Affinage

MMP15

Matrix metalloproteinase-15 · UniProt P51511

Length
669 aa
Mass
75.8 kDa
Annotated
2026-04-28
44 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP15 (MT2-MMP) is a cell-surface transmembrane metalloproteinase that activates pro-MMP-2 through a TIMP-2-independent mechanism requiring MMP-2 hemopexin C-domain association and contributions from both its own catalytic and hemopexin C domains (PMID:7559440, PMID:11584019, PMID:16825197). At the apical surface of polarized epithelia, MMP15 interacts with ZO-1 via its cytosolic tail and proteolytically cleaves E-cadherin, disrupting cell-cell junctions to drive epithelial-to-mesenchymal transition, cell extrusion, and Src-dependent proliferation (PMID:27374080, PMID:29061881). MMP15 cooperates with MT1-MMP downstream of Snai1 to degrade basement membranes during cancer cell intravasation and angiogenesis, and releases collagen IV NC1 domains during branching morphogenesis to activate β1-integrin/PI3K-AKT proliferative signaling (PMID:19915148, PMID:19853562). Its transcription is directly regulated by HIF-1α, NF-κB/TCF-4, and Snai1, while its mRNA stability is controlled by Alkbh3-mediated m1A demethylation, and its expression confers resistance to Fas- and TRAIL-induced apoptosis (PMID:21751260, PMID:27046058, PMID:21920357, PMID:39004750, PMID:16093241).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1995 High

    Identification of MMP15 as a new membrane-anchored MMP that activates pro-MMP-2 at the cell surface established it as the second member of the MT-MMP subfamily with defined substrate specificity.

    Evidence cDNA cloning from human placenta, gelatin zymography, and cell-surface localization in transfected cells

    PMID:7559440

    Open questions at the time
    • Mechanism of pro-MMP-2 intermediate processing steps not resolved
    • Whether TIMP-2 is required (as for MT1-MMP) was unknown
    • In vivo substrates beyond MMP-2 uncharacterized
  2. 2001 High

    Demonstration that MT2-MMP activates MMP-2 independently of TIMP-2 — unlike MT1-MMP — revealed a fundamentally distinct activation mechanism requiring MMP-2 hemopexin C-domain engagement.

    Evidence Reconstitution of MMP-2 activation in Timp2−/− cells; hemopexin C-domain blocking experiments

    PMID:11584019

    Open questions at the time
    • Which structural features of the MT2-MMP catalytic domain confer TIMP-2 independence was unresolved
    • Stoichiometry and structural basis of the MT2-MMP–MMP-2 complex unknown
  3. 2006 High

    Domain-swap chimeras between MT2-MMP and MT1-MMP mapped TIMP-2 independence to contributions from both the catalytic domain (first cleavage) and hemopexin C domain (second cleavage), resolving the structural basis of the distinct activation mechanism.

    Evidence Chimeric MT2-MMP/MT1-MMP constructs in Timp2−/− cells with MMP-2 activation assays and collagen gel cultures

    PMID:16825197

    Open questions at the time
    • Atomic-resolution structural model of MT2-MMP–MMP-2 interaction unavailable
    • Collagenase activity toward native collagen not fully characterized
  4. 2005 Medium

    Discovery that MMP15 confers resistance to death-receptor-mediated and serum-starvation-induced apoptosis expanded its role beyond ECM proteolysis to cell survival signaling.

    Evidence siRNA knockdown and ectopic overexpression in cancer cells with Fas, TRAIL, and serum starvation apoptosis assays

    PMID:16093241

    Open questions at the time
    • Whether anti-apoptotic effect requires catalytic activity or a non-proteolytic function is unknown
    • Downstream signaling intermediates linking MMP15 to apoptosis pathways not identified
    • Single-lab finding without independent replication
  5. 2009 High

    Parallel studies established MMP15 as an essential effector of Snai1-driven basement membrane invasion and angiogenesis in vivo, and as a protease releasing collagen IV NC1 domains to activate β1-integrin/PI3K-AKT signaling during branching morphogenesis, linking its proteolytic activity to both cancer progression and developmental patterning.

