Affinage

MMP14

Matrix metalloproteinase-14 · UniProt P50281

Length
582 aa
Mass
65.9 kDa
Annotated
2026-04-28
100 papers in source corpus 47 papers cited in narrative 46 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP14 (MT1-MMP) is a type-I transmembrane metalloproteinase that serves as a master regulator of pericellular proteolysis, cleaving ECM components (collagens, fibronectin, laminin, elastin) and cell-surface substrates (endoglin, Dll1, ADAM9, insulin receptor, GFRAL, VEGFR1, TSP1, pro-αv integrin) to control tissue invasion, angiogenesis, osteogenesis, hematopoiesis, myogenesis, and metabolic homeostasis (PMID:20424116, PMID:22632802, PMID:21572390, PMID:35768470, PMID:35177851, PMID:31278967, PMID:16926191). Its delivery to invadopodia and other invasive structures is governed by an elaborate endosomal trafficking network involving Rab8/GRAF2/WDR44-dependent exocytosis, WASH/exocyst-mediated late-endosomal tubulation, ARF6/JIP3/JIP4-coordinated motor activity, SNX27-retromer recycling, and FAK/Src-dependent suppression of endocytosis, with palmitoylation at Cys574 and phosphorylation at Thr567 directing internalization route and recycling (PMID:17332756, PMID:24344185, PMID:26504170, PMID:31820782, PMID:16054026, PMID:32205364, PMID:32344433). Beyond proteolysis, the cytoplasmic tail of MT1-MMP mediates non-catalytic functions: it binds p130Cas to activate Rac1 for macrophage fusion during osteoclastogenesis, tethers to F-actin via N-WASP and radixin to stabilize surface protease pools and mark podosome re-emergence sites, and sequesters FIH-1 through Mint3 to activate HIF-1α signaling under normoxia via mTOR-dependent Mint3 phosphorylation (PMID:20152179, PMID:23091069, PMID:26289026, PMID:27069022, PMID:24164895). MT1-MMP also activates latent TGFβ1 in macrophages and endothelial cells to drive endothelial-to-mesenchymal transition and angiogenesis, and its protein levels are controlled by GALNT1-mediated O-glycosylation in the ER and FBXO6-dependent ubiquitin-proteasomal degradation downstream of TGFβ-SMAD signaling (PMID:33063665, PMID:18541723, PMID:29136507, PMID:32409323).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2004 High

    Establishing how MT1-MMP reaches the cell surface in the absence of canonical furin processing: an unconventional BFA-resistant pathway delivers the zymogen to the plasma membrane where it undergoes autocatalytic activation and then functions as a prointegrin convertase, broadening its substrate repertoire beyond ECM components.

    Evidence Furin-negative LoVo cells, BFA treatment, surface biotinylation, integrin maturation assays, and in vivo tumor growth

    PMID:14729066 PMID:15260832

    Open questions at the time
    • Whether autocatalytic activation is quantitatively significant in furin-expressing tissues
    • Structural basis of the unconventional trafficking route
  2. 2005 High

    Defining how post-translational modification and endocytic regulators control MT1-MMP surface residence: palmitoylation at Cys574 directs clathrin-mediated internalization and migration, while FAK/Src phosphorylation of endophilin A2 suppresses MT1-MMP endocytosis, establishing that surface protease levels are dynamically regulated by endocytic machinery.

    Evidence Palmitoylation-deficient C574A mutant, endophilin A2 Tyr315 phosphorylation mutagenesis, dominant-negative dynamin, surface biotinylation, and migration assays

    PMID:15946988 PMID:16054026

    Open questions at the time
    • Identity of the palmitoyl acyltransferase
    • How palmitoylation and phosphorylation signals are integrated in real time
  3. 2007 High

    Identification of the first Rab GTPase pathway for polarized MT1-MMP exocytosis: β1 integrin-mediated adhesion to collagen triggers Rab8-dependent vesicular delivery of MT1-MMP to invasive structures, establishing the paradigm that ECM engagement feeds back to direct protease trafficking.

    Evidence Dominant-active/negative Rab8 mutants, siRNA of Rab8 vs Rab11, live-cell imaging, collagen invasion assay

    PMID:17332756

    Open questions at the time
    • Role of other Rab family members (later addressed by Rab2A and Rab10 studies)
    • Cargo adaptor linking Rab8 vesicles to MT1-MMP
  4. 2008 High

    Demonstrating that MT1-MMP activates latent TGFβ on endothelial cells downstream of PGE2, linking prostaglandin signaling to MT1-MMP-dependent TGFβ/Alk5/Smad3 activation and neovascularization — a non-ECM proteolytic function with paracrine signaling consequences.

    Evidence MT1-MMP knockdown, TGFβ activation assays, Smad3 nuclear translocation, in vivo neovascularization model

    PMID:18541723

    Open questions at the time
    • Which latent TGFβ complex component is directly cleaved by MT1-MMP
    • Relative contribution vs. other MT-MMPs in vivo
  5. 2010 High

    Revealing a catalysis-independent function of the MT1-MMP cytoplasmic tail: it binds p130Cas to activate Rac1 and direct membrane Rac1 targeting, which is required for macrophage fusion during osteoclastogenesis — the first clear demonstration that MT1-MMP signals independently of its protease domain.

    Evidence MT1-MMP-null mice with retroviral rescue using catalytic-dead mutants, Rac1 GTPase assay, osteoclastogenesis in vitro and in vivo

    PMID:20152179

    Open questions at the time
    • Whether p130Cas interaction is direct or adaptor-mediated
    • Contribution of this pathway in non-myeloid cell fusion events
  6. 2011 High

    Expanding the substrate repertoire to Notch ligands and fibronectin turnover: MT1-MMP cleaves Dll1 on stromal cells to modulate Notch signaling in hematopoietic progenitors, and regulates fibronectin turnover through both direct proteolysis and control of α5β1 integrin endocytosis.

