Affinage

MMP1

Interstitial collagenase · UniProt P03956

Round 2 corrected
Length
469 aa
Mass
54.0 kDa
Annotated
2026-04-28
130 papers in source corpus 40 papers cited in narrative 39 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP1 (interstitial collagenase) is a secreted zinc-dependent endopeptidase that initiates degradation of fibrillar collagens (types I, II, III) and cleaves additional extracellular substrates including IGFBP-3, MCP chemokines, LAMA5, and EGF-like ligands (AREG, HB-EGF, TGFα), thereby modulating IGF bioavailability, chemokine signaling, angiogenesis, and osteoclastogenesis (PMID:10419448, PMID:7523391, PMID:10947989, PMID:27324842, PMID:19608765). MMP1 also functions as a protease agonist of PAR1, generating intracellular Ca²⁺ signals that drive tumor cell migration, invasion, and fibroblast senescence in the tumor microenvironment (PMID:15707890, PMID:33684534). The proenzyme is activated extracellularly by mast cell chymase (Leu83–Thr84 cleavage) and MMP-7 (Gln80–Phe81 cleavage), and its catalytic domain—containing a catalytic zinc, structural zinc, and calcium—uses an exon-5-encoded loop to confer collagen substrate specificity (PMID:8027075, PMID:7896811, PMID:8278810, PMID:11248710). MMP1 transcription is induced by AP-1 (c-Fos/c-Jun), NF-κB, C/EBP-β, ETS1/2, EGR-1, ETV4, and RUNX2 downstream of cytokines, UV-induced DNA damage, and ERK/JNK signaling, and is post-transcriptionally regulated by miR-526b and NAT10-mediated ac4C mRNA modification (PMID:3037355, PMID:17921324, PMID:32317080, PMID:29251790, PMID:26292968, PMID:37705232).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 1986 High

    Cloning and sequence determination of MMP1 established it as a preproenzyme with a signal peptide and an 81-residue propeptide removed during activation, providing the molecular framework for understanding zymogen processing.

    Evidence cDNA cloning and full-length sequencing of human skin fibroblast collagenase mRNA

    PMID:3009463

    Open questions at the time
    • Activation mechanism (which proteases cleave the propeptide) was not yet identified
    • Three-dimensional structure unknown
  2. 1986 High

    Identification of a TPA-inducible 32-bp enhancer element in the MMP1 promoter revealed that MMP1 is transcriptionally regulated by phorbol ester signaling, founding the study of MMP1 transcriptional control.

    Evidence Deletion mutagenesis of the MMP1 5′-flanking region with transfection reporter assays

    PMID:3037355

    Open questions at the time
    • Transcription factors binding this element were not identified
    • Physiological inducers beyond TPA not yet explored
  3. 1994 High

    Crystal structure determination of the MMP1 catalytic domain revealed the catalytic zinc, structural zinc, and calcium ion, and showed a thermolysin/astacin-like fold, providing the structural basis for inhibitor design and understanding catalytic mechanism.

    Evidence X-ray crystallography at 2.4 Å of inhibitor-bound MMP1 catalytic domain

    PMID:8278810

    Open questions at the time
    • Full-length structure with hemopexin domain not determined
    • Structural basis for collagen specificity not resolved at this stage
  4. 1994 High

    Identification of mast cell chymase and subsequently MMP-7 as physiological activators of pro-MMP1, with precise cleavage sites mapped, resolved how the zymogen is processed extracellularly and revealed cascade activation among MMPs.

    Evidence In vitro activation assays with purified chymase and MMP-7, N-terminal sequencing of cleavage products

    PMID:7896811 PMID:8027075

    Open questions at the time
    • In vivo relevance of each activation pathway in specific tissues not established
    • Whether other proteases contribute to activation in inflammatory contexts
  5. 1994 High

    Demonstration that MMP1 cleaves IGFBP-3 expanded its substrate repertoire beyond collagens and implicated MMP1 in growth factor bioavailability regulation.

    Evidence Reconstituted in vitro cleavage with recombinant enzymes and N-terminal sequencing of cleavage products

    PMID:7523391

    Open questions at the time
    • In vivo significance for IGF signaling not confirmed
    • Other IGFBP family members as substrates not tested
  6. 2000 High

    Discovery that MMP1 cleaves MCP-3 to generate CC chemokine receptor antagonists revealed an anti-inflammatory function, showing MMP1 shapes immune cell recruitment beyond simple ECM remodeling.

    Evidence In vitro cleavage of recombinant chemokines by multiple MMPs, receptor-binding and chemotaxis assays, in vivo paw-edema model

    PMID:10947989 PMID:12149192

    Open questions at the time
    • Relative importance of MMP1 vs other collagenases for in vivo chemokine processing unclear
    • Whether MMP1 cleaves other chemokine families not tested
  7. 2001 High

    Exon-5 domain swap experiments established that the exon-5-encoded loop is the structural determinant of MMP1's collagenolytic specificity and TIMP selectivity, answering why MMP1 but not MMP-3 cleaves fibrillar collagens.

    Evidence MMP-1/MMP-3 chimeric enzymes tested on type I collagen, synthetic substrates, and TIMPs

    PMID:11248710

    Open questions at the time
    • Atomic-resolution mechanism of collagen unwinding by the hemopexin domain not resolved
    • Whether exon-5 alone is sufficient for collagenolytic activity on type II/III collagens not tested
  8. 2005 High

    MMP1 was identified as a protease agonist of PAR1, establishing a non-ECM signaling function whereby MMP1-mediated PAR1 cleavage triggers Ca²⁺ signals that drive breast carcinoma invasion—a paradigm shift from purely ECM-degrading roles.

