Affinage

MMP1

Interstitial collagenase · UniProt P03956

Length
469 aa
Mass
54.0 kDa
Annotated
2026-06-10
100 papers in source corpus 36 papers cited in narrative 36 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP-1 is a secreted, zinc-dependent interstitial collagenase whose catalytic domain in solution retains the fold seen in crystal structures, requiring only local rearrangements rather than major domain motions (PMID:21945315), and which functions as a central effector of extracellular matrix remodeling, tumor invasion, and tissue homeostasis (PMID:19608765, PMID:29896303). Beyond cleaving structural matrix, MMP-1 acts proteolytically on defined substrates to generate paracrine signals: it releases membrane-bound EGF-like ligands (Amphiregulin, HB-EGF, TGFα) from tumor cells to suppress osteoblast osteoprotegerin via EGFR and potentiate osteolytic bone metastasis (PMID:19608765), and it cleaves laminin subunit alpha-5 to produce fragments that drive integrin αvβ3-dependent, VEGF-independent angiogenesis (PMID:27324842). A recurrent extracellular mechanism is MMP-1 activation of protease-activated receptor 1 (PAR1): on sensory neurons it triggers substance P release and NK1R-driven perineural invasion in pancreatic cancer (PMID:29896303), on fibroblasts it induces oxidative-stress-dependent premature senescence that fuels tumor growth (PMID:33684534), and on colon cancer cells it activates MAPK/ERK signaling to engage an ETV4-dependent positive feedback loop (PMID:34753916). MMP1 transcription integrates numerous upstream inputs converging largely on the MAPK/AP-1 module: UV, cytokine, growth factor, integrin, and aryl hydrocarbon receptor signals activate ERK and JNK to drive c-Fos/c-Jun AP-1 activity (PMID:15930517, PMID:29703420, PMID:27653023, PMID:21440529), and these cascades are restrained by Cdc42-mediated ERK repression (PMID:15728253, PMID:24352036) and by PPARδ/MKP-7 suppression of JNK (PMID:23639976). Direct transcriptional activators binding the MMP1 promoter include ETS-family factors ETV4 and ETS1 downstream of the CIC tumor suppressor (PMID:29251790, PMID:31670855), STAT3 acting downstream of IL-6/IL-8 (PMID:25926075, PMID:38320998), EGR-1 (PMID:32317080), Slug (PMID:28334049), and RUNX2 (PMID:36483054), while DNA methylation of the promoter suppresses transcription and promoter hypomethylation drives overexpression and tamoxifen resistance (PMID:18178580, PMID:35267540). MMP1 mRNA itself is stabilized by NAT10-mediated ac4C acetylation (PMID:37705232) and can be propagated between cells as extracellular-vesicle cargo to remodel the metastatic niche (PMID:28262727, PMID:35254603).

Mechanistic history

Synthesis pass · year-by-year structured walk · 28 steps
  1. 2001 High

    Established an upstream cell-surface inducer of MMP-1, showing that homophilic CD147 (EMMPRIN) interactions stimulate MMP-1 production in a glycosylation-dependent manner.

    Evidence Purified native vs. deglycosylated CD147, blocking antibody, CD147-Fc fusion, MMP-1 ELISA in dermal fibroblasts

    PMID:11280798

    Open questions at the time
    • Does not define the intracellular signaling pathway linking CD147 engagement to MMP1 transcription
    • Receptor for CD147 on fibroblasts not identified
  2. 2005 Medium

    Defined the core MAPK/AP-1 transcriptional circuit by which UV induces MMP-1, mapping induction to ERK/c-Fos and JNK/c-Jun arms.

    Evidence MEK1 and SEK1 inhibitors, AP-1 EMSA, MMP-1 ELISA in human dermal fibroblasts

    PMID:15930517

    Open questions at the time
    • Pharmacological inhibitor specificity not genetically confirmed
    • Does not identify the direct AP-1 promoter contacts
  3. 2005 High

    Identified Rho GTPase control over MMP-1, showing Cdc42 represses MMP-1 by suppressing ERK1/2 while Rac1 is required for the effect.

    Evidence siRNA knockdown of Cdc42/RhoA/Rac1 with siRNA-resistant rescue, kinase inhibitors, ELISA in skin fibroblasts

    PMID:15728253

    Open questions at the time
    • Mechanism by which Cdc42 represses ERK1/2 not resolved
    • Upstream activators of Cdc42 in this context not defined
  4. 2006 High

    Placed mmp1 downstream of polarity loss in an in vivo invasion model, showing scribble-loss/JNK signaling drives Fos-dependent mmp1 transcription to enable invasiveness.

    Evidence Drosophila genetic epistasis, Mmp1 RNAi, Timp overexpression, in vivo imaginal disc invasion assays

    PMID:17082773

    Open questions at the time
    • Drosophila Mmp1 substrate(s) mediating invasion not specified here
    • Conservation of the scribble-JNK-Fos-mmp1 axis in mammalian MMP1 not tested
  5. 2008 High

    Demonstrated epigenetic control of MMP1, showing promoter DNA methylation at -1538 and a methylated promoter SNP suppress transcription via altered nuclear-protein binding.

    Evidence 5-aza-2'-deoxycytidine, bisulfite sequencing, promoter luciferase, ChIP, EMSA in amnion fibroblasts

    PMID:18178580

    Open questions at the time
    • Identity of the methylation-sensitive nuclear protein not determined
    • Methyltransferase responsible not identified
  6. 2008 High

    Established a tissue-level paracrine route to MMP-1 induction, showing UV DNA damage in keratinocytes generates soluble mediators that drive dermal fibroblast MMP-1.