    Evidence MT1-MMP-null mice, recombinant MT1-MMP cleavage of synthetic Dll1, DAPT rescue of B-cell development; MT1-MMP-null cell fibronectin and integrin trafficking assays

    PMID:21572390 PMID:22159414

    Open questions at the time
    • Whether other Notch ligands are similarly processed
    • Structural determinants of Dll1 cleavage specificity
  7. 2012 High

    Demonstrating genetic epistasis between MT1-MMP and ADAM9 in osteogenesis: MT1-MMP forms a ternary complex with FGFR2 and ADAM9, proteolytically inactivating ADAM9 to prevent FGFR2 shedding; Adam9 depletion rescues calvarial bone defects in Mmp14−/− embryos, establishing protease-protease crosstalk as a key mechanism.

    Evidence Mmp14-/- mice with Adam9 knockdown rescue, co-IP of ternary complex, in vitro cleavage, FGF signaling readouts

    PMID:22632802

    Open questions at the time
    • Whether this mechanism operates in postnatal bone remodeling
    • Involvement of additional ADAMs
  8. 2013 High

    Mapping the late-endosomal trafficking machinery: WASH and the exocyst complex cooperate on MT1-MMP-containing late endosomes to generate tubular connections for exocytic delivery to invadopodia, while tetraspanins associate with MT1-MMP via its hemopexin domain in the ER to differentially regulate surface presentation.

    Evidence siRNA of WASH/exocyst components, live-cell imaging of endosomal tubules; yeast two-hybrid and co-IP panel for tetraspanins, domain deletion mutants

    PMID:23500527 PMID:24344185

    Open questions at the time
    • How WASH-exocyst selects MT1-MMP cargo over other membrane proteins
    • Structural basis of hemopexin-tetraspanin interaction
  9. 2013 High

    Revealing the MT1-MMP/Mint3/FIH-1/mTOR axis for normoxic HIF-1α activation: the cytoplasmic tail sequesters FIH-1 via Mint3, whose inhibitory function requires mTOR-dependent phosphorylation, linking MT1-MMP to metabolic reprogramming in tumors.

    Evidence Inhibitor screen (252 compounds), rapamycin treatment, phosphorylation-deficient Mint3 mutants, xenograft assays

    PMID:24164895

    Open questions at the time
    • Which mTOR complex (mTORC1 vs mTORC2) phosphorylates Mint3
    • Whether this HIF-1α mechanism operates in non-tumor contexts
  10. 2015 High

    Structural determination of how the cytoplasmic tail connects to cortical actin: crystal structure of the MT1-MMP tail/radixin FERM complex reveals an antiparallel β-β interaction that simultaneously positions MT1-MMP and its substrate CD44 at the actin cortex; ARF6/JIP3/JIP4 coordinate dynein-kinesin tug-of-war for MT1-MMP endosome motility.

    Evidence Crystal structure (MT1-MMP tail–radixin FERM), CD44 shedding assay; siRNA/co-IP/dominant-negative ARF6/JIP constructs, live-cell imaging

    PMID:26289026 PMID:26504170

    Open questions at the time
    • Whether other ERM proteins can substitute for radixin
    • How JIP3/4 selectivity for MT1-MMP endosomes is achieved
  11. 2016 High

    Multiple trafficking regulators converge on MT1-MMP surface delivery: RAB2A/VPS39 controls post-endocytic sorting, TOM1L1/TOLLIP directs ERBB2-dependent trafficking to invadopodia, and MT1-MMP islets on the macrophage surface serve as cytoskeleton-anchored spatial memory for podosome reformation.

    Evidence siRNA screen of RAB GTPases, co-IP of RAB2A-VPS39; TOM1L1 Ser321 mutagenesis, co-IP with TOLLIP; TIRF microscopy of MT1-MMP islets with tail truncation mutants

    PMID:26899482 PMID:27069022 PMID:27255086

    Open questions at the time
    • Whether RAB2A and TOM1L1 pathways operate in the same or parallel trafficking routes
    • Molecular basis of islet spatial memory
  12. 2017 High

    ER-localized GALNT1-mediated O-glycosylation activates MMP14 for matrix degradation and invasion, establishing that MMP14 activity is regulated at a biosynthetic step before reaching the cell surface.

    Evidence ER-targeted GALNT1 expression, MMP14 glycosylation biochemistry, mouse liver cancer model

    PMID:29136507

    Open questions at the time
    • Specific O-glycosylation sites on MMP14 required for activation
    • Whether Golgi-localized GALNT1 has any residual effect
  13. 2019 High

    Dissecting proteolytic vs. non-proteolytic roles at invadopodia: MT1-MMP directs invadopodia assembly independently of catalytic activity, but its proteolytic matrix pore-widening is required for actin polymerization-driven protrusive invasion; simultaneously, MT1-MMP is shown to cleave elastin and TSP1 to generate bioactive fragments promoting vasodilation and angiogenesis.

    Evidence Electron microscopy of invadopodia, catalytic-dead mutants, force measurements; in vitro elastin/TSP1 digestion with mass spectrometry; endothelial-specific MT1-MMP conditional KO

    PMID:31278967 PMID:31653854 PMID:31793743

    Open questions at the time
    • Quantitative contribution of pore widening vs. chemical signaling in vivo
    • Full repertoire of bioactive fragments generated from elastin cleavage
  14. 2020 High

    Expanding MT1-MMP's physiological roles to metabolic regulation and cardiac fibrosis: MT1-MMP cleaves the insulin receptor and GFRAL to suppress insulin sensitivity and anorectic signaling during aging/obesity, and macrophage MT1-MMP activates TGFβ1 to drive endothelial-to-mesenchymal transition after myocardial infarction. MMP14 protein stability is controlled by FBXO6-mediated ubiquitination downstream of TGFβ-SMAD signaling.