    Evidence PAR1 cleavage assays, Ca²⁺ signaling, migration assays, and breast cancer xenograft model

    PMID:15707890

    Open questions at the time
    • Precise PAR1 cleavage site by MMP1 vs thrombin-mediated activation and downstream signal divergence not fully resolved
    • Whether PAR1 activation by MMP1 occurs in non-cancer physiological contexts
  9. 2005 High

    Cdc42 was placed as an upstream negative regulator of MMP1 via ERK suppression, establishing that Rho-family GTPases control MMP1 expression through MAPK pathways in fibroblasts and keratinocytes.

    Evidence Cdc42 siRNA with rescue, Rac1 co-silencing, MEK/ERK inhibitors in dermal fibroblasts; later confirmed in collagen-stimulated keratinocytes

    PMID:15728253 PMID:24352036

    Open questions at the time
    • Direct Cdc42 targets upstream of ERK not identified
    • Whether Cdc42-MMP1 axis operates in vivo tissue remodeling unknown
  10. 2006 High

    Drosophila genetic epistasis showed that Mmp1 is the critical JNK/Fos effector of polarity-loss-driven invasion in cooperative tumors, providing in vivo genetic validation of MMP1 as a tumor invasion executor.

    Evidence mmp1 RNAi, TIMP overexpression in Drosophila imaginal disc clones with scribble/Ras tumors

    PMID:17082773

    Open questions at the time
    • Direct mammalian ortholog relevance of this Drosophila JNK-Mmp1 pathway not validated
    • Mmp1 substrates in Drosophila invasion not identified in this study
  11. 2007 High

    Combined MMP1/MMP2 loss-of-function in breast cancer xenografts demonstrated that MMP1 is required for intravasation, extravasation, and lung metastasis seeding, defining MMP1 as a rate-limiting protease for the metastatic cascade.

    Evidence Genetic knockdown and pharmacological inhibition of MMP1/MMP2 in breast cancer xenograft and lung metastasis models

    PMID:17429393

    Open questions at the time
    • Individual contributions of MMP1 vs MMP2 to each metastatic step not fully separated
    • Host-derived vs tumor-derived MMP1 contributions unclear
  12. 2007 High

    Mapping the transcriptional cascade upstream of MMP1 in cardiac fibroblasts showed that IL-17 induces MMP1 through p38/ERK → AP-1 + NF-κB + C/EBP-β, establishing multi-transcription-factor convergence as the mechanism for cytokine-driven MMP1 induction.

    Evidence siRNA, antisense, dominant-negatives, pharmacological kinase inhibitors, EMSA, and reporter assays in primary cardiac fibroblasts

    PMID:17921324

    Open questions at the time
    • Relative quantitative contribution of each transcription factor to total MMP1 output not determined
    • Whether this multi-factor module applies identically in other cell types
  13. 2008 High

    UV-induced DNA damage in keratinocytes was identified as the primary trigger for paracrine MMP1 induction in the dermis, establishing an epidermis-to-dermis signaling pathway for photoaging-associated collagen degradation.

    Evidence DNA repair enzyme (photolyase) application to UV-irradiated keratinocytes, conditioned medium transfer to fibroblasts

    PMID:18459971

    Open questions at the time
    • Identity of the soluble paracrine mediator from keratinocytes not determined
    • In vivo relevance beyond ex vivo skin models not confirmed
  14. 2009 High

    MMP1 was shown to release membrane-tethered EGF-like ligands (AREG, HB-EGF, TGFα) from tumor cell surfaces, activating osteoblast EGFR to suppress OPG and drive osteolytic bone metastasis—establishing MMP1 as a sheddase with paracrine signaling consequences.

    Evidence siRNA knockdown of MMP1/ADAMTS1, EGFR inhibitors, EGF-like ligand release assays, osteoclast differentiation assays, in vivo bone metastasis models

    PMID:19608765

    Open questions at the time
    • Whether MMP1 directly cleaves all three EGF-like ligands or acts via intermediate proteases
    • Relative contribution of MMP1 vs ADAMTS1 to ligand shedding
  15. 2014 High

    MMP1 was identified as a required effector of shear-stress-induced endothelial sprouting, linking hemodynamic forces to angiogenesis through MMP1 upregulation.

    Evidence Microfluidic shear stress devices with siRNA knockdown of MMP1 and 3D sprouting assays

    PMID:24843171

    Open questions at the time
    • Mechanotransduction pathway connecting shear stress to MMP1 transcription not identified
    • Relevant MMP1 substrates in sprouting angiogenesis not defined
  16. 2015 High

    Post-transcriptional regulation of MMP1 was established by miR-203 (via NF-κB) and miR-526b (direct 3′UTR targeting), expanding the regulatory landscape beyond transcriptional control.

    Evidence miR-203 overexpression with NF-κB inhibition in RA fibroblasts; 3′UTR luciferase reporter mutagenesis for miR-526b

    PMID:21279994 PMID:26292968

    Open questions at the time
    • Whether miR-203 directly targets MMP1 3′UTR or acts indirectly via NF-κB pathway modulation
    • In vivo relevance of miR-526b regulation not established
  17. 2016 High

    Identification of LAMA5 as an MMP1 substrate whose proteolytic fragments promote angiogenesis via integrin αvβ3 defined a novel extracellular signaling axis connecting MMP1-mediated ECM cleavage to vascular growth.

    Evidence Mass spectrometry substrate identification, integrin αvβ3 blocking antibody, MMP1 siRNA with xenograft tumor volume measurement

    PMID:27324842

    Open questions at the time
    • Specific LAMA5 cleavage sites not mapped
    • Whether other laminin subunits are also MMP1 substrates
  18. 2017 Medium

    EV-packaged MMP1 mRNA from metastatic ovarian cancer cells was shown to induce mesothelial cell apoptosis, revealing a non-canonical mechanism of MMP1 delivery for peritoneal metastasis.