    Evidence DNA repair enzyme liposomes, conditioned-medium transfer from irradiated keratinocytes, MMP-1 mRNA/protein in human skin

    PMID:18459971

    Open questions at the time
    • The soluble mediator(s) transmitting the signal not identified
    • Receptor on fibroblasts not defined
  7. 2008 High

    Revealed a transcriptional brake on MMP1, showing Met-phosphorylated MUC1 cooperates with p53 to suppress AP-1 activity at the MMP1 promoter and limit invasion.

    Evidence Co-IP, confocal nuclear imaging, MMP1 promoter luciferase, invasion assay in pancreatic cancer cells

    PMID:18625714

    Open questions at the time
    • Direct binding of the MUC1-p53 complex to the promoter not shown
    • Quantitative contribution relative to other AP-1 inputs unclear
  8. 2009 High

    Defined a mechanistic substrate-based metastasis pathway, showing MMP1 sheds EGF-like ligands to suppress osteoblast OPG via EGFR and potentiate osteolytic bone metastasis.

    Evidence In vitro cleavage assays, EGFR inhibition, osteoblast co-culture/osteoclastogenesis, in vivo bone metastasis model

    PMID:19608765

    Open questions at the time
    • Precise cleavage sites on Amphiregulin/HB-EGF/TGFα not mapped
    • Relative contributions of the three ligands not dissected
  9. 2010 Medium

    Connected hypoxia and Akt signaling to MMP1, identifying HIF-1α/CXCR4/ERK and Akt-CCN2-ERK/Ets1 routes converging on MMP1 induction.

    Evidence HIF-1α/CXCR4/Akt/CCN2 siRNA, AMD3100, ERK inhibitors in chondrosarcoma and dermal fibroblasts

    PMID:20102637 PMID:20201953

    Open questions at the time
    • Direct promoter elements engaged downstream not mapped
    • Cell-type generality across the two systems not established
  10. 2011 Medium

    Provided a solution-state structural baseline, showing the MMP-1 catalytic domain retains its crystallographic fold with only local rearrangements.

    Evidence Paramagnetic NMR (pseudocontact shifts, RDCs) with lanthanide tags on the catalytic domain

    PMID:21945315

    Open questions at the time
    • No mutagenesis validation of inferred rearrangements
    • Full-length enzyme including hemopexin domain not analyzed
  11. 2011 Medium

    Linked MMP1 promoter polymorphism to bimodal endothelial expression and identified ETS1/ETS2/GATA3 as promoter-binding factors at that region.

    Evidence Microarray, RT-PCR, MMP1 activity assay, sequencing, ChIP in HUVECs from many donors

    PMID:21244711

    Open questions at the time
    • Functional consequence of each transcription factor on expression not isolated
    • Allele-specific binding not directly demonstrated
  12. 2013 Medium

    Showed integrin-collagen context-specific MMP-1 induction, with α2β1/collagen-I driving ERK-dependent MMP-1 in keratinocytes under Cdc42 negative control.

    Evidence ERK/p38/JNK inhibitors, Rho GTPase activity assays, MMP-1 western/ELISA in primary keratinocytes on collagen I

    PMID:24352036

    Open questions at the time
    • Whether the same circuit operates in fibroblasts not tested here
    • Direct integrin-to-ERK coupling mechanism not defined
  13. 2013 Medium

    Identified a JNK-restraining mechanism, showing PPARδ stabilizes MKP-7 mRNA to suppress JNK and reduce UVB-induced MMP-1.

    Evidence GW501516, PPARδ siRNA, MAPK inhibitors, mRNA stability assay, in vivo hairless mouse UVB model

    PMID:23639976

    Open questions at the time
    • Mechanism of PPARδ-driven MKP-7 mRNA stabilization not defined
    • Contribution of MKP-7 to ERK-driven MMP-1 not addressed
  14. 2014 High

    Distinguished MMP substrate preferences in vivo, showing Mmp1 preferentially cleaves DE-cadherin junctions while Mmp2 degrades basement membrane during tissue dissociation.

    Evidence Fat body-specific RNAi screen, genetic interaction, biochemical assays, immunostaining in Drosophila

    PMID:25520167

    Open questions at the time
    • Direct cadherin cleavage by mammalian MMP1 not demonstrated
    • Structural basis of substrate selectivity not addressed
  15. 2016 Medium

    Defined a pro-angiogenic substrate axis, showing MMP1 cleaves LAMA5 to generate fragments that drive integrin αvβ3-dependent, VEGF-independent angiogenesis.

    Evidence MMP1 siRNA, secretome proteomics, endothelial angiogenesis assay, αvβ3 blockade, xenograft

    PMID:27324842

    Open questions at the time
    • LAMA5 cleavage sites and active fragment sequence not fully defined
    • Direct fragment-integrin binding not biochemically resolved
  16. 2016 Medium

    Implicated aryl hydrocarbon receptor signaling in MMP-1 control, showing kynurenine drives AHR-dependent MMP-1 upregulation and collagen downregulation.

    Evidence AHR agonist/antagonist, CYP1A-1 reporter, western/qRT-PCR, in vivo rat dermal fibrosis model

    PMID:26992058

    Open questions at the time
    • Whether AHR acts directly on the MMP1 promoter not shown
    • Downstream kinase coupling not defined here
  17. 2017 Medium

    Identified Slug as a direct MMP1 transcriptional activator linked to drug resistance, binding three promoter sites.

    Evidence Luciferase reporter, ChIP-qPCR for Slug binding, western, drug sensitivity assays in breast cancer cells

    PMID:28334049

    Open questions at the time
    • Functional ranking of the three binding sites not resolved
    • In vivo relevance of Slug-MMP1 axis not tested
  18. 2017 Medium

    Established MMP1 as transferable extracellular-vesicle cargo, showing EV-borne MMP1 mRNA induces mesothelial apoptosis to breach the peritoneal barrier.