    Evidence Neuron-specific and macrophage-specific conditional KOs, in vitro cleavage assays, aged/diabetic mouse models, FBXO6 KO mice and ubiquitination assays

    PMID:32409323 PMID:33063665 PMID:35177851 PMID:35768470

    Open questions at the time
    • Whether insulin receptor cleavage occurs at a specific domain or multiple sites
    • Tissue-specific regulation of FBXO6-MMP14 axis
  15. 2020 High

    Completing the exocytic trafficking map: GRAF2 and WDR44 mediate Rab8/10/11-dependent export of newly synthesized MMP14 via ER-aligned tubular endosomes, and β1 integrin activation induces Src-EGFR-dependent Thr567 phosphorylation to promote MT1-MMP recycling to invadopodia, and SNX27-retromer selectively recycles MT1-MMP from endosomes.

    Evidence Dominant-negative GRAF1/2 and WDR44, co-IP, ITC for SNX27-retromer direct binding, Thr567 phosphorylation site analysis, xenograft models

    PMID:31820782 PMID:32205364 PMID:32344433

    Open questions at the time
    • How SNX27 vs. GRAF2/WDR44 pathways are temporally coordinated
    • Whether Thr567 phosphorylation affects substrate selectivity

Open questions

Synthesis pass · forward-looking unresolved questions
  • A comprehensive structural model explaining how the hemopexin domain, transmembrane domain, and cytoplasmic tail collectively integrate substrate recognition, membrane trafficking, and non-catalytic signaling remains unresolved.
  • Full-length MT1-MMP structure in a membrane context is lacking
  • Quantitative in vivo flux through each trafficking pathway has not been measured
  • How MT1-MMP activity is coordinated across different cell types within the same tissue microenvironment is undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 10 GO:0016787 hydrolase activity 6 GO:0060090 molecular adaptor activity 3
Localization
GO:0005886 plasma membrane 8 GO:0005768 endosome 7 GO:0031410 cytoplasmic vesicle 5 GO:0005783 endoplasmic reticulum 2 GO:0005576 extracellular region 1
Pathway
R-HSA-9609507 Protein localization 9 R-HSA-162582 Signal Transduction 8 R-HSA-1474244 Extracellular matrix organization 6 R-HSA-5653656 Vesicle-mediated transport 6 R-HSA-1266738 Developmental Biology 3 R-HSA-1430728 Metabolism 2
Partners
ADAM12ADAM9APBA1FURINRDXSNX27TIMP2WASL
Complex memberships
MT1-MMP/ADAM12/αVβ3 integrin ternary complexMT1-MMP/Mint3/FIH-1 signaling complexMT1-MMP/TIMP-2/proMMP-2 activation complex