    Evidence EV transcriptome analysis, qRT-PCR of MMP1 mRNA in EVs, in vitro apoptosis assays, in vivo peritoneal dissemination model

    PMID:28262727

    Open questions at the time
    • Whether EV-delivered MMP1 mRNA is translated into functional protein in recipient cells not directly shown
    • Mechanism of selective MMP1 mRNA packaging into EVs unknown
    • Single-lab finding not independently replicated
  19. 2018 High

    The CIC–ETV4–MMP1 axis was established in hepatocellular carcinoma: CIC suppresses ETV4, which directly transactivates MMP1, and MMP1 knockdown fully rescues CIC-deficiency phenotypes, placing MMP1 as the terminal effector of this invasion-driving cascade.

    Evidence Epistatic knockdown/overexpression of CIC, ETV4, and MMP1 with luciferase reporter assays and in vivo xenograft

    PMID:29251790

    Open questions at the time
    • Whether CIC–ETV4–MMP1 axis operates in non-HCC cancers
    • Direct ETV4 binding sites on MMP1 promoter not mapped by ChIP in this study
  20. 2021 High

    MMP1 was shown to induce premature senescence in pulmonary fibroblasts through PAR-1 and oxidative stress, and senescent fibroblasts reciprocally promoted tumor growth, establishing MMP1 as a remodeler of the tumor microenvironment beyond direct ECM degradation.

    Evidence MMP1 overexpression/knockdown, co-culture senescence assays, PAR-1 inhibition, oxidative stress measurement, in vivo mouse models

    PMID:33684534

    Open questions at the time
    • Specific PAR-1 downstream signaling events leading to senescence not fully mapped
    • Whether this senescence-inducing function operates in non-pulmonary tissue stroma
  21. 2021 Medium

    A positive feedback loop (MMP1/PAR1/ERK/ETV4/MMP1) was identified in tumor-associated macrophage–colon cancer cell communication, where TAM-derived MMP1 activates PAR1 to drive cell cycle progression and ETV4 feeds back to sustain MMP1 transcription.

    Evidence Exogenous MMP1, PAR-1/MEK inhibitors, ChIP for ETV4 at MMP1 promoter, cell cycle analysis, in vivo experiments

    PMID:34753916

    Open questions at the time
    • Quantitative contribution of the feedback loop vs unidirectional signaling not measured
    • Single-lab study; independent replication needed
    • Whether loop operates in non-colon cancer contexts
  22. 2022 Medium

    NAT10-mediated ac4C modification of MMP1 mRNA was identified as a post-transcriptional stabilization mechanism promoting OSCC invasion, revealing epitranscriptomic control of MMP1 expression.

    Evidence NAT10 knockdown, acRIP-seq, MMP1 mRNA stability assays, MMP1 overexpression rescue, xenograft experiments

    PMID:37705232

    Open questions at the time
    • Specific ac4C sites on MMP1 mRNA not mapped at nucleotide resolution
    • Whether other epitranscriptomic modifications regulate MMP1 mRNA
    • Single-lab finding not independently confirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the paracrine factor mediating UV-keratinocyte-to-fibroblast MMP1 induction, the structural mechanism by which the hemopexin domain cooperates with the catalytic domain to unwind triple-helical collagen, and whether the EV-mediated MMP1 mRNA transfer mechanism generalizes across cancer types.
  • No full-length MMP1 structure with collagen substrate
  • Paracrine UV mediator unidentified
  • EV-mediated MMP1 mRNA transfer lacks independent replication

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 10 GO:0016787 hydrolase activity 3
Localization
GO:0005576 extracellular region 6 GO:0031012 extracellular matrix 2 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-168256 Immune System 1
Partners
ETV4IGFBP3LAMA5MMP7PAR1TIMP1TIMP2