    Evidence EV isolation/transcriptomics, apoptosis assays in vitro/in vivo, patient ascites EVs in ovarian cancer

    PMID:28262727

    Open questions at the time
    • Whether translated MMP1 protein or RNA itself drives apoptosis not separated
    • Receptor/effector in mesothelial apoptosis not defined
  19. 2018 High

    Defined an MMP1-PAR1 neuronal paracrine loop driving perineural invasion via substance P/NK1R/ERK signaling.

    Evidence DRG/Matrigel PNI system, sciatic nerve model, MMP1 shRNA, PAR1/NK1R antagonists in pancreatic cancer

    PMID:29896303

    Open questions at the time
    • Whether MMP1 cleaves PAR1 directly at the tethered ligand not shown
    • Contribution of neuronal vs. tumor-derived MMP1 not separated
  20. 2018 High

    Built the CIC-ETV4-MMP1 tumor-suppressor axis, showing CIC loss elevates ETV4 to induce MMP1 and that MMP1 is essential for the resulting phenotypes.

    Evidence CIC/ETV4/MMP1 gain- and loss-of-function epistasis, invasion/proliferation assays, xenograft in HCC

    PMID:29251790

    Open questions at the time
    • Direct ETV4 binding to MMP1 promoter not shown in this study
    • Downstream MMP1 substrate mediating proliferation not identified
  21. 2018 Medium

    Extended MAPK-coupled induction to additional inputs, implicating AHR/MEK-ERK, GSDMC/ERK-JNK, DDR2-CYR61-AP-1/ETS1, and PKD3 in MMP1 transcription.

    Evidence AHR/GSDMC/PKD3 knockdowns, CYR61 shRNA, AP-1 ChIP, MAPK inhibitors across fibroblasts, keratinocytes, synoviocytes, chondrocytes

    PMID:27653023 PMID:29428815 PMID:29652915 PMID:29703420

    Open questions at the time
    • Hierarchy among these parallel inputs at the promoter not integrated
    • Most rely on pharmacological inhibitors without genetic confirmation
  22. 2019 Medium

    Confirmed ETV4 as a direct MMP1 activator in lung cancer with MMP1 required for ETV4-driven proliferation and migration.

    Evidence Luciferase reporter, ETV4 gain/loss-of-function, MMP1 inhibition, in vitro/in vivo metastasis assays in NSCLC

    PMID:31670855

    Open questions at the time
    • Precise ETV4 binding motif not mapped
    • Interaction with other ETS factors at the promoter not addressed
  23. 2020 Medium

    Identified EGR-1 as a direct TNFα-responsive MMP1 transactivator acting downstream of all three MAPKs.

    Evidence Promoter deletion/EBS mutation, luciferase, EGR-1 overexpression/siRNA in HaCaT keratinocytes

    PMID:32317080

    Open questions at the time
    • No ChIP confirmation of endogenous EGR-1 occupancy
    • Interplay between EGR-1 and AP-1 at the promoter not resolved
  24. 2021 Medium

    Generalized MMP1-PAR1 signaling to tumor microenvironment cross-talk, establishing a TAM-derived MMP1/PAR1/ERK/ETV4/MMP1 feedback loop and MMP1/TGF-β1-induced fibroblast senescence driving tumor growth.

    Evidence Exogenous MMP1, PAR1/ERK inhibitors, ETV4 ChIP, co-culture senescence/oxidative-stress assays, in vivo models in colon and lung cancer

    PMID:33684534 PMID:34753916

    Open questions at the time
    • Whether MMP1 directly cleaves and activates PAR1 not biochemically shown
    • Source-cell heterogeneity (TAM vs. tumor vs. fibroblast) not fully partitioned
  25. 2022 Medium

    Added RUNX2 as a direct MMP1 activator and linked MMP1 promoter hypomethylation to tamoxifen resistance reversible by MMP1 knockdown.

    Evidence RUNX2 ChIP, methylation microarray/bisulfite sequencing, shRNA knockdown, functional assays and xenografts in breast cancer

    PMID:35267540 PMID:36483054

    Open questions at the time
    • Mechanism linking hypomethylation to drug resistance downstream of MMP1 not defined
    • Relationship between RUNX2 binding and methylation state not integrated
  26. 2022 Medium

    Extended exosomal MMP-1 propagation to breast cancer, showing exosomal MMP-1 engages recipient-cell PAR1 to initiate EMT and amplify MMP-1 secretion.

    Evidence Exosome isolation/MS, PAR1 link, Transwell assays, lung colonization model, patient sera in TNBC

    PMID:35254603

    Open questions at the time
    • Whether exosomal MMP-1 is catalytically active on PAR1 not directly shown
    • Quantitative threshold for recipient EMT not defined
  27. 2023 Medium

    Established post-transcriptional control of MMP1, showing NAT10-mediated ac4C acetylation stabilizes MMP1 mRNA to support malignancy.

    Evidence NAT10 knockdown, ac4C-RIP, mRNA stability assay, MMP1 rescue, xenograft in oral squamous cell carcinoma

    PMID:37705232

    Open questions at the time
    • Specific ac4C-modified sites on MMP1 mRNA not mapped
    • Whether acetylation also affects translation not addressed
  28. 2024 Medium

    Defined an IL-8/STAT3 stromal route, showing fibroblast STAT3 activation upregulates MMP1 that supports cancer-cell invasion through ECM degradation.

