharmacological inhibition (PD98059), reporter assay The FEBS journal Medium 24330068
2021 NFATc3 regulates CXCL2 gene expression in macrophages (CXCL2 promoter-luciferase reporter activity is accentuated by co-transfection with NFATc3 expression vector); NFATc3-deficient macrophages fail to produce CCL2 and CXCL2 in response to IL-33 or conditioned medium from bleomycin-treated epithelial cells, and adoptive transfer of NFATc3+/+ macrophages restores susceptibility to pulmonary fibrosis in NFATc3+/- mice. Promoter-luciferase reporter assay, macrophage-specific conditional KO, adoptive transfer, in vitro cytokine stimulation Aging and disease Medium 37523510
2017 NFATc3 occupies the RAG1 promoter for transcriptional repression; NFATc3 knockdown increases RAG1 expression and double-strand DNA damage in gastric cancer cells, while NFATc3 overexpression blocks RAG1 expression and DNA damage induced by arsenic sulfide. ChIP-qPCR, RNA-seq, siRNA knockdown, lentiviral overexpression, Western blot Journal of experimental & clinical cancer research Medium 31822296
2019 NFATc3 binds to the OCT4 promoter and activates OCT4 transcription to promote cancer stem cell self-renewal in oral squamous cell carcinoma; inhibition of OCT4 abrogates the CSC phenotype driven by NFATc3. ChIP, promoter reporter assay, NFATc3 overexpression and knockdown, OCT4 rescue experiments, tumor sphere formation assay Oncotarget Medium 31040921
2017 NFATc3 promotes myocardin (and AQP2) promoter activity; NFATc3 knockout mice display symptoms of nephrogenic diabetes insipidus (polyuria, reduced AQP2 expression) and ILK-conditional-knockdown mice show reduced nuclear localization of NFATc3, linking ILK→GSK3β→NFATc3 to AQP2 transcription. NFATc3 knockout mice, ILK conditional knockdown, reporter gene assay, nuclear localization assay Biochimica et biophysica acta. Gene regulatory mechanisms Medium 28736155
2021 NFATc3 interacts with c-JUN and regulates the expression of SRPX2; SRPX2 knockdown diminishes the upregulation of lineage and EMT markers induced by co-overexpression of NFATc3 and c-JUN in human embryonic stem cells, placing SRPX2 downstream of the NFATc3/c-JUN complex. Co-immunoprecipitation (NFATc3/c-JUN), siRNA knockdown, overexpression, differentiation marker assays Journal of cellular physiology Medium 33393109
2006 Activity-independent nucleocytoplasmic shuttling of NFATc1 occurs in resting skeletal muscle fibers (leptomycin B causes nuclear accumulation); however, NFATc3 does NOT show similar shuttling in resting fibers — leptomycin B did not cause nuclear accumulation of NFATc3 in unstimulated fibers, demonstrating isoform-specific regulation. Live-cell imaging of GFP-NFAT isoforms in adult skeletal muscle fibers, leptomycin B treatment, electrical stimulation, calcineurin inhibition Molecular biology of the cell Medium 16436503

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 434 8684469
2001 Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 352 11439183
2009 miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America 303 19574461
1997 Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science (New York, N.Y.) 299 9374467
1998 Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 267 9630228
2000 A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Molecular and cellular biology 240 10938134
2002 Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Molecular and cellular biology 218 12370307
1998 The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity 210 9768749
1995 NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Molecular and cellular biology 208 7739550
1995 NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. The Journal of biological chemistry 161 7650004
2010 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. The Journal of biological chemistry 136 20177053
2003 NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circulation research 122 12750314
2005 NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. The Journal of experimental medicine 115 15657288
2001 NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells. Nature immunology 115 11740499
2008 The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proceedings of the National Academy of Sciences of the United States of America 105 18832165
2006 Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension. The Journal of biological chemistry 103 17148444
2001 NFAT4 movement in native smooth muscle. A role for differential Ca(2+) signaling. The Journal of biological chemistry 100 11278965
2021 Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms. European heart journal 96 34570211
2014 Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6. The Journal of experimental medicine 93 25225460
2007 NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation. The Journal of biological chemistry 93 17403661