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1986 MMP1 (human fibroblast collagenase) is synthesized as a preproenzyme (Mr 54,092) with a 19-amino-acid signal peptide; proteolytic activation removes 81 amino-terminal residues, yielding the active enzyme; the sequence is homologous to an oncogene-induced rat protein. cDNA cloning and sequence analysis of human skin collagenase mRNA The Journal of biological chemistry High 3009463
1986 The MMP1 (collagenase) gene contains a 32-bp 5'-flanking element (positions −73 to −42) that functions as a phorbol-ester (TPA)-inducible enhancer, acting in a position- and orientation-independent manner to drive transcription. 5' and 3' deletion mutagenesis of the MMP1 promoter region followed by transfection into human/murine cells Molecular and cellular biology High 3037355
1994 The crystal structure of the MMP1 catalytic domain complexed with an inhibitor at 2.4 Å resolution revealed a catalytic zinc ion, a second structural zinc ion, and a calcium ion critical for tertiary structure stability; the fold is homologous to thermolysin and astacin despite low sequence homology. X-ray crystallography of inhibitor-bound MMP1 catalytic domain Science High 8278810
1994 MMP1 (along with MMP-3) degrades insulin-like growth factor-binding protein-3 (IGFBP-3) in vitro, cleaving within the mid-region of the binding protein, suggesting a role for MMP1 in modulating IGF bioavailability. Immunoaffinity depletion of MMPs from conditioned medium, in vitro cleavage assays with purified recombinant enzymes, and N-terminal sequencing of cleavage products The Journal of biological chemistry High 7523391
1994 Human skin mast cell chymase directly activates interstitial procollagenase (pro-MMP1) by cleaving the Leu83–Thr84 bond in a single step, without intermediate species; heparin accelerates this activation and prevents further degradation of active MMP1. In vitro activation assays with purified human chymase and procollagenase, N-terminal sequencing of activation products, time- and concentration-dependence measurements The Journal of biological chemistry High 8027075
1995 MMP-7 (matrilysin) activates pro-MMP1 by cleaving the Gln80–Phe81 bond, an activity enhanced ~6.5-fold in the presence of APMA, revealing a cascade activation mechanism among MMPs. In vitro activation assays with purified MMP-7 and pro-MMP1, N-terminal sequencing The Journal of biological chemistry High 7896811
1999 MMP1 is a zinc-dependent endopeptidase and the most ubiquitously expressed interstitial collagenase; it is the primary enzyme responsible for initial cleavage of fibrillar collagens (especially types I, II, III) within the extracellular matrix. Its activity is controlled transcriptionally, by zymogen activation, and by TIMPs. Comprehensive review/biochemical characterization collating structural, enzymatic, and inhibitor data The Journal of biological chemistry High 10419448
2000 MMP1, MMP-13, and other collagenases (but not MMP-7, MMP-8, or MMP-9) cleave monocyte chemoattractant protein-3 (MCP-3) between residues 4 and 5, generating antagonists of CC chemokine receptors CCR-1, -2, and -3 that inhibit chemotaxis and reduce inflammation in vivo. In vitro cleavage of recombinant chemokines by 8 recombinant MMPs, receptor-binding assays, transwell migration assays, in vivo carrageenan paw-edema model Science / Blood High 10947989 12149192
2001 The region of MMP1 encoded by exon 5 determines substrate specificity (collagenolytic activity) and inhibitor selectivity: a chimeric enzyme with MMP-3's exon-5 region substituted for MMP-1's retained only ~2.2% of wild-type collagenolytic activity against type I collagen and displayed MMP-3-like kinetics on synthetic substrates and with TIMP-2. Chimeric enzyme construction (exon-5 swap between MMP-1 and MMP-3), in vitro collagen cleavage assays, synthetic substrate kinetics, TIMP inhibition assays European journal of biochemistry High 11248710
2005 MMP-1 functions as a protease agonist of PAR1 (protease-activated receptor-1): MMP-1 derived from stromal fibroblasts cleaves PAR1 at the correct site to generate PAR1-dependent Ca2+ signals and promotes breast carcinoma cell migration and invasion in a xenograft model. Xenograft tumor model, PAR1 expression/knockdown, Ca2+ signaling assays, migration assays, MMP-1 activity assays Cell High 15707890
2006 In Drosophila, JNK signaling resulting from loss of the polarity gene scribble promotes tumor cell invasiveness through Fos-dependent transcriptional activation of mmp1 downstream of JNK; TIMP expression or Mmp1 RNAi knockdown suppresses invasion, placing Mmp1 as the effector of JNK-driven invasion in a Ras-cooperative tumor context. Genetic epistasis in Drosophila imaginal disc clones: RNAi knockdown of mmp1, TIMP overexpression, loss-of-function/gain-of-function of JNK/Ras pathway components, invasion assays The EMBO journal High 17082773
2007 MMP1 and MMP-2 together facilitate the release of circulating tumor cells into the bloodstream and their extravasation into the lung to seed pulmonary metastasis; MMP1 (expressed in human breast cancer cells) is required for tumor blood-vessel assembly and breaching of lung capillaries. Genetic knockdown and pharmacological inhibition of MMP1/MMP2 in breast cancer xenograft and lung metastasis models; angiogenesis assays Nature High 17429393
2008 UV-induced DNA damage in epidermal keratinocytes is a primary trigger for MMP-1 induction in both the epidermis and dermis: photolyase-mediated repair of UV-induced DNA lesions in keratinocytes reduced MMP-1 mRNA and protein in skin, and conditioned medium from UV-irradiated keratinocytes induced MMP-1 in unirradiated fibroblasts through soluble mediators; DNA-repair enzyme pretreatment of keratinocytes blocked this paracrine MMP-1 induction. Liposome-encapsulated DNA repair enzymes applied to human skin ex vivo; conditioned medium transfer experiments between irradiated keratinocytes and unirradiated fibroblasts; MMP-1 mRNA/protein measurement Experimental dermatology High 18459971
2008 Met receptor tyrosine kinase phosphorylates MUC1 cytoplasmic tail at the YHPM tyrosine; phosphorylated MUC1CT translocates to the nucleus, enhances its interaction with p53, which suppresses AP-1 transcription factor activity at the MMP1 promoter, thereby reducing MMP1 transcription and HGF-induced cancer cell invasiveness. Co-IP, real-time confocal imaging of nuclear MUC1CT localization, kinase assays, AP-1 reporter assays, promoter-interaction studies, invasion assays The Journal of biological chemistry High 18625714