    Evidence IL-8 stimulation, STAT3 inhibitor TPCA-1, co-culture Transwell invasion in HNSCC

    PMID:38320998

    Open questions at the time
    • Direct STAT3 binding to MMP1 promoter in fibroblasts not shown here
    • ECM substrate cleaved by fibroblast MMP1 not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the many parallel transcriptional, epigenetic, and post-transcriptional inputs are quantitatively integrated at the MMP1 locus in a given cell type, and whether MMP1 directly proteolyzes PAR1 to drive its many paracrine effects, remain unresolved.
  • No unified model ranking AP-1, STAT3, ETS, RUNX2, EGR-1, Slug, and methylation inputs
  • Direct enzymatic cleavage of PAR1 by MMP1 not biochemically established in the corpus
  • Full-length enzyme structure and substrate-selectivity determinants not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3 GO:0140096 catalytic activity, acting on a protein 3
Localization
GO:0005576 extracellular region 3 GO:0031012 extracellular matrix 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-74160 Gene expression (Transcription) 6 R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-1474244 Extracellular matrix organization 2
Partners
EGFREGR1ETS1ETV4LAMA5PAR1RUNX2STAT3

Evidence

Reading pass · 36 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 CD147 (EMMPRIN) stimulates MMP-1 production via homophilic CD147-CD147 interactions, predominantly through the first immunoglobulin domain; deglycosylated CD147 failed to induce MMP-1 and instead antagonized native CD147-induced MMP-1, demonstrating that glycosylation is required for the MMP-1-inducing activity. Purified native vs. deglycosylated CD147, anti-CD147 antibody inhibition, recombinant CD147-Fc fusion protein, MMP-1 ELISA in dermal fibroblasts Cancer research High 11280798
2006 In Drosophila, loss of the polarity gene scribble activates JNK signaling, which promotes Fos-dependent transcriptional activation of mmp1, leading to tumor cell invasiveness; Timp expression or Mmp1 RNAi knockdown suppressed cell invasiveness downstream of JNK. Genetic epistasis (scribble mutant clones + Ras activation), RNAi knockdown of Mmp1, Timp overexpression, in vivo invasion assays in Drosophila imaginal discs The EMBO journal High 17082773
2009 MMP1 proteolytically releases membrane-bound EGF-like ligands (Amphiregulin, HB-EGF, TGFα) from breast cancer tumor cells, which then suppress osteoprotegerin (OPG) expression in osteoblasts via EGFR signaling, thereby potentiating osteoclast differentiation and osteolytic bone metastasis. In vitro protease cleavage assays, EGFR inhibitor treatment, osteoblast co-culture, osteoclastogenesis assays, in vivo bone metastasis model Genes & development High 19608765
2008 UV-induced DNA damage in epidermal keratinocytes initiates release of soluble mediators that signal dermal fibroblasts to produce MMP-1; photolyase-mediated DNA repair of epidermal UV damage reduced MMP-1 mRNA and protein in both epidermal and dermal compartments, and conditioned medium from irradiated keratinocytes enhanced MMP-1 in unirradiated fibroblasts. Liposome-encapsulated DNA repair enzymes (T4 endonuclease V, UV endonuclease), conditioned medium transfer from irradiated keratinocytes to unirradiated fibroblasts, MMP-1 mRNA and protein measurement in human skin Experimental dermatology High 18459971
2008 Met receptor tyrosine kinase phosphorylates MUC1 cytoplasmic tail at YHPM; phosphorylated MUC1CT enhances its interaction with p53, which suppresses AP1 transcription factor activity at the MMP1 promoter, reducing MMP1 transcription and HGF-induced invasiveness. Co-IP, real-time confocal imaging of nuclear localization, luciferase promoter assay, western blot, invasion assay in pancreatic cancer cells The Journal of biological chemistry High 18625714
2005 UV radiation increases MMP-1 expression in human dermal fibroblasts via ERK (MEK1) and JNK (SEK1) signaling pathways leading to increased c-Fos expression and c-Jun phosphorylation/expression, and consequent AP-1 DNA binding activity; EPA inhibited this induction by blocking MEK1/ERK/c-Fos and SEK1/JNK/c-Jun pathways. Kinase inhibitors (MEK1 inhibitor, SEK1 inhibitor), western blot for pathway activation, AP-1 EMSA, MMP-1 ELISA in human dermal fibroblasts Journal of lipid research Medium 15930517
2005 Cdc42 downregulates MMP-1 expression in human skin fibroblasts via repression of the ERK1/2 pathway; silencing Cdc42 by siRNA induced a 15-fold increase in MMP-1 secretion dependent on ERK1/2, while the p38 MAP kinase pathway played an inhibitory role; Rac1 silencing reduced the effect of Cdc42 suppression. siRNA knockdown of Rho GTPases (Cdc42, RhoA, Rac1), chemical kinase inhibitors, rescue by Cdc42 re-expression with siRNA-resistant construct, ELISA, RT-PCR in human skin fibroblasts Journal of cell science High 15728253
2008 DNA methylation at position -1538 in the MMP1 promoter suppresses MMP1 transcription in amnion fibroblasts; inhibition of DNA methylation with 5-aza-2'-deoxycytidine significantly increased MMP1 gene transcription; a novel T>C SNP in the MMP1 promoter that is always methylated in vivo had reduced promoter activity, and methylation at this site increased affinity for a nuclear protein. 5-aza-2'-deoxycytidine treatment, bisulfite sequencing, plasmid transfection promoter activity assay, chromatin immunoprecipitation (ChIP), electrophoretic mobility shift (nuclear protein binding) in amnion fibroblasts Human molecular genetics High 18178580
2011 MMP1 bimodal expression in endothelial cells is linked to a promoter polymorphism; ChIP experiments showed that transcription factors ETS1, ETS2 and GATA3 bind to the MMP1 promoter in the region of this polymorphism and may contribute to bimodal expression. Microarray analysis, hierarchical clustering, RT-PCR, MMP1 activity assay, DNA sequencing, chromatin immunoprecipitation (ChIP) in HUVECs from 15–69 individuals BMC genomics Medium 21244711
2011 The catalytic domain of MMP-1 in solution retains the overall fold seen in crystal structures, requiring only local rearrangements (not major domain rearrangements) to reconcile X-ray and NMR data, as assessed by paramagnetic NMR using lanthanide binding tags. NMR pseudocontact shifts and paramagnetic residual dipolar couplings using lanthanide binding tags on the MMP-1 catalytic domain FEBS letters Medium 21945315