Evidence

Reading pass · 46 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 MMP-14 (MT1-MMP) is the major protease responsible for shedding of endoglin from the cell surface. Endoglin shedding required direct protein-protein interaction between endoglin and membrane-localized MMP-14, and MMP-14 cleaved endoglin at a site proximal to the transmembrane domain. MMP-14 shRNA and MMP inhibitors blocked soluble endoglin release. shRNA knockdown, co-expression studies, cleavage site mutagenesis, MMP inhibitor treatment Cancer research High 20424116 22296769
2007 MT1-MMP proinvasive activity is regulated by a Rab8-dependent exocytic pathway. Beta1 integrin-mediated adhesion to collagen triggers polarized exocytosis of MT1-MMP via Rab8-positive vesicles (not Rab11-positive compartments) to invasive structures, and constitutively active Rab8 induces MT1-MMP exocytic traffic, collagen degradation, and invasion. Dominant-active/dominant-negative Rab8 mutants, siRNA knockdown of Rab8 vs Rab11, live-cell imaging, collagen invasion assay The EMBO journal High 17332756
2005 FAK promotes cell-surface presentation of MT1-MMP by inhibiting endophilin A2-dependent endocytosis. FAK interacts via its second Pro-rich motif with endophilin A2's SH3 domain; Src phosphorylates endophilin A2 at Tyr315, which blocks endophilin/dynamin interaction and thereby inhibits MT1-MMP endocytosis, increasing surface MT1-MMP and ECM degradation. Co-immunoprecipitation, phosphorylation site mutagenesis, dominant-negative dynamin, ECM degradation assays, surface biotinylation Developmental cell High 16054026
2013 WASH (endosomal Arp2/3 activator) and the exocyst complex interact on MT1-MMP-containing late endosomes and together are required for MT1-MMP exocytic delivery to invadopodia via tubular connections between late endosomes and plasma membrane. Co-immunoprecipitation, siRNA knockdown of WASH and exocyst components, live-cell imaging of endosomal tubules, ECM degradation assay The Journal of cell biology High 24344185
2012 N-WASP promotes trafficking of MT1-MMP into invasive pseudopodia from late endosomes and stabilizes MT1-MMP at the plasma membrane via direct tethering of MT1-MMP's cytoplasmic tail to F-actin, coupling matrix remodeling with protrusive invasion. siRNA knockdown, live-cell imaging, co-immunoprecipitation of MT1-MMP cytoplasmic tail with F-actin/N-WASP, 3D invasion assays The Journal of cell biology High 23091069
2015 ARF6, together with its effectors JIP3 and JIP4, regulates MT1-MMP endosomal positioning and exocytosis. JIPs are recruited by WASH on MT1-MMP endosomes and recruit dynein-dynactin and kinesin-1; plasma membrane ARF6 interacts with endosomal JIPs to coordinate motor activity in a tug-of-war mechanism, driving MT1-MMP endosome tubulation and exocytosis. siRNA silencing, co-immunoprecipitation, dominant-negative constructs, live-cell imaging, invasion assays The Journal of cell biology High 26504170
2005 MT1-MMP is palmitoylated at Cys574 in its cytoplasmic domain; this modification is required for clathrin-mediated internalization and for MT1-MMP-dependent cell migration. The palmitoylation-deficient C574A mutant undergoes caveolae-dependent internalization instead and fails to promote cell migration. Palmitoylation-deficient mutagenesis (C574A), internalization assays, caveolae vs. clathrin pathway inhibitors, cell migration assays FASEB journal High 15946988
2014 Atypical PKCι (aPKCι) promotes delivery of MT1-MMP from late endosomal compartments to the plasma membrane by phosphorylating cortactin, which regulates cortactin association with the membrane scission protein dynamin-2 on MT1-MMP-positive endosomes. siRNA silencing of aPKC, phosphorylation assays, co-localization studies, ECM degradation and invasion assays PNAS High 24753582
2010 MT1-MMP is required for macrophage/myeloid cell fusion during osteoclast and giant-cell formation. The cytoplasmic tail of MT1-MMP (independent of catalytic activity) associates with p130Cas and thereby regulates Rac1 activity and membrane targeting of Rac1, which is required for lamellipodia formation and proper cell migration prior to fusion. MT1-MMP-null mice, retroviral rescue with catalytic-dead mutants, protein binding assays (co-IP), Rac1 GTPase activity assay, in vitro and in vivo osteoclastogenesis assays Developmental cell High 20152179
2012 MT1-MMP forms a complex with FGFR2 and ADAM9 on osteoblasts and proteolytically inactivates ADAM9, preventing ADAM9-mediated ectodomain shedding of FGFR2. Loss of MT1-MMP increases ADAM9 activity and FGFR2 shedding, impairing FGF-induced proliferation; Adam9 depletion fully rescues defective FGFR2 signaling and largely restores calvarial bone growth in Mmp14−/− embryos. Genetic epistasis (Mmp14-/- mice, Adam9 knockdown rescue), co-immunoprecipitation, in vitro cleavage assays, FGF signaling readouts Developmental cell High 22632802
2011 MT1-MMP expressed in bone marrow stromal cells cleaves the Notch ligand Delta-like 1 (Dll1) on the cell surface, reducing Notch signaling in hematopoietic progenitor cells and thereby maintaining normal B-lymphocyte development. Recombinant MT1-MMP cleaves a synthetic Dll1 peptide at the same site. MT1-MMP-null mice, co-culture experiments, DAPT (Notch inhibitor) rescue, direct cleavage of synthetic Dll1 peptide by recombinant MT1-MMP, co-immunoprecipitation of MT1-MMP with Dll1 The EMBO journal High 21572390