2008 Akt blockade in human dermal fibroblasts upregulates MMP1 production and reverses TGF-β-mediated MMP1 suppression, while simultaneously reducing type I collagen; this dual profibrotic role of Akt (increasing collagen and decreasing MMP1-mediated degradation) is exacerbated in systemic sclerosis fibroblasts. Pharmacological Akt inhibitors, siRNA knockdown, dominant-negative Akt mutant; Western blot for collagen and MMP1; SSc fibroblast comparison The Journal of investigative dermatology High 18323784
2009 ADAMTS1 and MMP1, expressed by tumor cells, orchestrate a paracrine signaling cascade in bone metastasis: both metalloproteinases proteolytically release membrane-bound EGF-like ligands (AREG, HB-EGF, TGFα) from tumor cells, which then suppress osteoprotegerin (OPG) in osteoblasts via EGFR, thereby potentiating osteoclast differentiation and osteolytic bone metastasis. In vitro and in vivo bone metastasis models, siRNA knockdown of MMP1/ADAMTS1, EGFR inhibitors, EGF-like ligand release assays, osteoclast differentiation assays Genes & development High 19608765
2005 Cdc42 downregulates MMP-1 expression in human skin fibroblasts by suppressing the ERK1/2 pathway: Cdc42 siRNA silencing caused a 15-fold increase in MMP-1 secretion that was dependent on ERK1/2 (but not p38 or RhoA-ROCK), and was partially reduced by co-silencing Rac1, placing Cdc42 upstream of Rac1 and ERK1/2 in the regulation of MMP-1. siRNA silencing of Cdc42, RhoA, and Rac1; rescue with wild-type Cdc42; chemical kinase inhibitors; ERK1/2 and p38 phosphorylation assays; MMP-1 mRNA and secretion measurement Journal of cell science High 15728253
2005 EPA inhibits UV-induced MMP-1 expression in human dermal fibroblasts by blocking activation of MEK1/ERK and SEK1/JNK kinases, thereby reducing c-Fos expression and c-Jun phosphorylation and suppressing AP-1 DNA binding activity; this effect is independent of antioxidant activity. In vitro UV irradiation of fibroblasts with EPA pretreatment; kinase inhibitors; AP-1 EMSA; c-Fos/c-Jun Western blots; MMP-1 mRNA/protein measurement Journal of lipid research High 15930517
2007 IL-17 induces MMP-1 expression in primary human cardiac fibroblasts through p38 MAPK- and ERK1/2-dependent activation of AP-1 (c-Fos, c-Jun, Fra-1), NF-κB (p50/p65), and C/EBP-β; inhibiting any of these transcription factors attenuates MMP-1 expression. siRNA knockdown, antisense oligonucleotides, dominant-negative expression vectors, pharmacological kinase inhibitors (SB-203580, PD-98059), EMSA, reporter assays, Northern blot, ELISA American journal of physiology. Heart and circulatory physiology High 17921324
2010 Akt inhibition upregulates MMP1 in human dermal fibroblasts through a CCN2 (CTGF)-dependent pathway: Akt blockade induces CCN2 expression, which in turn activates ERK1/2 and Ets1 phosphorylation, leading to MMP1 transcription; ERK1/2 inhibition abolishes CCN2-driven MMP1 induction. Pharmacological Akt inhibitor, Akt siRNA, CCN2 siRNA, ERK1/2 inhibitor (UO126), Western blotting for phospho-ERK1/2 and phospho-Ets1, MMP1 protein/mRNA measurement Experimental dermatology High 20201953
2011 MMP1 promoter polymorphism (identified by ChIP) creates binding sites for transcription factors ETS1, ETS2, and GATA3; the allelic variant that accommodates these transcription factor binding events drives bimodal MMP1 mRNA expression across individuals in endothelial cells both at baseline and in response to inflammatory mediators. Hierarchical clustering of microarray data from 15 HUVEC individuals, RT-PCR validation, MMP1 activity assays, DNA sequencing of 69 individuals, chromatin immunoprecipitation (ChIP) for ETS1/ETS2/GATA3 BMC genomics Medium 21244711
2013 Cdc42 negatively regulates MMP-1 expression in collagen-activated human keratinocytes by suppressing ERK activity; contact with type I collagen via α2β1 integrin activates ERK (but not JNK or p38), and ERK inhibition blocks collagen-stimulated MMP-1 expression and keratinocyte migration on collagen. ERK, p38, and JNK pharmacological inhibitors; Cdc42 activity analysis; MMP-1 mRNA/protein in primary neonatal and adult keratinocytes stimulated with type I collagen The Journal of investigative dermatology High 24352036
2014 Fluid shear stress above a threshold (~10 dyn/cm²) triggers endothelial cell sprouting (angiogenesis) through upregulation of MMP1; siRNA-mediated MMP1 knockdown abrogates flow-induced sprouting, establishing MMP1 as a required downstream effector of shear-stress-driven angiogenesis. Microfluidic shear stress devices, siRNA knockdown of MMP1, sprouting/invasion assays in 3D matrix Proceedings of the National Academy of Sciences of the United States of America High 24843171
2015 In Drosophila metamorphosis, Mmp1 preferentially cleaves DE-cadherin-mediated cell–cell junctions (while Mmp2 degrades basement membrane), and cooperative action of both MMPs is required for complete fat body tissue dissociation into individual cells. Fat body-specific RNAi screen in Drosophila, biochemical substrate assays, genetic interaction experiments, cellular imaging Scientific reports High 25520167
2015 miR-203 overexpression in rheumatoid arthritis synovial fibroblasts leads to increased secretion of MMP-1 and IL-6 via the NF-κB pathway; DNA demethylation (5-azaC) increases miR-203 expression, identifying methylation-dependent epigenetic regulation as a mechanism controlling MMP-1 levels in RA fibroblasts. miR-203 precursor transfection in RASFs, NF-κB pathway inhibition (SC-514), real-time PCR, ELISA for MMP-1 and IL-6, 5-azaC treatment Arthritis and rheumatism High 21279994
2015 miR-526b directly targets the 377–383 region of the MMP1 3' UTR to suppress MMP1 mRNA expression; reporter constructs with mutated 3'UTR abolished this regulation, and miR-526b and MMP1 mRNA show inverse expression between adult dermal and neonatal fibroblasts. 3'UTR luciferase reporter assays with wild-type and mutant MMP1 3'UTR, miR-526b overexpression, RT-PCR in dermal/neonatal fibroblasts Experimental & molecular medicine Medium 26292968