2013 In collagen-activated human keratinocytes, MMP-1 expression is induced via α2β1 integrin contact with fibrillar type I collagen through ERK activation; Cdc42 negatively regulates this process by suppressing ERK activity; p38 or JNK inhibition had no effect on MMP-1 production in this context. ERK, p38, and JNK inhibitors; Rho GTPase activity assays; MMP-1 western blot and ELISA in primary human keratinocytes on type I collagen The Journal of investigative dermatology Medium 24352036
2013 PPARδ activation suppresses UVB-induced MMP-1 secretion in human dermal fibroblasts through MKP-7-mediated suppression of JNK signaling; PPARδ-mediated mRNA stabilization of MKP-7 was responsible for inhibition of JNK and consequent MMP-1 reduction. PPARδ-specific ligand GW501516, PPARδ siRNA knockdown, JNK/p38/ERK inhibitors, mRNA stability assay, in vivo HR-1 hairless mouse model with UVB exposure The Journal of investigative dermatology Medium 23639976
2014 In Drosophila metamorphosis, Mmp1 preferentially cleaves DE-cadherin-mediated cell-cell junctions to induce fat body cell dissociation, while Mmp2 preferentially degrades basement membrane components; Mmp1 and Mmp2 act cooperatively to achieve complete fat body tissue dissociation. Fat body-specific RNAi screen, genetic interaction experiments, cellular and biochemical assays, immunostaining in Drosophila Scientific reports High 25520167
2016 MMP1 cleaves laminin subunit alpha-5 (LAMA5), generating proteolytic fragments in the secretome of oncogenic H-Ras-transformed epithelial cells; these LAMA5 fragments promote endothelial cell angiogenesis via integrin αvβ3, representing a VEGF-independent pro-angiogenic mechanism. MMP1 knockdown (siRNA), secretome proteomics, endothelial cell angiogenesis assay, antibody-based integrin αvβ3 inhibition, in vivo xenograft model Scientific reports Medium 27324842
2018 MMP1 activates protease-activated receptor 1 (PAR1) on dorsal root ganglion neurons, inducing substance P (SP) release, which then activates NK1R on pancreatic ductal adenocarcinoma cells to enhance migration, invasion, and perineural invasion via SP/NK1R/ERK signaling; MMP1 silencing or PAR1/NK1R antagonism inhibited this paracrine loop. Matrigel/DRG in vitro PNI system, murine sciatic nerve invasion model, shRNA silencing of MMP1, PAR1 and NK1R antagonists, AKT activation assays, MRI monitoring Theranostics High 29896303
2018 CIC (Capicua) represses ETV4 transcription; loss of CIC in hepatocellular carcinoma cells elevates ETV4, which in turn induces MMP1 expression; MMP1 knockdown completely blocked CIC-deficiency-induced HCC cell proliferation and invasion, establishing the CIC-ETV4-MMP1 axis. CIC overexpression/knockdown, ETV4 overexpression/knockdown, MMP1 knockdown, in vitro proliferation and invasion assays, in vivo xenograft model Hepatology (Baltimore, Md.) High 29251790
2018 The AHR ligand FICZ upregulates MMP1 expression in human dermal fibroblasts via AHR-dependent activation of MEK/ERK signaling; AHR knockdown abolished FICZ-induced MMP1 upregulation, and MEK/ERK inhibitors blocked FICZ-induced MMP1 induction. AHR knockdown (siRNA), selective MEK/ERK inhibitors, qRT-PCR, ELISA, western blot in NHDFs Journal of dermatological science Medium 29703420
2018 Collagen II activates DDR2 phosphorylation in rheumatoid arthritis fibroblast-like synoviocytes, which induces CYR61 through AP-1 transcription factor activation; CYR61 then accelerates MMP1 production via ETS1, promoting FLS invasion and bone erosion. Co-stimulation with collagen II, adenoviral shRNA (Ad-shCYR61), luciferase reporter assays, AP-1 ChIP, ETS1 overexpression, in vivo collagen-induced arthritis rat model with micro-CT Journal of bone and mineral research High 27653023
2018 Gasdermin C (GSDMC) is induced by UV irradiation in human skin keratinocytes and contributes to UV-induced MMP-1 expression through activation of ERK and JNK pathways; GSDMC knockdown reduced UV-induced MMP-1, while GSDMC overexpression increased MMP-1 expression and ERK/JNK activities. GSDMC knockdown and overexpression, ERK and JNK inhibitors, qRT-PCR and western blot in primary keratinocytes and HaCaT cells Journal of dermatological science Medium 29428815
2010 Akt inhibition in human dermal fibroblasts upregulates MMP1 through a CCN2-dependent pathway; Akt blockade elevated CCN2, which activated ERK1/2 and Ets1 phosphorylation; ERK1/2 inhibitor completely abrogated CCN2-induced MMP1, while CCN2 siRNA partially suppressed Akt-inhibition-induced MMP1. Akt-specific pharmacological inhibitor and Akt siRNA, CCN2 siRNA, ERK1/2 inhibitor UO126, western blot, RT-PCR in human dermal fibroblasts Experimental dermatology Medium 20201953
2010 Hypoxia-induced HIF-1α upregulates CXCR4 in chondrosarcoma cells, which through SDF1 signaling and ERK activation increases MMP1 expression and cell invasion; siRNA against HIF-1α or CXCR4, AMD3100 (CXCR4 inhibitor), or ERK inhibitor U0126 inhibited both MMP1 expression and invasion. HIF-1α siRNA, CXCR4 siRNA, CXCR4 inhibitor AMD3100, ERK inhibitor U0126, in vitro invasion assay in chondrosarcoma JJ cells Molecular cancer Medium 20102637
2011 EGFR ligands (EGF, TGF-α) enhance MMP1 expression via ERK1/2 pathway activation in SK-BR3 breast cancer cells; MEK inhibitor U0126 blocked ERK1/2 activation and MMP1 induction; Akt pathway inhibition paradoxically augmented MMP1 expression through reciprocal activation of ERK1/2. EGFR ligand stimulation, MEK inhibitor U0126, PI3K inhibitor LY294002, tyrosine kinase inhibitors (erlotinib, lapatinib, canertinib), RT-PCR, western blot, ELISA, EMSA Biochemical and biophysical research communications Medium 21440529
2015 STAT3 activation enhances MMP-1 expression in lung adenocarcinoma cells; IL-6 stimulation of A549 cells increased MMP-1 mRNA and activated MMP-1 promoter transcription in a STAT3-dependent manner confirmed by STAT3 siRNA knockdown. IL-6 stimulation, STAT3 siRNA knockdown, MMP-1 promoter luciferase assay, RT-PCR in lung cancer cell lines; IHC co-localization in surgical biopsies Translational oncology Medium 25926075