    Evidence siRNA silencing in cancer cells with in vivo BM invasion/intravasation assays; siRNA in submandibular gland organ culture with NC1 rescue and PI3K-AKT pathway analysis

    PMID:19853562 PMID:19915148

    Open questions at the time
    • Whether MT2-MMP directly cleaves collagen IV or acts indirectly through MMP-2 at the BM not definitively resolved
    • Relative contributions of MT1-MMP versus MT2-MMP in different tissue contexts not quantified
  6. 2011 Medium

    Identification of HIF-1α binding to the MT2-MMP promoter and Snai1-dependent transcription in endocardial cushion EMT established two key transcriptional regulators, connecting MMP15 expression to hypoxia and developmental EMT programs.

    Evidence ChIP of HIF-1α on MT2-MMP promoter in cancer cells; Snai1 overexpression/knockdown in mouse AV canal explants with MMP15 rescue

    PMID:21751260 PMID:21920357

    Open questions at the time
    • Whether HIF-1α and Snai1 cooperate or act independently on MMP15 transcription not tested
    • HIF-1α ChIP from single lab without independent confirmation
  7. 2016 High

    Three advances defined MMP15's substrate repertoire and transcriptional control: E-cadherin was identified as a direct proteolytic substrate requiring catalytic activity (E260A mutant negative), NF-κB/TCF-4 was shown to co-activate MMP15 transcription, and Mmp15-knockout mice revealed a role in mammary adipocyte fate determination.

    Evidence Active-site mutagenesis with E-cadherin cleavage product IP; ChIP of TCF-4/p65 on MMP15 promoter with rescue; global Mmp15−/− mice with mammary gland phenotyping

    PMID:27046058 PMID:27374080 PMID:27633994

    Open questions at the time
    • E-cadherin cleavage site not mapped at the amino acid level
    • Mechanism linking MMP15 to brown fat specification remains unresolved
    • Whether TCF-4/NF-κB regulation is tissue-specific not determined
  8. 2017 High

    Discovery that MT2-MMP localizes apically via ZO-1 interaction and cleaves E-cadherin to control cortical tension, cell extrusion, and Src-dependent proliferation established a non-canonical epithelial homeostasis function at adherens junctions.

    Evidence Reciprocal co-IP/MS for ZO-1 interaction; live imaging in polarized cells, 3D cysts, mouse organoids, and intestinal crypts in vivo

    PMID:29061881

    Open questions at the time
    • ZO-1 binding domain on MT2-MMP cytosolic tail not mapped
    • Whether apical sorting depends on ZO-1 or occurs independently is unresolved
    • Role of MT2-MMP in intestinal pathology (inflammation, tumorigenesis) not tested
  9. 2024 Medium

    Identification of Alkbh3-mediated m1A demethylation of Mmp15 mRNA as a mechanism controlling its stability and translation during neurogenesis introduced an epitranscriptomic layer of MMP15 regulation.

    Evidence Alkbh3 depletion/overexpression in neural stem cells; m1A mapping; mRNA stability assays; in vivo hippocampal neurogenesis and spatial memory assessment

    PMID:39004750

    Open questions at the time
    • Specific m1A site(s) on Mmp15 mRNA not mapped
    • Whether epitranscriptomic regulation of MMP15 operates in non-neural tissues is unknown
    • Single-lab finding