2016 MMP1 secreted by transformed (H-Ras-oncogenic) epithelial cells cleaves laminin subunit alpha-5 (LAMA5), generating proteolytic fragments that promote endothelial cell angiogenesis via integrin αvβ3; MMP1 knockdown reduces tumor invasion, anchorage-independent growth, and xenograft tumor volume, and diminishes the angiogenic potency of the secretome. MMP1 siRNA knockdown in 21D1 cells, in vivo xenograft, secretome transfer to fibroblasts/endothelial cells, angiogenesis assays, integrin αvβ3 antibody inhibition, mass spectrometry identification of LAMA5 as MMP1 substrate Scientific reports High 27324842
2016 The DDR2–AP-1–CYR61–ETS1–MMP1 signaling loop in fibroblast-like synoviocytes (FLS) mediates collagen II-induced bone erosion in rheumatoid arthritis: collagen II activates DDR2 phosphorylation → AP-1 → CYR61 expression → ETS1-driven MMP1 production → FLS invasion and migration; adenoviral CYR61 shRNA in vivo reduces arthritis severity and bone erosion. siRNA/shRNA knockdown, adenoviral shRNA in vivo (CIA rat model), micro-CT, AP-1 ChIP, co-IP, FLS invasion/migration assays Journal of bone and mineral research High 27653023
2017 Slug (SNAI2) directly binds three E-box/Slug-binding sites in the MMP1 promoter to enhance MMP1 transcription in breast cancer cells with multi-drug resistance; ChIP-qPCR and dual luciferase assays confirmed direct promoter binding, and MMP1 overexpression reduced drug sensitivity while MMP1 knockdown enhanced sensitivity in MDR cells. Dual luciferase assays with MMP1 promoter constructs, ChIP-qPCR, Slug overexpression/knockdown, MMP1 overexpression/knockdown, drug sensitivity assays PloS one High 28334049
2018 The transcriptional repressor Capicua (CIC) suppresses HCC progression by repressing ETV4 expression; ETV4 in turn directly drives MMP1 expression in HCC cells, and MMP1 knockdown completely blocks the proliferation and invasion phenotype caused by CIC deficiency, establishing a CIC–ETV4–MMP1 regulatory axis. CIC overexpression/knockdown in vitro and in vivo, ETV4 and MMP1 knockdown, proliferation/invasion assays, luciferase reporter assays Hepatology High 29251790
2018 FICZ (an endogenous AHR ligand) upregulates MMP1 expression in normal human dermal fibroblasts through AHR-dependent MEK/ERK signaling; AHR knockdown and MEK/ERK inhibitors block FICZ-induced MMP1 upregulation, while JNK/p38 inhibitors are additionally required for UVB-induced MMP1. AHR-knockdown NHDFs, selective MAPK inhibitors, MEK/ERK phosphorylation (Western blot), ELISA, qRT-PCR Journal of dermatological science High 29703420
2018 Gasdermin C (GSDMC), induced by UV irradiation at late time points, is required for UV-induced MMP-1 expression (but not MMP-3 or MMP-9) in human skin keratinocytes; GSDMC overexpression increases ERK and JNK activation, and inhibition of ERK or JNK suppresses GSDMC-induced MMP-1 expression. GSDMC knockdown and overexpression in HaCaT and primary keratinocytes, ERK/JNK inhibitors, qRT-PCR, Western blot Journal of dermatological science Medium 29428815
2019 ETV4 directly activates MMP1 transcription in NSCLC cells; ETV4 overexpression increases MMP1 mRNA and protein, and luciferase reporter assays confirm direct ETV4 regulation of the MMP1 promoter; inhibition of MMP1 partially abolishes ETV4-driven cell proliferation and migration. ETV4 gain/loss-of-function, microarray, luciferase reporter assays, MMP1 knockdown rescue experiments, in vivo xenograft Molecular carcinogenesis Medium 31670855
2020 EGR-1 (early growth response protein 1) directly binds to an EGR-1 binding sequence (EBS) in the proximal MMP1 promoter and transactivates MMP1 in response to TNFα in keratinocytes; EGR-1 silencing reduces TNFα-induced MMP-1 expression, and mutation of the EBS abolishes EGR-1-mediated promoter activation. All three MAPKs (ERK1/2, JNK, p38) mediate TNFα-induced MMP-1 via EGR-1 upregulation. Promoter deletion analysis, luciferase reporter assays, EGR-1 siRNA, EGR-1 overexpression, EBS site-directed mutagenesis, MAPK inhibitors, Western blot BMB reports High 32317080
2021 MMP1 secreted by LCC tumor cells induces premature senescence in pulmonary fibroblasts (via PAR-1 and oxidative stress), and senescent fibroblasts in turn drive LCC cell growth and invasion; MMP1 knockdown prevents fibroblast senescence and tumor promotion in cell culture and mouse models, and MMP1 combined with TGF-β1 is sufficient to induce fibroblast senescence. MMP1 overexpression/knockdown in LCC cell lines, co-culture senescence assays, in vivo mouse models, PAR-1 inhibition, oxidative stress assays Cancer letters High 33684534
2021 TAM-derived MMP1 activates PAR-1 on colon cancer cells to trigger MAPK/Erk signaling, accelerating cell cycle progression (G0/G1 to S and G2/M) and activating cdc25a/CDK4-cyclin D1 and p21/cdc2-cyclin B1 complexes via c-Myc and ETV4; ETV4 in turn binds the MMP1 promoter to form a positive feedback loop (MMP1/PAR1/Erk1/2/ETV4/MMP1). Exogenous MMP1 treatment, PAR-1 inhibition, MEK/ERK inhibitors, cell cycle analysis, co-IP, ChIP for ETV4 at MMP1 promoter, in vitro/in vivo experiments Cell death discovery Medium 34753916
2022 RUNX2 directly binds to specific motifs in the MMP1 promoter and activates MMP1 transcription in triple-negative breast cancer, as confirmed by ChIP and qRT-PCR; RUNX2 silencing suppresses MMP1 expression and reduces proliferation, migration, invasion, chemoresistance, and in vivo tumorigenicity. RUNX2 siRNA knockdown, RNA-sequencing, ChIP assay at MMP1 promoter, qRT-PCR, in vivo xenograft tumorigenicity Frontiers in oncology Medium 36483054
2022 NAT10 promotes MMP1 mRNA stability through N4-acetylcytidine (ac4C) acetylation of MMP1 mRNA; NAT10 knockdown reduces both total and ac4C-acetylated MMP1 mRNA and decreases MMP1 mRNA stability, impairing OSCC cell proliferation, migration, invasion, and in vivo tumorigenesis in an MMP1-dependent manner. NAT10 knockdown (lentivirus), acRIP (acetylated RNA immunoprecipitation sequencing), MMP1 mRNA stability assays, xenograft experiments, rescue by MMP1 overexpression Cancer science Medium 37705232
2017 MMP1 mRNA is selectively packaged into cancer-derived extracellular vesicles (EVs) from highly metastatic ovarian cancer cells; EV transfer delivers intact MMP1 mRNA to mesothelial cells, upregulating MMP1 expression, inducing apoptosis in mesothelial cells, and facilitating destruction of the peritoneal barrier for peritoneal dissemination. Whole transcriptome analysis, EV isolation and characterization, MMP1 mRNA detection in EVs by qRT-PCR, in vitro apoptosis assays, in vivo peritoneal dissemination model, MMP1 mRNA detection in patient ascites EVs Nature communications Medium 28262727