2013 MT1-MMP cytoplasmic tail activates HIF-1 in cancer cells during normoxia by binding and inhibiting FIH-1 (a HIF-1 suppressor) through Mint3. mTOR phosphorylates Mint3, which is required for FIH-1 inhibition; rapamycin blocks this phosphorylation and reduces HIF-1 activity. Inhibitor screen (252 compounds), mTOR inhibitor (rapamycin) treatment, phosphorylation-deficient Mint3 mutants, tumor xenograft assays Molecular and cellular biology High 24164895
2017 GALNT1-mediated O-glycosylation of MMP14 in the endoplasmic reticulum (ER), but not in the Golgi, activates MMP14 and promotes matrix degradation and tissue invasion. ER-targeted GALNT1 glycosylates MMP14, a process required for tumor expansion in a mouse liver cancer model. ER-targeted GALNT1 expression, MMP14 glycosylation biochemical analysis, in vivo mouse liver cancer model, invasion and matrix degradation assays Cancer cell High 29136507
2020 FBXO6, an E3 ubiquitin ligase subunit, ubiquitinates MMP14 leading to its proteasomal degradation; TGFβ-SMAD2/3 signaling upregulates FBXO6 transcription, thereby suppressing MMP14 levels and MMP14-dependent proteolytic activation of MMP13 in cartilage. Co-immunoprecipitation (FBXO6-MMP14 interaction), FBXO6 global and conditional KO mice, ubiquitination assays, SMAD2-/- mice, OA models Annals of the rheumatic diseases High 32409323
2020 In macrophages after myocardial infarction, MT1-MMP activates latent TGFβ1, which acts paracrine via SMAD2 signaling in endothelial cells to drive endothelial-to-mesenchymal transition (EndMT) and cardiac fibrosis. Macrophage-specific Mmp14 knockout attenuated post-MI cardiac dysfunction and reduced EndMT. Macrophage-specific conditional KO (Mmp14f/f:Lyz2-Cre), co-culture assays, SMAD2 phosphorylation readout, 3D cardiac imaging eLife High 33063665
2022 MT1-MMP cleaves the Insulin Receptor to suppress insulin signaling during ageing and obesity. MT1-MMP activation increases in insulin-sensitive tissues with age; MT1-MMP inhibition restores Insulin Receptor expression and improves insulin sensitivity in aged and diabetic mouse models. MT1-MMP overexpression in liver (reducing Insulin Receptor), MT1-MMP inhibition in aged/diabetic mice, in vitro cleavage assays, plasma biomarker correlation in humans and non-human primates Nature communications High 35768470
2022 MT1-MMP proteolytically cleaves GFRAL (the cognate receptor of GDF15) in GFRAL+ neurons, inactivating GDF15-GFRAL anorectic signaling in obese mice. Neuron-specific MT1-MMP ablation restored GFRAL expression and reduced weight gain and food intake in obese mice. Neuron-specific (GFRAL+) MT1-MMP conditional KO, GFRAL-deficient rescue experiment, in vivo body weight and food intake measurements, in vitro cleavage assays Nature metabolism High 35177851
2004 In furin-negative cancer cells, MT1-MMP zymogen traffics to the plasma membrane via a Brefeldin A-resistant (unconventional) pathway and undergoes autocatalytic processing on the cell surface. Active MT1-MMP then acts as a prointegrin convertase, cleaving pro-αv integrin to generate the mature αvβ3 heterodimer. Furin-negative cell system (LoVo cells), Brefeldin A treatment, surface biotinylation, integrin maturation assays, invasion and tumor growth in vivo Traffic (Copenhagen, Denmark) High 15260832
2013 ADAM12 recruits endogenous MMP-14 to the cell surface via a ternary complex with αVβ3 integrin, promoting MMP-14 activation, gelatin degradation, and protection of tumor cells from apoptosis. Neither ADAM12 catalytic activity nor its cytoplasmic tail were required for MMP-14 activation in this complex. Co-immunoprecipitation, surface recruitment assays, ADAM12-specific monoclonal antibodies, orthotopic xenograft model, apoptosis assays Journal of cell science High 24006261
2015 The cytoplasmic tail of MT1-MMP directly binds the FERM domain of radixin (ERM protein); crystal structure shows the central region of MT1-MMP tail makes antiparallel β-β interaction with subdomain A of the FERM domain. Radixin simultaneously binds MT1-MMP and CD44, co-localizing protease and substrate at F-actin and accelerating CD44 shedding. Crystal structure of MT1-MMP cytoplasmic tail / radixin FERM complex, co-immunoprecipitation, CD44 shedding assays Genes to cells High 26289026
2016 MT1-MMP islet formation at the plasma membrane of macrophages depends on the cytoplasmic tail of MT1-MMP and its ability to bind the subcortical actin cytoskeleton (independent of proteolytic activity). MT1-MMP islets persist after podosome dissolution and act as spatial memory devices for podosome re-emergence. TIRF microscopy, siRNA knockdown, complementation with cytoplasmic tail truncation mutants, functional podosome reformation assays The Journal of cell biology High 27069022
2011 MT1-MMP regulates fibronectin turnover by two mechanisms: (1) extracellular proteolytic cleavage of fibronectin, and (2) regulation of α5β1-integrin endocytosis. Cells lacking MT1-MMP show reduced ECM fibronectin turnover, and fibronectin polymerization inhibits α5β1-integrin endocytosis by stabilizing fibrils. MT1-MMP-null cells, ECM fibronectin turnover/endocytosis assays, integrin trafficking assays Journal of cell science High 22159414
2006 MT1-MMP is required for myoblast elongation and cell fusion during myogenic differentiation, acting independently of the genetic myogenic transcription program. MT1-MMP degrades fibronectin (a fusion inhibitor) and cleaves laminin-2/4 in the basement membrane at distinct differentiation stages. MMP inhibitor treatment of differentiating myoblasts, MT1-MMP-null mice, in vitro differentiation assays with stage-specific substrate readouts Journal of cell science High 16926191