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of MT2-MMP's TIMP-2-independent MMP-2 activation, the identity of the E-cadherin cleavage site, the mechanism linking MMP15 to apoptosis resistance, and its relationship to adipocyte fate specification remain unresolved.
  • No crystal or cryo-EM structure of MT2-MMP or MT2-MMP–MMP-2 complex
  • E-cadherin cleavage site not mapped at residue level
  • Anti-apoptotic mechanism (catalytic vs. non-catalytic) undetermined
  • Downstream effectors in brown fat specification unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6 GO:0016787 hydrolase activity 3
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-1500931 Cell-Cell communication 2 R-HSA-162582 Signal Transduction 2
Partners
CDH1MMP14MMP2SNAI1ZO-1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 MMP15 (MT2-MMP) was identified as a membrane-type MMP with a transmembrane domain at the C terminus; it localizes to the cell surface and activates pro-gelatinase A (pro-MMP-2), processing the 68-kDa form through a 64-kDa intermediate to a 62-kDa active form upon transfection into cells. cDNA cloning from human placenta library, monoclonal antibody recognition of 64-kDa product in transfected cells, gelatin zymography, TIMP-1 fusion localization experiment The Journal of biological chemistry High 7559440
2001 MT2-MMP activates MMP-2 via a TIMP-2-independent pathway; activation requires MMP-2 hemopexin C-domain-dependent cell surface association of MMP-2 with MT2-MMP, and proceeds through the 68-kDa intermediate without requiring TIMP-2 or concanavalin A. Stable transfection of hMT2-MMP into TIMP-2-knockout (Timp2-/-) mouse cells; exogenous MMP-2 activation assays; hemopexin C-domain blocking experiments; TIMP binding kinetics (kon measurements); gelatin zymography The Journal of biological chemistry High 11584019
2006 The TIMP-2-independence of MT2-MMP-mediated MMP-2 activation is determined by contributions of both the MT2-MMP catalytic domain (higher propensity to initiate prodomain cleavage without TIMP-2) and the hemopexin C domain (required for the second activation cleavage); MT2-MMP also exhibits weak collagenase activity, and activation is enhanced in type I collagen gels. Chimeric MT2-MMP/MT1-MMP domain swap constructs expressed in Timp2-/- cells; MMP-2 activation assays; type I collagen gel cultures; TIMP-2/TIMP-3 inhibition assays; trimolecular complex analysis The Journal of biological chemistry High 16825197
2009 MT2-MMP (MMP15) cooperates with MT1-MMP downstream of Snail1 to drive basement membrane degradation, angiogenesis, and cancer cell intravasation in vivo; siRNA silencing of MT2-MMP completely ablates Snail1-triggered BM invasion and angiogenesis, and these activities cannot be mimicked by secreted MMPs. siRNA-specific silencing of MT1-MMP and MT2-MMP in cancer cells; in vivo BM invasion, angiogenesis, and intravasation assays; ectopic expression of MT1-MMP and MT2-MMP vs. secreted MMPs Proceedings of the National Academy of Sciences of the United States of America High 19915148
2009 Epithelial MT2-MMP proteolytically releases collagen IV NC1 domains during submandibular gland branching morphogenesis; NC1 domain release signals via β1 integrin and PI3K-AKT to promote proliferation and morphogenesis, linking MT2-MMP proteolysis to a downstream proliferative signaling cascade. MT2-MMP siRNA knockdown in submandibular gland organ culture; rescue with recombinant NC1 domains; β1 integrin and PI3K-AKT pathway analysis; HBEGF rescue experiments; proliferation and morphogenesis quantification Developmental cell High 19853562