2016 Kynurenine (Kyn) upregulates MMP-1 and downregulates type-I collagen in dermal fibroblasts via activation of aryl hydrocarbon receptor (AHR); a specific AHR antagonist inhibited Kyn-dependent modulation of CYP1A-1, MMP-1, and type-I collagen expression. AHR agonist (Kyn) treatment, AHR antagonist (6,2',4'-trimethoxyflavone), CYP1A-1 reporter assay, western blot, qRT-PCR in dermal fibroblasts; in vivo rat dermal fibrosis model Journal of cellular physiology Medium 26992058
2018 PKD3 (PRKD3), downstream of atypical PKCι, mediates IL-1/OSM-induced MMP1 expression in human chondrocytes; PKD3 silencing reduced STAT3 serine phosphorylation and all three MAPK groups, and decreased AP-1 gene expression (FOS, JUN), leading to reduced MMP1/13. Pan-PKD inhibitor, gene-specific siRNA (PKD isoforms), western blot for phospho-signaling, RT-PCR in human articular chondrocytes PloS one Medium 29652915
2017 MMP1 mRNA-carrying extracellular vesicles (EVs) from highly metastatic ovarian cancer cells are taken up by mesothelial cells, increasing MMP1 expression in mesothelial cells and inducing their apoptosis, thereby destroying the peritoneal mesothelium barrier to facilitate peritoneal dissemination. EV isolation and characterization, whole transcriptome analysis of EV cargo, in vitro and in vivo apoptosis assays, analysis of ascites-derived EVs from patients Nature communications Medium 28262727
2021 MMP1 derived from tumor-associated macrophages (TAMs) promotes colon cancer cell proliferation by activating PAR1, leading to MAPK/Erk signaling and altering c-Myc and ETV4; ETV4 then binds the MMP1 promoter to activate MMP1 transcription, establishing a positive MMP1/PAR1/Erk1/2/ETV4/MMP1 feedback loop. Exogenous MMP1 treatment, PAR1 inhibition, MAPK/Erk inhibitor, ChIP for ETV4 binding to MMP1 promoter, cell cycle analysis, in vitro and in vivo assays Cell death discovery Medium 34753916
2021 MMP1 expression by large cell carcinoma (LCC) cells is necessary and sufficient (in combination with TGF-β1) to induce premature senescence in pulmonary fibroblasts, which in turn drives LCC cell growth and invasion; PAR1 and oxidative stress are implicated in MMP1/TGF-β1-induced fibroblast senescence. MMP1 knockdown and overexpression, co-culture fibroblast senescence assay, PAR1 inhibition, oxidative stress measurements, in vivo mouse models Cancer letters Medium 33684534
2017 Slug directly binds to three putative binding sites in the MMP1 promoter and activates MMP1 transcription in breast cancer cells; enforced Slug expression in MCF-7 cells significantly upregulated MMP1, while Slug knockdown in MDR MCF-7/ADR cells reduced MMP1 expression. Dual luciferase reporter assay, ChIP-qPCR confirming Slug binding to MMP1 promoter sites, western blot, immunofluorescence, functional drug sensitivity assays PloS one Medium 28334049
2020 Transcription factor EGR-1 directly binds to an EBS (EGR-1 binding sequence) in the proximal MMP1 promoter and transactivates MMP1 in response to TNFα in HaCaT keratinocytes; EGR-1 siRNA silencing reduced TNFα-induced MMP-1 expression; all three MAPKs (ERK1/2, JNK, p38) mediate TNFα-induced MMP-1 via EGR-1 upregulation. MMP1 promoter deletion constructs, luciferase reporter assay, EGR-1 overexpression, EGR-1 siRNA knockdown, promoter EBS mutation, western blot in HaCaT keratinocytes BMB reports Medium 32317080
2022 RUNX2 directly binds to specific motifs in the MMP1 promoter and activates its transcription in triple negative breast cancer cells, promoting proliferation, migration, invasion and chemoresistance; RUNX2 silencing suppressed MMP1 expression and these malignant phenotypes. ChIP assay for RUNX2 binding to MMP1 promoter, qRT-PCR, RNA-sequencing, in vitro functional assays, in vivo xenograft tumorigenicity Frontiers in oncology Medium 36483054
2022 Exosomal MMP-1 from highly metastatic TNBC cells is taken up by less metastatic TNBC cells and interacts with membrane PAR1, initiating epithelial-mesenchymal transition (EMT) to enhance migration and invasion; recipient cells increase their own MMP-1 secretion after exosome uptake. Exosome isolation, mass spectrometry, western blot, Transwell invasion/migration assays, in vivo lung colonization model in nude mice, tissue microarray and patient serum analysis Breast cancer research and treatment Medium 35254603
2023 NAT10 promotes MMP1 mRNA stability via N4-acetylcytidine (ac4C) acetylation of MMP1 mRNA in oral squamous cell carcinoma; NAT10 knockdown reduced both total and ac4C-acetylated MMP1 mRNA levels and decreased MMP1 mRNA stability, impairing proliferation, migration, and invasion in an MMP1-dependent manner. NAT10 knockdown (lentivirus), ac4C-seq/RIP for acetylated MMP1 mRNA detection, mRNA stability assay, MMP1 rescue experiments, xenograft model Cancer science Medium 37705232
2022 MMP1 upregulation through promoter hypomethylation enhances tamoxifen resistance in breast cancer; MMP1 was hypomethylated and overexpressed in tamoxifen-resistant MCF-7 cells; shRNA-mediated MMP1 knockdown restored tamoxifen sensitivity and increased apoptosis in vitro and in xenograft models. Methylation microarray, bisulfite sequencing, shRNA knockdown of MMP1, colony formation assay, flow cytometry, xenograft mouse model Cancers Medium 35267540
2024 IL-8 activates STAT3 signaling in fibroblasts to upregulate MMP1 expression; fibroblast-derived MMP1 then supports invasion of HNSCC cancer cells via extracellular matrix degradation; STAT3 phosphorylation inhibitor (TPCA-1) impaired the enhanced invasion triggered by fibroblasts. IL-8 stimulation of fibroblasts, STAT3 inhibitor TPCA-1, MMP1 measurement, Transwell invasion assay with co-culture system Cell death discovery Medium 38320998
2019 ETV4 directly upregulates MMP1 transcription in non-small cell lung cancer; luciferase reporter and gain/loss-of-function assays demonstrated the direct regulatory effect of ETV4 on MMP1 expression; MMP1 inhibition partially abolished ETV4-driven cell proliferation and migration. Microarray analysis, luciferase reporter assay, ETV4 gain- and loss-of-function, MMP1 inhibition, in vivo and in vitro metastasis assays Molecular carcinogenesis Medium 31670855