2008 PGE2 induces MT1-MMP membrane clustering on endothelial cells; MT1-MMP then releases active TGFβ from its latent form, activating Alk5-Smad3 signaling and endothelial tube formation/neovascularization. MT1-MMP-dependent TGFβ activation is required for PGE2-induced angiogenesis. MT1-MMP knockdown, Smad3 nuclear translocation assays, TGFβ activation assays, in vitro cord formation, in vivo neovascularization model Blood High 18541723
2019 MT1-MMP directs invadopodia assembly independent of its proteolytic activity; however, MT1-MMP matrix-degradative activity is required to widen matrix pores, enabling actin polymerization-driven pushing forces to generate the invasive pathway. Electron microscopy reveals polymerized Arp2/3 actin network at concave side of invadopodia. Electron microscopy of invadopodia ultrastructure, catalytic-dead MT1-MMP mutants, force measurements, 3D collagen invasion assay Nature communications High 31653854
2016 RAB2A controls post-endocytic trafficking of MT1-MMP by interacting with VPS39 (a component of the late endosomal HOPS complex), and separately regulates Golgi transport of E-cadherin, thereby controlling tumor invasiveness. Functional siRNA screen of human RAB GTPases, co-immunoprecipitation (RAB2A with VPS39), MT1-MMP trafficking assays, 3D invasion assays EMBO reports High 27255086
2020 GRAF2 and WDR44 mediate Rab8/10/11-dependent exocytic export of newly synthesized MMP14 to the plasma membrane. WDR44 labels tubular endosomes aligned with ER via VAPA/B; GRAF2 BAR domain tubulates membranes and is required for WDR44 tubule formation. Dominant-negative GRAF1/2 and WDR44 mutants, co-immunoprecipitation, endosome tubulation imaging, MMP14 surface delivery assays The Journal of cell biology High 32344433
2013 Tetraspanins (CD9, CD37, CD53, CD63, CD81, CD82) and tetraspanin-like MAL protein associate with MT1-MMP through its hemopexin domain in the endoplasmic reticulum, independently of O-glycosylation. Different tetraspanins differentially affect MT1-MMP cell-surface localization, pro-MMP-2 activation, and collagen invasion capacity. Yeast two-hybrid screen (identified EWI-2 interaction), co-immunoprecipitation panel, MT1-MMP truncation and domain mutants, pro-MMP-2 activation assay, collagen invasion assay The international journal of biochemistry & cell biology High 23500527
2016 TOM1L1 is phosphorylated on Ser321 downstream of ERBB2, promoting GAT domain-dependent association with the sorting protein TOLLIP and driving trafficking of MT1-MMP from endocytic compartments to invadopodia for ECM degradation and tumor invasion. Phosphorylation site mutagenesis (Ser321), co-immunoprecipitation (TOM1L1-TOLLIP), MT1-MMP trafficking assays, invadopodia ECM degradation assays, breast cancer cell invasion Nature communications High 26899482
2020 SNX27-retromer selectively recycles MT1-MMP (but not MT2-MMP) from endosomes to invadopodia. ITC-based studies showed both SNX27 and retromer can directly interact with MT1-MMP, and SNX27 depletion reduced matrix degradation and tumor invasion in xenograft models. ITC (isothermal titration calorimetry) for direct binding, siRNA knockdown of SNX27/retromer, MT1-MMP recycling assays, ECM degradation assays, SCID mouse xenograft survival The Journal of cell biology High 31820782
2004 TIMP-2 is released primarily as an intact functional molecule (>85%) after binding to MT1-MMP on the cell surface; furin-mediated activation of proMT1-MMP is required for TIMP-2 binding and subsequent endocytosis. Dynamin-dependent endocytosis mediates TIMP-2 cellular entry. 125I-TIMP-2 binding and release assays, dominant-negative dynamin transfection, furin inhibitor treatment, surface biotinylation of MT1-MMP Experimental cell research High 14729066
2012 MT1-MMP knockdown (but not MMP1, 3, or 13) inhibited fibroblast-mediated collagen contraction in Dupuytren's disease, and MT1-MMP knockdown prevented proMMP-2 activation in this contraction model. MMP-2 knockdown also inhibited contraction, demonstrating MT1-MMP acts upstream of MMP-2 in this process. siRNA knockdown of specific MMPs, fibroblast-populated collagen lattice (FPCL) contraction model, proMMP-2 activation assay Biochimica et biophysica acta Medium 22342364
2007 MT1-MMP cleaves collagen fibrils on the cell surface and is required for collagen phagocytosis by fibroblasts and highly metastatic cancer cells. MT1-MMP (but not MMP-2) localizes to sites of collagen cleavage on the cell surface and within cells at phagocytic structures. Laser confocal microscopy, transmission electron microscopy, biochemical cleavage assays, MT1-MMP expression correlation with phagocytosis Biochemical Society transactions Medium 17635128
2019 MT1-MMP in endothelial cells cleaves thrombospondin-1 (TSP1); the C-terminal fragment of TSP1 binds CD47/αvβ3 integrin to promote nitric oxide production, vasodilation, and intussusceptive angiogenesis during colitis. Endothelial-specific MT1-MMP conditional KO mice, lentiviral rescue, intravital microscopy, TSP1 cleavage assays, integrin binding peptide competition EMBO molecular medicine High 31793743