2005 MMP15 functions as an anti-apoptotic factor in cancer cells; siRNA-mediated knockdown of MMP15 increases sensitivity to Fas-, TRAIL-, and serum starvation-induced apoptosis, while ectopic overexpression confers apoptosis resistance in HeLa S3 and other cancer cell lines. In vitro apoptosis resistance selection; siRNA knockdown; ectopic overexpression; gene expression profiling; apoptosis assays (Fas, TRAIL, serum starvation) The Journal of biological chemistry Medium 16093241
2011 MMP15 (mmp15) is a direct transcriptional target of Snai1 during endothelial-to-mesenchymal transformation (EMT) in endocardial cushion development; Snai1 overexpression induces mmp15 expression and mesenchymal cell migration, while catalytically active MMP15 promotes cell motility (but not transformation), and MMP15 activity rescues migration defects caused by Snai1 knockdown. Snai1 knockdown in mice (hypocellular endocardial cushions); Snai1 overexpression in AV canal collagen I gel explants; catalytically active MMP15 treatment; MMP inhibitor experiments; rescue experiments Developmental biology Medium 21920357
2016 MT2-MMP (MMP15) proteolytically cleaves E-cadherin, generating an 80-kDa N-terminal ectodomain fragment, leading to EMT; catalytically inactive E260A mutant MT2-MMP fails to produce E-cadherin cleavage, restore mesenchymal morphology, or enhance invasion, demonstrating that proteolytic activity is required. Lentiviral stable transfection of WT and E260A catalytic mutant MT2-MMP; immunoprecipitation of E-cadherin fragments from conditioned medium; MMP inhibitor (GM6001) treatment; siRNA knockdown of endogenous MT2-MMP; chick embryo CAM invasion assay Oncotarget High 27374080
2017 MT2-MMP (MMP15) localizes to the apical domain of polarized epithelial cells where its cytosolic tail interacts with ZO-1; it cleaves E-cadherin at apical junctions, disrupting E-cadherin-mediated cell quiescence, relaxing cortical tension, promoting cell extrusion, and re-sorting Src kinase activity to junctional complexes to drive proliferation. Co-immunoprecipitation and mass spectrometry (MT2-MMP cytosolic tail–ZO-1 interaction); live imaging/fractionation for apical localization; MT2-MMP loss-of-function in 2D polarized cells, 3D cysts, mouse colonic organoids ex vivo, and intestinal crypts in vivo; Src kinase activity assays Journal of cell science High 29061881
2016 MMP15 expression in mammary gland controls adipocyte fate determination; Mmp15-/- mice retain ductal branching morphogenesis but show differential impairment of thermogenic brown fat formation, while MMP14 controls white fat depot generation. Global Mmp15 knockout mice; mammary gland morphology assessment; transcriptome profiling of developing mammary glands Development (Cambridge, England) Medium 27633994
2011 MT2-MMP (MMP15) is a novel hypoxia-responsive gene; HIF-1α directly binds to a specific hypoxia-responsive element (HRE1) in the MT2-MMP promoter to transcriptionally upregulate MT2-MMP under hypoxia, conferring resistance to apoptosis and increased invasiveness. HRE binding/competition assays; chromatin immunoprecipitation (ChIP) with HIF-1α antibody on MT2-MMP promoter; promoter reporter assays; hypoxia treatment of multiple cancer cell lines; siRNA/OE functional assays Molecular carcinogenesis Medium 21751260
2019 HBXIP activates MMP15 expression through association with the proto-oncogene c-Myc; depletion of c-Myc abolishes HBXIP-mediated MMP-15 upregulation, and MMP15 mediates HBXIP-driven hepatocellular carcinoma cell migration and invasion. Luciferase reporter assays; chromatin immunoprecipitation (ChIP); siRNA knockdown; in vitro migration/invasion assays; in vivo metastasis model Cancer management and research Medium 31191014