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS medicine 475 18447576
2001 Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer research 369 11280798
2006 JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. The EMBO journal 335 17082773
2017 Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. Nature communications 260 28262727
2009 ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes & development 248 19608765
2005 MMP-1: the elder of the family. The international journal of biochemistry & cell biology 217 15474975
2008 UV-induced DNA damage initiates release of MMP-1 in human skin. Experimental dermatology 147 18459971
2021 Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR. Theranostics 146 33391541
2015 High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis. Genetics and molecular research : GMR 135 26600542
2008 Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 108 18483334
2016 MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma. Cancer letters 97 27130665
2004 Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China. Carcinogenesis 96 15528217
2006 Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2, MMP-1, and MMP-9 expression. Molecular therapy : the journal of the American Society of Gene Therapy 84 16455304
2000 Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. Investigative ophthalmology & visual science 84 10670469
2018 MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells. Theranostics 83 29896303
2008 Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. The Journal of biological chemistry 79 18625714
2005 Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts. Journal of lipid research 79 15930517
2018 Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4-MMP1 axis. Hepatology (Baltimore, Md.) 76 29251790
2010 CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression. Molecular cancer 73 20102637
2003 Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 66 12873541
2014 Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles. Scientific reports 62 25520167
2009 MMP-1 polymorphism and its relationship to pathological processes. Journal of biosciences 60 19550047
2008 Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes. Human molecular genetics 60 18178580
2008 Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. BMC cancer 60 18366705
2020 TCONS_00012883 promotes proliferation and metastasis via DDX3/YY1/MMP1/PI3K-AKT axis in colorectal cancer. Clinical and translational medicine 59 33135346
2019 ETV4 overexpression promotes progression of non-small cell lung cancer by upregulating PXN and MMP1 transcriptionally. Molecular carcinogenesis 59 31670855
2014 Expression and regulation of MMP1, MMP3, and MMP9 in the chicken ovary in response to gonadotropins, sex hormones, and TGFB1. Biology of reproduction 59 24451989
2006 Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC cancer 59 17125518
2005 Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway. Journal of cell science 57 15728253
2019 Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxidative medicine and cellular longevity 54 30800206
2017 MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer. PloS one 54 28334049
2021 MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. Cancer letters 52 33684534
2002 Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells. Matrix biology : journal of the International Society for Matrix Biology 50 12009332
2019 miR-134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo. FEBS letters 49 30977909
2013 G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. The Journal of pathology 49 23338946
2022 Injectable MMP1-sensitive microspheres with spatiotemporally controlled exosome release promote neovascularized bone healing. Acta biomaterialia 48 36481504
2022 Exosomal MMP-1 transfers metastasis potential in triple-negative breast cancer through PAR1-mediated EMT. Breast cancer research and treatment 44 35254603
2018 Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways. Journal of dermatological science 44 29428815
2011 ERK/MAPK pathways play critical roles in EGFR ligands-induced MMP1 expression. Biochemical and biophysical research communications 44 21440529
2005 TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 43 16459052
2022 CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling. International journal of molecular sciences 42 35163100
2017 Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. PloS one 42 28961241
2019 MicroRNA hsa-miR-623 directly suppresses MMP1 and attenuates IL-8-induced metastasis in pancreatic cancer. International journal of oncology 41 31115512
2021 Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role. Cell death discovery 39 34753916
2018 RHCG Suppresses Tumorigenicity and Metastasis in Esophageal Squamous Cell Carcinoma via Inhibiting NF-κB Signaling and MMP1 Expression. Theranostics 37 29290801
2019 Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways. PloS one 36 31513610
2016 Kynurenine Modulates MMP-1 and Type-I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts. Journal of cellular physiology 36 26992058
2009 Association between MMP1 and MMP9 activities and ICAM1 cleavage induced by tumor necrosis factor in stromal cell cultures from eutopic endometria of women with endometriosis. Reproduction (Cambridge, England) 35 19661147
2022 HPRT1 Promotes Chemoresistance in Oral Squamous Cell Carcinoma via Activating MMP1/PI3K/Akt Signaling Pathway. Cancers 34 35205603
2011 The catalytic domain of MMP-1 studied through tagged lanthanides. FEBS letters 34 21945315
2015 Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation. Translational oncology 33 25926075
2011 Absence of MMP2 expression correlates with poor clinical outcomes in rectal cancer, and is distinct from MMP1-related outcomes in colon cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 31 21531813
2022 MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma. Computational and mathematical methods in medicine 30 36105241