2016 KLF6 transcription factor directly binds the MMP14 gene promoter (shown by ChIP assay) and upregulates MMP14 transcription, leading to increased soluble endoglin release via MMP14-mediated endoglin shedding during vascular injury/wound healing. ChIP assay (KLF6-MMP14 promoter interaction), promoter reporter assays, siRNA knockdown of KLF6, Klf6+/- mice with wire-induced denudation Angiogenesis High 26850053
2018 PROX1 transcription factor suppresses MMP14 transcription by binding and inhibiting the MMP14 promoter. PROX1 deletion in murine dermal lymphatic vessels and in human LECs increased MMP14 expression; PROX1 silencing increased MMP14-dependent 3D invasion. Promoter binding assay, in vivo conditional Prox1 deletion in lymphatic endothelium, siRNA silencing in human LECs, 3D invasion assays Scientific reports High 29934628
2008 MT1-MMP suppresses DKK3 gene transcription, and knockdown of MT1-MMP markedly upregulates DKK3 mRNA (at the transcriptional, not mRNA stability, level); DKK3 is an invasion inhibitor, and this transcriptional regulation of DKK3 by MT1-MMP contributes to urothelial cell invasion. siRNA knockdown of MT1-MMP, expression arrays, DKK3 mRNA stability assays, overexpression of DKK3, invasion assays British journal of cancer Medium 18665176
2020 β1 integrin activation induces phosphorylation of MT1-MMP at Thr567 via a Src-EGFR signaling pathway, promoting MT1-MMP internalization and recycling to invadopodia, and enhancing cancer cell invasiveness and invadopodium formation. β1 integrin activating antibody (P4G11), phosphorylation site analysis (Thr567), Src/EGFR inhibition, MT1-MMP internalization assays, invadopodium formation assays Journal of cell science High 32205364
2010 β-catenin in non-cancer cells directly interacts with the 18-amino-acid cytoplasmic tail of MT1-MMP to inhibit its cell-surface localization and proteolytic activity, while in cancer cells nuclear β-catenin activates MT1-MMP transcription via Tcf-4/Lef. Direct interaction assay (co-IP with MT1-MMP cytoplasmic tail), surface localization assay, pro-MMP-2 activation assay, promoter reporter assays, 3D collagen growth assays Journal of cellular physiology Medium 20589835
2016 MMP14 in exosomes derived from corneal fibroblasts cleaves VEGFR1 but not VEGFR2 in vitro, and MMP14-containing exosomes promote VEGFA-induced endothelial cell migration and proliferation; this cleavage was abrogated by pan-MMP inhibitor GM6001 and absent in exosomes from MMP14 exon4-deficient fibroblasts. In vitro proteolysis with recombinant VEGFR1/R2, MMP14-deficient fibroblast exosomes, GM6001 inhibitor, endothelial migration (Boyden chamber) and proliferation (BrdU) assays Investigative ophthalmology & visual science High 31117124
2019 MMP-14 cleaves tropoelastin and mature skin elastin in vitro, with cleavage preference for small/medium hydrophobic residues (Gly, Ala, Leu, Val) at P1'. Cleavage of mature skin elastin by MMP-14 releases bioactive elastin peptides. In vitro digestion of recombinant tropoelastin and human skin elastin with MMP-14; mass spectrometric peptide analysis; molecular docking studies Biochimie High 31278967
2013 CDCP1 colocalizes with MT1-MMP in caveolin-1/lipid raft-containing vesicular structures, co-immunoprecipitates with MT1-MMP, and its knockdown markedly inhibits MT1-MMP accumulation at invadopodia and MT1-MMP-dependent ECM degradation in breast cancer and melanoma cells. Co-immunoprecipitation of CDCP1 with MT1-MMP, siRNA knockdown of CDCP1, immunofluorescence of MT1-MMP at invadopodia, Matrigel invasion assay Molecular cancer research Medium 23439492
2014 Basal localization of MT1-MMP in polarized epithelial cells is required for collagen degradation and tubulogenesis. HGF induces basal redistribution of MT1-MMP; deletion of the MT-loop or hemopexin domain prevents basal localization. TGFβ at high doses inhibits basal MT1-MMP localization and tubulogenesis. MT1-MMP domain deletion mutants, HGF stimulation, TGFβ treatment, 3D collagen tubulogenesis assay, confocal imaging of MT1-MMP localization Journal of cell science High 24463815
2012 VANGL2 (a planar cell polarity protein) regulates the endocytosis and cell-surface availability of MMP14 in a FAK-dependent manner. Loss of Vangl2 in zebrafish leads to increased Mmp14 activity and decreased ECM; in vivo knockdown of Mmp14 partially rescues the Vangl2 loss-of-function convergence and extension phenotype. Zebrafish vangl2 mutants and Mmp14 morpholino knockdown, genetic epistasis (Vangl2/Mmp14 double knockdown rescue), MMP14 endocytosis assays, ECM quantification Journal of cell science High 22357946
2019 TMZ treatment promotes nuclear translocation of MMP14 in glioblastoma cells, followed by extracellular release of DLL4. DLL4 then stimulates cleavage of Notch3, its nuclear translocation, and induction of stemness/sphere formation capacity. Kiloplex ELISA-based protein array, subcellular fractionation of MMP14, functional sphere-formation assay, DLL4 siRNA rescue International journal of cancer Medium 31443114
2013 MT1-MMP drives a combinatorial proteolytic program in endothelial cells. Quantitative proteomics of MT1-MMP-null vs. wild-type endothelial cells identified substrates including TSP1, CYR61, NID1, and SEM3C; combined substrate processing determines biological outcomes for chemotaxis, adhesion, and angiogenesis. Quantitative proteomics (MT1-MMP-null vs. WT mouse endothelial cells), substrate validation assays, in vitro angiogenesis readouts FASEB journal High 22859368