2012 MMP-15 co-localizes with endoglin on the syncytiotrophoblast surface but does not cleave endoglin to produce soluble endoglin; concurrent siRNA knockdown of both MMP-14 and MMP-15 yields no further decrease in soluble endoglin compared to MMP-14 knockdown alone. siRNA knockdown of MMP-15 alone and combined with MMP-14 in HUVECs and BeWo cells; soluble endoglin quantification in conditioned medium; immunolocalization of MMP-15 on syncytiotrophoblast PloS one Medium 22768148
2012 MMP-15 is required for invasion of adipose-derived stromal cells (ASCs) through extracellular matrix; siRNA silencing of MMP-15 in obese-donor subcutaneous ASCs significantly reduces invasion through Matrigel and collagen-rich chick chorioallantoic membrane. siRNA knockdown of MMP-15; Matrigel invasion assay; chick CAM invasion assay; mRNA and protein expression analysis Stem cells (Dayton, Ohio) Medium 22969001
2024 The m1A demethylase Alkbh3 demethylates Mmp15 mRNA, improving its RNA stability and translational efficiency, which promotes neuronal differentiation and proliferation; Alkbh3 depletion in neural stem cells decreases Mmp15 expression, reducing neurogenesis. Alkbh3 depletion and overexpression in neural stem cells; m1A modification mapping; Mmp15 mRNA stability and translation assays; in vivo hippocampal neurogenesis and spatial memory assessment Cell & bioscience Medium 39004750
2016 TCF-4 functions as a co-activator of NF-κB p65 to promote MMP-15 transcription; TCF-4 potentiates p65 binding to a NF-κB element at -2833/-2824 in the MMP-15 promoter, and MMP-15 overexpression rescues migration defects caused by TCF-4 silencing. Reporter gene assay; ChIP assay; immunoblotting; siRNA knockdown with rescue by MMP-15 overexpression; xenograft model Scientific reports Medium 27046058
2019 LINC00482 promotes MMP15 expression by recruiting the transcription factor FOXA1 to the MMP15 promoter (dual-luciferase reporter assay); MMP15 in turn mediates LINC00482-driven tumor-associated inflammation and angiogenesis (VEGF, NF-κB), and MMP15 overexpression reverses the anti-tumor effects of LINC00482 silencing in vivo. Dual-luciferase reporter assay; gain- and loss-of-function in bladder cancer cells; in vivo tumor model; VEGF and NF-κB protein quantification Aging Low 33323547
1997 Mouse MT2-MMP (ortholog of human MMP15) activates progelatinase A upon co-transfection into COS-1 cells, confirming conserved MMP-2 activation function of this membrane-type MMP. cDNA cloning from mouse lung library; co-transfection into COS-1 cells; monoclonal antibody recognition of 70 kDa protein; sequence homology analysis FEBS letters Medium 9037199
2019 In medaka (teleost ortholog relevant to vertebrate ovulation), Mmp15 expression is regulated by CDK9-dependent phosphorylation of the nuclear progestin receptor (Pgr); phosphorylated Pgr binds the mmp15 promoter to drive LH-induced mmp15 transcription required for follicle rupture and ovulation. CDK9 inhibitor (CDK9-inhibitor II) and roscovitine treatment of medaka follicles; Pgr phosphorylation analysis; ChIP of Pgr on mmp15 promoter; follicle ovulation assay; CDK9/cyclin I co-expression and association demonstrated Cells Medium 30836650
2022 MMP15 expression in renal carcinoma cells is regulated by ERK1/2 and p38MAPK signaling; combined siRNA knockdown of ERK or p38MAPK with asiatic acid treatment further reduces MMP15 expression and metastatic activity. siRNA knockdown of ERK and p38MAPK; MMP-15 protein/mRNA quantification; ELISA for secreted MMP15; in vivo lung metastasis model; pharmacological inhibition with asiatic acid Phytomedicine Low 35316724