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Matrix metalloproteinases. The Journal of biological chemistry 3561 10419448
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1996 Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. The Journal of clinical investigation 826 8609233
1987 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Molecular and cellular biology 745 3037355
2005 PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 664 15707890
1986 Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein. The Journal of biological chemistry 663 3009463
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1998 Matrix metalloproteinases: structures, evolution, and diversification. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 612 9737711
2000 Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science (New York, N.Y.) 609 10947989
2001 Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. The Journal of cell biology 599 11381077
2007 Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 554 17429393
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
2008 MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS medicine 472 18447576
1986 Comparison of human stromelysin and collagenase by cloning and sequence analysis. The Biochemical journal 455 3030290
2002 Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood 454 12149192
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2005 Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS medicine 406 16128620
1993 Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. The Journal of biological chemistry 372 8226919
2003 Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. Cancer letters 336 12706853
2006 JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. The EMBO journal 332 17082773
1999 Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. The Journal of biological chemistry 326 10224132
2003 Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. The Journal of biological chemistry 320 12904296
2015 Matrix remodeling by MMPs during wound repair. Matrix biology : journal of the International Society for Matrix Biology 314 25770908
2014 Fluid shear stress threshold regulates angiogenic sprouting. Proceedings of the National Academy of Sciences of the United States of America 302 24843171
1994 Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science (New York, N.Y.) 278 8278810
1994 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. The Journal of biological chemistry 269 7523391
1999 Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. The Journal of biological chemistry 268 9920899
2011 Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis and rheumatism 262 21279994
1994 Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. The Journal of biological chemistry 260 8027075
2017 Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. Nature communications 259 28262727
1995 Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties. The Journal of biological chemistry 257 7896811
2009 ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes & development 247 19608765
2007 IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation. American journal of physiology. Heart and circulatory physiology 214 17921324
2021 Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR. Theranostics 146 33391541
2008 UV-induced DNA damage initiates release of MMP-1 in human skin. Experimental dermatology 145 18459971
2015 High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis. Genetics and molecular research : GMR 133 26600542
2016 MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma. Cancer letters 96 27130665
2006 Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2, MMP-1, and MMP-9 expression. Molecular therapy : the journal of the American Society of Gene Therapy 84 16455304
2000 Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. Investigative ophthalmology & visual science 84 10670469
2005 Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts. Journal of lipid research 79 15930517
2008 Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. The Journal of biological chemistry 78 18625714
2018 Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4-MMP1 axis. Hepatology (Baltimore, Md.) 76 29251790
2009 Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford, England) 74 19056796
2008 Treatment of childhood T-cell lymphoblastic lymphoma according to the strategy for acute lymphoblastic leukaemia, without radiotherapy: long term results of the EORTC CLG 58881 trial. European journal of cancer (Oxford, England : 1990) 71 18342502
2003 Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 66 12873541
2008 Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. The Journal of investigative dermatology 64 18323784
2014 Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles. Scientific reports 62 25520167
2009 MMP-1 polymorphism and its relationship to pathological processes. Journal of biosciences 60 19550047
2008 Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. BMC cancer 59 18366705
2020 TCONS_00012883 promotes proliferation and metastasis via DDX3/YY1/MMP1/PI3K-AKT axis in colorectal cancer. Clinical and translational medicine 58 33135346
2019 ETV4 overexpression promotes progression of non-small cell lung cancer by upregulating PXN and MMP1 transcriptionally. Molecular carcinogenesis 57 31670855
2005 Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway. Journal of cell science 57 15728253
2019 Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxidative medicine and cellular longevity 53 30800206
2017 MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer. PloS one 53 28334049
2010 Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma. Investigative ophthalmology & visual science 52 20089870
2021 MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. Cancer letters 50 33684534
2008 Expression of MMP-1 in cartilage and synovium of experimentally induced rabbit ACLT traumatic osteoarthritis: immunohistochemical study. Rheumatology international 50 18597092
2002 Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells. Matrix biology : journal of the International Society for Matrix Biology 50 12009332
2001 The clinical significance of MMP-1 expression in oesophageal carcinoma. British journal of cancer 49 11161388
2007 Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. Journal of biomedical materials research. Part B, Applied biomaterials 48 16862557
2018 Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways. Journal of dermatological science 44 29428815
2011 ERK/MAPK pathways play critical roles in EGFR ligands-induced MMP1 expression. Biochemical and biophysical research communications 44 21440529
2013 Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells. Mediators of inflammation 43 24058270
2022 CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling. International journal of molecular sciences 42 35163100
2017 Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. PloS one 42 28961241
2005 TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 42 16459052
2019 MicroRNA hsa-miR-623 directly suppresses MMP1 and attenuates IL-8-induced metastasis in pancreatic cancer. International journal of oncology 41 31115512
2021 Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role. Cell death discovery 38 34753916
2016 Kynurenine Modulates MMP-1 and Type-I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts. Journal of cellular physiology 35 26992058
2022 HPRT1 Promotes Chemoresistance in Oral Squamous Cell Carcinoma via Activating MMP1/PI3K/Akt Signaling Pathway. Cancers 34 35205603
2020 Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway. Environmental toxicology 33 33226171