2018 Tryptophan photo-product FICZ upregulates AHR/MEK/ERK-mediated MMP1 expression: Implications in anti-fibrotic phototherapy. Journal of dermatological science 30 29703420
2004 Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. Biological chemistry 30 14977049
2015 Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast. Molecular and cellular biochemistry 29 26298287
2016 Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis. Scientific reports 28 27324842
2013 PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling. The Journal of investigative dermatology 28 23639976
2010 A functional polymorphism in MMP1 could influence osteomyelitis development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 19821768
2022 Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer. Cancers 27 35267540
2022 Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis. International journal of molecular sciences 27 36076991
2018 Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PloS one 27 29652915
2002 Expression of MMP1 in surgical and radiation-impaired wound healing and its effects on the healing process. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 27 11934016
2022 SOD3 Suppresses the Expression of MMP-1 and Increases the Integrity of Extracellular Matrix in Fibroblasts. Antioxidants (Basel, Switzerland) 26 35624792
2021 Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo. European journal of pharmacology 26 34062170
2019 Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma. Journal of cutaneous pathology 26 31677173
2012 Expression of STAT3, MMP-1 and TIMP-1 in gastric cancer and correlation with pathological features. Molecular medicine reports 26 22469989
2023 Wogonin Restrains the Malignant Progression of Lung Cancer Through Modulating MMP1 and PI3K/AKT Signaling Pathway. Protein and peptide letters 25 36305146
2016 Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts. PloS one 25 26829555
2016 DDR2-CYR61-MMP1 Signaling Pathway Promotes Bone Erosion in Rheumatoid Arthritis Through Regulating Migration and Invasion of Fibroblast-Like Synoviocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 25 27653023
2013 Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes. The Journal of investigative dermatology 25 24352036
2022 Molecular Patho-mechanisms of cervical cancer (MMP1). Annals of medicine and surgery (2012) 24 35444805
2024 IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1. Cell death discovery 23 38320998
2009 Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. Molecular vision 23 20038976
2015 MMP1, 2, 3, 7, and 9 gene polymorphisms and urinary cancer risk: a meta-analysis. Genetic testing and molecular biomarkers 22 26301605
2011 MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC genomics 22 21244711
2018 The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk. Bioscience reports 21 30177524
2010 Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Experimental dermatology 20 20201953
2022 Identity of MMP1 and its effects on tumor progression in head and neck squamous cell carcinoma. Cancer medicine 18 35426219
2019 IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1. Digestive diseases and sciences 18 31350707
2018 Leptin induces MMP1/13 and ADAMTS 4 expressions through bone morphogenetic protein-2 autocrine effect in human chondrocytes. Journal of cellular biochemistry 18 29236309
2018 Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease markers 18 29670668
2015 Activity of MMP1 and MMP13 and amino acid metabolism in patients with alcoholic liver cirrhosis. Medical science monitor : international medical journal of experimental and clinical research 18 25863779
2011 Correlation between MMP1-PAR1 axis and clinical outcome of primary gallbladder carcinoma. Japanese journal of clinical oncology 18 21835828
1997 cAMP involvement in the expression of MMP-2 and MT-MMP1 metalloproteinases in human endothelial cells. Arteriosclerosis, thrombosis, and vascular biology 18 9409309
2025 Decoding the impact of MMP1+ malignant subsets on tumor-immune interactions: insights from single-cell and spatial transcriptomics. Cell death discovery 17 40394037
2010 MMP1 and MMP20 contribute to tooth agenesis in humans. Archives of oral biology 17 21144496
2009 RhoB enhances migration and MMP1 expression of prostate cancer DU145. Experimental and molecular pathology 16 19782069
2023 N-acetyltransferase 10 promotes the progression of oral squamous cell carcinoma through N4-acetylcytidine RNA acetylation of MMP1 mRNA. Cancer science 15 37705232
2022 RUNX2 facilitates aggressiveness and chemoresistance of triple negative breast cancer cells via activating MMP1. Frontiers in oncology 15 36483054
2008 Equine ANXA2 and MMP1 expression analyses in an experimental model of normal and pathological wound repair. Journal of dermatological science 15 18434095
2008 Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis. Journal of neuro-oncology 15 18604474
2022 Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma. Cancers 14 36010973
2021 PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma. Frontiers in oncology 14 33816223
2021 Acetylated Resveratrol and Oxyresveratrol Suppress UVB-Induced MMP-1 Expression in Human Dermal Fibroblasts. Antioxidants (Basel, Switzerland) 14 34439500
2020 Transcription factor EGR-1 transactivates the MMP1 gene promoter in response to TNFα in HaCaT keratinocytes. BMB reports 14 32317080
2020 MMP1 and MMP11 Expression in Peripheral Blood Mononuclear Cells upon Their Interaction with Breast Cancer Cells and Fibroblasts. International journal of molecular sciences 14 33396463
2015 Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. A meta-analysis. Zeitschrift fur Rheumatologie 14 25854159
2024 Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo. Scientific reports 13 39043893
2022 ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer. Acta biochimica et biophysica Sinica 13 36789689

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