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. The Journal of biological chemistry 427 7559440
2009 Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proceedings of the National Academy of Sciences of the United States of America 179 19915148
2001 Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway. The Journal of biological chemistry 147 11584019
2009 MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Developmental cell 112 19853562
2007 The first trimester human trophoblast cell line ACH-3P: a novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations--TNF-alpha stimulates MMP15 expression. BMC developmental biology 80 18093301
2005 Identification of MMP-15 as an anti-apoptotic factor in cancer cells. The Journal of biological chemistry 68 16093241
2006 TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. The Journal of biological chemistry 58 16825197
2019 LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15. Cell biology international 55 30599080
1997 Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product. FEBS letters 53 9037199
2011 Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. Developmental biology 45 21920357
2012 Multiple steps of HLA-G in ovarian carcinoma metastasis: alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression. Human immunology 42 23228395
2012 Obesity-associated dysregulation of calpastatin and MMP-15 in adipose-derived stromal cells results in their enhanced invasion. Stem cells (Dayton, Ohio) 40 22969001
2000 Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester. Placenta 39 10736239
2019 LncRNA MAFG-AS1 promotes the aggressiveness of breast carcinoma through regulating miR-339-5p/MMP15. European review for medical and pharmacological sciences 38 31002134
2011 Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1α in cancer cells. Molecular carcinogenesis 36 21751260
2010 Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer. Anticancer research 34 21036765
2001 Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells. European journal of dermatology : EJD 32 11525948
2016 MT2-MMP induces proteolysis and leads to EMT in carcinomas. Oncotarget 30 27374080
2020 Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer. Aging 29 33323547
2010 The role of MT2-MMP in cancer progression. Biochemical and biophysical research communications 26 20117087
1997 Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. Genomics 26 9070935
2020 Long noncoding RNA ZFAS1 silencing alleviates rheumatoid arthritis via blocking miR-296-5p-mediated down-regulation of MMP-15. International immunopharmacology 25 33191176
2016 Functional roles of MMP14 and MMP15 in early postnatal mammary gland development. Development (Cambridge, England) 25 27633994
2022 Asiatic acid from centella asiatica exert anti-invasive ability in human renal cancer cells by modulation of ERK/p38MAPK-mediated MMP15 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology 22 35316724
2017 E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine. Journal of cell science 21 29061881
2016 T cell factor-4 functions as a co-activator to promote NF-κB-dependent MMP-15 expression in lung carcinoma cells. Scientific reports 19 27046058
2014 MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer. International journal of clinical and experimental pathology 19 25031779
2019 The oncoprotein HBXIP facilitates metastasis of hepatocellular carcinoma cells by activation of MMP15 expression. Cancer management and research 18 31191014
2012 MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin. PloS one 15 22768148
2020 Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity. Medicine 14 32049862
2012 Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 13 22998427
2019 Nuclear Progestin Receptor Phosphorylation by Cdk9 Is Required for the Expression of Mmp15, a Protease Indispensable for Ovulation in Medaka. Cells 12 30836650
2020 Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression. International journal of molecular sciences 11 32887509
2024 m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA. Cell & bioscience 10 39004750
2012 MT2-MMP expression during early avian morphogenesis. Anatomical record (Hoboken, N.J. : 2007) 10 23161772
2021 Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 8 35062057
2019 Inhibition of medaka ovulation by gap junction blockers due to its disrupting effect on the transcriptional process of LH-induced Mmp15 expression. General and comparative endocrinology 6 31874135
2022 MT2-MMP is differentially expressed in multiple myeloma cells and mediates their growth and progression. Cellular signalling 5 35041985
2022 Investigation of the HelioVital filter foil revealed protective effects against UVA1 irradiation-induced DNA damage and against UVA1-induced expression of matrixmetalloproteinases (MMP) MMP1, MMP2, MMP3 and MMP15. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 5 35174452
2024 MMP-14 Exhibits Greater Expression, Content and Activity Compared to MMP-15 in Human Renal Carcinoma. International journal of molecular sciences 4 39125675
2022 A New Model for Predicting Nonsentinel Lymph Node Metastasis in Early-Stage Breast Cancer Using MMP15. Journal of oncology 2 36035312
1998 Localization of the human membrane-type 2 matrix metalloproteinase gene (MMP15) to 16q12.1 near DNA elements that are part of centromeric and non-centromeric heterochromatin of 11 human chromosomes. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2 9609663
2025 Downregulation of MT2-MMP and MT5-MMP in ulcerative colitis serves a diagnostic predictor and potential therapeutic targets. Molecular biology reports 0 40178713
1997 Assignment of human membrane-type matrix metalloproteinase-2 (MT2-MMP) gene to 16q12 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis. DNA research : an international journal for rapid publication of reports on genes and genomes 0 9179500