2004 NFATc3 regulates Kv2.1 expression in arterial smooth muscle. The Journal of biological chemistry 93 15322114
2004 NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction. Circulation research 90 15087419
2002 Calcineurin and NFAT4 induce chondrogenesis. The Journal of biological chemistry 88 12239209
2006 Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart. Circulation research 66 16614306
2020 ASIC1a induces synovial inflammation via the Ca2+/NFATc3/ RANTES pathway. Theranostics 61 31903118
2011 Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. International journal of biological sciences 58 21494433
2007 Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3. The Journal of biological chemistry 58 17977834
2015 NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1. Cell death & disease 53 26633713
2012 NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice. Gastroenterology 52 22841788
2013 miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer. Carcinogenesis 51 23929433
2011 NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis. Blood 47 21642596
2003 Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase. The Journal of biological chemistry 46 14688253
2007 Selective role of NFATc3 in positive selection of thymocytes. Journal of immunology (Baltimore, Md. : 1950) 45 17579027
2020 NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression. Theranostics 44 31903137
2010 Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: identification of a subpopulation of reactive astrocytes. Glia 43 20967884
2018 Long noncoding RNA n339260 promotes vasculogenic mimicry and cancer stem cell development in hepatocellular carcinoma. Cancer science 41 30022558
2006 NFAT4 is required for JC virus infection of glial cells. Journal of virology 40 17035332
2005 A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Blood 40 16051745
2006 Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Molecular biology of the cell 38 16436503
2014 Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca²⁺-mediated calcineurin/NFATc3 and CaMKII signaling cascades. Environmental toxicology and pharmacology 37 24975447
2012 Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. The Journal of biological chemistry 37 22977251
2004 The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4. The Journal of biological chemistry 37 15016802
2011 Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. American journal of physiology. Cell physiology 36 21525433
2019 Transient receptor potential vanilloid 4 is a critical mediator in LPS mediated inflammation by mediating calcineurin/NFATc3 signaling. Biochemical and biophysical research communications 35 31005256
2008 NFATc3-dependent loss of I(to) gradient across the left ventricular wall during chronic beta adrenergic stimulation. Journal of molecular and cellular cardiology 35 19027024
2013 Intermittent hypoxia-induced increases in reactive oxygen species activate NFATc3 increasing endothelin-1 vasoconstrictor reactivity. Vascular pharmacology 33 24239798
2011 High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-κB ligand in osteoblasts. Bone 33 21514407
2018 Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats. Journal of cellular and molecular medicine 32 30299584
2009 Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. American journal of physiology. Lung cellular and molecular physiology 32 19592461
2001 Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurin. Journal of immunology (Baltimore, Md. : 1950) 32 11509611
2015 MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3. International journal of molecular sciences 31 26473838
2020 Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway. Cardiovascular toxicology 29 31571030
2007 Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels. American journal of physiology. Cell physiology 29 17881610
2014 Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17. Cell death and differentiation 28 25215946
2012 Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element. Virology 28 22749879
2012 Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals. Biochemical and biophysical research communications 28 22846573
2003 Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950) 28 12626567
2010 NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. American journal of physiology. Heart and circulatory physiology 27 20495147
2013 NFATc3 promotes Ca(2+) -dependent MMP3 expression in astroglial cells. Glia 25 23625833
2021 Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression. The Tohoku journal of experimental medicine 24 33840648
2019 NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells. Scientific reports 24 31249342
2014 Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation. The FEBS journal 24 24330068
2013 COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3. Molecular and cellular endocrinology 24 24291639