2017 An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13. BioTechniques 33 29048269
2009 NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. Journal of cellular physiology 33 19591174
2016 Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol. Journal of periodontal & implant science 32 27127689
2015 Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation. Translational oncology 32 25926075
2011 Absence of MMP2 expression correlates with poor clinical outcomes in rectal cancer, and is distinct from MMP1-related outcomes in colon cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 31 21531813
2018 Tryptophan photo-product FICZ upregulates AHR/MEK/ERK-mediated MMP1 expression: Implications in anti-fibrotic phototherapy. Journal of dermatological science 30 29703420
2004 Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. Biological chemistry 30 14977049
2015 Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast. Molecular and cellular biochemistry 29 26298287
2022 MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma. Computational and mathematical methods in medicine 28 36105241
2010 A functional polymorphism in MMP1 could influence osteomyelitis development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 19821768
2022 Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer. Cancers 27 35267540
2016 Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis. Scientific reports 27 27324842
2012 The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse. International urogynecology journal 27 23108733
2022 SOD3 Suppresses the Expression of MMP-1 and Increases the Integrity of Extracellular Matrix in Fibroblasts. Antioxidants (Basel, Switzerland) 26 35624792
2019 Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma. Journal of cutaneous pathology 25 31677173
2016 Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts. PloS one 25 26829555
2016 DDR2-CYR61-MMP1 Signaling Pathway Promotes Bone Erosion in Rheumatoid Arthritis Through Regulating Migration and Invasion of Fibroblast-Like Synoviocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 25 27653023
2013 Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes. The Journal of investigative dermatology 25 24352036
2012 Expression of STAT3, MMP-1 and TIMP-1 in gastric cancer and correlation with pathological features. Molecular medicine reports 25 22469989
2023 Wogonin Restrains the Malignant Progression of Lung Cancer Through Modulating MMP1 and PI3K/AKT Signaling Pathway. Protein and peptide letters 24 36305146
2022 Molecular Patho-mechanisms of cervical cancer (MMP1). Annals of medicine and surgery (2012) 24 35444805
2021 Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo. European journal of pharmacology 24 34062170
2018 The Effect of Pulsed Electric Field on Expression of ECM proteins: Collagen, Elastin, and MMP1 in Human Dermal Fibroblasts. Journal of electroanalytical chemistry (Lausanne, Switzerland) 23 29977178
2017 p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC. Molecular cancer research : MCR 23 28637905
2011 MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC genomics 22 21244711
1999 Direct action by doxycycline against canine osteosarcoma cell proliferation and collagenase (MMP-1) activity in vitro. In vivo (Athens, Greece) 22 10586373
2002 Influence of hepatic arterial blockage on blood perfusion and VEGF, MMP-1 expression of implanted liver cancer in rats. World journal of gastroenterology 21 12046073
2024 IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1. Cell death discovery 20 38320998
2019 Platelet-secreted CCL3 and its receptor CCR5 promote invasive and migratory abilities of anaplastic thyroid carcinoma cells via MMP-1. Cellular signalling 20 31344439
2010 Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Experimental dermatology 20 20201953
2014 MMP-1 promoter genotype and haplotype association with posterior tibial tendinopathy. Gene 19 24995609
2004 Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression. Biochemical and biophysical research communications 19 15240110
2018 Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease markers 18 29670668
2015 Activity of MMP1 and MMP13 and amino acid metabolism in patients with alcoholic liver cirrhosis. Medical science monitor : international medical journal of experimental and clinical research 18 25863779
2011 Correlation between MMP1-PAR1 axis and clinical outcome of primary gallbladder carcinoma. Japanese journal of clinical oncology 18 21835828
1997 cAMP involvement in the expression of MMP-2 and MT-MMP1 metalloproteinases in human endothelial cells. Arteriosclerosis, thrombosis, and vascular biology 18 9409309
2019 Results of successive EORTC-CLG 58 881 and 58 951 trials in paediatric T-cell acute lymphoblastic leukaemia (ALL). British journal of haematology 17 31124581
2019 IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1. Digestive diseases and sciences 17 31350707
2018 Leptin induces MMP1/13 and ADAMTS 4 expressions through bone morphogenetic protein-2 autocrine effect in human chondrocytes. Journal of cellular biochemistry 17 29236309
2015 miR-526b targets 3' UTR of MMP1 mRNA. Experimental & molecular medicine 17 26292968
2015 Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro. Genetics and molecular research : GMR 17 26505388
2014 A dual tyrosine kinase inhibitor lapatinib suppresses overexpression of matrix metallopeptidase 1 (MMP1) in endometrial cancer. Journal of molecular medicine (Berlin, Germany) 17 24820961
2007 Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression. Journal of cosmetic science 17 17342265
2009 RhoB enhances migration and MMP1 expression of prostate cancer DU145. Experimental and molecular pathology 16 19782069
2006 Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Anticancer research 16 17094476
2022 RUNX2 facilitates aggressiveness and chemoresistance of triple negative breast cancer cells via activating MMP1. Frontiers in oncology 15 36483054
2001 The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. European journal of biochemistry 15 11248710
2023 N-acetyltransferase 10 promotes the progression of oral squamous cell carcinoma through N4-acetylcytidine RNA acetylation of MMP1 mRNA. Cancer science 14 37705232
2020 Transcription factor EGR-1 transactivates the MMP1 gene promoter in response to TNFα in HaCaT keratinocytes. BMB reports 14 32317080
2015 Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. A meta-analysis. Zeitschrift fur Rheumatologie 14 25854159
2009 Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horses. BMC physiology 14 19552796
2022 ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer. Acta biochimica et biophysica Sinica 13 36789689
2021 PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma. Frontiers in oncology 13 33816223
2022 The miR-145-MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance. Pharmacological research 12 35358680
2022 Expression of Polyamine Oxidase in Fibroblasts Induces MMP-1 and Decreases the Integrity of Extracellular Matrix. International journal of molecular sciences 12 36142401
2022 COL8A1 enhances the invasion/metastasis in MDA-MB-231 cells via the induction of IL1B and MMP1 expression. Biochemical and biophysical research communications 12 36577251
2020 UVA influenced the SIRT1-miR-27a-5p-SMAD2-MMP1/COL1/BCL2 axis in human skin primary fibroblasts. Journal of cellular and molecular medicine 12 32790210
2003 MMP-1 and MMP-2 expression in uterine leiomyosarcoma and correlation with different clinicopathologic parameters. Journal of the Society for Gynecologic Investigation 12 14519487
2012 Suture compression induced bone resorption with intensified MMP-1 and 13 expressions. Bone 11 22819631