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. Journal of cell science 382 19692588
2010 Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer research 231 20424116
2007 MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. The EMBO journal 209 17332756
2002 Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes. The Journal of experimental medicine 171 11828004
2005 FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Developmental cell 157 16054026
2013 Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. The Journal of cell biology 148 24344185
2004 MT1-MMP: a tethered collagenase. Journal of cellular physiology 144 15137053
2006 MT1-MMP: a key regulator of cell migration in tissue. IUBMB life 140 17050376
2012 N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. The Journal of cell biology 135 23091069
2017 Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. Cancer cell 121 29136507
2015 ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion. The Journal of cell biology 110 26504170
2006 MT1-MMP: universal or particular player in angiogenesis? Cancer metastasis reviews 106 16680574
2011 MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin. Journal of cell science 104 22159414
2006 Multifunctional roles of MT1-MMP in myofiber formation and morphostatic maintenance of skeletal muscle. Journal of cell science 102 16926191
2010 MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Developmental cell 99 20152179
2010 Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer research 91 20197470
2019 MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion. Nature communications 90 31653854
2019 MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms. Biochemical Society transactions 85 31064864
2016 RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO reports 81 27255086
2005 Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). American journal of physiology. Renal physiology 81 16077081
2016 Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality. Cell host & microbe 80 27736644
2015 CD44 regulates pancreatic cancer invasion through MT1-MMP. Molecular cancer research : MCR 77 25566991
2014 Control of MT1-MMP transport by atypical PKC during breast-cancer progression. Proceedings of the National Academy of Sciences of the United States of America 76 24753582
2020 TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Annals of the rheumatic diseases 74 32409323
2020 Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction. eLife 73 33063665
2014 RETRACTED: miR-150-5p inhibits hepatoma cell migration and invasion by targeting MMP14. PloS one 72 25549355
2020 circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis. Theranostics 70 32929380
2012 MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis. Developmental cell 70 22632802
2004 MT1-MMP: an enzyme with multidimensional regulation. Trends in biochemical sciences 69 15276180
2012 VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. Journal of cell science 62 22357946
2016 Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin. The Journal of investigative dermatology 61 27066886
2012 MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin. The American journal of pathology 60 22296769
2010 Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy. Molecular and cellular endocrinology 58 20887771
2008 Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer. Cancer research 58 18519667
2005 Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 58 15946988
2016 Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis 57 26850053
2007 MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells. British journal of cancer 57 17609667
2008 PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway. Blood 54 18541723
2013 Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP. Molecular and cellular biology 53 24164895
2022 Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu. International journal of molecular sciences 52 36076910
2014 The emerging role of MMP14 in brain tumorigenesis and future therapeutics. Biochimica et biophysica acta 52 24657728
2013 KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Oncogene 52 23812425
2013 ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth. Journal of cell science 52 24006261
2011 Secretory and endo/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm. European journal of cell biology 52 20605060
2016 Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence. The Journal of cell biology 49 27069022
2011 Role of MMP14 gene polymorphisms in susceptibility and pathological development to hepatocellular carcinoma. Annals of surgical oncology 48 21298348
2019 Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models. European journal of nuclear medicine and molecular imaging 46 31773232
2011 MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. The EMBO journal 45 21572390
2004 Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells. Traffic (Copenhagen, Denmark) 45 15260832
2018 TGF-β-induced NKILA inhibits ESCC cell migration and invasion through NF-κB/MMP14 signaling. Journal of molecular medicine (Berlin, Germany) 41 29379981
2020 SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis. The Journal of cell biology 40 31820782
2015 MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. American journal of translational research 40 26175856
2012 MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction. Biochimica et biophysica acta 38 22342364
2022 Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor. Nature communications 37 35768470
2019 Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis. EMBO molecular medicine 37 31793743
2016 TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion. Nature communications 37 26899482
2013 The tetraspanin network modulates MT1-MMP cell surface trafficking. The international journal of biochemistry & cell biology 37 23500527
2018 PROX1 is a transcriptional regulator of MMP14. Scientific reports 36 29934628
2016 Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas. International journal of cancer 36 27144841
2018 MMP14 Regulates Cranial Neural Crest Epithelial-to-Mesenchymal Transition and Migration. Developmental dynamics : an official publication of the American Association of Anatomists 35 30079980
2013 Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. Oncogene 35 24077288
2023 Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer. Cancer letters 34 37591356
2016 Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. PloS one 34 27462980
2007 Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP. Biochemical Society transactions 34 17635128
2013 Activated α2-macroglobulin induces Müller glial cell migration by regulating MT1-MMP activity through LRP1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 23640058
2015 Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis. International journal of clinical and experimental pathology 32 26097538
2023 MT1-MMP as a Key Regulator of Metastasis. Cells 31 37681919
2022 Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nature metabolism 31 35177851
2020 GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508. The Journal of cell biology 31 32344433
2013 CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells. Molecular cancer research : MCR 31 23439492
2008 Role of MT1-MMP in the osteogenic differentiation. Bone 31 19027888
2018 High serum MMP-14 predicts worse survival in gastric cancer. PloS one 30 30532247
2006 Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 30 16762015
2020 mir-22-3p/KLF6/MMP14 axis in fibro-adipogenic progenitors regulates fatty infiltration in muscle degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29 33000497
2019 MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells. Investigative ophthalmology & visual science 29 31117124
2021 The role of MMP-14 in ovarian cancer: a systematic review. Journal of ovarian research 28 34344453
2020 How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer. The Journal of clinical investigation 28 32015228
2016 Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption. Matrix biology : journal of the International Society for Matrix Biology 28 26780723
2012 The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27 22859368
2018 Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP. Clinical and experimental pharmacology & physiology 26 29781531
2008 MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3. British journal of cancer 26 18665176
2004 TIMP-2 is released as an intact molecule following binding to MT1-MMP on the cell surface. Experimental cell research 26 14729066
2016 Functional roles of MMP14 and MMP15 in early postnatal mammary gland development. Development (Cambridge, England) 25 27633994
2015 MT1-MMP recognition by ERM proteins and its implication in CD44 shedding. Genes to cells : devoted to molecular & cellular mechanisms 25 26289026
2001 Clinical significance of MT1-MMP mRNA expression in breast cancer. Oncology reports 25 11182063
2020 β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion. Journal of cell science 24 32205364
2021 Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth. International journal of molecular sciences 23 34830157
2012 Site-specific cellular functions of MT1-MMP. European journal of cell biology 23 22939226
2023 Bone sialoprotein promotes lung cancer osteolytic bone metastasis via MMP14-dependent mechanisms. Biochemical pharmacology 22 37028462
2021 LOXL1-AS1 communicating with TIAR modulates vasculogenic mimicry in glioma via regulation of the miR-374b-5p/MMP14 axis. Journal of cellular and molecular medicine 22 34890108
2019 TMZ regulates GBM stemness via MMP14-DLL4-Notch3 pathway. International journal of cancer 22 31443114
2018 SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14. Investigative ophthalmology & visual science 22 30452596
2021 lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression. Molecular therapy. Nucleic acids 21 34729248
2010 Regulation of MT1-MMP activity by β-catenin in MDCK non-cancer and HT1080 cancer cells. Journal of cellular physiology 21 20589835
1998 Expression of a progelatinase activator (MT1-MMP) in human fetal membranes. American journal of reproductive immunology (New York, N.Y. : 1989) 21 9602249
2019 MMP-14 degrades tropoelastin and elastin. Biochimie 20 31278967
2018 Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell. Oncotarget 20 30174795
2010 Involvement of MT1-MMP and TIMP-2 in human periodontal disease. Oral diseases 20 20233321
2022 Chemoresistance Transmission via Exosome-Transferred MMP14 in Pancreatic Cancer. Frontiers in oncology 19 35223528
2014 Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix. Journal of cell science 19 24463815