2008 NFATc3 regulates BK channel function in murine urinary bladder smooth muscle. American journal of physiology. Cell physiology 24 18579799
2020 circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression. Journal of cellular physiology 23 32667692
2019 LncRNA NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation. Molecular and cellular biochemistry 23 30895498
2016 NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells. The Journal of experimental medicine 23 27697837
2012 Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochemical and biophysical research communications 23 23206701
2023 NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophages. Aging and disease 22 37523510
2020 The protective effect of Hederagenin on pulmonary fibrosis by regulating the Ras/JNK/NFAT4 axis in rats. Bioscience, biotechnology, and biochemistry 22 32024440
2016 ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology 22 27190058
2021 MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3. Molecular medicine reports 21 33495839
2017 NFATc3 mediates the sensitivity of gastric cancer cells to arsenic sulfide. Oncotarget 21 28881766
2010 Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. Molecular neurobiology 21 20369390
2019 NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4. Oncotarget 20 31040921
2018 NFATc3 deficiency reduces the classical activation of adipose tissue macrophages. Journal of molecular endocrinology 20 30307161
2017 IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. Journal of molecular cell biology 20 28419336
2022 Exosomes derived from bone marrow mesenchymal stem cells inhibit human aortic vascular smooth muscle cells calcification via the miR-15a/15b/16/NFATc3/OCN axis. Biochemical and biophysical research communications 19 36257194
2021 NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. Oncoimmunology 19 33520407
2002 Structural features underlying the multisite phosphorylation of the A domain of the NF-AT4 transcription factor by protein kinase CK1. Biochemistry 19 11781102
2022 TARBP2-stablized SNHG7 regulates blood-brain barrier permeability by acting as a competing endogenous RNA to miR-17-5p/NFATC3 in Aβ-microenvironment. Cell death & disease 18 35562351
2021 Betulinic Acid Improves Cardiac-Renal Dysfunction Caused by Hypertrophy through Calcineurin-NFATc3 Signaling. Nutrients 17 34684485
2019 CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation. Journal of cellular physiology 17 30980393
2018 NFATC3-PLA2G15 Fusion Transcript Identified by RNA Sequencing Promotes Tumor Invasion and Proliferation in Colorectal Cancer Cell Lines. Cancer research and treatment 17 29909608
2022 Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression. Cell death & disease 16 35484132
2020 Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3. Phytomedicine : international journal of phytotherapy and phytopharmacology 16 33002827
2017 NFATc3 and VIP in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease. PloS one 16 28125639
2003 NFAT4 is expressed in primary astrocytes and activated by glutamate. Journal of neuroscience research 16 12671993
2002 Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region. Journal of immunology (Baltimore, Md. : 1950) 15 11907091
2002 A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells. The Journal of biological chemistry 14 11997392
2022 Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway. European journal of pharmacology 13 36087696
2019 Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells. Journal of experimental & clinical cancer research : CR 13 31822296
2022 Trim39 regulates neuronal apoptosis by acting as a SUMO-targeted E3 ubiquitin-ligase for the transcription factor NFATc3. Cell death and differentiation 12 35449213
2021 miR-145-5p targets paxillin to attenuate angiotensin II-induced pathological cardiac hypertrophy via downregulation of Rac 1, pJNK, p-c-Jun, NFATc3, ANP and by Sirt-1 upregulation. Molecular and cellular biochemistry 12 33886061
2019 Fas/FasL-mediated cell death in rat's diabetic hearts involves activation of calcineurin/NFAT4 and is potentiated by a high-fat diet rich in corn oil. The Journal of nutritional biochemistry 12 31030170
2018 Fasudil improves endothelial dysfunction in rats exposed to chronic intermittent hypoxia through RhoA/ROCK/NFATc3 pathway. PloS one 12 29641598
2017 Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochimica et biophysica acta. Gene regulatory mechanisms 11 28736155
2014 Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation. BMC cardiovascular disorders 11 25422138
2008 NFAT4 deficiency results in incomplete liver regeneration following partial hepatectomy. The Journal of surgical research 11 19059606
2021 Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation. Journal of cellular physiology 10 33393109

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